variant,compound_id,name,status,dock_mut,dock_wt,mutant_preference,Bmut,Sselectivity,MDstability,Frescue,ADMET,Evidence,Risk,rescue_score,confidence,key_contacts,pose_qc,y220c_control,lipinski_pass,mw,logp,route,functional_class,admet_flag,applicability,mechanism,scoring_version,reason_codes,recommendation,next_experiment,kd_pred_M,rank
p.D281E,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.86,"C281,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.D281E,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.86,"C281,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.D281E,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.D281E,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.D281E,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.D281E,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.D281E,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.D281E,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.D281E,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.D281E,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.876,"C281,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.D281E,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.D281E,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.D281E,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.D281E,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.D281E,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.D281E,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.D281E,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.D281E,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.D281E,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.D281E,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.D281E,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.D281E,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.D281E,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.D281E,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.D281E,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.86,"C281,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.D281E,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.D281E,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.D281E,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.D281E,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.D281E,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.D281E,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.D281E,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.D281E,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.D281E,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.D281E,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.D281E,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.D281E,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.D281E,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.D281E,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.D281E,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.D281E,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.D281E,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.D281E,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.D281E,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.D281E,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.D281E,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.D281E,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.D281E,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.D281E,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.D281E,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.D281E,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.D281E,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.D281E,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.D281E,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.D281E,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.D281E,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.D281E,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.D281E,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.D281E,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.D281E,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.D281E,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.D281E,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.D281E,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.D281E,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.D281E,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.D281E,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.D281E,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.D281E,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.D281E,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.D281E,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.D281E,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.D281E,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.D281E,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.D281E,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.D281E,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.D281E,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.D281E,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.D281E,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.D281E,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.D281E,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.D281E,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.D281E,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.D281E,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.D281E,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.D281E,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.D281E,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.D281E,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.D281E,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.D281E,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.D281E,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.D281E,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.D281E,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.D281E,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.D281E,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.D281E,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.D281E,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.D281E,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.D281E,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.D281E,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.D281E,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.D281E,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.D281E,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.D281E,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.D281E,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.D281E,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.D281E,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.D281E,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.D281E,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.D281E,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.D281E,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.D281E,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,429.0,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.D281E,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.D281E,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.D281E,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.D281E,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.D281E,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.D281E,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.D281E,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.D281E,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.D281E,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.D281E,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.D281E,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.D281E,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.D281E,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.D281E,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.D281E,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.D281E,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.D281E,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.D281E,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.D281E,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.D281E,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.D281E,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.D281E,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.D281E,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.D281E,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.D281E,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.D281E,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.D281E,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.D281E,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.D281E,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.D281E,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.D281E,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.D281E,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.D281E,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.D281E,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.D281E,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.D281E,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.D281E,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.D281E,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.D281E,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.D281E,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.D281E,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.D281E,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.D281E,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.D281E,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.D281E,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.D281E,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.D281E,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.D281E,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.D281E,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.D281E,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.D281E,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.D281E,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.D281E,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.D281E,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.D281E,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.D281E,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.D281E,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.D281E,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.D281E,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.D281E,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.D281E,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.D281E,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.D281E,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.D281E,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.D281E,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.D281E,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.D281E,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.D281E,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.D281E,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.D281E,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.D281E,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.D281E,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.D281E,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.D281E,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,552.3,4.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.D281E,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.D281E,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.D281E,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.D281E,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.D281E,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.D281E,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.D281E,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.D281E,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.D281E,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.D281E,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.D281E,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.D281E,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.D281E,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.D281E,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.D281E,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.D281E,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.D281E,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.D281E,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.D281E,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.0,2.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.D281E,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.D281E,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.D281E,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.D281E,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.D281E,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.D281E,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.D281E,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.D281E,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.D281E,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.D281E,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.D281E,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.D281E,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.D281E,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.D281E,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.D281E,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.D281E,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.636,"C281,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.D281H,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.86,"C281,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.D281H,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.86,"C281,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.D281H,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.D281H,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.D281H,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.D281H,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.D281H,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.D281H,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.D281H,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.D281H,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.876,"C281,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.D281H,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.D281H,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.D281H,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.D281H,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.D281H,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.D281H,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.D281H,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.D281H,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.D281H,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.D281H,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.D281H,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.D281H,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.D281H,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.D281H,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.D281H,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.86,"C281,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.D281H,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.D281H,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.D281H,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.D281H,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.D281H,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.D281H,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.D281H,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.D281H,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.D281H,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.D281H,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.D281H,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.D281H,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.D281H,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.D281H,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.D281H,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.D281H,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.D281H,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.D281H,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.D281H,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.D281H,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.D281H,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.D281H,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.D281H,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.D281H,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.D281H,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.D281H,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.D281H,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.D281H,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.D281H,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.D281H,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.D281H,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.D281H,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.D281H,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.D281H,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.D281H,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.D281H,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.D281H,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.D281H,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.D281H,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.D281H,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.D281H,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.D281H,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.D281H,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.D281H,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.D281H,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.D281H,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.D281H,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.D281H,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.D281H,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.D281H,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.D281H,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.D281H,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.D281H,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.D281H,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.D281H,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.D281H,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.D281H,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.D281H,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.D281H,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.D281H,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.D281H,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.D281H,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.D281H,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.D281H,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.D281H,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.D281H,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.824,"C281,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.D281H,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.D281H,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.D281H,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.D281H,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.D281H,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.D281H,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.D281H,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.D281H,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.D281H,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.D281H,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.D281H,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.D281H,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.D281H,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.D281H,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.D281H,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.D281H,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.D281H,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.D281H,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.D281H,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.D281H,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,429.0,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.D281H,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.D281H,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.D281H,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.D281H,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.D281H,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.D281H,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.D281H,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.D281H,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.D281H,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.D281H,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.D281H,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.D281H,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.D281H,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.D281H,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.D281H,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.D281H,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.D281H,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.D281H,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.D281H,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.D281H,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.D281H,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.D281H,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.D281H,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.D281H,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.D281H,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.D281H,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.D281H,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.D281H,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.D281H,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.D281H,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.D281H,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.D281H,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.D281H,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.D281H,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.D281H,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.D281H,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.D281H,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.D281H,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.D281H,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.D281H,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.D281H,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.D281H,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.D281H,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.D281H,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.78,"C281,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.D281H,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.D281H,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.D281H,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.D281H,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.D281H,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.D281H,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.D281H,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.D281H,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.D281H,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.D281H,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.D281H,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.D281H,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.D281H,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.D281H,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.D281H,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.D281H,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.D281H,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.D281H,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.D281H,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.D281H,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.D281H,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.D281H,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.D281H,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.D281H,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.D281H,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.D281H,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.D281H,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.D281H,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.D281H,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.D281H,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,552.3,4.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.D281H,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.D281H,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.D281H,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.D281H,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.D281H,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.D281H,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.D281H,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.D281H,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.D281H,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.D281H,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.D281H,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.D281H,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.D281H,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.D281H,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.D281H,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.D281H,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.D281H,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.D281H,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.D281H,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,404.0,2.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.D281H,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.D281H,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.D281H,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.D281H,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.D281H,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.D281H,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.D281H,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.D281H,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.D281H,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.D281H,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.D281H,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.D281H,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.D281H,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.D281H,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.D281H,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.736,"C281,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.D281H,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.636,"C281,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.E285K,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.86,"C285,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.E285K,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.86,"C285,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.E285K,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.E285K,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.E285K,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.E285K,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.E285K,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.E285K,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.E285K,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.E285K,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.876,"C285,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.E285K,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.E285K,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.E285K,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.E285K,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.E285K,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.E285K,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.E285K,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.E285K,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.E285K,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.E285K,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.E285K,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.E285K,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.E285K,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.E285K,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.E285K,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.86,"C285,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.E285K,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.E285K,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.E285K,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.E285K,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.E285K,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.E285K,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.E285K,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.E285K,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.E285K,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.E285K,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.E285K,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.E285K,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.E285K,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.E285K,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.E285K,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.E285K,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.E285K,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.E285K,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.E285K,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.E285K,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.E285K,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.E285K,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.E285K,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.E285K,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.E285K,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.E285K,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.E285K,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.E285K,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.E285K,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.E285K,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.E285K,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.E285K,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.E285K,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.E285K,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.E285K,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.E285K,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.E285K,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.E285K,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.E285K,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.E285K,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.E285K,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.E285K,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.E285K,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.E285K,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.E285K,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.E285K,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.E285K,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.E285K,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.E285K,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.E285K,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.E285K,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.E285K,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.E285K,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.E285K,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.E285K,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.E285K,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.E285K,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.E285K,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.E285K,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.E285K,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.E285K,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.E285K,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.E285K,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.E285K,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.E285K,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.E285K,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.824,"C285,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.E285K,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.E285K,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.E285K,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.E285K,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.E285K,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.E285K,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.E285K,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.E285K,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.E285K,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.E285K,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.E285K,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.E285K,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.E285K,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.E285K,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.E285K,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.E285K,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.E285K,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.E285K,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.E285K,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.E285K,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,429.0,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.E285K,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.E285K,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.E285K,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.E285K,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.E285K,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.E285K,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.E285K,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.E285K,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.E285K,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.E285K,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.E285K,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.E285K,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.E285K,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.E285K,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.E285K,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.E285K,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.E285K,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.E285K,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.E285K,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.E285K,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.E285K,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.E285K,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.E285K,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.E285K,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.E285K,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.E285K,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.E285K,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.E285K,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.E285K,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.E285K,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.E285K,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.E285K,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.E285K,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.E285K,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.E285K,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.E285K,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.E285K,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.E285K,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.E285K,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.E285K,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.E285K,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.E285K,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.E285K,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.E285K,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.78,"C285,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.E285K,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.E285K,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.E285K,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.E285K,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.E285K,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.E285K,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.E285K,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.E285K,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.E285K,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.E285K,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.E285K,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.E285K,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.E285K,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.E285K,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.E285K,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.E285K,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.E285K,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.E285K,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.E285K,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.E285K,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.E285K,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.E285K,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.E285K,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.E285K,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.E285K,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.E285K,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.E285K,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.E285K,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.E285K,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.E285K,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,552.3,4.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.E285K,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.E285K,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,404.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.E285K,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.E285K,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.E285K,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.E285K,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.E285K,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.E285K,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.E285K,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.E285K,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.E285K,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.E285K,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.E285K,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.E285K,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.E285K,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.E285K,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.E285K,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.E285K,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.E285K,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,404.0,2.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.E285K,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.E285K,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.E285K,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.E285K,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.E285K,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.E285K,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.E285K,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.E285K,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.E285K,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.E285K,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.E285K,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.E285K,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.E285K,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.E285K,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.E285K,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.736,"C285,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.E285K,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.636,"C285,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.E286A,CTRL-001,PK083,preclinical,-4.51,-3.31,0.4,0.064,0.4,0.345,0.31,0.645,0.8,0.363,0.313,0.86,"C286,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000491,1
p.E286A,WM-TP53-00860,WM-TP53-00860,preclinical,-4.27,-3.26,0.337,0.034,0.337,0.319,0.2,0.719,0.4,0.292,0.25,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,2
p.E286A,CTRL-003,PK11000,preclinical,-3.35,-3.2,0.05,0.0,0.05,0.258,0.186,0.854,0.8,0.171,0.245,0.86,"C286,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,3
p.E286A,WM-TP53-05841,WM-TP53-05841,clinical,-3.92,-3.2,0.24,0.0,0.24,0.286,0.159,0.731,0.62,0.249,0.241,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001331,4
p.E286A,WM-TP53-07201,WM-TP53-07201,screening,-4.59,-3.73,0.287,0.074,0.287,0.334,0.202,0.758,0.18,0.234,0.24,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000429,5
p.E286A,WM-TP53-02322,WM-TP53-02322,preclinical,-4.35,-3.78,0.19,0.044,0.19,0.303,0.163,0.812,0.4,0.176,0.239,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000644,6
p.E286A,WM-TP53-00146,WM-TP53-00146,screening,-4.28,-3.39,0.297,0.035,0.297,0.314,0.189,0.769,0.18,0.273,0.226,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000725,7
p.E286A,WM-TP53-01438,WM-TP53-01438,screening,-4.32,-3.6,0.24,0.04,0.24,0.308,0.175,0.779,0.18,0.212,0.22,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,8
p.E286A,WM-TP53-05637,WM-TP53-05637,screening,-4.04,-3.22,0.273,0.005,0.273,0.294,0.17,0.716,0.18,0.26,0.204,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001087,9
p.E286A,WM-TP53-05280,WM-TP53-05280,screening,-4.33,-3.76,0.19,0.041,0.19,0.301,0.162,0.699,0.18,0.188,0.201,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000666,10
p.E286A,WM-TP53-03410,WM-TP53-03410,screening,-3.84,-3.2,0.213,0.0,0.213,0.282,0.151,0.79,0.18,0.229,0.199,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001524,11
p.E286A,WM-TP53-02764,WM-TP53-02764,screening,-3.81,-3.2,0.203,0.0,0.203,0.28,0.149,0.781,0.18,0.191,0.199,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,12
p.E286A,WM-TP53-01421,WM-TP53-01421,screening,-4.16,-3.2,0.32,0.02,0.32,0.309,0.19,0.561,0.18,0.321,0.198,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000888,13
p.E286A,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.172,0.599,0.88,0.388,0.193,0.876,"C286,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.E286A,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.807,0.62,0.228,0.193,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,15
p.E286A,WM-TP53-01795,WM-TP53-01795,screening,-4.03,-3.25,0.26,0.004,0.26,0.291,0.166,0.61,0.18,0.217,0.191,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001106,16
p.E286A,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.781,0.62,0.256,0.188,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,17
p.E286A,WM-TP53-00707,WM-TP53-00707,screening,-3.68,-3.2,0.16,0.0,0.16,0.274,0.137,0.792,0.18,0.24,0.186,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,18
p.E286A,WM-TP53-07949,WM-TP53-07949,approved,-3.21,-3.2,0.003,0.0,0.003,0.25,0.093,0.651,0.72,0.244,0.184,0.844,"C286,R158,M160,Y163,R273,R249",Pass,False,True,255.6,2.69,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,19
p.E286A,WM-TP53-05586,WM-TP53-05586,screening,-3.93,-3.42,0.17,0.0,0.17,0.276,0.14,0.688,0.18,0.172,0.181,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001309,20
p.E286A,WM-TP53-04600,WM-TP53-04600,screening,-3.59,-3.2,0.13,0.0,0.13,0.27,0.128,0.791,0.18,0.204,0.181,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002325,21
p.E286A,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.709,0.62,0.267,0.179,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,22
p.E286A,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.707,0.62,0.288,0.177,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,23
p.E286A,WM-TP53-06623,WM-TP53-06623,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.135,0.727,0.18,0.242,0.176,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,24
p.E286A,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.708,0.62,0.333,0.173,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.E286A,WM-TP53-06810,WM-TP53-06810,clinical,-3.69,-3.2,0.163,0.0,0.163,0.274,0.137,0.508,0.62,0.543,0.172,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001963,26
p.E286A,WM-TP53-00367,WM-TP53-00367,screening,-3.68,-3.2,0.16,0.0,0.16,0.274,0.137,0.638,0.18,0.228,0.168,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,27
p.E286A,WM-TP53-03546,WM-TP53-03546,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.123,0.757,0.18,0.272,0.167,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,28
p.E286A,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.77,0.4,0.225,0.167,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.E286A,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.172,0.609,0.8,0.653,0.165,0.86,"C286,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.E286A,WM-TP53-06079,WM-TP53-06079,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.116,0.778,0.18,0.257,0.165,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,259.7,2.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.E286A,WM-TP53-04056,WM-TP53-04056,screening,-3.37,-3.2,0.057,0.0,0.057,0.259,0.108,0.798,0.18,0.198,0.165,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,244.9,1.84,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003371,32
p.E286A,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.61,0.62,0.315,0.163,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.E286A,WM-TP53-01217,WM-TP53-01217,screening,-4.44,-3.83,0.203,0.055,0.203,0.311,0.171,0.509,0.18,0.491,0.162,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000553,34
p.E286A,WM-TP53-02798,WM-TP53-02798,screening,-3.41,-3.2,0.07,0.0,0.07,0.261,0.112,0.767,0.18,0.225,0.162,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003151,35
p.E286A,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.754,0.4,0.267,0.162,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,36
p.E286A,WM-TP53-05246,WM-TP53-05246,preclinical,-3.74,-3.22,0.173,0.0,0.173,0.276,0.14,0.507,0.4,0.436,0.161,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,37
p.E286A,WM-TP53-04991,WM-TP53-04991,screening,-3.5,-3.2,0.1,0.0,0.1,0.265,0.12,0.68,0.18,0.202,0.161,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002706,38
p.E286A,WM-TP53-04481,WM-TP53-04481,preclinical,-3.3,-3.2,0.033,0.0,0.033,0.255,0.101,0.711,0.4,0.321,0.161,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,275.4,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003794,39
p.E286A,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.696,0.4,0.189,0.161,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.E286A,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.695,0.4,0.206,0.16,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.E286A,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.694,0.4,0.203,0.16,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.E286A,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.736,0.4,0.272,0.159,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.E286A,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.728,0.4,0.262,0.159,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,44
p.E286A,WM-TP53-02526,WM-TP53-02526,screening,-4.39,-3.8,0.197,0.049,0.197,0.306,0.167,0.505,0.18,0.495,0.158,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000602,45
p.E286A,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.839,0.18,0.178,0.157,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.E286A,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.565,0.62,0.339,0.156,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.E286A,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.627,0.62,0.426,0.156,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.E286A,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.821,0.18,0.182,0.155,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,49
p.E286A,WM-TP53-05331,WM-TP53-05331,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.112,0.688,0.18,0.222,0.153,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,246.1,2.31,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,50
p.E286A,WM-TP53-08000,WM-TP53-08000,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.112,0.688,0.18,0.224,0.153,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,51
p.E286A,WM-TP53-03172,WM-TP53-03172,screening,-3.22,-3.2,0.007,0.0,0.007,0.251,0.094,0.797,0.18,0.189,0.153,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004343,52
p.E286A,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.797,0.18,0.171,0.153,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,53
p.E286A,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.693,0.4,0.292,0.153,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.E286A,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.804,0.18,0.197,0.152,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.E286A,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.785,0.18,0.159,0.152,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.E286A,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.812,0.18,0.209,0.152,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.E286A,WM-TP53-05705,WM-TP53-05705,screening,-3.85,-3.31,0.18,0.0,0.18,0.277,0.142,0.601,0.18,0.452,0.151,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,58
p.E286A,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.579,0.62,0.419,0.151,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.E286A,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.698,0.4,0.315,0.151,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.E286A,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.785,0.18,0.179,0.151,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.E286A,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.651,0.4,0.256,0.151,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,62
p.E286A,WM-TP53-07048,WM-TP53-07048,screening,-3.71,-3.2,0.17,0.0,0.17,0.276,0.14,0.592,0.18,0.433,0.149,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,63
p.E286A,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.754,0.18,0.159,0.149,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.E286A,WM-TP53-06402,WM-TP53-06402,screening,-3.77,-3.32,0.15,0.0,0.15,0.273,0.134,0.615,0.18,0.418,0.148,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,65
p.E286A,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.756,0.18,0.168,0.148,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.E286A,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.767,0.18,0.19,0.148,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,67
p.E286A,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.677,0.4,0.34,0.147,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.E286A,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.591,0.4,0.221,0.146,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.E286A,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.774,0.18,0.219,0.146,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.E286A,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.528,0.62,0.412,0.145,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.E286A,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.776,0.18,0.234,0.145,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.E286A,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.741,0.18,0.188,0.145,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.E286A,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.546,0.62,0.455,0.144,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,74
p.E286A,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.721,0.18,0.178,0.143,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.E286A,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.743,0.18,0.215,0.143,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.E286A,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.75,0.18,0.221,0.143,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.E286A,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.775,0.18,0.264,0.143,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.E286A,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.619,0.4,0.304,0.143,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.E286A,WM-TP53-06555,WM-TP53-06555,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.105,0.719,0.18,0.329,0.142,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,265.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,80
p.E286A,WM-TP53-01625,WM-TP53-01625,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.097,0.694,0.18,0.212,0.142,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,81
p.E286A,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.706,0.18,0.17,0.142,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.E286A,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.633,0.4,0.339,0.142,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.E286A,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.754,0.18,0.248,0.142,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.E286A,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.744,0.18,0.232,0.142,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.E286A,WM-TP53-05365,WM-TP53-05365,screening,-3.4,-3.2,0.067,0.0,0.067,0.26,0.111,0.694,0.18,0.366,0.141,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,269.4,3.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003204,86
p.E286A,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.73,0.18,0.221,0.141,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.E286A,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.734,0.18,0.227,0.141,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.E286A,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.735,0.18,0.231,0.141,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,89
p.E286A,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.744,0.18,0.235,0.141,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.E286A,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.733,0.18,0.231,0.14,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.E286A,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.746,0.18,0.249,0.14,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.E286A,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.764,0.18,0.286,0.14,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.E286A,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.742,0.18,0.267,0.139,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.E286A,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.731,0.18,0.244,0.139,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.E286A,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.737,0.18,0.258,0.139,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.E286A,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.741,0.18,0.256,0.139,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.E286A,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.734,0.18,0.244,0.139,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.E286A,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.494,0.62,0.45,0.138,0.824,"C286,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.E286A,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.686,0.18,0.196,0.138,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.E286A,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.756,0.18,0.292,0.138,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,101
p.E286A,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.716,0.18,0.249,0.137,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.E286A,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.727,0.18,0.268,0.137,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.E286A,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.736,0.18,0.272,0.137,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.E286A,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.724,0.18,0.275,0.136,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.E286A,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.69,0.18,0.223,0.136,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.E286A,WM-TP53-05926,WM-TP53-05926,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.095,0.66,0.18,0.224,0.135,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,246.6,2.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,107
p.E286A,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.712,0.18,0.272,0.135,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.E286A,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.724,0.18,0.288,0.135,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.E286A,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.721,0.18,0.288,0.134,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.E286A,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.598,0.4,0.377,0.134,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.E286A,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.709,0.18,0.289,0.133,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.E286A,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.728,0.18,0.318,0.133,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.E286A,WM-TP53-03988,WM-TP53-03988,screening,-3.59,-3.2,0.13,0.0,0.13,0.27,0.128,0.555,0.18,0.463,0.132,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002325,114
p.E286A,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.705,0.18,0.293,0.132,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.E286A,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.71,0.18,0.299,0.132,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.E286A,WM-TP53-06487,WM-TP53-06487,screening,-3.38,-3.2,0.06,0.0,0.06,0.259,0.109,0.637,0.18,0.382,0.131,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,302.0,4.96,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003314,117
p.E286A,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.706,0.18,0.31,0.131,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.E286A,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.671,0.18,0.253,0.131,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.E286A,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.679,0.18,0.279,0.13,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.E286A,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.704,0.18,0.32,0.13,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.E286A,WM-TP53-05739,WM-TP53-05739,screening,-3.5,-3.2,0.1,0.0,0.1,0.265,0.12,0.575,0.18,0.434,0.129,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002706,122
p.E286A,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.686,0.18,0.307,0.129,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.E286A,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.7,0.18,0.329,0.129,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.E286A,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.679,0.18,0.301,0.128,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.E286A,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.675,0.18,0.301,0.128,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.E286A,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.631,0.18,0.235,0.128,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.E286A,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.686,0.18,0.309,0.128,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.E286A,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.579,0.4,0.424,0.128,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.E286A,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.673,0.18,0.309,0.127,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.E286A,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.683,0.18,0.317,0.127,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.E286A,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.624,0.18,0.236,0.127,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.E286A,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.672,0.18,0.303,0.127,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.E286A,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.666,0.18,0.309,0.126,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.E286A,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.676,0.18,0.322,0.126,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.E286A,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.609,0.18,0.228,0.126,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.E286A,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.658,0.18,0.298,0.126,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.E286A,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.515,0.4,0.356,0.126,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.E286A,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.681,0.18,0.334,0.126,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.E286A,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.537,0.4,0.408,0.125,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.E286A,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.599,0.18,0.233,0.124,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.E286A,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.665,0.18,0.329,0.124,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.E286A,WM-TP53-06028,WM-TP53-06028,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.097,0.644,0.18,0.374,0.123,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,292.0,4.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,143
p.E286A,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.662,0.18,0.343,0.123,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.E286A,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.668,0.18,0.35,0.123,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.E286A,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.657,0.18,0.343,0.122,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.E286A,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.65,0.18,0.349,0.121,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.E286A,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.662,0.18,0.364,0.121,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.E286A,WM-TP53-05093,WM-TP53-05093,screening,-3.47,-3.2,0.09,0.0,0.09,0.264,0.117,0.523,0.18,0.447,0.12,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002847,149
p.E286A,WM-TP53-02730,WM-TP53-02730,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.105,0.572,0.18,0.414,0.118,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,150
p.E286A,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.641,0.18,0.373,0.118,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.E286A,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.601,0.18,0.324,0.117,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.E286A,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.592,0.18,0.317,0.117,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.E286A,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.629,0.18,0.373,0.117,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.E286A,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.624,0.18,0.356,0.117,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.E286A,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.536,0.4,0.506,0.117,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,156
p.E286A,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.631,0.18,0.376,0.117,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.E286A,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.632,0.18,0.366,0.117,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,158
p.E286A,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.581,0.18,0.307,0.116,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.E286A,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.617,0.18,0.374,0.115,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.E286A,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.506,0.4,0.489,0.114,0.78,"C286,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,161
p.E286A,WM-TP53-02492,WM-TP53-02492,screening,-3.33,-3.2,0.043,0.0,0.043,0.256,0.104,0.546,0.18,0.419,0.113,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003607,162
p.E286A,WM-TP53-00299,WM-TP53-00299,screening,-3.31,-3.2,0.037,0.0,0.037,0.256,0.102,0.581,0.18,0.488,0.111,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00373,163
p.E286A,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.6,0.18,0.402,0.111,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.E286A,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.603,0.18,0.403,0.111,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.E286A,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.601,0.18,0.428,0.109,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.E286A,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.587,0.18,0.418,0.108,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.E286A,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.572,0.18,0.409,0.107,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.E286A,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.608,0.18,0.459,0.107,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.E286A,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.568,0.18,0.418,0.106,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.E286A,WM-TP53-01472,WM-TP53-01472,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.105,0.522,0.18,0.496,0.105,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,171
p.E286A,WM-TP53-05671,WM-TP53-05671,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.095,0.577,0.18,0.482,0.105,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,172
p.E286A,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.555,0.18,0.411,0.105,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.E286A,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.558,0.18,0.411,0.105,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.E286A,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.572,0.18,0.436,0.105,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.E286A,WM-TP53-06895,WM-TP53-06895,screening,-3.27,-3.2,0.023,0.0,0.023,0.253,0.098,0.521,0.18,0.435,0.104,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,230.4,0.81,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003991,176
p.E286A,WM-TP53-03087,WM-TP53-03087,screening,-3.22,-3.2,0.007,0.0,0.007,0.251,0.094,0.59,0.18,0.486,0.104,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004343,177
p.E286A,WM-TP53-06589,WM-TP53-06589,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.099,0.547,0.18,0.506,0.103,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,256.5,2.89,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,178
p.E286A,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.556,0.18,0.437,0.103,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.E286A,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.544,0.18,0.411,0.103,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.E286A,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.559,0.18,0.448,0.102,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.E286A,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.539,0.18,0.416,0.102,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.E286A,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.554,0.18,0.444,0.102,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.E286A,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.527,0.18,0.418,0.101,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.E286A,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.554,0.18,0.458,0.101,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.E286A,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.539,0.18,0.46,0.099,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.E286A,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.532,0.18,0.447,0.099,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.E286A,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.506,0.18,0.42,0.098,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.E286A,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.647,0.18,0.634,0.098,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.E286A,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.65,0.18,0.634,0.098,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.E286A,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.53,0.18,0.474,0.097,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.E286A,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.646,0.18,0.647,0.097,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.E286A,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.557,0.18,0.521,0.096,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.E286A,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.513,0.18,0.451,0.096,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.E286A,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.528,0.18,0.492,0.095,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.E286A,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.525,0.18,0.49,0.095,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.E286A,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.553,0.18,0.524,0.095,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.E286A,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.467,0.18,0.409,0.094,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.E286A,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.503,0.18,0.48,0.093,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.E286A,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.507,0.18,0.483,0.093,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.E286A,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.533,0.18,0.53,0.092,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.E286A,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.482,0.18,0.469,0.091,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.E286A,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.504,0.18,0.504,0.091,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.E286A,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.509,0.18,0.516,0.091,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.E286A,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.517,0.18,0.529,0.091,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.E286A,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.494,0.18,0.489,0.091,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.E286A,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.508,0.18,0.538,0.089,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.E286A,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.508,0.18,0.543,0.088,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.E286A,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.461,0.18,0.52,0.085,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.E286A,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.474,0.18,0.544,0.084,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.E286A,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.484,0.18,0.557,0.084,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.E286A,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.479,0.18,0.574,0.082,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.E286A,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.469,0.18,0.58,0.081,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.E286A,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.447,0.18,0.541,0.081,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.E286A,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.453,0.18,0.58,0.079,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.E286A,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.437,0.18,0.57,0.078,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.E286A,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.537,0.18,0.736,0.076,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.E286A,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.528,0.18,0.739,0.075,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.E286A,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.538,0.18,0.758,0.075,0.736,"C286,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.E286A,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.092,0.404,0.18,0.779,0.057,0.636,"C286,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.G154C,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.86,"C154,R158,M160,Y163",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.G154C,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.86,"C154,R158,M160,Y163",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.G154C,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.78,"C154,R158,M160,Y163",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.G154C,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.78,"C154,R158,M160,Y163",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.G154C,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.824,"C154,R158,M160,Y163",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.G154C,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.736,"C154,R158,M160,Y163",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.G154C,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.736,"C154,R158,M160,Y163",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.G154C,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.736,"C154,R158,M160,Y163",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.G154C,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.736,"C154,R158,M160,Y163",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.G154C,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.876,"C154,R158,M160,Y163",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.G154C,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.736,"C154,R158,M160,Y163",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.G154C,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.736,"C154,R158,M160,Y163",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.G154C,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.824,"C154,R158,M160,Y163",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.G154C,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.824,"C154,R158,M160,Y163",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.G154C,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.736,"C154,R158,M160,Y163",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.G154C,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.824,"C154,R158,M160,Y163",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.G154C,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.736,"C154,R158,M160,Y163",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.G154C,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.736,"C154,R158,M160,Y163",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.G154C,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.824,"C154,R158,M160,Y163",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.G154C,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.736,"C154,R158,M160,Y163",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.G154C,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.824,"C154,R158,M160,Y163",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.G154C,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.736,"C154,R158,M160,Y163",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.G154C,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.824,"C154,R158,M160,Y163",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.G154C,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.78,"C154,R158,M160,Y163",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.G154C,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.86,"C154,R158,M160,Y163",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.G154C,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.736,"C154,R158,M160,Y163",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.G154C,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.824,"C154,R158,M160,Y163",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.G154C,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.78,"C154,R158,M160,Y163",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.G154C,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.78,"C154,R158,M160,Y163",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.G154C,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.78,"C154,R158,M160,Y163",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.G154C,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.736,"C154,R158,M160,Y163",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.G154C,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.78,"C154,R158,M160,Y163",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.G154C,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.78,"C154,R158,M160,Y163",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.G154C,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.78,"C154,R158,M160,Y163",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.G154C,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.736,"C154,R158,M160,Y163",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.G154C,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.78,"C154,R158,M160,Y163",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.G154C,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.824,"C154,R158,M160,Y163",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.G154C,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.824,"C154,R158,M160,Y163",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.G154C,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.736,"C154,R158,M160,Y163",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.G154C,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.736,"C154,R158,M160,Y163",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.G154C,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.736,"C154,R158,M160,Y163",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.G154C,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.736,"C154,R158,M160,Y163",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.G154C,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.78,"C154,R158,M160,Y163",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.G154C,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.736,"C154,R158,M160,Y163",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.G154C,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.736,"C154,R158,M160,Y163",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.G154C,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.78,"C154,R158,M160,Y163",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.G154C,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.736,"C154,R158,M160,Y163",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.G154C,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.736,"C154,R158,M160,Y163",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.G154C,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.736,"C154,R158,M160,Y163",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.G154C,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.824,"C154,R158,M160,Y163",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.G154C,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.736,"C154,R158,M160,Y163",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.G154C,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.78,"C154,R158,M160,Y163",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.G154C,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.736,"C154,R158,M160,Y163",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.G154C,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.736,"C154,R158,M160,Y163",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.G154C,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.736,"C154,R158,M160,Y163",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.G154C,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.78,"C154,R158,M160,Y163",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.G154C,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.736,"C154,R158,M160,Y163",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.G154C,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.736,"C154,R158,M160,Y163",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.G154C,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.78,"C154,R158,M160,Y163",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.G154C,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.736,"C154,R158,M160,Y163",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.G154C,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.736,"C154,R158,M160,Y163",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.G154C,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.736,"C154,R158,M160,Y163",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.G154C,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.824,"C154,R158,M160,Y163",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.G154C,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.736,"C154,R158,M160,Y163",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.G154C,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.824,"C154,R158,M160,Y163",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.G154C,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.736,"C154,R158,M160,Y163",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.G154C,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.736,"C154,R158,M160,Y163",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.G154C,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.736,"C154,R158,M160,Y163",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.G154C,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.736,"C154,R158,M160,Y163",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.G154C,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.736,"C154,R158,M160,Y163",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.G154C,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.736,"C154,R158,M160,Y163",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.G154C,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.736,"C154,R158,M160,Y163",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.G154C,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.78,"C154,R158,M160,Y163",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.G154C,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.736,"C154,R158,M160,Y163",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.G154C,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.78,"C154,R158,M160,Y163",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.G154C,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.736,"C154,R158,M160,Y163",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.G154C,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.736,"C154,R158,M160,Y163",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.G154C,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.736,"C154,R158,M160,Y163",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.G154C,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.736,"C154,R158,M160,Y163",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.G154C,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.736,"C154,R158,M160,Y163",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.G154C,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.736,"C154,R158,M160,Y163",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.G154C,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.736,"C154,R158,M160,Y163",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.G154C,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.736,"C154,R158,M160,Y163",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.G154C,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.736,"C154,R158,M160,Y163",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.G154C,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.736,"C154,R158,M160,Y163",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.G154C,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.736,"C154,R158,M160,Y163",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.G154C,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.736,"C154,R158,M160,Y163",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.G154C,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.736,"C154,R158,M160,Y163",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.G154C,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.736,"C154,R158,M160,Y163",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.G154C,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.736,"C154,R158,M160,Y163",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.G154C,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.824,"C154,R158,M160,Y163",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.G154C,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.736,"C154,R158,M160,Y163",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.G154C,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.736,"C154,R158,M160,Y163",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.G154C,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.736,"C154,R158,M160,Y163",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.G154C,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.736,"C154,R158,M160,Y163",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.G154C,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.736,"C154,R158,M160,Y163",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.G154C,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.736,"C154,R158,M160,Y163",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.G154C,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.736,"C154,R158,M160,Y163",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.G154C,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.736,"C154,R158,M160,Y163",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.G154C,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.736,"C154,R158,M160,Y163",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.G154C,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.736,"C154,R158,M160,Y163",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.G154C,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.736,"C154,R158,M160,Y163",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.G154C,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.736,"C154,R158,M160,Y163",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.G154C,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.78,"C154,R158,M160,Y163",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.G154C,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.736,"C154,R158,M160,Y163",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.G154C,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.736,"C154,R158,M160,Y163",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.G154C,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.736,"C154,R158,M160,Y163",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.G154C,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.736,"C154,R158,M160,Y163",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.G154C,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.736,"C154,R158,M160,Y163",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.G154C,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.736,"C154,R158,M160,Y163",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.G154C,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.736,"C154,R158,M160,Y163",Pass,False,True,429.0,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.G154C,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.736,"C154,R158,M160,Y163",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.G154C,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.736,"C154,R158,M160,Y163",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.G154C,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.736,"C154,R158,M160,Y163",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.G154C,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.736,"C154,R158,M160,Y163",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.G154C,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.736,"C154,R158,M160,Y163",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.G154C,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.736,"C154,R158,M160,Y163",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.G154C,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.736,"C154,R158,M160,Y163",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.G154C,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.736,"C154,R158,M160,Y163",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.G154C,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.78,"C154,R158,M160,Y163",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.G154C,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.736,"C154,R158,M160,Y163",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.G154C,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.736,"C154,R158,M160,Y163",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.G154C,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.736,"C154,R158,M160,Y163",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.G154C,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.736,"C154,R158,M160,Y163",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.G154C,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.736,"C154,R158,M160,Y163",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.G154C,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.736,"C154,R158,M160,Y163",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.G154C,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.736,"C154,R158,M160,Y163",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.G154C,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.736,"C154,R158,M160,Y163",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.G154C,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.736,"C154,R158,M160,Y163",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.G154C,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.78,"C154,R158,M160,Y163",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.G154C,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.736,"C154,R158,M160,Y163",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.G154C,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.736,"C154,R158,M160,Y163",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.G154C,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.78,"C154,R158,M160,Y163",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.G154C,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.736,"C154,R158,M160,Y163",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.G154C,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.736,"C154,R158,M160,Y163",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.G154C,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.736,"C154,R158,M160,Y163",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.G154C,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.736,"C154,R158,M160,Y163",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.G154C,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.736,"C154,R158,M160,Y163",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.G154C,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.736,"C154,R158,M160,Y163",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.G154C,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.736,"C154,R158,M160,Y163",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.G154C,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.736,"C154,R158,M160,Y163",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.G154C,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.736,"C154,R158,M160,Y163",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.G154C,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.736,"C154,R158,M160,Y163",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.G154C,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.736,"C154,R158,M160,Y163",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.G154C,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.736,"C154,R158,M160,Y163",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.G154C,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.736,"C154,R158,M160,Y163",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.G154C,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.736,"C154,R158,M160,Y163",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.G154C,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.736,"C154,R158,M160,Y163",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.G154C,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.736,"C154,R158,M160,Y163",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.G154C,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.736,"C154,R158,M160,Y163",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.G154C,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.736,"C154,R158,M160,Y163",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.G154C,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.78,"C154,R158,M160,Y163",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.G154C,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.736,"C154,R158,M160,Y163",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.G154C,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.736,"C154,R158,M160,Y163",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.G154C,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.78,"C154,R158,M160,Y163",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.G154C,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.736,"C154,R158,M160,Y163",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.G154C,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.736,"C154,R158,M160,Y163",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.G154C,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.736,"C154,R158,M160,Y163",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.G154C,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.736,"C154,R158,M160,Y163",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.G154C,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.736,"C154,R158,M160,Y163",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.G154C,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.736,"C154,R158,M160,Y163",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.G154C,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.736,"C154,R158,M160,Y163",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.G154C,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.736,"C154,R158,M160,Y163",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.G154C,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.736,"C154,R158,M160,Y163",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.G154C,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.736,"C154,R158,M160,Y163",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.G154C,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.736,"C154,R158,M160,Y163",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.G154C,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.736,"C154,R158,M160,Y163",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.G154C,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.736,"C154,R158,M160,Y163",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.G154C,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.736,"C154,R158,M160,Y163",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.G154C,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.736,"C154,R158,M160,Y163",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.G154C,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.736,"C154,R158,M160,Y163",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.G154C,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.736,"C154,R158,M160,Y163",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.G154C,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.736,"C154,R158,M160,Y163",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.G154C,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.736,"C154,R158,M160,Y163",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.G154C,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.736,"C154,R158,M160,Y163",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.G154C,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.736,"C154,R158,M160,Y163",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.G154C,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.736,"C154,R158,M160,Y163",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.G154C,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.736,"C154,R158,M160,Y163",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.G154C,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.736,"C154,R158,M160,Y163",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.G154C,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.736,"C154,R158,M160,Y163",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.G154C,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.736,"C154,R158,M160,Y163",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.G154C,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.736,"C154,R158,M160,Y163",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.G154C,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.736,"C154,R158,M160,Y163",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.G154C,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.736,"C154,R158,M160,Y163",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.G154C,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.736,"C154,R158,M160,Y163",Pass,False,False,552.3,4.