============================================================ ClinicalMatch AI — Graph Seeder v2 100 k synthetic patients · 20 oncology conditions ============================================================ [1/5] Seeding clinical trials from ClinicalTrials.gov... breast cancer: 50 trials fetched prostate cancer: 50 trials fetched non-small cell lung cancer: 50 trials fetched colorectal cancer: 50 trials fetched ovarian cancer: 50 trials fetched melanoma: 50 trials fetched leukemia: 50 trials fetched lymphoma: 50 trials fetched glioblastoma: 50 trials fetched pancreatic cancer: 50 trials fetched bladder cancer: 50 trials fetched renal cell carcinoma: 50 trials fetched thyroid cancer: 50 trials fetched multiple myeloma: 50 trials fetched endometrial cancer: 50 trials fetched cervical cancer: 50 trials fetched gastric cancer: 50 trials fetched hepatocellular carcinoma: 50 trials fetched head and neck cancer: 50 trials fetched sarcoma: 50 trials fetched Total trials seeded: 1000 [2/5] Seeding medications from RxNorm... trastuzumab: 5 RxCUI concepts pembrolizumab: 5 RxCUI concepts nivolumab: 5 RxCUI concepts osimertinib: 4 RxCUI concepts olaparib: 5 RxCUI concepts enzalutamide: 5 RxCUI concepts bevacizumab: 5 RxCUI concepts rituximab: 5 RxCUI concepts imatinib: 5 RxCUI concepts dabrafenib: 5 RxCUI concepts vemurafenib: 2 RxCUI concepts atezolizumab: 5 RxCUI concepts durvalumab: 4 RxCUI concepts cetuximab: 4 RxCUI concepts erlotinib: 5 RxCUI concepts capecitabine: 4 RxCUI concepts Total medications seeded: 16 [3/5] Seeding diagnoses from ICD-10 CM... ICD-10 C50: 20 codes ICD-10 C61: 1 codes ICD-10 C34: 16 codes ICD-10 C18: 10 codes ICD-10 C56: 4 codes ICD-10 C43: 20 codes ICD-10 C91: 20 codes ICD-10 C85: 20 codes ICD-10 C71: 10 codes ICD-10 C25: 8 codes Total diagnoses seeded: 129 [4/5] Seeding supporting literature from PubMed... breast cancer: 5 publications linked prostate cancer: 5 publications linked non-small cell lung cancer: 5 publications linked colorectal cancer: 5 publications linked ovarian cancer: 5 publications linked Total publications seeded: 25 [5/5] Seeding biomarkers (curated from COSMIC/NCIT)... 57 biomarkers seeded and linked to conditions [+] Deriving eligibility relationships... Eligibility relationships derived. [6/6] Generating 100,000 clinically-informed synthetic patients... (SEER incidence weights · TCGA biomarker prevalence · US Census demographics) breast cancer: 17,222 patients — already done, skipping non-small cell lung cancer: 14,444 patients (40 trials) [resuming from 4,000] ↳ wrote 10,444 patients | total so far: 31,666/100,000 | edges: 351,181 prostate cancer: 10,556 patients (44 trials) ↳ wrote 10,556 patients | total so far: 42,222/100,000 | edges: 766,259 colorectal cancer: 9,444 patients (34 trials) ↳ wrote 9,444 patients | total so far: 51,666/100,000 | edges: 1,047,777 melanoma: 6,111 patients (56 trials) ↳ wrote 6,111 patients | total so far: 57,777/100,000 | edges: 1,329,267 bladder cancer: 5,000 patients (41 trials) ↳ wrote 5,000 patients | total so far: 62,777/100,000 | edges: 1,509,909 renal cell carcinoma: 4,667 patients (42 trials) ↳ wrote 4,667 patients | total so far: 67,444/100,000 | edges: 1,687,802 lymphoma: 4,667 patients (46 trials) ↳ wrote 4,667 patients | total so far: 72,111/100,000 | edges: 1,847,153 endometrial cancer: 4,222 patients (40 trials) ↳ wrote 4,222 patients | total so far: 76,333/100,000 | edges: 1,992,865 leukemia: 3,889 patients (27 trials) ↳ wrote 3,889 patients | total so far: 80,222/100,000 | edges: 2,071,433 pancreatic cancer: 3,667 patients (35 trials) ↳ wrote 3,667 patients | total so far: 83,889/100,000 | edges: 2,172,901 thyroid cancer: 3,333 patients (41 trials) ↳ wrote 3,333 patients | total so far: 87,222/100,000 | edges: 2,302,009 multiple myeloma: 2,778 patients (50 trials) ↳ wrote 2,778 patients | total so far: 90,000/100,000 | edges: 2,415,994 gastric cancer: 2,000 patients (38 trials) ↳ wrote 2,000 patients | total so far: 92,000/100,000 | edges: 2,474,564 ovarian cancer: 2,000 patients (29 trials) ↳ wrote 2,000 patients | total so far: 94,000/100,000 | edges: 2,516,658 hepatocellular carcinoma: 1,667 patients (47 trials) ↳ wrote 1,667 patients | total so far: 95,667/100,000 | edges: 2,578,834 glioblastoma: 1,333 patients (45 trials) ↳ wrote 1,333 patients | total so far: 97,000/100,000 | edges: 2,623,714 head and neck cancer: 1,333 patients (49 trials) ↳ wrote 1,333 patients | total so far: 98,333/100,000 | edges: 2,677,369 cervical cancer: 889 patients (10 trials) ↳ wrote 889 patients | total so far: 99,222/100,000 | edges: 2,685,508 sarcoma: 778 patients (50 trials) ↳ wrote 778 patients | total so far: 100,000/100,000 | edges: 2,717,650 ✓ Total patients: 100,000 ✓ Total ELIGIBLE_FOR edges: 2,717,650 ============================================================ Seeding complete in 21.1 min Trials: 1000 Medications: 16 Diagnoses: 129 Publications: 25 Biomarkers: 57 Patients: 100,000 ============================================================