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============================================================
ClinicalMatch AI — Graph Seeder v2
100 k synthetic patients · 20 oncology conditions
============================================================

[1/5] Seeding clinical trials from ClinicalTrials.gov...
  breast cancer: 50 trials fetched
  prostate cancer: 50 trials fetched
  non-small cell lung cancer: 50 trials fetched
  colorectal cancer: 50 trials fetched
  ovarian cancer: 50 trials fetched
  melanoma: 50 trials fetched
  leukemia: 50 trials fetched
  lymphoma: 50 trials fetched
  glioblastoma: 50 trials fetched
  pancreatic cancer: 50 trials fetched
  bladder cancer: 50 trials fetched
  renal cell carcinoma: 50 trials fetched
  thyroid cancer: 50 trials fetched
  multiple myeloma: 50 trials fetched
  endometrial cancer: 50 trials fetched
  cervical cancer: 50 trials fetched
  gastric cancer: 50 trials fetched
  hepatocellular carcinoma: 50 trials fetched
  head and neck cancer: 50 trials fetched
  sarcoma: 50 trials fetched
  Total trials seeded: 1000

[2/5] Seeding medications from RxNorm...
  trastuzumab: 5 RxCUI concepts
  pembrolizumab: 5 RxCUI concepts
  nivolumab: 5 RxCUI concepts
  osimertinib: 4 RxCUI concepts
  olaparib: 5 RxCUI concepts
  enzalutamide: 5 RxCUI concepts
  bevacizumab: 5 RxCUI concepts
  rituximab: 5 RxCUI concepts
  imatinib: 5 RxCUI concepts
  dabrafenib: 5 RxCUI concepts
  vemurafenib: 2 RxCUI concepts
  atezolizumab: 5 RxCUI concepts
  durvalumab: 4 RxCUI concepts
  cetuximab: 4 RxCUI concepts
  erlotinib: 5 RxCUI concepts
  capecitabine: 4 RxCUI concepts
  Total medications seeded: 16

[3/5] Seeding diagnoses from ICD-10 CM...
  ICD-10 C50: 20 codes
  ICD-10 C61: 1 codes
  ICD-10 C34: 16 codes
  ICD-10 C18: 10 codes
  ICD-10 C56: 4 codes
  ICD-10 C43: 20 codes
  ICD-10 C91: 20 codes
  ICD-10 C85: 20 codes
  ICD-10 C71: 10 codes
  ICD-10 C25: 8 codes
  Total diagnoses seeded: 129

[4/5] Seeding supporting literature from PubMed...
  breast cancer: 5 publications linked
  prostate cancer: 5 publications linked
  non-small cell lung cancer: 5 publications linked
  colorectal cancer: 5 publications linked
  ovarian cancer: 5 publications linked
  Total publications seeded: 25

[5/5] Seeding biomarkers (curated from COSMIC/NCIT)...
  57 biomarkers seeded and linked to conditions

[+] Deriving eligibility relationships...
  Eligibility relationships derived.

[6/6] Generating 100,000 clinically-informed synthetic patients...
      (SEER incidence weights · TCGA biomarker prevalence · US Census demographics)
  breast cancer: 17,222 patients — already done, skipping
  non-small cell lung cancer: 14,444 patients (40 trials)  [resuming from 4,000]
    ↳ wrote 10,444 patients  |  total so far: 31,666/100,000  |  edges: 351,181
  prostate cancer: 10,556 patients (44 trials)
    ↳ wrote 10,556 patients  |  total so far: 42,222/100,000  |  edges: 766,259
  colorectal cancer: 9,444 patients (34 trials)
    ↳ wrote 9,444 patients  |  total so far: 51,666/100,000  |  edges: 1,047,777
  melanoma: 6,111 patients (56 trials)
    ↳ wrote 6,111 patients  |  total so far: 57,777/100,000  |  edges: 1,329,267
  bladder cancer: 5,000 patients (41 trials)
    ↳ wrote 5,000 patients  |  total so far: 62,777/100,000  |  edges: 1,509,909
  renal cell carcinoma: 4,667 patients (42 trials)
    ↳ wrote 4,667 patients  |  total so far: 67,444/100,000  |  edges: 1,687,802
  lymphoma: 4,667 patients (46 trials)
    ↳ wrote 4,667 patients  |  total so far: 72,111/100,000  |  edges: 1,847,153
  endometrial cancer: 4,222 patients (40 trials)
    ↳ wrote 4,222 patients  |  total so far: 76,333/100,000  |  edges: 1,992,865
  leukemia: 3,889 patients (27 trials)
    ↳ wrote 3,889 patients  |  total so far: 80,222/100,000  |  edges: 2,071,433
  pancreatic cancer: 3,667 patients (35 trials)
    ↳ wrote 3,667 patients  |  total so far: 83,889/100,000  |  edges: 2,172,901
  thyroid cancer: 3,333 patients (41 trials)
    ↳ wrote 3,333 patients  |  total so far: 87,222/100,000  |  edges: 2,302,009
  multiple myeloma: 2,778 patients (50 trials)
    ↳ wrote 2,778 patients  |  total so far: 90,000/100,000  |  edges: 2,415,994
  gastric cancer: 2,000 patients (38 trials)
    ↳ wrote 2,000 patients  |  total so far: 92,000/100,000  |  edges: 2,474,564
  ovarian cancer: 2,000 patients (29 trials)
    ↳ wrote 2,000 patients  |  total so far: 94,000/100,000  |  edges: 2,516,658
  hepatocellular carcinoma: 1,667 patients (47 trials)
    ↳ wrote 1,667 patients  |  total so far: 95,667/100,000  |  edges: 2,578,834
  glioblastoma: 1,333 patients (45 trials)
    ↳ wrote 1,333 patients  |  total so far: 97,000/100,000  |  edges: 2,623,714
  head and neck cancer: 1,333 patients (49 trials)
    ↳ wrote 1,333 patients  |  total so far: 98,333/100,000  |  edges: 2,677,369
  cervical cancer: 889 patients (10 trials)
    ↳ wrote 889 patients  |  total so far: 99,222/100,000  |  edges: 2,685,508
  sarcoma: 778 patients (50 trials)
    ↳ wrote 778 patients  |  total so far: 100,000/100,000  |  edges: 2,717,650

  ✓ Total patients: 100,000
  ✓ Total ELIGIBLE_FOR edges: 2,717,650

============================================================
Seeding complete in 21.1 min
  Trials:       1000
  Medications:  16
  Diagnoses:    129
  Publications: 25
  Biomarkers:   57
  Patients:     100,000
============================================================