Update README.md

README.md

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 # Every Cure
 
-[Every Cure](https://everycure.org) is a nonprofit on a mission to save and improve lives by repurposing existing medicines. Our core research program is the **MATRIX** (ML/AI-enabled Therapeutic Repurposing In eXtended uses) platform — an AI-powered, open-source engine that systematically evaluates all FDA-approved drugs against all known diseases to surface the highest-impact repurposing opportunities.
-
-## What is MATRIX?
-
-MATRIX pioneers a field we call **computational pharmacophenomics**: a drug-agnostic, disease-agnostic approach that scores ~75 million drug–disease pairs using biomedical knowledge graphs, machine learning models, and real-world evidence. The platform integrates a human-in-the-loop medical review process, where our clinical team evaluates top-ranked predictions for biological plausibility, strategic fit, and clinical viability.
+[Every Cure](https://everycure.org) is a nonprofit on a mission to save and improve lives by repurposing existing medicines. We work across all drugs and all diseases to systematically identify the highest potential repurposing opportunities. 
 
 ## Datasets on HuggingFace
 
-Our current datasets include our 
-- Drug List: The Drugs against which we predict
-- Disease List: The Disease list against which we predict
-- KG Nodes & Edges: Our intermediate data artifact. We combine multiple upstream KGs and data sources to build an integrated KG. For a high level overview of the data, check our [data dashboard](https://data.dev.everycure.org/versions/latest/evidence)
-- MATRIX predictions: A dataset that contains a recent version of our predicted scores. A [global heatmap](https://prototypes.everycure.org/matrix-heatmap-public/) application allows top down exploration of these scores. 
+Our current datasets include: 
+- **Drug list:** the **drugs** we consider for repurposing opportunities
+- **Disease list:** the **diseases** we consider for repurposing opportunities
+- **KG Nodes & Edges:** One of the methods we use to predict repurposing opportunities is based on knowledge graphs. We combine multiple upstream KGs and data sources to build an integrated KG. For a high level overview of the data, check our [data dashboard](https://data.dev.everycure.org/versions/latest/evidence). The nodes and edges of our integarted graph are available for download below. 
+- **Predictions:** the latest scores for all drug-disease pairs from our KG-based method. These are updated approximately quarterly. A [heatmap application](https://prototypes.everycure.org/matrix-heatmap-public/) allows exploration of these scores. 
 
 ## Code & Documentation
 
@@ -31,7 +27,7 @@ Our current datasets include our
 | **Tech docs** | [docs.dev.everycure.org](https://docs.dev.everycure.org) |
 | **Disease list repo** | [everycure-org/matrix-disease-list](https://github.com/everycure-org/matrix-disease-list) |
 | **Drug list repo** | [everycure-org/matrix-drug-list](https://github.com/everycure-org/matrix-drug-list) |
-| **Indication list (ground truth)** | [everycure-org/matrix-indication-list](https://github.com/everycure-org/matrix-indication-list) |
+| **Indication list** | [everycure-org/matrix-indication-list](https://github.com/everycure-org/matrix-indication-list) |
 | **KG validator** | [everycure-org/matrix-validator](https://github.com/everycure-org/matrix-validator) |
 | **All repos** | [github.com/everycure-org](https://github.com/everycure-org) |
 
@@ -40,12 +36,11 @@ Our current datasets include our
 - **Lancet Haematology (2025)** — *Pioneering a new field of computational pharmacophenomics to unlock the life-saving potential of existing medicines.* Fajgenbaum DC et al. [everycure.org/lancet](https://everycure.org/lancet/)
 - **Platform paper (preprint, 2025)** — *Every Cure's End-to-End AI-Enabled Drug Repurposing Platform: Integrating Human-in-the-Loop Expertise to Accelerate Impact.* [DOI: 10.58647/REXPO.25000098.v1](https://drugrepocentral.scienceopen.com/hosted-document?doi=10.58647/REXPO.25000098.v1)
 - **MeDI (under submission)** — *MeDI: A Foundational Database to Support Drug Repurposing* — covers the MATRIX drug and disease list creation process.
+- **Unmet Medical Need Index** — *Unmet Medical Need Index: A Large Language Model-based methodology to Quantify Unmet Medical Need across the Disease Landscape* — covers the methodology behind our Unmet Medical Need assessments.
 
-## Program
+## Programs
 
 - [Active repurposing programs portfolio](https://everycure.org/portfolio/)
-- [ARPA-H Phase 1 announcement](https://everycure.org/every-cure-to-receive-48-3m-from-arpa-h-to-develop-ai-driven-platform-to-revolutionize-future-of-drug-development-and-repurposing/)
-- [ARPA-H award page](https://arpa-h.gov/news-and-events/arpa-h-awards-ai-driven-project-repurpose-approved-medications)
 
 ## Disclaimer
 The scores and predictions shared by Every Cure are the output of a computational research pipeline and are intended for research purposes only. They do not constitute medical advice, clinical recommendations, or endorsement of any drug for any use. Every Cure makes no warranties, express or implied, regarding the accuracy, completeness, or fitness for any particular purpose of the information presented. Drug repurposing opportunities identified here require rigorous independent scientific and clinical validation before any clinical application.