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.G154C,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.736,"C154,R158,M160,Y163",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.G154C,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.736,"C154,R158,M160,Y163",Pass,False,True,404.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.G154C,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.736,"C154,R158,M160,Y163",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.G154C,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.736,"C154,R158,M160,Y163",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.G154C,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.736,"C154,R158,M160,Y163",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.G154C,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.736,"C154,R158,M160,Y163",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.G154C,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.736,"C154,R158,M160,Y163",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.G154C,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.736,"C154,R158,M160,Y163",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.G154C,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.736,"C154,R158,M160,Y163",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.G154C,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.736,"C154,R158,M160,Y163",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.G154C,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.736,"C154,R158,M160,Y163",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.G154C,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.736,"C154,R158,M160,Y163",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.G154C,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.736,"C154,R158,M160,Y163",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.G154C,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.736,"C154,R158,M160,Y163",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.G154C,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.736,"C154,R158,M160,Y163",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.G154C,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.736,"C154,R158,M160,Y163",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.G154C,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.736,"C154,R158,M160,Y163",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.G154C,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.736,"C154,R158,M160,Y163",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.G154C,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.736,"C154,R158,M160,Y163",Pass,False,True,404.0,2.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.G154C,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.736,"C154,R158,M160,Y163",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.G154C,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.736,"C154,R158,M160,Y163",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.G154C,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.736,"C154,R158,M160,Y163",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.G154C,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.736,"C154,R158,M160,Y163",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.G154C,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.736,"C154,R158,M160,Y163",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.G154C,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.736,"C154,R158,M160,Y163",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.G154C,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.736,"C154,R158,M160,Y163",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.G154C,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.736,"C154,R158,M160,Y163",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.G154C,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.736,"C154,R158,M160,Y163",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.G154C,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.736,"C154,R158,M160,Y163",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.G154C,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.736,"C154,R158,M160,Y163",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.G154C,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.736,"C154,R158,M160,Y163",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.G154C,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.736,"C154,R158,M160,Y163",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.G154C,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.736,"C154,R158,M160,Y163",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.G154C,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.736,"C154,R158,M160,Y163",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.G154C,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.636,"C154,R158,M160,Y163",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.G244D,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.86,"C244,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.G244D,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.86,"C244,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.G244D,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.G244D,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.G244D,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.G244D,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.G244D,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.G244D,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.G244D,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.G244D,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.876,"C244,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.G244D,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.G244D,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.G244D,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.G244D,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.G244D,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.G244D,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.G244D,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.G244D,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.G244D,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.G244D,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.G244D,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.G244D,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.G244D,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.G244D,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.G244D,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.86,"C244,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.G244D,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.G244D,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.G244D,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.G244D,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.G244D,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.G244D,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.G244D,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.G244D,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.G244D,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.G244D,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.G244D,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.G244D,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.G244D,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.G244D,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.G244D,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.G244D,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.G244D,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.G244D,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.G244D,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.G244D,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.G244D,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.G244D,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.G244D,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.G244D,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.G244D,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.G244D,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.G244D,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.G244D,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.G244D,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.G244D,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.G244D,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.G244D,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.G244D,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.G244D,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.G244D,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.G244D,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.G244D,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.G244D,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.G244D,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.G244D,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.G244D,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.G244D,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.G244D,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.G244D,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.G244D,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.G244D,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.G244D,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.G244D,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.G244D,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.G244D,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.G244D,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.G244D,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.G244D,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.G244D,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.G244D,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.G244D,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.G244D,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.G244D,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.G244D,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.G244D,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.G244D,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.G244D,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.G244D,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.G244D,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.G244D,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.G244D,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.824,"C244,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.G244D,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.G244D,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.G244D,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.G244D,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.G244D,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.G244D,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.G244D,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.G244D,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.G244D,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.G244D,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.G244D,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.G244D,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.G244D,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.G244D,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.G244D,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.G244D,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.G244D,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.G244D,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.G244D,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.G244D,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,429.0,3.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.G244D,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.G244D,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.G244D,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.G244D,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.G244D,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.G244D,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.G244D,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.G244D,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.G244D,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.G244D,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.G244D,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.G244D,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.G244D,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.G244D,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.G244D,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.G244D,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.G244D,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.G244D,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.G244D,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.G244D,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.G244D,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.G244D,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.G244D,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.G244D,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.G244D,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.G244D,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.G244D,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.G244D,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.G244D,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.G244D,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.G244D,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.G244D,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.G244D,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.G244D,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.G244D,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.G244D,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.G244D,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.G244D,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.G244D,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.G244D,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.G244D,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.G244D,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.G244D,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.G244D,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.78,"C244,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.G244D,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.G244D,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.G244D,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.G244D,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.G244D,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.G244D,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.G244D,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.G244D,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.G244D,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.G244D,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.G244D,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.G244D,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.G244D,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.G244D,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.G244D,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.G244D,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.G244D,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.G244D,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.G244D,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.G244D,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.G244D,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.G244D,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.G244D,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.G244D,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.G244D,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.G244D,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.G244D,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.G244D,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.G244D,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.G244D,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,552.3,4.52,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.G244D,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.G244D,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,404.0,1.98,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.G244D,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.G244D,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.G244D,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.G244D,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.G244D,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.G244D,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.G244D,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.G244D,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.G244D,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.G244D,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.G244D,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.G244D,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.G244D,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.G244D,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.G244D,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.G244D,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.G244D,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,404.0,2.73,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.G244D,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.G244D,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.G244D,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.G244D,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.G244D,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.G244D,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.G244D,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.G244D,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.G244D,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.G244D,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.G244D,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.G244D,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.G244D,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.G244D,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.G244D,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.736,"C244,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.G244D,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.636,"C244,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.G245C,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.86,"C245,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.G245C,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.86,"C245,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.G245C,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.G245C,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.G245C,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.G245C,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.G245C,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.G245C,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.G245C,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.G245C,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.876,"C245,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.G245C,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.G245C,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.G245C,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.G245C,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.G245C,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.G245C,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.G245C,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.G245C,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.G245C,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.G245C,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.G245C,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.G245C,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.G245C,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.G245C,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.G245C,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.86,"C245,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.G245C,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.G245C,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.G245C,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.G245C,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.G245C,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.G245C,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.G245C,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.G245C,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.G245C,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.G245C,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.G245C,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.G245C,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.G245C,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.G245C,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.G245C,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.G245C,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.G245C,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.G245C,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.G245C,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.G245C,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.G245C,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.G245C,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.G245C,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.G245C,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.G245C,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.G245C,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.G245C,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.G245C,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.G245C,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.G245C,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.G245C,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.G245C,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.G245C,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.G245C,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.G245C,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.G245C,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.G245C,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.G245C,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.G245C,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.G245C,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.G245C,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.G245C,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.G245C,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.G245C,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.G245C,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.G245C,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.G245C,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.G245C,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.G245C,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.G245C,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.G245C,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.G245C,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.G245C,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.G245C,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.G245C,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.G245C,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.G245C,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.G245C,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.G245C,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.G245C,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.G245C,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.G245C,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.G245C,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.G245C,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.G245C,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.G245C,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.824,"C245,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.G245C,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.G245C,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.G245C,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.G245C,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.G245C,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.G245C,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.G245C,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.G245C,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.G245C,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.G245C,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.G245C,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.G245C,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.G245C,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.G245C,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.G245C,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.G245C,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.G245C,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.G245C,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.G245C,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.G245C,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,429.0,3.18,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.G245C,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.G245C,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.G245C,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.G245C,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.G245C,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.G245C,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.G245C,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.G245C,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.G245C,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.G245C,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.G245C,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.G245C,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.G245C,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.G245C,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.G245C,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.G245C,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.G245C,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.G245C,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.G245C,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.G245C,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.G245C,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.G245C,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.G245C,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.G245C,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.G245C,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.G245C,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.G245C,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.G245C,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.G245C,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.G245C,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.G245C,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.G245C,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.G245C,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.G245C,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.G245C,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.G245C,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.G245C,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.G245C,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.G245C,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.G245C,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.G245C,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.G245C,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.G245C,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.G245C,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.78,"C245,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.G245C,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.G245C,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.G245C,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.G245C,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.G245C,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.G245C,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.G245C,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.G245C,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.G245C,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.G245C,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.G245C,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.G245C,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.G245C,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.G245C,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.G245C,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.G245C,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.G245C,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.G245C,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.G245C,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.G245C,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.G245C,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.G245C,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.G245C,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.G245C,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.G245C,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.G245C,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.G245C,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.G245C,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.G245C,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.G245C,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,552.3,4.52,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.G245C,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.G245C,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,404.0,1.98,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.G245C,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.G245C,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.G245C,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.G245C,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.G245C,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.G245C,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.G245C,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.G245C,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.G245C,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.G245C,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.G245C,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.G245C,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.G245C,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.G245C,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.G245C,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.G245C,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.G245C,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,404.0,2.73,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.G245C,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.G245C,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.G245C,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.G245C,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.G245C,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.G245C,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.G245C,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.G245C,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.G245C,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.G245C,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.G245C,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.G245C,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.G245C,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.G245C,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.G245C,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.736,"C245,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.G245C,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.636,"C245,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,Structural / cavity or core,Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.K132N,CTRL-001,PK083,preclinical,-5.57,-3.31,0.753,0.196,0.753,0.471,0.544,0.645,0.8,0.363,0.459,0.86,"C132,R158,M160,Y163",Pass,True,True,238.3,3.85,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"known-ligand-control,mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,8.2e-05,1
p.K132N,WM-TP53-00860,WM-TP53-00860,preclinical,-5.09,-3.26,0.61,0.136,0.61,0.416,0.4,0.719,0.4,0.292,0.365,0.78,"C132,R158,M160,Y163",Pass,False,True,224.4,3.45,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000184,2
p.K132N,WM-TP53-05841,WM-TP53-05841,clinical,-4.67,-3.2,0.49,0.084,0.49,0.37,0.345,0.731,0.62,0.249,0.344,0.824,"C132,R158,M160,Y163",Pass,False,True,245.7,2.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000375,3
p.K132N,WM-TP53-07201,WM-TP53-07201,screening,-5.22,-3.73,0.497,0.152,0.497,0.408,0.375,0.758,0.18,0.234,0.331,0.736,"C132,R158,M160,Y163",Pass,False,True,219.3,2.54,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000148,4
p.K132N,WM-TP53-01421,WM-TP53-01421,screening,-5.03,-3.2,0.61,0.129,0.61,0.412,0.397,0.561,0.18,0.321,0.319,0.736,"C132,R158,M160,Y163",Pass,False,True,233.3,3.9,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000204,5
p.K132N,WM-TP53-00146,WM-TP53-00146,screening,-4.91,-3.39,0.507,0.114,0.507,0.389,0.362,0.769,0.18,0.273,0.318,0.736,"C132,R158,M160,Y163",Pass,False,True,204.8,3.17,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00025,6
p.K132N,WM-TP53-06487,WM-TP53-06487,screening,-4.95,-3.2,0.583,0.119,0.583,0.403,0.385,0.637,0.18,0.382,0.313,0.736,"C132,R158,M160,Y163",Pass,False,True,302.0,4.96,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000234,7
p.K132N,WM-TP53-00707,WM-TP53-00707,screening,-4.62,-3.2,0.473,0.078,0.473,0.364,0.337,0.792,0.18,0.24,0.302,0.736,"C132,R158,M160,Y163",Pass,False,True,260.5,2.63,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000408,8
p.K132N,CTRL-003,PK11000,preclinical,-3.86,-3.2,0.22,0.0,0.22,0.283,0.315,0.854,0.8,0.171,0.298,0.86,"C132,R158,M160,Y163",Pass,True,True,236.6,1.15,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001473,9
p.K132N,WM-TP53-06028,WM-TP53-06028,screening,-4.77,-3.2,0.523,0.096,0.523,0.381,0.359,0.644,0.18,0.374,0.292,0.736,"C132,R158,M160,Y163",Pass,False,True,292.0,4.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000317,10
p.K132N,WM-TP53-04481,WM-TP53-04481,preclinical,-4.48,-3.2,0.427,0.06,0.427,0.347,0.317,0.711,0.4,0.321,0.29,0.78,"C132,R158,M160,Y163",Pass,False,True,275.4,3.9,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000517,11
p.K132N,WM-TP53-01438,WM-TP53-01438,screening,-4.74,-3.6,0.38,0.093,0.38,0.358,0.317,0.779,0.18,0.212,0.285,0.736,"C132,R158,M160,Y163",Pass,False,True,198.0,2.13,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000333,12
p.K132N,WM-TP53-05637,WM-TP53-05637,screening,-4.56,-3.22,0.447,0.07,0.447,0.356,0.327,0.716,0.18,0.26,0.282,0.736,"C132,R158,M160,Y163",Pass,False,True,191.7,2.96,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000452,13
p.K132N,WM-TP53-02322,WM-TP53-02322,preclinical,-4.58,-3.78,0.267,0.073,0.267,0.33,0.278,0.812,0.4,0.176,0.279,0.78,"C132,R158,M160,Y163",Pass,False,True,180.0,1.28,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000437,14
p.K132N,WM-TP53-01795,WM-TP53-01795,screening,-4.6,-3.25,0.45,0.075,0.45,0.359,0.33,0.61,0.18,0.217,0.275,0.736,"C132,R158,M160,Y163",Pass,False,True,233.2,2.22,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000422,15
p.K132N,WM-TP53-05365,WM-TP53-05365,screening,-4.54,-3.2,0.447,0.068,0.447,0.354,0.326,0.694,0.18,0.366,0.27,0.736,"C132,R158,M160,Y163",Pass,False,True,269.4,3.91,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000467,16
p.K132N,WM-TP53-06079,WM-TP53-06079,screening,-4.39,-3.2,0.397,0.049,0.397,0.336,0.304,0.778,0.18,0.257,0.269,0.736,"C132,R158,M160,Y163",Pass,False,True,259.7,2.91,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000602,17
p.K132N,WM-TP53-06555,WM-TP53-06555,screening,-4.47,-3.2,0.423,0.059,0.423,0.346,0.316,0.719,0.18,0.329,0.267,0.736,"C132,R158,M160,Y163",Pass,False,True,265.4,4.03,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000526,18
p.K132N,WM-TP53-06623,WM-TP53-06623,screening,-4.39,-3.2,0.397,0.049,0.397,0.336,0.304,0.727,0.18,0.242,0.264,0.736,"C132,R158,M160,Y163",Pass,False,True,244.5,2.67,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000602,19
p.K132N,WM-TP53-03546,WM-TP53-03546,screening,-4.36,-3.2,0.387,0.045,0.387,0.333,0.3,0.757,0.18,0.272,0.262,0.736,"C132,R158,M160,Y163",Pass,False,True,242.1,3.14,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000633,20
p.K132N,WM-TP53-07949,WM-TP53-07949,approved,-3.99,-3.2,0.263,0.0,0.263,0.289,0.247,0.651,0.72,0.244,0.259,0.844,"C132,R158,M160,Y163",Pass,False,True,255.6,2.69,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,21
p.K132N,WM-TP53-02764,WM-TP53-02764,screening,-4.25,-3.2,0.35,0.031,0.35,0.32,0.284,0.781,0.18,0.191,0.257,0.736,"C132,R158,M160,Y163",Pass,False,True,221.3,1.67,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000762,22
p.K132N,WM-TP53-03410,WM-TP53-03410,screening,-4.25,-3.2,0.35,0.031,0.35,0.32,0.284,0.79,0.18,0.229,0.255,0.736,"C132,R158,M160,Y163",Pass,False,True,185.6,2.44,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000762,23
p.K132N,WM-TP53-00367,WM-TP53-00367,screening,-4.38,-3.2,0.393,0.047,0.393,0.335,0.302,0.638,0.18,0.228,0.253,0.736,"C132,R158,M160,Y163",Pass,False,True,248.0,2.43,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,24
p.K132N,WM-TP53-01676,WM-TP53-01676,clinical,-3.99,-3.2,0.263,0.0,0.263,0.289,0.247,0.708,0.62,0.333,0.248,0.824,"C132,R158,M160,Y163",Pass,False,True,278.8,3.35,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,25
p.K132N,WM-TP53-05280,WM-TP53-05280,screening,-4.55,-3.76,0.263,0.069,0.263,0.327,0.275,0.699,0.18,0.188,0.24,0.736,"C132,R158,M160,Y163",Pass,False,True,180.0,1.59,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000459,26
p.K132N,WM-TP53-02798,WM-TP53-02798,screening,-4.12,-3.2,0.307,0.015,0.307,0.304,0.265,0.767,0.18,0.225,0.236,0.736,"C132,R158,M160,Y163",Pass,False,True,243.8,2.37,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,27
p.K132N,WM-TP53-04600,WM-TP53-04600,screening,-4.04,-3.2,0.28,0.005,0.28,0.295,0.254,0.791,0.18,0.204,0.231,0.736,"C132,R158,M160,Y163",Pass,False,True,213.7,1.97,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001087,28
p.K132N,WM-TP53-04056,WM-TP53-04056,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.247,0.798,0.18,0.198,0.226,0.736,"C132,R158,M160,Y163",Pass,False,True,244.9,1.84,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,29
p.K132N,WM-TP53-05977,WM-TP53-05977,screening,-4.11,-3.2,0.303,0.014,0.303,0.303,0.263,0.705,0.18,0.266,0.224,0.736,"C132,R158,M160,Y163",Pass,False,True,301.7,3.06,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000966,30
p.K132N,CTRL-002,PK7088,preclinical,-3.78,-3.2,0.193,0.0,0.193,0.279,0.307,0.609,0.8,0.653,0.223,0.86,"C132,R158,M160,Y163",Pass,True,True,364.2,4.7,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001686,31
p.K132N,WM-TP53-05331,WM-TP53-05331,screening,-4.07,-3.2,0.29,0.009,0.29,0.298,0.258,0.688,0.18,0.222,0.221,0.736,"C132,R158,M160,Y163",Pass,False,True,246.1,2.31,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001033,32
p.K132N,WM-TP53-06810,WM-TP53-06810,clinical,-4.08,-3.2,0.293,0.01,0.293,0.299,0.259,0.508,0.62,0.543,0.219,0.824,"C132,R158,M160,Y163",Pass,False,True,180.0,2.74,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001016,33
p.K132N,WM-TP53-06249,WM-TP53-06249,screening,-3.97,-3.2,0.257,0.0,0.257,0.289,0.245,0.76,0.18,0.217,0.219,0.736,"C132,R158,M160,Y163",Pass,False,True,273.1,2.22,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001223,34
p.K132N,WM-TP53-07575,WM-TP53-07575,preclinical,-3.72,-3.2,0.173,0.0,0.173,0.276,0.221,0.786,0.4,0.275,0.219,0.78,"C132,R158,M160,Y163",Pass,False,True,299.7,3.2,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001866,35
p.K132N,WM-TP53-07609,WM-TP53-07609,screening,-3.97,-3.2,0.257,0.0,0.257,0.289,0.245,0.763,0.18,0.245,0.217,0.736,"C132,R158,M160,Y163",Pass,False,True,275.3,2.72,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001223,36
p.K132N,WM-TP53-08000,WM-TP53-08000,screening,-4.03,-3.2,0.277,0.004,0.277,0.294,0.252,0.688,0.18,0.224,0.216,0.736,"C132,R158,M160,Y163",Pass,False,True,235.4,2.36,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001106,37
p.K132N,WM-TP53-02475,WM-TP53-02475,screening,-4.0,-3.2,0.267,0.0,0.267,0.29,0.248,0.756,0.18,0.292,0.215,0.736,"C132,R158,M160,Y163",Pass,False,True,268.7,3.45,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001163,38
p.K132N,WM-TP53-04923,WM-TP53-04923,preclinical,-3.73,-3.2,0.177,0.0,0.177,0.277,0.223,0.735,0.4,0.252,0.215,0.78,"C132,R158,M160,Y163",Pass,False,True,273.1,2.83,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001835,39
p.K132N,WM-TP53-04991,WM-TP53-04991,screening,-4.0,-3.2,0.267,0.0,0.267,0.29,0.248,0.68,0.18,0.202,0.213,0.736,"C132,R158,M160,Y163",Pass,False,True,231.0,1.92,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001163,40
p.K132N,WM-TP53-03988,WM-TP53-03988,screening,-4.27,-3.2,0.357,0.034,0.357,0.322,0.287,0.555,0.18,0.463,0.211,0.736,"C132,R158,M160,Y163",Pass,False,True,256.1,2.15,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,41
p.K132N,WM-TP53-01217,WM-TP53-01217,screening,-4.71,-3.83,0.293,0.089,0.293,0.343,0.291,0.509,0.18,0.491,0.208,0.736,"C132,R158,M160,Y163",Pass,False,True,181.1,1.91,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000351,42
p.K132N,WM-TP53-05586,WM-TP53-05586,screening,-4.08,-3.42,0.22,0.01,0.22,0.288,0.239,0.688,0.18,0.172,0.208,0.736,"C132,R158,M160,Y163",Pass,False,True,180.0,1.18,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001016,43
p.K132N,WM-TP53-06997,WM-TP53-06997,screening,-3.93,-3.2,0.243,0.0,0.243,0.286,0.241,0.703,0.18,0.237,0.207,0.736,"C132,R158,M160,Y163",Pass,False,True,258.1,2.58,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001309,44
p.K132N,WM-TP53-03172,WM-TP53-03172,screening,-3.75,-3.2,0.183,0.0,0.183,0.277,0.224,0.797,0.18,0.189,0.207,0.736,"C132,R158,M160,Y163",Pass,False,True,241.8,1.63,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001774,45
p.K132N,WM-TP53-05501,WM-TP53-05501,clinical,-3.23,-3.2,0.01,0.0,0.01,0.252,0.176,0.799,0.62,0.231,0.206,0.824,"C132,R158,M160,Y163",Pass,False,True,297.2,2.47,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00427,46
p.K132N,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.807,0.62,0.228,0.205,0.824,"C132,R158,M160,Y163",Pass,False,True,316.9,2.42,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.K132N,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.253,0.599,0.88,0.388,0.204,0.876,"C132,R158,M160,Y163",Pass,True,False,548.6,3.4,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.K132N,WM-TP53-02305,WM-TP53-02305,screening,-4.02,-3.2,0.273,0.002,0.273,0.292,0.25,0.668,0.18,0.35,0.201,0.736,"C132,R158,M160,Y163",Pass,False,True,324.3,4.37,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001124,49
p.K132N,WM-TP53-05926,WM-TP53-05926,screening,-3.91,-3.2,0.237,0.0,0.237,0.286,0.239,0.66,0.18,0.224,0.201,0.736,"C132,R158,M160,Y163",Pass,False,True,246.6,2.35,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001354,50
p.K132N,WM-TP53-06538,WM-TP53-06538,screening,-3.79,-3.2,0.197,0.0,0.197,0.28,0.228,0.742,0.18,0.222,0.201,0.736,"C132,R158,M160,Y163",Pass,False,True,246.6,2.32,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001658,51
p.K132N,WM-TP53-01625,WM-TP53-01625,screening,-3.84,-3.2,0.213,0.0,0.213,0.282,0.233,0.694,0.18,0.212,0.2,0.736,"C132,R158,M160,Y163",Pass,False,True,237.4,2.12,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001524,52
p.K132N,WM-TP53-02526,WM-TP53-02526,screening,-4.63,-3.8,0.277,0.079,0.277,0.335,0.283,0.505,0.18,0.495,0.199,0.736,"C132,R158,M160,Y163",Pass,False,True,180.0,1.98,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000401,53
p.K132N,WM-TP53-00214,WM-TP53-00214,screening,-3.81,-3.2,0.203,0.0,0.203,0.28,0.23,0.742,0.18,0.267,0.199,0.736,"C132,R158,M160,Y163",Pass,False,True,243.1,2.33,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,54
p.K132N,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.781,0.62,0.256,0.199,0.824,"C132,R158,M160,Y163",Pass,False,True,301.9,2.17,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.K132N,WM-TP53-07048,WM-TP53-07048,screening,-4.11,-3.2,0.303,0.014,0.303,0.303,0.263,0.592,0.18,0.433,0.197,0.736,"C132,R158,M160,Y163",Pass,False,True,228.8,1.49,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000966,56
p.K132N,WM-TP53-04294,WM-TP53-04294,screening,-3.61,-3.2,0.137,0.0,0.137,0.271,0.211,0.801,0.18,0.201,0.196,0.736,"C132,R158,M160,Y163",Pass,False,True,251.6,1.9,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002247,57
p.K132N,WM-TP53-03121,WM-TP53-03121,screening,-3.83,-3.2,0.21,0.0,0.21,0.281,0.232,0.687,0.18,0.295,0.192,0.736,"C132,R158,M160,Y163",Pass,False,True,295.8,3.5,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00155,58
p.K132N,WM-TP53-01982,WM-TP53-01982,screening,-3.57,-3.2,0.123,0.0,0.123,0.268,0.207,0.785,0.18,0.179,0.192,0.736,"C132,R158,M160,Y163",Pass,False,True,226.1,1.39,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002405,59
p.K132N,WM-TP53-05416,WM-TP53-05416,screening,-3.86,-3.2,0.22,0.0,0.22,0.283,0.235,0.666,0.18,0.328,0.189,0.736,"C132,R158,M160,Y163",Pass,False,True,329.0,4.0,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001473,60
p.K132N,WM-TP53-02951,WM-TP53-02951,screening,-3.8,-3.2,0.2,0.0,0.2,0.28,0.229,0.681,0.18,0.334,0.186,0.736,"C132,R158,M160,Y163",Pass,False,True,327.6,4.1,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00163,61
p.K132N,WM-TP53-03444,WM-TP53-03444,screening,-3.8,-3.2,0.2,0.0,0.2,0.28,0.229,0.681,0.18,0.33,0.186,0.736,"C132,R158,M160,Y163",Pass,False,True,310.9,3.31,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00163,62
p.K132N,WM-TP53-06521,WM-TP53-06521,clinical,-3.43,-3.2,0.077,0.0,0.077,0.262,0.195,0.563,0.62,0.33,0.186,0.824,"C132,R158,M160,Y163",Pass,False,True,302.6,3.3,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,63
p.K132N,WM-TP53-06589,WM-TP53-06589,screening,-4.1,-3.2,0.3,0.012,0.3,0.302,0.262,0.547,0.18,0.506,0.185,0.736,"C132,R158,M160,Y163",Pass,False,True,256.5,2.89,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000982,64
p.K132N,WM-TP53-05705,WM-TP53-05705,screening,-4.09,-3.31,0.26,0.011,0.26,0.295,0.25,0.601,0.18,0.452,0.185,0.736,"C132,R158,M160,Y163",Pass,False,True,206.4,1.19,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000999,65
p.K132N,WM-TP53-05246,WM-TP53-05246,preclinical,-3.9,-3.22,0.227,0.0,0.227,0.284,0.237,0.507,0.4,0.436,0.185,0.78,"C132,R158,M160,Y163",Pass,False,True,180.0,1.56,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001377,66
p.K132N,WM-TP53-06232,WM-TP53-06232,preclinical,-3.29,-3.2,0.03,0.0,0.03,0.255,0.181,0.759,0.4,0.226,0.185,0.78,"C132,R158,M160,Y163",Pass,False,True,281.9,1.65,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,67
p.K132N,WM-TP53-02747,WM-TP53-02747,preclinical,-3.47,-3.2,0.09,0.0,0.09,0.264,0.198,0.651,0.4,0.256,0.184,0.78,"C132,R158,M160,Y163",Pass,False,True,232.3,2.16,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002847,68
p.K132N,WM-TP53-01727,WM-TP53-01727,screening,-3.43,-3.2,0.077,0.0,0.077,0.262,0.195,0.812,0.18,0.209,0.182,0.736,"C132,R158,M160,Y163",Pass,False,True,247.7,2.06,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,69
p.K132N,WM-TP53-03376,WM-TP53-03376,screening,-3.43,-3.2,0.077,0.0,0.077,0.262,0.195,0.791,0.18,0.174,0.182,0.736,"C132,R158,M160,Y163",Pass,False,True,230.4,1.24,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,70
p.K132N,WM-TP53-06198,WM-TP53-06198,screening,-3.55,-3.2,0.117,0.0,0.117,0.268,0.206,0.752,0.18,0.249,0.181,0.736,"C132,R158,M160,Y163",Pass,False,True,306.3,2.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002487,71
p.K132N,WM-TP53-05518,WM-TP53-05518,clinical,-3.5,-3.2,0.1,0.0,0.1,0.265,0.201,0.518,0.62,0.429,0.178,0.824,"C132,R158,M160,Y163",Pass,False,True,244.4,1.37,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002706,72
p.K132N,WM-TP53-04090,WM-TP53-04090,screening,-3.8,-3.2,0.2,0.0,0.2,0.28,0.229,0.593,0.18,0.328,0.176,0.736,"C132,R158,M160,Y163",Pass,False,True,308.3,4.01,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00163,73
p.K132N,WM-TP53-07898,WM-TP53-07898,screening,-4.04,-3.2,0.28,0.005,0.28,0.295,0.254,0.529,0.18,0.512,0.175,0.736,"C132,R158,M160,Y163",Pass,False,True,293.4,2.99,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001087,74
p.K132N,WM-TP53-04430,WM-TP53-04430,preclinical,-3.36,-3.2,0.053,0.0,0.053,0.258,0.188,0.696,0.4,0.325,0.175,0.78,"C132,R158,M160,Y163",Pass,False,True,337.5,3.96,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,75
p.K132N,WM-TP53-03087,WM-TP53-03087,screening,-3.94,-3.2,0.247,0.0,0.247,0.287,0.242,0.59,0.18,0.486,0.174,0.736,"C132,R158,M160,Y163",Pass,False,True,250.6,2.57,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001287,76
p.K132N,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.61,0.62,0.315,0.174,0.824,"C132,R158,M160,Y163",Pass,False,False,562.0,2.18,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.K132N,WM-TP53-01064,WM-TP53-01064,screening,-3.4,-3.2,0.067,0.0,0.067,0.26,0.192,0.776,0.18,0.234,0.173,0.736,"C132,R158,M160,Y163",Pass,False,True,277.7,1.79,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003204,78
p.K132N,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.696,0.4,0.189,0.173,0.78,"C132,R158,M160,Y163",Pass,False,True,340.8,1.63,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.K132N,WM-TP53-05671,WM-TP53-05671,screening,-3.93,-3.2,0.243,0.0,0.243,0.286,0.241,0.577,0.18,0.482,0.172,0.736,"C132,R158,M160,Y163",Pass,False,True,248.0,2.49,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001309,80
p.K132N,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.695,0.4,0.206,0.171,0.78,"C132,R158,M160,Y163",Pass,False,True,328.2,2.01,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.K132N,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.694,0.4,0.203,0.171,0.78,"C132,R158,M160,Y163",Pass,False,True,329.1,1.95,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.K132N,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.736,0.4,0.272,0.171,0.78,"C132,R158,M160,Y163",Pass,False,True,360.3,3.14,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.K132N,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.728,0.4,0.262,0.171,0.78,"C132,R158,M160,Y163",Pass,False,True,337.0,2.99,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.K132N,WM-TP53-04583,WM-TP53-04583,screening,-3.53,-3.2,0.11,0.0,0.11,0.267,0.204,0.657,0.18,0.238,0.169,0.736,"C132,R158,M160,Y163",Pass,False,True,265.7,1.87,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002573,85
p.K132N,WM-TP53-05739,WM-TP53-05739,screening,-3.84,-3.2,0.213,0.0,0.213,0.282,0.233,0.575,0.18,0.434,0.168,0.736,"C132,R158,M160,Y163",Pass,False,True,222.6,1.5,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001524,86
p.K132N,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.565,0.62,0.339,0.167,0.824,"C132,R158,M160,Y163",Pass,False,True,339.0,3.45,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.K132N,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.627,0.62,0.426,0.167,0.824,"C132,R158,M160,Y163",Pass,False,True,289.5,1.29,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.K132N,WM-TP53-06402,WM-TP53-06402,screening,-3.86,-3.32,0.18,0.0,0.18,0.277,0.223,0.615,0.18,0.418,0.166,0.736,"C132,R158,M160,Y163",Pass,False,True,180.0,1.06,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001473,89
p.K132N,WM-TP53-04260,WM-TP53-04260,screening,-3.45,-3.2,0.083,0.0,0.083,0.262,0.196,0.719,0.18,0.288,0.166,0.736,"C132,R158,M160,Y163",Pass,False,True,319.5,3.4,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002945,90
p.K132N,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.821,0.18,0.182,0.166,0.736,"C132,R158,M160,Y163",Pass,False,True,235.9,1.44,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.K132N,WM-TP53-06351,WM-TP53-06351,screening,-3.55,-3.2,0.117,0.0,0.117,0.268,0.206,0.643,0.18,0.282,0.165,0.736,"C132,R158,M160,Y163",Pass,False,True,294.4,2.57,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002487,92
p.K132N,WM-TP53-03648,WM-TP53-03648,screening,-3.33,-3.2,0.043,0.0,0.043,0.256,0.185,0.758,0.18,0.233,0.165,0.736,"C132,R158,M160,Y163",Pass,False,True,282.1,2.51,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003607,93
p.K132N,WM-TP53-01472,WM-TP53-01472,screening,-3.92,-3.2,0.24,0.0,0.24,0.286,0.24,0.522,0.18,0.496,0.164,0.736,"C132,R158,M160,Y163",Pass,False,True,228.0,2.74,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001331,94
p.K132N,WM-TP53-01353,WM-TP53-01353,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.184,0.775,0.18,0.264,0.164,0.736,"C132,R158,M160,Y163",Pass,False,True,300.0,2.29,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,95
p.K132N,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.797,0.18,0.171,0.164,0.736,"C132,R158,M160,Y163",Pass,False,True,307.8,1.16,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.K132N,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.785,0.18,0.159,0.164,0.736,"C132,R158,M160,Y163",Pass,False,True,332.6,0.73,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.K132N,WM-TP53-07286,WM-TP53-07286,screening,-3.9,-3.2,0.233,0.0,0.233,0.285,0.238,0.626,0.18,0.634,0.163,0.736,"C132,R158,M160,Y163",Pass,False,True,351.2,4.99,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001377,98
p.K132N,WM-TP53-04073,WM-TP53-04073,screening,-3.47,-3.2,0.09,0.0,0.09,0.264,0.198,0.646,0.18,0.235,0.163,0.736,"C132,R158,M160,Y163",Pass,False,True,273.9,2.55,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002847,99
p.K132N,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.804,0.18,0.197,0.163,0.736,"C132,R158,M160,Y163",Pass,False,True,316.8,1.81,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.K132N,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.698,0.4,0.315,0.163,0.78,"C132,R158,M160,Y163",Pass,False,True,320.1,3.08,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,101
p.K132N,WM-TP53-00299,WM-TP53-00299,screening,-3.81,-3.2,0.203,0.0,0.203,0.28,0.23,0.581,0.18,0.488,0.162,0.736,"C132,R158,M160,Y163",Pass,False,True,236.9,1.86,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,102
p.K132N,WM-TP53-06572,WM-TP53-06572,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.187,0.746,0.18,0.269,0.162,0.736,"C132,R158,M160,Y163",Pass,False,True,281.5,2.37,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,103
p.K132N,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.579,0.62,0.419,0.162,0.824,"C132,R158,M160,Y163",Pass,False,True,372.3,1.08,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.K132N,WM-TP53-03223,WM-TP53-03223,screening,-3.75,-3.2,0.183,0.0,0.183,0.277,0.224,0.597,0.18,0.464,0.161,0.736,"C132,R158,M160,Y163",Pass,False,True,244.4,2.16,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001774,105
p.K132N,WM-TP53-05093,WM-TP53-05093,screening,-3.82,-3.2,0.207,0.0,0.207,0.281,0.231,0.523,0.18,0.447,0.16,0.736,"C132,R158,M160,Y163",Pass,False,True,215.5,1.82,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001576,106
p.K132N,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.754,0.18,0.159,0.16,0.736,"C132,R158,M160,Y163",Pass,False,True,213.0,0.73,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.K132N,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.756,0.18,0.168,0.159,0.736,"C132,R158,M160,Y163",Pass,False,True,336.2,1.06,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.K132N,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.767,0.18,0.19,0.159,0.736,"C132,R158,M160,Y163",Pass,False,True,320.9,1.66,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.K132N,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.677,0.4,0.34,0.158,0.78,"C132,R158,M160,Y163",Pass,False,True,451.4,4.2,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.K132N,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.528,0.62,0.412,0.157,0.824,"C132,R158,M160,Y163",Pass,False,True,314.4,0.85,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.K132N,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.591,0.4,0.221,0.157,0.78,"C132,R158,M160,Y163",Pass,False,True,470.9,2.3,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.K132N,WM-TP53-01965,WM-TP53-01965,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.181,0.727,0.18,0.268,0.155,0.736,"C132,R158,M160,Y163",Pass,False,True,311.1,3.09,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,113
p.K132N,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.75,0.18,0.221,0.155,0.736,"C132,R158,M160,Y163",Pass,False,True,329.1,2.3,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.K132N,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.546,0.62,0.455,0.155,0.824,"C132,R158,M160,Y163",Pass,False,True,429.4,1.99,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.K132N,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.721,0.18,0.178,0.154,0.736,"C132,R158,M160,Y163",Pass,False,True,312.3,1.34,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.K132N,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.743,0.18,0.215,0.154,0.736,"C132,R158,M160,Y163",Pass,False,True,362.5,2.18,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.K132N,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.706,0.18,0.17,0.153,0.736,"C132,R158,M160,Y163",Pass,False,True,332.5,1.12,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.K132N,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.633,0.4,0.339,0.153,0.78,"C132,R158,M160,Y163",Pass,False,True,404.2,4.19,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.K132N,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.754,0.18,0.248,0.153,0.736,"C132,R158,M160,Y163",Pass,False,True,333.8,2.76,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.K132N,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.744,0.18,0.235,0.153,0.736,"C132,R158,M160,Y163",Pass,False,True,336.7,2.55,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.K132N,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.73,0.18,0.221,0.152,0.736,"C132,R158,M160,Y163",Pass,False,True,487.1,2.3,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.K132N,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.734,0.18,0.227,0.152,0.736,"C132,R158,M160,Y163",Pass,False,True,332.2,2.41,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.K132N,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.735,0.18,0.231,0.152,0.736,"C132,R158,M160,Y163",Pass,False,True,422.0,2.48,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.K132N,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.733,0.18,0.231,0.152,0.736,"C132,R158,M160,Y163",Pass,False,True,386.6,2.48,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.K132N,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.746,0.18,0.249,0.152,0.736,"C132,R158,M160,Y163",Pass,False,True,401.6,2.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.K132N,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.764,0.18,0.286,0.151,0.736,"C132,R158,M160,Y163",Pass,False,True,327.7,2.62,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.K132N,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.731,0.18,0.244,0.15,0.736,"C132,R158,M160,Y163",Pass,False,True,353.4,2.7,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.K132N,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.494,0.62,0.45,0.149,0.824,"C132,R158,M160,Y163",Pass,False,True,396.5,1.88,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.K132N,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.686,0.18,0.196,0.149,0.736,"C132,R158,M160,Y163",Pass,False,True,360.5,1.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.K132N,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.716,0.18,0.249,0.148,0.736,"C132,R158,M160,Y163",Pass,False,True,370.7,2.78,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.K132N,WM-TP53-02186,WM-TP53-02186,screening,-3.43,-3.2,0.077,0.0,0.077,0.262,0.195,0.631,0.18,0.376,0.147,0.736,"C132,R158,M160,Y163",Pass,False,True,361.1,4.84,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,132
p.K132N,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.724,0.18,0.275,0.147,0.736,"C132,R158,M160,Y163",Pass,False,True,457.6,3.2,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.K132N,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.69,0.18,0.223,0.147,0.736,"C132,R158,M160,Y163",Pass,False,True,316.5,2.34,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.K132N,WM-TP53-00231,WM-TP53-00231,screening,-3.68,-3.2,0.16,0.0,0.16,0.274,0.218,0.557,0.18,0.521,0.146,0.736,"C132,R158,M160,Y163",Pass,False,True,294.1,3.13,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,135
p.K132N,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.712,0.18,0.272,0.146,0.736,"C132,R158,M160,Y163",Pass,False,True,480.9,3.15,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.K132N,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.721,0.18,0.288,0.146,0.736,"C132,R158,M160,Y163",Pass,False,True,370.6,3.4,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.K132N,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.598,0.4,0.377,0.146,0.78,"C132,R158,M160,Y163",Pass,False,True,364.7,4.85,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.K132N,WM-TP53-02917,WM-TP53-02917,screening,-3.58,-3.2,0.127,0.0,0.127,0.269,0.209,0.554,0.18,0.444,0.144,0.736,"C132,R158,M160,Y163",Pass,False,True,243.0,1.73,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002364,139
p.K132N,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.709,0.18,0.289,0.144,0.736,"C132,R158,M160,Y163",Pass,False,True,385.0,2.68,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.K132N,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.705,0.18,0.293,0.143,0.736,"C132,R158,M160,Y163",Pass,False,True,455.0,3.46,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.K132N,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.706,0.18,0.31,0.142,0.736,"C132,R158,M160,Y163",Pass,False,True,409.8,2.99,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.K132N,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.679,0.18,0.301,0.14,0.736,"C132,R158,M160,Y163",Pass,False,True,483.6,3.59,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,143
p.K132N,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.686,0.18,0.307,0.14,0.736,"C132,R158,M160,Y163",Pass,False,True,462.6,3.68,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.K132N,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.7,0.18,0.329,0.14,0.736,"C132,R158,M160,Y163",Pass,False,True,364.1,4.03,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.K132N,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.683,0.18,0.317,0.139,0.736,"C132,R158,M160,Y163",Pass,False,True,440.3,3.84,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.K132N,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.675,0.18,0.301,0.139,0.736,"C132,R158,M160,Y163",Pass,False,True,422.4,3.59,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.K132N,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.672,0.18,0.303,0.139,0.736,"C132,R158,M160,Y163",Pass,False,True,422.5,3.62,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.K132N,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.631,0.18,0.235,0.139,0.736,"C132,R158,M160,Y163",Pass,False,True,371.8,2.55,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.K132N,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.673,0.18,0.309,0.138,0.736,"C132,R158,M160,Y163",Pass,False,True,454.6,3.71,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.K132N,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.676,0.18,0.322,0.138,0.736,"C132,R158,M160,Y163",Pass,False,True,381.2,3.92,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.K132N,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.624,0.18,0.236,0.138,0.736,"C132,R158,M160,Y163",Pass,False,True,381.7,1.83,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.K132N,WM-TP53-06895,WM-TP53-06895,screening,-3.53,-3.2,0.11,0.0,0.11,0.267,0.204,0.521,0.18,0.435,0.137,0.736,"C132,R158,M160,Y163",Pass,False,True,230.4,0.81,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002573,153
p.K132N,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.666,0.18,0.309,0.137,0.736,"C132,R158,M160,Y163",Pass,False,True,409.9,3.72,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.K132N,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.609,0.18,0.228,0.137,0.736,"C132,R158,M160,Y163",Pass,False,True,465.3,2.42,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.K132N,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.658,0.18,0.298,0.137,0.736,"C132,R158,M160,Y163",Pass,False,False,500.8,1.83,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,156
p.K132N,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.537,0.4,0.408,0.136,0.78,"C132,R158,M160,Y163",Pass,False,True,357.5,-0.03,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.K132N,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.665,0.18,0.329,0.136,0.736,"C132,R158,M160,Y163",Pass,False,True,475.4,4.03,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,158
p.K132N,WM-TP53-06164,WM-TP53-06164,screening,-3.41,-3.2,0.07,0.0,0.07,0.261,0.193,0.592,0.18,0.438,0.135,0.736,"C132,R158,M160,Y163",Pass,False,True,207.4,1.59,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003151,159
p.K132N,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.599,0.18,0.233,0.135,0.736,"C132,R158,M160,Y163",Pass,False,True,476.0,2.52,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.K132N,WM-TP53-04566,WM-TP53-04566,screening,-3.4,-3.2,0.067,0.0,0.067,0.26,0.192,0.584,0.18,0.439,0.134,0.736,"C132,R158,M160,Y163",Pass,False,True,256.3,1.63,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003204,161
p.K132N,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.662,0.18,0.343,0.134,0.736,"C132,R158,M160,Y163",Pass,False,True,441.0,4.25,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.K132N,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.657,0.18,0.343,0.134,0.736,"C132,R158,M160,Y163",Pass,False,True,385.2,3.51,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,163
p.K132N,WM-TP53-02492,WM-TP53-02492,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.193,0.546,0.18,0.419,0.132,0.736,"C132,R158,M160,Y163",Pass,False,True,192.4,1.08,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,164
p.K132N,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.65,0.18,0.349,0.132,0.736,"C132,R158,M160,Y163",Pass,False,True,428.1,4.35,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.K132N,WM-TP53-02407,WM-TP53-02407,screening,-3.53,-3.2,0.11,0.0,0.11,0.267,0.204,0.533,0.18,0.53,0.131,0.736,"C132,R158,M160,Y163",Pass,False,True,257.7,2.54,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002573,166
p.K132N,WM-TP53-02730,WM-TP53-02730,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.188,0.572,0.18,0.414,0.131,0.736,"C132,R158,M160,Y163",Pass,False,True,180.0,0.91,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,167
p.K132N,WM-TP53-05008,WM-TP53-05008,screening,-3.48,-3.2,0.093,0.0,0.093,0.264,0.199,0.528,0.18,0.488,0.129,0.736,"C132,R158,M160,Y163",Pass,False,True,272.0,2.6,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002799,168
p.K132N,WM-TP53-06674,WM-TP53-06674,preclinical,-3.21,-3.2,0.003,0.0,0.003,0.25,0.174,0.517,0.4,0.477,0.129,0.78,"C132,R158,M160,Y163",Pass,False,True,298.4,2.4,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,169
p.K132N,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.624,0.18,0.356,0.129,0.736,"C132,R158,M160,Y163",Pass,False,True,454.4,4.47,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.K132N,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.641,0.18,0.373,0.129,0.736,"C132,R158,M160,Y163",Pass,False,True,485.2,4.05,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.K132N,WM-TP53-05433,WM-TP53-05433,screening,-3.49,-3.2,0.097,0.0,0.097,0.265,0.2,0.504,0.18,0.48,0.128,0.736,"C132,R158,M160,Y163",Pass,False,True,312.1,2.46,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002752,172
p.K132N,WM-TP53-05569,WM-TP53-05569,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.197,0.545,0.18,0.512,0.128,0.736,"C132,R158,M160,Y163",Pass,False,True,275.1,2.99,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,173
p.K132N,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.601,0.18,0.324,0.128,0.736,"C132,R158,M160,Y163",Pass,False,True,373.3,3.22,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.K132N,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.592,0.18,0.317,0.128,0.736,"C132,R158,M160,Y163",Pass,False,True,357.5,3.83,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.K132N,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.629,0.18,0.373,0.128,0.736,"C132,R158,M160,Y163",Pass,False,True,443.5,4.04,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.K132N,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.536,0.4,0.506,0.128,0.78,"C132,R158,M160,Y163",Pass,False,True,299.9,2.9,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.K132N,WM-TP53-05076,WM-TP53-05076,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.188,0.566,0.18,0.452,0.127,0.736,"C132,R158,M160,Y163",Pass,False,True,221.1,1.18,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,178
p.K132N,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.581,0.18,0.307,0.127,0.736,"C132,R158,M160,Y163",Pass,False,True,444.5,3.68,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.K132N,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.506,0.4,0.489,0.126,0.78,"C132,R158,M160,Y163",Pass,False,True,302.3,1.88,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.K132N,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.617,0.18,0.374,0.126,0.736,"C132,R158,M160,Y163",Pass,False,False,523.3,3.18,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.K132N,WM-TP53-08340,WM-TP53-08340,screening,-3.22,-3.2,0.007,0.0,0.007,0.251,0.175,0.614,0.18,0.418,0.124,0.736,"C132,R158,M160,Y163",Pass,False,True,220.2,0.3,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004343,182
p.K132N,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.6,0.18,0.402,0.122,0.736,"C132,R158,M160,Y163",Pass,False,True,316.7,-0.29,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.K132N,WM-TP53-07184,WM-TP53-07184,screening,-3.39,-3.2,0.063,0.0,0.063,0.259,0.191,0.53,0.18,0.496,0.121,0.736,"C132,R158,M160,Y163",Pass,False,True,302.2,2.73,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003259,184
p.K132N,WM-TP53-07116,WM-TP53-07116,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.181,0.558,0.18,0.444,0.121,0.736,"C132,R158,M160,Y163",Pass,False,True,259.1,1.73,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,185
p.K132N,WM-TP53-04107,WM-TP53-04107,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.174,0.594,0.18,0.417,0.121,0.736,"C132,R158,M160,Y163",Pass,False,True,201.4,1.02,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,186
p.K132N,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.587,0.18,0.418,0.119,0.736,"C132,R158,M160,Y163",Pass,False,False,555.5,3.86,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.K132N,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.572,0.18,0.409,0.118,0.736,"C132,R158,M160,Y163",Pass,False,True,360.3,0.74,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.K132N,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.608,0.18,0.459,0.118,0.736,"C132,R158,M160,Y163",Pass,False,True,279.7,1.33,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.K132N,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.555,0.18,0.411,0.116,0.736,"C132,R158,M160,Y163",Pass,False,True,415.1,0.79,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.K132N,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.558,0.18,0.411,0.116,0.736,"C132,R158,M160,Y163",Pass,False,True,287.8,0.82,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.K132N,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.544,0.18,0.411,0.115,0.736,"C132,R158,M160,Y163",Pass,False,True,251.1,0.8,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.K132N,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.556,0.18,0.437,0.114,0.736,"C132,R158,M160,Y163",Pass,False,True,337.7,0.84,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.K132N,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.559,0.18,0.448,0.113,0.736,"C132,R158,M160,Y163",Pass,False,False,516.8,4.33,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.K132N,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.539,0.18,0.46,0.11,0.736,"C132,R158,M160,Y163",Pass,False,True,292.4,2.08,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.K132N,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.532,0.18,0.447,0.11,0.736,"C132,R158,M160,Y163",Pass,False,True,469.0,1.82,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.K132N,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.506,0.18,0.42,0.109,0.736,"C132,R158,M160,Y163",Pass,False,True,473.6,1.11,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.K132N,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.647,0.18,0.634,0.109,0.736,"C132,R158,M160,Y163",Pass,False,True,404.6,4.26,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.K132N,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.53,0.18,0.474,0.108,0.736,"C132,R158,M160,Y163",Pass,False,True,440.0,2.35,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.K132N,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.513,0.18,0.451,0.108,0.736,"C132,R158,M160,Y163",Pass,False,True,349.3,1.17,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.K132N,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.553,0.18,0.524,0.107,0.736,"C132,R158,M160,Y163",Pass,False,True,304.8,3.18,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.K132N,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.528,0.18,0.492,0.106,0.736,"C132,R158,M160,Y163",Pass,False,True,372.6,2.66,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.K132N,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.467,0.18,0.409,0.106,0.736,"C132,R158,M160,Y163",Pass,False,False,517.7,3.71,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.K132N,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.525,0.18,0.49,0.106,0.736,"C132,R158,M160,Y163",Pass,False,True,360.9,2.63,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.K132N,WM-TP53-01693,WM-TP53-01693,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.193,0.538,0.18,0.758,0.104,0.736,"C132,R158,M160,Y163",Pass,False,False,357.0,5.56,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,205
