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"""Judge handler for evidence assessment using PydanticAI."""
import asyncio
import json
from typing import Any, ClassVar
import structlog
from huggingface_hub import InferenceClient
from pydantic_ai import Agent
from pydantic_ai.models.anthropic import AnthropicModel
from pydantic_ai.models.huggingface import HuggingFaceModel
from pydantic_ai.models.openai import OpenAIModel
from pydantic_ai.providers.anthropic import AnthropicProvider
from pydantic_ai.providers.huggingface import HuggingFaceProvider
from pydantic_ai.providers.openai import OpenAIProvider
from tenacity import retry, retry_if_exception_type, stop_after_attempt, wait_exponential
from src.prompts.judge import (
SYSTEM_PROMPT,
format_empty_evidence_prompt,
format_user_prompt,
)
from src.utils.config import settings
from src.utils.models import AssessmentDetails, Evidence, JudgeAssessment
logger = structlog.get_logger()
def get_model() -> Any:
"""Get the LLM model based on configuration.
Explicitly passes API keys from settings to avoid requiring
users to export environment variables manually.
"""
llm_provider = settings.llm_provider
if llm_provider == "anthropic":
provider = AnthropicProvider(api_key=settings.anthropic_api_key)
return AnthropicModel(settings.anthropic_model, provider=provider)
if llm_provider == "huggingface":
# Free tier - uses HF_TOKEN from environment if available
model_name = settings.huggingface_model or "meta-llama/Llama-3.1-70B-Instruct"
hf_provider = HuggingFaceProvider(api_key=settings.hf_token)
return HuggingFaceModel(model_name, provider=hf_provider)
if llm_provider != "openai":
logger.warning("Unknown LLM provider, defaulting to OpenAI", provider=llm_provider)
openai_provider = OpenAIProvider(api_key=settings.openai_api_key)
return OpenAIModel(settings.openai_model, provider=openai_provider)
class JudgeHandler:
"""
Handles evidence assessment using an LLM with structured output.
Uses PydanticAI to ensure responses match the JudgeAssessment schema.
"""
def __init__(self, model: Any = None) -> None:
"""
Initialize the JudgeHandler.
Args:
model: Optional PydanticAI model. If None, uses config default.
"""
self.model = model or get_model()
self.agent = Agent(
model=self.model,
output_type=JudgeAssessment,
system_prompt=SYSTEM_PROMPT,
retries=3,
)
async def assess(
self,
question: str,
evidence: list[Evidence],
) -> JudgeAssessment:
"""
Assess evidence and determine if it's sufficient.
Args:
question: The user's research question
evidence: List of Evidence objects from search
Returns:
JudgeAssessment with evaluation results
Raises:
JudgeError: If assessment fails after retries
"""
logger.info(
"Starting evidence assessment",
question=question[:100],
evidence_count=len(evidence),
)
# Format the prompt based on whether we have evidence
if evidence:
user_prompt = format_user_prompt(question, evidence)
else:
user_prompt = format_empty_evidence_prompt(question)
try:
# Run the agent with structured output
result = await self.agent.run(user_prompt)
assessment = result.output
logger.info(
"Assessment complete",
sufficient=assessment.sufficient,
recommendation=assessment.recommendation,
confidence=assessment.confidence,
)
return assessment
except Exception as e:
logger.error("Assessment failed", error=str(e))
# Return a safe default assessment on failure
return self._create_fallback_assessment(question, str(e))
def _create_fallback_assessment(
self,
question: str,
error: str,
) -> JudgeAssessment:
"""
Create a fallback assessment when LLM fails.
Args:
question: The original question
error: The error message
Returns:
Safe fallback JudgeAssessment
"""
return JudgeAssessment(
details=AssessmentDetails(
mechanism_score=0,
mechanism_reasoning="Assessment failed due to LLM error",
clinical_evidence_score=0,
clinical_reasoning="Assessment failed due to LLM error",
drug_candidates=[],
key_findings=[],
),
sufficient=False,
confidence=0.0,
recommendation="continue",
next_search_queries=[
f"{question} mechanism",
f"{question} clinical trials",
f"{question} drug candidates",
],
reasoning=f"Assessment failed: {error}. Recommend retrying with refined queries.",
)
class HFInferenceJudgeHandler:
"""
JudgeHandler using HuggingFace Inference API for FREE LLM calls.
