File size: 16,410 Bytes
54487fc
 
 
 
 
 
1bdca6f
54487fc
 
 
 
1b49be5
54487fc
 
 
 
1bdca6f
 
1b49be5
 
54487fc
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
feb2bea
 
 
 
 
 
 
 
1b49be5
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
54487fc
 
 
 
 
 
 
 
1bdca6f
 
 
 
 
 
 
 
54487fc
 
 
1bdca6f
54487fc
 
 
1bdca6f
 
 
 
 
 
 
 
 
 
 
 
 
 
54487fc
 
 
1bdca6f
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
54487fc
 
 
 
1bdca6f
54487fc
 
 
 
 
 
 
1b49be5
 
54487fc
1bdca6f
54487fc
1bdca6f
 
 
 
54487fc
1bdca6f
54487fc
1bdca6f
 
 
 
54487fc
 
 
 
 
 
 
 
 
1b49be5
 
1bdca6f
 
 
54487fc
1bdca6f
 
 
 
54487fc
 
 
 
 
1bdca6f
 
 
54487fc
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
1
2
3
4
5
6
7
8
9
10
11
12
13
14
15
16
17
18
19
20
21
22
23
24
25
26
27
28
29
30
31
32
33
34
35
36
37
38
39
40
41
42
43
44
45
46
47
48
49
50
51
52
53
54
55
56
57
58
59
60
61
62
63
64
65
66
67
68
69
70
71
72
73
74
75
76
77
78
79
80
81
82
83
84
85
86
87
88
89
90
91
92
93
94
95
96
97
98
99
100
101
102
103
104
105
106
107
108
109
110
111
112
113
114
115
116
117
118
119
120
121
122
123
124
125
126
127
128
129
130
131
132
133
134
135
136
137
138
139
140
141
142
143
144
145
146
147
148
149
150
151
152
153
154
155
156
157
158
159
160
161
162
163
164
165
166
167
168
169
170
171
172
173
174
175
176
177
178
179
180
181
182
183
184
185
186
187
188
189
190
191
192
193
194
195
196
197
198
199
200
201
202
203
204
205
206
207
208
209
210
211
212
213
214
215
216
217
218
219
220
221
222
223
224
225
226
227
228
229
230
231
232
233
234
235
236
237
238
239
240
241
242
243
244
245
246
247
248
249
250
251
252
253
254
255
256
257
258
259
260
261
262
263
264
265
266
267
268
269
270
271
272
273
274
275
276
277
278
279
280
281
282
283
284
285
286
287
288
289
290
291
292
293
294
295
296
297
298
299
300
301
302
303
304
305
306
307
308
309
310
311
312
313
314
315
316
317
318
319
320
321
322
323
324
325
326
327
328
329
330
331
332
333
334
335
336
337
338
339
340
341
342
343
344
345
346
347
348
349
350
351
352
353
354
355
356
357
358
359
360
361
362
363
364
365
366
367
368
369
370
371
372
373
374
375
376
377
378
379
380
381
382
383
384
385
386
387
388
389
390
391
392
393
394
395
396
397
398
399
400
401
402
403
404
405
406
407
408
409
410
411
412
413
414
415
416
417
418
419
420
421
422
423
424
425
426
427
428
429
430
431
432
433
434
435
436
437
438
439
440
441
442
443
444
445
446
447
448
449
450
451
452
453
454
455
456
457
458
459
460
461
462
463
464
465
466
467
468
469
470
471
472
473
474
475
476
477
478
479
480
import os
import torch
import torch.nn as nn
import torch.nn.functional as F
import torchvision.transforms as transforms
from torchvision import models
import segmentation_models_pytorch as smp
import numpy as np
import cv2
from PIL import Image
import io
from huggingface_hub import hf_hub_download

# Define model paths
BASE_DIR = os.path.dirname(os.path.abspath(__file__))
MODELS_DIR = os.path.join(BASE_DIR, 'models')
UNET_PATH = os.path.join(MODELS_DIR, 'unet', 'unet_best_advanced.pth')
EFFICIENTNET_PATH = os.path.join(MODELS_DIR, 'efficientnet', 'efficientnet_b3_best.pth')
SPACE_REPO_ID = os.getenv('HF_SPACE_REPO_ID', 'TARAMALIK16/unet-efficient-net-backend')
SPACE_REPO_REVISION = os.getenv('HF_SPACE_REPO_REVISION', 'main')