p.K132N,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.503,0.18,0.48,0.104,0.736,"C132,R158,M160,Y163",Pass,False,True,471.5,2.46,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.K132N,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.482,0.18,0.469,0.103,0.736,"C132,R158,M160,Y163",Pass,False,True,388.2,1.52,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.K132N,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.504,0.18,0.504,0.102,0.736,"C132,R158,M160,Y163",Pass,False,True,481.4,2.86,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.K132N,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.509,0.18,0.516,0.102,0.736,"C132,R158,M160,Y163",Pass,False,True,346.3,3.05,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.K132N,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.517,0.18,0.529,0.102,0.736,"C132,R158,M160,Y163",Pass,False,True,319.4,3.26,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.K132N,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.494,0.18,0.489,0.102,0.736,"C132,R158,M160,Y163",Pass,False,True,404.9,2.61,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.K132N,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.508,0.18,0.543,0.1,0.736,"C132,R158,M160,Y163",Pass,False,True,352.2,2.74,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.K132N,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.474,0.18,0.544,0.096,0.736,"C132,R158,M160,Y163",Pass,False,True,365.9,3.48,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.K132N,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.484,0.18,0.557,0.096,0.736,"C132,R158,M160,Y163",Pass,False,True,365.1,3.68,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.K132N,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.469,0.18,0.58,0.092,0.736,"C132,R158,M160,Y163",Pass,False,True,418.1,3.31,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.K132N,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.453,0.18,0.58,0.09,0.736,"C132,R158,M160,Y163",Pass,False,True,485.0,4.04,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.K132N,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.437,0.18,0.57,0.089,0.736,"C132,R158,M160,Y163",Pass,False,True,341.0,3.14,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.K132N,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.537,0.18,0.736,0.088,0.736,"C132,R158,M160,Y163",Pass,False,False,484.5,5.03,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.K132N,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.528,0.18,0.739,0.086,0.736,"C132,R158,M160,Y163",Pass,False,False,463.0,5.1,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.K132N,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.173,0.404,0.18,0.779,0.068,0.636,"C132,R158,M160,Y163",Pass,False,False,477.1,6.2,Docking + MD (benchmark / cavity),DBD (other),Severe liability,Out-of-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.L252P,CTRL-001,PK083,preclinical,-5.59,-3.31,0.76,0.199,0.76,0.473,0.551,0.645,0.8,0.363,0.462,0.86,"C252,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"known-ligand-control,mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,7.9e-05,1
p.L252P,WM-TP53-00860,WM-TP53-00860,preclinical,-5.11,-3.26,0.617,0.139,0.617,0.419,0.407,0.719,0.4,0.292,0.369,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000178,2
p.L252P,WM-TP53-05841,WM-TP53-05841,clinical,-4.7,-3.2,0.5,0.088,0.5,0.373,0.353,0.731,0.62,0.249,0.348,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000356,3
p.L252P,WM-TP53-07201,WM-TP53-07201,screening,-5.24,-3.73,0.503,0.155,0.503,0.411,0.381,0.758,0.18,0.234,0.334,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000143,4
p.L252P,WM-TP53-01421,WM-TP53-01421,screening,-5.05,-3.2,0.617,0.131,0.617,0.415,0.403,0.561,0.18,0.321,0.322,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000197,5
p.L252P,WM-TP53-06487,WM-TP53-06487,screening,-5.0,-3.2,0.6,0.125,0.6,0.409,0.396,0.637,0.18,0.382,0.32,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,302.0,4.96,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000215,6
p.L252P,WM-TP53-00146,WM-TP53-00146,screening,-4.92,-3.39,0.51,0.115,0.51,0.39,0.367,0.769,0.18,0.273,0.319,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000246,7
p.L252P,WM-TP53-00707,WM-TP53-00707,screening,-4.65,-3.2,0.483,0.081,0.483,0.367,0.345,0.792,0.18,0.24,0.306,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000388,8
p.L252P,CTRL-003,PK11000,preclinical,-3.88,-3.2,0.227,0.0,0.227,0.284,0.32,0.854,0.8,0.171,0.3,0.86,"C252,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001424,9
p.L252P,WM-TP53-06028,WM-TP53-06028,screening,-4.82,-3.2,0.54,0.103,0.54,0.387,0.37,0.644,0.18,0.374,0.299,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,292.0,4.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000291,10
p.L252P,WM-TP53-04481,WM-TP53-04481,preclinical,-4.52,-3.2,0.44,0.065,0.44,0.352,0.327,0.711,0.4,0.321,0.295,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,275.4,3.9,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000483,11
p.L252P,WM-TP53-01438,WM-TP53-01438,screening,-4.75,-3.6,0.383,0.094,0.383,0.359,0.322,0.779,0.18,0.212,0.287,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000328,12
p.L252P,WM-TP53-05637,WM-TP53-05637,screening,-4.57,-3.22,0.45,0.071,0.45,0.357,0.332,0.716,0.18,0.26,0.283,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000444,13
p.L252P,WM-TP53-02322,WM-TP53-02322,preclinical,-4.58,-3.78,0.267,0.073,0.267,0.33,0.281,0.812,0.4,0.176,0.28,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000437,14
p.L252P,WM-TP53-01795,WM-TP53-01795,screening,-4.62,-3.25,0.457,0.078,0.457,0.361,0.337,0.61,0.18,0.217,0.278,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000408,15
p.L252P,WM-TP53-05365,WM-TP53-05365,screening,-4.57,-3.2,0.457,0.071,0.457,0.358,0.334,0.694,0.18,0.366,0.274,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,269.4,3.91,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000444,16
p.L252P,WM-TP53-06079,WM-TP53-06079,screening,-4.42,-3.2,0.407,0.052,0.407,0.34,0.312,0.778,0.18,0.257,0.274,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,259.7,2.91,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000572,17
p.L252P,WM-TP53-06555,WM-TP53-06555,screening,-4.5,-3.2,0.433,0.062,0.433,0.349,0.324,0.719,0.18,0.329,0.271,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,265.4,4.03,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.0005,18
p.L252P,WM-TP53-06623,WM-TP53-06623,screening,-4.42,-3.2,0.407,0.052,0.407,0.34,0.312,0.727,0.18,0.242,0.269,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000572,19
p.L252P,WM-TP53-03546,WM-TP53-03546,screening,-4.38,-3.2,0.393,0.047,0.393,0.335,0.306,0.757,0.18,0.272,0.265,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,20
p.L252P,WM-TP53-07949,WM-TP53-07949,approved,-4.02,-3.2,0.273,0.002,0.273,0.292,0.254,0.651,0.72,0.244,0.262,0.844,"C252,R158,M160,Y163,R273,R249",Pass,False,True,255.6,2.69,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001124,21
p.L252P,WM-TP53-02764,WM-TP53-02764,screening,-4.27,-3.2,0.357,0.034,0.357,0.322,0.291,0.781,0.18,0.191,0.26,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,22
p.L252P,WM-TP53-00367,WM-TP53-00367,screening,-4.4,-3.2,0.4,0.05,0.4,0.338,0.309,0.638,0.18,0.228,0.257,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000592,23
p.L252P,WM-TP53-03410,WM-TP53-03410,screening,-4.25,-3.2,0.35,0.031,0.35,0.32,0.288,0.79,0.18,0.229,0.256,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000762,24
p.L252P,WM-TP53-01676,WM-TP53-01676,clinical,-4.03,-3.2,0.277,0.004,0.277,0.294,0.256,0.708,0.62,0.333,0.254,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001106,25
p.L252P,WM-TP53-05280,WM-TP53-05280,screening,-4.55,-3.76,0.263,0.069,0.263,0.327,0.279,0.699,0.18,0.188,0.241,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000459,26
p.L252P,WM-TP53-02798,WM-TP53-02798,screening,-4.15,-3.2,0.317,0.019,0.317,0.308,0.273,0.767,0.18,0.225,0.241,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000903,27
p.L252P,WM-TP53-04600,WM-TP53-04600,screening,-4.06,-3.2,0.287,0.007,0.287,0.297,0.26,0.791,0.18,0.204,0.234,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001051,28
p.L252P,WM-TP53-05977,WM-TP53-05977,screening,-4.17,-3.2,0.323,0.021,0.323,0.31,0.276,0.705,0.18,0.266,0.232,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,301.7,3.06,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,29
p.L252P,CTRL-002,PK7088,preclinical,-3.87,-3.2,0.223,0.0,0.223,0.283,0.319,0.609,0.8,0.653,0.231,0.86,"C252,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,30
p.L252P,WM-TP53-04056,WM-TP53-04056,screening,-4.01,-3.2,0.27,0.001,0.27,0.291,0.253,0.798,0.18,0.198,0.229,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,244.9,1.84,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001144,31
p.L252P,WM-TP53-05331,WM-TP53-05331,screening,-4.1,-3.2,0.3,0.012,0.3,0.302,0.266,0.688,0.18,0.222,0.225,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,246.1,2.31,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000982,32
p.L252P,WM-TP53-06249,WM-TP53-06249,screening,-4.01,-3.2,0.27,0.001,0.27,0.291,0.253,0.76,0.18,0.217,0.223,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,273.1,2.22,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001144,33
p.L252P,WM-TP53-07575,WM-TP53-07575,preclinical,-3.77,-3.2,0.19,0.0,0.19,0.278,0.23,0.786,0.4,0.275,0.223,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,299.7,3.2,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,34
p.L252P,WM-TP53-06810,WM-TP53-06810,clinical,-4.09,-3.2,0.297,0.011,0.297,0.301,0.265,0.508,0.62,0.543,0.221,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000999,35
p.L252P,WM-TP53-08000,WM-TP53-08000,screening,-4.06,-3.2,0.287,0.007,0.287,0.297,0.26,0.688,0.18,0.224,0.22,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001051,36
p.L252P,WM-TP53-07609,WM-TP53-07609,screening,-4.0,-3.2,0.267,0.0,0.267,0.29,0.252,0.763,0.18,0.245,0.22,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,275.3,2.72,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001163,37
p.L252P,WM-TP53-02475,WM-TP53-02475,screening,-4.03,-3.2,0.277,0.004,0.277,0.294,0.256,0.756,0.18,0.292,0.219,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001106,38
p.L252P,WM-TP53-04923,WM-TP53-04923,preclinical,-3.77,-3.2,0.19,0.0,0.19,0.278,0.23,0.735,0.4,0.252,0.219,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,273.1,2.83,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,39
p.L252P,WM-TP53-03988,WM-TP53-03988,screening,-4.3,-3.2,0.367,0.037,0.367,0.326,0.295,0.555,0.18,0.463,0.215,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000701,40
p.L252P,WM-TP53-04991,WM-TP53-04991,screening,-4.02,-3.2,0.273,0.002,0.273,0.292,0.254,0.68,0.18,0.202,0.215,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001124,41
p.L252P,WM-TP53-05501,WM-TP53-05501,clinical,-3.28,-3.2,0.027,0.0,0.027,0.254,0.184,0.799,0.62,0.231,0.211,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,297.2,2.47,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,42
p.L252P,WM-TP53-05586,WM-TP53-05586,screening,-4.09,-3.42,0.223,0.011,0.223,0.29,0.244,0.688,0.18,0.172,0.21,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000999,43
p.L252P,WM-TP53-02305,WM-TP53-02305,screening,-4.08,-3.2,0.293,0.01,0.293,0.299,0.263,0.668,0.18,0.35,0.21,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001016,44
p.L252P,WM-TP53-06997,WM-TP53-06997,screening,-3.96,-3.2,0.253,0.0,0.253,0.288,0.248,0.703,0.18,0.237,0.21,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,258.1,2.58,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001244,45
p.L252P,WM-TP53-03172,WM-TP53-03172,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.23,0.797,0.18,0.189,0.209,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,46
p.L252P,WM-TP53-01217,WM-TP53-01217,screening,-4.71,-3.83,0.293,0.089,0.293,0.343,0.295,0.509,0.18,0.491,0.208,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000351,47
p.L252P,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.257,0.599,0.88,0.388,0.205,0.876,"C252,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.L252P,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.807,0.62,0.228,0.205,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,49
p.L252P,WM-TP53-05926,WM-TP53-05926,screening,-3.94,-3.2,0.247,0.0,0.247,0.287,0.246,0.66,0.18,0.224,0.204,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,246.6,2.35,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001287,50
p.L252P,WM-TP53-06538,WM-TP53-06538,screening,-3.82,-3.2,0.207,0.0,0.207,0.281,0.235,0.742,0.18,0.222,0.204,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,246.6,2.32,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001576,51
p.L252P,WM-TP53-01625,WM-TP53-01625,screening,-3.86,-3.2,0.22,0.0,0.22,0.283,0.238,0.694,0.18,0.212,0.203,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001473,52
p.L252P,WM-TP53-00214,WM-TP53-00214,screening,-3.84,-3.2,0.213,0.0,0.213,0.282,0.236,0.742,0.18,0.267,0.202,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001524,53
p.L252P,WM-TP53-02526,WM-TP53-02526,screening,-4.63,-3.8,0.277,0.079,0.277,0.335,0.287,0.505,0.18,0.495,0.2,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000401,54
p.L252P,WM-TP53-07048,WM-TP53-07048,screening,-4.13,-3.2,0.31,0.016,0.31,0.305,0.27,0.592,0.18,0.433,0.2,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000934,55
p.L252P,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.781,0.62,0.256,0.2,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.L252P,WM-TP53-04294,WM-TP53-04294,screening,-3.64,-3.2,0.147,0.0,0.147,0.272,0.218,0.801,0.18,0.201,0.199,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,251.6,1.9,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002136,57
p.L252P,WM-TP53-03121,WM-TP53-03121,screening,-3.88,-3.2,0.227,0.0,0.227,0.284,0.24,0.687,0.18,0.295,0.197,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001424,58
p.L252P,WM-TP53-05416,WM-TP53-05416,screening,-3.93,-3.2,0.243,0.0,0.243,0.286,0.245,0.666,0.18,0.328,0.195,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,329.0,4.0,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001309,59
p.L252P,WM-TP53-01982,WM-TP53-01982,screening,-3.59,-3.2,0.13,0.0,0.13,0.27,0.213,0.785,0.18,0.179,0.194,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002325,60
p.L252P,WM-TP53-02951,WM-TP53-02951,screening,-3.87,-3.2,0.223,0.0,0.223,0.283,0.239,0.681,0.18,0.334,0.192,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,61
p.L252P,WM-TP53-03444,WM-TP53-03444,screening,-3.85,-3.2,0.217,0.0,0.217,0.283,0.238,0.681,0.18,0.33,0.191,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,310.9,3.31,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,62
p.L252P,WM-TP53-06521,WM-TP53-06521,clinical,-3.48,-3.2,0.093,0.0,0.093,0.264,0.203,0.563,0.62,0.33,0.191,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,302.6,3.3,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002799,63
p.L252P,WM-TP53-06589,WM-TP53-06589,screening,-4.13,-3.2,0.31,0.016,0.31,0.305,0.27,0.547,0.18,0.506,0.189,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,256.5,2.89,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000934,64
p.L252P,WM-TP53-06232,WM-TP53-06232,preclinical,-3.33,-3.2,0.043,0.0,0.043,0.256,0.189,0.759,0.4,0.226,0.188,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,281.9,1.65,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003607,65
p.L252P,WM-TP53-05705,WM-TP53-05705,screening,-4.1,-3.31,0.263,0.012,0.263,0.296,0.256,0.601,0.18,0.452,0.187,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000982,66
p.L252P,WM-TP53-05246,WM-TP53-05246,preclinical,-3.91,-3.22,0.23,0.0,0.23,0.284,0.241,0.507,0.4,0.436,0.187,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001354,67
p.L252P,WM-TP53-06198,WM-TP53-06198,screening,-3.61,-3.2,0.137,0.0,0.137,0.271,0.215,0.752,0.18,0.249,0.186,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,306.3,2.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002247,68
p.L252P,WM-TP53-02747,WM-TP53-02747,preclinical,-3.49,-3.2,0.097,0.0,0.097,0.265,0.204,0.651,0.4,0.256,0.186,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002752,69
p.L252P,WM-TP53-01727,WM-TP53-01727,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.201,0.812,0.18,0.209,0.185,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,70
p.L252P,WM-TP53-03376,WM-TP53-03376,screening,-3.45,-3.2,0.083,0.0,0.083,0.262,0.2,0.791,0.18,0.174,0.184,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,230.4,1.24,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002945,71
p.L252P,WM-TP53-04090,WM-TP53-04090,screening,-3.85,-3.2,0.217,0.0,0.217,0.283,0.238,0.593,0.18,0.328,0.181,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,308.3,4.01,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,72
p.L252P,WM-TP53-05518,WM-TP53-05518,clinical,-3.53,-3.2,0.11,0.0,0.11,0.267,0.208,0.518,0.62,0.429,0.181,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,244.4,1.37,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002573,73
p.L252P,WM-TP53-04430,WM-TP53-04430,preclinical,-3.43,-3.2,0.077,0.0,0.077,0.262,0.198,0.696,0.4,0.325,0.181,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,337.5,3.96,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,74
p.L252P,WM-TP53-07898,WM-TP53-07898,screening,-4.08,-3.2,0.293,0.01,0.293,0.299,0.263,0.529,0.18,0.512,0.18,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,293.4,2.99,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001016,75
p.L252P,WM-TP53-03087,WM-TP53-03087,screening,-3.97,-3.2,0.257,0.0,0.257,0.289,0.249,0.59,0.18,0.486,0.177,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001223,76
p.L252P,WM-TP53-01064,WM-TP53-01064,screening,-3.44,-3.2,0.08,0.0,0.08,0.262,0.199,0.776,0.18,0.234,0.177,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002995,77
p.L252P,WM-TP53-05671,WM-TP53-05671,screening,-3.96,-3.2,0.253,0.0,0.253,0.288,0.248,0.577,0.18,0.482,0.175,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.49,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001244,78
p.L252P,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.61,0.62,0.315,0.175,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.L252P,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.696,0.4,0.189,0.173,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.L252P,WM-TP53-04583,WM-TP53-04583,screening,-3.57,-3.2,0.123,0.0,0.123,0.268,0.211,0.657,0.18,0.238,0.172,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,265.7,1.87,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002405,81
p.L252P,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.695,0.4,0.206,0.172,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.L252P,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.694,0.4,0.203,0.172,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.L252P,WM-TP53-04260,WM-TP53-04260,screening,-3.51,-3.2,0.103,0.0,0.103,0.265,0.206,0.719,0.18,0.288,0.171,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,319.5,3.4,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002661,84
p.L252P,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.736,0.4,0.272,0.171,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.L252P,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.728,0.4,0.262,0.171,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.L252P,WM-TP53-07286,WM-TP53-07286,screening,-3.98,-3.2,0.26,0.0,0.26,0.289,0.25,0.626,0.18,0.634,0.17,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,351.2,4.99,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001203,87
p.L252P,WM-TP53-05739,WM-TP53-05739,screening,-3.86,-3.2,0.22,0.0,0.22,0.283,0.238,0.575,0.18,0.434,0.17,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001473,88
p.L252P,WM-TP53-06351,WM-TP53-06351,screening,-3.6,-3.2,0.133,0.0,0.133,0.27,0.214,0.643,0.18,0.282,0.17,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,294.4,2.57,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002286,89
p.L252P,WM-TP53-01353,WM-TP53-01353,screening,-3.37,-3.2,0.057,0.0,0.057,0.259,0.193,0.775,0.18,0.264,0.169,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003371,90
p.L252P,WM-TP53-03648,WM-TP53-03648,screening,-3.37,-3.2,0.057,0.0,0.057,0.259,0.193,0.758,0.18,0.233,0.169,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,282.1,2.51,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003371,91
p.L252P,WM-TP53-06402,WM-TP53-06402,screening,-3.87,-3.32,0.183,0.0,0.183,0.277,0.228,0.615,0.18,0.418,0.168,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,92
p.L252P,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.821,0.18,0.182,0.167,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.L252P,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.565,0.62,0.339,0.167,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.L252P,WM-TP53-01472,WM-TP53-01472,screening,-3.94,-3.2,0.247,0.0,0.247,0.287,0.246,0.522,0.18,0.496,0.166,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001287,95
p.L252P,WM-TP53-04073,WM-TP53-04073,screening,-3.51,-3.2,0.103,0.0,0.103,0.265,0.206,0.646,0.18,0.235,0.166,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,273.9,2.55,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002661,96
p.L252P,WM-TP53-06572,WM-TP53-06572,screening,-3.39,-3.2,0.063,0.0,0.063,0.259,0.194,0.746,0.18,0.269,0.166,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,281.5,2.37,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003259,97
p.L252P,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.797,0.18,0.171,0.165,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.L252P,WM-TP53-00299,WM-TP53-00299,screening,-3.83,-3.2,0.21,0.0,0.21,0.281,0.236,0.581,0.18,0.488,0.164,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00155,99
p.L252P,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.804,0.18,0.197,0.164,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.L252P,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.785,0.18,0.159,0.164,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,101
p.L252P,WM-TP53-03223,WM-TP53-03223,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.23,0.597,0.18,0.464,0.163,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,102
p.L252P,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.579,0.62,0.419,0.163,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.L252P,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.698,0.4,0.315,0.163,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.L252P,WM-TP53-05093,WM-TP53-05093,screening,-3.83,-3.2,0.21,0.0,0.21,0.281,0.236,0.523,0.18,0.447,0.161,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00155,105
p.L252P,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.754,0.18,0.159,0.161,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.L252P,WM-TP53-01965,WM-TP53-01965,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.19,0.727,0.18,0.268,0.16,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,107
p.L252P,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.756,0.18,0.168,0.16,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.L252P,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.767,0.18,0.19,0.16,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.L252P,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.677,0.4,0.34,0.159,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.L252P,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.591,0.4,0.221,0.158,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.L252P,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.528,0.62,0.412,0.157,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.L252P,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.546,0.62,0.455,0.156,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.L252P,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.721,0.18,0.178,0.155,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Docking + MD (benchmark / cavity),DBD (other),Acceptable,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.L252P,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.743,0.18,0.215,0.155,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.L252P,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.75,0.18,0.221,0.155,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.L252P,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.706,0.18,0.17,0.154,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.L252P,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.633,0.4,0.339,0.154,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.L252P,WM-TP53-02186,WM-TP53-02186,screening,-3.51,-3.2,0.103,0.0,0.103,0.265,0.206,0.631,0.18,0.376,0.153,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002661,119
p.L252P,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.73,0.18,0.221,0.153,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.L252P,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.734,0.18,0.227,0.153,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.L252P,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.754,0.18,0.248,0.153,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.L252P,WM-TP53-05161,WM-TP53-05161,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.182,0.721,0.18,0.273,0.152,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,318.3,3.17,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,123
p.L252P,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.735,0.18,0.231,0.152,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.L252P,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.733,0.18,0.231,0.152,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.L252P,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.746,0.18,0.249,0.152,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.L252P,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.764,0.18,0.286,0.152,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.L252P,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.731,0.18,0.244,0.151,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.L252P,WM-TP53-00231,WM-TP53-00231,screening,-3.72,-3.2,0.173,0.0,0.173,0.276,0.225,0.557,0.18,0.521,0.15,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001866,129
p.L252P,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.494,0.62,0.45,0.15,0.824,"C252,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.L252P,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.716,0.18,0.249,0.149,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.L252P,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.686,0.18,0.196,0.149,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.L252P,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.724,0.18,0.275,0.148,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.L252P,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.69,0.18,0.223,0.148,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.L252P,WM-TP53-02917,WM-TP53-02917,screening,-3.61,-3.2,0.137,0.0,0.137,0.271,0.215,0.554,0.18,0.444,0.147,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002247,135
p.L252P,WM-TP53-05790,WM-TP53-05790,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.18,0.694,0.18,0.273,0.147,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,333.7,2.43,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,136
p.L252P,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.712,0.18,0.272,0.146,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.L252P,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.721,0.18,0.288,0.146,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.L252P,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.598,0.4,0.377,0.146,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.L252P,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.709,0.18,0.289,0.145,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.L252P,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.705,0.18,0.293,0.144,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.L252P,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.706,0.18,0.31,0.143,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.L252P,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.686,0.18,0.307,0.141,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,143
p.L252P,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.679,0.18,0.301,0.14,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.L252P,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.675,0.18,0.301,0.14,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.L252P,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.7,0.18,0.329,0.14,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.L252P,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.631,0.18,0.235,0.14,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.L252P,WM-TP53-06895,WM-TP53-06895,screening,-3.55,-3.2,0.117,0.0,0.117,0.268,0.21,0.521,0.18,0.435,0.139,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,230.4,0.81,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002487,148
p.L252P,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.673,0.18,0.309,0.139,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.L252P,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.683,0.18,0.317,0.139,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.L252P,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.624,0.18,0.236,0.139,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.L252P,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.672,0.18,0.303,0.139,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.L252P,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.666,0.18,0.309,0.138,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.L252P,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.676,0.18,0.322,0.138,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.L252P,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.609,0.18,0.228,0.138,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.L252P,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.658,0.18,0.298,0.138,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,156
p.L252P,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.537,0.4,0.408,0.137,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.L252P,WM-TP53-04566,WM-TP53-04566,screening,-3.43,-3.2,0.077,0.0,0.077,0.262,0.198,0.584,0.18,0.439,0.136,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,256.3,1.63,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,158
p.L252P,WM-TP53-06164,WM-TP53-06164,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.197,0.592,0.18,0.438,0.136,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,207.4,1.59,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,159
p.L252P,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.599,0.18,0.233,0.136,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.L252P,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.665,0.18,0.329,0.136,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,161
p.L252P,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.662,0.18,0.343,0.135,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.L252P,WM-TP53-02492,WM-TP53-02492,screening,-3.43,-3.2,0.077,0.0,0.077,0.262,0.198,0.546,0.18,0.419,0.134,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,163
p.L252P,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.657,0.18,0.343,0.134,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.L252P,WM-TP53-02407,WM-TP53-02407,screening,-3.56,-3.2,0.12,0.0,0.12,0.268,0.21,0.533,0.18,0.53,0.133,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002445,165
p.L252P,WM-TP53-05008,WM-TP53-05008,screening,-3.52,-3.2,0.107,0.0,0.107,0.266,0.207,0.528,0.18,0.488,0.133,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,272.0,2.6,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002616,166
p.L252P,WM-TP53-06674,WM-TP53-06674,preclinical,-3.26,-3.2,0.02,0.0,0.02,0.253,0.182,0.517,0.4,0.477,0.133,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,298.4,2.4,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,167
p.L252P,WM-TP53-05433,WM-TP53-05433,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.208,0.504,0.18,0.48,0.132,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,312.1,2.46,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,168
p.L252P,WM-TP53-05569,WM-TP53-05569,screening,-3.49,-3.2,0.097,0.0,0.097,0.265,0.204,0.545,0.18,0.512,0.131,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,275.1,2.99,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002752,169
p.L252P,WM-TP53-02730,WM-TP53-02730,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.192,0.572,0.18,0.414,0.131,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,170
p.L252P,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.641,0.18,0.373,0.13,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.L252P,WM-TP53-05076,WM-TP53-05076,screening,-3.38,-3.2,0.06,0.0,0.06,0.259,0.194,0.566,0.18,0.452,0.129,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,221.1,1.18,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003314,172
p.L252P,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.601,0.18,0.324,0.129,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.L252P,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.624,0.18,0.356,0.129,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.L252P,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.536,0.4,0.506,0.129,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.L252P,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.581,0.18,0.307,0.128,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.L252P,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.592,0.18,0.317,0.128,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.L252P,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.629,0.18,0.373,0.128,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.L252P,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.617,0.18,0.374,0.127,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.L252P,WM-TP53-07184,WM-TP53-07184,screening,-3.44,-3.2,0.08,0.0,0.08,0.262,0.199,0.53,0.18,0.496,0.126,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,302.2,2.73,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002995,180
p.L252P,WM-TP53-08340,WM-TP53-08340,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.18,0.614,0.18,0.418,0.126,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,220.2,0.3,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,181
p.L252P,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.506,0.4,0.489,0.126,0.78,"C252,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.L252P,WM-TP53-07116,WM-TP53-07116,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.188,0.558,0.18,0.444,0.124,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,259.1,1.73,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,183
p.L252P,WM-TP53-04107,WM-TP53-04107,screening,-3.23,-3.2,0.01,0.0,0.01,0.252,0.18,0.594,0.18,0.417,0.123,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,201.4,1.02,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00427,184
p.L252P,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.6,0.18,0.402,0.123,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.L252P,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.587,0.18,0.418,0.12,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.L252P,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.572,0.18,0.409,0.119,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.L252P,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.608,0.18,0.459,0.119,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.L252P,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.558,0.18,0.411,0.117,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.L252P,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.555,0.18,0.411,0.116,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.L252P,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.556,0.18,0.437,0.115,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.L252P,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.544,0.18,0.411,0.115,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.L252P,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.559,0.18,0.448,0.114,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.L252P,WM-TP53-01693,WM-TP53-01693,screening,-3.5,-3.2,0.1,0.0,0.1,0.265,0.205,0.538,0.18,0.758,0.111,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002706,194
p.L252P,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.539,0.18,0.46,0.111,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.L252P,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.532,0.18,0.447,0.111,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.L252P,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.506,0.18,0.42,0.11,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.L252P,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.647,0.18,0.634,0.11,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.L252P,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.53,0.18,0.474,0.108,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.L252P,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.513,0.18,0.451,0.108,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.L252P,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.528,0.18,0.492,0.107,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.L252P,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.525,0.18,0.49,0.107,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.L252P,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.553,0.18,0.524,0.107,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.L252P,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.467,0.18,0.409,0.106,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Docking + MD (benchmark / cavity),DBD (other),Watch,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.L252P,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.503,0.18,0.48,0.105,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.L252P,WM-TP53-02679,WM-TP53-02679,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.18,0.508,0.18,0.538,0.104,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,206
p.L252P,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.482,0.18,0.469,0.103,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.L252P,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.504,0.18,0.504,0.103,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.L252P,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.509,0.18,0.516,0.103,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.L252P,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.494,0.18,0.489,0.103,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.L252P,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.517,0.18,0.529,0.102,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.L252P,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.508,0.18,0.543,0.1,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.L252P,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.474,0.18,0.544,0.096,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.L252P,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.484,0.18,0.557,0.096,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.L252P,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.469,0.18,0.58,0.093,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.L252P,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.453,0.18,0.58,0.091,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.L252P,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.437,0.18,0.57,0.09,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.L252P,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.537,0.18,0.736,0.088,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.L252P,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.528,0.18,0.739,0.087,0.736,"C252,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Docking + MD (benchmark / cavity),DBD (other),Severe liability,In-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.L252P,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.404,0.18,0.779,0.069,0.636,"C252,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Docking + MD (benchmark / cavity),DBD (other),Severe liability,Out-of-domain,Putative mutation-enlarged pocket; test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.P152L,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.86,"C152,R158,M160,Y163",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.P152L,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.86,"C152,R158,M160,Y163",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.P152L,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.78,"C152,R158,M160,Y163",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.P152L,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.78,"C152,R158,M160,Y163",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.P152L,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.824,"C152,R158,M160,Y163",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.P152L,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.736,"C152,R158,M160,Y163",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.P152L,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.736,"C152,R158,M160,Y163",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.P152L,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.736,"C152,R158,M160,Y163",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.P152L,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.736,"C152,R158,M160,Y163",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.P152L,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.876,"C152,R158,M160,Y163",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.P152L,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.736,"C152,R158,M160,Y163",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.P152L,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.736,"C152,R158,M160,Y163",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.P152L,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.824,"C152,R158,M160,Y163",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.P152L,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.824,"C152,R158,M160,Y163",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.P152L,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.736,"C152,R158,M160,Y163",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.P152L,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.824,"C152,R158,M160,Y163",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.P152L,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.736,"C152,R158,M160,Y163",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.P152L,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.736,"C152,R158,M160,Y163",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.P152L,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.824,"C152,R158,M160,Y163",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.P152L,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.736,"C152,R158,M160,Y163",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.P152L,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.824,"C152,R158,M160,Y163",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.P152L,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.736,"C152,R158,M160,Y163",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.P152L,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.824,"C152,R158,M160,Y163",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.P152L,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.78,"C152,R158,M160,Y163",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.P152L,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.86,"C152,R158,M160,Y163",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.P152L,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.736,"C152,R158,M160,Y163",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.P152L,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.824,"C152,R158,M160,Y163",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.P152L,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.78,"C152,R158,M160,Y163",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.P152L,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.78,"C152,R158,M160,Y163",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.P152L,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.78,"C152,R158,M160,Y163",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.P152L,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.736,"C152,R158,M160,Y163",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.P152L,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.78,"C152,R158,M160,Y163",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.P152L,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.78,"C152,R158,M160,Y163",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.P152L,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.78,"C152,R158,M160,Y163",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.P152L,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.736,"C152,R158,M160,Y163",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.P152L,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.78,"C152,R158,M160,Y163",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.P152L,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.824,"C152,R158,M160,Y163",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.P152L,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.824,"C152,R158,M160,Y163",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.P152L,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.736,"C152,R158,M160,Y163",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.P152L,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.736,"C152,R158,M160,Y163",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.P152L,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.736,"C152,R158,M160,Y163",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.P152L,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.736,"C152,R158,M160,Y163",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.P152L,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.78,"C152,R158,M160,Y163",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.P152L,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.736,"C152,R158,M160,Y163",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.P152L,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.736,"C152,R158,M160,Y163",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.P152L,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.78,"C152,R158,M160,Y163",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.P152L,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.736,"C152,R158,M160,Y163",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.P152L,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.736,"C152,R158,M160,Y163",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.P152L,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.736,"C152,R158,M160,Y163",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.P152L,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.824,"C152,R158,M160,Y163",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.P152L,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.736,"C152,R158,M160,Y163",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.P152L,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.78,"C152,R158,M160,Y163",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.P152L,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.736,"C152,R158,M160,Y163",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.P152L,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.736,"C152,R158,M160,Y163",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.P152L,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.736,"C152,R158,M160,Y163",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.P152L,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.78,"C152,R158,M160,Y163",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.P152L,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.736,"C152,R158,M160,Y163",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.P152L,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.736,"C152,R158,M160,Y163",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.P152L,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.78,"C152,R158,M160,Y163",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.P152L,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.736,"C152,R158,M160,Y163",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.P152L,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.736,"C152,R158,M160,Y163",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.P152L,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.736,"C152,R158,M160,Y163",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.P152L,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.824,"C152,R158,M160,Y163",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.P152L,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.736,"C152,R158,M160,Y163",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.P152L,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.824,"C152,R158,M160,Y163",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.P152L,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.736,"C152,R158,M160,Y163",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.P152L,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.736,"C152,R158,M160,Y163",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.P152L,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.736,"C152,R158,M160,Y163",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.P152L,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.736,"C152,R158,M160,Y163",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.P152L,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.736,"C152,R158,M160,Y163",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.P152L,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.736,"C152,R158,M160,Y163",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.P152L,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.736,"C152,R158,M160,Y163",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.P152L,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.78,"C152,R158,M160,Y163",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.P152L,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.736,"C152,R158,M160,Y163",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.P152L,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.78,"C152,R158,M160,Y163",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.P152L,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.736,"C152,R158,M160,Y163",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.P152L,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.736,"C152,R158,M160,Y163",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.P152L,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.736,"C152,R158,M160,Y163",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.P152L,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.736,"C152,R158,M160,Y163",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.P152L,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.736,"C152,R158,M160,Y163",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.P152L,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.736,"C152,R158,M160,Y163",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.P152L,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.736,"C152,R158,M160,Y163",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.P152L,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.736,"C152,R158,M160,Y163",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.P152L,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.736,"C152,R158,M160,Y163",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.P152L,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.736,"C152,R158,M160,Y163",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.P152L,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.736,"C152,R158,M160,Y163",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.P152L,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.736,"C152,R158,M160,Y163",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.P152L,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.736,"C152,R158,M160,Y163",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.P152L,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.736,"C152,R158,M160,Y163",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.P152L,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.736,"C152,R158,M160,Y163",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.P152L,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.824,"C152,R158,M160,Y163",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.P152L,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.736,"C152,R158,M160,Y163",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.P152L,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.736,"C152,R158,M160,Y163",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.P152L,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.736,"C152,R158,M160,Y163",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.P152L,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.736,"C152,R158,M160,Y163",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.P152L,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.736,"C152,R158,M160,Y163",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.P152L,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.736,"C152,R158,M160,Y163",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.P152L,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.736,"C152,R158,M160,Y163",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.P152L,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.736,"C152,R158,M160,Y163",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.P152L,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.736,"C152,R158,M160,Y163",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.P152L,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.736,"C152,R158,M160,Y163",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.P152L,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.736,"C152,R158,M160,Y163",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.P152L,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.736,"C152,R158,M160,Y163",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.P152L,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.78,"C152,R158,M160,Y163",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.P152L,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.736,"C152,R158,M160,Y163",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.P152L,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.736,"C152,R158,M160,Y163",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.P152L,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.736,"C152,R158,M160,Y163",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.P152L,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.736,"C152,R158,M160,Y163",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.P152L,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.736,"C152,R158,M160,Y163",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.P152L,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.736,"C152,R158,M160,Y163",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.P152L,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.736,"C152,R158,M160,Y163",Pass,False,True,429.0,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.P152L,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.736,"C152,R158,M160,Y163",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.P152L,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.736,"C152,R158,M160,Y163",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.P152L,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.736,"C152,R158,M160,Y163",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.P152L,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.736,"C152,R158,M160,Y163",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.P152L,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.736,"C152,R158,M160,Y163",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.P152L,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.736,"C152,R158,M160,Y163",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.P152L,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.736,"C152,R158,M160,Y163",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.P152L,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.736,"C152,R158,M160,Y163",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.P152L,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.78,"C152,R158,M160,Y163",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.P152L,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.736,"C152,R158,M160,Y163",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.P152L,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.736,"C152,R158,M160,Y163",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.P152L,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.736,"C152,R158,M160,Y163",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.P152L,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.736,"C152,R158,M160,Y163",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.P152L,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.736,"C152,R158,M160,Y163",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.P152L,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.736,"C152,R158,M160,Y163",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.P152L,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.736,"C152,R158,M160,Y163",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.P152L,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.736,"C152,R158,M160,Y163",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.P152L,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.736,"C152,R158,M160,Y163",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.P152L,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.78,"C152,R158,M160,Y163",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.P152L,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.736,"C152,R158,M160,Y163",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.P152L,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.736,"C152,R158,M160,Y163",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.P152L,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.78,"C152,R158,M160,Y163",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.P152L,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.736,"C152,R158,M160,Y163",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.P152L,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.736,"C152,R158,M160,Y163",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.P152L,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.736,"C152,R158,M160,Y163",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.P152L,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.736,"C152,R158,M160,Y163",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.P152L,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.736,"C152,R158,M160,Y163",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.P152L,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.736,"C152,R158,M160,Y163",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.P152L,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.736,"C152,R158,M160,Y163",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.P152L,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.736,"C152,R158,M160,Y163",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.P152L,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.736,"C152,R158,M160,Y163",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.P152L,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.736,"C152,R158,M160,Y163",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.P152L,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.736,"C152,R158,M160,Y163",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.P152L,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.736,"C152,R158,M160,Y163",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.P152L,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.736,"C152,R158,M160,Y163",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.P152L,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.736,"C152,R158,M160,Y163",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.P152L,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.736,"C152,R158,M160,Y163",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.P152L,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.736,"C152,R158,M160,Y163",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.P152L,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.736,"C152,R158,M160,Y163",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.P152L,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.736,"C152,R158,M160,Y163",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.P152L,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.78,"C152,R158,M160,Y163",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.P152L,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.736,"C152,R158,M160,Y163",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.P152L,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.736,"C152,R158,M160,Y163",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.P152L,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.78,"C152,R158,M160,Y163",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.P152L,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.736,"C152,R158,M160,Y163",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.P152L,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.736,"C152,R158,M160,Y163",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.P152L,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.736,"C152,R158,M160,Y163",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.P152L,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.736,"C152,R158,M160,Y163",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.P152L,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.736,"C152,R158,M160,Y163",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.P152L,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.736,"C152,R158,M160,Y163",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.P152L,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.736,"C152,R158,M160,Y163",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.P152L,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.736,"C152,R158,M160,Y163",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.P152L,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.736,"C152,R158,M160,Y163",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.P152L,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.736,"C152,R158,M160,Y163",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.P152L,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.736,"C152,R158,M160,Y163",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.P152L,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.736,"C152,R158,M160,Y163",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.P152L,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.736,"C152,R158,M160,Y163",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.P152L,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.736,"C152,R158,M160,Y163",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.P152L,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.736,"C152,R158,M160,Y163",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.P152L,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.736,"C152,R158,M160,Y163",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.P152L,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.736,"C152,R158,M160,Y163",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.P152L,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.736,"C152,R158,M160,Y163",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.P152L,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.736,"C152,R158,M160,Y163",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.P152L,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.736,"C152,R158,M160,Y163",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.P152L,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.736,"C152,R158,M160,Y163",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.P152L,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.736,"C152,R158,M160,Y163",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.P152L,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.736,"C152,R158,M160,Y163",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.P152L,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.736,"C152,R158,M160,Y163",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.P152L,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.736,"C152,R158,M160,Y163",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.P152L,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.736,"C152,R158,M160,Y163",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.P152L,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.736,"C152,R158,M160,Y163",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.P152L,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.736,"C152,R158,M160,Y163",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.P152L,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.736,"C152,R158,M160,Y163",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.P152L,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.736,"C152,R158,M160,Y163",Pass,False,False,552.3,4.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.P152L,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.736,"C152,R158,M160,Y163",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.P152L,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.736,"C152,R158,M160,Y163",Pass,False,True,404.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.P152L,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.736,"C152,R158,M160,Y163",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.P152L,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.736,"C152,R158,M160,Y163",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.P152L,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.736,"C152,R158,M160,Y163",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.P152L,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.736,"C152,R158,M160,Y163",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.P152L,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.736,"C152,R158,M160,Y163",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.P152L,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.736,"C152,R158,M160,Y163",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.P152L,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.736,"C152,R158,M160,Y163",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.P152L,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.736,"C152,R158,M160,Y163",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.P152L,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.736,"C152,R158,M160,Y163",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.P152L,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.736,"C152,R158,M160,Y163",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.P152L,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.736,"C152,R158,M160,Y163",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.P152L,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.736,"C152,R158,M160,Y163",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.P152L,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.736,"C152,R158,M160,Y163",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.P152L,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.736,"C152,R158,M160,Y163",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.P152L,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.736,"C152,R158,M160,Y163",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.P152L,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.736,"C152,R158,M160,Y163",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.P152L,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.736,"C152,R158,M160,Y163",Pass,False,True,404.0,2.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.P152L,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.736,"C152,R158,M160,Y163",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.P152L,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.736,"C152,R158,M160,Y163",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.P152L,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.736,"C152,R158,M160,Y163",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.P152L,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.736,"C152,R158,M160,Y163",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.P152L,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.736,"C152,R158,M160,Y163",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.P152L,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.736,"C152,R158,M160,Y163",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.P152L,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.736,"C152,R158,M160,Y163",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.P152L,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.736,"C152,R158,M160,Y163",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.P152L,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.736,"C152,R158,M160,Y163",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.P152L,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.736,"C152,R158,M160,Y163",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.P152L,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.736,"C152,R158,M160,Y163",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.P152L,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.736,"C152,R158,M160,Y163",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.P152L,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.736,"C152,R158,M160,Y163",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.P152L,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.736,"C152,R158,M160,Y163",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.P152L,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.736,"C152,R158,M160,Y163",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.P152L,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.636,"C152,R158,M160,Y163",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.P278S,CTRL-001,PK083,preclinical,-4.41,-3.31,0.367,0.051,0.367,0.333,0.287,0.645,0.8,0.363,0.299,0.86,"C278,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000582,1
p.P278S,WM-TP53-00860,WM-TP53-00860,preclinical,-4.2,-3.26,0.313,0.025,0.313,0.311,0.181,0.719,0.4,0.292,0.24,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00083,2
p.P278S,CTRL-003,PK11000,preclinical,-3.25,-3.2,0.017,0.0,0.017,0.253,0.168,0.854,0.8,0.171,0.236,0.86,"C278,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,3
p.P278S,WM-TP53-02322,WM-TP53-02322,preclinical,-4.32,-3.78,0.18,0.04,0.18,0.299,0.15,0.812,0.4,0.176,0.233,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,4
p.P278S,WM-TP53-05841,WM-TP53-05841,clinical,-3.81,-3.2,0.203,0.0,0.203,0.28,0.14,0.731,0.62,0.249,0.231,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,5
p.P278S,WM-TP53-07201,WM-TP53-07201,screening,-4.52,-3.73,0.263,0.065,0.263,0.325,0.183,0.758,0.18,0.234,0.229,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000483,6
p.P278S,WM-TP53-00146,WM-TP53-00146,screening,-4.23,-3.39,0.28,0.029,0.28,0.308,0.173,0.769,0.18,0.273,0.219,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000789,7
p.P278S,WM-TP53-01438,WM-TP53-01438,screening,-4.27,-3.6,0.223,0.034,0.223,0.302,0.159,0.779,0.18,0.212,0.213,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,8
p.P278S,WM-TP53-05637,WM-TP53-05637,screening,-4.0,-3.22,0.26,0.0,0.26,0.289,0.156,0.716,0.18,0.26,0.198,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001163,9
p.P278S,WM-TP53-05280,WM-TP53-05280,screening,-4.3,-3.76,0.18,0.037,0.18,0.298,0.149,0.699,0.18,0.188,0.196,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000701,10
p.P278S,WM-TP53-03410,WM-TP53-03410,screening,-3.81,-3.2,0.203,0.0,0.203,0.28,0.14,0.79,0.18,0.229,0.195,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,11
p.P278S,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.163,0.599,0.88,0.388,0.192,0.876,"C278,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,12
p.P278S,WM-TP53-02764,WM-TP53-02764,screening,-3.74,-3.2,0.18,0.0,0.18,0.277,0.133,0.781,0.18,0.191,0.192,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,13
p.P278S,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.807,0.62,0.228,0.192,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.P278S,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.781,0.62,0.256,0.187,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,15
p.P278S,WM-TP53-01421,WM-TP53-01421,screening,-4.07,-3.2,0.29,0.009,0.29,0.298,0.168,0.561,0.18,0.321,0.185,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001033,16
p.P278S,WM-TP53-01795,WM-TP53-01795,screening,-3.94,-3.25,0.23,0.0,0.23,0.284,0.147,0.61,0.18,0.217,0.181,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001287,17
p.P278S,WM-TP53-05586,WM-TP53-05586,screening,-3.9,-3.42,0.16,0.0,0.16,0.274,0.128,0.688,0.18,0.172,0.177,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001377,18
p.P278S,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.709,0.62,0.267,0.177,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.P278S,WM-TP53-04600,WM-TP53-04600,screening,-3.53,-3.2,0.11,0.0,0.11,0.267,0.114,0.791,0.18,0.204,0.175,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002573,20
p.P278S,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.707,0.62,0.288,0.175,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.P278S,WM-TP53-00707,WM-TP53-00707,screening,-3.55,-3.2,0.117,0.0,0.117,0.268,0.116,0.792,0.18,0.24,0.174,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002487,22
p.P278S,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.708,0.62,0.333,0.172,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,23
p.P278S,WM-TP53-06810,WM-TP53-06810,clinical,-3.66,-3.2,0.153,0.0,0.153,0.273,0.126,0.508,0.62,0.543,0.168,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,24
p.P278S,WM-TP53-06623,WM-TP53-06623,screening,-3.56,-3.2,0.12,0.0,0.12,0.268,0.117,0.727,0.18,0.242,0.167,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002445,25
p.P278S,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.77,0.4,0.225,0.166,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,26
p.P278S,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.163,0.609,0.8,0.653,0.164,0.86,"C278,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.P278S,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.61,0.62,0.315,0.162,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.P278S,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.754,0.4,0.267,0.161,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.P278S,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.696,0.4,0.189,0.16,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.P278S,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.695,0.4,0.206,0.159,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,31
p.P278S,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.694,0.4,0.203,0.159,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.P278S,WM-TP53-00367,WM-TP53-00367,screening,-3.57,-3.2,0.123,0.0,0.123,0.268,0.117,0.638,0.18,0.228,0.158,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002405,33
p.P278S,WM-TP53-03546,WM-TP53-03546,screening,-3.44,-3.2,0.08,0.0,0.08,0.262,0.105,0.757,0.18,0.272,0.158,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002995,34
p.P278S,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.736,0.4,0.272,0.158,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.P278S,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.728,0.4,0.262,0.158,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,36
p.P278S,WM-TP53-01217,WM-TP53-01217,screening,-4.41,-3.83,0.193,0.051,0.193,0.307,0.158,0.509,0.18,0.491,0.157,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000582,37
p.P278S,WM-TP53-05246,WM-TP53-05246,preclinical,-3.71,-3.22,0.163,0.0,0.163,0.274,0.129,0.507,0.4,0.436,0.157,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,38
p.P278S,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.839,0.18,0.178,0.156,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,39
p.P278S,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.627,0.62,0.426,0.155,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.P278S,WM-TP53-04056,WM-TP53-04056,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.089,0.798,0.18,0.198,0.154,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,244.9,1.84,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,41
p.P278S,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.821,0.18,0.182,0.154,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.P278S,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.565,0.62,0.339,0.154,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.P278S,WM-TP53-02526,WM-TP53-02526,screening,-4.36,-3.8,0.187,0.045,0.187,0.303,0.154,0.505,0.18,0.495,0.153,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000633,44
p.P278S,WM-TP53-06079,WM-TP53-06079,screening,-3.33,-3.2,0.043,0.0,0.043,0.256,0.095,0.778,0.18,0.257,0.153,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,259.7,2.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003607,45
p.P278S,WM-TP53-02798,WM-TP53-02798,screening,-3.31,-3.2,0.037,0.0,0.037,0.256,0.093,0.767,0.18,0.225,0.153,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00373,46
p.P278S,WM-TP53-04991,WM-TP53-04991,screening,-3.41,-3.2,0.07,0.0,0.07,0.261,0.103,0.68,0.18,0.202,0.152,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003151,47
p.P278S,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.797,0.18,0.171,0.152,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.P278S,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.785,0.18,0.159,0.151,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,49
p.P278S,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.693,0.4,0.292,0.151,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.P278S,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.804,0.18,0.197,0.15,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.P278S,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.579,0.62,0.419,0.15,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.P278S,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.698,0.4,0.315,0.15,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,53
p.P278S,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.812,0.18,0.209,0.15,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.P278S,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.797,0.18,0.189,0.15,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.P278S,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.785,0.18,0.179,0.149,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.P278S,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.651,0.4,0.256,0.149,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.P278S,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.756,0.18,0.168,0.147,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,58
p.P278S,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.754,0.18,0.159,0.147,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.P278S,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.677,0.4,0.34,0.146,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.P278S,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.767,0.18,0.19,0.146,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.P278S,WM-TP53-05705,WM-TP53-05705,screening,-3.79,-3.31,0.16,0.0,0.16,0.274,0.128,0.601,0.18,0.452,0.145,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001658,62
p.P278S,WM-TP53-08000,WM-TP53-08000,screening,-3.33,-3.2,0.043,0.0,0.043,0.256,0.095,0.688,0.18,0.224,0.145,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003607,63
p.P278S,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.591,0.4,0.221,0.145,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.P278S,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.774,0.18,0.219,0.145,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.P278S,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.76,0.18,0.194,0.145,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.P278S,WM-TP53-06402,WM-TP53-06402,screening,-3.74,-3.32,0.14,0.0,0.14,0.271,0.122,0.615,0.18,0.418,0.144,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,67
p.P278S,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.528,0.62,0.412,0.144,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.P278S,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.776,0.18,0.234,0.144,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.P278S,WM-TP53-05331,WM-TP53-05331,screening,-3.31,-3.2,0.037,0.0,0.037,0.256,0.093,0.688,0.18,0.222,0.143,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,246.1,2.31,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00373,70
p.P278S,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.546,0.62,0.455,0.143,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.P278S,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.741,0.18,0.188,0.143,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.P278S,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.721,0.18,0.178,0.142,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.P278S,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.743,0.18,0.215,0.142,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,74
p.P278S,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.75,0.18,0.221,0.142,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.P278S,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.619,0.4,0.304,0.142,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.P278S,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.706,0.18,0.17,0.141,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.P278S,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.775,0.18,0.264,0.141,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.P278S,WM-TP53-07048,WM-TP53-07048,screening,-3.62,-3.2,0.14,0.0,0.14,0.271,0.122,0.592,0.18,0.433,0.14,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00221,79
p.P278S,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.73,0.18,0.221,0.14,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.P278S,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.734,0.18,0.227,0.14,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.P278S,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.633,0.4,0.339,0.14,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.P278S,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.754,0.18,0.248,0.14,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.P278S,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.744,0.18,0.235,0.14,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.P278S,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.744,0.18,0.232,0.14,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.P278S,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.735,0.18,0.231,0.139,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.P278S,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.733,0.18,0.231,0.139,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.P278S,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.746,0.18,0.249,0.139,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.P278S,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.731,0.18,0.244,0.138,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,89