Defaults to Llama-3.1-8B-Instruct (requires HF_TOKEN) or falls back to public models.
"""
FALLBACK_MODELS: ClassVar[list[str]] = [
"meta-llama/Llama-3.1-8B-Instruct", # Primary (Gated)
"mistralai/Mistral-7B-Instruct-v0.3", # Secondary
"HuggingFaceH4/zephyr-7b-beta", # Fallback (Ungated)
]
def __init__(self, model_id: str | None = None) -> None:
"""
Initialize with HF Inference client.
Args:
model_id: Optional specific model ID. If None, uses FALLBACK_MODELS chain.
"""
self.model_id = model_id
# Will automatically use HF_TOKEN from env if available
self.client = InferenceClient()
self.call_count = 0
self.last_question: str | None = None
self.last_evidence: list[Evidence] | None = None
async def assess(
self,
question: str,
evidence: list[Evidence],
) -> JudgeAssessment:
"""
Assess evidence using HuggingFace Inference API.
Attempts models in order until one succeeds.
"""
self.call_count += 1
self.last_question = question
self.last_evidence = evidence
# Format the user prompt
if evidence:
user_prompt = format_user_prompt(question, evidence)
else:
user_prompt = format_empty_evidence_prompt(question)
models_to_try: list[str] = [self.model_id] if self.model_id else self.FALLBACK_MODELS
last_error: Exception | None = None
for model in models_to_try:
try:
return await self._call_with_retry(model, user_prompt, question)
except Exception as e:
logger.warning("Model failed", model=model, error=str(e))
last_error = e
continue
# All models failed
logger.error("All HF models failed", error=str(last_error))
return self._create_fallback_assessment(question, str(last_error))
@retry(
stop=stop_after_attempt(3),
wait=wait_exponential(multiplier=1, min=1, max=4),
retry=retry_if_exception_type(Exception),
reraise=True,
)
async def _call_with_retry(self, model: str, prompt: str, question: str) -> JudgeAssessment:
"""Make API call with retry logic using chat_completion."""
loop = asyncio.get_running_loop()
# Build messages for chat_completion (model-agnostic)
messages = [
{
"role": "system",
"content": f"""{SYSTEM_PROMPT}
IMPORTANT: Respond with ONLY valid JSON matching this schema:
{{
"details": {{
"mechanism_score": <int 0-10>,
"mechanism_reasoning": "<string>",
"clinical_evidence_score": <int 0-10>,
"clinical_reasoning": "<string>",
"drug_candidates": ["<string>", ...],
"key_findings": ["<string>", ...]
}},
"sufficient": <bool>,
"confidence": <float 0-1>,
"recommendation": "continue" | "synthesize",
"next_search_queries": ["<string>", ...],
"reasoning": "<string>"
}}""",
},
{"role": "user", "content": prompt},
]
# Use chat_completion (conversational task - supported by all models)
response = await loop.run_in_executor(
None,
lambda: self.client.chat_completion(
messages=messages,
model=model,
max_tokens=1024,
temperature=0.1,
),
)
# Extract content from response
content = response.choices[0].message.content
if not content:
raise ValueError("Empty response from model")
# Extract and parse JSON
json_data = self._extract_json(content)
if not json_data:
raise ValueError("No valid JSON found in response")
return JudgeAssessment(**json_data)
def _extract_json(self, text: str) -> dict[str, Any] | None:
"""
Robust JSON extraction that handles markdown blocks and nested braces.
"""
text = text.strip()
# Remove markdown code blocks if present (with bounds checking)
if "```json" in text:
parts = text.split("```json", 1)
if len(parts) > 1:
inner_parts = parts[1].split("```", 1)
text = inner_parts[0]
elif "```" in text:
parts = text.split("```", 1)
if len(parts) > 1:
inner_parts = parts[1].split("```", 1)
text = inner_parts[0]
text = text.strip()
# Find first '{'
start_idx = text.find("{")
if start_idx == -1:
return None
# Stack-based parsing ignoring chars in strings
count = 0
in_string = False
escape = False
for i, char in enumerate(text[start_idx:], start=start_idx):
if in_string:
if escape:
escape = False
elif char == "\\":
escape = True
elif char == '"':
in_string = False
elif char == '"':
in_string = True
elif char == "{":
count += 1
elif char == "}":
count -= 1
if count == 0:
try:
result = json.loads(text[start_idx : i + 1])
if isinstance(result, dict):
return result
return None
except json.JSONDecodeError:
return None
return None
def _create_fallback_assessment(
self,
question: str,
error: str,
) -> JudgeAssessment:
"""Create a fallback assessment when inference fails."""
