import gradio as gr

# Custom Premium CSS for medical dashboard styling
GRADIO_CUSTOM_CSS = """
/* Import Inter Font */
@import url('https://fonts.googleapis.com/css2?family=Inter:wght@300;400;500;600;700;800;900&display=swap');

/* Main Container Styles - Deep Obsidian Background */
.gradio-container {
    font-family: 'Inter', -apple-system, BlinkMacSystemFont, "Segoe UI", Roboto, Helvetica, Arial, sans-serif !important;
    background: radial-gradient(circle at 50% 0%, #101626 0%, #060912 100%) !important;
    color: #e2e8f0 !important;
    max-width: 1400px !important;
    margin: auto !important;
    padding: 24px !important;
    border: none !important;
    box-shadow: none !important;
}

/* Typography & Headers */
h1, h2, h3, h4, h5, h6 {
    font-family: 'Inter', sans-serif !important;
    font-weight: 700 !important;
    color: #f1f5f9 !important;
    letter-spacing: -0.02em !important;
}

.clinical-header {
    text-align: center;
    margin-bottom: 30px;
    padding-bottom: 24px;
    border-bottom: 1px solid rgba(255, 255, 255, 0.05);
}

.clinical-header h1 {
    font-size: 3rem !important;
    font-weight: 900 !important;
    background: linear-gradient(135deg, #14b8a6 0%, #3b82f6 50%, #8b5cf6 100%) !important;
    -webkit-background-clip: text !important;
    -webkit-text-fill-color: transparent !important;
    letter-spacing: -0.06em !important;
    margin-bottom: 12px !important;
    text-shadow: 0 0 40px rgba(59, 130, 246, 0.15) !important;
}

.clinical-header p {
    font-size: 1.15rem !important;
    color: #94a3b8 !important;
    font-weight: 400 !important;
    max-width: 700px;
    margin: 0 auto !important;
    line-height: 1.5;
}

/* UI Card Glassmorphism Elements */
.glass-panel, .block, .contain {
    background: rgba(13, 20, 35, 0.45) !important;
    backdrop-filter: blur(20px) !important;
    -webkit-backdrop-filter: blur(20px) !important;
    border: 1px solid rgba(255, 255, 255, 0.06) !important;
    border-radius: 16px !important;
    box-shadow: 0 8px 32px 0 rgba(0, 0, 0, 0.3) !important;
    transition: all 0.3s cubic-bezier(0.16, 1, 0.3, 1) !important;
}

.glass-panel:hover {
    border-color: rgba(255, 255, 255, 0.1) !important;
    box-shadow: 0 12px 40px 0 rgba(0, 0, 0, 0.4) !important;
}

/* Button & Interactions */
.run-btn {
    background: linear-gradient(135deg, #14b8a6 0%, #0d9488 100%) !important;
    color: white !important;
    font-weight: 700 !important;
    border: none !important;
    border-radius: 12px !important;
    font-size: 1rem !important;
    letter-spacing: 0.02em !important;
    box-shadow: 0 0 20px rgba(20, 184, 166, 0.25) !important;
    transition: all 0.2s cubic-bezier(0.16, 1, 0.3, 1) !important;
    padding: 14px 24px !important;
    text-transform: uppercase !important;
    cursor: pointer !important;
}

.run-btn:hover {
    transform: translateY(-2px) !important;
    box-shadow: 0 0 30px rgba(20, 184, 166, 0.5) !important;
    filter: brightness(1.1) !important;
}

.run-btn:active {
    transform: translateY(1px) !important;
}

/* Custom Pathology Report Markdown Styling */
.report-card {
    background: rgba(15, 23, 42, 0.35) !important;
    border: 1px solid rgba(255, 255, 255, 0.04) !important;
    border-radius: 12px !important;
    padding: 24px !important;
    color: #cbd5e1 !important;
    line-height: 1.6 !important;
    font-size: 0.95rem !important;
}

.report-card h3 {
    color: #14b8a6 !important;
    font-size: 1.2rem !important;
    margin-top: 0 !important;
    margin-bottom: 12px !important;
    border-bottom: 1px solid rgba(20, 184, 166, 0.15) !important;
    padding-bottom: 8px !important;
}

.report-card strong {
    color: #f1f5f9 !important;
}

/* Custom Cards for FAISS Matches */
.case-card {
    background: rgba(15, 23, 42, 0.55);
    border: 1px solid rgba(255, 255, 255, 0.05);
    border-radius: 12px;
    padding: 16px 20px;
    margin-bottom: 12px;
    display: flex;
    justify-content: space-between;
    align-items: center;
    box-shadow: 0 4px 20px rgba(0, 0, 0, 0.15);
    transition: all 0.25s cubic-bezier(0.16, 1, 0.3, 1);
}

.case-card:hover {
    border-color: rgba(255, 255, 255, 0.12);
    transform: translateX(6px);
    background: rgba(20, 30, 50, 0.6);
}