p.P278S,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.764,0.18,0.286,0.138,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.P278S,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.741,0.18,0.256,0.138,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.P278S,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.734,0.18,0.244,0.138,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.P278S,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.718,0.18,0.224,0.138,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.P278S,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.742,0.18,0.267,0.137,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.P278S,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.494,0.62,0.45,0.137,0.824,"C278,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.P278S,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.756,0.18,0.292,0.137,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.P278S,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.737,0.18,0.258,0.137,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.P278S,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.716,0.18,0.249,0.136,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.P278S,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.686,0.18,0.196,0.136,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.P278S,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.694,0.18,0.212,0.136,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.P278S,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.736,0.18,0.272,0.136,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,101
p.P278S,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.724,0.18,0.275,0.135,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.P278S,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.69,0.18,0.223,0.135,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.P278S,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.727,0.18,0.268,0.135,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.P278S,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.712,0.18,0.272,0.133,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.P278S,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.721,0.18,0.288,0.133,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.P278S,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.598,0.4,0.377,0.133,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.P278S,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.724,0.18,0.288,0.133,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.P278S,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.709,0.18,0.289,0.132,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.P278S,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.728,0.18,0.318,0.132,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.P278S,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.705,0.18,0.293,0.131,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.P278S,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.71,0.18,0.299,0.131,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.P278S,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.706,0.18,0.31,0.13,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.P278S,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.671,0.18,0.253,0.13,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.P278S,WM-TP53-05365,WM-TP53-05365,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.089,0.694,0.18,0.366,0.129,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,269.4,3.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,115
p.P278S,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.679,0.18,0.279,0.129,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.P278S,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.704,0.18,0.32,0.128,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.P278S,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.687,0.18,0.295,0.128,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.P278S,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.679,0.18,0.301,0.127,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.P278S,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.686,0.18,0.307,0.127,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.P278S,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.675,0.18,0.301,0.127,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.P278S,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.7,0.18,0.329,0.127,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.P278S,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.631,0.18,0.235,0.127,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.P278S,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.686,0.18,0.309,0.127,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.P278S,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.579,0.4,0.424,0.127,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.P278S,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.673,0.18,0.309,0.126,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.P278S,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.683,0.18,0.317,0.126,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.P278S,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.624,0.18,0.236,0.126,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.P278S,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.672,0.18,0.303,0.126,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.P278S,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.666,0.18,0.309,0.125,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.P278S,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.676,0.18,0.322,0.125,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.P278S,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.658,0.18,0.298,0.125,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.P278S,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.515,0.4,0.356,0.125,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.P278S,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.681,0.18,0.334,0.125,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.P278S,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.609,0.18,0.228,0.124,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.P278S,WM-TP53-05739,WM-TP53-05739,screening,-3.43,-3.2,0.077,0.0,0.077,0.262,0.105,0.575,0.18,0.434,0.123,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,136
p.P278S,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.537,0.4,0.408,0.123,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.P278S,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.599,0.18,0.233,0.123,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.P278S,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.665,0.18,0.329,0.123,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.P278S,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.662,0.18,0.343,0.122,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.P278S,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.668,0.18,0.35,0.122,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.P278S,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.64,0.18,0.3,0.122,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.P278S,WM-TP53-03988,WM-TP53-03988,screening,-3.47,-3.2,0.09,0.0,0.09,0.264,0.108,0.555,0.18,0.463,0.121,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002847,143
p.P278S,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.657,0.18,0.343,0.121,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.P278S,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.65,0.18,0.349,0.12,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.P278S,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.662,0.18,0.364,0.12,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.P278S,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.641,0.18,0.373,0.117,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.P278S,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.601,0.18,0.324,0.116,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.P278S,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.624,0.18,0.356,0.116,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.P278S,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.632,0.18,0.366,0.116,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.P278S,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.642,0.18,0.38,0.116,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.P278S,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.578,0.18,0.291,0.116,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.P278S,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.581,0.18,0.307,0.115,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.P278S,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.592,0.18,0.317,0.115,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.P278S,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.629,0.18,0.373,0.115,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.P278S,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.536,0.4,0.506,0.115,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,156
p.P278S,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.631,0.18,0.376,0.115,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.P278S,WM-TP53-05093,WM-TP53-05093,screening,-3.41,-3.2,0.07,0.0,0.07,0.261,0.103,0.523,0.18,0.447,0.114,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003151,158
p.P278S,WM-TP53-02730,WM-TP53-02730,screening,-3.31,-3.2,0.037,0.0,0.037,0.256,0.093,0.572,0.18,0.414,0.114,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00373,159
p.P278S,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.617,0.18,0.374,0.114,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.P278S,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.506,0.4,0.489,0.113,0.78,"C278,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,161
p.P278S,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.634,0.18,0.418,0.112,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.P278S,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.603,0.18,0.403,0.11,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,163
p.P278S,WM-TP53-02492,WM-TP53-02492,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.092,0.546,0.18,0.419,0.109,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,164
p.P278S,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.6,0.18,0.402,0.109,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.P278S,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.587,0.18,0.418,0.107,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.P278S,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.601,0.18,0.428,0.107,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.P278S,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.572,0.18,0.409,0.106,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.P278S,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.608,0.18,0.459,0.106,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.P278S,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.558,0.18,0.411,0.104,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.P278S,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.568,0.18,0.418,0.104,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.P278S,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.597,0.18,0.464,0.104,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.P278S,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.555,0.18,0.411,0.103,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.P278S,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.572,0.18,0.436,0.103,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.P278S,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.544,0.18,0.411,0.102,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.P278S,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.59,0.18,0.486,0.102,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.P278S,WM-TP53-00299,WM-TP53-00299,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.084,0.581,0.18,0.488,0.101,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,177
p.P278S,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.556,0.18,0.437,0.101,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.P278S,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.559,0.18,0.448,0.101,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.P278S,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.539,0.18,0.416,0.101,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.P278S,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.554,0.18,0.444,0.101,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.P278S,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.527,0.18,0.418,0.099,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.P278S,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.554,0.18,0.458,0.099,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.P278S,WM-TP53-01472,WM-TP53-01472,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.089,0.522,0.18,0.496,0.098,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,184
p.P278S,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.539,0.18,0.46,0.098,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.P278S,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.532,0.18,0.447,0.098,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.P278S,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.506,0.18,0.42,0.097,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.P278S,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.647,0.18,0.634,0.097,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.P278S,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.65,0.18,0.634,0.097,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.P278S,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.557,0.18,0.521,0.095,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.P278S,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.53,0.18,0.474,0.095,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.P278S,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.513,0.18,0.451,0.095,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.P278S,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.646,0.18,0.647,0.095,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.P278S,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.528,0.18,0.492,0.094,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.P278S,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.553,0.18,0.524,0.094,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.P278S,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.467,0.18,0.409,0.093,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.P278S,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.525,0.18,0.49,0.093,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.P278S,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.503,0.18,0.48,0.092,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.P278S,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.507,0.18,0.483,0.092,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.P278S,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.61,0.18,0.641,0.092,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.P278S,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.533,0.18,0.53,0.091,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.P278S,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.482,0.18,0.469,0.09,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.P278S,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.504,0.18,0.504,0.09,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.P278S,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.494,0.18,0.489,0.09,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.P278S,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.509,0.18,0.516,0.089,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.P278S,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.517,0.18,0.529,0.089,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.P278S,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.508,0.18,0.538,0.088,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.P278S,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.508,0.18,0.543,0.087,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.P278S,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.474,0.18,0.544,0.083,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.P278S,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.484,0.18,0.557,0.083,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.P278S,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.461,0.18,0.52,0.083,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.P278S,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.479,0.18,0.574,0.081,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.P278S,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.447,0.18,0.541,0.08,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.P278S,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.469,0.18,0.58,0.079,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.P278S,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.453,0.18,0.58,0.078,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.P278S,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.437,0.18,0.57,0.076,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.P278S,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.537,0.18,0.736,0.075,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.P278S,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.528,0.18,0.739,0.074,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.P278S,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.538,0.18,0.758,0.074,0.736,"C278,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.P278S,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.404,0.18,0.779,0.056,0.636,"C278,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.Q144L,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.75,"C144,R158,M160,Y163",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.Q144L,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.75,"C144,R158,M160,Y163",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.Q144L,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.67,"C144,R158,M160,Y163",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.Q144L,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.67,"C144,R158,M160,Y163",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.Q144L,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.714,"C144,R158,M160,Y163",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.Q144L,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.626,"C144,R158,M160,Y163",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.Q144L,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.626,"C144,R158,M160,Y163",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.Q144L,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.626,"C144,R158,M160,Y163",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.Q144L,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.626,"C144,R158,M160,Y163",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.Q144L,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.766,"C144,R158,M160,Y163",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.Q144L,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.626,"C144,R158,M160,Y163",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.Q144L,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.626,"C144,R158,M160,Y163",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.Q144L,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.714,"C144,R158,M160,Y163",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.Q144L,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.714,"C144,R158,M160,Y163",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.Q144L,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.626,"C144,R158,M160,Y163",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.Q144L,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.714,"C144,R158,M160,Y163",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.Q144L,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.626,"C144,R158,M160,Y163",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.Q144L,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.626,"C144,R158,M160,Y163",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.Q144L,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.714,"C144,R158,M160,Y163",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.Q144L,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.626,"C144,R158,M160,Y163",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.Q144L,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.714,"C144,R158,M160,Y163",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.Q144L,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.626,"C144,R158,M160,Y163",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.Q144L,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.714,"C144,R158,M160,Y163",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.Q144L,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.67,"C144,R158,M160,Y163",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.Q144L,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.75,"C144,R158,M160,Y163",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.Q144L,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.626,"C144,R158,M160,Y163",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.Q144L,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.714,"C144,R158,M160,Y163",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.Q144L,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.67,"C144,R158,M160,Y163",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.Q144L,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.67,"C144,R158,M160,Y163",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.Q144L,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.67,"C144,R158,M160,Y163",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.Q144L,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.626,"C144,R158,M160,Y163",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.Q144L,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.67,"C144,R158,M160,Y163",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.Q144L,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.67,"C144,R158,M160,Y163",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.Q144L,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.67,"C144,R158,M160,Y163",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.Q144L,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.626,"C144,R158,M160,Y163",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.Q144L,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.67,"C144,R158,M160,Y163",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.Q144L,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.714,"C144,R158,M160,Y163",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.Q144L,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.714,"C144,R158,M160,Y163",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.Q144L,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.626,"C144,R158,M160,Y163",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.Q144L,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.626,"C144,R158,M160,Y163",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.Q144L,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.626,"C144,R158,M160,Y163",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.Q144L,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.626,"C144,R158,M160,Y163",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.Q144L,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.67,"C144,R158,M160,Y163",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.Q144L,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.626,"C144,R158,M160,Y163",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.Q144L,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.626,"C144,R158,M160,Y163",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.Q144L,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.67,"C144,R158,M160,Y163",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.Q144L,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.626,"C144,R158,M160,Y163",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.Q144L,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.626,"C144,R158,M160,Y163",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.Q144L,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.626,"C144,R158,M160,Y163",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.Q144L,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.714,"C144,R158,M160,Y163",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.Q144L,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.626,"C144,R158,M160,Y163",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.Q144L,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.67,"C144,R158,M160,Y163",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.Q144L,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.626,"C144,R158,M160,Y163",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.Q144L,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.626,"C144,R158,M160,Y163",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.Q144L,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.626,"C144,R158,M160,Y163",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.Q144L,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.67,"C144,R158,M160,Y163",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.Q144L,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.626,"C144,R158,M160,Y163",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.Q144L,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.626,"C144,R158,M160,Y163",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.Q144L,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.67,"C144,R158,M160,Y163",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.Q144L,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.626,"C144,R158,M160,Y163",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.Q144L,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.626,"C144,R158,M160,Y163",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.Q144L,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.626,"C144,R158,M160,Y163",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.Q144L,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.714,"C144,R158,M160,Y163",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.Q144L,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.626,"C144,R158,M160,Y163",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.Q144L,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.714,"C144,R158,M160,Y163",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.Q144L,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.626,"C144,R158,M160,Y163",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.Q144L,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.626,"C144,R158,M160,Y163",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.Q144L,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.626,"C144,R158,M160,Y163",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.Q144L,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.626,"C144,R158,M160,Y163",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.Q144L,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.626,"C144,R158,M160,Y163",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.Q144L,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.626,"C144,R158,M160,Y163",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.Q144L,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.626,"C144,R158,M160,Y163",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.Q144L,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.67,"C144,R158,M160,Y163",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.Q144L,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.626,"C144,R158,M160,Y163",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.Q144L,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.67,"C144,R158,M160,Y163",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.Q144L,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.626,"C144,R158,M160,Y163",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.Q144L,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.626,"C144,R158,M160,Y163",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.Q144L,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.626,"C144,R158,M160,Y163",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.Q144L,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.626,"C144,R158,M160,Y163",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.Q144L,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.626,"C144,R158,M160,Y163",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.Q144L,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.626,"C144,R158,M160,Y163",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.Q144L,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.626,"C144,R158,M160,Y163",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.Q144L,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.626,"C144,R158,M160,Y163",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.Q144L,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.626,"C144,R158,M160,Y163",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.Q144L,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.626,"C144,R158,M160,Y163",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.Q144L,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.626,"C144,R158,M160,Y163",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.Q144L,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.626,"C144,R158,M160,Y163",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.Q144L,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.626,"C144,R158,M160,Y163",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.Q144L,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.626,"C144,R158,M160,Y163",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.Q144L,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.626,"C144,R158,M160,Y163",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.Q144L,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.714,"C144,R158,M160,Y163",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.Q144L,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.626,"C144,R158,M160,Y163",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.Q144L,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.626,"C144,R158,M160,Y163",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.Q144L,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.626,"C144,R158,M160,Y163",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.Q144L,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.626,"C144,R158,M160,Y163",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.Q144L,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.626,"C144,R158,M160,Y163",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.Q144L,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.626,"C144,R158,M160,Y163",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.Q144L,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.626,"C144,R158,M160,Y163",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.Q144L,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.626,"C144,R158,M160,Y163",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.Q144L,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.626,"C144,R158,M160,Y163",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.Q144L,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.626,"C144,R158,M160,Y163",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.Q144L,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.626,"C144,R158,M160,Y163",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.Q144L,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.626,"C144,R158,M160,Y163",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.Q144L,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.67,"C144,R158,M160,Y163",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.Q144L,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.626,"C144,R158,M160,Y163",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.Q144L,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.626,"C144,R158,M160,Y163",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.Q144L,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.626,"C144,R158,M160,Y163",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.Q144L,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.626,"C144,R158,M160,Y163",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.Q144L,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.626,"C144,R158,M160,Y163",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.Q144L,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.626,"C144,R158,M160,Y163",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.Q144L,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.626,"C144,R158,M160,Y163",Pass,False,True,429.0,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.Q144L,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.626,"C144,R158,M160,Y163",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.Q144L,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.626,"C144,R158,M160,Y163",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.Q144L,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.626,"C144,R158,M160,Y163",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.Q144L,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.626,"C144,R158,M160,Y163",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.Q144L,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.626,"C144,R158,M160,Y163",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.Q144L,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.626,"C144,R158,M160,Y163",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.Q144L,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.626,"C144,R158,M160,Y163",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.Q144L,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.626,"C144,R158,M160,Y163",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.Q144L,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.67,"C144,R158,M160,Y163",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.Q144L,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.626,"C144,R158,M160,Y163",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.Q144L,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.626,"C144,R158,M160,Y163",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.Q144L,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.626,"C144,R158,M160,Y163",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.Q144L,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.626,"C144,R158,M160,Y163",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.Q144L,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.626,"C144,R158,M160,Y163",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.Q144L,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.626,"C144,R158,M160,Y163",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.Q144L,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.626,"C144,R158,M160,Y163",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.Q144L,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.626,"C144,R158,M160,Y163",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.Q144L,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.626,"C144,R158,M160,Y163",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.Q144L,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.67,"C144,R158,M160,Y163",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.Q144L,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.626,"C144,R158,M160,Y163",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.Q144L,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.626,"C144,R158,M160,Y163",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.Q144L,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.67,"C144,R158,M160,Y163",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.Q144L,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.626,"C144,R158,M160,Y163",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.Q144L,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.626,"C144,R158,M160,Y163",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.Q144L,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.626,"C144,R158,M160,Y163",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.Q144L,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.626,"C144,R158,M160,Y163",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.Q144L,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.626,"C144,R158,M160,Y163",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.Q144L,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.626,"C144,R158,M160,Y163",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.Q144L,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.626,"C144,R158,M160,Y163",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.Q144L,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.626,"C144,R158,M160,Y163",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.Q144L,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.626,"C144,R158,M160,Y163",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.Q144L,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.626,"C144,R158,M160,Y163",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.Q144L,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.626,"C144,R158,M160,Y163",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.Q144L,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.626,"C144,R158,M160,Y163",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.Q144L,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.626,"C144,R158,M160,Y163",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.Q144L,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.626,"C144,R158,M160,Y163",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.Q144L,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.626,"C144,R158,M160,Y163",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.Q144L,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.626,"C144,R158,M160,Y163",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.Q144L,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.626,"C144,R158,M160,Y163",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.Q144L,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.626,"C144,R158,M160,Y163",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.Q144L,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.67,"C144,R158,M160,Y163",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.Q144L,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.626,"C144,R158,M160,Y163",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.Q144L,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.626,"C144,R158,M160,Y163",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.Q144L,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.67,"C144,R158,M160,Y163",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.Q144L,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.626,"C144,R158,M160,Y163",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.Q144L,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.626,"C144,R158,M160,Y163",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.Q144L,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.626,"C144,R158,M160,Y163",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.Q144L,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.626,"C144,R158,M160,Y163",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.Q144L,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.626,"C144,R158,M160,Y163",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.Q144L,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.626,"C144,R158,M160,Y163",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.Q144L,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.626,"C144,R158,M160,Y163",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.Q144L,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.626,"C144,R158,M160,Y163",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.Q144L,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.626,"C144,R158,M160,Y163",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.Q144L,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.626,"C144,R158,M160,Y163",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.Q144L,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.626,"C144,R158,M160,Y163",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.Q144L,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.626,"C144,R158,M160,Y163",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.Q144L,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.626,"C144,R158,M160,Y163",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.Q144L,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.626,"C144,R158,M160,Y163",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.Q144L,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.626,"C144,R158,M160,Y163",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.Q144L,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.626,"C144,R158,M160,Y163",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.Q144L,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.626,"C144,R158,M160,Y163",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.Q144L,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.626,"C144,R158,M160,Y163",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.Q144L,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.626,"C144,R158,M160,Y163",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.Q144L,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.626,"C144,R158,M160,Y163",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.Q144L,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.626,"C144,R158,M160,Y163",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.Q144L,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.626,"C144,R158,M160,Y163",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.Q144L,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.626,"C144,R158,M160,Y163",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.Q144L,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.626,"C144,R158,M160,Y163",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.Q144L,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.626,"C144,R158,M160,Y163",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.Q144L,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.626,"C144,R158,M160,Y163",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.Q144L,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.626,"C144,R158,M160,Y163",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.Q144L,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.626,"C144,R158,M160,Y163",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.Q144L,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.626,"C144,R158,M160,Y163",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.Q144L,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.626,"C144,R158,M160,Y163",Pass,False,False,552.3,4.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.Q144L,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.626,"C144,R158,M160,Y163",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.Q144L,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.626,"C144,R158,M160,Y163",Pass,False,True,404.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.Q144L,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.626,"C144,R158,M160,Y163",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.Q144L,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.626,"C144,R158,M160,Y163",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.Q144L,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.626,"C144,R158,M160,Y163",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.Q144L,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.626,"C144,R158,M160,Y163",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.Q144L,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.626,"C144,R158,M160,Y163",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.Q144L,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.626,"C144,R158,M160,Y163",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.Q144L,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.626,"C144,R158,M160,Y163",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.Q144L,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.626,"C144,R158,M160,Y163",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.Q144L,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.626,"C144,R158,M160,Y163",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.Q144L,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.626,"C144,R158,M160,Y163",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.Q144L,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.626,"C144,R158,M160,Y163",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.Q144L,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.626,"C144,R158,M160,Y163",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.Q144L,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.626,"C144,R158,M160,Y163",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.Q144L,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.626,"C144,R158,M160,Y163",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.Q144L,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.626,"C144,R158,M160,Y163",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.Q144L,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.626,"C144,R158,M160,Y163",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.Q144L,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.626,"C144,R158,M160,Y163",Pass,False,True,404.0,2.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.Q144L,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.626,"C144,R158,M160,Y163",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.Q144L,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.626,"C144,R158,M160,Y163",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.Q144L,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.626,"C144,R158,M160,Y163",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.Q144L,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.626,"C144,R158,M160,Y163",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.Q144L,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.626,"C144,R158,M160,Y163",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.Q144L,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.626,"C144,R158,M160,Y163",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.Q144L,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.626,"C144,R158,M160,Y163",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.Q144L,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.626,"C144,R158,M160,Y163",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.Q144L,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.626,"C144,R158,M160,Y163",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.Q144L,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.626,"C144,R158,M160,Y163",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.Q144L,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.626,"C144,R158,M160,Y163",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.Q144L,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.626,"C144,R158,M160,Y163",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.Q144L,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.626,"C144,R158,M160,Y163",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.Q144L,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.626,"C144,R158,M160,Y163",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.Q144L,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.626,"C144,R158,M160,Y163",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.Q144L,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.526,"C144,R158,M160,Y163",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.R110C,CTRL-001,PK083,preclinical,-4.56,-3.31,0.417,0.07,0.417,0.351,0.322,0.645,0.8,0.363,0.32,0.86,"C110,R158,M160,Y163",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000452,1
p.R110C,WM-TP53-00860,WM-TP53-00860,preclinical,-4.32,-3.26,0.353,0.04,0.353,0.325,0.212,0.719,0.4,0.292,0.257,0.78,"C110,R158,M160,Y163",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,2
p.R110C,CTRL-003,PK11000,preclinical,-3.4,-3.2,0.067,0.0,0.067,0.26,0.196,0.854,0.8,0.171,0.25,0.86,"C110,R158,M160,Y163",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003204,3
p.R110C,WM-TP53-07201,WM-TP53-07201,screening,-4.63,-3.73,0.3,0.079,0.3,0.338,0.213,0.758,0.18,0.234,0.246,0.736,"C110,R158,M160,Y163",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000401,4
p.R110C,WM-TP53-05841,WM-TP53-05841,clinical,-3.97,-3.2,0.257,0.0,0.257,0.289,0.169,0.731,0.62,0.249,0.246,0.824,"C110,R158,M160,Y163",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001223,5
p.R110C,WM-TP53-02322,WM-TP53-02322,preclinical,-4.37,-3.78,0.197,0.046,0.197,0.305,0.171,0.812,0.4,0.176,0.242,0.78,"C110,R158,M160,Y163",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000623,6
p.R110C,WM-TP53-00146,WM-TP53-00146,screening,-4.31,-3.39,0.307,0.039,0.307,0.317,0.199,0.769,0.18,0.273,0.231,0.736,"C110,R158,M160,Y163",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000689,7
p.R110C,WM-TP53-01438,WM-TP53-01438,screening,-4.34,-3.6,0.247,0.042,0.247,0.31,0.183,0.779,0.18,0.212,0.223,0.736,"C110,R158,M160,Y163",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000655,8
p.R110C,WM-TP53-05637,WM-TP53-05637,screening,-4.06,-3.22,0.28,0.007,0.28,0.296,0.178,0.716,0.18,0.26,0.207,0.736,"C110,R158,M160,Y163",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001051,9
p.R110C,WM-TP53-01421,WM-TP53-01421,screening,-4.21,-3.2,0.337,0.026,0.337,0.315,0.202,0.561,0.18,0.321,0.205,0.736,"C110,R158,M160,Y163",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000816,10
p.R110C,WM-TP53-05280,WM-TP53-05280,screening,-4.34,-3.76,0.193,0.042,0.193,0.302,0.168,0.699,0.18,0.188,0.203,0.736,"C110,R158,M160,Y163",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000655,11
p.R110C,WM-TP53-02764,WM-TP53-02764,screening,-3.85,-3.2,0.217,0.0,0.217,0.283,0.158,0.781,0.18,0.191,0.203,0.736,"C110,R158,M160,Y163",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,12
p.R110C,WM-TP53-03410,WM-TP53-03410,screening,-3.86,-3.2,0.22,0.0,0.22,0.283,0.159,0.79,0.18,0.229,0.202,0.736,"C110,R158,M160,Y163",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001473,13
p.R110C,WM-TP53-01795,WM-TP53-01795,screening,-4.08,-3.25,0.277,0.01,0.277,0.297,0.179,0.61,0.18,0.217,0.198,0.736,"C110,R158,M160,Y163",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001016,14
p.R110C,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.599,0.88,0.388,0.194,0.876,"C110,R158,M160,Y163",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,15
p.R110C,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.807,0.62,0.228,0.194,0.824,"C110,R158,M160,Y163",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.R110C,WM-TP53-00707,WM-TP53-00707,screening,-3.75,-3.2,0.183,0.0,0.183,0.277,0.148,0.792,0.18,0.24,0.192,0.736,"C110,R158,M160,Y163",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001774,17
p.R110C,WM-TP53-07949,WM-TP53-07949,approved,-3.27,-3.2,0.023,0.0,0.023,0.253,0.103,0.651,0.72,0.244,0.19,0.844,"C110,R158,M160,Y163",Pass,False,True,255.6,2.69,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003991,18
p.R110C,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.781,0.62,0.256,0.189,0.824,"C110,R158,M160,Y163",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.R110C,WM-TP53-04600,WM-TP53-04600,screening,-3.63,-3.2,0.143,0.0,0.143,0.271,0.137,0.791,0.18,0.204,0.185,0.736,"C110,R158,M160,Y163",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,20
p.R110C,WM-TP53-05586,WM-TP53-05586,screening,-3.95,-3.42,0.177,0.0,0.177,0.277,0.147,0.688,0.18,0.172,0.184,0.736,"C110,R158,M160,Y163",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,21
p.R110C,WM-TP53-06623,WM-TP53-06623,screening,-3.72,-3.2,0.173,0.0,0.173,0.276,0.145,0.727,0.18,0.242,0.181,0.736,"C110,R158,M160,Y163",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001866,22
p.R110C,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.709,0.62,0.267,0.179,0.824,"C110,R158,M160,Y163",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,23
p.R110C,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.707,0.62,0.288,0.177,0.824,"C110,R158,M160,Y163",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.R110C,WM-TP53-06810,WM-TP53-06810,clinical,-3.71,-3.2,0.17,0.0,0.17,0.276,0.145,0.508,0.62,0.543,0.175,0.824,"C110,R158,M160,Y163",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,25
p.R110C,WM-TP53-00367,WM-TP53-00367,screening,-3.74,-3.2,0.18,0.0,0.18,0.277,0.147,0.638,0.18,0.228,0.174,0.736,"C110,R158,M160,Y163",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,26
p.R110C,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.708,0.62,0.333,0.174,0.824,"C110,R158,M160,Y163",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.R110C,WM-TP53-03546,WM-TP53-03546,screening,-3.59,-3.2,0.13,0.0,0.13,0.27,0.133,0.757,0.18,0.272,0.172,0.736,"C110,R158,M160,Y163",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002325,28
p.R110C,WM-TP53-06079,WM-TP53-06079,screening,-3.53,-3.2,0.11,0.0,0.11,0.267,0.128,0.778,0.18,0.257,0.171,0.736,"C110,R158,M160,Y163",Pass,False,True,259.7,2.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002573,29
p.R110C,WM-TP53-04056,WM-TP53-04056,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.117,0.798,0.18,0.198,0.169,0.736,"C110,R158,M160,Y163",Pass,False,True,244.9,1.84,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,30
p.R110C,WM-TP53-02798,WM-TP53-02798,screening,-3.47,-3.2,0.09,0.0,0.09,0.264,0.122,0.767,0.18,0.225,0.168,0.736,"C110,R158,M160,Y163",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002847,31
p.R110C,WM-TP53-04481,WM-TP53-04481,preclinical,-3.38,-3.2,0.06,0.0,0.06,0.259,0.114,0.711,0.4,0.321,0.168,0.78,"C110,R158,M160,Y163",Pass,False,True,275.4,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003314,32
p.R110C,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.177,0.609,0.8,0.653,0.166,0.86,"C110,R158,M160,Y163",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.R110C,WM-TP53-01217,WM-TP53-01217,screening,-4.46,-3.83,0.21,0.057,0.21,0.313,0.179,0.509,0.18,0.491,0.165,0.736,"C110,R158,M160,Y163",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000535,34
p.R110C,WM-TP53-04991,WM-TP53-04991,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.129,0.68,0.18,0.202,0.165,0.736,"C110,R158,M160,Y163",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,35
p.R110C,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.61,0.62,0.315,0.164,0.824,"C110,R158,M160,Y163",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,36
p.R110C,WM-TP53-05246,WM-TP53-05246,preclinical,-3.76,-3.22,0.18,0.0,0.18,0.277,0.147,0.507,0.4,0.436,0.163,0.78,"C110,R158,M160,Y163",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001744,37
p.R110C,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.754,0.4,0.267,0.163,0.78,"C110,R158,M160,Y163",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.R110C,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.696,0.4,0.189,0.162,0.78,"C110,R158,M160,Y163",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,39
p.R110C,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.695,0.4,0.206,0.161,0.78,"C110,R158,M160,Y163",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.R110C,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.694,0.4,0.203,0.161,0.78,"C110,R158,M160,Y163",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.R110C,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.736,0.4,0.272,0.16,0.78,"C110,R158,M160,Y163",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.R110C,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.728,0.4,0.262,0.16,0.78,"C110,R158,M160,Y163",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.R110C,WM-TP53-02526,WM-TP53-02526,screening,-4.4,-3.8,0.2,0.05,0.2,0.307,0.173,0.505,0.18,0.495,0.159,0.736,"C110,R158,M160,Y163",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000592,44
p.R110C,WM-TP53-05331,WM-TP53-05331,screening,-3.48,-3.2,0.093,0.0,0.093,0.264,0.123,0.688,0.18,0.222,0.159,0.736,"C110,R158,M160,Y163",Pass,False,True,246.1,2.31,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002799,45
p.R110C,WM-TP53-08000,WM-TP53-08000,screening,-3.47,-3.2,0.09,0.0,0.09,0.264,0.122,0.688,0.18,0.224,0.158,0.736,"C110,R158,M160,Y163",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002847,46
p.R110C,WM-TP53-03172,WM-TP53-03172,screening,-3.27,-3.2,0.023,0.0,0.023,0.253,0.103,0.797,0.18,0.189,0.158,0.736,"C110,R158,M160,Y163",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003991,47
p.R110C,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.839,0.18,0.178,0.158,0.736,"C110,R158,M160,Y163",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.R110C,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.627,0.62,0.426,0.157,0.824,"C110,R158,M160,Y163",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,49
p.R110C,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.821,0.18,0.182,0.156,0.736,"C110,R158,M160,Y163",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.R110C,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.565,0.62,0.339,0.156,0.824,"C110,R158,M160,Y163",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.R110C,WM-TP53-05705,WM-TP53-05705,screening,-3.88,-3.31,0.19,0.0,0.19,0.278,0.15,0.601,0.18,0.452,0.154,0.736,"C110,R158,M160,Y163",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001424,52
p.R110C,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.797,0.18,0.171,0.154,0.736,"C110,R158,M160,Y163",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,53
p.R110C,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.785,0.18,0.159,0.153,0.736,"C110,R158,M160,Y163",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.R110C,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.693,0.4,0.292,0.153,0.78,"C110,R158,M160,Y163",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.R110C,WM-TP53-07048,WM-TP53-07048,screening,-3.75,-3.2,0.183,0.0,0.183,0.277,0.148,0.592,0.18,0.433,0.152,0.736,"C110,R158,M160,Y163",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001774,56
p.R110C,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.804,0.18,0.197,0.152,0.736,"C110,R158,M160,Y163",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.R110C,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.579,0.62,0.419,0.152,0.824,"C110,R158,M160,Y163",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,58
p.R110C,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.698,0.4,0.315,0.152,0.78,"C110,R158,M160,Y163",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.R110C,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.812,0.18,0.209,0.152,0.736,"C110,R158,M160,Y163",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.R110C,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.785,0.18,0.179,0.151,0.736,"C110,R158,M160,Y163",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.R110C,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.651,0.4,0.256,0.151,0.78,"C110,R158,M160,Y163",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,62
p.R110C,WM-TP53-06402,WM-TP53-06402,screening,-3.79,-3.32,0.157,0.0,0.157,0.274,0.141,0.615,0.18,0.418,0.15,0.736,"C110,R158,M160,Y163",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001658,63
p.R110C,WM-TP53-06555,WM-TP53-06555,screening,-3.41,-3.2,0.07,0.0,0.07,0.261,0.117,0.719,0.18,0.329,0.149,0.736,"C110,R158,M160,Y163",Pass,False,True,265.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003151,64
p.R110C,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.756,0.18,0.168,0.149,0.736,"C110,R158,M160,Y163",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.R110C,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.754,0.18,0.159,0.149,0.736,"C110,R158,M160,Y163",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.R110C,WM-TP53-05365,WM-TP53-05365,screening,-3.48,-3.2,0.093,0.0,0.093,0.264,0.123,0.694,0.18,0.366,0.148,0.736,"C110,R158,M160,Y163",Pass,False,True,269.4,3.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002799,67
p.R110C,WM-TP53-01625,WM-TP53-01625,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.108,0.694,0.18,0.212,0.148,0.736,"C110,R158,M160,Y163",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,68
p.R110C,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.677,0.4,0.34,0.148,0.78,"C110,R158,M160,Y163",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.R110C,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.767,0.18,0.19,0.148,0.736,"C110,R158,M160,Y163",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.R110C,WM-TP53-06249,WM-TP53-06249,screening,-3.22,-3.2,0.007,0.0,0.007,0.251,0.099,0.76,0.18,0.217,0.147,0.736,"C110,R158,M160,Y163",Pass,False,True,273.1,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004343,71
p.R110C,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.591,0.4,0.221,0.147,0.78,"C110,R158,M160,Y163",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.R110C,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.774,0.18,0.219,0.147,0.736,"C110,R158,M160,Y163",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.R110C,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.528,0.62,0.412,0.146,0.824,"C110,R158,M160,Y163",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,74
p.R110C,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.776,0.18,0.234,0.146,0.736,"C110,R158,M160,Y163",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.R110C,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.546,0.62,0.455,0.145,0.824,"C110,R158,M160,Y163",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.R110C,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.741,0.18,0.188,0.145,0.736,"C110,R158,M160,Y163",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.R110C,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.721,0.18,0.178,0.144,0.736,"C110,R158,M160,Y163",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.R110C,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.743,0.18,0.215,0.144,0.736,"C110,R158,M160,Y163",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.R110C,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.75,0.18,0.221,0.144,0.736,"C110,R158,M160,Y163",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.R110C,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.619,0.4,0.304,0.144,0.78,"C110,R158,M160,Y163",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.R110C,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.706,0.18,0.17,0.143,0.736,"C110,R158,M160,Y163",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.R110C,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.775,0.18,0.264,0.143,0.736,"C110,R158,M160,Y163",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.R110C,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.633,0.4,0.339,0.142,0.78,"C110,R158,M160,Y163",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.R110C,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.754,0.18,0.248,0.142,0.736,"C110,R158,M160,Y163",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.R110C,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.744,0.18,0.235,0.142,0.736,"C110,R158,M160,Y163",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.R110C,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.744,0.18,0.232,0.142,0.736,"C110,R158,M160,Y163",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.R110C,WM-TP53-06487,WM-TP53-06487,screening,-3.49,-3.2,0.097,0.0,0.097,0.265,0.124,0.637,0.18,0.382,0.141,0.736,"C110,R158,M160,Y163",Pass,False,True,302.0,4.96,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002752,88
p.R110C,WM-TP53-05926,WM-TP53-05926,screening,-3.3,-3.2,0.033,0.0,0.033,0.255,0.106,0.66,0.18,0.224,0.141,0.736,"C110,R158,M160,Y163",Pass,False,True,246.6,2.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003794,89
p.R110C,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.73,0.18,0.221,0.141,0.736,"C110,R158,M160,Y163",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.R110C,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.734,0.18,0.227,0.141,0.736,"C110,R158,M160,Y163",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.R110C,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.735,0.18,0.231,0.141,0.736,"C110,R158,M160,Y163",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.R110C,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.733,0.18,0.231,0.141,0.736,"C110,R158,M160,Y163",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.R110C,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.746,0.18,0.249,0.141,0.736,"C110,R158,M160,Y163",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.R110C,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.731,0.18,0.244,0.14,0.736,"C110,R158,M160,Y163",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.R110C,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.764,0.18,0.286,0.14,0.736,"C110,R158,M160,Y163",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.R110C,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.741,0.18,0.256,0.14,0.736,"C110,R158,M160,Y163",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.R110C,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.734,0.18,0.244,0.14,0.736,"C110,R158,M160,Y163",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.R110C,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.742,0.18,0.267,0.139,0.736,"C110,R158,M160,Y163",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.R110C,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.494,0.62,0.45,0.139,0.824,"C110,R158,M160,Y163",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.R110C,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.756,0.18,0.292,0.139,0.736,"C110,R158,M160,Y163",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,101
p.R110C,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.737,0.18,0.258,0.139,0.736,"C110,R158,M160,Y163",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.R110C,WM-TP53-03988,WM-TP53-03988,screening,-3.65,-3.2,0.15,0.0,0.15,0.273,0.139,0.555,0.18,0.463,0.138,0.736,"C110,R158,M160,Y163",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002101,103
p.R110C,WM-TP53-06997,WM-TP53-06997,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.098,0.703,0.18,0.237,0.138,0.736,"C110,R158,M160,Y163",Pass,False,True,258.1,2.58,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,104
p.R110C,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.716,0.18,0.249,0.138,0.736,"C110,R158,M160,Y163",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.R110C,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.686,0.18,0.196,0.138,0.736,"C110,R158,M160,Y163",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.R110C,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.736,0.18,0.272,0.138,0.736,"C110,R158,M160,Y163",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.R110C,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.69,0.18,0.223,0.137,0.736,"C110,R158,M160,Y163",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.R110C,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.727,0.18,0.268,0.137,0.736,"C110,R158,M160,Y163",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.R110C,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.724,0.18,0.275,0.136,0.736,"C110,R158,M160,Y163",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.R110C,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.712,0.18,0.272,0.135,0.736,"C110,R158,M160,Y163",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.R110C,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.721,0.18,0.288,0.135,0.736,"C110,R158,M160,Y163",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.R110C,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.598,0.4,0.377,0.135,0.78,"C110,R158,M160,Y163",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.R110C,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.724,0.18,0.288,0.135,0.736,"C110,R158,M160,Y163",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.R110C,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.709,0.18,0.289,0.134,0.736,"C110,R158,M160,Y163",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.R110C,WM-TP53-05739,WM-TP53-05739,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.129,0.575,0.18,0.434,0.133,0.736,"C110,R158,M160,Y163",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,116
p.R110C,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.705,0.18,0.293,0.133,0.736,"C110,R158,M160,Y163",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.R110C,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.71,0.18,0.299,0.133,0.736,"C110,R158,M160,Y163",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.R110C,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.671,0.18,0.253,0.132,0.736,"C110,R158,M160,Y163",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.R110C,WM-TP53-06028,WM-TP53-06028,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.111,0.644,0.18,0.374,0.131,0.736,"C110,R158,M160,Y163",Pass,False,True,292.0,4.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,120
p.R110C,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.706,0.18,0.31,0.131,0.736,"C110,R158,M160,Y163",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.R110C,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.679,0.18,0.279,0.131,0.736,"C110,R158,M160,Y163",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.R110C,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.704,0.18,0.32,0.13,0.736,"C110,R158,M160,Y163",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.R110C,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.679,0.18,0.301,0.129,0.736,"C110,R158,M160,Y163",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.R110C,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.686,0.18,0.307,0.129,0.736,"C110,R158,M160,Y163",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.R110C,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.675,0.18,0.301,0.129,0.736,"C110,R158,M160,Y163",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.R110C,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.7,0.18,0.329,0.129,0.736,"C110,R158,M160,Y163",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.R110C,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.686,0.18,0.309,0.129,0.736,"C110,R158,M160,Y163",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.R110C,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.579,0.4,0.424,0.129,0.78,"C110,R158,M160,Y163",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.R110C,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.673,0.18,0.309,0.128,0.736,"C110,R158,M160,Y163",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.R110C,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.683,0.18,0.317,0.128,0.736,"C110,R158,M160,Y163",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.R110C,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.624,0.18,0.236,0.128,0.736,"C110,R158,M160,Y163",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.R110C,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.672,0.18,0.303,0.128,0.736,"C110,R158,M160,Y163",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.R110C,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.631,0.18,0.235,0.128,0.736,"C110,R158,M160,Y163",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.R110C,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.666,0.18,0.309,0.127,0.736,"C110,R158,M160,Y163",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.R110C,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.676,0.18,0.322,0.127,0.736,"C110,R158,M160,Y163",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.R110C,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.658,0.18,0.298,0.127,0.736,"C110,R158,M160,Y163",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.R110C,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.515,0.4,0.356,0.127,0.78,"C110,R158,M160,Y163",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.R110C,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.681,0.18,0.334,0.127,0.736,"C110,R158,M160,Y163",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.R110C,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.609,0.18,0.228,0.126,0.736,"C110,R158,M160,Y163",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.R110C,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.537,0.4,0.408,0.125,0.78,"C110,R158,M160,Y163",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.R110C,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.599,0.18,0.233,0.125,0.736,"C110,R158,M160,Y163",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.R110C,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.665,0.18,0.329,0.125,0.736,"C110,R158,M160,Y163",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,143
p.R110C,WM-TP53-05093,WM-TP53-05093,screening,-3.51,-3.2,0.103,0.0,0.103,0.265,0.126,0.523,0.18,0.447,0.124,0.736,"C110,R158,M160,Y163",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002661,144
p.R110C,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.662,0.18,0.343,0.124,0.736,"C110,R158,M160,Y163",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.R110C,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.668,0.18,0.35,0.124,0.736,"C110,R158,M160,Y163",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.R110C,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.657,0.18,0.343,0.123,0.736,"C110,R158,M160,Y163",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.R110C,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.65,0.18,0.349,0.122,0.736,"C110,R158,M160,Y163",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.R110C,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.662,0.18,0.364,0.122,0.736,"C110,R158,M160,Y163",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.R110C,WM-TP53-02730,WM-TP53-02730,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.112,0.572,0.18,0.414,0.12,0.736,"C110,R158,M160,Y163",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,150
p.R110C,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.641,0.18,0.373,0.119,0.736,"C110,R158,M160,Y163",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.R110C,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.601,0.18,0.324,0.118,0.736,"C110,R158,M160,Y163",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.R110C,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.624,0.18,0.356,0.118,0.736,"C110,R158,M160,Y163",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.R110C,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.632,0.18,0.366,0.118,0.736,"C110,R158,M160,Y163",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.R110C,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.581,0.18,0.307,0.117,0.736,"C110,R158,M160,Y163",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.R110C,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.592,0.18,0.317,0.117,0.736,"C110,R158,M160,Y163",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,156
p.R110C,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.629,0.18,0.373,0.117,0.736,"C110,R158,M160,Y163",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.R110C,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.536,0.4,0.506,0.117,0.78,"C110,R158,M160,Y163",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,158
p.R110C,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.631,0.18,0.376,0.117,0.736,"C110,R158,M160,Y163",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.R110C,WM-TP53-02492,WM-TP53-02492,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.111,0.546,0.18,0.419,0.116,0.736,"C110,R158,M160,Y163",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,160
p.R110C,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.617,0.18,0.374,0.116,0.736,"C110,R158,M160,Y163",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,161
p.R110C,WM-TP53-00299,WM-TP53-00299,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.112,0.581,0.18,0.488,0.115,0.736,"C110,R158,M160,Y163",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,162
p.R110C,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.506,0.4,0.489,0.115,0.78,"C110,R158,M160,Y163",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,163
p.R110C,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.603,0.18,0.403,0.112,0.736,"C110,R158,M160,Y163",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.R110C,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.6,0.18,0.402,0.111,0.736,"C110,R158,M160,Y163",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.R110C,WM-TP53-01472,WM-TP53-01472,screening,-3.39,-3.2,0.063,0.0,0.063,0.259,0.114,0.522,0.18,0.496,0.11,0.736,"C110,R158,M160,Y163",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003259,166
p.R110C,WM-TP53-05671,WM-TP53-05671,screening,-3.3,-3.2,0.033,0.0,0.033,0.255,0.106,0.577,0.18,0.482,0.11,0.736,"C110,R158,M160,Y163",Pass,False,True,248.0,2.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003794,167
p.R110C,WM-TP53-03087,WM-TP53-03087,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.104,0.59,0.18,0.486,0.11,0.736,"C110,R158,M160,Y163",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,168
p.R110C,WM-TP53-06895,WM-TP53-06895,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.108,0.521,0.18,0.435,0.109,0.736,"C110,R158,M160,Y163",Pass,False,True,230.4,0.81,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,169
p.R110C,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.587,0.18,0.418,0.109,0.736,"C110,R158,M160,Y163",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.R110C,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.601,0.18,0.428,0.109,0.736,"C110,R158,M160,Y163",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.R110C,WM-TP53-06589,WM-TP53-06589,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.11,0.547,0.18,0.506,0.108,0.736,"C110,R158,M160,Y163",Pass,False,True,256.5,2.89,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,172
p.R110C,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.608,0.18,0.459,0.108,0.736,"C110,R158,M160,Y163",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.R110C,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.572,0.18,0.409,0.107,0.736,"C110,R158,M160,Y163",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.R110C,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.558,0.18,0.411,0.106,0.736,"C110,R158,M160,Y163",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.R110C,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.568,0.18,0.418,0.106,0.736,"C110,R158,M160,Y163",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.R110C,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.555,0.18,0.411,0.105,0.736,"C110,R158,M160,Y163",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.R110C,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.572,0.18,0.436,0.105,0.736,"C110,R158,M160,Y163",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.R110C,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.544,0.18,0.411,0.104,0.736,"C110,R158,M160,Y163",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.R110C,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.556,0.18,0.437,0.103,0.736,"C110,R158,M160,Y163",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.R110C,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.559,0.18,0.448,0.103,0.736,"C110,R158,M160,Y163",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.R110C,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.539,0.18,0.416,0.103,0.736,"C110,R158,M160,Y163",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.R110C,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.554,0.18,0.444,0.103,0.736,"C110,R158,M160,Y163",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.R110C,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.527,0.18,0.418,0.101,0.736,"C110,R158,M160,Y163",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.R110C,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.554,0.18,0.458,0.101,0.736,"C110,R158,M160,Y163",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.R110C,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.532,0.18,0.447,0.1,0.736,"C110,R158,M160,Y163",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.R110C,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.539,0.18,0.46,0.099,0.736,"C110,R158,M160,Y163",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.R110C,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.506,0.18,0.42,0.099,0.736,"C110,R158,M160,Y163",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.R110C,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.65,0.18,0.634,0.099,0.736,"C110,R158,M160,Y163",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.R110C,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.647,0.18,0.634,0.098,0.736,"C110,R158,M160,Y163",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.R110C,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.557,0.18,0.521,0.097,0.736,"C110,R158,M160,Y163",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.R110C,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.53,0.18,0.474,0.097,0.736,"C110,R158,M160,Y163",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.R110C,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.513,0.18,0.451,0.097,0.736,"C110,R158,M160,Y163",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.R110C,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.646,0.18,0.647,0.097,0.736,"C110,R158,M160,Y163",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.R110C,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.528,0.18,0.492,0.096,0.736,"C110,R158,M160,Y163",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.R110C,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.553,0.18,0.524,0.096,0.736,"C110,R158,M160,Y163",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.R110C,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.467,0.18,0.409,0.095,0.736,"C110,R158,M160,Y163",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.R110C,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.525,0.18,0.49,0.095,0.736,"C110,R158,M160,Y163",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.R110C,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.503,0.18,0.48,0.094,0.736,"C110,R158,M160,Y163",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.R110C,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.507,0.18,0.483,0.094,0.736,"C110,R158,M160,Y163",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.R110C,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.533,0.18,0.53,0.093,0.736,"C110,R158,M160,Y163",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.R110C,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.482,0.18,0.469,0.092,0.736,"C110,R158,M160,Y163",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.R110C,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.504,0.18,0.504,0.092,0.736,"C110,R158,M160,Y163",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.R110C,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.494,0.18,0.489,0.092,0.736,"C110,R158,M160,Y163",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.R110C,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.509,0.18,0.516,0.091,0.736,"C110,R158,M160,Y163",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.R110C,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.517,0.18,0.529,0.091,0.736,"C110,R158,M160,Y163",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.R110C,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.508,0.18,0.543,0.089,0.736,"C110,R158,M160,Y163",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.R110C,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.508,0.18,0.538,0.089,0.736,"C110,R158,M160,Y163",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.R110C,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.474,0.18,0.544,0.085,0.736,"C110,R158,M160,Y163",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.R110C,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.484,0.18,0.557,0.085,0.736,"C110,R158,M160,Y163",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.R110C,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.461,0.18,0.52,0.085,0.736,"C110,R158,M160,Y163",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.R110C,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.479,0.18,0.574,0.083,0.736,"C110,R158,M160,Y163",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.R110C,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.447,0.18,0.541,0.082,0.736,"C110,R158,M160,Y163",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.R110C,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.469,0.18,0.58,0.081,0.736,"C110,R158,M160,Y163",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.R110C,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.453,0.18,0.58,0.08,0.736,"C110,R158,M160,Y163",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.R110C,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.437,0.18,0.57,0.078,0.736,"C110,R158,M160,Y163",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.R110C,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.537,0.18,0.736,0.077,0.736,"C110,R158,M160,Y163",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.R110C,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.528,0.18,0.739,0.076,0.736,"C110,R158,M160,Y163",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.R110C,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.538,0.18,0.758,0.076,0.736,"C110,R158,M160,Y163",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.R110C,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.097,0.404,0.18,0.779,0.058,0.636,"C110,R158,M160,Y163",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.R175L,CTRL-001,PK083,preclinical,-5.11,-3.31,0.6,0.139,0.6,0.416,0.388,0.645,0.8,0.363,0.388,0.86,"C175,R158,M160,Y163",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"known-ligand-control,mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000178,1
p.R175L,WM-TP53-00860,WM-TP53-00860,preclinical,-4.72,-3.26,0.487,0.09,0.487,0.373,0.257,0.719,0.4,0.292,0.306,0.78,"C175,R158,M160,Y163",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000345,2
p.R175L,WM-TP53-07201,WM-TP53-07201,screening,-4.88,-3.73,0.383,0.11,0.383,0.368,0.236,0.758,0.18,0.234,0.275,0.736,"C175,R158,M160,Y163",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000263,3