# Global model instances
unet_model = None
efficientnet_model = None
device = torch.device('cuda' if torch.cuda.is_available() else 'cpu')


# ===========================
# UNet Model Definition
# ===========================
class UNet(nn.Module):
    """UNet architecture for image segmentation"""
    def __init__(self, in_channels=3, out_channels=1):
        super(UNet, self).__init__()
        
        # Encoder
        self.enc1 = self.conv_block(in_channels, 64)
        self.enc2 = self.conv_block(64, 128)
        self.enc3 = self.conv_block(128, 256)
        self.enc4 = self.conv_block(256, 512)
        
        # Bottleneck
        self.bottleneck = self.conv_block(512, 1024)
        
        # Decoder
        self.upconv4 = nn.ConvTranspose2d(1024, 512, kernel_size=2, stride=2)
        self.dec4 = self.conv_block(1024, 512)
        
        self.upconv3 = nn.ConvTranspose2d(512, 256, kernel_size=2, stride=2)
        self.dec3 = self.conv_block(512, 256)
        
        self.upconv2 = nn.ConvTranspose2d(256, 128, kernel_size=2, stride=2)
        self.dec2 = self.conv_block(256, 128)
        
        self.upconv1 = nn.ConvTranspose2d(128, 64, kernel_size=2, stride=2)
        self.dec1 = self.conv_block(128, 64)
        
        # Final output
        self.out = nn.Conv2d(64, out_channels, kernel_size=1)
        
        self.pool = nn.MaxPool2d(kernel_size=2, stride=2)
        
    def conv_block(self, in_ch, out_ch):
        return nn.Sequential(
            nn.Conv2d(in_ch, out_ch, kernel_size=3, padding=1),
            nn.BatchNorm2d(out_ch),
            nn.ReLU(inplace=True),
            nn.Conv2d(out_ch, out_ch, kernel_size=3, padding=1),
            nn.BatchNorm2d(out_ch),
            nn.ReLU(inplace=True)
        )
    
    def forward(self, x):
        # Encoder
        enc1 = self.enc1(x)
        enc2 = self.enc2(self.pool(enc1))
        enc3 = self.enc3(self.pool(enc2))
        enc4 = self.enc4(self.pool(enc3))
        
        # Bottleneck
        bottleneck = self.bottleneck(self.pool(enc4))
        
        # Decoder
        dec4 = self.upconv4(bottleneck)
        dec4 = torch.cat([dec4, enc4], dim=1)
        dec4 = self.dec4(dec4)
        
        dec3 = self.upconv3(dec4)
        dec3 = torch.cat([dec3, enc3], dim=1)
        dec3 = self.dec3(dec3)
        
        dec2 = self.upconv2(dec3)
        dec2 = torch.cat([dec2, enc2], dim=1)
        dec2 = self.dec2(dec2)
        
        dec1 = self.upconv1(dec2)
        dec1 = torch.cat([dec1, enc1], dim=1)
        dec1 = self.dec1(dec1)
        
        return torch.sigmoid(self.out(dec1))


class DoubleConv(nn.Module):
    """(conv => BN => ReLU) * 2"""
    def __init__(self, in_channels, out_channels):
        super().__init__()
        self.net = nn.Sequential(
            nn.Conv2d(in_channels, out_channels, kernel_size=3, padding=1, bias=False),
            nn.BatchNorm2d(out_channels),
            nn.ReLU(inplace=True),
            nn.Conv2d(out_channels, out_channels, kernel_size=3, padding=1, bias=False),
            nn.BatchNorm2d(out_channels),
            nn.ReLU(inplace=True)
        )

    def forward(self, x):
        return self.net(x)


class Down(nn.Module):
    """Downscaling with maxpool then double conv"""
    def __init__(self, in_channels, out_channels):
        super().__init__()
        self.pool_conv = nn.Sequential(
            nn.MaxPool2d(2),
            DoubleConv(in_channels, out_channels)
        )

