"""SHAP-guided target site alignment visualization helpers."""

from __future__ import annotations

import io

import matplotlib.patches as patches
import matplotlib.pyplot as plt
import numpy as np
from PIL import Image


COLOR_PALETTE = [
    '#034da1', '#3359a7', '#4c66ad', '#6174b3', '#7482b9',
    '#8590be', '#979ec4', '#a8adca', '#b9bbcf', '#c9cbd5',
    '#dadada', '#dac4c4', '#daaeae', '#da9999', '#da8383',
    '#da6d6d', '#d95757', '#d94141', '#d92c2c', '#d91616', '#d90000',
]

COMPLEMENT = {
    'A': 'T',
    'T': 'A',
    'C': 'G',
    'G': 'C',
    '-': '',
    'N': '',
}


def _plot_t(ax, base, left_edge, height, color):
    ax.add_patch(patches.Rectangle(
        xy=[left_edge + 0.4, base], width=0.2, height=height,
        facecolor=color, edgecolor=color, fill=True
    ))
    ax.add_patch(patches.Rectangle(
        xy=[left_edge, base + 0.85 * height], width=1.0, height=0.15 * height,
        facecolor=color, edgecolor=color, fill=True
    ))


def _plot_g(ax, base, left_edge, height, color):
    ax.add_patch(patches.Ellipse(
        xy=[left_edge + 0.65, base + 0.5 * height], width=1.3, height=height,
        facecolor=color, edgecolor=color
    ))
    ax.add_patch(patches.Ellipse(
        xy=[left_edge + 0.65, base + 0.5 * height], width=0.91, height=0.7 * height,
        facecolor='white', edgecolor='white'
    ))
    ax.add_patch(patches.Rectangle(
        xy=[left_edge + 1, base], width=1.0, height=height,
        facecolor='white', edgecolor='white', fill=True
    ))
    ax.add_patch(patches.Rectangle(
        xy=[left_edge + 0.825, base + 0.085 * height], width=0.174, height=0.415 * height,
        facecolor=color, edgecolor=color, fill=True
    ))
    ax.add_patch(patches.Rectangle(
        xy=[left_edge + 0.625, base + 0.35 * height], width=0.374, height=0.15 * height,
        facecolor=color, edgecolor=color, fill=True
    ))


def _plot_a(ax, base, left_edge, height, color):
    polygons = [
        np.array([[0.0, 0.0], [0.5, 1.0], [0.5, 0.8], [0.2, 0.0]]),
        np.array([[1.0, 0.0], [0.5, 1.0], [0.5, 0.8], [0.8, 0.0]]),
        np.array([[0.225, 0.45], [0.775, 0.45], [0.85, 0.3], [0.15, 0.3]]),
    ]
    scale = np.array([1, height])[None, :]
    offset = np.array([left_edge, base])[None, :]
    for polygon in polygons:
        ax.add_patch(patches.Polygon(polygon * scale + offset, facecolor=color, edgecolor=color))


def _plot_c(ax, base, left_edge, height, color):
    ax.add_patch(patches.Ellipse(
        xy=[left_edge + 0.65, base + 0.5 * height], width=1.3, height=height,
        facecolor=color, edgecolor=color
    ))
    ax.add_patch(patches.Ellipse(
        xy=[left_edge + 0.65, base + 0.5 * height], width=0.91, height=0.7 * height,
        facecolor='white', edgecolor='white'
    ))
    ax.add_patch(patches.Rectangle(
        xy=[left_edge + 1, base], width=1.0, height=height,
        facecolor='white', edgecolor='white', fill=True
    ))


def _plot_n(ax, base, left_edge, height, color):
    ax.add_patch(patches.Rectangle(
        xy=[left_edge, base], width=0.2, height=height,
        facecolor=color, edgecolor=color, fill=True
    ))
    ax.add_patch(patches.Rectangle(
        xy=[left_edge + 0.8, base], width=0.15, height=height,
        facecolor=color, edgecolor=color, fill=True, angle=45
    ))
    ax.add_patch(patches.Rectangle(
        xy=[left_edge + 0.8, base], width=0.2, height=height,
        facecolor=color, edgecolor=color, fill=True
    ))


def _plot_dash(ax, base, left_edge, height, color):
    ax.add_patch(patches.Rectangle(
        xy=[left_edge + 0.2, base + 0.3 * height], width=0.6, height=0.2 * height,
        facecolor=color, edgecolor=color, fill=True
    ))


def _plot_line(ax, base, left_edge, height, color):
    ax.add_patch(patches.Rectangle(
        xy=[left_edge + 0.45, base + 0.2 * height], width=0.1, height=0.6 * height,
        facecolor=color, edgecolor=color, fill=True
    ))


def _plot_dot(ax, base, left_edge, height, color):
    ax.add_patch(patches.Ellipse(
        xy=[left_edge + 0.5, base + 0.5 * height], width=0.3, height=0.2 * height,
        facecolor=color, edgecolor=color
    ))