p.R175L,WM-TP53-00146,WM-TP53-00146,screening,-4.66,-3.39,0.423,0.083,0.423,0.359,0.236,0.769,0.18,0.273,0.273,0.736,"C175,R158,M160,Y163",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000381,4
p.R175L,WM-TP53-05841,WM-TP53-05841,clinical,-4.16,-3.2,0.32,0.02,0.32,0.309,0.181,0.731,0.62,0.249,0.267,0.824,"C175,R158,M160,Y163",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000888,5
p.R175L,WM-TP53-01421,WM-TP53-01421,screening,-4.61,-3.2,0.47,0.076,0.47,0.362,0.246,0.561,0.18,0.321,0.253,0.736,"C175,R158,M160,Y163",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000415,6
p.R175L,WM-TP53-02322,WM-TP53-02322,preclinical,-4.45,-3.78,0.223,0.056,0.223,0.314,0.169,0.812,0.4,0.176,0.25,0.78,"C175,R158,M160,Y163",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,7
p.R175L,CTRL-003,PK11000,preclinical,-3.41,-3.2,0.07,0.0,0.07,0.261,0.183,0.854,0.8,0.171,0.249,0.86,"C175,R158,M160,Y163",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003151,8
p.R175L,WM-TP53-01438,WM-TP53-01438,screening,-4.52,-3.6,0.307,0.065,0.307,0.332,0.196,0.779,0.18,0.212,0.245,0.736,"C175,R158,M160,Y163",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000483,9
p.R175L,WM-TP53-05637,WM-TP53-05637,screening,-4.37,-3.22,0.383,0.046,0.383,0.333,0.21,0.716,0.18,0.26,0.245,0.736,"C175,R158,M160,Y163",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000623,10
p.R175L,WM-TP53-03410,WM-TP53-03410,screening,-4.09,-3.2,0.297,0.011,0.297,0.301,0.171,0.79,0.18,0.229,0.222,0.736,"C175,R158,M160,Y163",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000999,11
p.R175L,WM-TP53-05280,WM-TP53-05280,screening,-4.42,-3.76,0.22,0.052,0.22,0.312,0.166,0.699,0.18,0.188,0.211,0.736,"C175,R158,M160,Y163",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000572,12
p.R175L,WM-TP53-00707,WM-TP53-00707,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.157,0.792,0.18,0.24,0.209,0.736,"C175,R158,M160,Y163",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,13
p.R175L,WM-TP53-01795,WM-TP53-01795,screening,-4.17,-3.25,0.307,0.021,0.307,0.308,0.178,0.61,0.18,0.217,0.208,0.736,"C175,R158,M160,Y163",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,14
p.R175L,WM-TP53-02764,WM-TP53-02764,screening,-3.9,-3.2,0.233,0.0,0.233,0.285,0.149,0.781,0.18,0.191,0.205,0.736,"C175,R158,M160,Y163",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001377,15
p.R175L,WM-TP53-07949,WM-TP53-07949,approved,-3.4,-3.2,0.067,0.0,0.067,0.26,0.102,0.651,0.72,0.244,0.199,0.844,"C175,R158,M160,Y163",Pass,False,True,255.6,2.69,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003204,16
p.R175L,WM-TP53-04481,WM-TP53-04481,preclinical,-3.74,-3.2,0.18,0.0,0.18,0.277,0.134,0.711,0.4,0.321,0.195,0.78,"C175,R158,M160,Y163",Pass,False,True,275.4,3.9,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,17
p.R175L,WM-TP53-06623,WM-TP53-06623,screening,-3.89,-3.2,0.23,0.0,0.23,0.284,0.148,0.727,0.18,0.242,0.193,0.736,"C175,R158,M160,Y163",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.0014,18
p.R175L,WM-TP53-03546,WM-TP53-03546,screening,-3.87,-3.2,0.223,0.0,0.223,0.283,0.146,0.757,0.18,0.272,0.193,0.736,"C175,R158,M160,Y163",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,19
p.R175L,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.163,0.599,0.88,0.388,0.192,0.876,"C175,R158,M160,Y163",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,20
p.R175L,WM-TP53-06810,WM-TP53-06810,clinical,-3.95,-3.2,0.25,0.0,0.25,0.287,0.153,0.508,0.62,0.543,0.192,0.824,"C175,R158,M160,Y163",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,21
p.R175L,WM-TP53-04600,WM-TP53-04600,screening,-3.74,-3.2,0.18,0.0,0.18,0.277,0.134,0.791,0.18,0.204,0.192,0.736,"C175,R158,M160,Y163",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,22
p.R175L,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.807,0.62,0.228,0.192,0.824,"C175,R158,M160,Y163",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,23
p.R175L,WM-TP53-06079,WM-TP53-06079,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.136,0.778,0.18,0.257,0.189,0.736,"C175,R158,M160,Y163",Pass,False,True,259.7,2.91,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,24
p.R175L,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.781,0.62,0.256,0.187,0.824,"C175,R158,M160,Y163",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.R175L,WM-TP53-05586,WM-TP53-05586,screening,-3.95,-3.42,0.177,0.0,0.177,0.277,0.133,0.688,0.18,0.172,0.182,0.736,"C175,R158,M160,Y163",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,26
p.R175L,WM-TP53-00367,WM-TP53-00367,screening,-3.85,-3.2,0.217,0.0,0.217,0.283,0.144,0.638,0.18,0.228,0.181,0.736,"C175,R158,M160,Y163",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,27
p.R175L,WM-TP53-01217,WM-TP53-01217,screening,-4.57,-3.83,0.247,0.071,0.247,0.326,0.182,0.509,0.18,0.491,0.178,0.736,"C175,R158,M160,Y163",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000444,28
p.R175L,WM-TP53-06555,WM-TP53-06555,screening,-3.8,-3.2,0.2,0.0,0.2,0.28,0.139,0.719,0.18,0.329,0.178,0.736,"C175,R158,M160,Y163",Pass,False,True,265.4,4.03,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00163,29
p.R175L,WM-TP53-02798,WM-TP53-02798,screening,-3.62,-3.2,0.14,0.0,0.14,0.271,0.123,0.767,0.18,0.225,0.178,0.736,"C175,R158,M160,Y163",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00221,30
p.R175L,WM-TP53-06487,WM-TP53-06487,screening,-3.96,-3.2,0.253,0.0,0.253,0.288,0.154,0.637,0.18,0.382,0.177,0.736,"C175,R158,M160,Y163",Pass,False,True,302.0,4.96,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001244,31
p.R175L,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.709,0.62,0.267,0.177,0.824,"C175,R158,M160,Y163",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.R175L,WM-TP53-05365,WM-TP53-05365,screening,-3.84,-3.2,0.213,0.0,0.213,0.282,0.143,0.694,0.18,0.366,0.175,0.736,"C175,R158,M160,Y163",Pass,False,True,269.4,3.91,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001524,33
p.R175L,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.707,0.62,0.288,0.175,0.824,"C175,R158,M160,Y163",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.R175L,WM-TP53-01676,WM-TP53-01676,clinical,-3.21,-3.2,0.003,0.0,0.003,0.25,0.084,0.708,0.62,0.333,0.173,0.824,"C175,R158,M160,Y163",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,35
p.R175L,WM-TP53-06028,WM-TP53-06028,screening,-3.88,-3.2,0.227,0.0,0.227,0.284,0.147,0.644,0.18,0.374,0.172,0.736,"C175,R158,M160,Y163",Pass,False,True,292.0,4.79,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001424,36
p.R175L,WM-TP53-04056,WM-TP53-04056,screening,-3.48,-3.2,0.093,0.0,0.093,0.264,0.109,0.798,0.18,0.198,0.172,0.736,"C175,R158,M160,Y163",Pass,False,True,244.9,1.84,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002799,37
p.R175L,WM-TP53-02526,WM-TP53-02526,screening,-4.5,-3.8,0.233,0.062,0.233,0.319,0.174,0.505,0.18,0.495,0.17,0.736,"C175,R158,M160,Y163",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.0005,38
p.R175L,WM-TP53-04991,WM-TP53-04991,screening,-3.59,-3.2,0.13,0.0,0.13,0.27,0.12,0.68,0.18,0.202,0.167,0.736,"C175,R158,M160,Y163",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002325,39
p.R175L,WM-TP53-08000,WM-TP53-08000,screening,-3.59,-3.2,0.13,0.0,0.13,0.27,0.12,0.688,0.18,0.224,0.166,0.736,"C175,R158,M160,Y163",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002325,40
p.R175L,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.163,0.609,0.8,0.653,0.164,0.86,"C175,R158,M160,Y163",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.R175L,WM-TP53-05331,WM-TP53-05331,screening,-3.56,-3.2,0.12,0.0,0.12,0.268,0.117,0.688,0.18,0.222,0.164,0.736,"C175,R158,M160,Y163",Pass,False,True,246.1,2.31,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002445,42
p.R175L,WM-TP53-05246,WM-TP53-05246,preclinical,-3.77,-3.22,0.183,0.0,0.183,0.277,0.134,0.507,0.4,0.436,0.162,0.78,"C175,R158,M160,Y163",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,43
p.R175L,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.61,0.62,0.315,0.162,0.824,"C175,R158,M160,Y163",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,44
p.R175L,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.754,0.4,0.267,0.161,0.78,"C175,R158,M160,Y163",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.R175L,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.696,0.4,0.189,0.16,0.78,"C175,R158,M160,Y163",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.R175L,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.695,0.4,0.206,0.159,0.78,"C175,R158,M160,Y163",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.R175L,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.694,0.4,0.203,0.159,0.78,"C175,R158,M160,Y163",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.R175L,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.736,0.4,0.272,0.158,0.78,"C175,R158,M160,Y163",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,49
p.R175L,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.728,0.4,0.262,0.158,0.78,"C175,R158,M160,Y163",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.R175L,WM-TP53-03172,WM-TP53-03172,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.089,0.797,0.18,0.189,0.155,0.736,"C175,R158,M160,Y163",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,51
p.R175L,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.627,0.62,0.426,0.155,0.824,"C175,R158,M160,Y163",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.R175L,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.821,0.18,0.182,0.154,0.736,"C175,R158,M160,Y163",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,53
p.R175L,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.565,0.62,0.339,0.154,0.824,"C175,R158,M160,Y163",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.R175L,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.797,0.18,0.171,0.152,0.736,"C175,R158,M160,Y163",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.R175L,WM-TP53-01625,WM-TP53-01625,screening,-3.39,-3.2,0.063,0.0,0.063,0.259,0.101,0.694,0.18,0.212,0.151,0.736,"C175,R158,M160,Y163",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003259,56
p.R175L,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.785,0.18,0.159,0.151,0.736,"C175,R158,M160,Y163",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.R175L,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.693,0.4,0.292,0.151,0.78,"C175,R158,M160,Y163",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,58
p.R175L,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.804,0.18,0.197,0.15,0.736,"C175,R158,M160,Y163",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.R175L,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.579,0.62,0.419,0.15,0.824,"C175,R158,M160,Y163",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.R175L,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.698,0.4,0.315,0.15,0.78,"C175,R158,M160,Y163",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.R175L,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.812,0.18,0.209,0.15,0.736,"C175,R158,M160,Y163",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,62
p.R175L,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.785,0.18,0.179,0.149,0.736,"C175,R158,M160,Y163",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.R175L,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.651,0.4,0.256,0.149,0.78,"C175,R158,M160,Y163",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.R175L,WM-TP53-06249,WM-TP53-06249,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.088,0.76,0.18,0.217,0.148,0.736,"C175,R158,M160,Y163",Pass,False,True,273.1,2.22,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,65
p.R175L,WM-TP53-05705,WM-TP53-05705,screening,-3.82,-3.31,0.17,0.0,0.17,0.276,0.131,0.601,0.18,0.452,0.147,0.736,"C175,R158,M160,Y163",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001576,66
p.R175L,WM-TP53-07048,WM-TP53-07048,screening,-3.71,-3.2,0.17,0.0,0.17,0.276,0.131,0.592,0.18,0.433,0.147,0.736,"C175,R158,M160,Y163",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.R175L,WM-TP53-00214,WM-TP53-00214,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.095,0.742,0.18,0.267,0.147,0.736,"C175,R158,M160,Y163",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,68
p.R175L,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.756,0.18,0.168,0.147,0.736,"C175,R158,M160,Y163",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.R175L,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.754,0.18,0.159,0.147,0.736,"C175,R158,M160,Y163",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.R175L,WM-TP53-05926,WM-TP53-05926,screening,-3.39,-3.2,0.063,0.0,0.063,0.259,0.101,0.66,0.18,0.224,0.146,0.736,"C175,R158,M160,Y163",Pass,False,True,246.6,2.35,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003259,71
p.R175L,WM-TP53-02475,WM-TP53-02475,screening,-3.31,-3.2,0.037,0.0,0.037,0.256,0.094,0.756,0.18,0.292,0.146,0.736,"C175,R158,M160,Y163",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00373,72
p.R175L,WM-TP53-06538,WM-TP53-06538,screening,-3.27,-3.2,0.023,0.0,0.023,0.253,0.09,0.742,0.18,0.222,0.146,0.736,"C175,R158,M160,Y163",Pass,False,True,246.6,2.32,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003991,73
p.R175L,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.677,0.4,0.34,0.146,0.78,"C175,R158,M160,Y163",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,74
p.R175L,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.767,0.18,0.19,0.146,0.736,"C175,R158,M160,Y163",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.R175L,WM-TP53-06997,WM-TP53-06997,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.095,0.703,0.18,0.237,0.145,0.736,"C175,R158,M160,Y163",Pass,False,True,258.1,2.58,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,76
p.R175L,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.591,0.4,0.221,0.145,0.78,"C175,R158,M160,Y163",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.R175L,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.774,0.18,0.219,0.145,0.736,"C175,R158,M160,Y163",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.R175L,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.528,0.62,0.412,0.144,0.824,"C175,R158,M160,Y163",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.R175L,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.776,0.18,0.234,0.144,0.736,"C175,R158,M160,Y163",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.R175L,WM-TP53-06402,WM-TP53-06402,screening,-3.73,-3.32,0.137,0.0,0.137,0.271,0.122,0.615,0.18,0.418,0.143,0.736,"C175,R158,M160,Y163",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001835,81
p.R175L,WM-TP53-07609,WM-TP53-07609,screening,-3.22,-3.2,0.007,0.0,0.007,0.251,0.085,0.763,0.18,0.245,0.143,0.736,"C175,R158,M160,Y163",Pass,False,True,275.3,2.72,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004343,82
p.R175L,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.546,0.62,0.455,0.143,0.824,"C175,R158,M160,Y163",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.R175L,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.741,0.18,0.188,0.143,0.736,"C175,R158,M160,Y163",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.R175L,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.721,0.18,0.178,0.142,0.736,"C175,R158,M160,Y163",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,Zinc-region structural,Acceptable,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.R175L,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.743,0.18,0.215,0.142,0.736,"C175,R158,M160,Y163",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.R175L,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.75,0.18,0.221,0.142,0.736,"C175,R158,M160,Y163",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.R175L,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.619,0.4,0.304,0.142,0.78,"C175,R158,M160,Y163",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.R175L,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.706,0.18,0.17,0.141,0.736,"C175,R158,M160,Y163",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,89
p.R175L,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.775,0.18,0.264,0.141,0.736,"C175,R158,M160,Y163",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.R175L,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.73,0.18,0.221,0.14,0.736,"C175,R158,M160,Y163",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.R175L,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.734,0.18,0.227,0.14,0.736,"C175,R158,M160,Y163",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.R175L,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.633,0.4,0.339,0.14,0.78,"C175,R158,M160,Y163",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.R175L,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.754,0.18,0.248,0.14,0.736,"C175,R158,M160,Y163",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.R175L,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.744,0.18,0.235,0.14,0.736,"C175,R158,M160,Y163",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.R175L,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.744,0.18,0.232,0.14,0.736,"C175,R158,M160,Y163",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.R175L,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.735,0.18,0.231,0.139,0.736,"C175,R158,M160,Y163",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.R175L,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.733,0.18,0.231,0.139,0.736,"C175,R158,M160,Y163",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.R175L,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.746,0.18,0.249,0.139,0.736,"C175,R158,M160,Y163",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.R175L,WM-TP53-03988,WM-TP53-03988,screening,-3.68,-3.2,0.16,0.0,0.16,0.274,0.128,0.555,0.18,0.463,0.138,0.736,"C175,R158,M160,Y163",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,100
p.R175L,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.731,0.18,0.244,0.138,0.736,"C175,R158,M160,Y163",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,101
p.R175L,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.764,0.18,0.286,0.138,0.736,"C175,R158,M160,Y163",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.R175L,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.741,0.18,0.256,0.138,0.736,"C175,R158,M160,Y163",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.R175L,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.734,0.18,0.244,0.138,0.736,"C175,R158,M160,Y163",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.R175L,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.494,0.62,0.45,0.137,0.824,"C175,R158,M160,Y163",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.R175L,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.737,0.18,0.258,0.137,0.736,"C175,R158,M160,Y163",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.R175L,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.716,0.18,0.249,0.136,0.736,"C175,R158,M160,Y163",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.R175L,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.686,0.18,0.196,0.136,0.736,"C175,R158,M160,Y163",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.R175L,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.736,0.18,0.272,0.136,0.736,"C175,R158,M160,Y163",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.R175L,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.724,0.18,0.275,0.135,0.736,"C175,R158,M160,Y163",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.R175L,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.69,0.18,0.223,0.135,0.736,"C175,R158,M160,Y163",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.R175L,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.727,0.18,0.268,0.135,0.736,"C175,R158,M160,Y163",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.R175L,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.712,0.18,0.272,0.133,0.736,"C175,R158,M160,Y163",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.R175L,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.721,0.18,0.288,0.133,0.736,"C175,R158,M160,Y163",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.R175L,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.598,0.4,0.377,0.133,0.78,"C175,R158,M160,Y163",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.R175L,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.724,0.18,0.288,0.133,0.736,"C175,R158,M160,Y163",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.R175L,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.709,0.18,0.289,0.132,0.736,"C175,R158,M160,Y163",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.R175L,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.705,0.18,0.293,0.131,0.736,"C175,R158,M160,Y163",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.R175L,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.71,0.18,0.299,0.131,0.736,"C175,R158,M160,Y163",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.R175L,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.706,0.18,0.31,0.13,0.736,"C175,R158,M160,Y163",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.R175L,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.671,0.18,0.253,0.13,0.736,"C175,R158,M160,Y163",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.R175L,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.679,0.18,0.279,0.129,0.736,"C175,R158,M160,Y163",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.R175L,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.704,0.18,0.32,0.128,0.736,"C175,R158,M160,Y163",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.R175L,WM-TP53-05739,WM-TP53-05739,screening,-3.48,-3.2,0.093,0.0,0.093,0.264,0.109,0.575,0.18,0.434,0.127,0.736,"C175,R158,M160,Y163",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002799,124
p.R175L,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.679,0.18,0.301,0.127,0.736,"C175,R158,M160,Y163",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.R175L,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.686,0.18,0.307,0.127,0.736,"C175,R158,M160,Y163",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.R175L,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.675,0.18,0.301,0.127,0.736,"C175,R158,M160,Y163",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.R175L,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.7,0.18,0.329,0.127,0.736,"C175,R158,M160,Y163",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.R175L,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.631,0.18,0.235,0.127,0.736,"C175,R158,M160,Y163",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.R175L,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.686,0.18,0.309,0.127,0.736,"C175,R158,M160,Y163",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.R175L,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.579,0.4,0.424,0.127,0.78,"C175,R158,M160,Y163",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.R175L,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.673,0.18,0.309,0.126,0.736,"C175,R158,M160,Y163",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.R175L,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.683,0.18,0.317,0.126,0.736,"C175,R158,M160,Y163",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.R175L,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.624,0.18,0.236,0.126,0.736,"C175,R158,M160,Y163",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.R175L,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.672,0.18,0.303,0.126,0.736,"C175,R158,M160,Y163",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.R175L,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.666,0.18,0.309,0.125,0.736,"C175,R158,M160,Y163",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.R175L,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.676,0.18,0.322,0.125,0.736,"C175,R158,M160,Y163",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.R175L,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.658,0.18,0.298,0.125,0.736,"C175,R158,M160,Y163",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.R175L,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.515,0.4,0.356,0.125,0.78,"C175,R158,M160,Y163",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.R175L,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.681,0.18,0.334,0.125,0.736,"C175,R158,M160,Y163",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.R175L,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.609,0.18,0.228,0.124,0.736,"C175,R158,M160,Y163",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.R175L,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.537,0.4,0.408,0.123,0.78,"C175,R158,M160,Y163",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.R175L,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.599,0.18,0.233,0.123,0.736,"C175,R158,M160,Y163",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,143
p.R175L,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.665,0.18,0.329,0.123,0.736,"C175,R158,M160,Y163",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.R175L,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.662,0.18,0.343,0.122,0.736,"C175,R158,M160,Y163",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.R175L,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.668,0.18,0.35,0.122,0.736,"C175,R158,M160,Y163",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.R175L,WM-TP53-05093,WM-TP53-05093,screening,-3.5,-3.2,0.1,0.0,0.1,0.265,0.111,0.523,0.18,0.447,0.121,0.736,"C175,R158,M160,Y163",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002706,147
p.R175L,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.657,0.18,0.343,0.121,0.736,"C175,R158,M160,Y163",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.R175L,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.65,0.18,0.349,0.12,0.736,"C175,R158,M160,Y163",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.R175L,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.662,0.18,0.364,0.12,0.736,"C175,R158,M160,Y163",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.R175L,WM-TP53-01472,WM-TP53-01472,screening,-3.53,-3.2,0.11,0.0,0.11,0.267,0.114,0.522,0.18,0.496,0.119,0.736,"C175,R158,M160,Y163",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002573,151
p.R175L,WM-TP53-06589,WM-TP53-06589,screening,-3.5,-3.2,0.1,0.0,0.1,0.265,0.111,0.547,0.18,0.506,0.119,0.736,"C175,R158,M160,Y163",Pass,False,True,256.5,2.89,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002706,152
p.R175L,WM-TP53-05671,WM-TP53-05671,screening,-3.4,-3.2,0.067,0.0,0.067,0.26,0.102,0.577,0.18,0.482,0.117,0.736,"C175,R158,M160,Y163",Pass,False,True,248.0,2.49,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003204,153
p.R175L,WM-TP53-03087,WM-TP53-03087,screening,-3.39,-3.2,0.063,0.0,0.063,0.259,0.101,0.59,0.18,0.486,0.117,0.736,"C175,R158,M160,Y163",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003259,154
p.R175L,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.641,0.18,0.373,0.117,0.736,"C175,R158,M160,Y163",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.R175L,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.601,0.18,0.324,0.116,0.736,"C175,R158,M160,Y163",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,156
p.R175L,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.624,0.18,0.356,0.116,0.736,"C175,R158,M160,Y163",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.R175L,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.632,0.18,0.366,0.116,0.736,"C175,R158,M160,Y163",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,158
p.R175L,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.581,0.18,0.307,0.115,0.736,"C175,R158,M160,Y163",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.R175L,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.592,0.18,0.317,0.115,0.736,"C175,R158,M160,Y163",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.R175L,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.629,0.18,0.373,0.115,0.736,"C175,R158,M160,Y163",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,161
p.R175L,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.536,0.4,0.506,0.115,0.78,"C175,R158,M160,Y163",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.R175L,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.631,0.18,0.376,0.115,0.736,"C175,R158,M160,Y163",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,163
p.R175L,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.617,0.18,0.374,0.114,0.736,"C175,R158,M160,Y163",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.R175L,WM-TP53-00299,WM-TP53-00299,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.098,0.581,0.18,0.488,0.113,0.736,"C175,R158,M160,Y163",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,165
p.R175L,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.506,0.4,0.489,0.113,0.78,"C175,R158,M160,Y163",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.R175L,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.603,0.18,0.403,0.11,0.736,"C175,R158,M160,Y163",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.R175L,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.6,0.18,0.402,0.109,0.736,"C175,R158,M160,Y163",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.R175L,WM-TP53-03223,WM-TP53-03223,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.088,0.597,0.18,0.464,0.108,0.736,"C175,R158,M160,Y163",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,169
p.R175L,WM-TP53-02730,WM-TP53-02730,screening,-3.23,-3.2,0.01,0.0,0.01,0.252,0.086,0.572,0.18,0.414,0.108,0.736,"C175,R158,M160,Y163",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00427,170
p.R175L,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.587,0.18,0.418,0.107,0.736,"C175,R158,M160,Y163",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.R175L,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.601,0.18,0.428,0.107,0.736,"C175,R158,M160,Y163",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.R175L,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.572,0.18,0.409,0.106,0.736,"C175,R158,M160,Y163",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.R175L,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.608,0.18,0.459,0.106,0.736,"C175,R158,M160,Y163",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.R175L,WM-TP53-02492,WM-TP53-02492,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.087,0.546,0.18,0.419,0.105,0.736,"C175,R158,M160,Y163",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,175
p.R175L,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.558,0.18,0.411,0.104,0.736,"C175,R158,M160,Y163",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.R175L,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.555,0.18,0.411,0.103,0.736,"C175,R158,M160,Y163",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.R175L,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.572,0.18,0.436,0.103,0.736,"C175,R158,M160,Y163",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.R175L,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.544,0.18,0.411,0.102,0.736,"C175,R158,M160,Y163",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.R175L,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.556,0.18,0.437,0.101,0.736,"C175,R158,M160,Y163",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.R175L,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.559,0.18,0.448,0.101,0.736,"C175,R158,M160,Y163",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.R175L,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.539,0.18,0.416,0.101,0.736,"C175,R158,M160,Y163",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.R175L,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.554,0.18,0.444,0.101,0.736,"C175,R158,M160,Y163",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.R175L,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.527,0.18,0.418,0.099,0.736,"C175,R158,M160,Y163",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.R175L,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.554,0.18,0.458,0.099,0.736,"C175,R158,M160,Y163",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.R175L,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.539,0.18,0.46,0.098,0.736,"C175,R158,M160,Y163",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.R175L,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.532,0.18,0.447,0.098,0.736,"C175,R158,M160,Y163",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.R175L,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.506,0.18,0.42,0.097,0.736,"C175,R158,M160,Y163",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.R175L,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.647,0.18,0.634,0.097,0.736,"C175,R158,M160,Y163",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.R175L,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.65,0.18,0.634,0.097,0.736,"C175,R158,M160,Y163",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.R175L,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.557,0.18,0.521,0.095,0.736,"C175,R158,M160,Y163",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.R175L,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.53,0.18,0.474,0.095,0.736,"C175,R158,M160,Y163",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.R175L,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.513,0.18,0.451,0.095,0.736,"C175,R158,M160,Y163",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.R175L,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.646,0.18,0.647,0.095,0.736,"C175,R158,M160,Y163",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.R175L,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.528,0.18,0.492,0.094,0.736,"C175,R158,M160,Y163",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.R175L,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.553,0.18,0.524,0.094,0.736,"C175,R158,M160,Y163",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.R175L,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.467,0.18,0.409,0.093,0.736,"C175,R158,M160,Y163",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,Zinc-region structural,Watch,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.R175L,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.525,0.18,0.49,0.093,0.736,"C175,R158,M160,Y163",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.R175L,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.503,0.18,0.48,0.092,0.736,"C175,R158,M160,Y163",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.R175L,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.507,0.18,0.483,0.092,0.736,"C175,R158,M160,Y163",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.R175L,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.533,0.18,0.53,0.091,0.736,"C175,R158,M160,Y163",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.R175L,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.482,0.18,0.469,0.09,0.736,"C175,R158,M160,Y163",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.R175L,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.504,0.18,0.504,0.09,0.736,"C175,R158,M160,Y163",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.R175L,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.494,0.18,0.489,0.09,0.736,"C175,R158,M160,Y163",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.R175L,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.509,0.18,0.516,0.089,0.736,"C175,R158,M160,Y163",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.R175L,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.517,0.18,0.529,0.089,0.736,"C175,R158,M160,Y163",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.R175L,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.508,0.18,0.538,0.088,0.736,"C175,R158,M160,Y163",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.R175L,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.508,0.18,0.543,0.087,0.736,"C175,R158,M160,Y163",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.R175L,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.474,0.18,0.544,0.083,0.736,"C175,R158,M160,Y163",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.R175L,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.484,0.18,0.557,0.083,0.736,"C175,R158,M160,Y163",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.R175L,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.461,0.18,0.52,0.083,0.736,"C175,R158,M160,Y163",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.R175L,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.479,0.18,0.574,0.081,0.736,"C175,R158,M160,Y163",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.R175L,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.447,0.18,0.541,0.08,0.736,"C175,R158,M160,Y163",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.R175L,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.469,0.18,0.58,0.079,0.736,"C175,R158,M160,Y163",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.R175L,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.453,0.18,0.58,0.078,0.736,"C175,R158,M160,Y163",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.R175L,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.437,0.18,0.57,0.076,0.736,"C175,R158,M160,Y163",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.R175L,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.537,0.18,0.736,0.075,0.736,"C175,R158,M160,Y163",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.R175L,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.528,0.18,0.739,0.074,0.736,"C175,R158,M160,Y163",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.R175L,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.538,0.18,0.758,0.074,0.736,"C175,R158,M160,Y163",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,In-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.R175L,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.083,0.404,0.18,0.779,0.056,0.636,"C175,R158,M160,Y163",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,Zinc-region structural,Severe liability,Out-of-domain,Evaluate cryptic Zn-region pockets for structural rescue; Zn-site chemistry is a liability,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.R213Q,CTRL-001,PK083,preclinical,-4.44,-3.31,0.377,0.055,0.377,0.337,0.293,0.645,0.8,0.363,0.303,0.86,"C213,R158,M160,Y163",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000553,1
p.R213Q,WM-TP53-00860,WM-TP53-00860,preclinical,-4.21,-3.26,0.317,0.026,0.317,0.312,0.184,0.719,0.4,0.292,0.241,0.78,"C213,R158,M160,Y163",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000816,2
p.R213Q,CTRL-003,PK11000,preclinical,-3.27,-3.2,0.023,0.0,0.023,0.253,0.171,0.854,0.8,0.171,0.237,0.86,"C213,R158,M160,Y163",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003991,3
p.R213Q,WM-TP53-02322,WM-TP53-02322,preclinical,-4.33,-3.78,0.183,0.041,0.183,0.3,0.153,0.812,0.4,0.176,0.235,0.78,"C213,R158,M160,Y163",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000666,4
p.R213Q,WM-TP53-05841,WM-TP53-05841,clinical,-3.83,-3.2,0.21,0.0,0.21,0.281,0.144,0.731,0.62,0.249,0.233,0.824,"C213,R158,M160,Y163",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00155,5
p.R213Q,WM-TP53-07201,WM-TP53-07201,screening,-4.53,-3.73,0.267,0.066,0.267,0.326,0.187,0.758,0.18,0.234,0.231,0.736,"C213,R158,M160,Y163",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000475,6
p.R213Q,WM-TP53-00146,WM-TP53-00146,screening,-4.24,-3.39,0.283,0.03,0.283,0.309,0.177,0.769,0.18,0.273,0.22,0.736,"C213,R158,M160,Y163",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000775,7
p.R213Q,WM-TP53-01438,WM-TP53-01438,screening,-4.28,-3.6,0.227,0.035,0.227,0.303,0.163,0.779,0.18,0.212,0.214,0.736,"C213,R158,M160,Y163",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000725,8
p.R213Q,WM-TP53-05637,WM-TP53-05637,screening,-4.01,-3.22,0.263,0.001,0.263,0.29,0.159,0.716,0.18,0.26,0.199,0.736,"C213,R158,M160,Y163",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001144,9
p.R213Q,WM-TP53-05280,WM-TP53-05280,screening,-4.31,-3.76,0.183,0.039,0.183,0.299,0.152,0.699,0.18,0.188,0.197,0.736,"C213,R158,M160,Y163",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000689,10
p.R213Q,WM-TP53-03410,WM-TP53-03410,screening,-3.82,-3.2,0.207,0.0,0.207,0.281,0.143,0.79,0.18,0.229,0.197,0.736,"C213,R158,M160,Y163",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001576,11
p.R213Q,WM-TP53-02764,WM-TP53-02764,screening,-3.75,-3.2,0.183,0.0,0.183,0.277,0.136,0.781,0.18,0.191,0.193,0.736,"C213,R158,M160,Y163",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001774,12
p.R213Q,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.807,0.62,0.228,0.193,0.824,"C213,R158,M160,Y163",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.R213Q,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.165,0.599,0.88,0.388,0.192,0.876,"C213,R158,M160,Y163",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.R213Q,WM-TP53-01421,WM-TP53-01421,screening,-4.09,-3.2,0.297,0.011,0.297,0.301,0.173,0.561,0.18,0.321,0.188,0.736,"C213,R158,M160,Y163",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000999,15
p.R213Q,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.781,0.62,0.256,0.187,0.824,"C213,R158,M160,Y163",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.R213Q,WM-TP53-01795,WM-TP53-01795,screening,-3.96,-3.25,0.237,0.0,0.237,0.286,0.151,0.61,0.18,0.217,0.183,0.736,"C213,R158,M160,Y163",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001244,17
p.R213Q,WM-TP53-05586,WM-TP53-05586,screening,-3.91,-3.42,0.163,0.0,0.163,0.274,0.131,0.688,0.18,0.172,0.178,0.736,"C213,R158,M160,Y163",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001354,18
p.R213Q,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.709,0.62,0.267,0.178,0.824,"C213,R158,M160,Y163",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.R213Q,WM-TP53-00707,WM-TP53-00707,screening,-3.58,-3.2,0.127,0.0,0.127,0.269,0.121,0.792,0.18,0.24,0.177,0.736,"C213,R158,M160,Y163",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002364,20
p.R213Q,WM-TP53-04600,WM-TP53-04600,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.117,0.791,0.18,0.204,0.176,0.736,"C213,R158,M160,Y163",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,21
p.R213Q,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.707,0.62,0.288,0.176,0.824,"C213,R158,M160,Y163",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,22
p.R213Q,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.708,0.62,0.333,0.172,0.824,"C213,R158,M160,Y163",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,23
p.R213Q,WM-TP53-06810,WM-TP53-06810,clinical,-3.67,-3.2,0.157,0.0,0.157,0.274,0.129,0.508,0.62,0.543,0.17,0.824,"C213,R158,M160,Y163",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002031,24
p.R213Q,WM-TP53-06623,WM-TP53-06623,screening,-3.58,-3.2,0.127,0.0,0.127,0.269,0.121,0.727,0.18,0.242,0.169,0.736,"C213,R158,M160,Y163",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002364,25
p.R213Q,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.77,0.4,0.225,0.166,0.78,"C213,R158,M160,Y163",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,26
p.R213Q,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.165,0.609,0.8,0.653,0.164,0.86,"C213,R158,M160,Y163",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.R213Q,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.61,0.62,0.315,0.162,0.824,"C213,R158,M160,Y163",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.R213Q,WM-TP53-00367,WM-TP53-00367,screening,-3.6,-3.2,0.133,0.0,0.133,0.27,0.122,0.638,0.18,0.228,0.161,0.736,"C213,R158,M160,Y163",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002286,29
p.R213Q,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.754,0.4,0.267,0.161,0.78,"C213,R158,M160,Y163",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.R213Q,WM-TP53-03546,WM-TP53-03546,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.109,0.757,0.18,0.272,0.16,0.736,"C213,R158,M160,Y163",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.R213Q,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.696,0.4,0.189,0.16,0.78,"C213,R158,M160,Y163",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.R213Q,WM-TP53-01217,WM-TP53-01217,screening,-4.42,-3.83,0.197,0.052,0.197,0.308,0.162,0.509,0.18,0.491,0.159,0.736,"C213,R158,M160,Y163",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000572,33
p.R213Q,WM-TP53-05246,WM-TP53-05246,preclinical,-3.72,-3.22,0.167,0.0,0.167,0.275,0.132,0.507,0.4,0.436,0.159,0.78,"C213,R158,M160,Y163",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001866,34
p.R213Q,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.695,0.4,0.206,0.159,0.78,"C213,R158,M160,Y163",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.R213Q,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.694,0.4,0.203,0.159,0.78,"C213,R158,M160,Y163",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,36
p.R213Q,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.736,0.4,0.272,0.158,0.78,"C213,R158,M160,Y163",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.R213Q,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.728,0.4,0.262,0.158,0.78,"C213,R158,M160,Y163",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.R213Q,WM-TP53-04056,WM-TP53-04056,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.093,0.798,0.18,0.198,0.157,0.736,"C213,R158,M160,Y163",Pass,False,True,244.9,1.84,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,39
p.R213Q,WM-TP53-06079,WM-TP53-06079,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.1,0.778,0.18,0.257,0.156,0.736,"C213,R158,M160,Y163",Pass,False,True,259.7,2.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,40
p.R213Q,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.839,0.18,0.178,0.156,0.736,"C213,R158,M160,Y163",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.R213Q,WM-TP53-02798,WM-TP53-02798,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.098,0.767,0.18,0.225,0.155,0.736,"C213,R158,M160,Y163",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,42
p.R213Q,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.565,0.62,0.339,0.155,0.824,"C213,R158,M160,Y163",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.R213Q,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.627,0.62,0.426,0.155,0.824,"C213,R158,M160,Y163",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,44
p.R213Q,WM-TP53-04991,WM-TP53-04991,screening,-3.43,-3.2,0.077,0.0,0.077,0.262,0.107,0.68,0.18,0.202,0.154,0.736,"C213,R158,M160,Y163",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,45
p.R213Q,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.821,0.18,0.182,0.154,0.736,"C213,R158,M160,Y163",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.R213Q,WM-TP53-02526,WM-TP53-02526,screening,-4.36,-3.8,0.187,0.045,0.187,0.303,0.156,0.505,0.18,0.495,0.153,0.736,"C213,R158,M160,Y163",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000633,47
p.R213Q,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.797,0.18,0.171,0.152,0.736,"C213,R158,M160,Y163",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.R213Q,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.693,0.4,0.292,0.152,0.78,"C213,R158,M160,Y163",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,49
p.R213Q,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.804,0.18,0.197,0.151,0.736,"C213,R158,M160,Y163",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.R213Q,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.785,0.18,0.159,0.151,0.736,"C213,R158,M160,Y163",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.R213Q,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.812,0.18,0.209,0.151,0.736,"C213,R158,M160,Y163",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.R213Q,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.579,0.62,0.419,0.15,0.824,"C213,R158,M160,Y163",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,53
p.R213Q,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.698,0.4,0.315,0.15,0.78,"C213,R158,M160,Y163",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.R213Q,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.785,0.18,0.179,0.15,0.736,"C213,R158,M160,Y163",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.R213Q,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.651,0.4,0.256,0.15,0.78,"C213,R158,M160,Y163",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.R213Q,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.797,0.18,0.189,0.15,0.736,"C213,R158,M160,Y163",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.R213Q,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.754,0.18,0.159,0.148,0.736,"C213,R158,M160,Y163",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,58
p.R213Q,WM-TP53-08000,WM-TP53-08000,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.099,0.688,0.18,0.224,0.147,0.736,"C213,R158,M160,Y163",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,59
p.R213Q,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.756,0.18,0.168,0.147,0.736,"C213,R158,M160,Y163",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.R213Q,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.767,0.18,0.19,0.147,0.736,"C213,R158,M160,Y163",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.R213Q,WM-TP53-05705,WM-TP53-05705,screening,-3.81,-3.31,0.167,0.0,0.167,0.275,0.132,0.601,0.18,0.452,0.146,0.736,"C213,R158,M160,Y163",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,62
p.R213Q,WM-TP53-05331,WM-TP53-05331,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.098,0.688,0.18,0.222,0.146,0.736,"C213,R158,M160,Y163",Pass,False,True,246.1,2.31,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,63
p.R213Q,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.677,0.4,0.34,0.146,0.78,"C213,R158,M160,Y163",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.R213Q,WM-TP53-06402,WM-TP53-06402,screening,-3.75,-3.32,0.143,0.0,0.143,0.271,0.125,0.615,0.18,0.418,0.145,0.736,"C213,R158,M160,Y163",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001774,65
p.R213Q,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.591,0.4,0.221,0.145,0.78,"C213,R158,M160,Y163",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.R213Q,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.774,0.18,0.219,0.145,0.736,"C213,R158,M160,Y163",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,67
p.R213Q,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.528,0.62,0.412,0.144,0.824,"C213,R158,M160,Y163",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.R213Q,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.776,0.18,0.234,0.144,0.736,"C213,R158,M160,Y163",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.R213Q,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.741,0.18,0.188,0.144,0.736,"C213,R158,M160,Y163",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.R213Q,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.546,0.62,0.455,0.143,0.824,"C213,R158,M160,Y163",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.R213Q,WM-TP53-07048,WM-TP53-07048,screening,-3.64,-3.2,0.147,0.0,0.147,0.272,0.126,0.592,0.18,0.433,0.142,0.736,"C213,R158,M160,Y163",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002136,72
p.R213Q,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.721,0.18,0.178,0.142,0.736,"C213,R158,M160,Y163",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.R213Q,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.743,0.18,0.215,0.142,0.736,"C213,R158,M160,Y163",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,74
p.R213Q,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.75,0.18,0.221,0.142,0.736,"C213,R158,M160,Y163",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.R213Q,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.775,0.18,0.264,0.142,0.736,"C213,R158,M160,Y163",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.R213Q,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.619,0.4,0.304,0.142,0.78,"C213,R158,M160,Y163",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.R213Q,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.706,0.18,0.17,0.141,0.736,"C213,R158,M160,Y163",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.R213Q,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.633,0.4,0.339,0.141,0.78,"C213,R158,M160,Y163",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.R213Q,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.754,0.18,0.248,0.141,0.736,"C213,R158,M160,Y163",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.R213Q,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.744,0.18,0.232,0.141,0.736,"C213,R158,M160,Y163",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.R213Q,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.73,0.18,0.221,0.14,0.736,"C213,R158,M160,Y163",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.R213Q,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.734,0.18,0.227,0.14,0.736,"C213,R158,M160,Y163",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.R213Q,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.735,0.18,0.231,0.14,0.736,"C213,R158,M160,Y163",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.R213Q,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.744,0.18,0.235,0.14,0.736,"C213,R158,M160,Y163",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.R213Q,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.733,0.18,0.231,0.139,0.736,"C213,R158,M160,Y163",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.R213Q,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.746,0.18,0.249,0.139,0.736,"C213,R158,M160,Y163",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.R213Q,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.764,0.18,0.286,0.139,0.736,"C213,R158,M160,Y163",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.R213Q,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.742,0.18,0.267,0.138,0.736,"C213,R158,M160,Y163",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,89
p.R213Q,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.731,0.18,0.244,0.138,0.736,"C213,R158,M160,Y163",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.R213Q,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.737,0.18,0.258,0.138,0.736,"C213,R158,M160,Y163",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.R213Q,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.741,0.18,0.256,0.138,0.736,"C213,R158,M160,Y163",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.R213Q,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.734,0.18,0.244,0.138,0.736,"C213,R158,M160,Y163",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.R213Q,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.718,0.18,0.224,0.138,0.736,"C213,R158,M160,Y163",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.R213Q,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.494,0.62,0.45,0.137,0.824,"C213,R158,M160,Y163",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.R213Q,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.686,0.18,0.196,0.137,0.736,"C213,R158,M160,Y163",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.R213Q,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.756,0.18,0.292,0.137,0.736,"C213,R158,M160,Y163",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.R213Q,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.716,0.18,0.249,0.136,0.736,"C213,R158,M160,Y163",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.R213Q,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.694,0.18,0.212,0.136,0.736,"C213,R158,M160,Y163",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.R213Q,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.727,0.18,0.268,0.136,0.736,"C213,R158,M160,Y163",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.R213Q,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.736,0.18,0.272,0.136,0.736,"C213,R158,M160,Y163",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,101
p.R213Q,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.724,0.18,0.275,0.135,0.736,"C213,R158,M160,Y163",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.R213Q,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.69,0.18,0.223,0.135,0.736,"C213,R158,M160,Y163",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.R213Q,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.712,0.18,0.272,0.134,0.736,"C213,R158,M160,Y163",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.R213Q,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.598,0.4,0.377,0.134,0.78,"C213,R158,M160,Y163",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.R213Q,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.724,0.18,0.288,0.134,0.736,"C213,R158,M160,Y163",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.R213Q,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.721,0.18,0.288,0.133,0.736,"C213,R158,M160,Y163",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.R213Q,WM-TP53-06555,WM-TP53-06555,screening,-3.23,-3.2,0.01,0.0,0.01,0.252,0.088,0.719,0.18,0.329,0.132,0.736,"C213,R158,M160,Y163",Pass,False,True,265.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00427,108
p.R213Q,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.709,0.18,0.289,0.132,0.736,"C213,R158,M160,Y163",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.R213Q,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.728,0.18,0.318,0.132,0.736,"C213,R158,M160,Y163",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.R213Q,WM-TP53-05365,WM-TP53-05365,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.093,0.694,0.18,0.366,0.131,0.736,"C213,R158,M160,Y163",Pass,False,True,269.4,3.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,111
p.R213Q,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.705,0.18,0.293,0.131,0.736,"C213,R158,M160,Y163",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.R213Q,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.71,0.18,0.299,0.131,0.736,"C213,R158,M160,Y163",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.R213Q,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.706,0.18,0.31,0.13,0.736,"C213,R158,M160,Y163",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.R213Q,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.671,0.18,0.253,0.13,0.736,"C213,R158,M160,Y163",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.R213Q,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.679,0.18,0.279,0.129,0.736,"C213,R158,M160,Y163",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.R213Q,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.704,0.18,0.32,0.129,0.736,"C213,R158,M160,Y163",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.R213Q,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.687,0.18,0.295,0.129,0.736,"C213,R158,M160,Y163",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.R213Q,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.686,0.18,0.307,0.128,0.736,"C213,R158,M160,Y163",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.R213Q,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.7,0.18,0.329,0.128,0.736,"C213,R158,M160,Y163",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.R213Q,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.686,0.18,0.309,0.128,0.736,"C213,R158,M160,Y163",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.R213Q,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.679,0.18,0.301,0.127,0.736,"C213,R158,M160,Y163",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.R213Q,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.683,0.18,0.317,0.127,0.736,"C213,R158,M160,Y163",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.R213Q,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.675,0.18,0.301,0.127,0.736,"C213,R158,M160,Y163",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.R213Q,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.631,0.18,0.235,0.127,0.736,"C213,R158,M160,Y163",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.R213Q,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.579,0.4,0.424,0.127,0.78,"C213,R158,M160,Y163",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.R213Q,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.673,0.18,0.309,0.126,0.736,"C213,R158,M160,Y163",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.R213Q,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.624,0.18,0.236,0.126,0.736,"C213,R158,M160,Y163",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.R213Q,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.672,0.18,0.303,0.126,0.736,"C213,R158,M160,Y163",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.R213Q,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.666,0.18,0.309,0.125,0.736,"C213,R158,M160,Y163",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.R213Q,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.676,0.18,0.322,0.125,0.736,"C213,R158,M160,Y163",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.R213Q,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.609,0.18,0.228,0.125,0.736,"C213,R158,M160,Y163",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.R213Q,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.658,0.18,0.298,0.125,0.736,"C213,R158,M160,Y163",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.R213Q,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.515,0.4,0.356,0.125,0.78,"C213,R158,M160,Y163",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.R213Q,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.681,0.18,0.334,0.125,0.736,"C213,R158,M160,Y163",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.R213Q,WM-TP53-05739,WM-TP53-05739,screening,-3.44,-3.2,0.08,0.0,0.08,0.262,0.107,0.575,0.18,0.434,0.124,0.736,"C213,R158,M160,Y163",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002995,136
p.R213Q,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.537,0.4,0.408,0.124,0.78,"C213,R158,M160,Y163",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.R213Q,WM-TP53-03988,WM-TP53-03988,screening,-3.49,-3.2,0.097,0.0,0.097,0.265,0.112,0.555,0.18,0.463,0.123,0.736,"C213,R158,M160,Y163",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002752,138
p.R213Q,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.599,0.18,0.233,0.123,0.736,"C213,R158,M160,Y163",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.R213Q,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.665,0.18,0.329,0.123,0.736,"C213,R158,M160,Y163",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.R213Q,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.662,0.18,0.343,0.122,0.736,"C213,R158,M160,Y163",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.R213Q,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.668,0.18,0.35,0.122,0.736,"C213,R158,M160,Y163",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.R213Q,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.657,0.18,0.343,0.121,0.736,"C213,R158,M160,Y163",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,143
p.R213Q,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.65,0.18,0.349,0.12,0.736,"C213,R158,M160,Y163",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.R213Q,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.662,0.18,0.364,0.12,0.736,"C213,R158,M160,Y163",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.R213Q,WM-TP53-06487,WM-TP53-06487,screening,-3.23,-3.2,0.01,0.0,0.01,0.252,0.088,0.637,0.18,0.382,0.118,0.736,"C213,R158,M160,Y163",Pass,False,True,302.0,4.96,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00427,146
p.R213Q,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.641,0.18,0.373,0.117,0.736,"C213,R158,M160,Y163",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.R213Q,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.642,0.18,0.38,0.117,0.736,"C213,R158,M160,Y163",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.R213Q,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.601,0.18,0.324,0.116,0.736,"C213,R158,M160,Y163",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.R213Q,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.592,0.18,0.317,0.116,0.736,"C213,R158,M160,Y163",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.R213Q,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.629,0.18,0.373,0.116,0.736,"C213,R158,M160,Y163",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.R213Q,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.624,0.18,0.356,0.116,0.736,"C213,R158,M160,Y163",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.R213Q,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.536,0.4,0.506,0.116,0.78,"C213,R158,M160,Y163",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.R213Q,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.631,0.18,0.376,0.116,0.736,"C213,R158,M160,Y163",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.R213Q,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.632,0.18,0.366,0.116,0.736,"C213,R158,M160,Y163",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.R213Q,WM-TP53-05093,WM-TP53-05093,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.105,0.523,0.18,0.447,0.115,0.736,"C213,R158,M160,Y163",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,156
p.R213Q,WM-TP53-02730,WM-TP53-02730,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.096,0.572,0.18,0.414,0.115,0.736,"C213,R158,M160,Y163",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,157
p.R213Q,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.581,0.18,0.307,0.115,0.736,"C213,R158,M160,Y163",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,158
p.R213Q,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.506,0.4,0.489,0.114,0.78,"C213,R158,M160,Y163",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.R213Q,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.617,0.18,0.374,0.114,0.736,"C213,R158,M160,Y163",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.R213Q,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.634,0.18,0.418,0.113,0.736,"C213,R158,M160,Y163",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,161
p.R213Q,WM-TP53-02492,WM-TP53-02492,screening,-3.3,-3.2,0.033,0.0,0.033,0.255,0.094,0.546,0.18,0.419,0.11,0.736,"C213,R158,M160,Y163",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003794,162
p.R213Q,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.6,0.18,0.402,0.11,0.736,"C213,R158,M160,Y163",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,163
p.R213Q,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.603,0.18,0.403,0.11,0.736,"C213,R158,M160,Y163",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.R213Q,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.601,0.18,0.428,0.108,0.736,"C213,R158,M160,Y163",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.R213Q,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.587,0.18,0.418,0.107,0.736,"C213,R158,M160,Y163",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.R213Q,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.572,0.18,0.409,0.106,0.736,"C213,R158,M160,Y163",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.R213Q,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.608,0.18,0.459,0.106,0.736,"C213,R158,M160,Y163",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.R213Q,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.568,0.18,0.418,0.105,0.736,"C213,R158,M160,Y163",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.R213Q,WM-TP53-00299,WM-TP53-00299,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.089,0.581,0.18,0.488,0.104,0.736,"C213,R158,M160,Y163",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,170
p.R213Q,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.555,0.18,0.411,0.104,0.736,"C213,R158,M160,Y163",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.R213Q,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.558,0.18,0.411,0.104,0.736,"C213,R158,M160,Y163",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.R213Q,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.572,0.18,0.436,0.104,0.736,"C213,R158,M160,Y163",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.R213Q,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.597,0.18,0.464,0.104,0.736,"C213,R158,M160,Y163",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.R213Q,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.556,0.18,0.437,0.102,0.736,"C213,R158,M160,Y163",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.R213Q,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.544,0.18,0.411,0.102,0.736,"C213,R158,M160,Y163",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.R213Q,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.59,0.18,0.486,0.102,0.736,"C213,R158,M160,Y163",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.R213Q,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.559,0.18,0.448,0.101,0.736,"C213,R158,M160,Y163",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.R213Q,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.539,0.18,0.416,0.101,0.736,"C213,R158,M160,Y163",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.R213Q,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.554,0.18,0.444,0.101,0.736,"C213,R158,M160,Y163",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.R213Q,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.527,0.18,0.418,0.1,0.736,"C213,R158,M160,Y163",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.R213Q,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.554,0.18,0.458,0.1,0.736,"C213,R158,M160,Y163",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.R213Q,WM-TP53-01472,WM-TP53-01472,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.093,0.522,0.18,0.496,0.099,0.736,"C213,R158,M160,Y163",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,183
p.R213Q,WM-TP53-06895,WM-TP53-06895,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.086,0.521,0.18,0.435,0.098,0.736,"C213,R158,M160,Y163",Pass,False,True,230.4,0.81,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,184
p.R213Q,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.539,0.18,0.46,0.098,0.736,"C213,R158,M160,Y163",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.R213Q,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.532,0.18,0.447,0.098,0.736,"C213,R158,M160,Y163",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.R213Q,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.506,0.18,0.42,0.097,0.736,"C213,R158,M160,Y163",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.R213Q,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.647,0.18,0.634,0.097,0.736,"C213,R158,M160,Y163",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.R213Q,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.65,0.18,0.634,0.097,0.736,"C213,R158,M160,Y163",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.R213Q,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.53,0.18,0.474,0.096,0.736,"C213,R158,M160,Y163",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.R213Q,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.646,0.18,0.647,0.096,0.736,"C213,R158,M160,Y163",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.R213Q,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.557,0.18,0.521,0.095,0.736,"C213,R158,M160,Y163",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.R213Q,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.513,0.18,0.451,0.095,0.736,"C213,R158,M160,Y163",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.R213Q,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.528,0.18,0.492,0.094,0.736,"C213,R158,M160,Y163",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.R213Q,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.525,0.18,0.49,0.094,0.736,"C213,R158,M160,Y163",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.R213Q,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.553,0.18,0.524,0.094,0.736,"C213,R158,M160,Y163",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.R213Q,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.467,0.18,0.409,0.093,0.736,"C213,R158,M160,Y163",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.R213Q,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.503,0.18,0.48,0.092,0.736,"C213,R158,M160,Y163",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.R213Q,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.507,0.18,0.483,0.092,0.736,"C213,R158,M160,Y163",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.R213Q,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.61,0.18,0.641,0.092,0.736,"C213,R158,M160,Y163",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.R213Q,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.533,0.18,0.53,0.091,0.736,"C213,R158,M160,Y163",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.R213Q,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.482,0.18,0.469,0.09,0.736,"C213,R158,M160,Y163",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.R213Q,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.504,0.18,0.504,0.09,0.736,"C213,R158,M160,Y163",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.R213Q,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.509,0.18,0.516,0.09,0.736,"C213,R158,M160,Y163",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.R213Q,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.517,0.18,0.529,0.09,0.736,"C213,R158,M160,Y163",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.R213Q,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.494,0.18,0.489,0.09,0.736,"C213,R158,M160,Y163",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.R213Q,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.508,0.18,0.538,0.088,0.736,"C213,R158,M160,Y163",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.R213Q,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.508,0.18,0.543,0.087,0.736,"C213,R158,M160,Y163",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.R213Q,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.461,0.18,0.52,0.084,0.736,"C213,R158,M160,Y163",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.R213Q,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.474,0.18,0.544,0.083,0.736,"C213,R158,M160,Y163",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.R213Q,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.484,0.18,0.557,0.083,0.736,"C213,R158,M160,Y163",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.R213Q,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.479,0.18,0.574,0.081,0.736,"C213,R158,M160,Y163",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.R213Q,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.469,0.18,0.58,0.08,0.736,"C213,R158,M160,Y163",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.R213Q,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.447,0.18,0.541,0.08,0.736,"C213,R158,M160,Y163",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.R213Q,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.453,0.18,0.58,0.078,0.736,"C213,R158,M160,Y163",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.R213Q,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.437,0.18,0.57,0.077,0.736,"C213,R158,M160,Y163",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.R213Q,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.537,0.18,0.736,0.075,0.736,"C213,R158,M160,Y163",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.R213Q,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.528,0.18,0.739,0.074,0.736,"C213,R158,M160,Y163",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.R213Q,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.538,0.18,0.758,0.074,0.736,"C213,R158,M160,Y163",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.R213Q,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.085,0.404,0.18,0.779,0.056,0.636,"C213,R158,M160,Y163",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.R249S,CTRL-001,PK083,preclinical,-4.62,-3.31,0.437,0.078,0.437,0.358,0.338,0.645,0.8,0.363,0.329,0.86,"C249,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000408,1
p.R249S,WM-TP53-00860,WM-TP53-00860,preclinical,-4.37,-3.26,0.37,0.046,0.37,0.331,0.226,0.719,0.4,0.292,0.264,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000623,2
p.R249S,CTRL-003,PK11000,preclinical,-3.46,-3.2,0.087,0.0,0.087,0.263,0.208,0.854,0.8,0.171,0.256,0.86,"C249,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,3
p.R249S,WM-TP53-05841,WM-TP53-05841,clinical,-4.04,-3.2,0.28,0.005,0.28,0.295,0.184,0.731,0.62,0.249,0.254,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001087,4
p.R249S,WM-TP53-07201,WM-TP53-07201,screening,-4.67,-3.73,0.313,0.084,0.313,0.343,0.225,0.758,0.18,0.234,0.251,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000375,5
p.R249S,WM-TP53-02322,WM-TP53-02322,preclinical,-4.39,-3.78,0.203,0.049,0.203,0.307,0.18,0.812,0.4,0.176,0.245,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000602,6
p.R249S,WM-TP53-00146,WM-TP53-00146,screening,-4.34,-3.39,0.317,0.042,0.317,0.321,0.21,0.769,0.18,0.273,0.236,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000655,7
p.R249S,WM-TP53-01438,WM-TP53-01438,screening,-4.37,-3.6,0.257,0.046,0.257,0.314,0.194,0.779,0.18,0.212,0.228,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000623,8
p.R249S,WM-TP53-01421,WM-TP53-01421,screening,-4.27,-3.2,0.357,0.034,0.357,0.322,0.217,0.561,0.18,0.321,0.213,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,9
p.R249S,WM-TP53-05637,WM-TP53-05637,screening,-4.09,-3.22,0.29,0.011,0.29,0.3,0.189,0.716,0.18,0.26,0.212,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000999,10
p.R249S,WM-TP53-02764,WM-TP53-02764,screening,-3.9,-3.2,0.233,0.0,0.233,0.285,0.169,0.781,0.18,0.191,0.208,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001377,11
p.R249S,WM-TP53-05280,WM-TP53-05280,screening,-4.36,-3.76,0.2,0.045,0.2,0.305,0.178,0.699,0.18,0.188,0.206,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000633,12
p.R249S,WM-TP53-01795,WM-TP53-01795,screening,-4.13,-3.25,0.293,0.016,0.293,0.303,0.192,0.61,0.18,0.217,0.205,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000934,13
p.R249S,WM-TP53-03410,WM-TP53-03410,screening,-3.88,-3.2,0.227,0.0,0.227,0.284,0.167,0.79,0.18,0.229,0.204,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001424,14
p.R249S,WM-TP53-00707,WM-TP53-00707,screening,-3.83,-3.2,0.21,0.0,0.21,0.281,0.162,0.792,0.18,0.24,0.199,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00155,15
p.R249S,WM-TP53-07949,WM-TP53-07949,approved,-3.35,-3.2,0.05,0.0,0.05,0.258,0.118,0.651,0.72,0.244,0.197,0.844,"C249,R158,M160,Y163,R273,R249",Pass,False,True,255.6,2.69,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,16
p.R249S,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.807,0.62,0.228,0.195,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,17
p.R249S,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.183,0.599,0.88,0.388,0.194,0.876,"C249,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,18
p.R249S,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.781,0.62,0.256,0.19,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.R249S,WM-TP53-04600,WM-TP53-04600,screening,-3.67,-3.2,0.157,0.0,0.157,0.274,0.148,0.791,0.18,0.204,0.189,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002031,20
p.R249S,WM-TP53-06623,WM-TP53-06623,screening,-3.79,-3.2,0.197,0.0,0.197,0.28,0.159,0.727,0.18,0.242,0.188,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001658,21
p.R249S,WM-TP53-05586,WM-TP53-05586,screening,-3.96,-3.42,0.18,0.0,0.18,0.277,0.154,0.688,0.18,0.172,0.185,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001244,22
p.R249S,WM-TP53-00367,WM-TP53-00367,screening,-3.81,-3.2,0.203,0.0,0.203,0.28,0.16,0.638,0.18,0.228,0.18,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,23
p.R249S,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.709,0.62,0.267,0.18,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.R249S,WM-TP53-03546,WM-TP53-03546,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.146,0.757,0.18,0.272,0.179,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,25
p.R249S,WM-TP53-06079,WM-TP53-06079,screening,-3.61,-3.2,0.137,0.0,0.137,0.271,0.142,0.778,0.18,0.257,0.179,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,259.7,2.91,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002247,26
p.R249S,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.707,0.62,0.288,0.178,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.R249S,WM-TP53-04481,WM-TP53-04481,preclinical,-3.48,-3.2,0.093,0.0,0.093,0.264,0.13,0.711,0.4,0.321,0.177,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,275.4,3.9,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002799,28
p.R249S,WM-TP53-06810,WM-TP53-06810,clinical,-3.72,-3.2,0.173,0.0,0.173,0.276,0.152,0.508,0.62,0.543,0.176,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001866,29
p.R249S,WM-TP53-04056,WM-TP53-04056,screening,-3.49,-3.2,0.097,0.0,0.097,0.265,0.131,0.798,0.18,0.198,0.176,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,244.9,1.84,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002752,30
p.R249S,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.708,0.62,0.333,0.175,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,31
p.R249S,WM-TP53-02798,WM-TP53-02798,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.135,0.767,0.18,0.225,0.174,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,32
p.R249S,WM-TP53-04991,WM-TP53-04991,screening,-3.6,-3.2,0.133,0.0,0.133,0.27,0.141,0.68,0.18,0.202,0.17,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002286,33
p.R249S,WM-TP53-01217,WM-TP53-01217,screening,-4.48,-3.83,0.217,0.06,0.217,0.316,0.189,0.509,0.18,0.491,0.169,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000517,34
p.R249S,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.183,0.609,0.8,0.653,0.166,0.86,"C249,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.R249S,WM-TP53-05246,WM-TP53-05246,preclinical,-3.78,-3.22,0.187,0.0,0.187,0.278,0.156,0.507,0.4,0.436,0.166,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001686,36
p.R249S,WM-TP53-05331,WM-TP53-05331,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.135,0.688,0.18,0.222,0.165,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,246.1,2.31,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,37
p.R249S,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.61,0.62,0.315,0.165,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.R249S,WM-TP53-08000,WM-TP53-08000,screening,-3.53,-3.2,0.11,0.0,0.11,0.267,0.134,0.688,0.18,0.224,0.164,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002573,39
p.R249S,WM-TP53-03172,WM-TP53-03172,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.117,0.797,0.18,0.189,0.164,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,40
p.R249S,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.754,0.4,0.267,0.164,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.R249S,WM-TP53-02526,WM-TP53-02526,screening,-4.42,-3.8,0.207,0.052,0.207,0.31,0.183,0.505,0.18,0.495,0.163,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000572,42
p.R249S,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.696,0.4,0.189,0.163,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.R249S,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.694,0.4,0.203,0.162,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,44
p.R249S,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.695,0.4,0.206,0.161,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.R249S,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.736,0.4,0.272,0.161,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.R249S,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.728,0.4,0.262,0.161,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.R249S,WM-TP53-05705,WM-TP53-05705,screening,-3.92,-3.31,0.203,0.0,0.203,0.28,0.16,0.601,0.18,0.452,0.158,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001331,48
p.R249S,WM-TP53-07048,WM-TP53-07048,screening,-3.81,-3.2,0.203,0.0,0.203,0.28,0.16,0.592,0.18,0.433,0.158,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,49
p.R249S,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.627,0.62,0.426,0.158,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.R249S,WM-TP53-06555,WM-TP53-06555,screening,-3.5,-3.2,0.1,0.0,0.1,0.265,0.132,0.719,0.18,0.329,0.157,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,265.4,4.03,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002706,51
p.R249S,WM-TP53-01982,WM-TP53-01982,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.108,0.785,0.18,0.179,0.157,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,52
p.R249S,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.821,0.18,0.182,0.157,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,53
p.R249S,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.565,0.62,0.339,0.157,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.R249S,WM-TP53-05365,WM-TP53-05365,screening,-3.57,-3.2,0.123,0.0,0.123,0.268,0.138,0.694,0.18,0.366,0.156,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,269.4,3.91,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002405,55
p.R249S,WM-TP53-06249,WM-TP53-06249,screening,-3.31,-3.2,0.037,0.0,0.037,0.256,0.114,0.76,0.18,0.217,0.155,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,273.1,2.22,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00373,56
p.R249S,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.797,0.18,0.171,0.155,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.R249S,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.785,0.18,0.159,0.154,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,58
p.R249S,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.693,0.4,0.292,0.154,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.R249S,WM-TP53-01625,WM-TP53-01625,screening,-3.38,-3.2,0.06,0.0,0.06,0.259,0.12,0.694,0.18,0.212,0.153,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003314,60
p.R249S,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.804,0.18,0.197,0.153,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.R249S,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.579,0.62,0.419,0.153,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,62
p.R249S,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.698,0.4,0.315,0.153,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.R249S,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.812,0.18,0.209,0.153,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.R249S,WM-TP53-06402,WM-TP53-06402,screening,-3.8,-3.32,0.16,0.0,0.16,0.274,0.148,0.615,0.18,0.418,0.152,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00163,65
p.R249S,WM-TP53-06487,WM-TP53-06487,screening,-3.62,-3.2,0.14,0.0,0.14,0.271,0.143,0.637,0.18,0.382,0.152,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,302.0,4.96,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00221,66
p.R249S,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.651,0.4,0.256,0.152,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,67