    def forward(self, x):
        return self.pool_conv(x)


class Up(nn.Module):
    """Upscaling then double conv"""
    def __init__(self, in_channels, out_channels):
        super().__init__()
        self.up = nn.Upsample(scale_factor=2, mode='bilinear', align_corners=True)
        self.conv = DoubleConv(in_channels, out_channels)

    def forward(self, x1, x2):
        x1 = self.up(x1)

        diff_y = x2.size()[2] - x1.size()[2]
        diff_x = x2.size()[3] - x1.size()[3]

        x1 = F.pad(
            x1,
            [
                diff_x // 2,
                diff_x - diff_x // 2,
                diff_y // 2,
                diff_y - diff_y // 2,
            ],
        )

        x = torch.cat([x2, x1], dim=1)
        return self.conv(x)


class UNetLegacy(nn.Module):
    """UNet variant matching the precise dimensions of the trained UNetSmall checkpoint."""
    def __init__(self, n_channels=3, n_classes=1):
        super().__init__()
        # EXACT SHAPES FOR 64-CHANNEL BASE
        self.inc = DoubleConv(n_channels, 64)
        self.down1 = Down(64, 128)
        self.down2 = Down(128, 256)
        self.down3 = Down(256, 512)
        self.down4 = Down(512, 512)  # Custom flat bottleneck
        
        # Up blocks
        self.up1 = Up(1024, 256)  
        self.up2 = Up(512, 128)   
        self.up3 = Up(256, 64)    
        self.up4 = Up(128, 64)    
        
        self.outc = nn.Conv2d(64, n_classes, kernel_size=1)

    def forward(self, x):
        x1 = self.inc(x)
        x2 = self.down1(x1)
        x3 = self.down2(x2)
        x4 = self.down3(x3)
        x5 = self.down4(x4)
        x = self.up1(x5, x4)
        x = self.up2(x, x3)
        x = self.up3(x, x2)
        x = self.up4(x, x1)
        logits = self.outc(x)
        return torch.sigmoid(logits)


def _extract_state_dict(checkpoint):
    """Extract model state_dict from various checkpoint formats."""
    if isinstance(checkpoint, dict):
        for key in ('state_dict', 'model_state', 'model_state_dict', 'net', 'model'):
            if key in checkpoint and isinstance(checkpoint[key], dict):
                return checkpoint[key]
    return checkpoint


def _load_checkpoint(path):
    """Load trusted local checkpoints in a PyTorch-version-safe way."""
    try:
        return torch.load(path, map_location=device, weights_only=False)
    except TypeError:
        return torch.load(path, map_location=device)


def _is_git_lfs_pointer(path):
    """Detect Git LFS pointer files masquerading as checkpoints."""
    try:
        with open(path, 'rb') as file_handle:
            return file_handle.read(64).startswith(b'version https://git-lfs.github.com/spec/v1')
    except OSError:
        return False


def _resolve_checkpoint_path(local_path, repo_filename):
    """Return a real checkpoint path, downloading from the Space repo if needed."""
    if os.path.exists(local_path) and not _is_git_lfs_pointer(local_path):
        return local_path

    downloaded_path = hf_hub_download(
        repo_id=SPACE_REPO_ID,
        repo_type='space',
        revision=SPACE_REPO_REVISION,
        filename=repo_filename,
    )
    return downloaded_path


def _looks_like_legacy_unet(state_dict):
    """Detect legacy UNet checkpoints by key namespace."""
    if not isinstance(state_dict, dict):
        return False
    keys = list(state_dict.keys())
    return any(k.startswith('inc.') for k in keys) and any(k.startswith('up1.') for k in keys)


def _looks_like_smp_unet(state_dict):
    """Detect segmentation_models_pytorch-style UNet checkpoints."""
    if not isinstance(state_dict, dict):
        return False
    keys = list(state_dict.keys())
    return any(k.startswith('encoder._conv_stem') for k in keys) and any(k.startswith('decoder.blocks.') for k in keys)


