{
  "medical_database": {
    "version": "1.0",
    "last_updated": "2026-01-21",
    "total_conditions": 15,
    "categories": [
      {
        "category_id": "CARDIO_001",
        "category_name": "Cardiovascular Diseases",
        "conditions": [
          {
            "condition_id": "CVD_001",
            "name": "Hypertension",
            "common_name": "High Blood Pressure",
            "severity": "moderate to severe",
            "prevalence": "31% of adults worldwide",
            "symptoms": [
              {
                "symptom": "Headaches",
                "frequency": "common",
                "severity": "mild to moderate"
              },
              {
                "symptom": "Shortness of breath",
                "frequency": "occasional",
                "severity": "moderate"
              },
              {
                "symptom": "Chest pain",
                "frequency": "rare",
                "severity": "severe"
              },
              {
                "symptom": "Visual changes",
                "frequency": "occasional",
                "severity": "moderate"
              }
            ],
            "risk_factors": [
              "Age over 60",
              "Family history",
              "Obesity (BMI > 30)",
              "High sodium intake (>2300mg/day)",
              "Sedentary lifestyle",
              "Excessive alcohol consumption"
            ],
            "diagnostic_tests": [
              {
                "test_name": "Blood pressure measurement",
                "normal_range": "120/80 mmHg",
                "hypertension_threshold": "140/90 mmHg"
              },
              {
                "test_name": "24-hour ambulatory monitoring",
                "purpose": "Confirm diagnosis and assess treatment"
              }
            ],
            "treatments": [
              {
                "type": "medication",
                "name": "ACE Inhibitors",
                "examples": ["Lisinopril", "Enalapril"],
                "mechanism": "Relax blood vessels"
              },
              {
                "type": "medication",
                "name": "Beta-blockers",
                "examples": ["Metoprolol", "Atenolol"],
                "mechanism": "Reduce heart rate and cardiac output"
              },
              {
                "type": "lifestyle",
                "interventions": [
                  "Reduce sodium to <1500mg/day",
                  "Exercise 150 minutes/week",
                  "Maintain healthy weight",
                  "Limit alcohol to 1-2 drinks/day"
                ]
              }
            ],
            "complications": [
              "Stroke",
              "Heart attack",
              "Kidney damage",
              "Vision loss",
              "Peripheral artery disease"
            ],
            "prognosis": "Good with proper management and medication adherence"
          },
          {
            "condition_id": "CVD_002",
            "name": "Coronary Artery Disease",
            "common_name": "CAD",
            "severity": "severe",
            "prevalence": "Leading cause of death globally",
            "symptoms": [
              {
                "symptom": "Angina (chest pain)",
                "frequency": "common",
                "severity": "moderate to severe",
                "characteristics": "Pressure, squeezing, or burning sensation"
              },
              {
                "symptom": "Shortness of breath",
                "frequency": "common",
                "severity": "moderate"
              },
              {
                "symptom": "Heart palpitations",
                "frequency": "occasional",
                "severity": "mild to moderate"
              }
            ],
            "risk_factors": [
              "High LDL cholesterol (>160 mg/dL)",
              "Smoking",
              "Diabetes mellitus",
              "Obesity",
              "Family history of early heart disease",
              "Chronic stress"
            ],
            "diagnostic_tests": [
              {
                "test_name": "Electrocardiogram (ECG)",
                "purpose": "Detect heart rhythm abnormalities"
              },
              {
                "test_name": "Coronary angiography",
                "purpose": "Visualize coronary artery blockages"
              },
              {
                "test_name": "Stress test",
                "purpose": "Assess heart function during exercise"
              },
              {
                "test_name": "Lipid panel",
                "normal_values": {
                  "total_cholesterol": "<200 mg/dL",
                  "LDL": "<100 mg/dL",
                  "HDL": ">40 mg/dL (men), >50 mg/dL (women)",
                  "triglycerides": "<150 mg/dL"
                }
              }
            ],
            "treatments": [
              {
                "type": "medication",
                "name": "Statins",
                "examples": ["Atorvastatin", "Rosuvastatin"],
                "purpose": "Lower cholesterol"
              },
              {
                "type": "procedure",
                "name": "Percutaneous Coronary Intervention (PCI)",
                "description": "Angioplasty with stent placement"
              },
              {
                "type": "surgery",
                "name": "Coronary Artery Bypass Grafting (CABG)",
                "indication": "Severe multi-vessel disease"
              }
            ],
            "emergency_signs": [
              "Severe chest pain lasting >5 minutes",
              "Pain radiating to arm, jaw, or back",
              "Shortness of breath with chest discomfort",
              "Nausea, cold sweat, lightheadedness"
            ]
          }
        ]
      },
      {
        "category_id": "RESP_001",
        "category_name": "Respiratory Diseases",
        "conditions": [
          {
            "condition_id": "RESP_001",
            "name": "Asthma",