p.R249S,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.756,0.18,0.168,0.15,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.R249S,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.754,0.18,0.159,0.15,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.R249S,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.677,0.4,0.34,0.149,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.R249S,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.767,0.18,0.19,0.149,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.R249S,WM-TP53-05926,WM-TP53-05926,screening,-3.37,-3.2,0.057,0.0,0.057,0.259,0.12,0.66,0.18,0.224,0.148,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,246.6,2.35,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003371,72
p.R249S,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.591,0.4,0.221,0.148,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.R249S,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.774,0.18,0.219,0.148,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,74
p.R249S,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.528,0.62,0.412,0.147,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.R249S,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.776,0.18,0.234,0.147,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.R249S,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.546,0.62,0.455,0.146,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.R249S,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.741,0.18,0.188,0.146,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.R249S,WM-TP53-03988,WM-TP53-03988,screening,-3.73,-3.2,0.177,0.0,0.177,0.277,0.153,0.555,0.18,0.463,0.145,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001835,79
p.R249S,WM-TP53-06997,WM-TP53-06997,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.112,0.703,0.18,0.237,0.145,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,258.1,2.58,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,80
p.R249S,WM-TP53-00214,WM-TP53-00214,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.109,0.742,0.18,0.267,0.145,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,81
p.R249S,WM-TP53-06538,WM-TP53-06538,screening,-3.22,-3.2,0.007,0.0,0.007,0.251,0.105,0.742,0.18,0.222,0.145,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,246.6,2.32,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004343,82
p.R249S,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.721,0.18,0.178,0.145,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.R249S,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.743,0.18,0.215,0.145,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.R249S,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.75,0.18,0.221,0.145,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.R249S,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.619,0.4,0.304,0.145,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.R249S,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.706,0.18,0.17,0.144,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.R249S,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.775,0.18,0.264,0.144,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.R249S,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.633,0.4,0.339,0.143,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,89
p.R249S,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.754,0.18,0.248,0.143,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.R249S,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.744,0.18,0.235,0.143,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.R249S,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.744,0.18,0.232,0.143,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.R249S,WM-TP53-06028,WM-TP53-06028,screening,-3.47,-3.2,0.09,0.0,0.09,0.264,0.129,0.644,0.18,0.374,0.142,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,292.0,4.79,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002847,93
p.R249S,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.73,0.18,0.221,0.142,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.R249S,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.734,0.18,0.227,0.142,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.R249S,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.735,0.18,0.231,0.142,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.R249S,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.733,0.18,0.231,0.142,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.R249S,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.746,0.18,0.249,0.142,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.R249S,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.731,0.18,0.244,0.141,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.R249S,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.764,0.18,0.286,0.141,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.R249S,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.741,0.18,0.256,0.141,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,101
p.R249S,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.734,0.18,0.244,0.141,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.R249S,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.494,0.62,0.45,0.14,0.824,"C249,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.R249S,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.756,0.18,0.292,0.14,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.R249S,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.737,0.18,0.258,0.14,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.R249S,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.716,0.18,0.249,0.139,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.R249S,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.686,0.18,0.196,0.139,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.R249S,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.736,0.18,0.272,0.139,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.R249S,WM-TP53-05739,WM-TP53-05739,screening,-3.59,-3.2,0.13,0.0,0.13,0.27,0.14,0.575,0.18,0.434,0.138,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002325,109
p.R249S,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.69,0.18,0.223,0.138,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.R249S,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.727,0.18,0.268,0.138,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.R249S,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.724,0.18,0.275,0.137,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.R249S,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.712,0.18,0.272,0.136,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.R249S,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.721,0.18,0.288,0.136,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.R249S,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.598,0.4,0.377,0.136,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.R249S,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.724,0.18,0.288,0.136,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.R249S,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.709,0.18,0.289,0.135,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.R249S,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.705,0.18,0.293,0.134,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.R249S,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.71,0.18,0.299,0.134,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.R249S,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.671,0.18,0.253,0.133,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.R249S,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.706,0.18,0.31,0.132,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.R249S,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.679,0.18,0.279,0.132,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.R249S,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.704,0.18,0.32,0.131,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.R249S,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.679,0.18,0.301,0.13,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.R249S,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.686,0.18,0.307,0.13,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.R249S,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.7,0.18,0.329,0.13,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.R249S,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.686,0.18,0.309,0.13,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.R249S,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.579,0.4,0.424,0.13,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.R249S,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.673,0.18,0.309,0.129,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.R249S,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.683,0.18,0.317,0.129,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.R249S,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.624,0.18,0.236,0.129,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.R249S,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.675,0.18,0.301,0.129,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.R249S,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.672,0.18,0.303,0.129,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.R249S,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.631,0.18,0.235,0.129,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.R249S,WM-TP53-05093,WM-TP53-05093,screening,-3.55,-3.2,0.117,0.0,0.117,0.268,0.136,0.523,0.18,0.447,0.128,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002487,135
p.R249S,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.666,0.18,0.309,0.128,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.R249S,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.676,0.18,0.322,0.128,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.R249S,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.658,0.18,0.298,0.128,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.R249S,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.515,0.4,0.356,0.128,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.R249S,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.681,0.18,0.334,0.128,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.R249S,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.609,0.18,0.228,0.127,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.R249S,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.537,0.4,0.408,0.126,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.R249S,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.599,0.18,0.233,0.126,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,143
p.R249S,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.665,0.18,0.329,0.126,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.R249S,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.662,0.18,0.343,0.125,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.R249S,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.668,0.18,0.35,0.125,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.R249S,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.657,0.18,0.343,0.124,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.R249S,WM-TP53-02730,WM-TP53-02730,screening,-3.38,-3.2,0.06,0.0,0.06,0.259,0.12,0.572,0.18,0.414,0.123,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003314,148
p.R249S,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.65,0.18,0.349,0.123,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.R249S,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.662,0.18,0.364,0.123,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.R249S,WM-TP53-00299,WM-TP53-00299,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.124,0.581,0.18,0.488,0.121,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,151
p.R249S,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.641,0.18,0.373,0.12,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.R249S,WM-TP53-02492,WM-TP53-02492,screening,-3.38,-3.2,0.06,0.0,0.06,0.259,0.12,0.546,0.18,0.419,0.119,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003314,153
p.R249S,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.601,0.18,0.324,0.119,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.R249S,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.624,0.18,0.356,0.119,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.R249S,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.632,0.18,0.366,0.119,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,156
p.R249S,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.581,0.18,0.307,0.118,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.R249S,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.592,0.18,0.317,0.118,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,158
p.R249S,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.629,0.18,0.373,0.118,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.R249S,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.536,0.4,0.506,0.118,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.R249S,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.631,0.18,0.376,0.118,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,161
p.R249S,WM-TP53-05671,WM-TP53-05671,screening,-3.37,-3.2,0.057,0.0,0.057,0.259,0.12,0.577,0.18,0.482,0.117,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.49,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003371,162
p.R249S,WM-TP53-03087,WM-TP53-03087,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.118,0.59,0.18,0.486,0.117,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,163
p.R249S,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.617,0.18,0.374,0.117,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.R249S,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.506,0.4,0.489,0.116,0.78,"C249,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.R249S,WM-TP53-01472,WM-TP53-01472,screening,-3.44,-3.2,0.08,0.0,0.08,0.262,0.126,0.522,0.18,0.496,0.115,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002995,166
p.R249S,WM-TP53-06589,WM-TP53-06589,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.124,0.547,0.18,0.506,0.115,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,256.5,2.89,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,167
p.R249S,WM-TP53-06895,WM-TP53-06895,screening,-3.38,-3.2,0.06,0.0,0.06,0.259,0.12,0.521,0.18,0.435,0.115,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,230.4,0.81,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003314,168
p.R249S,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.603,0.18,0.403,0.113,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.R249S,WM-TP53-03223,WM-TP53-03223,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.109,0.597,0.18,0.464,0.112,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,170
p.R249S,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.6,0.18,0.402,0.112,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.R249S,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.587,0.18,0.418,0.11,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.R249S,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.601,0.18,0.428,0.11,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.R249S,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.608,0.18,0.459,0.109,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.R249S,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.572,0.18,0.409,0.108,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.R249S,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.558,0.18,0.411,0.107,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.R249S,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.555,0.18,0.411,0.106,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.R249S,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.572,0.18,0.436,0.106,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.R249S,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.544,0.18,0.411,0.105,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.R249S,WM-TP53-02917,WM-TP53-02917,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.104,0.554,0.18,0.444,0.104,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,180
p.R249S,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.556,0.18,0.437,0.104,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.R249S,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.559,0.18,0.448,0.104,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.R249S,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.539,0.18,0.416,0.104,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.R249S,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.527,0.18,0.418,0.102,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.R249S,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.554,0.18,0.458,0.102,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.R249S,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.532,0.18,0.447,0.101,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.R249S,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.539,0.18,0.46,0.1,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.R249S,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.506,0.18,0.42,0.1,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.R249S,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.65,0.18,0.634,0.1,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.R249S,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.647,0.18,0.634,0.099,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.R249S,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.557,0.18,0.521,0.098,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.R249S,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.53,0.18,0.474,0.098,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.R249S,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.513,0.18,0.451,0.098,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.R249S,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.646,0.18,0.647,0.098,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.R249S,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.528,0.18,0.492,0.097,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.R249S,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.553,0.18,0.524,0.097,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.R249S,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.467,0.18,0.409,0.096,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.R249S,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.525,0.18,0.49,0.096,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.R249S,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.503,0.18,0.48,0.095,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.R249S,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.507,0.18,0.483,0.095,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.R249S,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.533,0.18,0.53,0.094,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.R249S,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.482,0.18,0.469,0.093,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.R249S,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.504,0.18,0.504,0.093,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.R249S,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.494,0.18,0.489,0.093,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.R249S,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.509,0.18,0.516,0.092,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.R249S,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.517,0.18,0.529,0.092,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.R249S,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.508,0.18,0.543,0.09,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.R249S,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.508,0.18,0.538,0.09,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.R249S,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.474,0.18,0.544,0.086,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.R249S,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.484,0.18,0.557,0.086,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.R249S,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.461,0.18,0.52,0.086,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.R249S,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.479,0.18,0.574,0.084,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.R249S,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.447,0.18,0.541,0.083,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.R249S,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.469,0.18,0.58,0.082,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.R249S,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.453,0.18,0.58,0.081,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.R249S,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.437,0.18,0.57,0.079,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.R249S,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.537,0.18,0.736,0.078,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.R249S,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.528,0.18,0.739,0.077,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.R249S,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.538,0.18,0.758,0.076,0.736,"C249,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.R249S,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.104,0.404,0.18,0.779,0.059,0.636,"C249,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Specialized DNA-contact route,Structural / cavity or core,Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.R273C,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.854,0.8,0.171,0.212,0.89,"C273,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,known-ligand-control,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,1
p.R273C,CTRL-001,PK083,preclinical,-3.7,-3.31,0.13,0.0,0.13,0.27,0.047,0.645,0.8,0.363,0.202,0.89,"C273,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.00193,2
p.R273C,WM-TP53-02322,WM-TP53-02322,preclinical,-4.18,-3.78,0.133,0.022,0.133,0.282,0.02,0.812,0.4,0.176,0.2,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,unremarkable,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.000858,3
p.R273C,WM-TP53-05841,WM-TP53-05841,clinical,-3.44,-3.2,0.08,0.0,0.08,0.262,0.02,0.731,0.62,0.249,0.189,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.002995,4
p.R273C,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.807,0.62,0.228,0.183,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,5
p.R273C,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.781,0.62,0.256,0.178,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,repurposing-eligible,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,6
p.R273C,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.599,0.88,0.388,0.172,0.906,"C273,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,7
p.R273C,WM-TP53-00860,WM-TP53-00860,preclinical,-3.65,-3.26,0.13,0.0,0.13,0.27,0.02,0.719,0.4,0.292,0.172,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.002101,8
p.R273C,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.709,0.62,0.267,0.169,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,9
p.R273C,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.707,0.62,0.288,0.167,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,10
p.R273C,WM-TP53-07201,WM-TP53-07201,screening,-4.13,-3.73,0.133,0.016,0.133,0.279,0.02,0.758,0.18,0.234,0.165,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.000934,11
p.R273C,WM-TP53-05280,WM-TP53-05280,screening,-4.17,-3.76,0.137,0.021,0.137,0.282,0.02,0.699,0.18,0.188,0.164,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.000873,12
p.R273C,WM-TP53-01438,WM-TP53-01438,screening,-4.0,-3.6,0.133,0.0,0.133,0.27,0.02,0.779,0.18,0.212,0.164,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.001163,13
p.R273C,WM-TP53-02764,WM-TP53-02764,screening,-3.55,-3.2,0.117,0.0,0.117,0.268,0.02,0.781,0.18,0.191,0.163,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.002487,14
p.R273C,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.708,0.62,0.333,0.163,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,15
p.R273C,WM-TP53-05586,WM-TP53-05586,screening,-3.84,-3.42,0.14,0.0,0.14,0.271,0.02,0.688,0.18,0.172,0.158,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.001524,16
p.R273C,WM-TP53-00146,WM-TP53-00146,screening,-3.78,-3.39,0.13,0.0,0.13,0.27,0.02,0.769,0.18,0.273,0.158,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.001686,17
p.R273C,WM-TP53-03410,WM-TP53-03410,screening,-3.51,-3.2,0.103,0.0,0.103,0.265,0.02,0.79,0.18,0.229,0.158,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.002661,18
p.R273C,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.77,0.4,0.225,0.157,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,19
p.R273C,WM-TP53-05637,WM-TP53-05637,screening,-3.61,-3.22,0.13,0.0,0.13,0.27,0.02,0.716,0.18,0.26,0.153,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.002247,20
p.R273C,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.61,0.62,0.315,0.153,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,21
p.R273C,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.754,0.4,0.267,0.152,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,22
p.R273C,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.696,0.4,0.189,0.151,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,unremarkable,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,23
p.R273C,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.695,0.4,0.206,0.15,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,24
p.R273C,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.694,0.4,0.203,0.15,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,25
p.R273C,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.736,0.4,0.272,0.149,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,26
p.R273C,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.728,0.4,0.262,0.149,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,27
p.R273C,WM-TP53-01795,WM-TP53-01795,screening,-3.69,-3.25,0.147,0.0,0.147,0.272,0.02,0.61,0.18,0.217,0.147,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.001963,28
p.R273C,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.839,0.18,0.178,0.147,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,29
p.R273C,WM-TP53-04600,WM-TP53-04600,screening,-3.3,-3.2,0.033,0.0,0.033,0.255,0.02,0.791,0.18,0.204,0.146,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.003794,30
p.R273C,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.627,0.62,0.426,0.146,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,31
p.R273C,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.821,0.18,0.182,0.145,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,32
p.R273C,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.565,0.62,0.339,0.145,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,33
p.R273C,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.609,0.8,0.653,0.144,0.89,"C273,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,34
p.R273C,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.797,0.18,0.171,0.143,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,35
p.R273C,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.693,0.4,0.292,0.143,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,36
p.R273C,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.804,0.18,0.197,0.142,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,37
p.R273C,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.785,0.18,0.159,0.142,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,38
p.R273C,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.812,0.18,0.209,0.142,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,39
p.R273C,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.579,0.62,0.419,0.141,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,40
p.R273C,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.698,0.4,0.315,0.141,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,41
p.R273C,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.785,0.18,0.179,0.141,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,42
p.R273C,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.797,0.18,0.189,0.141,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,43
p.R273C,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.651,0.4,0.256,0.14,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,unremarkable,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,44
p.R273C,WM-TP53-03359,WM-TP53-03359,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.785,0.18,0.185,0.14,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,287.6,1.52,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,45
p.R273C,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.754,0.18,0.159,0.139,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,46
p.R273C,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.756,0.18,0.168,0.138,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,47
p.R273C,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.767,0.18,0.19,0.138,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,48
p.R273C,WM-TP53-05246,WM-TP53-05246,preclinical,-3.64,-3.22,0.14,0.0,0.14,0.271,0.02,0.507,0.4,0.436,0.137,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.002136,49
p.R273C,WM-TP53-00707,WM-TP53-00707,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.792,0.18,0.24,0.137,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,50
p.R273C,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.677,0.4,0.34,0.137,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,51
p.R273C,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.591,0.4,0.221,0.136,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,52
p.R273C,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.774,0.18,0.219,0.136,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,53
p.R273C,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.76,0.18,0.194,0.136,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,377.3,1.73,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,54
p.R273C,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.528,0.62,0.412,0.135,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,55
p.R273C,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.776,0.18,0.234,0.135,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,56
p.R273C,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.741,0.18,0.188,0.135,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,57
p.R273C,WM-TP53-02798,WM-TP53-02798,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.767,0.18,0.225,0.135,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,58
p.R273C,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.546,0.62,0.455,0.134,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,59
p.R273C,WM-TP53-06810,WM-TP53-06810,clinical,-3.36,-3.2,0.053,0.0,0.053,0.258,0.02,0.508,0.62,0.543,0.133,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.003428,60
p.R273C,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.721,0.18,0.178,0.133,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,61
p.R273C,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.743,0.18,0.215,0.133,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,62
p.R273C,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.75,0.18,0.221,0.133,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,63
p.R273C,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.775,0.18,0.264,0.133,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,64
p.R273C,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.619,0.4,0.304,0.133,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,65
p.R273C,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.706,0.18,0.17,0.132,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,66
p.R273C,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.633,0.4,0.339,0.132,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,67
p.R273C,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.744,0.18,0.232,0.132,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,68
p.R273C,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.73,0.18,0.221,0.131,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,69
p.R273C,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.734,0.18,0.227,0.131,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,70
p.R273C,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.735,0.18,0.231,0.131,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,71
p.R273C,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.754,0.18,0.248,0.131,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,72
p.R273C,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.744,0.18,0.235,0.131,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,73
p.R273C,WM-TP53-06402,WM-TP53-06402,screening,-3.74,-3.32,0.14,0.0,0.14,0.271,0.02,0.615,0.18,0.418,0.13,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.001804,74
p.R273C,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.733,0.18,0.231,0.13,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,75
p.R273C,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.746,0.18,0.249,0.13,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,76
p.R273C,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.764,0.18,0.286,0.13,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,77
p.R273C,WM-TP53-06623,WM-TP53-06623,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.02,0.727,0.18,0.242,0.129,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004417,78
p.R273C,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.731,0.18,0.244,0.129,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,79
p.R273C,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.737,0.18,0.258,0.129,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,80
p.R273C,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.741,0.18,0.256,0.129,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,81
p.R273C,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.734,0.18,0.244,0.129,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,82
p.R273C,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.718,0.18,0.224,0.129,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,389.6,2.36,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,83
p.R273C,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.742,0.18,0.267,0.128,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,84
p.R273C,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.494,0.62,0.45,0.128,0.854,"C273,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,85
p.R273C,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.756,0.18,0.292,0.128,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,86
p.R273C,WM-TP53-05705,WM-TP53-05705,screening,-3.75,-3.31,0.147,0.0,0.147,0.272,0.02,0.601,0.18,0.452,0.127,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.001774,87
p.R273C,WM-TP53-04991,WM-TP53-04991,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.02,0.68,0.18,0.202,0.127,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004417,88
p.R273C,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.716,0.18,0.249,0.127,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,89
p.R273C,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.686,0.18,0.196,0.127,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,90
p.R273C,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.694,0.18,0.212,0.127,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Specialized DNA-contact route,DNA-contact,Acceptable,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,low-external-evidence,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,91
p.R273C,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.727,0.18,0.268,0.127,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,92
p.R273C,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.736,0.18,0.272,0.127,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,93
p.R273C,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.724,0.18,0.275,0.126,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,94
p.R273C,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.69,0.18,0.223,0.126,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,95
p.R273C,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.724,0.18,0.288,0.125,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,96
p.R273C,WM-TP53-01421,WM-TP53-01421,screening,-3.52,-3.2,0.107,0.0,0.107,0.266,0.02,0.561,0.18,0.321,0.124,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.002616,97
p.R273C,WM-TP53-00367,WM-TP53-00367,screening,-3.27,-3.2,0.023,0.0,0.023,0.253,0.02,0.638,0.18,0.228,0.124,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.003991,98
p.R273C,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.712,0.18,0.272,0.124,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,99
p.R273C,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.721,0.18,0.288,0.124,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,100
p.R273C,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.598,0.4,0.377,0.124,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,101
p.R273C,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.709,0.18,0.289,0.123,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,102
p.R273C,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.728,0.18,0.318,0.123,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,103
p.R273C,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.705,0.18,0.293,0.122,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,104
p.R273C,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.71,0.18,0.299,0.122,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,105
p.R273C,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.706,0.18,0.31,0.121,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,106
p.R273C,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.671,0.18,0.253,0.121,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,107
p.R273C,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.684,0.18,0.274,0.121,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,429.0,3.18,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,108
p.R273C,WM-TP53-01217,WM-TP53-01217,screening,-4.24,-3.83,0.137,0.03,0.137,0.287,0.02,0.509,0.18,0.491,0.12,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.000775,109
p.R273C,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.679,0.18,0.279,0.12,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,110
p.R273C,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.704,0.18,0.32,0.12,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,111
p.R273C,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.687,0.18,0.295,0.12,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,112
p.R273C,WM-TP53-07048,WM-TP53-07048,screening,-3.52,-3.2,0.107,0.0,0.107,0.266,0.02,0.592,0.18,0.433,0.119,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.002616,113
p.R273C,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.686,0.18,0.307,0.119,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,114
p.R273C,WM-TP53-02526,WM-TP53-02526,screening,-4.21,-3.8,0.137,0.026,0.137,0.285,0.02,0.505,0.18,0.495,0.118,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.000816,115
p.R273C,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.679,0.18,0.301,0.118,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,116
p.R273C,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.675,0.18,0.301,0.118,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,117
p.R273C,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.7,0.18,0.329,0.118,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,118
p.R273C,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.631,0.18,0.235,0.118,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,119
p.R273C,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.686,0.18,0.309,0.118,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,120
p.R273C,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.579,0.4,0.424,0.118,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,121
p.R273C,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.673,0.18,0.309,0.117,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,122
p.R273C,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.683,0.18,0.317,0.117,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,123
p.R273C,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.624,0.18,0.236,0.117,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,124
p.R273C,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.672,0.18,0.303,0.117,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,125
p.R273C,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.666,0.18,0.309,0.116,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,126
p.R273C,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.676,0.18,0.322,0.116,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,127
p.R273C,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.609,0.18,0.228,0.116,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,128
p.R273C,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.658,0.18,0.298,0.116,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,129
p.R273C,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.515,0.4,0.356,0.116,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,130
p.R273C,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.681,0.18,0.334,0.116,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,131
p.R273C,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.537,0.4,0.408,0.115,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,132
p.R273C,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.599,0.18,0.233,0.114,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,133
p.R273C,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.665,0.18,0.329,0.114,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,134
p.R273C,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.64,0.18,0.3,0.114,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,443.7,3.58,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,135
p.R273C,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.662,0.18,0.343,0.113,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,136
p.R273C,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.668,0.18,0.35,0.113,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,137
p.R273C,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.657,0.18,0.343,0.112,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,138
p.R273C,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.65,0.18,0.349,0.111,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,139
p.R273C,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.662,0.18,0.364,0.111,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,140
p.R273C,WM-TP53-02730,WM-TP53-02730,screening,-3.39,-3.2,0.063,0.0,0.063,0.259,0.02,0.572,0.18,0.414,0.109,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.003259,141
p.R273C,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.641,0.18,0.373,0.108,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,142
p.R273C,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.601,0.18,0.324,0.107,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,143
p.R273C,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.624,0.18,0.356,0.107,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,144
p.R273C,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.536,0.4,0.506,0.107,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,145
p.R273C,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.632,0.18,0.366,0.107,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,146
p.R273C,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.642,0.18,0.38,0.107,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,429.7,4.91,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,147
p.R273C,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.578,0.18,0.291,0.107,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,404.2,3.44,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,148
p.R273C,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.581,0.18,0.307,0.106,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,149
p.R273C,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.592,0.18,0.317,0.106,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,150
p.R273C,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.629,0.18,0.373,0.106,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,151
p.R273C,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.631,0.18,0.376,0.106,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,152
p.R273C,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.02,0.575,0.18,0.434,0.105,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.003487,153
p.R273C,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.617,0.18,0.374,0.105,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,154
p.R273C,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.506,0.4,0.489,0.104,0.81,"C273,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,developability-risk,No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,155
p.R273C,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.634,0.18,0.418,0.103,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,297.7,1.03,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,156
p.R273C,WM-TP53-02492,WM-TP53-02492,screening,-3.33,-3.2,0.043,0.0,0.043,0.256,0.02,0.546,0.18,0.419,0.102,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.003607,157
p.R273C,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.6,0.18,0.402,0.101,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,158
p.R273C,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.603,0.18,0.403,0.101,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,159
p.R273C,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.601,0.18,0.428,0.099,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,160
p.R273C,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.587,0.18,0.418,0.098,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,161
p.R273C,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.572,0.18,0.409,0.097,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,162
p.R273C,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.608,0.18,0.459,0.097,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,163
p.R273C,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.568,0.18,0.418,0.096,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,164
p.R273C,WM-TP53-05093,WM-TP53-05093,screening,-3.3,-3.2,0.033,0.0,0.033,0.255,0.02,0.523,0.18,0.447,0.095,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.003794,165
p.R273C,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.555,0.18,0.411,0.095,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,166
p.R273C,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.558,0.18,0.411,0.095,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,167
p.R273C,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.572,0.18,0.436,0.095,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,168
p.R273C,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.597,0.18,0.464,0.095,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,169
p.R273C,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.556,0.18,0.437,0.093,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,170
p.R273C,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.544,0.18,0.411,0.093,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,171
p.R273C,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.59,0.18,0.486,0.093,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,172
p.R273C,WM-TP53-03988,WM-TP53-03988,screening,-3.22,-3.2,0.007,0.0,0.007,0.251,0.02,0.555,0.18,0.463,0.092,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004343,173
p.R273C,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.559,0.18,0.448,0.092,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,174
p.R273C,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.539,0.18,0.416,0.092,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,175
p.R273C,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.554,0.18,0.444,0.092,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,176
p.R273C,WM-TP53-06895,WM-TP53-06895,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.02,0.521,0.18,0.435,0.091,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,230.4,0.81,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004199,177
p.R273C,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.581,0.18,0.488,0.091,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,178
p.R273C,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.527,0.18,0.418,0.091,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,179
p.R273C,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.554,0.18,0.458,0.091,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,180
p.R273C,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.539,0.18,0.46,0.089,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,181
p.R273C,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.532,0.18,0.447,0.089,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,182
p.R273C,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.506,0.18,0.42,0.088,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,183
p.R273C,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.647,0.18,0.634,0.088,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,184
p.R273C,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.65,0.18,0.634,0.088,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,185
p.R273C,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.534,0.18,0.459,0.088,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,552.3,4.52,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,186
p.R273C,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.528,0.18,0.455,0.088,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,404.0,1.98,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,187
p.R273C,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.646,0.18,0.647,0.087,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,188
p.R273C,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.557,0.18,0.521,0.086,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,189
p.R273C,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.53,0.18,0.474,0.086,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,190
p.R273C,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.513,0.18,0.451,0.086,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,191
p.R273C,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.528,0.18,0.492,0.085,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,192
p.R273C,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.525,0.18,0.49,0.085,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,193
p.R273C,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.553,0.18,0.524,0.085,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,194
p.R273C,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.467,0.18,0.409,0.084,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Specialized DNA-contact route,DNA-contact,Watch,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,195
p.R273C,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.522,0.18,0.496,0.084,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,196
p.R273C,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.503,0.18,0.48,0.083,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,197
p.R273C,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.507,0.18,0.483,0.083,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,198
p.R273C,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.61,0.18,0.641,0.083,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,437.1,4.4,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,199
p.R273C,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.533,0.18,0.53,0.082,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,200
p.R273C,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.482,0.18,0.469,0.081,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,201
p.R273C,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.504,0.18,0.504,0.081,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,202
p.R273C,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.509,0.18,0.516,0.081,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,203
p.R273C,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.517,0.18,0.529,0.081,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,204
p.R273C,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.494,0.18,0.489,0.081,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,205
p.R273C,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.502,0.18,0.496,0.081,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,404.0,2.73,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,206
p.R273C,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.508,0.18,0.538,0.079,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,207
p.R273C,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.508,0.18,0.543,0.078,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,208
p.R273C,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.461,0.18,0.52,0.075,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,209
p.R273C,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.474,0.18,0.544,0.074,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,210
p.R273C,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.484,0.18,0.557,0.074,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,211
p.R273C,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.479,0.18,0.574,0.072,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,212
p.R273C,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.469,0.18,0.58,0.071,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,213
p.R273C,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.447,0.18,0.541,0.071,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,214
p.R273C,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.453,0.18,0.58,0.069,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,215
p.R273C,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.437,0.18,0.57,0.068,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,216
p.R273C,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.537,0.18,0.736,0.066,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,217
p.R273C,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.528,0.18,0.739,0.065,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,218
p.R273C,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.538,0.18,0.758,0.065,0.766,"C273,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Specialized DNA-contact route,DNA-contact,Severe liability,In-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,219
p.R273C,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.02,0.404,0.18,0.779,0.047,0.666,"C273,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Specialized DNA-contact route,DNA-contact,Severe liability,Out-of-domain,DNA-contact defect; small-molecule cavity rescue is unlikely — consider contact restoration or downstream pathway,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not assume a rescue cavity; consider DNA-binding restoration or synthetic-lethal assays,0.004492,220
p.R282W,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.89,"C282,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.R282W,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.89,"C282,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.R282W,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.R282W,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.R282W,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.R282W,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.R282W,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.R282W,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.R282W,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.R282W,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.906,"C282,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.R282W,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.R282W,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.R282W,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.R282W,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.R282W,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.R282W,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.R282W,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.R282W,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.R282W,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.R282W,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.R282W,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.R282W,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.R282W,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.R282W,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.R282W,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.89,"C282,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.R282W,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.R282W,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.R282W,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.R282W,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.R282W,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.R282W,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.R282W,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.R282W,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.R282W,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.R282W,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.R282W,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.R282W,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.R282W,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.R282W,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.R282W,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.R282W,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.R282W,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.R282W,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.R282W,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.R282W,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.R282W,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.R282W,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.R282W,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.R282W,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.R282W,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.R282W,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.R282W,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.R282W,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.R282W,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.R282W,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.R282W,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.R282W,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.R282W,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.R282W,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.R282W,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.R282W,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,377.3,1.73,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.R282W,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.R282W,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.R282W,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.R282W,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.R282W,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.R282W,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.R282W,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.R282W,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.R282W,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.R282W,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.R282W,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.R282W,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.R282W,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.R282W,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.R282W,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.R282W,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.R282W,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.R282W,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.R282W,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.R282W,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.R282W,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.R282W,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.R282W,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.R282W,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.R282W,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.R282W,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.R282W,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,389.6,2.36,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.R282W,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.R282W,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.R282W,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.854,"C282,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.R282W,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.R282W,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.R282W,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.R282W,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Specialized DNA-contact route,Structural / cavity or core,Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.R282W,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.R282W,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.R282W,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.R282W,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.R282W,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.R282W,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.R282W,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.R282W,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.R282W,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.R282W,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.R282W,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.R282W,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.R282W,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.R282W,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.R282W,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.R282W,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,429.0,3.18,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.R282W,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.R282W,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.R282W,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.R282W,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.R282W,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.R282W,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.R282W,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.R282W,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.R282W,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.R282W,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.R282W,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.R282W,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.R282W,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.R282W,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.R282W,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.R282W,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.R282W,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.R282W,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.R282W,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.R282W,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.R282W,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.R282W,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.R282W,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.R282W,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.R282W,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.R282W,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,443.7,3.58,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.R282W,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.R282W,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.R282W,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.R282W,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.R282W,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.R282W,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.R282W,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.R282W,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.R282W,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.R282W,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,429.7,4.91,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.R282W,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,404.2,3.44,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.R282W,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.R282W,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.R282W,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.R282W,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.R282W,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.R282W,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.R282W,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.81,"C282,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.R282W,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.R282W,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,297.7,1.03,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.R282W,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.R282W,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.R282W,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.R282W,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.R282W,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.R282W,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.R282W,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.R282W,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.R282W,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.R282W,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.R282W,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.R282W,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.R282W,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.R282W,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.R282W,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.R282W,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.R282W,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.R282W,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.R282W,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.R282W,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.R282W,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.R282W,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.R282W,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.R282W,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.R282W,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.R282W,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.R282W,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.R282W,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,552.3,4.52,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.R282W,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.R282W,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,404.0,1.98,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.R282W,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.R282W,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.R282W,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.R282W,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.R282W,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.R282W,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.R282W,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Specialized DNA-contact route,Structural / cavity or core,Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.R282W,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.R282W,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.R282W,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.R282W,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.R282W,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.R282W,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,437.1,4.4,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.R282W,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.R282W,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.R282W,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.R282W,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,404.0,2.73,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.R282W,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.R282W,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.R282W,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.R282W,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.R282W,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.R282W,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.R282W,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.R282W,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.R282W,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.R282W,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.R282W,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.R282W,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.R282W,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.R282W,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.R282W,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.766,"C282,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Specialized DNA-contact route,Structural / cavity or core,Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.R282W,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.666,"C282,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Specialized DNA-contact route,Structural / cavity or core,Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.V172F,CTRL-001,PK083,preclinical,-5.01,-3.31,0.567,0.126,0.567,0.404,0.365,0.645,0.8,0.363,0.374,0.86,"C172,R158,M160,Y163",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000211,1
p.V172F,WM-TP53-00860,WM-TP53-00860,preclinical,-4.64,-3.26,0.46,0.08,0.46,0.363,0.237,0.719,0.4,0.292,0.295,0.78,"C172,R158,M160,Y163",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000395,2
p.V172F,WM-TP53-07201,WM-TP53-07201,screening,-4.81,-3.73,0.36,0.101,0.36,0.36,0.217,0.758,0.18,0.234,0.265,0.736,"C172,R158,M160,Y163",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000296,3
p.V172F,WM-TP53-00146,WM-TP53-00146,screening,-4.6,-3.39,0.403,0.075,0.403,0.352,0.219,0.769,0.18,0.273,0.264,0.736,"C172,R158,M160,Y163",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000422,4
p.V172F,WM-TP53-05841,WM-TP53-05841,clinical,-4.05,-3.2,0.283,0.006,0.283,0.296,0.157,0.731,0.62,0.249,0.251,0.824,"C172,R158,M160,Y163",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001069,5
p.V172F,WM-TP53-02322,WM-TP53-02322,preclinical,-4.42,-3.78,0.213,0.052,0.213,0.311,0.156,0.812,0.4,0.176,0.245,0.78,"C172,R158,M160,Y163",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000572,6
p.V172F,CTRL-003,PK11000,preclinical,-3.31,-3.2,0.037,0.0,0.037,0.256,0.165,0.854,0.8,0.171,0.24,0.86,"C172,R158,M160,Y163",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00373,7
p.V172F,WM-TP53-01421,WM-TP53-01421,screening,-4.51,-3.2,0.437,0.064,0.437,0.351,0.224,0.561,0.18,0.321,0.24,0.736,"C172,R158,M160,Y163",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000491,8
p.V172F,WM-TP53-05637,WM-TP53-05637,screening,-4.33,-3.22,0.37,0.041,0.37,0.328,0.195,0.716,0.18,0.26,0.239,0.736,"C172,R158,M160,Y163",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000666,9
p.V172F,WM-TP53-01438,WM-TP53-01438,screening,-4.47,-3.6,0.29,0.059,0.29,0.326,0.18,0.779,0.18,0.212,0.237,0.736,"C172,R158,M160,Y163",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000526,10
p.V172F,WM-TP53-03410,WM-TP53-03410,screening,-4.05,-3.2,0.283,0.006,0.283,0.296,0.157,0.79,0.18,0.229,0.216,0.736,"C172,R158,M160,Y163",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001069,11
p.V172F,WM-TP53-05280,WM-TP53-05280,screening,-4.39,-3.76,0.21,0.049,0.21,0.308,0.154,0.699,0.18,0.188,0.206,0.736,"C172,R158,M160,Y163",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000602,12
p.V172F,WM-TP53-00707,WM-TP53-00707,screening,-3.86,-3.2,0.22,0.0,0.22,0.283,0.137,0.792,0.18,0.24,0.198,0.736,"C172,R158,M160,Y163",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001473,13
p.V172F,WM-TP53-02764,WM-TP53-02764,screening,-3.83,-3.2,0.21,0.0,0.21,0.281,0.134,0.781,0.18,0.191,0.198,0.736,"C172,R158,M160,Y163",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00155,14
p.V172F,WM-TP53-01795,WM-TP53-01795,screening,-4.08,-3.25,0.277,0.01,0.277,0.297,0.157,0.61,0.18,0.217,0.195,0.736,"C172,R158,M160,Y163",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001016,15
p.V172F,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.876,"C172,R158,M160,Y163",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.V172F,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.824,"C172,R158,M160,Y163",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,17
p.V172F,WM-TP53-06810,WM-TP53-06810,clinical,-3.92,-3.2,0.24,0.0,0.24,0.286,0.142,0.508,0.62,0.543,0.188,0.824,"C172,R158,M160,Y163",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001331,18
p.V172F,WM-TP53-07949,WM-TP53-07949,approved,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.651,0.72,0.244,0.188,0.844,"C172,R158,M160,Y163",Pass,False,True,255.6,2.69,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,19
p.V172F,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.824,"C172,R158,M160,Y163",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,20
p.V172F,WM-TP53-04600,WM-TP53-04600,screening,-3.67,-3.2,0.157,0.0,0.157,0.274,0.119,0.791,0.18,0.204,0.185,0.736,"C172,R158,M160,Y163",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002031,21
p.V172F,WM-TP53-03546,WM-TP53-03546,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.757,0.18,0.272,0.184,0.736,"C172,R158,M160,Y163",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,22
p.V172F,WM-TP53-06623,WM-TP53-06623,screening,-3.78,-3.2,0.193,0.0,0.193,0.279,0.129,0.727,0.18,0.242,0.183,0.736,"C172,R158,M160,Y163",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001686,23
p.V172F,WM-TP53-04481,WM-TP53-04481,preclinical,-3.58,-3.2,0.127,0.0,0.127,0.269,0.111,0.711,0.4,0.321,0.181,0.78,"C172,R158,M160,Y163",Pass,False,True,275.4,3.9,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002364,24
p.V172F,WM-TP53-05586,WM-TP53-05586,screening,-3.92,-3.42,0.167,0.0,0.167,0.275,0.122,0.688,0.18,0.172,0.178,0.736,"C172,R158,M160,Y163",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001331,25
p.V172F,WM-TP53-06079,WM-TP53-06079,screening,-3.64,-3.2,0.147,0.0,0.147,0.272,0.116,0.778,0.18,0.257,0.177,0.736,"C172,R158,M160,Y163",Pass,False,True,259.7,2.91,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002136,26
p.V172F,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.824,"C172,R158,M160,Y163",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.V172F,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.824,"C172,R158,M160,Y163",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.V172F,WM-TP53-01217,WM-TP53-01217,screening,-4.54,-3.83,0.237,0.068,0.237,0.323,0.169,0.509,0.18,0.491,0.173,0.736,"C172,R158,M160,Y163",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000467,29
p.V172F,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.824,"C172,R158,M160,Y163",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.V172F,WM-TP53-00367,WM-TP53-00367,screening,-3.73,-3.2,0.177,0.0,0.177,0.277,0.125,0.638,0.18,0.228,0.17,0.736,"C172,R158,M160,Y163",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001835,31
p.V172F,WM-TP53-02798,WM-TP53-02798,screening,-3.52,-3.2,0.107,0.0,0.107,0.266,0.105,0.767,0.18,0.225,0.169,0.736,"C172,R158,M160,Y163",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002616,32
p.V172F,WM-TP53-06555,WM-TP53-06555,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.719,0.18,0.329,0.166,0.736,"C172,R158,M160,Y163",Pass,False,True,265.4,4.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,33
p.V172F,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.78,"C172,R158,M160,Y163",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.V172F,WM-TP53-02526,WM-TP53-02526,screening,-4.46,-3.8,0.22,0.057,0.22,0.315,0.16,0.505,0.18,0.495,0.164,0.736,"C172,R158,M160,Y163",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000535,35
p.V172F,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.86,"C172,R158,M160,Y163",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,36
p.V172F,WM-TP53-05365,WM-TP53-05365,screening,-3.69,-3.2,0.163,0.0,0.163,0.274,0.121,0.694,0.18,0.366,0.162,0.736,"C172,R158,M160,Y163",Pass,False,True,269.4,3.91,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001963,37
p.V172F,WM-TP53-04056,WM-TP53-04056,screening,-3.37,-3.2,0.057,0.0,0.057,0.259,0.091,0.798,0.18,0.198,0.162,0.736,"C172,R158,M160,Y163",Pass,False,True,244.9,1.84,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003371,38
p.V172F,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.824,"C172,R158,M160,Y163",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,39
p.V172F,WM-TP53-06487,WM-TP53-06487,screening,-3.76,-3.2,0.187,0.0,0.187,0.278,0.127,0.637,0.18,0.382,0.16,0.736,"C172,R158,M160,Y163",Pass,False,True,302.0,4.96,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001744,40
p.V172F,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.78,"C172,R158,M160,Y163",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.V172F,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.78,"C172,R158,M160,Y163",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.V172F,WM-TP53-05246,WM-TP53-05246,preclinical,-3.74,-3.22,0.173,0.0,0.173,0.276,0.123,0.507,0.4,0.436,0.158,0.78,"C172,R158,M160,Y163",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,43
p.V172F,WM-TP53-04991,WM-TP53-04991,screening,-3.5,-3.2,0.1,0.0,0.1,0.265,0.103,0.68,0.18,0.202,0.158,0.736,"C172,R158,M160,Y163",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002706,44
p.V172F,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.78,"C172,R158,M160,Y163",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.V172F,WM-TP53-08000,WM-TP53-08000,screening,-3.5,-3.2,0.1,0.0,0.1,0.265,0.103,0.688,0.18,0.224,0.157,0.736,"C172,R158,M160,Y163",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002706,46
p.V172F,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.78,"C172,R158,M160,Y163",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.V172F,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.78,"C172,R158,M160,Y163",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.V172F,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.78,"C172,R158,M160,Y163",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,49
p.V172F,WM-TP53-06028,WM-TP53-06028,screening,-3.69,-3.2,0.163,0.0,0.163,0.274,0.121,0.644,0.18,0.374,0.155,0.736,"C172,R158,M160,Y163",Pass,False,True,292.0,4.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001963,50
p.V172F,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.736,"C172,R158,M160,Y163",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.V172F,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.824,"C172,R158,M160,Y163",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.V172F,WM-TP53-05331,WM-TP53-05331,screening,-3.45,-3.2,0.083,0.0,0.083,0.262,0.098,0.688,0.18,0.222,0.153,0.736,"C172,R158,M160,Y163",Pass,False,True,246.1,2.31,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002945,53
p.V172F,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.824,"C172,R158,M160,Y163",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.V172F,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.736,"C172,R158,M160,Y163",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.V172F,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.736,"C172,R158,M160,Y163",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.V172F,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.736,"C172,R158,M160,Y163",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.V172F,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.78,"C172,R158,M160,Y163",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,58
p.V172F,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.736,"C172,R158,M160,Y163",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.V172F,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.78,"C172,R158,M160,Y163",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.V172F,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.736,"C172,R158,M160,Y163",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.V172F,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.824,"C172,R158,M160,Y163",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,62
p.V172F,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.736,"C172,R158,M160,Y163",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.V172F,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.78,"C172,R158,M160,Y163",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.V172F,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.736,"C172,R158,M160,Y163",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.V172F,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.736,"C172,R158,M160,Y163",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.V172F,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.78,"C172,R158,M160,Y163",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,67
p.V172F,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.736,"C172,R158,M160,Y163",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.V172F,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.78,"C172,R158,M160,Y163",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.V172F,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.736,"C172,R158,M160,Y163",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.V172F,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.824,"C172,R158,M160,Y163",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.V172F,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.736,"C172,R158,M160,Y163",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.V172F,WM-TP53-01625,WM-TP53-01625,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.084,0.694,0.18,0.212,0.142,0.736,"C172,R158,M160,Y163",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,73
p.V172F,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.824,"C172,R158,M160,Y163",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,74
p.V172F,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.736,"C172,R158,M160,Y163",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.V172F,WM-TP53-05705,WM-TP53-05705,screening,-3.76,-3.31,0.15,0.0,0.15,0.273,0.117,0.601,0.18,0.452,0.141,0.736,"C172,R158,M160,Y163",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001744,76
p.V172F,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.736,"C172,R158,M160,Y163",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.V172F,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.736,"C172,R158,M160,Y163",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.V172F,WM-TP53-06402,WM-TP53-06402,screening,-3.7,-3.32,0.127,0.0,0.127,0.269,0.111,0.615,0.18,0.418,0.14,0.736,"C172,R158,M160,Y163",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,79
p.V172F,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.736,"C172,R158,M160,Y163",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.V172F,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.736,"C172,R158,M160,Y163",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.V172F,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.736,"C172,R158,M160,Y163",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.V172F,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.78,"C172,R158,M160,Y163",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.V172F,WM-TP53-07048,WM-TP53-07048,screening,-3.62,-3.2,0.14,0.0,0.14,0.271,0.114,0.592,0.18,0.433,0.139,0.736,"C172,R158,M160,Y163",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00221,84
p.V172F,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.78,"C172,R158,M160,Y163",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.V172F,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.736,"C172,R158,M160,Y163",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.V172F,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.736,"C172,R158,M160,Y163",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.V172F,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.736,"C172,R158,M160,Y163",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.V172F,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.736,"C172,R158,M160,Y163",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,89
p.V172F,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.736,"C172,R158,M160,Y163",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.V172F,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.736,"C172,R158,M160,Y163",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.V172F,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.736,"C172,R158,M160,Y163",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.V172F,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.736,"C172,R158,M160,Y163",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.V172F,WM-TP53-00214,WM-TP53-00214,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.742,0.18,0.267,0.137,0.736,"C172,R158,M160,Y163",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,94
p.V172F,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.736,"C172,R158,M160,Y163",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.V172F,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.736,"C172,R158,M160,Y163",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.V172F,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.736,"C172,R158,M160,Y163",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.V172F,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.736,"C172,R158,M160,Y163",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.V172F,WM-TP53-05926,WM-TP53-05926,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.66,0.18,0.224,0.136,0.736,"C172,R158,M160,Y163",Pass,False,True,246.6,2.35,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,99