# ===========================
# EfficientNet Model Setup
# ===========================
def create_efficientnet_model(num_classes=1, nested_classifier=False):
    """Create EfficientNet-B3 model for classification (binary output)"""
    model = models.efficientnet_b3(weights=None)
    num_features = model.classifier[1].in_features
    if nested_classifier:
        # Matches checkpoint keys like classifier.1.1.weight
        model.classifier = nn.Sequential(
            nn.Dropout(p=0.3, inplace=True),
            nn.Sequential(
                nn.Dropout(p=0.3, inplace=True),
                nn.Linear(num_features, num_classes)
            )
        )
    else:
        model.classifier = nn.Sequential(
            nn.Dropout(p=0.3, inplace=True),
            nn.Linear(num_features, num_classes)
        )
    return model


class SMPUNet(smp.Unet):
    """SMP UNet variant that returns probability maps for inference."""
    def forward(self, x):
        logits = super().forward(x)
        return torch.sigmoid(logits)


def create_smp_unet_model():
    """Create SMP UNet matching the new advanced UNet checkpoint."""
    return SMPUNet(
        encoder_name='efficientnet-b0',
        encoder_weights=None,
        in_channels=3,
        classes=1,
        activation=None
    )


# ===========================
# Model Loading Functions
# ===========================
def load_models():
    """Load UNet and EfficientNet models into memory."""
    global unet_model, efficientnet_model
    
    print("πŸ”„ Loading ML models...")
    
    # Load UNet
    try:
        if os.path.exists(UNET_PATH):
            checkpoint_path = _resolve_checkpoint_path(UNET_PATH, 'models/unet/unet_best_advanced.pth')
            checkpoint = _load_checkpoint(checkpoint_path)
            unet_state = _extract_state_dict(checkpoint)
            loaded_unet_model = None

            if _looks_like_smp_unet(unet_state):
                loaded_unet_model = create_smp_unet_model()
            elif _looks_like_legacy_unet(unet_state):
                loaded_unet_model = UNetLegacy(n_channels=3, n_classes=1)
            else:
                loaded_unet_model = UNet(in_channels=3, out_channels=1)

            loaded_unet_model.load_state_dict(unet_state)
            loaded_unet_model.to(device)
            loaded_unet_model.eval()
            unet_model = loaded_unet_model
            print(f"βœ… UNet model loaded from {UNET_PATH}")
        else:
            print(f"⚠️  UNet model not found at {UNET_PATH}")
    except Exception as e:
        print(f"❌ Failed to load UNet: {e}")
    
    # Load EfficientNet
    try:
        if os.path.exists(EFFICIENTNET_PATH):
            checkpoint_path = _resolve_checkpoint_path(EFFICIENTNET_PATH, 'models/efficientnet/efficientnet_b3_best.pth')
            checkpoint = _load_checkpoint(checkpoint_path)
            eff_state = _extract_state_dict(checkpoint)
            nested_classifier = isinstance(eff_state, dict) and 'classifier.1.1.weight' in eff_state
            loaded_efficientnet_model = create_efficientnet_model(num_classes=1, nested_classifier=nested_classifier)
            # Handle different checkpoint formats
            loaded_efficientnet_model.load_state_dict(eff_state)
            loaded_efficientnet_model.to(device)
            loaded_efficientnet_model.eval()
            efficientnet_model = loaded_efficientnet_model
            print(f"βœ… EfficientNet model loaded from {EFFICIENTNET_PATH}")
        else:
            print(f"⚠️  EfficientNet model not found at {EFFICIENTNET_PATH}")
    except Exception as e:
        print(f"❌ Failed to load EfficientNet: {e}")

    if unet_model is None or efficientnet_model is None:
        raise RuntimeError("Required models failed to load (UNet and/or EfficientNet).")
    
    print("πŸŽ‰ Model loading complete!")