            "severity": "mild to severe",
            "prevalence": "262 million people worldwide",
            "age_groups_affected": ["children", "adults", "elderly"],
            "symptoms": [
              {
                "symptom": "Wheezing",
                "frequency": "common",
                "timing": "Often worse at night or early morning"
              },
              {
                "symptom": "Shortness of breath",
                "frequency": "common",
                "severity": "variable"
              },
              {
                "symptom": "Chest tightness",
                "frequency": "common",
                "description": "Feeling of pressure or constriction"
              },
              {
                "symptom": "Coughing",
                "frequency": "very common",
                "timing": "Especially at night"
              }
            ],
            "triggers": [
              {
                "category": "Allergens",
                "examples": ["Pollen", "Dust mites", "Pet dander", "Mold"]
              },
              {
                "category": "Environmental",
                "examples": ["Cold air", "Air pollution", "Smoke", "Strong odors"]
              },
              {
                "category": "Physical",
                "examples": ["Exercise", "Respiratory infections"]
              },
              {
                "category": "Emotional",
                "examples": ["Stress", "Anxiety"]
              }
            ],
            "diagnostic_tests": [
              {
                "test_name": "Spirometry",
                "measures": "Lung function (FEV1, FVC)",
                "diagnostic_criteria": "FEV1/FVC ratio <70%"
              },
              {
                "test_name": "Peak flow meter",
                "purpose": "Monitor daily lung function at home"
              },
              {
                "test_name": "Allergy testing",
                "purpose": "Identify specific triggers"
              }
            ],
            "treatments": [
              {
                "type": "controller_medication",
                "name": "Inhaled Corticosteroids",
                "examples": ["Fluticasone", "Budesonide"],
                "frequency": "Daily",
                "purpose": "Reduce airway inflammation"
              },
              {
                "type": "rescue_medication",
                "name": "Short-acting Beta-agonists",
                "examples": ["Albuterol", "Salbutamol"],
                "frequency": "As needed",
                "purpose": "Quick relief of symptoms"
              },
              {
                "type": "combination_therapy",
                "name": "ICS/LABA",
                "examples": ["Fluticasone/Salmeterol"],
                "indication": "Moderate to severe asthma"
              }
            ],
            "asthma_action_plan": {
              "green_zone": {
                "description": "Doing well",
                "peak_flow": "80-100% of personal best",
                "action": "Continue regular medications"
              },
              "yellow_zone": {
                "description": "Caution",
                "peak_flow": "50-80% of personal best",
                "action": "Use rescue inhaler, may need to increase controller medication"
              },
              "red_zone": {
                "description": "Medical alert",
                "peak_flow": "<50% of personal best",
                "action": "Use rescue inhaler immediately and seek emergency care"
              }
            }
          },
          {
            "condition_id": "RESP_002",
            "name": "Chronic Obstructive Pulmonary Disease",
            "abbreviation": "COPD",
            "severity": "progressive, severe",
            "prevalence": "3rd leading cause of death worldwide",
            "subtypes": ["Chronic bronchitis", "Emphysema"],
            "symptoms": [
              {
                "symptom": "Chronic cough",
                "duration": "Present for at least 3 months in 2 consecutive years",
                "characteristics": "Productive cough with mucus"
              },
              {
                "symptom": "Shortness of breath",
                "progression": "Worsens over time",
                "severity": "Initially with exertion, later at rest"
              },
              {
                "symptom": "Wheezing",
                "frequency": "common"
              },
              {
                "symptom": "Chest tightness",
                "frequency": "common"
              }
            ],
            "risk_factors": [
              {
                "factor": "Smoking",
                "impact": "85-90% of COPD cases",
                "pack_years": "Risk increases with >20 pack-years"
              },
              {
                "factor": "Occupational exposures",
                "examples": ["Coal dust", "Silica", "Chemical fumes"]
              },
              {
                "factor": "Alpha-1 antitrypsin deficiency",
                "type": "Genetic",
                "prevalence": "Rare, 1-2% of COPD cases"
              }
            ],
            "GOLD_stages": [
              {
                "stage": "GOLD 1 (Mild)",
                "FEV1": "≥80% predicted",
                "symptoms": "Minimal"
              },
              {
                "stage": "GOLD 2 (Moderate)",
                "FEV1": "50-79% predicted",
                "symptoms": "Shortness of breath on exertion"
              },
              {
                "stage": "GOLD 3 (Severe)",
                "FEV1": "30-49% predicted",
                "symptoms": "Significant limitation"
              },
              {
                "stage": "GOLD 4 (Very Severe)",
                "FEV1": "<30% predicted",
                "symptoms": "Severe limitation, may need oxygen"
              }
            ],
            "treatments": [
              {
                "type": "bronchodilator",