p.V172F,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.824,"C172,R158,M160,Y163",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.V172F,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.736,"C172,R158,M160,Y163",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,Loop (L1/L2/L3),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,101
p.V172F,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.736,"C172,R158,M160,Y163",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.V172F,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.736,"C172,R158,M160,Y163",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.V172F,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.736,"C172,R158,M160,Y163",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.V172F,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.736,"C172,R158,M160,Y163",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.V172F,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.736,"C172,R158,M160,Y163",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.V172F,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.736,"C172,R158,M160,Y163",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.V172F,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.736,"C172,R158,M160,Y163",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.V172F,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.736,"C172,R158,M160,Y163",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.V172F,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.736,"C172,R158,M160,Y163",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.V172F,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.78,"C172,R158,M160,Y163",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.V172F,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.736,"C172,R158,M160,Y163",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.V172F,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.736,"C172,R158,M160,Y163",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.V172F,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.736,"C172,R158,M160,Y163",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.V172F,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.736,"C172,R158,M160,Y163",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.V172F,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.736,"C172,R158,M160,Y163",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.V172F,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.736,"C172,R158,M160,Y163",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.V172F,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.736,"C172,R158,M160,Y163",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.V172F,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.736,"C172,R158,M160,Y163",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.V172F,WM-TP53-03988,WM-TP53-03988,screening,-3.55,-3.2,0.117,0.0,0.117,0.268,0.108,0.555,0.18,0.463,0.127,0.736,"C172,R158,M160,Y163",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002487,120
p.V172F,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.736,"C172,R158,M160,Y163",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.V172F,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.736,"C172,R158,M160,Y163",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.V172F,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.736,"C172,R158,M160,Y163",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.V172F,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.736,"C172,R158,M160,Y163",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.V172F,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.736,"C172,R158,M160,Y163",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.V172F,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.736,"C172,R158,M160,Y163",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.V172F,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.78,"C172,R158,M160,Y163",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.V172F,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.736,"C172,R158,M160,Y163",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.V172F,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.736,"C172,R158,M160,Y163",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.V172F,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.736,"C172,R158,M160,Y163",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.V172F,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.736,"C172,R158,M160,Y163",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.V172F,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.736,"C172,R158,M160,Y163",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.V172F,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.736,"C172,R158,M160,Y163",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.V172F,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.736,"C172,R158,M160,Y163",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.V172F,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.736,"C172,R158,M160,Y163",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.V172F,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.736,"C172,R158,M160,Y163",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.V172F,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.78,"C172,R158,M160,Y163",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.V172F,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.736,"C172,R158,M160,Y163",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.V172F,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.736,"C172,R158,M160,Y163",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.V172F,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.78,"C172,R158,M160,Y163",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.V172F,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.736,"C172,R158,M160,Y163",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.V172F,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.736,"C172,R158,M160,Y163",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.V172F,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.736,"C172,R158,M160,Y163",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,143
p.V172F,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.736,"C172,R158,M160,Y163",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.V172F,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.736,"C172,R158,M160,Y163",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.V172F,WM-TP53-05739,WM-TP53-05739,screening,-3.4,-3.2,0.067,0.0,0.067,0.26,0.094,0.575,0.18,0.434,0.119,0.736,"C172,R158,M160,Y163",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003204,146
p.V172F,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.736,"C172,R158,M160,Y163",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.V172F,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.736,"C172,R158,M160,Y163",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.V172F,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.736,"C172,R158,M160,Y163",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.V172F,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.736,"C172,R158,M160,Y163",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.V172F,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.736,"C172,R158,M160,Y163",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.V172F,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.736,"C172,R158,M160,Y163",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.V172F,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.736,"C172,R158,M160,Y163",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.V172F,WM-TP53-05093,WM-TP53-05093,screening,-3.43,-3.2,0.077,0.0,0.077,0.262,0.097,0.523,0.18,0.447,0.114,0.736,"C172,R158,M160,Y163",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,154
p.V172F,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.736,"C172,R158,M160,Y163",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.V172F,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.736,"C172,R158,M160,Y163",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,156
p.V172F,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.736,"C172,R158,M160,Y163",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.V172F,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.78,"C172,R158,M160,Y163",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,158
p.V172F,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.736,"C172,R158,M160,Y163",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.V172F,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.736,"C172,R158,M160,Y163",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.V172F,WM-TP53-01472,WM-TP53-01472,screening,-3.45,-3.2,0.083,0.0,0.083,0.262,0.098,0.522,0.18,0.496,0.112,0.736,"C172,R158,M160,Y163",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002945,161
p.V172F,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.78,"C172,R158,M160,Y163",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.V172F,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.736,"C172,R158,M160,Y163",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,163
p.V172F,WM-TP53-06589,WM-TP53-06589,screening,-3.38,-3.2,0.06,0.0,0.06,0.259,0.092,0.547,0.18,0.506,0.108,0.736,"C172,R158,M160,Y163",Pass,False,True,256.5,2.89,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003314,164
p.V172F,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.736,"C172,R158,M160,Y163",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.V172F,WM-TP53-05671,WM-TP53-05671,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.084,0.577,0.18,0.482,0.107,0.736,"C172,R158,M160,Y163",Pass,False,True,248.0,2.49,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,166
p.V172F,WM-TP53-03087,WM-TP53-03087,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.59,0.18,0.486,0.107,0.736,"C172,R158,M160,Y163",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,167
p.V172F,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.736,"C172,R158,M160,Y163",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.V172F,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.736,"C172,R158,M160,Y163",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.V172F,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.736,"C172,R158,M160,Y163",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.V172F,WM-TP53-00299,WM-TP53-00299,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.081,0.581,0.18,0.488,0.104,0.736,"C172,R158,M160,Y163",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,171
p.V172F,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.736,"C172,R158,M160,Y163",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.V172F,WM-TP53-02730,WM-TP53-02730,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.414,0.104,0.736,"C172,R158,M160,Y163",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.V172F,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.736,"C172,R158,M160,Y163",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.V172F,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.736,"C172,R158,M160,Y163",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.V172F,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.736,"C172,R158,M160,Y163",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.V172F,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.736,"C172,R158,M160,Y163",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.V172F,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.736,"C172,R158,M160,Y163",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.V172F,WM-TP53-02492,WM-TP53-02492,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.18,0.419,0.101,0.736,"C172,R158,M160,Y163",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.V172F,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.736,"C172,R158,M160,Y163",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.V172F,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.736,"C172,R158,M160,Y163",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.V172F,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.736,"C172,R158,M160,Y163",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.V172F,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.736,"C172,R158,M160,Y163",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.V172F,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.736,"C172,R158,M160,Y163",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.V172F,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.736,"C172,R158,M160,Y163",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.V172F,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.736,"C172,R158,M160,Y163",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.V172F,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.736,"C172,R158,M160,Y163",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.V172F,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.736,"C172,R158,M160,Y163",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.V172F,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.736,"C172,R158,M160,Y163",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.V172F,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.736,"C172,R158,M160,Y163",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.V172F,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.736,"C172,R158,M160,Y163",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.V172F,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.736,"C172,R158,M160,Y163",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.V172F,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.736,"C172,R158,M160,Y163",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.V172F,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.736,"C172,R158,M160,Y163",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.V172F,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.736,"C172,R158,M160,Y163",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.V172F,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.736,"C172,R158,M160,Y163",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.V172F,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.736,"C172,R158,M160,Y163",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,Loop (L1/L2/L3),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.V172F,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.736,"C172,R158,M160,Y163",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.V172F,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.736,"C172,R158,M160,Y163",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.V172F,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.736,"C172,R158,M160,Y163",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.V172F,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.736,"C172,R158,M160,Y163",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.V172F,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.736,"C172,R158,M160,Y163",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.V172F,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.736,"C172,R158,M160,Y163",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.V172F,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.736,"C172,R158,M160,Y163",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.V172F,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.736,"C172,R158,M160,Y163",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.V172F,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.736,"C172,R158,M160,Y163",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.V172F,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.736,"C172,R158,M160,Y163",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.V172F,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.736,"C172,R158,M160,Y163",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.V172F,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.736,"C172,R158,M160,Y163",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.V172F,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.736,"C172,R158,M160,Y163",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.V172F,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.736,"C172,R158,M160,Y163",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.V172F,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.736,"C172,R158,M160,Y163",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.V172F,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.736,"C172,R158,M160,Y163",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.V172F,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.736,"C172,R158,M160,Y163",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.V172F,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.736,"C172,R158,M160,Y163",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.V172F,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.736,"C172,R158,M160,Y163",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.V172F,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.736,"C172,R158,M160,Y163",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.V172F,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.736,"C172,R158,M160,Y163",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.V172F,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.736,"C172,R158,M160,Y163",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.V172F,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.636,"C172,R158,M160,Y163",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,Loop (L1/L2/L3),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.V274F,CTRL-001,PK083,preclinical,-4.32,-3.31,0.337,0.04,0.337,0.323,0.266,0.645,0.8,0.363,0.287,0.86,"C274,R158,M160,Y163,R273,R249",Pass,True,True,238.3,3.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,1
p.V274F,CTRL-003,PK11000,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.854,0.8,0.171,0.231,0.86,"C274,R158,M160,Y163,R273,R249",Pass,True,True,236.6,1.15,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,known-ligand-control,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,2
p.V274F,WM-TP53-00860,WM-TP53-00860,preclinical,-4.12,-3.26,0.287,0.015,0.287,0.301,0.161,0.719,0.4,0.292,0.229,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,224.4,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,3
p.V274F,WM-TP53-02322,WM-TP53-02322,preclinical,-4.29,-3.78,0.17,0.036,0.17,0.295,0.137,0.812,0.4,0.176,0.228,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.28,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000713,4
p.V274F,WM-TP53-05841,WM-TP53-05841,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.122,0.731,0.62,0.249,0.221,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,245.7,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,5
p.V274F,WM-TP53-07201,WM-TP53-07201,screening,-4.45,-3.73,0.24,0.056,0.24,0.317,0.165,0.758,0.18,0.234,0.22,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,219.3,2.54,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,6
p.V274F,WM-TP53-00146,WM-TP53-00146,screening,-4.17,-3.39,0.26,0.021,0.26,0.301,0.157,0.769,0.18,0.273,0.21,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,204.8,3.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,7
p.V274F,WM-TP53-01438,WM-TP53-01438,screening,-4.22,-3.6,0.207,0.027,0.207,0.296,0.144,0.779,0.18,0.212,0.205,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,198.0,2.13,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000802,8
p.V274F,WM-TP53-05637,WM-TP53-05637,screening,-3.95,-3.22,0.243,0.0,0.243,0.286,0.143,0.716,0.18,0.26,0.193,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,191.7,2.96,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001265,9
p.V274F,CTRL-004,PC14586,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.599,0.88,0.388,0.191,0.876,"C274,R158,M160,Y163,R273,R249",Pass,True,False,548.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,10
p.V274F,WM-TP53-05280,WM-TP53-05280,screening,-4.27,-3.76,0.17,0.034,0.17,0.294,0.136,0.699,0.18,0.188,0.191,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.59,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000737,11
p.V274F,WM-TP53-03410,WM-TP53-03410,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.128,0.79,0.18,0.229,0.191,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,185.6,2.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,12
p.V274F,WM-TP53-00877,WM-TP53-00877,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.807,0.62,0.228,0.191,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,316.9,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,13
p.V274F,WM-TP53-00962,WM-TP53-00962,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.781,0.62,0.256,0.186,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,301.9,2.17,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,repurposing-eligible,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,14
p.V274F,WM-TP53-02764,WM-TP53-02764,screening,-3.66,-3.2,0.153,0.0,0.153,0.273,0.118,0.781,0.18,0.191,0.184,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,221.3,1.67,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002065,15
p.V274F,WM-TP53-02900,WM-TP53-02900,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.62,0.267,0.176,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,377.5,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,16
p.V274F,WM-TP53-01421,WM-TP53-01421,screening,-3.99,-3.2,0.263,0.0,0.263,0.289,0.149,0.561,0.18,0.321,0.174,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,233.3,3.9,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,17
p.V274F,WM-TP53-05586,WM-TP53-05586,screening,-3.87,-3.42,0.15,0.0,0.15,0.273,0.117,0.688,0.18,0.172,0.174,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.18,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,18
p.V274F,WM-TP53-02560,WM-TP53-02560,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.707,0.62,0.288,0.174,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,389.1,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,19
p.V274F,WM-TP53-01795,WM-TP53-01795,screening,-3.85,-3.25,0.2,0.0,0.2,0.28,0.131,0.61,0.18,0.217,0.173,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,233.2,2.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001498,20
p.V274F,WM-TP53-01676,WM-TP53-01676,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.708,0.62,0.333,0.171,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,278.8,3.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,21
p.V274F,WM-TP53-04600,WM-TP53-04600,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.791,0.18,0.204,0.168,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,213.7,1.97,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,22
p.V274F,WM-TP53-06810,WM-TP53-06810,clinical,-3.63,-3.2,0.143,0.0,0.143,0.271,0.115,0.508,0.62,0.543,0.165,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,180.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,23
p.V274F,WM-TP53-03070,WM-TP53-03070,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.77,0.4,0.225,0.165,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,372.7,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,24
p.V274F,CTRL-002,PK7088,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.155,0.609,0.8,0.653,0.163,0.86,"C274,R158,M160,Y163,R273,R249",Pass,True,True,364.2,4.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,25
p.V274F,WM-TP53-00707,WM-TP53-00707,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.095,0.792,0.18,0.24,0.162,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,260.5,2.63,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,26
p.V274F,WM-TP53-01285,WM-TP53-01285,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.62,0.315,0.161,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,False,562.0,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,27
p.V274F,WM-TP53-02934,WM-TP53-02934,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.4,0.267,0.16,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,365.4,3.07,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,28
p.V274F,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.696,0.4,0.189,0.159,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,340.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,29
p.V274F,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.4,0.203,0.158,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,329.1,1.95,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,30
p.V274F,WM-TP53-06623,WM-TP53-06623,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.727,0.18,0.242,0.157,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,244.5,2.67,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,31
p.V274F,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.695,0.4,0.206,0.157,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,328.2,2.01,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,32
p.V274F,WM-TP53-00571,WM-TP53-00571,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.4,0.272,0.157,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,360.3,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,33
p.V274F,WM-TP53-01557,WM-TP53-01557,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.4,0.262,0.157,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,337.0,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,34
p.V274F,WM-TP53-03053,WM-TP53-03053,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.839,0.18,0.178,0.155,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,266.6,1.35,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,35
p.V274F,WM-TP53-05246,WM-TP53-05246,preclinical,-3.68,-3.22,0.153,0.0,0.153,0.273,0.118,0.507,0.4,0.436,0.154,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,36
p.V274F,WM-TP53-02203,WM-TP53-02203,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.627,0.62,0.426,0.154,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,289.5,1.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,37
p.V274F,WM-TP53-01914,WM-TP53-01914,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.565,0.62,0.339,0.153,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,339.0,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,38
p.V274F,WM-TP53-01217,WM-TP53-01217,screening,-4.38,-3.83,0.183,0.047,0.183,0.304,0.146,0.509,0.18,0.491,0.152,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,181.1,1.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000612,39
p.V274F,WM-TP53-01897,WM-TP53-01897,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.821,0.18,0.182,0.152,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,235.9,1.44,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,40
p.V274F,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.171,0.15,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,307.8,1.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,41
p.V274F,WM-TP53-01132,WM-TP53-01132,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.159,0.15,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,332.6,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,42
p.V274F,WM-TP53-02543,WM-TP53-02543,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.693,0.4,0.292,0.15,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,435.5,3.45,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,43
p.V274F,WM-TP53-03546,WM-TP53-03546,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.757,0.18,0.272,0.149,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,242.1,3.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,44
p.V274F,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.804,0.18,0.197,0.149,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,316.8,1.81,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,45
p.V274F,WM-TP53-01540,WM-TP53-01540,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.698,0.4,0.315,0.149,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,320.1,3.08,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,46
p.V274F,WM-TP53-01727,WM-TP53-01727,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.812,0.18,0.209,0.149,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,247.7,2.06,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,47
p.V274F,WM-TP53-03172,WM-TP53-03172,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.797,0.18,0.189,0.149,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,241.8,1.63,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,48
p.V274F,WM-TP53-00367,WM-TP53-00367,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.099,0.638,0.18,0.228,0.148,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,248.0,2.43,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,49
p.V274F,WM-TP53-01455,WM-TP53-01455,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.62,0.419,0.148,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,372.3,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,50
p.V274F,WM-TP53-01982,WM-TP53-01982,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.785,0.18,0.179,0.148,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,226.1,1.39,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,51
p.V274F,WM-TP53-02747,WM-TP53-02747,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.651,0.4,0.256,0.148,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,232.3,2.16,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,52
p.V274F,WM-TP53-02526,WM-TP53-02526,screening,-4.32,-3.8,0.173,0.04,0.173,0.298,0.14,0.505,0.18,0.495,0.146,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,53
p.V274F,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.168,0.146,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,336.2,1.06,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,54
p.V274F,WM-TP53-00435,WM-TP53-00435,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.159,0.146,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,213.0,0.73,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,55
p.V274F,WM-TP53-00996,WM-TP53-00996,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.677,0.4,0.34,0.145,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,451.4,4.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,56
p.V274F,WM-TP53-01761,WM-TP53-01761,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.767,0.18,0.19,0.145,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,320.9,1.66,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,57
p.V274F,WM-TP53-04991,WM-TP53-04991,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.086,0.68,0.18,0.202,0.144,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,231.0,1.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,58
p.V274F,WM-TP53-02101,WM-TP53-02101,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.591,0.4,0.221,0.144,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,470.9,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,59
p.V274F,WM-TP53-02645,WM-TP53-02645,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.774,0.18,0.219,0.144,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,439.1,2.26,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,60
p.V274F,WM-TP53-03240,WM-TP53-03240,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.76,0.18,0.194,0.144,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,377.3,1.73,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,61
p.V274F,WM-TP53-02798,WM-TP53-02798,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.076,0.767,0.18,0.225,0.143,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,243.8,2.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,62
p.V274F,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.62,0.412,0.143,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,314.4,0.85,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,63
p.V274F,WM-TP53-01064,WM-TP53-01064,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.776,0.18,0.234,0.143,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,277.7,1.79,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,64
p.V274F,WM-TP53-01149,WM-TP53-01149,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.546,0.62,0.455,0.142,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,429.4,1.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,65
p.V274F,WM-TP53-02509,WM-TP53-02509,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.188,0.142,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,426.8,1.61,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,66
p.V274F,WM-TP53-06402,WM-TP53-06402,screening,-3.71,-3.32,0.13,0.0,0.13,0.27,0.112,0.615,0.18,0.418,0.141,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,180.0,1.06,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,67
p.V274F,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.178,0.141,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,312.3,1.34,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,68
p.V274F,WM-TP53-01115,WM-TP53-01115,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.75,0.18,0.221,0.141,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,329.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,69
p.V274F,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.17,0.14,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,332.5,1.12,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,70
p.V274F,WM-TP53-01030,WM-TP53-01030,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.743,0.18,0.215,0.14,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,362.5,2.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,71
p.V274F,WM-TP53-01353,WM-TP53-01353,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.775,0.18,0.264,0.14,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,300.0,2.29,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,72
p.V274F,WM-TP53-02271,WM-TP53-02271,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.619,0.4,0.304,0.14,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,491.9,3.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,73
p.V274F,WM-TP53-05705,WM-TP53-05705,screening,-3.74,-3.31,0.143,0.0,0.143,0.271,0.115,0.601,0.18,0.452,0.139,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,206.4,1.19,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,74
p.V274F,WM-TP53-01574,WM-TP53-01574,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.633,0.4,0.339,0.139,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,404.2,4.19,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,75
p.V274F,WM-TP53-02152,WM-TP53-02152,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.754,0.18,0.248,0.139,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,333.8,2.76,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,76
p.V274F,WM-TP53-02169,WM-TP53-02169,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.235,0.139,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,336.7,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,77
p.V274F,WM-TP53-02356,WM-TP53-02356,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.744,0.18,0.232,0.139,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,371.0,2.49,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,78
p.V274F,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.73,0.18,0.221,0.138,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,487.1,2.3,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,79
p.V274F,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.227,0.138,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,332.2,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,80
p.V274F,WM-TP53-01183,WM-TP53-01183,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.735,0.18,0.231,0.138,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,422.0,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,81
p.V274F,WM-TP53-01744,WM-TP53-01744,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.733,0.18,0.231,0.138,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,386.6,2.48,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,82
p.V274F,WM-TP53-01812,WM-TP53-01812,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.746,0.18,0.249,0.138,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,401.6,2.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,83
p.V274F,WM-TP53-01931,WM-TP53-01931,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.731,0.18,0.244,0.137,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,353.4,2.7,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,84
p.V274F,WM-TP53-01999,WM-TP53-01999,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.764,0.18,0.286,0.137,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,327.7,2.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,85
p.V274F,WM-TP53-02713,WM-TP53-02713,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.741,0.18,0.256,0.137,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,371.2,2.89,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,86
p.V274F,WM-TP53-02883,WM-TP53-02883,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.734,0.18,0.244,0.137,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,322.7,1.97,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,87
p.V274F,WM-TP53-03189,WM-TP53-03189,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.718,0.18,0.224,0.137,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,389.6,2.36,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,88
p.V274F,WM-TP53-08000,WM-TP53-08000,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.079,0.688,0.18,0.224,0.136,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,235.4,2.36,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,89
p.V274F,WM-TP53-00214,WM-TP53-00214,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.742,0.18,0.267,0.136,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,243.1,2.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,90
p.V274F,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.62,0.45,0.136,0.824,"C274,R158,M160,Y163,R273,R249",Pass,False,True,396.5,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,91
p.V274F,WM-TP53-02475,WM-TP53-02475,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.756,0.18,0.292,0.136,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,268.7,3.45,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,92
p.V274F,WM-TP53-02594,WM-TP53-02594,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.737,0.18,0.258,0.136,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,431.8,2.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,93
p.V274F,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.196,0.135,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,360.5,1.79,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,94
p.V274F,WM-TP53-01625,WM-TP53-01625,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.694,0.18,0.212,0.135,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,237.4,2.12,Pocket gate → docking if tractable,DBD (other),Acceptable,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,95
p.V274F,WM-TP53-02781,WM-TP53-02781,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.736,0.18,0.272,0.135,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,411.6,2.41,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,96
p.V274F,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.716,0.18,0.249,0.134,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,370.7,2.78,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,97
p.V274F,WM-TP53-01965,WM-TP53-01965,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.727,0.18,0.268,0.134,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,311.1,3.09,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,98
p.V274F,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.275,0.133,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,457.6,3.2,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,99
p.V274F,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.69,0.18,0.223,0.133,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,316.5,2.34,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,100
p.V274F,WM-TP53-07048,WM-TP53-07048,screening,-3.54,-3.2,0.113,0.0,0.113,0.267,0.107,0.592,0.18,0.433,0.132,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,228.8,1.49,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,101
p.V274F,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.712,0.18,0.272,0.132,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,480.9,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,102
p.V274F,WM-TP53-00503,WM-TP53-00503,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.721,0.18,0.288,0.132,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,370.6,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,103
p.V274F,WM-TP53-01523,WM-TP53-01523,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.598,0.4,0.377,0.132,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,364.7,4.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,104
p.V274F,WM-TP53-02611,WM-TP53-02611,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.724,0.18,0.288,0.132,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,347.9,3.4,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,105
p.V274F,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.705,0.18,0.293,0.13,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,455.0,3.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,106
p.V274F,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.709,0.18,0.289,0.13,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,385.0,2.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,107
p.V274F,WM-TP53-02254,WM-TP53-02254,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.71,0.18,0.299,0.13,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,424.3,3.56,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,108
p.V274F,WM-TP53-03104,WM-TP53-03104,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.728,0.18,0.318,0.13,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,385.7,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,109
p.V274F,WM-TP53-02458,WM-TP53-02458,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.671,0.18,0.253,0.129,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,296.0,2.85,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,110
p.V274F,WM-TP53-03342,WM-TP53-03342,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.684,0.18,0.274,0.129,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,429.0,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,111
p.V274F,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.706,0.18,0.31,0.128,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,409.8,2.99,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,112
p.V274F,WM-TP53-02662,WM-TP53-02662,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.279,0.128,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,489.6,3.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,113
p.V274F,WM-TP53-02815,WM-TP53-02815,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.704,0.18,0.32,0.127,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,353.7,3.15,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,114
p.V274F,WM-TP53-03121,WM-TP53-03121,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.687,0.18,0.295,0.127,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,295.8,3.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,115
p.V274F,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.679,0.18,0.301,0.126,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,483.6,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,116
p.V274F,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.307,0.126,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,462.6,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,117
p.V274F,WM-TP53-02050,WM-TP53-02050,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.7,0.18,0.329,0.126,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,364.1,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,118
p.V274F,WM-TP53-02339,WM-TP53-02339,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.686,0.18,0.309,0.126,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,441.4,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,119
p.V274F,WM-TP53-03019,WM-TP53-03019,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.579,0.4,0.424,0.126,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,314.4,1.23,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.V274F,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.673,0.18,0.309,0.125,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,454.6,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,121
p.V274F,WM-TP53-01251,WM-TP53-01251,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.683,0.18,0.317,0.125,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,440.3,3.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,122
p.V274F,WM-TP53-01608,WM-TP53-01608,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.675,0.18,0.301,0.125,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,422.4,3.59,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,123
p.V274F,WM-TP53-02118,WM-TP53-02118,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.672,0.18,0.303,0.125,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,422.5,3.62,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.V274F,WM-TP53-02135,WM-TP53-02135,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.235,0.125,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,371.8,2.55,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.V274F,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.666,0.18,0.309,0.124,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,409.9,3.72,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,126
p.V274F,WM-TP53-00894,WM-TP53-00894,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.676,0.18,0.322,0.124,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,381.2,3.92,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,127
p.V274F,WM-TP53-01506,WM-TP53-01506,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.236,0.124,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,381.7,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,128
p.V274F,WM-TP53-01880,WM-TP53-01880,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.658,0.18,0.298,0.124,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,500.8,1.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,129
p.V274F,WM-TP53-02832,WM-TP53-02832,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.515,0.4,0.356,0.124,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,454.5,4.46,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,130
p.V274F,WM-TP53-01863,WM-TP53-01863,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.609,0.18,0.228,0.123,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,465.3,2.42,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,131
p.V274F,WM-TP53-02951,WM-TP53-02951,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.681,0.18,0.334,0.123,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,327.6,4.1,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,132
p.V274F,WM-TP53-01047,WM-TP53-01047,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.4,0.408,0.122,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,357.5,-0.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,133
p.V274F,WM-TP53-01234,WM-TP53-01234,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.599,0.18,0.233,0.122,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,476.0,2.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,134
p.V274F,WM-TP53-01319,WM-TP53-01319,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.665,0.18,0.329,0.122,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,475.4,4.03,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,135
p.V274F,WM-TP53-02305,WM-TP53-02305,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.668,0.18,0.35,0.121,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,324.3,4.37,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,136
p.V274F,WM-TP53-03274,WM-TP53-03274,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.64,0.18,0.3,0.121,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,443.7,3.58,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,137
p.V274F,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.343,0.12,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,441.0,4.25,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,138
p.V274F,WM-TP53-02084,WM-TP53-02084,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.657,0.18,0.343,0.12,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,385.2,3.51,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.V274F,WM-TP53-02220,WM-TP53-02220,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.349,0.119,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,428.1,4.35,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.V274F,WM-TP53-02373,WM-TP53-02373,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.662,0.18,0.364,0.119,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,445.9,3.88,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,141
p.V274F,WM-TP53-01659,WM-TP53-01659,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.641,0.18,0.373,0.116,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,485.2,4.05,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,142
p.V274F,WM-TP53-05739,WM-TP53-05739,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.575,0.18,0.434,0.115,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,222.6,1.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,143
p.V274F,WM-TP53-00690,WM-TP53-00690,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.324,0.115,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,373.3,3.22,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,144
p.V274F,WM-TP53-01302,WM-TP53-01302,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.624,0.18,0.356,0.115,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,454.4,4.47,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,145
p.V274F,WM-TP53-02441,WM-TP53-02441,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.632,0.18,0.366,0.115,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,499.1,4.64,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.V274F,WM-TP53-03138,WM-TP53-03138,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.642,0.18,0.38,0.115,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,429.7,4.91,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,147
p.V274F,WM-TP53-03257,WM-TP53-03257,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.578,0.18,0.291,0.115,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,404.2,3.44,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,148
p.V274F,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.307,0.114,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,444.5,3.68,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.V274F,WM-TP53-00928,WM-TP53-00928,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.592,0.18,0.317,0.114,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,357.5,3.83,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,150
p.V274F,WM-TP53-01081,WM-TP53-01081,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.629,0.18,0.373,0.114,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,443.5,4.04,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,151
p.V274F,WM-TP53-01591,WM-TP53-01591,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.536,0.4,0.506,0.114,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,299.9,2.9,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,152
p.V274F,WM-TP53-02186,WM-TP53-02186,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.631,0.18,0.376,0.114,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,361.1,4.84,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,153
p.V274F,WM-TP53-01642,WM-TP53-01642,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.617,0.18,0.374,0.113,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,523.3,3.18,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,154
p.V274F,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.4,0.489,0.112,0.78,"C274,R158,M160,Y163,R273,R249",Pass,False,True,302.3,1.88,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.V274F,WM-TP53-02730,WM-TP53-02730,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.083,0.572,0.18,0.414,0.111,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,180.0,0.91,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,156
p.V274F,WM-TP53-03206,WM-TP53-03206,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.634,0.18,0.418,0.111,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,297.7,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,157
p.V274F,WM-TP53-03988,WM-TP53-03988,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.089,0.555,0.18,0.463,0.11,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,256.1,2.15,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,158
p.V274F,WM-TP53-02628,WM-TP53-02628,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.603,0.18,0.403,0.109,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,287.2,0.5,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,159
p.V274F,WM-TP53-01336,WM-TP53-01336,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.6,0.18,0.402,0.108,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,316.7,-0.29,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.V274F,WM-TP53-05093,WM-TP53-05093,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.088,0.523,0.18,0.447,0.107,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,215.5,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,161
p.V274F,WM-TP53-02288,WM-TP53-02288,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.601,0.18,0.428,0.106,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,516.1,3.27,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,162
p.V274F,WM-TP53-02492,WM-TP53-02492,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.08,0.546,0.18,0.419,0.105,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,192.4,1.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,163
p.V274F,WM-TP53-01370,WM-TP53-01370,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.587,0.18,0.418,0.105,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,555.5,3.86,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.V274F,WM-TP53-01948,WM-TP53-01948,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.608,0.18,0.459,0.105,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,279.7,1.33,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.V274F,WM-TP53-01166,WM-TP53-01166,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.409,0.104,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,360.3,0.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,166
p.V274F,WM-TP53-02067,WM-TP53-02067,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.558,0.18,0.411,0.103,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,287.8,0.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,167
p.V274F,WM-TP53-03036,WM-TP53-03036,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.568,0.18,0.418,0.103,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,333.8,1.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.V274F,WM-TP53-03223,WM-TP53-03223,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.597,0.18,0.464,0.103,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,244.4,2.16,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,169
p.V274F,WM-TP53-01778,WM-TP53-01778,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.555,0.18,0.411,0.102,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,415.1,0.79,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.V274F,WM-TP53-02849,WM-TP53-02849,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.572,0.18,0.436,0.102,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,554.9,4.14,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.V274F,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.544,0.18,0.411,0.101,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,251.1,0.8,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.V274F,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.556,0.18,0.437,0.1,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,337.7,0.84,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,173
p.V274F,WM-TP53-01846,WM-TP53-01846,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.559,0.18,0.448,0.1,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,516.8,4.33,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.V274F,WM-TP53-02237,WM-TP53-02237,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.416,0.1,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,378.5,0.99,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,175
p.V274F,WM-TP53-03087,WM-TP53-03087,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.59,0.18,0.486,0.1,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,250.6,2.57,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.V274F,WM-TP53-00299,WM-TP53-00299,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.581,0.18,0.488,0.099,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,236.9,1.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,177
p.V274F,WM-TP53-02917,WM-TP53-02917,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.444,0.099,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,243.0,1.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.V274F,WM-TP53-02577,WM-TP53-02577,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.527,0.18,0.418,0.098,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,377.5,1.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.V274F,WM-TP53-02866,WM-TP53-02866,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.554,0.18,0.458,0.098,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,528.5,4.5,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.V274F,WM-TP53-01387,WM-TP53-01387,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.532,0.18,0.447,0.097,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,469.0,1.82,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,181
p.V274F,WM-TP53-00639,WM-TP53-00639,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.539,0.18,0.46,0.096,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,292.4,2.08,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,182
p.V274F,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.506,0.18,0.42,0.096,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,473.6,1.11,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.V274F,WM-TP53-02696,WM-TP53-02696,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.65,0.18,0.634,0.096,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,468.9,4.27,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,184
p.V274F,WM-TP53-03291,WM-TP53-03291,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.534,0.18,0.459,0.096,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,552.3,4.52,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.V274F,WM-TP53-01200,WM-TP53-01200,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.647,0.18,0.634,0.095,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,404.6,4.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,186
p.V274F,WM-TP53-03308,WM-TP53-03308,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.455,0.095,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,404.0,1.98,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,187
p.V274F,WM-TP53-00231,WM-TP53-00231,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.557,0.18,0.521,0.094,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,294.1,3.13,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.V274F,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.53,0.18,0.474,0.094,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,440.0,2.35,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,189
p.V274F,WM-TP53-00945,WM-TP53-00945,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.513,0.18,0.451,0.094,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,349.3,1.17,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,190
p.V274F,WM-TP53-02968,WM-TP53-02968,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.646,0.18,0.647,0.094,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,357.3,4.55,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.V274F,WM-TP53-01829,WM-TP53-01829,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.553,0.18,0.524,0.093,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,304.8,3.18,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,192
p.V274F,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.492,0.092,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,372.6,2.66,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,193
p.V274F,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.467,0.18,0.409,0.092,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,517.7,3.71,Pocket gate → docking if tractable,DBD (other),Watch,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.V274F,WM-TP53-01710,WM-TP53-01710,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.525,0.18,0.49,0.092,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,360.9,2.63,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,195
p.V274F,WM-TP53-01472,WM-TP53-01472,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.522,0.18,0.496,0.091,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,228.0,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,196
p.V274F,WM-TP53-02424,WM-TP53-02424,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.507,0.18,0.483,0.091,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,428.2,2.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,197
p.V274F,WM-TP53-01404,WM-TP53-01404,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.503,0.18,0.48,0.09,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,471.5,2.46,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,198
p.V274F,WM-TP53-02407,WM-TP53-02407,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.533,0.18,0.53,0.09,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,257.7,2.54,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,199
p.V274F,WM-TP53-03155,WM-TP53-03155,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.61,0.18,0.641,0.09,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,437.1,4.4,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,200
p.V274F,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.482,0.18,0.469,0.089,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,388.2,1.52,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,201
p.V274F,WM-TP53-00979,WM-TP53-00979,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.504,0.18,0.504,0.089,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,481.4,2.86,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,202
p.V274F,WM-TP53-02033,WM-TP53-02033,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.494,0.18,0.489,0.089,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,404.9,2.61,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,203
p.V274F,WM-TP53-03325,WM-TP53-03325,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.502,0.18,0.496,0.089,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,404.0,2.73,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.V274F,WM-TP53-01013,WM-TP53-01013,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.509,0.18,0.516,0.088,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,346.3,3.05,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,205
p.V274F,WM-TP53-01268,WM-TP53-01268,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.517,0.18,0.529,0.088,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,319.4,3.26,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.V274F,WM-TP53-00911,WM-TP53-00911,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.543,0.086,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,352.2,2.74,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,207
p.V274F,WM-TP53-02679,WM-TP53-02679,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.508,0.18,0.538,0.086,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,326.5,3.39,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,208
p.V274F,WM-TP53-01098,WM-TP53-01098,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.474,0.18,0.544,0.082,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,365.9,3.48,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,209
p.V274F,WM-TP53-02016,WM-TP53-02016,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.484,0.18,0.557,0.082,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,365.1,3.68,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.V274F,WM-TP53-03002,WM-TP53-03002,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.461,0.18,0.52,0.082,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,443.2,2.38,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.V274F,WM-TP53-02390,WM-TP53-02390,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.479,0.18,0.574,0.08,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,337.6,3.94,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.V274F,WM-TP53-02985,WM-TP53-02985,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.447,0.18,0.541,0.079,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,398.7,2.7,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.V274F,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.469,0.18,0.58,0.078,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,418.1,3.31,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,214
p.V274F,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.453,0.18,0.58,0.076,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,485.0,4.04,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.V274F,WM-TP53-00010,WM-TP53-00010,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.437,0.18,0.57,0.075,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,True,341.0,3.14,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,216
p.V274F,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.537,0.18,0.736,0.074,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,484.5,5.03,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.V274F,WM-TP53-01489,WM-TP53-01489,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.528,0.18,0.739,0.073,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,463.0,5.1,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.V274F,WM-TP53-01693,WM-TP53-01693,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.538,0.18,0.758,0.072,0.736,"C274,R158,M160,Y163,R273,R249",Pass,False,False,357.0,5.56,Pocket gate → docking if tractable,DBD (other),Severe liability,In-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.V274F,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.075,0.404,0.18,0.779,0.055,0.636,"C274,R158,M160,Y163,R273,R249",Pass,False,False,477.1,6.2,Pocket gate → docking if tractable,DBD (other),Severe liability,Out-of-domain,No strong mutant-created pocket; deprioritize structure-based rescue,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220
p.Y220C,CTRL-004,PC14586,clinical,-11.74,-9.54,0.733,0.968,0.733,0.892,0.98,0.599,0.88,0.388,0.754,0.906,"C220,T150,P151,P222,V147,L145",Pass,True,False,548.6,3.4,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Occupies the mutation-induced hydrophobic cavity and thermodynamically stabilizes the DBD,rescue-score-v1.0,"known-ligand-control,mutant-preferring,strong-mutant-binding,stable-contacts,developability-risk,repurposing-eligible",Go,Biophysical binding (SPR/ITC) + thermal shift → isogenic p53 reporter → viability at exposure-relevant Cmax,0.0,1
p.Y220C,CTRL-003,PK11000,preclinical,-7.44,-5.24,0.733,0.43,0.733,0.596,0.761,0.854,0.8,0.171,0.597,0.89,"C220,T150,P151,P222,V147,L145",Pass,True,True,236.6,1.15,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Occupies the mutation-induced hydrophobic cavity and thermodynamically stabilizes the DBD,rescue-score-v1.0,"known-ligand-control,mutant-preferring",Hold,Orthogonal rescoring / extra MD replica and ADMET triage before wet-lab slot,3e-06,2
p.Y220C,WM-TP53-00861,WM-TP53-00861,clinical,-6.64,-3.81,0.943,0.33,0.943,0.573,0.659,0.63,0.62,0.373,0.534,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,270.6,4.77,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.3e-05,3
p.Y220C,WM-TP53-06382,WM-TP53-06382,clinical,-6.76,-3.77,0.997,0.345,0.997,0.589,0.681,0.613,0.62,0.653,0.528,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,293.4,4.7,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.1e-05,4
p.Y220C,WM-TP53-06036,WM-TP53-06036,clinical,-6.16,-3.2,0.987,0.27,0.987,0.547,0.647,0.643,0.62,0.366,0.525,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,352.2,4.64,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,3e-05,5
p.Y220C,WM-TP53-02839,WM-TP53-02839,screening,-7.38,-4.39,0.997,0.422,0.997,0.632,0.712,0.629,0.18,0.653,0.514,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,250.9,4.68,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4e-06,6
p.Y220C,WM-TP53-01358,WM-TP53-01358,screening,-6.47,-3.41,1.0,0.309,1.0,0.57,0.667,0.706,0.18,0.341,0.508,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,314.0,4.22,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.8e-05,7
p.Y220C,WM-TP53-02821,WM-TP53-02821,approved,-6.24,-3.75,0.83,0.28,0.83,0.528,0.607,0.704,0.72,0.364,0.508,0.874,"C220,T150,P151,P222,V147,L145",Pass,False,True,259.5,3.87,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.6e-05,8
p.Y220C,WM-TP53-07971,WM-TP53-07971,screening,-6.74,-3.2,1.0,0.343,1.0,0.588,0.68,0.621,0.18,0.377,0.507,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,366.3,4.85,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.1e-05,9
p.Y220C,WM-TP53-04777,WM-TP53-04777,screening,-6.66,-3.63,1.0,0.333,1.0,0.583,0.676,0.648,0.18,0.377,0.507,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,289.9,4.86,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.3e-05,10
p.Y220C,WM-TP53-00199,WM-TP53-00199,screening,-6.79,-3.93,0.953,0.349,0.953,0.585,0.67,0.668,0.18,0.354,0.506,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,278.7,4.44,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1e-05,11
p.Y220C,WM-TP53-02386,WM-TP53-02386,screening,-6.61,-3.61,1.0,0.326,1.0,0.579,0.674,0.654,0.18,0.369,0.506,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,289.6,4.7,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.4e-05,12
p.Y220C,WM-TP53-07698,WM-TP53-07698,screening,-6.57,-3.45,1.0,0.321,1.0,0.577,0.672,0.663,0.18,0.358,0.506,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,314.4,4.51,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.5e-05,13
p.Y220C,WM-TP53-01423,WM-TP53-01423,screening,-6.47,-3.22,1.0,0.309,1.0,0.57,0.667,0.686,0.18,0.363,0.504,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,318.8,4.59,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.8e-05,14
p.Y220C,WM-TP53-06487,WM-TP53-06487,screening,-6.62,-3.48,1.0,0.328,1.0,0.58,0.674,0.637,0.18,0.382,0.503,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,302.0,4.96,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.4e-05,15
p.Y220C,WM-TP53-01140,WM-TP53-01140,clinical,-5.94,-3.2,0.913,0.243,0.913,0.52,0.615,0.671,0.62,0.332,0.503,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,319.5,4.08,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.4e-05,16
p.Y220C,WM-TP53-03232,WM-TP53-03232,screening,-7.1,-4.45,0.883,0.387,0.883,0.596,0.666,0.655,0.18,0.344,0.502,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,264.6,4.27,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,6e-06,17
p.Y220C,WM-TP53-07669,WM-TP53-07669,preclinical,-6.07,-3.2,0.957,0.259,0.957,0.536,0.634,0.674,0.4,0.35,0.497,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,350.1,4.36,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.5e-05,18
p.Y220C,WM-TP53-04496,WM-TP53-04496,screening,-6.43,-3.2,1.0,0.304,1.0,0.567,0.665,0.647,0.18,0.38,0.496,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,334.9,4.92,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.9e-05,19
p.Y220C,WM-TP53-00552,WM-TP53-00552,screening,-6.48,-3.57,0.97,0.31,0.97,0.566,0.659,0.661,0.18,0.344,0.495,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,312.8,4.27,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.8e-05,20
p.Y220C,WM-TP53-04049,WM-TP53-04049,screening,-6.33,-3.2,1.0,0.291,1.0,0.56,0.659,0.655,0.18,0.357,0.494,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,333.9,4.49,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.3e-05,21
p.Y220C,WM-TP53-05605,WM-TP53-05605,screening,-6.39,-3.2,1.0,0.299,1.0,0.564,0.662,0.634,0.18,0.368,0.493,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,344.2,4.68,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.1e-05,22
p.Y220C,WM-TP53-06028,WM-TP53-06028,screening,-6.36,-3.22,1.0,0.295,1.0,0.562,0.661,0.644,0.18,0.374,0.493,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,292.0,4.79,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.2e-05,23
p.Y220C,WM-TP53-04216,WM-TP53-04216,screening,-6.23,-3.2,1.0,0.279,1.0,0.553,0.654,0.66,0.18,0.361,0.49,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,304.2,4.56,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.7e-05,24
p.Y220C,WM-TP53-01372,WM-TP53-01372,screening,-6.21,-3.2,1.0,0.276,1.0,0.552,0.653,0.67,0.18,0.356,0.49,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,316.9,4.46,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.8e-05,25
p.Y220C,WM-TP53-00684,WM-TP53-00684,preclinical,-5.98,-3.2,0.927,0.248,0.927,0.525,0.621,0.707,0.4,0.334,0.49,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,301.9,4.1,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.1e-05,26
p.Y220C,WM-TP53-06915,WM-TP53-06915,clinical,-5.87,-3.36,0.837,0.234,0.837,0.504,0.59,0.733,0.62,0.311,0.49,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,272.2,3.75,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.9e-05,27
p.Y220C,WM-TP53-05135,WM-TP53-05135,screening,-6.28,-3.22,1.0,0.285,1.0,0.557,0.657,0.637,0.18,0.364,0.489,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,289.3,4.62,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.5e-05,28
p.Y220C,WM-TP53-00314,WM-TP53-00314,screening,-6.19,-3.2,0.997,0.274,0.997,0.55,0.651,0.674,0.18,0.358,0.489,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,303.9,4.5,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.9e-05,29
p.Y220C,WM-TP53-06457,WM-TP53-06457,clinical,-5.86,-3.2,0.887,0.233,0.887,0.511,0.604,0.647,0.62,0.345,0.489,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,316.9,4.28,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,5e-05,30
p.Y220C,WM-TP53-08262,WM-TP53-08262,screening,-6.89,-3.92,0.99,0.361,0.99,0.597,0.685,0.606,0.18,0.662,0.487,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,283.1,4.91,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,9e-06,31
p.Y220C,WM-TP53-02058,WM-TP53-02058,screening,-6.78,-4.16,0.873,0.348,0.873,0.572,0.647,0.661,0.18,0.326,0.487,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,282.0,3.98,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.1e-05,32
p.Y220C,WM-TP53-00506,WM-TP53-00506,screening,-6.25,-3.2,1.0,0.281,1.0,0.555,0.655,0.633,0.18,0.382,0.486,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,360.4,4.95,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.6e-05,33
p.Y220C,WM-TP53-00481,WM-TP53-00481,clinical,-5.83,-3.2,0.877,0.229,0.877,0.507,0.599,0.658,0.62,0.356,0.486,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,352.7,4.46,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.3e-05,34
p.Y220C,WM-TP53-01383,WM-TP53-01383,screening,-6.47,-3.72,0.917,0.309,0.917,0.557,0.643,0.681,0.18,0.346,0.484,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,287.1,4.3,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.8e-05,35
p.Y220C,WM-TP53-04800,WM-TP53-04800,preclinical,-6.06,-3.29,0.923,0.257,0.923,0.53,0.624,0.641,0.4,0.351,0.484,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,299.9,4.38,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.6e-05,36
p.Y220C,WM-TP53-02588,WM-TP53-02588,approved,-5.76,-3.2,0.853,0.22,0.853,0.499,0.589,0.63,0.72,0.354,0.484,0.874,"C220,T150,P151,P222,V147,L145",Pass,False,True,353.2,4.43,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.9e-05,37
p.Y220C,WM-TP53-05293,WM-TP53-05293,screening,-6.68,-3.42,1.0,0.335,1.0,0.584,0.677,0.632,0.18,0.656,0.483,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,319.7,4.76,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.3e-05,38
p.Y220C,WM-TP53-03557,WM-TP53-03557,screening,-6.26,-3.44,0.94,0.282,0.94,0.546,0.639,0.694,0.18,0.34,0.482,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,292.7,4.2,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.6e-05,39
p.Y220C,WM-TP53-02459,WM-TP53-02459,screening,-6.18,-3.2,0.993,0.272,0.993,0.549,0.65,0.631,0.18,0.369,0.482,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,361.6,4.7,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.9e-05,40
p.Y220C,WM-TP53-05932,WM-TP53-05932,preclinical,-6.63,-3.2,1.0,0.329,1.0,0.581,0.675,0.516,0.4,0.762,0.481,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,False,349.3,5.64,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.4e-05,41
p.Y220C,WM-TP53-03728,WM-TP53-03728,screening,-6.37,-3.51,0.953,0.296,0.953,0.556,0.648,0.639,0.18,0.38,0.481,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,314.4,4.18,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.1e-05,42
p.Y220C,WM-TP53-00192,WM-TP53-00192,screening,-6.11,-3.2,0.97,0.264,0.97,0.541,0.64,0.673,0.18,0.359,0.479,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,324.5,4.52,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.3e-05,43
p.Y220C,WM-TP53-05380,WM-TP53-05380,screening,-6.15,-3.34,0.937,0.269,0.937,0.538,0.632,0.704,0.18,0.337,0.478,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,286.1,4.15,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.1e-05,44
p.Y220C,WM-TP53-04561,WM-TP53-04561,screening,-6.14,-3.2,0.98,0.267,0.98,0.544,0.644,0.648,0.18,0.376,0.478,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,353.7,4.84,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.1e-05,45
p.Y220C,WM-TP53-07432,WM-TP53-07432,screening,-6.14,-3.2,0.98,0.267,0.98,0.544,0.644,0.636,0.18,0.381,0.476,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,363.0,4.93,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.1e-05,46
p.Y220C,WM-TP53-08108,WM-TP53-08108,screening,-6.11,-3.2,0.97,0.264,0.97,0.541,0.64,0.648,0.18,0.359,0.476,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,314.0,4.53,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.3e-05,47
p.Y220C,WM-TP53-02979,WM-TP53-02979,screening,-6.08,-3.2,0.96,0.26,0.96,0.537,0.635,0.683,0.18,0.356,0.476,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,305.7,4.46,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.5e-05,48
p.Y220C,WM-TP53-07895,WM-TP53-07895,screening,-6.59,-3.97,0.873,0.324,0.873,0.559,0.637,0.642,0.18,0.344,0.475,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,280.4,4.26,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.5e-05,49
p.Y220C,WM-TP53-01462,WM-TP53-01462,screening,-6.47,-3.85,0.873,0.309,0.873,0.551,0.631,0.687,0.18,0.341,0.475,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,274.5,4.22,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.8e-05,50
p.Y220C,WM-TP53-02921,WM-TP53-02921,screening,-6.37,-3.73,0.88,0.296,0.88,0.545,0.628,0.695,0.18,0.331,0.474,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,283.1,4.05,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.1e-05,51
p.Y220C,WM-TP53-03307,WM-TP53-03307,screening,-6.89,-3.24,1.0,0.361,1.0,0.599,0.688,0.533,0.18,0.767,0.472,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,348.2,5.06,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,9e-06,52
p.Y220C,WM-TP53-03770,WM-TP53-03770,screening,-6.14,-3.37,0.923,0.267,0.923,0.536,0.628,0.694,0.18,0.348,0.472,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,295.2,4.33,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.1e-05,53
p.Y220C,WM-TP53-06729,WM-TP53-06729,clinical,-6.13,-3.93,0.733,0.266,0.733,0.506,0.574,0.696,0.62,0.321,0.472,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,228.0,3.9,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.2e-05,54
p.Y220C,WM-TP53-01855,WM-TP53-01855,screening,-6.61,-4.15,0.82,0.326,0.82,0.552,0.623,0.703,0.18,0.339,0.47,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,243.6,4.19,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.4e-05,55
p.Y220C,WM-TP53-04081,WM-TP53-04081,screening,-6.01,-3.2,0.937,0.251,0.937,0.529,0.625,0.69,0.18,0.34,0.47,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,324.3,4.21,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.9e-05,56
p.Y220C,WM-TP53-05658,WM-TP53-05658,screening,-6.69,-3.41,1.0,0.336,1.0,0.585,0.678,0.559,0.18,0.736,0.469,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,310.5,5.04,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.2e-05,57
p.Y220C,WM-TP53-05156,WM-TP53-05156,clinical,-6.39,-4.38,0.67,0.299,0.67,0.515,0.57,0.681,0.62,0.293,0.469,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,237.1,3.46,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.1e-05,58
p.Y220C,WM-TP53-00578,WM-TP53-00578,screening,-6.15,-3.36,0.93,0.269,0.93,0.537,0.631,0.657,0.18,0.371,0.468,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,319.2,4.0,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.1e-05,59
p.Y220C,WM-TP53-03866,WM-TP53-03866,screening,-6.03,-3.21,0.94,0.254,0.94,0.531,0.627,0.668,0.18,0.344,0.468,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,305.3,4.26,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.8e-05,60
p.Y220C,WM-TP53-02782,WM-TP53-02782,screening,-6.5,-3.64,0.953,0.312,0.953,0.565,0.655,0.651,0.18,0.648,0.467,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,267.9,4.57,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.7e-05,61
p.Y220C,WM-TP53-02349,WM-TP53-02349,screening,-6.42,-3.92,0.833,0.302,0.833,0.541,0.617,0.706,0.18,0.312,0.467,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,279.1,3.77,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2e-05,62
p.Y220C,WM-TP53-05861,WM-TP53-05861,screening,-6.3,-3.2,1.0,0.287,1.0,0.558,0.658,0.64,0.18,0.657,0.467,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,319.8,4.8,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.4e-05,63
p.Y220C,WM-TP53-03585,WM-TP53-03585,screening,-6.58,-4.08,0.833,0.323,0.833,0.552,0.625,0.662,0.18,0.35,0.466,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,252.0,4.36,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.5e-05,64
p.Y220C,WM-TP53-01263,WM-TP53-01263,screening,-6.28,-3.62,0.887,0.285,0.887,0.54,0.625,0.679,0.18,0.37,0.466,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,290.3,3.99,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.5e-05,65
p.Y220C,WM-TP53-08335,WM-TP53-08335,screening,-6.02,-3.2,0.94,0.252,0.94,0.53,0.627,0.663,0.18,0.359,0.466,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,319.6,4.53,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.8e-05,66
p.Y220C,WM-TP53-00917,WM-TP53-00917,preclinical,-6.51,-4.28,0.743,0.314,0.743,0.534,0.597,0.654,0.4,0.333,0.464,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,238.2,4.09,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.7e-05,67
p.Y220C,WM-TP53-06983,WM-TP53-06983,screening,-6.2,-3.2,1.0,0.275,1.0,0.551,0.653,0.647,0.18,0.645,0.464,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,343.8,4.51,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.8e-05,68
p.Y220C,WM-TP53-05222,WM-TP53-05222,screening,-6.17,-3.58,0.863,0.271,0.863,0.529,0.613,0.718,0.18,0.318,0.464,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,289.5,3.86,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3e-05,69
p.Y220C,WM-TP53-01085,WM-TP53-01085,screening,-6.5,-4.07,0.81,0.312,0.81,0.543,0.615,0.699,0.18,0.323,0.463,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,265.5,3.93,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.7e-05,70
p.Y220C,WM-TP53-00188,WM-TP53-00188,screening,-6.4,-3.91,0.83,0.3,0.83,0.539,0.615,0.696,0.18,0.329,0.463,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,264.6,4.02,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2e-05,71
p.Y220C,WM-TP53-06489,WM-TP53-06489,screening,-6.13,-3.46,0.89,0.266,0.89,0.53,0.618,0.667,0.18,0.329,0.462,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,310.6,4.03,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.2e-05,72
p.Y220C,WM-TP53-00015,WM-TP53-00015,screening,-6.02,-3.2,0.94,0.252,0.94,0.53,0.627,0.621,0.18,0.36,0.461,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,354.7,4.55,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.8e-05,73
p.Y220C,WM-TP53-03847,WM-TP53-03847,screening,-6.48,-3.21,1.0,0.31,1.0,0.571,0.667,0.566,0.18,0.741,0.46,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,297.0,5.14,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.8e-05,74
p.Y220C,WM-TP53-02042,WM-TP53-02042,screening,-6.16,-3.2,0.987,0.27,0.987,0.547,0.647,0.654,0.18,0.645,0.46,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,336.9,4.51,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3e-05,75
p.Y220C,WM-TP53-02421,WM-TP53-02421,screening,-5.94,-3.2,0.913,0.243,0.913,0.52,0.615,0.684,0.18,0.342,0.46,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,263.3,4.24,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.4e-05,76
p.Y220C,WM-TP53-05149,WM-TP53-05149,preclinical,-5.77,-3.29,0.827,0.221,0.827,0.496,0.582,0.712,0.4,0.293,0.46,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,301.6,3.47,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,77
p.Y220C,WM-TP53-04813,WM-TP53-04813,screening,-6.34,-3.92,0.807,0.292,0.807,0.532,0.606,0.721,0.18,0.317,0.459,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,260.0,3.84,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.2e-05,78
p.Y220C,WM-TP53-07286,WM-TP53-07286,screening,-6.16,-3.2,0.987,0.27,0.987,0.547,0.647,0.626,0.18,0.634,0.458,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,351.2,4.99,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3e-05,79
p.Y220C,WM-TP53-08107,WM-TP53-08107,screening,-5.98,-3.2,0.927,0.248,0.927,0.525,0.621,0.637,0.18,0.359,0.458,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,362.0,4.52,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.1e-05,80
