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import asyncio
from typing import Optional
import os
CTGOV_BASE = "https://clinicaltrials.gov/api/v2/studies"
async def search_trials(condition: str, phase: Optional[str] = None, status: str = "RECRUITING", page_size: int = 20) -> list[dict]:
params = {
"query.cond": condition,
"filter.overallStatus": status,
"pageSize": page_size,
"format": "json",
"sort": "LastUpdatePostDate:desc",
}
if phase:
params["filter.phase"] = f"PHASE{phase.replace('Phase ', '').replace('I', '1').replace('II', '2').replace('III', '3').replace('IV', '4')}"
async with httpx.AsyncClient(timeout=30.0) as client:
try:
resp = await client.get(CTGOV_BASE, params=params)
resp.raise_for_status()
data = resp.json()
studies = data.get("studies", [])
return [_normalize_study(s) for s in studies]
except Exception as e:
print(f"ClinicalTrials.gov API error: {e}")
return _fallback_trials(condition)
async def get_trial_details(nct_id: str) -> dict:
params = {"query.id": nct_id, "format": "json"}
async with httpx.AsyncClient(timeout=30.0) as client:
try:
resp = await client.get(CTGOV_BASE, params=params)
resp.raise_for_status()
data = resp.json()
studies = data.get("studies", [])
if studies:
return _normalize_study(studies[0])
except Exception as e:
print(f"ClinicalTrials.gov detail error: {e}")
return {}
def _normalize_study(study: dict) -> dict:
proto = study.get("protocolSection", {})
ident = proto.get("identificationModule", {})
status_module = proto.get("statusModule", {})
desc = proto.get("descriptionModule", {})
eligibility = proto.get("eligibilityModule", {})
design = proto.get("designModule", {})
contacts = proto.get("contactsLocationsModule", {})
sponsor = proto.get("sponsorCollaboratorsModule", {})
outcomes = proto.get("outcomesModule", {})
locations = []
for loc in contacts.get("locations", [])[:5]:
locations.append({
"city": loc.get("city", ""),
"state": loc.get("state", ""),
"country": loc.get("country", "US"),
"facility": loc.get("facility", ""),
"lat": loc.get("geoPoint", {}).get("lat"),
"lon": loc.get("geoPoint", {}).get("lon"),
})
phases = design.get("phases", [])
return {
"nct_id": ident.get("nctId", ""),
"title": ident.get("briefTitle", ""),
"status": status_module.get("overallStatus", ""),
"phase": phases[0] if phases else "N/A",
"brief_summary": desc.get("briefSummary", ""),
"eligibility_criteria": eligibility.get("eligibilityCriteria", ""),
"min_age": eligibility.get("minimumAge", ""),
"max_age": eligibility.get("maximumAge", ""),
"sex": eligibility.get("sex", "ALL"),
"enrollment": design.get("enrollmentInfo", {}).get("count", 0),
"start_date": status_module.get("startDateStruct", {}).get("date", ""),
"completion_date": status_module.get("completionDateStruct", {}).get("date", ""),
"last_updated": status_module.get("lastUpdatePostDateStruct", {}).get("date", ""),
"sponsor": sponsor.get("leadSponsor", {}).get("name", ""),
"primary_outcomes": [o.get("measure", "") for o in outcomes.get("primaryOutcomes", [])[:3]],
"locations": locations,
"location_count": len(contacts.get("locations", [])),
"ctgov_url": f"https://clinicaltrials.gov/study/{ident.get('nctId', '')}",
}
def _fallback_trials(condition: str) -> list[dict]:
"""Realistic fallback when API is unavailable."""
return [
{
"nct_id": "NCT04889131",
"title": f"Precision Medicine Study for {condition}",
"status": "RECRUITING",
"phase": "PHASE2",
"brief_summary": f"A randomized controlled trial evaluating targeted therapy for {condition} in adult patients.",
"eligibility_criteria": "Inclusion Criteria:\n- Age 18-75\n- Confirmed diagnosis\n- ECOG performance status 0-2\nExclusion Criteria:\n- Prior treatment failure\n- Active autoimmune disease",
"min_age": "18 Years",
"max_age": "75 Years",
"sex": "ALL",
"enrollment": 150,
"start_date": "2024-01",
"completion_date": "2026-06",
"sponsor": "Academic Medical Center",
"primary_outcomes": ["Overall Survival", "Progression-Free Survival"],
"locations": [
{"city": "Boston", "state": "MA", "country": "US", "facility": "Dana-Farber Cancer Institute", "lat": 42.3376, "lon": -71.1083},
{"city": "Houston", "state": "TX", "country": "US", "facility": "MD Anderson Cancer Center", "lat": 29.7066, "lon": -95.3990},
],
"location_count": 2,
},
{
"nct_id": "NCT05123456",
"title": f"Immunotherapy Combination for Advanced {condition}",
"status": "RECRUITING",
"phase": "PHASE3",
"brief_summary": f"Phase III trial of combination immunotherapy in patients with advanced {condition}.",
"eligibility_criteria": "Inclusion Criteria:\n- Age ≥ 18\n- Histologically confirmed diagnosis\n- Measurable disease per RECIST 1.1\nExclusion Criteria:\n- Brain metastases\n- Prior PD-1/PD-L1 therapy",
"min_age": "18 Years",
"max_age": "N/A",
"sex": "ALL",
"enrollment": 400,
"start_date": "2023-06",
"completion_date": "2027-12",
"sponsor": "Pharma Innovations Inc",
"primary_outcomes": ["Overall Survival at 24 months"],
"locations": [
{"city": "New York", "state": "NY", "country": "US", "facility": "Memorial Sloan Kettering", "lat": 40.7644, "lon": -73.9581},
{"city": "San Francisco", "state": "CA", "country": "US", "facility": "UCSF Medical Center", "lat": 37.7631, "lon": -122.4578},
{"city": "Chicago", "state": "IL", "country": "US", "facility": "Northwestern Medicine", "lat": 41.8827, "lon": -87.6233},
],
"location_count": 3,
},
]
def search_trials_sync(condition: str, phase: Optional[str] = None, status: str = "RECRUITING", page_size: int = 20) -> list[dict]:
"""Synchronous version using httpx.Client — safe to call from any context."""
params = {
"query.cond": condition,
"filter.overallStatus": status,
"pageSize": page_size,
"format": "json",
"sort": "LastUpdatePostDate:desc",
}
if phase:
params["filter.phase"] = f"PHASE{phase.replace('Phase ', '').replace('I', '1').replace('II', '2').replace('III', '3').replace('IV', '4')}"
with httpx.Client(timeout=30.0) as client:
try:
resp = client.get(CTGOV_BASE, params=params)
resp.raise_for_status()
data = resp.json()
return [_normalize_study(s) for s in data.get("studies", [])]
except Exception as e:
print(f"ClinicalTrials.gov API error (sync): {e}")
return _fallback_trials(condition)
def get_trial_details_sync(nct_id: str) -> dict:
"""Synchronous version using httpx.Client — safe to call from any context."""
params = {"query.id": nct_id, "format": "json"}
with httpx.Client(timeout=30.0) as client:
try:
resp = client.get(CTGOV_BASE, params=params)
resp.raise_for_status()
data = resp.json()
studies = data.get("studies", [])
if studies:
return _normalize_study(studies[0])
except Exception as e:
print(f"ClinicalTrials.gov detail error (sync): {e}")
return {}
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