return JudgeAssessment(
details=AssessmentDetails(
mechanism_score=0,
mechanism_reasoning=f"Assessment failed: {error}",
clinical_evidence_score=0,
clinical_reasoning=f"Assessment failed: {error}",
drug_candidates=[],
key_findings=[],
),
sufficient=False,
confidence=0.0,
recommendation="continue",
next_search_queries=[
f"{question} mechanism",
f"{question} clinical trials",
f"{question} drug candidates",
],
reasoning=f"HF Inference failed: {error}. Recommend configuring OpenAI/Anthropic key.",
)
class MockJudgeHandler:
"""
Mock JudgeHandler for demo mode without LLM calls.
Extracts meaningful information from real search results
to provide a useful demo experience without requiring API keys.
"""
def __init__(self, mock_response: JudgeAssessment | None = None) -> None:
"""
Initialize with optional mock response.
Args:
mock_response: The assessment to return. If None, extracts from evidence.
"""
self.mock_response = mock_response
self.call_count = 0
self.last_question: str | None = None
self.last_evidence: list[Evidence] | None = None
def _extract_key_findings(self, evidence: list[Evidence], max_findings: int = 5) -> list[str]:
"""Extract key findings from evidence titles."""
findings = []
for e in evidence[:max_findings]:
# Use first 150 chars of title as a finding
title = e.citation.title
if len(title) > 150:
title = title[:147] + "..."
findings.append(title)
return findings if findings else ["No specific findings extracted (demo mode)"]
def _extract_drug_candidates(self, question: str, evidence: list[Evidence]) -> list[str]:
"""Extract drug candidates - demo mode returns honest message."""
# Don't attempt heuristic extraction - it produces garbage like "Oral", "Kidney"
# Real drug extraction requires LLM analysis
return [
"Drug identification requires AI analysis",
"Enter API key above for full results",
]
async def assess(
self,
question: str,
evidence: list[Evidence],
) -> JudgeAssessment:
"""Return assessment based on actual evidence (demo mode)."""
self.call_count += 1
self.last_question = question
self.last_evidence = evidence
if self.mock_response:
return self.mock_response
min_evidence = 3
evidence_count = len(evidence)
# Extract meaningful data from actual evidence
drug_candidates = self._extract_drug_candidates(question, evidence)
key_findings = self._extract_key_findings(evidence)
# Calculate scores based on evidence quantity
mechanism_score = min(10, evidence_count * 2) if evidence_count > 0 else 0
clinical_score = min(10, evidence_count) if evidence_count > 0 else 0
return JudgeAssessment(
details=AssessmentDetails(
mechanism_score=mechanism_score,
mechanism_reasoning=(
f"Demo mode: Found {evidence_count} sources. "
"Configure LLM API key for detailed mechanism analysis."
),
clinical_evidence_score=clinical_score,
clinical_reasoning=(
f"Demo mode: {evidence_count} sources retrieved from PubMed, "
"ClinicalTrials.gov, and Europe PMC. Full analysis requires LLM API key."
),
drug_candidates=drug_candidates,
key_findings=key_findings,
),
sufficient=evidence_count >= min_evidence,
confidence=min(0.5, evidence_count * 0.1) if evidence_count > 0 else 0.0,
recommendation="synthesize" if evidence_count >= min_evidence else "continue",
next_search_queries=(
[f"{question} mechanism", f"{question} clinical trials"]
if evidence_count < min_evidence
else []
),
reasoning=(
f"Demo mode assessment based on {evidence_count} real search results. "
"For AI-powered analysis with drug candidate identification and "
"evidence synthesis, configure OPENAI_API_KEY or ANTHROPIC_API_KEY."
),
)
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