BASE_PLOTTERS = {
    'A': _plot_a,
    'C': _plot_c,
    'T': _plot_t,
    'G': _plot_g,
    'N': _plot_n,
    '-': _plot_dash,
}


class _ShapAlignment:
    """Needleman-Wunsch-style traceback with SHAP-informed scores."""

    RIGHT = "right"
    DOWN = "down"
    DIAGONAL = "diag"

    def align(self, mirna_seq, target_seq, score_matrix,
              opening_percentile=99, elongating_percentile=90):
        processed_scores, opening_gap, elongating_gap = self._preprocess_score(
            score_matrix, opening_percentile, elongating_percentile
        )
        grid = self._forward_pass(mirna_seq, target_seq, processed_scores, opening_gap, elongating_gap)
        return self._backward_pass(mirna_seq, target_seq, grid, processed_scores)

    def _score(self, grid, i, j, gap_penalty, score):
        directions = [self.RIGHT, self.DIAGONAL, self.DOWN]
        values = [
            grid[i, j - 1][1] - gap_penalty,
            grid[i - 1, j - 1][1] + score,
            grid[i - 1, j][1] - gap_penalty,
        ]
        best_index = int(np.argmax(values))
        return directions[best_index], values[best_index]

    def _forward_pass(self, mirna_seq, target_seq, score_matrix, opening_gap, elongating_gap):
        target_bases = [""] + list(target_seq)
        mirna_bases = [""] + list(mirna_seq)

        grid = np.empty((len(target_bases), len(mirna_bases)), dtype=object)
        for i in range(len(target_bases)):
            grid[i, 0] = (self.DOWN, 0.0)
        for j in range(len(mirna_bases)):
            grid[0, j] = (self.RIGHT, 0.0)

        is_opening = False
        for i in range(1, len(target_bases)):
            for j in range(1, len(mirna_bases)):
                gap_penalty = opening_gap if is_opening else elongating_gap
                if i == len(target_bases) - 1 or j == len(mirna_bases) - 1:
                    gap_penalty = 0.0
                grid[i, j] = self._score(grid, i, j, gap_penalty, score_matrix[i, j])
                is_opening = grid[i, j][0] == self.DIAGONAL

        return grid

    def _backward_pass(self, mirna_seq, target_seq, grid, score_matrix):
        target_bases = [""] + list(target_seq)
        mirna_bases = [""] + list(mirna_seq)

        aligned_target = []
        aligned_mirna = []
        aligned_scores = []

        i = grid.shape[0] - 1
        j = grid.shape[1] - 1
        while i != 0 or j != 0:
            direction = grid[i, j][0]
            if direction == self.RIGHT:
                aligned_target.append("-")
                aligned_mirna.append(mirna_bases[j])
                aligned_scores.append(0.0)
                j -= 1
            elif direction == self.DOWN:
                aligned_target.append(target_bases[i])
                aligned_mirna.append("-")
                aligned_scores.append(0.0)
                i -= 1
            else:
                aligned_target.append(target_bases[i])
                aligned_mirna.append(mirna_bases[j])
                aligned_scores.append(score_matrix[i, j])
                i -= 1
                j -= 1

        return aligned_target, aligned_scores, aligned_mirna

    def _preprocess_score(self, score_matrix, opening_percentile, elongating_percentile):
        score_matrix = np.asarray(score_matrix, dtype=float)
        if score_matrix.size == 0:
            return np.zeros((1, 1), dtype=float), 0.0, 0.0

        max_absolute_value = float(np.max(np.abs(score_matrix)))
        if max_absolute_value > 0:
            score_matrix = score_matrix / max_absolute_value
        else:
            score_matrix = np.zeros_like(score_matrix)

        abs_values = np.abs(score_matrix.sum(axis=-1)).ravel()
        opening_gap = float(np.nanpercentile(abs_values, opening_percentile)) if abs_values.size else 0.0
        elongating_gap = float(np.nanpercentile(abs_values, elongating_percentile)) if abs_values.size else 0.0