p.Y220C,WM-TP53-06058,WM-TP53-06058,screening,-5.93,-3.2,0.91,0.241,0.91,0.519,0.614,0.689,0.18,0.356,0.458,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,348.0,4.46,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,81
p.Y220C,WM-TP53-05997,WM-TP53-05997,screening,-6.44,-4.04,0.8,0.305,0.8,0.538,0.609,0.714,0.18,0.368,0.457,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,228.5,3.96,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.9e-05,82
p.Y220C,WM-TP53-00408,WM-TP53-00408,preclinical,-6.25,-4.07,0.727,0.281,0.727,0.514,0.579,0.709,0.4,0.298,0.457,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,270.2,3.55,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.6e-05,83
p.Y220C,WM-TP53-01314,WM-TP53-01314,clinical,-5.84,-3.68,0.72,0.23,0.72,0.484,0.556,0.69,0.62,0.286,0.457,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,294.0,3.36,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.2e-05,84
p.Y220C,CTRL-001,PK083,preclinical,-5.22,-3.02,0.733,0.152,0.733,0.444,0.648,0.645,0.8,0.363,0.456,0.89,"C220,T150,P151,P222,V147,L145",Pass,True,True,238.3,3.85,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Occupies the mutation-induced hydrophobic cavity and thermodynamically stabilizes the DBD,rescue-score-v1.0,"known-ligand-control,mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000148,85
p.Y220C,WM-TP53-03077,WM-TP53-03077,screening,-6.52,-3.2,1.0,0.315,1.0,0.573,0.669,0.538,0.18,0.767,0.456,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,323.2,5.08,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.6e-05,86
p.Y220C,WM-TP53-07130,WM-TP53-07130,preclinical,-6.41,-4.31,0.7,0.301,0.7,0.521,0.58,0.707,0.4,0.317,0.456,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,194.6,3.83,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,2e-05,87
p.Y220C,WM-TP53-07365,WM-TP53-07365,screening,-6.07,-3.57,0.833,0.259,0.833,0.517,0.599,0.736,0.18,0.296,0.456,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,287.2,3.51,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.5e-05,88
p.Y220C,WM-TP53-07066,WM-TP53-07066,screening,-6.23,-3.72,0.837,0.279,0.837,0.529,0.609,0.684,0.18,0.34,0.455,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,263.2,4.21,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.7e-05,89
p.Y220C,WM-TP53-04854,WM-TP53-04854,screening,-5.91,-3.26,0.883,0.239,0.883,0.514,0.605,0.704,0.18,0.328,0.455,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,297.2,4.0,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.6e-05,90
p.Y220C,WM-TP53-04087,WM-TP53-04087,preclinical,-5.77,-3.2,0.857,0.221,0.857,0.5,0.591,0.658,0.4,0.373,0.455,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,380.6,4.78,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,91
p.Y220C,WM-TP53-03335,WM-TP53-03335,screening,-6.67,-4.46,0.737,0.334,0.737,0.544,0.603,0.69,0.18,0.308,0.454,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,217.4,3.69,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.3e-05,92
p.Y220C,WM-TP53-02651,WM-TP53-02651,screening,-6.28,-3.44,0.947,0.285,0.947,0.549,0.642,0.632,0.18,0.639,0.454,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,306.2,4.38,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.5e-05,93
p.Y220C,WM-TP53-08470,WM-TP53-08470,screening,-6.48,-4.13,0.783,0.31,0.783,0.538,0.606,0.679,0.18,0.338,0.453,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,239.2,4.17,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.8e-05,94
p.Y220C,WM-TP53-04962,WM-TP53-04962,screening,-6.15,-3.28,0.957,0.269,0.957,0.541,0.638,0.653,0.18,0.633,0.453,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,314.9,4.24,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.1e-05,95
p.Y220C,WM-TP53-03571,WM-TP53-03571,screening,-5.91,-3.2,0.903,0.239,0.903,0.517,0.611,0.661,0.18,0.349,0.453,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,343.1,4.35,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.6e-05,96
p.Y220C,WM-TP53-00833,WM-TP53-00833,screening,-5.86,-3.2,0.887,0.233,0.887,0.511,0.604,0.703,0.18,0.328,0.453,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,306.9,4.0,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5e-05,97
p.Y220C,WM-TP53-05136,WM-TP53-05136,screening,-5.86,-3.2,0.887,0.233,0.887,0.511,0.604,0.701,0.18,0.329,0.453,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,308.5,4.02,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5e-05,98
p.Y220C,WM-TP53-07165,WM-TP53-07165,screening,-5.99,-3.33,0.887,0.249,0.887,0.52,0.61,0.65,0.18,0.337,0.452,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,305.6,4.16,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4e-05,99
p.Y220C,WM-TP53-02508,WM-TP53-02508,screening,-6.28,-3.88,0.8,0.285,0.8,0.527,0.601,0.699,0.18,0.325,0.451,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,222.0,3.96,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.5e-05,100
p.Y220C,WM-TP53-02245,WM-TP53-02245,clinical,-5.94,-3.2,0.913,0.243,0.913,0.52,0.615,0.52,0.62,0.759,0.451,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,False,385.6,5.57,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.4e-05,101
p.Y220C,WM-TP53-06250,WM-TP53-06250,screening,-6.02,-3.41,0.87,0.252,0.87,0.519,0.607,0.678,0.18,0.373,0.45,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,287.1,4.05,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.8e-05,102
p.Y220C,WM-TP53-00636,WM-TP53-00636,screening,-5.97,-3.35,0.873,0.246,0.873,0.516,0.605,0.667,0.18,0.333,0.45,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,277.8,4.09,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.2e-05,103
p.Y220C,WM-TP53-05692,WM-TP53-05692,screening,-5.93,-3.2,0.91,0.241,0.91,0.519,0.614,0.64,0.18,0.379,0.45,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,360.0,4.9,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,104
p.Y220C,WM-TP53-05006,WM-TP53-05006,clinical,-5.81,-3.72,0.697,0.226,0.697,0.479,0.548,0.685,0.62,0.282,0.45,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,275.5,3.3,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.5e-05,105
p.Y220C,WM-TP53-02305,WM-TP53-02305,screening,-5.87,-3.2,0.89,0.234,0.89,0.512,0.605,0.668,0.18,0.35,0.448,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,324.3,4.37,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.9e-05,106
p.Y220C,WM-TP53-00573,WM-TP53-00573,screening,-5.85,-3.2,0.883,0.231,0.883,0.51,0.602,0.688,0.18,0.347,0.448,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,309.2,4.32,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.1e-05,107
p.Y220C,WM-TP53-05742,WM-TP53-05742,screening,-5.82,-3.2,0.873,0.228,0.873,0.506,0.598,0.694,0.18,0.315,0.448,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,327.9,3.81,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.4e-05,108
p.Y220C,WM-TP53-05079,WM-TP53-05079,screening,-5.9,-3.27,0.877,0.238,0.877,0.512,0.603,0.668,0.18,0.352,0.447,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,282.8,4.41,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.7e-05,109
p.Y220C,WM-TP53-02095,WM-TP53-02095,screening,-6.22,-3.7,0.84,0.277,0.84,0.529,0.609,0.641,0.18,0.381,0.446,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,265.1,4.21,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.7e-05,110
p.Y220C,WM-TP53-04181,WM-TP53-04181,screening,-6.15,-3.77,0.793,0.269,0.793,0.517,0.592,0.726,0.18,0.333,0.446,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,232.7,4.09,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.1e-05,111
p.Y220C,WM-TP53-03998,WM-TP53-03998,screening,-6.08,-3.2,0.96,0.26,0.96,0.537,0.635,0.624,0.18,0.645,0.446,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,356.8,4.51,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.5e-05,112
p.Y220C,WM-TP53-02037,WM-TP53-02037,screening,-6.16,-3.75,0.803,0.27,0.803,0.519,0.596,0.687,0.18,0.336,0.444,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,256.3,4.13,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3e-05,113
p.Y220C,WM-TP53-01791,WM-TP53-01791,screening,-6.13,-3.65,0.827,0.266,0.827,0.52,0.601,0.637,0.18,0.318,0.444,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,294.1,3.85,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.2e-05,114
p.Y220C,WM-TP53-04799,WM-TP53-04799,screening,-6.07,-3.61,0.82,0.259,0.82,0.515,0.596,0.668,0.18,0.308,0.444,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,296.0,3.69,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.5e-05,115
p.Y220C,WM-TP53-07916,WM-TP53-07916,screening,-5.82,-3.2,0.873,0.228,0.873,0.506,0.598,0.691,0.18,0.358,0.444,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,329.8,3.77,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.4e-05,116
p.Y220C,WM-TP53-00532,WM-TP53-00532,screening,-6.19,-3.87,0.773,0.274,0.773,0.517,0.589,0.709,0.18,0.31,0.443,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,240.6,3.73,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.9e-05,117
p.Y220C,WM-TP53-00169,WM-TP53-00169,screening,-6.06,-3.57,0.83,0.257,0.83,0.516,0.598,0.691,0.18,0.376,0.443,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,272.6,4.09,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.6e-05,118
p.Y220C,WM-TP53-02504,WM-TP53-02504,screening,-5.87,-3.2,0.89,0.234,0.89,0.512,0.605,0.644,0.18,0.382,0.443,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,361.8,4.96,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.9e-05,119
p.Y220C,WM-TP53-02264,WM-TP53-02264,screening,-5.81,-3.2,0.87,0.226,0.87,0.505,0.596,0.678,0.18,0.331,0.443,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,302.1,4.05,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.5e-05,120
p.Y220C,WM-TP53-07710,WM-TP53-07710,screening,-6.15,-3.84,0.77,0.269,0.77,0.513,0.586,0.724,0.18,0.314,0.442,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,243.5,3.79,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.1e-05,121
p.Y220C,WM-TP53-07767,WM-TP53-07767,screening,-5.99,-3.47,0.84,0.249,0.84,0.513,0.597,0.664,0.18,0.34,0.442,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,279.8,4.2,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4e-05,122
p.Y220C,WM-TP53-03362,WM-TP53-03362,screening,-5.93,-3.41,0.84,0.241,0.84,0.509,0.594,0.673,0.18,0.316,0.442,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,308.6,3.82,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,123
p.Y220C,WM-TP53-06956,WM-TP53-06956,preclinical,-6.19,-4.04,0.717,0.274,0.717,0.508,0.573,0.648,0.4,0.351,0.441,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,254.2,3.65,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.9e-05,124
p.Y220C,WM-TP53-01917,WM-TP53-01917,screening,-5.89,-3.2,0.897,0.236,0.897,0.514,0.608,0.604,0.18,0.377,0.441,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,377.2,4.86,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.8e-05,125
p.Y220C,WM-TP53-03910,WM-TP53-03910,screening,-5.84,-3.37,0.823,0.23,0.823,0.5,0.585,0.73,0.18,0.313,0.441,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,269.8,3.78,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.2e-05,126
p.Y220C,WM-TP53-03680,WM-TP53-03680,clinical,-5.79,-3.83,0.653,0.224,0.653,0.471,0.535,0.733,0.62,0.326,0.441,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,244.3,3.24,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.7e-05,127
p.Y220C,WM-TP53-04225,WM-TP53-04225,screening,-6.09,-3.72,0.79,0.261,0.79,0.512,0.588,0.684,0.18,0.298,0.44,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,286.1,3.55,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.4e-05,128
p.Y220C,WM-TP53-01284,WM-TP53-01284,screening,-5.82,-3.2,0.873,0.228,0.873,0.506,0.598,0.663,0.18,0.37,0.44,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,361.9,3.98,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.4e-05,129
p.Y220C,WM-TP53-04295,WM-TP53-04295,screening,-5.81,-3.2,0.87,0.226,0.87,0.505,0.596,0.644,0.18,0.328,0.44,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,338.0,4.01,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.5e-05,130
p.Y220C,WM-TP53-00800,WM-TP53-00800,screening,-5.8,-3.2,0.867,0.225,0.867,0.504,0.595,0.668,0.18,0.363,0.439,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,376.5,4.59,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.6e-05,131
p.Y220C,WM-TP53-07657,WM-TP53-07657,screening,-5.79,-3.2,0.863,0.224,0.863,0.503,0.593,0.679,0.18,0.36,0.439,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,329.0,4.55,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.7e-05,132
p.Y220C,WM-TP53-01203,WM-TP53-01203,screening,-5.78,-3.2,0.86,0.223,0.86,0.501,0.592,0.662,0.18,0.329,0.438,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,334.7,4.03,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,133
p.Y220C,WM-TP53-05961,WM-TP53-05961,screening,-5.78,-3.2,0.86,0.223,0.86,0.501,0.592,0.675,0.18,0.352,0.438,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,316.0,3.67,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,134
p.Y220C,WM-TP53-01074,WM-TP53-01074,screening,-5.92,-3.43,0.83,0.24,0.83,0.506,0.591,0.667,0.18,0.336,0.437,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,281.8,4.13,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,135
p.Y220C,WM-TP53-01238,WM-TP53-01238,screening,-5.87,-3.21,0.887,0.234,0.887,0.512,0.604,0.594,0.18,0.382,0.436,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,300.4,4.22,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.9e-05,136
p.Y220C,WM-TP53-04044,WM-TP53-04044,screening,-5.79,-3.2,0.863,0.224,0.863,0.503,0.593,0.66,0.18,0.366,0.436,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,352.5,3.92,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.7e-05,137
p.Y220C,WM-TP53-03947,WM-TP53-03947,screening,-5.76,-3.2,0.853,0.22,0.853,0.499,0.589,0.67,0.18,0.337,0.436,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,321.8,4.16,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.9e-05,138
p.Y220C,WM-TP53-00328,WM-TP53-00328,screening,-6.53,-4.5,0.677,0.316,0.677,0.525,0.579,0.704,0.18,0.294,0.435,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,224.7,3.49,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.6e-05,139
p.Y220C,WM-TP53-07021,WM-TP53-07021,screening,-6.17,-3.93,0.747,0.271,0.747,0.511,0.58,0.693,0.18,0.284,0.435,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,281.6,3.34,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3e-05,140
p.Y220C,WM-TP53-07425,WM-TP53-07425,screening,-6.16,-3.2,0.987,0.27,0.987,0.547,0.647,0.52,0.18,0.763,0.435,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,357.4,5.67,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3e-05,141
p.Y220C,WM-TP53-04480,WM-TP53-04480,screening,-5.8,-3.2,0.867,0.225,0.867,0.504,0.595,0.65,0.18,0.378,0.435,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,348.7,4.87,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.6e-05,142
p.Y220C,WM-TP53-05728,WM-TP53-05728,screening,-6.39,-4.31,0.693,0.299,0.693,0.518,0.576,0.715,0.18,0.296,0.434,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,246.9,3.51,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.1e-05,143
p.Y220C,WM-TP53-05480,WM-TP53-05480,screening,-6.03,-3.77,0.753,0.254,0.753,0.503,0.575,0.716,0.18,0.277,0.434,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,292.2,3.23,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.8e-05,144
p.Y220C,WM-TP53-01044,WM-TP53-01044,screening,-5.97,-3.2,0.923,0.246,0.923,0.524,0.619,0.644,0.18,0.654,0.434,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,363.3,4.71,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.2e-05,145
p.Y220C,WM-TP53-05661,WM-TP53-05661,screening,-5.96,-3.2,0.92,0.245,0.92,0.523,0.618,0.645,0.18,0.636,0.434,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,349.9,4.3,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.2e-05,146
p.Y220C,WM-TP53-08307,WM-TP53-08307,screening,-5.77,-3.2,0.857,0.221,0.857,0.5,0.591,0.658,0.18,0.366,0.433,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,322.1,4.64,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,147
p.Y220C,WM-TP53-02677,WM-TP53-02677,screening,-6.22,-4.02,0.733,0.277,0.733,0.513,0.579,0.704,0.18,0.329,0.432,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,216.0,4.03,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.7e-05,148
p.Y220C,WM-TP53-02521,WM-TP53-02521,screening,-5.78,-3.3,0.827,0.223,0.827,0.496,0.583,0.673,0.18,0.32,0.432,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,301.7,3.88,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,149
p.Y220C,WM-TP53-07170,WM-TP53-07170,screening,-5.78,-3.2,0.86,0.223,0.86,0.501,0.592,0.632,0.18,0.356,0.432,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,344.8,4.46,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,150
p.Y220C,WM-TP53-02976,WM-TP53-02976,screening,-5.88,-3.2,0.893,0.235,0.893,0.513,0.606,0.535,0.18,0.38,0.431,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,328.0,4.91,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.9e-05,151
p.Y220C,CTRL-002,PK7088,preclinical,-5.26,-3.06,0.733,0.157,0.733,0.447,0.65,0.609,0.8,0.653,0.43,0.89,"C220,T150,P151,P222,V147,L145",Pass,True,True,364.2,4.7,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Occupies the mutation-induced hydrophobic cavity and thermodynamically stabilizes the DBD,rescue-score-v1.0,"known-ligand-control,mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000138,152
p.Y220C,WM-TP53-03139,WM-TP53-03139,screening,-6.06,-3.74,0.773,0.257,0.773,0.508,0.582,0.688,0.18,0.36,0.43,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,251.6,3.81,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.6e-05,153
p.Y220C,WM-TP53-00428,WM-TP53-00428,screening,-6.35,-4.24,0.703,0.294,0.703,0.517,0.577,0.663,0.18,0.297,0.429,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,254.6,3.54,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.2e-05,154
p.Y220C,WM-TP53-04762,WM-TP53-04762,screening,-6.5,-4.54,0.653,0.312,0.653,0.52,0.571,0.7,0.18,0.287,0.428,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,215.6,3.37,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.7e-05,155
p.Y220C,WM-TP53-07198,WM-TP53-07198,screening,-6.15,-3.92,0.743,0.269,0.743,0.509,0.578,0.675,0.18,0.323,0.428,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,250.6,3.93,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.1e-05,156
p.Y220C,WM-TP53-03814,WM-TP53-03814,screening,-5.9,-3.66,0.747,0.238,0.747,0.493,0.567,0.739,0.18,0.302,0.428,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,270.3,3.6,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.7e-05,157
p.Y220C,WM-TP53-02186,WM-TP53-02186,screening,-5.76,-3.2,0.853,0.22,0.853,0.499,0.589,0.631,0.18,0.376,0.428,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,361.1,4.84,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.9e-05,158
p.Y220C,WM-TP53-07508,WM-TP53-07508,screening,-6.06,-3.93,0.71,0.257,0.71,0.498,0.564,0.749,0.18,0.296,0.427,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,245.3,3.52,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.6e-05,159
p.Y220C,WM-TP53-00860,WM-TP53-00860,preclinical,-5.85,-3.84,0.67,0.231,0.67,0.478,0.542,0.719,0.4,0.292,0.427,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,224.4,3.45,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.1e-05,160
p.Y220C,WM-TP53-07714,WM-TP53-07714,screening,-5.84,-3.5,0.78,0.23,0.78,0.493,0.573,0.697,0.18,0.308,0.427,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,284.9,3.69,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.2e-05,161
p.Y220C,WM-TP53-03151,WM-TP53-03151,screening,-6.05,-3.87,0.727,0.256,0.727,0.5,0.569,0.704,0.18,0.294,0.426,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,269.3,3.48,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.6e-05,162
p.Y220C,WM-TP53-08399,WM-TP53-08399,screening,-5.99,-3.71,0.76,0.249,0.76,0.501,0.575,0.679,0.18,0.317,0.426,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,269.4,3.83,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4e-05,163
p.Y220C,WM-TP53-02905,WM-TP53-02905,screening,-6.03,-3.2,0.943,0.254,0.943,0.531,0.628,0.561,0.18,0.745,0.424,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,377.6,5.24,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.8e-05,164
p.Y220C,WM-TP53-03033,WM-TP53-03033,screening,-5.92,-3.71,0.737,0.24,0.737,0.493,0.565,0.745,0.18,0.341,0.424,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,249.5,3.48,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,165
p.Y220C,WM-TP53-03914,WM-TP53-03914,screening,-5.94,-3.69,0.75,0.243,0.75,0.496,0.569,0.709,0.18,0.34,0.423,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,282.8,3.47,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.4e-05,166
p.Y220C,WM-TP53-07234,WM-TP53-07234,screening,-5.9,-3.2,0.9,0.238,0.9,0.516,0.609,0.621,0.18,0.649,0.423,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,321.4,4.59,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.7e-05,167
p.Y220C,WM-TP53-04283,WM-TP53-04283,screening,-6.43,-4.47,0.653,0.304,0.653,0.515,0.567,0.69,0.18,0.312,0.422,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,188.1,3.77,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,1.9e-05,168
p.Y220C,WM-TP53-04731,WM-TP53-04731,screening,-6.21,-4.01,0.733,0.276,0.733,0.512,0.579,0.649,0.18,0.367,0.422,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,241.8,3.93,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.8e-05,169
p.Y220C,WM-TP53-05020,WM-TP53-05020,screening,-6.2,-3.4,0.933,0.275,0.933,0.541,0.634,0.424,0.18,0.642,0.421,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,317.6,4.42,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.8e-05,170
p.Y220C,WM-TP53-05685,WM-TP53-05685,screening,-6.08,-3.92,0.72,0.26,0.72,0.501,0.568,0.681,0.18,0.357,0.418,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,246.9,3.76,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.5e-05,171
p.Y220C,WM-TP53-00311,WM-TP53-00311,screening,-6.05,-3.97,0.693,0.256,0.693,0.495,0.559,0.711,0.18,0.299,0.418,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,256.8,3.56,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.6e-05,172
p.Y220C,WM-TP53-08308,WM-TP53-08308,screening,-5.88,-3.76,0.707,0.235,0.707,0.485,0.554,0.732,0.18,0.282,0.417,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,257.9,3.31,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.9e-05,173
p.Y220C,WM-TP53-03796,WM-TP53-03796,preclinical,-5.85,-3.2,0.883,0.231,0.883,0.51,0.602,0.529,0.4,0.773,0.417,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,False,359.6,5.25,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.1e-05,174
p.Y220C,WM-TP53-04997,WM-TP53-04997,screening,-5.79,-3.47,0.773,0.224,0.773,0.489,0.568,0.68,0.18,0.359,0.417,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,272.6,3.79,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.7e-05,175
p.Y220C,WM-TP53-03753,WM-TP53-03753,screening,-6.0,-3.63,0.79,0.25,0.79,0.506,0.584,0.562,0.18,0.372,0.416,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,278.5,4.03,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4e-05,176
p.Y220C,WM-TP53-04896,WM-TP53-04896,preclinical,-5.8,-3.86,0.647,0.225,0.647,0.471,0.533,0.675,0.4,0.269,0.415,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,274.8,3.11,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.6e-05,177
p.Y220C,WM-TP53-01656,WM-TP53-01656,screening,-5.76,-3.45,0.77,0.22,0.77,0.486,0.566,0.676,0.18,0.357,0.415,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,273.2,3.75,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.9e-05,178
p.Y220C,WM-TP53-01629,WM-TP53-01629,preclinical,-6.02,-4.26,0.587,0.252,0.587,0.477,0.528,0.699,0.4,0.273,0.413,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,233.7,3.17,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.8e-05,179
p.Y220C,WM-TP53-05772,WM-TP53-05772,screening,-5.84,-3.73,0.703,0.23,0.703,0.482,0.551,0.716,0.18,0.276,0.413,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,275.9,3.21,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.2e-05,180
p.Y220C,WM-TP53-05502,WM-TP53-05502,screening,-5.79,-3.2,0.863,0.224,0.863,0.503,0.593,0.647,0.18,0.636,0.413,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,378.5,4.31,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.7e-05,181
p.Y220C,WM-TP53-01121,WM-TP53-01121,screening,-6.31,-3.7,0.87,0.289,0.87,0.539,0.622,0.419,0.18,0.62,0.412,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,268.2,4.72,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.3e-05,182
p.Y220C,WM-TP53-06522,WM-TP53-06522,screening,-5.79,-3.55,0.747,0.224,0.747,0.485,0.561,0.658,0.18,0.351,0.409,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,263.1,3.65,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.7e-05,183
p.Y220C,WM-TP53-05787,WM-TP53-05787,screening,-5.96,-4.0,0.653,0.245,0.653,0.483,0.543,0.724,0.18,0.289,0.407,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,227.9,3.41,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.2e-05,184
p.Y220C,WM-TP53-04920,WM-TP53-04920,screening,-5.92,-3.95,0.657,0.24,0.657,0.481,0.542,0.722,0.18,0.266,0.407,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,269.2,3.05,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,185
p.Y220C,WM-TP53-01606,WM-TP53-01606,screening,-5.78,-3.2,0.86,0.223,0.86,0.501,0.592,0.619,0.18,0.656,0.407,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,339.0,4.75,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,186
p.Y220C,WM-TP53-03194,WM-TP53-03194,screening,-5.99,-4.04,0.65,0.249,0.65,0.484,0.544,0.71,0.18,0.282,0.406,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,244.3,3.31,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4e-05,187
p.Y220C,WM-TP53-03347,WM-TP53-03347,preclinical,-5.93,-4.27,0.553,0.241,0.553,0.466,0.514,0.738,0.4,0.266,0.406,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,191.8,3.06,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,mutant-preferring,No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,188
p.Y220C,WM-TP53-03004,WM-TP53-03004,screening,-5.78,-3.71,0.69,0.223,0.69,0.476,0.544,0.711,0.18,0.289,0.406,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,260.2,3.41,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,189
p.Y220C,WM-TP53-04395,WM-TP53-04395,screening,-5.76,-3.68,0.693,0.22,0.693,0.475,0.544,0.72,0.18,0.303,0.405,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,244.6,3.62,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.9e-05,190
p.Y220C,WM-TP53-01324,WM-TP53-01324,screening,-5.83,-3.2,0.877,0.229,0.877,0.507,0.599,0.529,0.18,0.641,0.403,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,318.2,4.41,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.3e-05,191
p.Y220C,WM-TP53-01318,WM-TP53-01318,screening,-5.99,-4.13,0.62,0.249,0.62,0.48,0.536,0.736,0.18,0.286,0.402,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,201.6,3.36,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4e-05,192
p.Y220C,WM-TP53-04053,WM-TP53-04053,screening,-5.93,-3.92,0.67,0.241,0.67,0.483,0.546,0.683,0.18,0.349,0.399,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,213.9,3.62,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,193
p.Y220C,WM-TP53-05017,WM-TP53-05017,screening,-5.92,-4.06,0.62,0.24,0.62,0.475,0.532,0.745,0.18,0.285,0.399,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,211.9,3.35,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,194
p.Y220C,WM-TP53-03638,WM-TP53-03638,screening,-5.89,-4.01,0.627,0.236,0.627,0.474,0.532,0.735,0.18,0.283,0.399,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,220.1,3.32,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.8e-05,195
p.Y220C,WM-TP53-01343,WM-TP53-01343,screening,-6.21,-4.27,0.647,0.276,0.647,0.499,0.554,0.595,0.18,0.328,0.398,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,181.1,4.01,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,2.8e-05,196
p.Y220C,WM-TP53-01861,WM-TP53-01861,screening,-6.13,-4.38,0.583,0.266,0.583,0.484,0.532,0.716,0.18,0.287,0.396,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,3.38,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.2e-05,197
p.Y220C,WM-TP53-07689,WM-TP53-07689,screening,-5.8,-3.2,0.867,0.225,0.867,0.504,0.595,0.564,0.18,0.741,0.396,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,379.6,5.13,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.6e-05,198
p.Y220C,WM-TP53-00765,WM-TP53-00765,screening,-5.88,-3.87,0.67,0.235,0.67,0.48,0.544,0.673,0.18,0.37,0.394,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,3.99,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.9e-05,199
p.Y220C,WM-TP53-04422,WM-TP53-04422,screening,-5.85,-3.2,0.883,0.231,0.883,0.51,0.602,0.516,0.18,0.785,0.393,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,355.4,5.68,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.1e-05,200
p.Y220C,WM-TP53-01777,WM-TP53-01777,preclinical,-5.78,-4.19,0.53,0.223,0.53,0.452,0.5,0.726,0.4,0.303,0.39,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,199.6,2.89,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,201
p.Y220C,WM-TP53-01421,WM-TP53-01421,screening,-5.86,-3.79,0.69,0.233,0.69,0.481,0.548,0.561,0.18,0.321,0.389,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,233.3,3.9,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5e-05,202
p.Y220C,WM-TP53-01693,WM-TP53-01693,screening,-5.78,-3.2,0.86,0.223,0.86,0.501,0.592,0.538,0.18,0.758,0.389,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,357.0,5.56,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,203
p.Y220C,WM-TP53-00483,WM-TP53-00483,screening,-5.78,-3.2,0.86,0.223,0.86,0.501,0.592,0.428,0.18,0.611,0.387,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,356.3,4.56,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,204
p.Y220C,WM-TP53-03381,WM-TP53-03381,screening,-5.76,-3.2,0.853,0.22,0.853,0.499,0.589,0.543,0.18,0.754,0.387,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,401.6,5.45,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.9e-05,205
p.Y220C,WM-TP53-05556,WM-TP53-05556,preclinical,-5.82,-4.39,0.477,0.228,0.477,0.447,0.487,0.749,0.4,0.25,0.386,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,2.8,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,5.4e-05,206
p.Y220C,WM-TP53-06683,WM-TP53-06683,screening,-5.82,-4.12,0.567,0.228,0.567,0.46,0.512,0.742,0.18,0.282,0.382,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,3.31,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.4e-05,207
p.Y220C,WM-TP53-03867,WM-TP53-03867,screening,-5.8,-4.1,0.567,0.225,0.567,0.459,0.511,0.724,0.18,0.256,0.381,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,245.4,2.9,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.6e-05,208
p.Y220C,WM-TP53-07341,WM-TP53-07341,screening,-5.79,-4.05,0.58,0.224,0.58,0.46,0.514,0.69,0.18,0.3,0.376,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,250.9,2.84,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.7e-05,209
p.Y220C,WM-TP53-07201,WM-TP53-07201,screening,-5.8,-4.25,0.517,0.225,0.517,0.451,0.497,0.758,0.18,0.234,0.375,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,219.3,2.54,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.6e-05,210
p.Y220C,WM-TP53-01500,WM-TP53-01500,screening,-5.84,-4.33,0.503,0.23,0.503,0.452,0.495,0.765,0.18,0.227,0.374,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,204.3,2.4,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,5.2e-05,211
p.Y220C,WM-TP53-07282,WM-TP53-07282,screening,-6.08,-4.41,0.557,0.26,0.557,0.477,0.523,0.583,0.18,0.28,0.373,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,209.0,3.27,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.5e-05,212
p.Y220C,WM-TP53-03034,WM-TP53-03034,screening,-5.99,-4.42,0.523,0.249,0.523,0.465,0.508,0.709,0.18,0.304,0.373,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,195.0,2.91,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,4e-05,213
p.Y220C,WM-TP53-03775,WM-TP53-03775,screening,-5.8,-4.19,0.537,0.225,0.537,0.454,0.503,0.71,0.18,0.304,0.368,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,230.9,2.91,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,5.6e-05,214
p.Y220C,WM-TP53-00323,WM-TP53-00323,screening,-6.01,-3.86,0.717,0.251,0.717,0.496,0.564,0.459,0.18,0.619,0.366,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,252.5,3.97,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.9e-05,215
p.Y220C,WM-TP53-08367,WM-TP53-08367,screening,-6.04,-4.48,0.52,0.255,0.52,0.468,0.51,0.593,0.18,0.279,0.363,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,3.25,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,3.7e-05,216
p.Y220C,WM-TP53-08077,WM-TP53-08077,screening,-5.92,-4.19,0.577,0.24,0.577,0.469,0.52,0.548,0.18,0.336,0.361,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,212.9,3.41,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,4.5e-05,217
p.Y220C,WM-TP53-06794,WM-TP53-06794,screening,-5.86,-4.27,0.53,0.233,0.53,0.457,0.504,0.623,0.18,0.284,0.36,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,3.33,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,5e-05,218
p.Y220C,WM-TP53-00954,WM-TP53-00954,screening,-5.85,-3.77,0.693,0.231,0.693,0.481,0.549,0.488,0.18,0.57,0.36,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,255.6,3.88,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.1e-05,219
p.Y220C,WM-TP53-07944,WM-TP53-07944,screening,-5.78,-4.0,0.593,0.223,0.593,0.461,0.517,0.521,0.18,0.55,0.338,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,213.1,3.58,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.8e-05,220
p.Y220S,CTRL-004,PC14586,clinical,-11.08,-8.88,0.733,0.885,0.733,0.847,0.918,0.599,0.88,0.388,0.72,0.906,"C220,T150,P151,P222,V147,L145",Pass,True,False,548.6,3.4,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Occupies the mutation-induced hydrophobic cavity and thermodynamically stabilizes the DBD,rescue-score-v1.0,"known-ligand-control,mutant-preferring,strong-mutant-binding,stable-contacts,developability-risk,repurposing-eligible",Hold,Orthogonal rescoring / extra MD replica and ADMET triage before wet-lab slot,0.0,1
p.Y220S,CTRL-003,PK11000,preclinical,-6.79,-4.59,0.733,0.349,0.733,0.552,0.698,0.854,0.8,0.171,0.564,0.89,"C220,T150,P151,P222,V147,L145",Pass,True,True,236.6,1.15,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Occupies the mutation-induced hydrophobic cavity and thermodynamically stabilizes the DBD,rescue-score-v1.0,"known-ligand-control,mutant-preferring",No-go,Do not advance; revisit pocket hypothesis or chemotype,1e-05,2
p.Y220S,WM-TP53-06487,WM-TP53-06487,screening,-6.02,-3.48,0.847,0.252,0.847,0.516,0.571,0.637,0.18,0.382,0.434,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,302.0,4.96,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,3.8e-05,3
p.Y220S,WM-TP53-06028,WM-TP53-06028,screening,-5.83,-3.22,0.87,0.229,0.87,0.506,0.567,0.644,0.18,0.374,0.433,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,292.0,4.79,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,5.3e-05,4
p.Y220S,WM-TP53-00860,WM-TP53-00860,preclinical,-5.69,-3.84,0.617,0.211,0.617,0.459,0.489,0.719,0.4,0.292,0.402,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,224.4,3.45,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,6.7e-05,5
p.Y220S,WM-TP53-04481,WM-TP53-04481,preclinical,-5.28,-3.27,0.67,0.16,0.67,0.439,0.483,0.711,0.4,0.321,0.393,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,275.4,3.9,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000134,6
p.Y220S,WM-TP53-06555,WM-TP53-06555,screening,-5.25,-3.2,0.683,0.156,0.683,0.438,0.485,0.719,0.18,0.329,0.373,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,265.4,4.03,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000141,7
p.Y220S,CTRL-001,PK083,preclinical,-4.57,-3.0,0.523,0.071,0.523,0.368,0.526,0.645,0.8,0.363,0.371,0.89,"C220,T150,P151,P222,V147,L145",Pass,True,True,238.3,3.85,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Occupies the mutation-induced hydrophobic cavity and thermodynamically stabilizes the DBD,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000444,8
p.Y220S,WM-TP53-05365,WM-TP53-05365,screening,-5.31,-3.32,0.663,0.164,0.663,0.44,0.483,0.694,0.18,0.366,0.365,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,269.4,3.91,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000127,9
p.Y220S,WM-TP53-05841,WM-TP53-05841,clinical,-5.16,-3.81,0.45,0.145,0.45,0.397,0.415,0.731,0.62,0.249,0.364,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,245.7,2.79,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000164,10
p.Y220S,WM-TP53-01421,WM-TP53-01421,screening,-5.66,-3.79,0.623,0.208,0.623,0.458,0.49,0.561,0.18,0.321,0.359,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,233.3,3.9,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,7e-05,11
p.Y220S,WM-TP53-00146,WM-TP53-00146,screening,-5.39,-3.78,0.537,0.174,0.537,0.426,0.452,0.769,0.18,0.273,0.355,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,204.8,3.17,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000111,12
p.Y220S,WM-TP53-07201,WM-TP53-07201,screening,-5.67,-4.25,0.473,0.209,0.473,0.436,0.448,0.758,0.18,0.234,0.354,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,219.3,2.54,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,6.9e-05,13
p.Y220S,WM-TP53-00707,WM-TP53-00707,screening,-5.24,-3.62,0.54,0.155,0.54,0.416,0.445,0.792,0.18,0.24,0.354,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,260.5,2.63,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000143,14
p.Y220S,CTRL-002,PK7088,preclinical,-4.61,-3.0,0.537,0.076,0.537,0.372,0.532,0.609,0.8,0.653,0.348,0.89,"C220,T150,P151,P222,V147,L145",Pass,True,True,364.2,4.7,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Occupies the mutation-induced hydrophobic cavity and thermodynamically stabilizes the DBD,rescue-score-v1.0,"known-ligand-control,developability-risk",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000415,15
p.Y220S,WM-TP53-02305,WM-TP53-02305,screening,-5.11,-3.2,0.637,0.139,0.637,0.422,0.465,0.668,0.18,0.35,0.348,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,324.3,4.37,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000178,16
p.Y220S,WM-TP53-01676,WM-TP53-01676,clinical,-4.68,-3.2,0.493,0.085,0.493,0.371,0.403,0.708,0.62,0.333,0.344,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,278.8,3.35,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000369,17
p.Y220S,WM-TP53-06079,WM-TP53-06079,screening,-5.0,-3.4,0.533,0.125,0.533,0.399,0.431,0.778,0.18,0.257,0.338,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,259.7,2.91,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000215,18
p.Y220S,WM-TP53-03546,WM-TP53-03546,screening,-4.92,-3.33,0.53,0.115,0.53,0.393,0.426,0.757,0.18,0.272,0.33,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,242.1,3.14,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000246,19
p.Y220S,WM-TP53-07286,WM-TP53-07286,screening,-5.17,-3.2,0.657,0.146,0.657,0.429,0.474,0.626,0.18,0.634,0.328,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,351.2,4.99,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000161,20
p.Y220S,WM-TP53-07949,WM-TP53-07949,approved,-4.48,-3.22,0.42,0.06,0.42,0.346,0.372,0.651,0.72,0.244,0.327,0.874,"C220,T150,P151,P222,V147,L145",Pass,False,True,255.6,2.69,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000517,21
p.Y220S,WM-TP53-05416,WM-TP53-05416,screening,-4.9,-3.2,0.567,0.113,0.567,0.397,0.435,0.666,0.18,0.328,0.323,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,329.0,4.0,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"mutant-preferring,developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000254,22
p.Y220S,WM-TP53-05637,WM-TP53-05637,screening,-4.96,-3.5,0.487,0.12,0.487,0.389,0.416,0.716,0.18,0.26,0.318,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,191.7,2.96,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00023,23
p.Y220S,WM-TP53-05977,WM-TP53-05977,screening,-4.85,-3.31,0.513,0.106,0.513,0.385,0.417,0.705,0.18,0.266,0.317,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,301.7,3.06,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000277,24
p.Y220S,WM-TP53-02951,WM-TP53-02951,screening,-4.81,-3.2,0.537,0.101,0.537,0.386,0.422,0.681,0.18,0.334,0.313,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,327.6,4.1,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000296,25
p.Y220S,WM-TP53-07575,WM-TP53-07575,preclinical,-4.5,-3.2,0.433,0.062,0.433,0.349,0.377,0.786,0.4,0.275,0.313,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,299.7,3.2,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.0005,26
p.Y220S,WM-TP53-02475,WM-TP53-02475,screening,-4.68,-3.2,0.493,0.085,0.493,0.371,0.403,0.756,0.18,0.292,0.309,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,268.7,3.45,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000369,27
p.Y220S,WM-TP53-01438,WM-TP53-01438,screening,-5.04,-3.93,0.37,0.13,0.37,0.377,0.387,0.779,0.18,0.212,0.304,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,198.0,2.13,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000201,28
p.Y220S,WM-TP53-06623,WM-TP53-06623,screening,-4.86,-3.57,0.43,0.108,0.43,0.374,0.395,0.727,0.18,0.242,0.302,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,244.5,2.67,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000272,29
p.Y220S,WM-TP53-07609,WM-TP53-07609,screening,-4.57,-3.2,0.457,0.071,0.457,0.358,0.387,0.763,0.18,0.245,0.299,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,275.3,2.72,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000444,30
p.Y220S,WM-TP53-03121,WM-TP53-03121,screening,-4.62,-3.2,0.473,0.078,0.473,0.364,0.394,0.687,0.18,0.295,0.293,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,295.8,3.5,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000408,31
p.Y220S,WM-TP53-02798,WM-TP53-02798,screening,-4.58,-3.33,0.417,0.073,0.417,0.352,0.376,0.767,0.18,0.225,0.292,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,243.8,2.37,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000437,32
p.Y220S,WM-TP53-02322,WM-TP53-02322,preclinical,-4.73,-3.97,0.253,0.091,0.253,0.338,0.338,0.812,0.4,0.176,0.29,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,1.28,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000339,33
p.Y220S,WM-TP53-03410,WM-TP53-03410,screening,-4.55,-3.35,0.4,0.069,0.4,0.348,0.37,0.79,0.18,0.229,0.289,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,185.6,2.44,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000459,34
p.Y220S,WM-TP53-02186,WM-TP53-02186,screening,-4.69,-3.2,0.497,0.086,0.497,0.372,0.405,0.631,0.18,0.376,0.288,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,361.1,4.84,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000363,35
p.Y220S,WM-TP53-04090,WM-TP53-04090,screening,-4.68,-3.2,0.493,0.085,0.493,0.371,0.403,0.593,0.18,0.328,0.286,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,308.3,4.01,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000369,36
p.Y220S,WM-TP53-04923,WM-TP53-04923,preclinical,-4.32,-3.2,0.373,0.04,0.373,0.328,0.351,0.735,0.4,0.252,0.286,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,273.1,2.83,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000677,37
p.Y220S,WM-TP53-03444,WM-TP53-03444,screening,-4.59,-3.2,0.463,0.074,0.463,0.36,0.39,0.681,0.18,0.33,0.285,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,310.9,3.31,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000429,38
p.Y220S,WM-TP53-04430,WM-TP53-04430,preclinical,-4.4,-3.2,0.4,0.05,0.4,0.338,0.363,0.696,0.4,0.325,0.285,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,337.5,3.96,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000592,39
p.Y220S,WM-TP53-00367,WM-TP53-00367,screening,-4.8,-3.66,0.38,0.1,0.38,0.362,0.377,0.638,0.18,0.228,0.277,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,248.0,2.43,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000301,40
p.Y220S,WM-TP53-01795,WM-TP53-01795,screening,-4.94,-3.92,0.34,0.118,0.34,0.366,0.373,0.61,0.18,0.217,0.272,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,233.2,2.22,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000238,41
p.Y220S,WM-TP53-06997,WM-TP53-06997,screening,-4.41,-3.2,0.403,0.051,0.403,0.339,0.364,0.703,0.18,0.237,0.272,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,258.1,2.58,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000582,42
p.Y220S,WM-TP53-06249,WM-TP53-06249,screening,-4.45,-3.38,0.357,0.056,0.357,0.334,0.353,0.76,0.18,0.217,0.271,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,273.1,2.22,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000544,43
p.Y220S,WM-TP53-04056,WM-TP53-04056,screening,-4.36,-3.37,0.33,0.045,0.33,0.324,0.341,0.798,0.18,0.198,0.267,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,244.9,1.84,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000633,44
p.Y220S,WM-TP53-05501,WM-TP53-05501,clinical,-3.88,-3.2,0.227,0.0,0.227,0.284,0.294,0.799,0.62,0.231,0.267,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,297.2,2.47,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001424,45
p.Y220S,WM-TP53-06810,WM-TP53-06810,clinical,-4.39,-3.2,0.397,0.049,0.397,0.336,0.361,0.508,0.62,0.543,0.266,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,2.74,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000602,46
p.Y220S,WM-TP53-08000,WM-TP53-08000,screening,-4.42,-3.3,0.373,0.052,0.373,0.335,0.356,0.688,0.18,0.224,0.265,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,235.4,2.36,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000572,47
p.Y220S,WM-TP53-04260,WM-TP53-04260,screening,-4.35,-3.2,0.383,0.044,0.383,0.332,0.355,0.719,0.18,0.288,0.263,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,319.5,3.4,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000644,48
p.Y220S,WM-TP53-04600,WM-TP53-04600,screening,-4.33,-3.35,0.327,0.041,0.327,0.322,0.339,0.791,0.18,0.204,0.263,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,213.7,1.97,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000666,49
p.Y220S,WM-TP53-05331,WM-TP53-05331,screening,-4.47,-3.41,0.353,0.059,0.353,0.335,0.353,0.688,0.18,0.222,0.262,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,246.1,2.31,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000526,50
p.Y220S,WM-TP53-06521,WM-TP53-06521,clinical,-4.17,-3.2,0.323,0.021,0.323,0.31,0.329,0.563,0.62,0.33,0.262,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,302.6,3.3,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000873,51
p.Y220S,WM-TP53-02764,WM-TP53-02764,screening,-4.51,-3.67,0.28,0.064,0.28,0.327,0.335,0.781,0.18,0.191,0.26,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,221.3,1.67,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000491,52
p.Y220S,WM-TP53-07898,WM-TP53-07898,screening,-4.69,-3.31,0.46,0.086,0.46,0.366,0.394,0.529,0.18,0.512,0.256,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,293.4,2.99,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000363,53
p.Y220S,WM-TP53-05926,WM-TP53-05926,screening,-4.33,-3.22,0.37,0.041,0.37,0.328,0.35,0.66,0.18,0.224,0.256,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,246.6,2.35,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000666,54
p.Y220S,WM-TP53-06198,WM-TP53-06198,screening,-4.24,-3.2,0.347,0.03,0.347,0.319,0.34,0.752,0.18,0.249,0.256,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,306.3,2.79,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000775,55
p.Y220S,WM-TP53-06538,WM-TP53-06538,screening,-4.23,-3.2,0.343,0.029,0.343,0.317,0.338,0.742,0.18,0.222,0.255,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,246.6,2.32,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000789,56
p.Y220S,WM-TP53-02050,WM-TP53-02050,screening,-4.33,-3.2,0.377,0.041,0.377,0.329,0.352,0.7,0.18,0.329,0.254,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,364.1,4.03,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000666,57
p.Y220S,WM-TP53-01693,WM-TP53-01693,screening,-4.74,-3.2,0.513,0.093,0.513,0.378,0.412,0.538,0.18,0.758,0.253,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,357.0,5.56,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000333,58
p.Y220S,WM-TP53-00214,WM-TP53-00214,screening,-4.24,-3.2,0.347,0.03,0.347,0.319,0.34,0.742,0.18,0.267,0.253,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,243.1,2.33,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000775,59
p.Y220S,WM-TP53-00877,WM-TP53-00877,clinical,-3.7,-3.2,0.167,0.0,0.167,0.275,0.277,0.807,0.62,0.228,0.253,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,316.9,2.42,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00193,60
p.Y220S,WM-TP53-06589,WM-TP53-06589,screening,-4.61,-3.27,0.447,0.076,0.447,0.359,0.386,0.547,0.18,0.506,0.252,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,256.5,2.89,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000415,61
p.Y220S,WM-TP53-08238,WM-TP53-08238,clinical,-3.74,-3.2,0.18,0.0,0.18,0.277,0.28,0.782,0.62,0.243,0.252,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,297.7,2.68,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001804,62
p.Y220S,WM-TP53-05280,WM-TP53-05280,screening,-4.69,-3.95,0.247,0.086,0.247,0.334,0.334,0.699,0.18,0.188,0.25,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,1.59,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000363,63
p.Y220S,WM-TP53-01625,WM-TP53-01625,screening,-4.19,-3.21,0.327,0.024,0.327,0.312,0.331,0.694,0.18,0.212,0.245,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,237.4,2.12,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000844,64
p.Y220S,WM-TP53-04991,WM-TP53-04991,screening,-4.3,-3.41,0.297,0.037,0.297,0.315,0.328,0.68,0.18,0.202,0.241,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,231.0,1.92,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000701,65
p.Y220S,WM-TP53-06266,WM-TP53-06266,screening,-4.2,-3.2,0.333,0.025,0.333,0.314,0.334,0.708,0.18,0.317,0.24,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,344.6,3.83,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00083,66
p.Y220S,WM-TP53-03172,WM-TP53-03172,screening,-4.04,-3.26,0.26,0.005,0.26,0.292,0.305,0.797,0.18,0.189,0.236,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,241.8,1.63,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001087,67
p.Y220S,WM-TP53-03087,WM-TP53-03087,screening,-4.39,-3.22,0.39,0.049,0.39,0.335,0.359,0.59,0.18,0.486,0.235,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,250.6,2.57,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000602,68
p.Y220S,WM-TP53-04294,WM-TP53-04294,screening,-3.97,-3.2,0.257,0.0,0.257,0.289,0.302,0.801,0.18,0.201,0.233,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,251.6,1.9,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001223,69
p.Y220S,WM-TP53-01914,WM-TP53-01914,clinical,-3.91,-3.2,0.237,0.0,0.237,0.286,0.296,0.565,0.62,0.339,0.233,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,339.0,3.45,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001354,70
p.Y220S,WM-TP53-05671,WM-TP53-05671,screening,-4.36,-3.22,0.38,0.045,0.38,0.332,0.355,0.577,0.18,0.482,0.23,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,248.0,2.49,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000633,71
p.Y220S,WM-TP53-03988,WM-TP53-03988,screening,-4.66,-3.7,0.32,0.083,0.32,0.343,0.353,0.555,0.18,0.463,0.228,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,256.1,2.15,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000381,72
p.Y220S,WM-TP53-01965,WM-TP53-01965,screening,-4.06,-3.2,0.287,0.007,0.287,0.297,0.313,0.727,0.18,0.268,0.228,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,311.1,3.09,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001051,73
p.Y220S,WM-TP53-06351,WM-TP53-06351,screening,-4.14,-3.2,0.313,0.017,0.313,0.307,0.325,0.643,0.18,0.282,0.227,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,294.4,2.57,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000918,74
p.Y220S,WM-TP53-06232,WM-TP53-06232,preclinical,-3.71,-3.2,0.17,0.0,0.17,0.276,0.278,0.759,0.4,0.226,0.227,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,281.9,1.65,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,75
p.Y220S,WM-TP53-00894,WM-TP53-00894,screening,-4.12,-3.2,0.307,0.015,0.307,0.304,0.322,0.676,0.18,0.322,0.226,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,381.2,3.92,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00095,76
p.Y220S,WM-TP53-01540,WM-TP53-01540,preclinical,-3.88,-3.2,0.227,0.0,0.227,0.284,0.294,0.698,0.4,0.315,0.226,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,320.1,3.08,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001424,77
p.Y220S,WM-TP53-00231,WM-TP53-00231,screening,-4.35,-3.2,0.383,0.044,0.383,0.332,0.355,0.557,0.18,0.521,0.225,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,294.1,3.13,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000644,78
p.Y220S,WM-TP53-01353,WM-TP53-01353,screening,-3.96,-3.2,0.253,0.0,0.253,0.288,0.301,0.775,0.18,0.264,0.224,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,300.0,2.29,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001244,79
p.Y220S,WM-TP53-01727,WM-TP53-01727,screening,-3.84,-3.2,0.213,0.0,0.213,0.282,0.29,0.812,0.18,0.209,0.223,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,247.7,2.06,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001524,80
p.Y220S,WM-TP53-01217,WM-TP53-01217,screening,-4.89,-4.03,0.287,0.111,0.287,0.354,0.356,0.509,0.18,0.491,0.222,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,181.1,1.91,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000259,81
p.Y220S,WM-TP53-05161,WM-TP53-05161,screening,-4.01,-3.2,0.27,0.001,0.27,0.291,0.306,0.721,0.18,0.273,0.221,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,318.3,3.17,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001144,82
p.Y220S,WM-TP53-01523,WM-TP53-01523,preclinical,-4.01,-3.2,0.27,0.001,0.27,0.291,0.306,0.598,0.4,0.377,0.22,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,364.7,4.85,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001144,83
p.Y220S,WM-TP53-02747,WM-TP53-02747,preclinical,-3.81,-3.2,0.203,0.0,0.203,0.28,0.287,0.651,0.4,0.256,0.219,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,232.3,2.16,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,84
p.Y220S,WM-TP53-03648,WM-TP53-03648,screening,-3.89,-3.2,0.23,0.0,0.23,0.284,0.294,0.758,0.18,0.233,0.218,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,282.1,2.51,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.0014,85
p.Y220S,WM-TP53-01982,WM-TP53-01982,screening,-3.79,-3.2,0.197,0.0,0.197,0.28,0.285,0.785,0.18,0.179,0.218,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,226.1,1.39,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001658,86
p.Y220S,WM-TP53-01472,WM-TP53-01472,screening,-4.3,-3.2,0.367,0.037,0.367,0.326,0.348,0.522,0.18,0.496,0.216,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,228.0,2.74,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000701,87
p.Y220S,WM-TP53-06572,WM-TP53-06572,screening,-3.9,-3.2,0.233,0.0,0.233,0.285,0.295,0.746,0.18,0.269,0.215,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,281.5,2.37,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001377,88
p.Y220S,WM-TP53-01064,WM-TP53-01064,screening,-3.82,-3.2,0.207,0.0,0.207,0.281,0.288,0.776,0.18,0.234,0.215,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,277.7,1.79,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001576,89
p.Y220S,WM-TP53-04073,WM-TP53-04073,screening,-4.0,-3.2,0.267,0.0,0.267,0.29,0.305,0.646,0.18,0.235,0.214,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,273.9,2.55,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001163,90
p.Y220S,WM-TP53-02526,WM-TP53-02526,screening,-4.79,-3.99,0.267,0.099,0.267,0.344,0.345,0.505,0.18,0.495,0.212,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,1.98,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000306,91
p.Y220S,WM-TP53-05586,WM-TP53-05586,screening,-4.16,-3.61,0.183,0.02,0.183,0.288,0.289,0.688,0.18,0.172,0.211,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,1.18,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000888,92
p.Y220S,WM-TP53-03529,WM-TP53-03529,approved,-3.58,-3.2,0.127,0.0,0.127,0.269,0.266,0.611,0.72,0.468,0.211,0.874,"C220,T150,P151,P222,V147,L145",Pass,False,True,297.2,2.25,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002364,93
p.Y220S,WM-TP53-05790,WM-TP53-05790,screening,-3.91,-3.2,0.237,0.0,0.237,0.286,0.296,0.694,0.18,0.273,0.209,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,333.7,2.43,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001354,94
p.Y220S,WM-TP53-04583,WM-TP53-04583,screening,-3.91,-3.2,0.237,0.0,0.237,0.286,0.296,0.657,0.18,0.238,0.208,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,265.7,1.87,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001354,95
p.Y220S,WM-TP53-02968,WM-TP53-02968,screening,-4.2,-3.2,0.333,0.025,0.333,0.314,0.334,0.646,0.18,0.647,0.206,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,357.3,4.55,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00083,96
p.Y220S,WM-TP53-03376,WM-TP53-03376,screening,-3.63,-3.2,0.143,0.0,0.143,0.271,0.27,0.791,0.18,0.174,0.206,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,230.4,1.24,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002173,97
p.Y220S,WM-TP53-00571,WM-TP53-00571,preclinical,-3.54,-3.2,0.113,0.0,0.113,0.267,0.262,0.736,0.4,0.272,0.206,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,360.3,3.14,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00253,98
p.Y220S,WM-TP53-03223,WM-TP53-03223,screening,-4.11,-3.2,0.303,0.014,0.303,0.303,0.32,0.597,0.18,0.464,0.203,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,244.4,2.16,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000966,99
p.Y220S,WM-TP53-04226,WM-TP53-04226,screening,-3.83,-3.2,0.21,0.0,0.21,0.281,0.289,0.696,0.18,0.291,0.201,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,347.3,3.44,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00155,100
p.Y220S,WM-TP53-01999,WM-TP53-01999,screening,-3.69,-3.2,0.163,0.0,0.163,0.274,0.276,0.764,0.18,0.286,0.199,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,327.7,2.62,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001963,101
p.Y220S,WM-TP53-05110,WM-TP53-05110,screening,-3.64,-3.2,0.147,0.0,0.147,0.272,0.271,0.77,0.18,0.246,0.199,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,326.1,2.74,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002136,102
p.Y220S,WM-TP53-05518,WM-TP53-05518,clinical,-3.68,-3.25,0.143,0.0,0.143,0.271,0.27,0.518,0.62,0.429,0.197,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,244.4,1.37,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,103
p.Y220S,WM-TP53-01557,WM-TP53-01557,preclinical,-3.42,-3.2,0.073,0.0,0.073,0.261,0.25,0.728,0.4,0.262,0.196,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,337.0,2.99,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,104
p.Y220S,WM-TP53-07677,WM-TP53-07677,screening,-3.59,-3.2,0.13,0.0,0.13,0.27,0.267,0.76,0.18,0.239,0.194,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,320.4,2.62,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002325,105
p.Y220S,WM-TP53-01897,WM-TP53-01897,screening,-3.44,-3.2,0.08,0.0,0.08,0.262,0.252,0.821,0.18,0.182,0.194,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,235.9,1.44,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002995,106
p.Y220S,WM-TP53-02883,WM-TP53-02883,screening,-3.62,-3.2,0.14,0.0,0.14,0.271,0.269,0.734,0.18,0.244,0.193,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,322.7,1.97,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00221,107
p.Y220S,WM-TP53-05195,WM-TP53-05195,screening,-3.75,-3.2,0.183,0.0,0.183,0.277,0.281,0.652,0.18,0.259,0.192,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,312.9,2.95,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001774,108
p.Y220S,WM-TP53-02458,WM-TP53-02458,screening,-3.71,-3.2,0.17,0.0,0.17,0.276,0.278,0.671,0.18,0.253,0.192,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,296.0,2.85,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001898,109
p.Y220S,WM-TP53-07048,WM-TP53-07048,screening,-4.31,-3.69,0.207,0.039,0.207,0.302,0.304,0.592,0.18,0.433,0.191,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,228.8,1.49,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000689,110
p.Y220S,WM-TP53-05433,WM-TP53-05433,screening,-4.1,-3.2,0.3,0.012,0.3,0.302,0.319,0.504,0.18,0.48,0.19,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,312.1,2.46,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000982,111
p.Y220S,WM-TP53-00299,WM-TP53-00299,screening,-4.09,-3.31,0.26,0.011,0.26,0.295,0.307,0.581,0.18,0.488,0.188,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,236.9,1.86,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000999,112
p.Y220S,WM-TP53-07711,WM-TP53-07711,screening,-4.03,-3.2,0.277,0.004,0.277,0.294,0.309,0.656,0.18,0.633,0.187,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,378.0,4.24,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001106,113
p.Y220S,WM-TP53-03733,WM-TP53-03733,screening,-3.49,-3.2,0.097,0.0,0.097,0.265,0.257,0.737,0.18,0.189,0.187,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,270.1,1.63,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002752,114
p.Y220S,WM-TP53-05569,WM-TP53-05569,screening,-4.05,-3.2,0.283,0.006,0.283,0.296,0.312,0.545,0.18,0.512,0.186,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,275.1,2.99,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001069,115
p.Y220S,WM-TP53-08136,WM-TP53-08136,screening,-3.59,-3.2,0.13,0.0,0.13,0.27,0.267,0.688,0.18,0.23,0.186,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,298.6,2.46,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002325,116
p.Y220S,WM-TP53-05246,WM-TP53-05246,preclinical,-3.99,-3.41,0.193,0.0,0.193,0.279,0.284,0.507,0.4,0.436,0.185,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,1.56,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,117
p.Y220S,WM-TP53-02611,WM-TP53-02611,screening,-3.57,-3.2,0.123,0.0,0.123,0.268,0.264,0.724,0.18,0.288,0.184,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,347.9,3.4,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002405,118
p.Y220S,WM-TP53-07490,WM-TP53-07490,screening,-3.61,-3.2,0.137,0.0,0.137,0.271,0.268,0.673,0.18,0.295,0.181,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,361.4,3.5,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002247,119
p.Y220S,WM-TP53-00826,WM-TP53-00826,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.696,0.4,0.189,0.181,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,340.8,1.63,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,unremarkable,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,120
p.Y220S,WM-TP53-06674,WM-TP53-06674,preclinical,-3.75,-3.2,0.183,0.0,0.183,0.277,0.281,0.517,0.4,0.477,0.18,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,298.4,2.4,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001774,121
p.Y220S,WM-TP53-07184,WM-TP53-07184,screening,-4.0,-3.2,0.267,0.0,0.267,0.29,0.305,0.53,0.18,0.496,0.179,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,302.2,2.73,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001163,122
p.Y220S,WM-TP53-01591,WM-TP53-01591,preclinical,-3.73,-3.2,0.177,0.0,0.177,0.277,0.28,0.536,0.4,0.506,0.179,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,299.9,2.9,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001835,123
p.Y220S,WM-TP53-00112,WM-TP53-00112,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.695,0.4,0.206,0.179,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,328.2,2.01,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,124
p.Y220S,WM-TP53-00265,WM-TP53-00265,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.694,0.4,0.203,0.179,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,329.1,1.95,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,125
p.Y220S,WM-TP53-03359,WM-TP53-03359,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.238,0.785,0.18,0.185,0.177,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,287.6,1.52,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,126
p.Y220S,WM-TP53-02152,WM-TP53-02152,screening,-3.39,-3.2,0.063,0.0,0.063,0.259,0.248,0.754,0.18,0.248,0.176,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,333.8,2.76,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003259,127
p.Y220S,WM-TP53-05008,WM-TP53-05008,screening,-3.94,-3.2,0.247,0.0,0.247,0.287,0.299,0.528,0.18,0.488,0.175,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,272.0,2.6,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001287,128
p.Y220S,WM-TP53-05229,WM-TP53-05229,screening,-3.57,-3.2,0.123,0.0,0.123,0.268,0.264,0.685,0.18,0.339,0.175,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,389.7,4.19,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002405,129
p.Y220S,WM-TP53-02679,WM-TP53-02679,screening,-4.01,-3.2,0.27,0.001,0.27,0.291,0.306,0.508,0.18,0.538,0.174,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,326.5,3.39,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001144,130
p.Y220S,WM-TP53-02407,WM-TP53-02407,screening,-3.97,-3.2,0.257,0.0,0.257,0.289,0.302,0.533,0.18,0.53,0.174,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,257.7,2.54,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001223,131
p.Y220S,WM-TP53-02169,WM-TP53-02169,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.245,0.744,0.18,0.235,0.174,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,336.7,2.55,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,132
p.Y220S,WM-TP53-05705,WM-TP53-05705,screening,-4.19,-3.72,0.157,0.024,0.157,0.287,0.284,0.601,0.18,0.452,0.173,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,206.4,1.19,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.000844,133
p.Y220S,WM-TP53-00503,WM-TP53-00503,screening,-3.44,-3.2,0.08,0.0,0.08,0.262,0.252,0.721,0.18,0.288,0.173,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,370.6,3.4,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002995,134
p.Y220S,WM-TP53-04311,WM-TP53-04311,screening,-3.37,-3.2,0.057,0.0,0.057,0.259,0.246,0.743,0.18,0.256,0.173,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,283.1,2.16,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003371,135
p.Y220S,WM-TP53-02917,WM-TP53-02917,screening,-3.83,-3.2,0.21,0.0,0.21,0.281,0.289,0.554,0.18,0.444,0.172,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,243.0,1.73,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00155,136
p.Y220S,WM-TP53-00928,WM-TP53-00928,screening,-3.65,-3.2,0.15,0.0,0.15,0.273,0.272,0.592,0.18,0.317,0.172,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,357.5,3.83,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002101,137
p.Y220S,WM-TP53-00435,WM-TP53-00435,screening,-3.25,-3.2,0.017,0.0,0.017,0.253,0.235,0.754,0.18,0.159,0.172,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,213.0,0.73,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004128,138
p.Y220S,WM-TP53-00452,WM-TP53-00452,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.797,0.18,0.171,0.172,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,307.8,1.16,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,139
p.Y220S,WM-TP53-00027,WM-TP53-00027,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.804,0.18,0.197,0.171,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,316.8,1.81,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,140
p.Y220S,WM-TP53-08391,WM-TP53-08391,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.234,0.771,0.18,0.202,0.17,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,280.1,1.92,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,141
p.Y220S,WM-TP53-05093,WM-TP53-05093,screening,-3.99,-3.35,0.213,0.0,0.213,0.282,0.29,0.523,0.18,0.447,0.169,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,215.5,1.82,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001183,142
p.Y220S,WM-TP53-05739,WM-TP53-05739,screening,-4.0,-3.46,0.18,0.0,0.18,0.277,0.28,0.575,0.18,0.434,0.168,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,222.6,1.5,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001163,143
p.Y220S,WM-TP53-04192,WM-TP53-04192,preclinical,-3.47,-3.2,0.09,0.0,0.09,0.264,0.255,0.577,0.4,0.454,0.167,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,256.8,1.96,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002847,144
p.Y220S,WM-TP53-03495,WM-TP53-03495,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.234,0.762,0.18,0.219,0.167,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,298.4,2.27,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,145
p.Y220S,WM-TP53-00095,WM-TP53-00095,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.756,0.18,0.168,0.167,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,336.2,1.06,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,146
p.Y220S,WM-TP53-04328,WM-TP53-04328,screening,-3.87,-3.2,0.223,0.0,0.223,0.283,0.292,0.528,0.18,0.515,0.166,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,319.6,3.04,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001449,147
p.Y220S,WM-TP53-01115,WM-TP53-01115,screening,-3.23,-3.2,0.01,0.0,0.01,0.252,0.233,0.75,0.18,0.221,0.165,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,329.1,2.3,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00427,148
p.Y220S,WM-TP53-00520,WM-TP53-00520,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.528,0.62,0.412,0.165,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,314.4,0.85,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,149
p.Y220S,WM-TP53-02390,WM-TP53-02390,screening,-3.97,-3.2,0.257,0.0,0.257,0.289,0.302,0.479,0.18,0.574,0.164,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,337.6,3.94,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001223,150
p.Y220S,WM-TP53-04566,WM-TP53-04566,screening,-3.68,-3.2,0.16,0.0,0.16,0.274,0.275,0.584,0.18,0.439,0.164,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,256.3,1.63,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001997,151
p.Y220S,WM-TP53-03750,WM-TP53-03750,preclinical,-3.81,-3.2,0.203,0.0,0.203,0.28,0.287,0.529,0.4,0.77,0.163,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,False,410.3,5.17,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001603,152
p.Y220S,WM-TP53-06215,WM-TP53-06215,screening,-3.52,-3.2,0.107,0.0,0.107,0.266,0.26,0.633,0.18,0.373,0.162,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,398.1,4.77,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002616,153
p.Y220S,WM-TP53-05722,WM-TP53-05722,screening,-3.43,-3.2,0.077,0.0,0.077,0.262,0.252,0.672,0.18,0.346,0.162,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,383.4,4.31,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003046,154
p.Y220S,WM-TP53-00163,WM-TP53-00163,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.721,0.18,0.178,0.162,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,312.3,1.34,Docking + MD (benchmark / cavity),Structural / cavity or core,Acceptable,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,low-external-evidence,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,155
p.Y220S,WM-TP53-01829,WM-TP53-01829,screening,-3.77,-3.2,0.19,0.0,0.19,0.278,0.283,0.553,0.18,0.524,0.161,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,304.8,3.18,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001715,156
p.Y220S,WM-TP53-04872,WM-TP53-04872,screening,-3.46,-3.2,0.087,0.0,0.087,0.263,0.254,0.647,0.18,0.351,0.161,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,387.9,4.38,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002896,157
p.Y220S,WM-TP53-00197,WM-TP53-00197,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.706,0.18,0.17,0.161,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,332.5,1.12,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,158
p.Y220S,WM-TP53-06402,WM-TP53-06402,screening,-3.88,-3.51,0.123,0.0,0.123,0.268,0.264,0.615,0.18,0.418,0.16,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,1.06,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.001424,159
p.Y220S,WM-TP53-00605,WM-TP53-00605,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.73,0.18,0.221,0.16,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,487.1,2.3,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,160
p.Y220S,WM-TP53-00843,WM-TP53-00843,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.734,0.18,0.227,0.16,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,332.2,2.41,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,161
p.Y220S,WM-TP53-05314,WM-TP53-05314,screening,-3.36,-3.2,0.053,0.0,0.053,0.258,0.245,0.62,0.18,0.232,0.159,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,297.3,2.49,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003428,162
p.Y220S,WM-TP53-03954,WM-TP53-03954,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.238,0.705,0.18,0.287,0.159,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,314.6,2.64,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,163
p.Y220S,WM-TP53-00622,WM-TP53-00622,clinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.494,0.62,0.45,0.157,0.854,"C220,T150,P151,P222,V147,L145",Pass,False,True,396.5,1.88,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,repurposing-eligible",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,164
p.Y220S,WM-TP53-00724,WM-TP53-00724,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.686,0.18,0.196,0.157,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,360.5,1.79,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,165
p.Y220S,WM-TP53-07116,WM-TP53-07116,screening,-3.62,-3.2,0.14,0.0,0.14,0.271,0.269,0.558,0.18,0.444,0.156,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,259.1,1.73,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00221,166
p.Y220S,WM-TP53-06164,WM-TP53-06164,screening,-3.57,-3.2,0.123,0.0,0.123,0.268,0.264,0.592,0.18,0.438,0.156,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,207.4,1.59,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002405,167
p.Y220S,WM-TP53-00248,WM-TP53-00248,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.716,0.18,0.249,0.156,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,370.7,2.78,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,168
p.Y220S,WM-TP53-03104,WM-TP53-03104,screening,-3.23,-3.2,0.01,0.0,0.01,0.252,0.233,0.728,0.18,0.318,0.155,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,385.7,3.86,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00427,169
p.Y220S,WM-TP53-00401,WM-TP53-00401,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.724,0.18,0.275,0.155,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,457.6,3.2,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,170
p.Y220S,WM-TP53-00554,WM-TP53-00554,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.69,0.18,0.223,0.155,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,316.5,2.34,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,171
p.Y220S,WM-TP53-00384,WM-TP53-00384,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.712,0.18,0.272,0.154,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,480.9,3.15,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,172
p.Y220S,WM-TP53-03512,WM-TP53-03512,preclinical,-3.42,-3.2,0.073,0.0,0.073,0.261,0.25,0.629,0.4,0.66,0.153,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,413.8,4.86,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,173
p.Y220S,WM-TP53-00775,WM-TP53-00775,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.709,0.18,0.289,0.152,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,385.0,2.68,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,174
p.Y220S,WM-TP53-07626,WM-TP53-07626,screening,-3.56,-3.2,0.12,0.0,0.12,0.268,0.264,0.556,0.18,0.438,0.151,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,301.5,1.61,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002445,175
p.Y220S,WM-TP53-00588,WM-TP53-00588,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.705,0.18,0.293,0.151,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,455.0,3.46,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,176
p.Y220S,WM-TP53-05025,WM-TP53-05025,screening,-3.23,-3.2,0.01,0.0,0.01,0.252,0.233,0.705,0.18,0.347,0.15,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,342.3,3.58,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00427,177
p.Y220S,WM-TP53-00316,WM-TP53-00316,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.706,0.18,0.31,0.15,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,409.8,2.99,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,178
p.Y220S,WM-TP53-00061,WM-TP53-00061,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.679,0.18,0.301,0.148,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,483.6,3.59,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,179
p.Y220S,WM-TP53-00656,WM-TP53-00656,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.686,0.18,0.307,0.148,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,462.6,3.68,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,180
p.Y220S,WM-TP53-07065,WM-TP53-07065,screening,-3.6,-3.2,0.133,0.0,0.133,0.27,0.267,0.626,0.18,0.634,0.147,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,389.4,4.25,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002286,181
p.Y220S,WM-TP53-04940,WM-TP53-04940,screening,-3.64,-3.2,0.147,0.0,0.147,0.272,0.271,0.542,0.18,0.559,0.146,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,301.9,2.98,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002136,182
p.Y220S,WM-TP53-00537,WM-TP53-00537,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.673,0.18,0.309,0.146,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,454.6,3.71,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,183
p.Y220S,WM-TP53-06113,WM-TP53-06113,screening,-3.62,-3.2,0.14,0.0,0.14,0.271,0.269,0.518,0.18,0.523,0.145,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,336.5,3.17,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.00221,184
p.Y220S,WM-TP53-00758,WM-TP53-00758,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.666,0.18,0.309,0.145,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,409.9,3.72,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,185
p.Y220S,WM-TP53-03937,WM-TP53-03937,screening,-3.39,-3.2,0.063,0.0,0.063,0.259,0.248,0.542,0.18,0.335,0.144,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,388.7,4.12,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003259,186
p.Y220S,WM-TP53-05076,WM-TP53-05076,screening,-3.45,-3.2,0.083,0.0,0.083,0.262,0.253,0.566,0.18,0.452,0.142,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,221.1,1.18,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002945,187
p.Y220S,WM-TP53-00486,WM-TP53-00486,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.662,0.18,0.343,0.142,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,441.0,4.25,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,188
p.Y220S,WM-TP53-02492,WM-TP53-02492,screening,-3.42,-3.2,0.073,0.0,0.073,0.261,0.25,0.546,0.18,0.419,0.14,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,192.4,1.08,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003098,189
p.Y220S,WM-TP53-00690,WM-TP53-00690,screening,-3.22,-3.2,0.007,0.0,0.007,0.251,0.232,0.601,0.18,0.324,0.138,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,373.3,3.22,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004343,190
p.Y220S,WM-TP53-00180,WM-TP53-00180,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.581,0.18,0.307,0.135,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,444.5,3.68,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,191
p.Y220S,WM-TP53-02730,WM-TP53-02730,screening,-3.3,-3.2,0.033,0.0,0.033,0.255,0.239,0.572,0.18,0.414,0.134,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,180.0,0.91,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003794,192
p.Y220S,WM-TP53-01948,WM-TP53-01948,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.238,0.608,0.18,0.459,0.134,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,279.7,1.33,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,193
p.Y220S,WM-TP53-00044,WM-TP53-00044,preclinical,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.506,0.4,0.489,0.134,0.81,"C220,T150,P151,P222,V147,L145",Pass,False,True,302.3,1.88,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,developability-risk,No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,194
p.Y220S,WM-TP53-06895,WM-TP53-06895,screening,-3.58,-3.41,0.057,0.0,0.057,0.259,0.246,0.521,0.18,0.435,0.132,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,230.4,0.81,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002364,195
p.Y220S,WM-TP53-04107,WM-TP53-04107,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.234,0.594,0.18,0.417,0.131,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,201.4,1.02,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,196
p.Y220S,WM-TP53-08340,WM-TP53-08340,screening,-3.21,-3.2,0.003,0.0,0.003,0.25,0.231,0.614,0.18,0.418,0.131,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,220.2,0.3,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004417,197
p.Y220S,WM-TP53-00639,WM-TP53-00639,screening,-3.32,-3.2,0.04,0.0,0.04,0.256,0.241,0.539,0.18,0.46,0.128,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,292.4,2.08,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003668,198
p.Y220S,WM-TP53-06453,WM-TP53-06453,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.234,0.563,0.18,0.419,0.127,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,243.9,1.09,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,199
p.Y220S,WM-TP53-06776,WM-TP53-06776,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.234,0.531,0.18,0.371,0.127,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,395.8,4.74,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,200
p.Y220S,WM-TP53-08170,WM-TP53-08170,screening,-3.26,-3.2,0.02,0.0,0.02,0.253,0.236,0.571,0.18,0.494,0.124,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,315.6,1.97,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004059,201
p.Y220S,WM-TP53-00010,WM-TP53-00010,screening,-3.52,-3.2,0.107,0.0,0.107,0.266,0.26,0.437,0.18,0.57,0.123,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,341.0,3.14,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.002616,202
p.Y220S,WM-TP53-07422,WM-TP53-07422,screening,-3.29,-3.2,0.03,0.0,0.03,0.255,0.238,0.637,0.18,0.633,0.123,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,430.3,4.98,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003859,203
p.Y220S,WM-TP53-00469,WM-TP53-00469,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.544,0.18,0.411,0.123,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,251.1,0.8,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,204
p.Y220S,WM-TP53-01013,WM-TP53-01013,screening,-3.35,-3.2,0.05,0.0,0.05,0.258,0.244,0.509,0.18,0.516,0.122,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,346.3,3.05,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003487,205
p.Y220S,WM-TP53-00129,WM-TP53-00129,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.556,0.18,0.437,0.122,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,337.7,0.84,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,206
p.Y220S,WM-TP53-01268,WM-TP53-01268,screening,-3.34,-3.2,0.047,0.0,0.047,0.257,0.243,0.517,0.18,0.529,0.121,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,319.4,3.26,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003546,207
p.Y220S,WM-TP53-06929,WM-TP53-06929,screening,-3.24,-3.2,0.013,0.0,0.013,0.252,0.234,0.53,0.18,0.453,0.121,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,272.3,1.93,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004199,208
p.Y220S,WM-TP53-03393,WM-TP53-03393,screening,-3.22,-3.2,0.007,0.0,0.007,0.251,0.232,0.532,0.18,0.473,0.118,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,317.3,2.34,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004343,209
p.Y220S,WM-TP53-00673,WM-TP53-00673,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.506,0.18,0.42,0.117,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,473.6,1.11,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,210
p.Y220S,WM-TP53-00418,WM-TP53-00418,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.53,0.18,0.474,0.116,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,440.0,2.35,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,211
p.Y220S,WM-TP53-00282,WM-TP53-00282,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.528,0.18,0.492,0.114,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,372.6,2.66,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,212
p.Y220S,WM-TP53-00350,WM-TP53-00350,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.467,0.18,0.409,0.114,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,517.7,3.71,Docking + MD (benchmark / cavity),Structural / cavity or core,Watch,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,213
p.Y220S,WM-TP53-07439,WM-TP53-07439,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.238,0.468,0.18,0.53,0.111,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,336.2,3.27,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,214
p.Y220S,WM-TP53-00078,WM-TP53-00078,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.482,0.18,0.469,0.111,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,388.2,1.52,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,215
p.Y220S,WM-TP53-07167,WM-TP53-07167,screening,-3.28,-3.2,0.027,0.0,0.027,0.254,0.238,0.454,0.18,0.624,0.101,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,386.6,4.06,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.003924,216
p.Y220S,WM-TP53-00809,WM-TP53-00809,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.469,0.18,0.58,0.1,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,418.1,3.31,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,217
p.Y220S,WM-TP53-00741,WM-TP53-00741,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.453,0.18,0.58,0.098,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,True,485.0,4.04,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,218
p.Y220S,WM-TP53-00792,WM-TP53-00792,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.537,0.18,0.736,0.096,0.766,"C220,T150,P151,P222,V147,L145",Pass,False,False,484.5,5.03,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,In-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,219
p.Y220S,WM-TP53-00333,WM-TP53-00333,screening,-3.2,-3.2,0.0,0.0,0.0,0.25,0.23,0.404,0.18,0.779,0.076,0.666,"C220,T150,P151,P222,V147,L145",Pass,False,False,477.1,6.2,Docking + MD (benchmark / cavity),Structural / cavity or core,Severe liability,Out-of-domain,Putative Y220C-cavity occupant (no published Kd); test as a mutant-selective stabilizer,rescue-score-v1.0,"developability-risk,low-external-evidence,out-of-domain",No-go,Do not advance; revisit pocket hypothesis or chemotype,0.004492,220