variant,pocket_id,pocket_name,volume_wt,volume_mut,volume_delta,druggability,mutant_created,hydrophobicity,polarity,docking_gate
p.R110C,p.R110C-P1,Mutation-site / created cavity,165.0,175.2,10.2,0.508,False,0.45,0.55,Hold — evaluate pocket before docking
p.R110C,p.R110C-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.R110C,p.R110C-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.Q144L,p.Q144L-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.Q144L,p.Q144L-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.Q144L,p.Q144L-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.K132N,p.K132N-P1,Mutation-site / created cavity,48.0,194.4,146.4,0.676,True,0.62,0.38,Open
p.K132N,p.K132N-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.K132N,p.K132N-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.P152L,p.P152L-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.P152L,p.P152L-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.P152L,p.P152L-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.R175L,p.R175L-P1,Mutation-site / created cavity,165.0,168.9,3.9,0.531,False,0.62,0.38,Hold — evaluate pocket before docking
p.R175L,p.R175L-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.R175L,p.R175L-P3,Zn-site adjacent,120.0,125.0,5.0,0.344,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.V172F,p.V172F-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.516,False,0.62,0.38,Hold — evaluate pocket before docking
p.V172F,p.V172F-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.V172F,p.V172F-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.G154C,p.G154C-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.G154C,p.G154C-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.G154C,p.G154C-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.Y220C,p.Y220C-P1,Mutation-site / created cavity,48.0,248.0,200.0,0.886,True,0.78,0.22,Open
p.Y220C,p.Y220C-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.Y220C,p.Y220C-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.Q192*,p.Q192*-P1,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Closed — not a missense protein product
p.E204*,p.E204*-P1,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Closed — not a missense protein product
p.R213Q,p.R213Q-P1,Mutation-site / created cavity,165.0,169.6,4.6,0.483,False,0.45,0.55,Hold — evaluate pocket before docking
p.R213Q,p.R213Q-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.R213Q,p.R213Q-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.Y220S,p.Y220S-P1,Mutation-site / created cavity,48.0,208.0,160.0,0.829,True,0.78,0.22,Open
p.Y220S,p.Y220S-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.Y220S,p.Y220S-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.L252P,p.L252P-P1,Mutation-site / created cavity,48.0,196.2,148.2,0.688,True,0.62,0.38,Open
p.L252P,p.L252P-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.L252P,p.L252P-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.R249S,p.R249S-P1,Mutation-site / created cavity,165.0,178.3,13.3,0.524,False,0.45,0.55,Hold — evaluate pocket before docking
p.R249S,p.R249S-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.R249S,p.R249S-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.G244D,p.G244D-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.G244D,p.G244D-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.G244D,p.G244D-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.G245C,p.G245C-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.G245C,p.G245C-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.G245C,p.G245C-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.D281E,p.D281E-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.D281E,p.D281E-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.D281E,p.D281E-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.D281H,p.D281H-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.D281H,p.D281H-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.D281H,p.D281H-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.P278S,p.P278S-P1,Mutation-site / created cavity,165.0,168.7,3.7,0.479,False,0.45,0.55,Hold — evaluate pocket before docking
p.P278S,p.P278S-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.P278S,p.P278S-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.R282W,p.R282W-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.R282W,p.R282W-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.R282W,p.R282W-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.V274F,p.V274F-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.V274F,p.V274F-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.V274F,p.V274F-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.R273C,p.R273C-P1,Mutation-site / created cavity,165.0,167.6,2.6,0.424,False,0.28,0.72,Hold — DNA-contact; do not assume a rescue cavity
p.R273C,p.R273C-P2,DNA-contact cleft,210.0,210.0,0.0,0.514,False,0.3,0.7,Hold — DNA-contact; do not assume a rescue cavity
p.R273C,p.R273C-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Hold — DNA-contact; do not assume a rescue cavity
p.E286A,p.E286A-P1,Mutation-site / created cavity,165.0,172.8,7.8,0.497,False,0.45,0.55,Hold — evaluate pocket before docking
p.E286A,p.E286A-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.E286A,p.E286A-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.E285K,p.E285K-P1,Mutation-site / created cavity,165.0,165.0,0.0,0.465,False,0.45,0.55,Hold — evaluate pocket before docking
p.E285K,p.E285K-P2,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Hold — evaluate pocket before docking
p.E285K,p.E285K-P3,Zn-site adjacent,120.0,125.0,5.0,0.341,False,0.4,0.6,Closed — no tractable small-molecule hypothesis
p.X307,p.X307-P1,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Closed — not a missense protein product
p.X126,p.X126-P1,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Closed — not a missense protein product
p.X125,p.X125-P1,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Closed — not a missense protein product
p.X261,p.X261-P1,DNA-contact cleft,210.0,200.0,-10.0,0.497,False,0.3,0.7,Closed — not a missense protein product