        score_matrix = np.vstack([np.zeros(score_matrix.shape[1]), score_matrix])
        score_matrix = np.hstack([np.zeros((score_matrix.shape[0], 1)), score_matrix])

        return score_matrix, opening_gap, elongating_gap


def _scale_scores(alignment_scores):
    values = np.asarray(alignment_scores, dtype=float)
    if values.size == 0:
        return np.array([], dtype=int)

    max_absolute_value = float(np.max(np.abs(values)))
    if max_absolute_value == 0.0:
        return np.full(values.shape, 10, dtype=int)

    scaled = values / max_absolute_value
    scaled = scaled * 10 + 10
    return np.clip(np.rint(scaled).astype(int), 0, len(COLOR_PALETTE) - 1)


def compute_shap_alignment(mirna_seq, target_seq, shap_2d,
                           opening_percentile=99, elongating_percentile=90):
    """Align miRNA and target using SHAP attributions as pairwise scores."""
    shap_array = np.asarray(shap_2d, dtype=float)
    expected_shape = (len(mirna_seq), len(target_seq))
    if shap_array.shape != expected_shape:
        raise ValueError(
            f"Expected shap_2d shape {expected_shape}, got {tuple(shap_array.shape)}"
        )

    aligner = _ShapAlignment()
    aligned_target, aligned_scores, aligned_mirna = aligner.align(
        mirna_seq[::-1],
        target_seq,
        shap_array[::-1].T,
        opening_percentile=opening_percentile,
        elongating_percentile=elongating_percentile,
    )
    return aligned_target[::-1], aligned_scores[::-1], aligned_mirna[::-1]


def plot_alignment_image(mirna_seq, target_seq, shap_2d, arrows=True):
    """Render the SHAP-guided alignment as a PIL image."""
    aligned_target, aligned_scores, aligned_mirna = compute_shap_alignment(
        mirna_seq, target_seq, shap_2d
    )
    color_indices = _scale_scores(aligned_scores)

    fig_width = max(12, len(aligned_target) * 0.42)
    fig, ax = plt.subplots(figsize=(fig_width, 3.2))

    step = 1.2
    left_margin = 2.8
    alignment_width = len(aligned_target) * step
    ax.set_xlim(-left_margin, alignment_width + 0.6)
    ax.set_ylim(0, 4.8)

    ax.text(-left_margin + 0.2, 3.5, "Target", ha='left', va='center',
            fontsize=12, fontweight='bold')
    ax.text(-left_margin + 0.2, 1.1, "miRNA", ha='left', va='center',
            fontsize=12, fontweight='bold')

    if arrows:
        ax.add_patch(patches.Arrow(x=0, y=4.4, dx=2, dy=0, width=0.6, color=COLOR_PALETTE[10]))
        ax.add_patch(patches.Arrow(
            x=max(alignment_width - 0.2, 0), y=0.2, dx=-2, dy=0, width=0.6, color=COLOR_PALETTE[10]
        ))

    ax.text(-0.1, 4.45, "5'", ha='right', va='center', fontsize=10, fontweight='bold')
    ax.text(alignment_width + 0.15, 4.45, "3'", ha='left', va='center', fontsize=10, fontweight='bold')
    ax.text(-0.1, 0.15, "3'", ha='right', va='center', fontsize=10, fontweight='bold')
    ax.text(alignment_width + 0.15, 0.15, "5'", ha='left', va='center', fontsize=10, fontweight='bold')

    for i, (target_base, mirna_base, color_index) in enumerate(
        zip(aligned_target, aligned_mirna, color_indices)
    ):
        color = COLOR_PALETTE[int(color_index)]
        left_edge = step * i

        BASE_PLOTTERS.get(mirna_base, _plot_n)(ax, 0.6, left_edge, 1.0, color)
        if mirna_base == COMPLEMENT.get(target_base):
            _plot_line(ax, 1.7, left_edge, 1.0, color)
        elif mirna_base in "ACTG" and target_base in "ACTG":
            _plot_dot(ax, 1.7, left_edge, 1.0, color)
        BASE_PLOTTERS.get(target_base, _plot_n)(ax, 3.0, left_edge, 1.0, color)

    ax.axis('off')
    fig.tight_layout()

    buffer = io.BytesIO()
    fig.savefig(buffer, format='png', dpi=120, bbox_inches='tight')
    buffer.seek(0)
    image = Image.open(buffer)
    plt.close(fig)
    return image