Highlight mutated codons in red on generated variant DNA

DE tool now returns real DNA; fix sequence-block stacking; add copy/download

Turing can now fetch a sequence by gene name or accession — new fetch_sequence tool

Wire cross-user field priors into Turing's chat tools (were REST-only)

Turing: collapse long sequences in chat, add context-window meter

Turing: retroactive seed cleanup + auto-recover expired sessions

Turing: wire ESM-2, fix auth header, friendly credits message, tool cards

Turing: go live + wire tool-calling

SECURITY: fix live API key leak in agent error responses

Add native Python Turing agent orchestrator (OpenRouter + Gemini 3.5 Flash)

Add pairwise sequence alignment (Needleman–Wunsch / Smith–Waterman)

Plasmid: richer common-features auto-annotation (SnapGene-style)

Security hardening: RLS-as-user, rate limiting, headers, PII + endpoint cleanup

feat: richer DE aggregate — substitution × ESM ΔLL bin (opt-in, gated)

feat: primer + cloning capture loops on the unified framework

feat: wire the CRISPR on-target prior into scoring (data-out, guarded)

feat: CRISPR learning loop on the unified framework (capture editing efficiency)

feat: unified outcomes framework — tool-agnostic capture + aggregate + calibrate

feat: primer/PCR versatility — design, multiplex, local specificity (backend)

feat: cross-user aggregate prior (the data moat) — built, run gated to 2026-07-07

test: cover DE active-learning surrogate (Design→Build→Test→Learn)

Unified "My designs" hub: save every tool, not just CRISPR

Fix reported production bugs: stuck dropdowns, blocked SNP, session loop

Adversarial audit of Plasmid Studio: fix XSS, DoS, and input-validation gaps

Plasmid Studio M3 + M4: sequence editor + cloning simulation

Plasmid Studio (M1+M2): import/annotate/map + restriction/digest + library

Primer Picker: add strict 3'-end matching knob for the specificity scan

Primer Picker: separate intended product from off-targets; collapse redundant hits

Primer Picker: full in-silico PCR specificity — no more "go to NCBI Primer-BLAST"

Add Primer Picker: batch-analyse primers, rank, recommend the best

Fix: Identify/AlphaFold dead-ends on heavily-sequenced proteins (e.g. Cas9)

IP Radar patents (env-gated) + Toxicity & Synthesis Oracle (Red Team)

Live Collision IP Radar v1 — opt-in literature scan (Europe PMC)

Fix AlphaFold viewer showing nothing (stale model version + silent 404)

CRISPR M5: structure viewer — cut site on the AlphaFold model

CRISPR M2: paste-anything input + fix phantom progress bar

CRISPR M1: base-editing design mode (CBE/ABE + iSTOP + AA consequence)

CRISPR M0: validation test suite + fix KO cut-position copy-paste bug