.case-badge-msih {
    background: rgba(248, 113, 113, 0.12) !important;
    color: #f87171 !important;
    padding: 3px 10px !important;
    border-radius: 6px !important;
    font-size: 0.72rem !important;
    font-weight: 700 !important;
    border: 1px solid rgba(248, 113, 113, 0.25) !important;
    text-transform: uppercase !important;
    letter-spacing: 0.05em !important;
}

.case-badge-mss {
    background: rgba(16, 185, 129, 0.1) !important;
    color: #34d399 !important;
    padding: 3px 10px !important;
    border-radius: 6px !important;
    font-size: 0.72rem !important;
    font-weight: 700 !important;
    border: 1px solid rgba(16, 185, 129, 0.2) !important;
    text-transform: uppercase !important;
    letter-spacing: 0.05em !important;
}

/* Tab & Input Customizations */
.tabs {
    border-bottom: 1px solid rgba(255, 255, 255, 0.06) !important;
}

.tab-nav button {
    font-weight: 600 !important;
    font-size: 0.85rem !important;
    color: #94a3b8 !important;
    transition: all 0.2s ease !important;
}

.tab-nav button.selected {
    color: #14b8a6 !important;
    border-bottom-color: #14b8a6 !important;
    background: rgba(20, 184, 166, 0.05) !important;
}

/* Animations */
@keyframes pulse {
    0% { opacity: 0.4; }
    50% { opacity: 1; }
    100% { opacity: 0.4; }
}

.status-pulse {
    animation: pulse 2.5s infinite;
}
"""

SYSTEM_STATUS_CONSOLE = """
<div style="display: flex; justify-content: space-between; align-items: center; background: rgba(10, 15, 28, 0.65); backdrop-filter: blur(12px); -webkit-backdrop-filter: blur(12px); border: 1px solid rgba(255, 255, 255, 0.06); border-radius: 12px; padding: 12px 24px; margin-bottom: 24px; box-shadow: 0 4px 30px rgba(0,0,0,0.35);">
    <div style="display: flex; align-items: center; gap: 10px;">
        <span class="status-pulse" style="display: inline-block; width: 9px; height: 9px; background-color: #10b981; border-radius: 50%; box-shadow: 0 0 12px #10b981;"></span>
        <span style="font-family: 'Inter', sans-serif; font-size: 0.78rem; font-weight: 700; color: #10b981; letter-spacing: 0.06em; text-transform: uppercase;">CLINICAL CORE: ONLINE</span>
    </div>
    <div style="display: flex; gap: 28px; font-family: 'Inter', sans-serif; font-size: 0.75rem; color: #94a3b8; font-weight: 600;">
        <div>PIPELINE: <span style="color: #f1f5f9; font-weight: 700; font-family: monospace;">ZeroGPU / CUDA v12.1</span></div>
        <div>FUSION: <span style="color: #f1f5f9; font-weight: 700;">PathViT-384 + MedSigLIP-1152 (1536-dim Representation)</span></div>
        <div>DIAGNOSTICS: <span style="color: #8b5cf6; font-weight: 700;">MEDGEMMA-4B-IT ACTIVE</span></div>
    </div>
</div>
"""

def format_retrieved_cases_html(cases: list) -> str:
    """
    Synthesizes similar historical cases retrieved via FAISS into beautiful, 
    clinical-grade dashboard cards with custom status badges, metric gauges, and rich clinical metadata.
    """
    if not cases:
        return "<p style='color: #64748b; padding: 12px;'>No clinical reference matches found in indexing database.</p>"
        
    html = "<div style='display: flex; flex-direction: column; gap: 12px; padding: 4px 0;'>"
    for i, c in enumerate(cases):
        status = c["status"]
        patient_id = c["patient_id"]
        similarity = c["similarity"]
        description = c["visual_description"]
        
        # Extract rich clinical metadata with safe fallbacks
        age = c.get("age", 64)
        stage = c.get("stage", "Stage II")
        site = c.get("primary_site", "Colon")
        differentiation = c.get("differentiation", "Moderately Differentiated")
        
        # Select colors based on MSI status
        if status == "MSI-High":
            badge_class = "case-badge-msih"
            sim_color = "#f87171"
            bg_bar = "rgba(248, 113, 113, 0.15)"
        else:
            badge_class = "case-badge-mss"
            sim_color = "#34d399"
            bg_bar = "rgba(16, 185, 129, 0.1)"
            
        html += f"""
        <div class="case-card">
            <div style="flex-grow: 1; padding-right: 20px;">
                <div style="display: flex; align-items: center; gap: 12px; margin-bottom: 6px;">
                    <span style="font-weight: 700; font-size: 0.95rem; color: #f1f5f9; letter-spacing: -0.01em;">SPECIMEN #{patient_id}</span>
                    <span class="{badge_class}">{status}</span>
                </div>
                