                "name": "Long-acting Beta-agonists (LABA)",
                "examples": ["Formoterol", "Salmeterol"]
              },
              {
                "type": "bronchodilator",
                "name": "Long-acting Muscarinic Antagonists (LAMA)",
                "examples": ["Tiotropium", "Umeclidinium"]
              },
              {
                "type": "therapy",
                "name": "Pulmonary rehabilitation",
                "components": ["Exercise training", "Education", "Nutritional counseling"]
              },
              {
                "type": "oxygen_therapy",
                "indication": "Severe COPD with hypoxemia",
                "criteria": "PaO2 ≤55 mmHg or SpO2 ≤88%"
              }
            ],
            "prevention": {
              "primary": "Smoking cessation",
              "vaccinations": ["Influenza (annual)", "Pneumococcal", "COVID-19"]
            }
          }
        ]
      },
      {
        "category_id": "ENDO_001",
        "category_name": "Endocrine Disorders",
        "conditions": [
          {
            "condition_id": "ENDO_001",
            "name": "Type 2 Diabetes Mellitus",
            "severity": "chronic, progressive",
            "prevalence": "537 million adults worldwide",
            "pathophysiology": "Insulin resistance and relative insulin deficiency",
            "symptoms": [
              {
                "symptom": "Polyuria",
                "description": "Increased urination",
                "mechanism": "Glucose in urine draws water"
              },
              {
                "symptom": "Polydipsia",
                "description": "Increased thirst",
                "mechanism": "Dehydration from polyuria"
              },
              {
                "symptom": "Polyphagia",
                "description": "Increased hunger",
                "mechanism": "Cells unable to utilize glucose"
              },
              {
                "symptom": "Fatigue",
                "frequency": "very common"
              },
              {
                "symptom": "Blurred vision",
                "mechanism": "Glucose in lens causes swelling"
              }
            ],
            "diagnostic_criteria": [
              {
                "test": "Fasting Plasma Glucose",
                "normal": "<100 mg/dL",
                "prediabetes": "100-125 mg/dL",
                "diabetes": "≥126 mg/dL"
              },
              {
                "test": "HbA1c",
                "normal": "<5.7%",
                "prediabetes": "5.7-6.4%",
                "diabetes": "≥6.5%"
              },
              {
                "test": "Oral Glucose Tolerance Test (2-hour)",
                "normal": "<140 mg/dL",
                "prediabetes": "140-199 mg/dL",
                "diabetes": "≥200 mg/dL"
              }
            ],
            "treatment_targets": {
              "HbA1c": "<7% (individualized based on patient)",
              "fasting_glucose": "80-130 mg/dL",
              "postprandial_glucose": "<180 mg/dL",
              "blood_pressure": "<140/90 mmHg",
              "LDL_cholesterol": "<100 mg/dL"
            },
            "medications": [
              {
                "class": "Biguanides",
                "drug": "Metformin",
                "mechanism": "Reduces hepatic glucose production",
                "first_line": true
              },
              {
                "class": "GLP-1 Receptor Agonists",
                "examples": ["Semaglutide", "Liraglutide"],
                "benefits": ["Weight loss", "Cardiovascular protection"]
              },
              {
                "class": "SGLT2 Inhibitors",
                "examples": ["Empagliflozin", "Dapagliflozin"],
                "benefits": ["Weight loss", "Cardiovascular and renal protection"]
              },
              {
                "class": "Insulin",
                "types": ["Rapid-acting", "Long-acting", "Intermediate"],
                "indication": "Advanced disease or inadequate control"
              }
            ],
            "complications": {
              "microvascular": [
                {
                  "complication": "Diabetic retinopathy",
                  "screening": "Annual dilated eye exam"
                },
                {
                  "complication": "Diabetic nephropathy",
                  "screening": "Annual urine albumin and eGFR"
                },
                {
                  "complication": "Diabetic neuropathy",
                  "screening": "Annual foot exam"
                }
              ],
              "macrovascular": [
                "Coronary artery disease",
                "Stroke",
                "Peripheral artery disease"
              ]
            },
            "lifestyle_management": {
              "diet": "Mediterranean or DASH diet, carbohydrate counting",
              "exercise": "150 minutes/week moderate-intensity aerobic activity",
              "weight_loss": "5-10% body weight can significantly improve glycemic control",
              "monitoring": "Self-monitoring of blood glucose as recommended"
            }
          }
        ]
      }
    ],
    "emergency_protocols": {
      "chest_pain": {
        "action": "Call emergency services immediately",
        "first_aid": ["Have patient sit and rest", "Give aspirin if not allergic", "Loosen tight clothing"],
        "do_not": ["Give food or drink", "Leave patient alone"]
      },
      "severe_asthma_attack": {
        "action": "Use rescue inhaler, call emergency if no improvement in 5-10 minutes",
        "warning_signs": ["Difficulty speaking", "Blue lips or fingernails", "Severe shortness of breath"]
      },
      "hypoglycemia": {
        "blood_glucose": "<70 mg/dL",
        "symptoms": ["Shakiness", "Sweating", "Confusion", "Rapid heartbeat"],
        "treatment": "15g fast-acting carbohydrate (juice, glucose tablets), recheck in 15 minutes"
      }
    }
  }
}