Update app.py

app.py

@@ -55,7 +55,11 @@ def chat(prompt, tools, voice_choice):
 
     if tools == "Yes":
         if (last_id != None):
-            response = client.responses.create(
+            response = client.responses.create
+                        instructions = 'You are a drug design assistant. Use tools provided for information; do not insert \
+                        your own knowledge if the information can be obtained from a tool. When calling a tool give complete \
+                        sentences for the task parameter. For example, do not define the task as "fetch smiles", rather, say: \
+                        "find the smiles string for the molecule".'
                         model = "o4-mini",
                         tools = cafchem_tools,
                         input=prompt,