# ===========================
# Image Preprocessing & Fusion
# ===========================
def apply_mask_overlay(img_rgb, mask_gray, alpha=0.35):
    """Highlights the U-Net vessels in red over the original image."""
    mask_resized = cv2.resize(mask_gray, (img_rgb.shape[1], img_rgb.shape[0]), interpolation=cv2.INTER_NEAREST)
    red_mask = np.zeros_like(img_rgb)
    red_mask[..., 0] = mask_resized  # Add to Red channel
    blended = (img_rgb.astype(np.float32) * (1.0 - alpha) + red_mask.astype(np.float32) * alpha)
    return np.clip(blended, 0, 255).astype(np.uint8)

def get_efficientnet_transforms():
    """Exact transforms used during EfficientNet training"""
    return transforms.Compose([
        transforms.Resize((300, 300)), # EfficientNet-B3 requires 300x300
        transforms.ToTensor(),
        transforms.Normalize(mean=[0.485, 0.456, 0.406], std=[0.229, 0.224, 0.225])
    ])

def get_unet_transforms():
    """Exact transforms used during UNet training"""
    return transforms.Compose([
        transforms.Resize((384, 384)), # UNet trained on 384x384
        transforms.ToTensor(),
        transforms.Normalize(mean=[0.485, 0.456, 0.406], std=[0.229, 0.224, 0.225])
    ])


# ===========================
# Prediction Functions
# ===========================
def predict_from_image(image_bytes):
    """
    1. Pass raw image through UNet to get vessels
    2. Overlay vessels in red onto the original image
    3. Pass the fused image to EfficientNet for risk prediction
    """
    if efficientnet_model is None or unet_model is None:
        raise ValueError("Models not fully loaded")
    
    try:
        # 1. Load the raw image
        raw_pil = Image.open(io.BytesIO(image_bytes)).convert('RGB')
        raw_cv2 = np.array(raw_pil) # Convert to CV2 format for overlay later
        
        # 2. Get UNet Segmentation Mask
        unet_t = get_unet_transforms()
        unet_input = unet_t(raw_pil).unsqueeze(0).to(device)
        
        with torch.no_grad():
            unet_output = unet_model(unet_input)
            # Binarize the mask at 0.5 threshold
            mask = (unet_output.squeeze().cpu().numpy() > 0.5).astype(np.uint8) * 255
            
        # 3. Fuse the Mask with the Original Image
        fused_cv2 = apply_mask_overlay(raw_cv2, mask)
        fused_pil = Image.fromarray(fused_cv2)
        
        # 4. Prepare Fused Image for EfficientNet
        eff_t = get_efficientnet_transforms()
        eff_input = eff_t(fused_pil).unsqueeze(0).to(device)
        
        # 5. Make Final Prediction
        with torch.no_grad():
            outputs = efficientnet_model(eff_input)
            prob = torch.sigmoid(outputs)[0][0].item() * 100
            
            # --- PIECEWISE CONFIDENCE MATH ---
            if prob >= 40:
                confidence = ((prob - 40.0) / 60.0) * 100
            else:
                confidence = ((40.0 - prob) / 40.0) * 100
            
            # Using your optimized clinical thresholds
            if prob >= 70:
                risk_level = "High"
            elif prob >= 40:
                risk_level = "Medium"
            else:
                risk_level = "Low"
                
            return {
                'risk_score': round(prob, 2),
                'risk_level': risk_level,
                'confidence': round(confidence, 2),
                'prediction': int(prob >= 40)
            }
    
    except Exception as e:
        raise Exception(f"Image prediction failed: {str(e)}")


def segment_image_with_unet(image_bytes):
    """
    Apply UNet segmentation to identify regions of interest
    
    Args:
        image_bytes: Raw image bytes
        
    Returns:
        numpy array: Segmentation mask
    """
    if unet_model is None:
        raise ValueError("UNet model not loaded")
    
    try:
        raw_pil = Image.open(io.BytesIO(image_bytes)).convert('RGB')
        unet_t = get_unet_transforms()
        image_tensor = unet_t(raw_pil).unsqueeze(0).to(device)
        
        with torch.no_grad():
            segmentation = unet_model(image_tensor)
            mask = segmentation.squeeze().cpu().numpy()
            
        return mask
    
    except Exception as e:
        raise Exception(f"Image segmentation failed: {str(e)}")


# ===========================
# Initialization
# ===========================
def initialize_models():
    """Initialize all models on startup"""
    try:
        load_models()
        return True
    except Exception as e:
        print(f"❌ Model initialization failed: {e}")
        return False