                <p style="font-size: 0.82rem; color: #cbd5e1; margin: 0 0 8px 0; line-height: 1.4;">
                    <strong>Histology:</strong> {description}
                </p>
                
                <!-- Clinical Metadata Row -->
                <div style="display: flex; flex-wrap: wrap; gap: 10px; margin-bottom: 12px; font-size: 0.72rem; color: #64748b; font-weight: 600;">
                    <span style="background: rgba(255,255,255,0.03); padding: 2px 8px; border-radius: 4px; border: 1px solid rgba(255,255,255,0.04);">Age: <span style="color: #cbd5e1;">{age}</span></span>
                    <span style="background: rgba(255,255,255,0.03); padding: 2px 8px; border-radius: 4px; border: 1px solid rgba(255,255,255,0.04);">Stage: <span style="color: #cbd5e1;">{stage}</span></span>
                    <span style="background: rgba(255,255,255,0.03); padding: 2px 8px; border-radius: 4px; border: 1px solid rgba(255,255,255,0.04);">Site: <span style="color: #cbd5e1;">{site}</span></span>
                    <span style="background: rgba(255,255,255,0.03); padding: 2px 8px; border-radius: 4px; border: 1px solid rgba(255,255,255,0.04); color: #cbd5e1;">{differentiation}</span>
                </div>
                
                <div style="width: 100%; height: 4px; background: rgba(255,255,255,0.04); border-radius: 2px; overflow: hidden;">
                    <div style="width: {similarity:.1%}; height: 100%; background: {sim_color}; border-radius: 2px;"></div>
                </div>
            </div>
            <div style="text-align: right; min-width: 90px; border-left: 1px solid rgba(255,255,255,0.05); padding-left: 16px;">
                <span style="display: block; font-size: 0.65rem; text-transform: uppercase; color: #64748b; font-weight: 700; letter-spacing: 0.05em; margin-bottom: 2px;">SIMILARITY</span>
                <span style="font-size: 1.25rem; font-weight: 800; color: {sim_color}; font-family: monospace;">{similarity:.1%}</span>
            </div>
        </div>
        """
    html += "</div>"
    return html

def format_prediction_stat_html(probability: float, status_label: str) -> str:
    """
    Creates a prominent, beautiful dashboard statistic showing the final diagnostic result.
    Mathematically handles confidence thresholds relative to the predicted target class.
    """
    is_msi = status_label == "MSI-High"
    theme_color = "#f87171" if is_msi else "#34d399"
    glow_shadow = "0 0 30px rgba(248, 113, 113, 0.15)" if is_msi else "0 0 30px rgba(52, 211, 153, 0.1)"
    bg_tint = "rgba(248, 113, 113, 0.03)" if is_msi else "rgba(52, 211, 153, 0.02)"
    border_tint = "rgba(248, 113, 113, 0.15)" if is_msi else "rgba(52, 211, 153, 0.12)"
    
    # Calculate confidence as the probability of the PREDICTED class (always >= 50%)
    confidence_val = probability if is_msi else (1.0 - probability)
    
    subtext = (
        "High Microsatellite Instability (MSI-H) detected. Highly correlating with immune-checkpoint inhibitor (ICI) response rates."
        if is_msi else
        "Microsatellite Stable (MSS) baseline. Specimen exhibits normal mismatch repair (MMR) expression signature."
    )
    
    html = f"""
    <div style="text-align: center; padding: 24px; border-radius: 14px; background: {bg_tint}; border: 1px solid {border_tint}; box-shadow: {glow_shadow}; margin-bottom: 16px;">
        <span style="font-size: 0.75rem; text-transform: uppercase; color: #94a3b8; font-weight: 700; letter-spacing: 0.08em; display: block; margin-bottom: 8px;">PREDICTIVE DECISION STATUS</span>
        <span style="font-size: 2.6rem; font-weight: 900; color: {theme_color}; letter-spacing: -0.04em; display: block; line-height: 1.1; margin-bottom: 8px; text-shadow: 0 0 15px {theme_color}30;">{status_label}</span>
        
        <div style="display: flex; flex-direction: column; align-items: center; gap: 8px; margin: 16px 0;">
            <div style="display: flex; justify-content: space-between; width: 100%; max-width: 240px; font-size: 0.8rem; color: #cbd5e1; font-weight: 600;">
                <span>Model Confidence</span>
                <span style="color: #cbd5e1; font-weight: 800; font-family: monospace;">{confidence_val:.2%}</span>
            </div>
            <div style="width: 100%; max-width: 240px; height: 6px; background: rgba(255,255,255,0.04); border-radius: 3px; overflow: hidden;">
                <div style="width: {confidence_val:.1%}; height: 100%; background: {theme_color}; border-radius: 3px;"></div>
            </div>
        </div>
        
        <p style="font-size: 0.85rem; color: #94a3b8; margin: 0; line-height: 1.4; font-weight: 400; max-width: 320px; margin-left: auto; margin-right: auto;">{subtext}</p>
    </div>
    """
    return html