:root {
  --background: #f4f7f6;
  --surface: #ffffff;
  --surface-subtle: #f8faf9;
  --ink: #17211f;
  --muted: #61706c;
  --border: #d9e1de;
  --border-strong: #bcc9c5;
  --brand: #126f69;
  --brand-dark: #0d514d;
  --brand-soft: #e6f3f1;
  --green: #26724a;
  --green-soft: #e7f4ec;
  --red: #b5463e;
  --red-soft: #faece9;
  --amber: #8a661a;
  --amber-soft: #fbf3df;
  --focus: #16837c;
  --shadow: 0 10px 28px rgba(24, 48, 43, 0.08);
}

* {
  box-sizing: border-box;
}

html,
body {
  min-height: 100%;
}

body {
  margin: 0;
  background: var(--background);
  color: var(--ink);
  font-family:
    Inter, ui-sans-serif, system-ui, -apple-system, BlinkMacSystemFont, "Segoe UI", sans-serif;
}

button,
input,
textarea {
  font: inherit;
}

button {
  cursor: pointer;
}

button:disabled {
  cursor: not-allowed;
  opacity: 0.58;
}

h1,
h2,
h3,
p {
  margin-top: 0;
}

h1 {
  margin-bottom: 0;
  font-size: 3rem;
  line-height: 1.05;
  letter-spacing: 0;
}

h2 {
  margin-bottom: 0;
  font-size: 1.18rem;
  line-height: 1.3;
  letter-spacing: 0;
}

h3 {
  margin-bottom: 8px;
  font-size: 1rem;
  line-height: 1.35;
  letter-spacing: 0;
}

.appShell {
  width: min(1180px, calc(100% - 32px));
  margin: 0 auto;
  padding: 28px 0 36px;
}

.appHeader {
  max-width: 840px;
  margin-bottom: 24px;
  padding: 10px 0 6px;
}

.brandLine {
  display: flex;
  align-items: center;
  gap: 10px;
  margin-bottom: 18px;
}

.brandMark {
  display: inline-flex;
  width: 42px;
  height: 42px;
  align-items: center;
  justify-content: center;
  border-radius: 8px;
  background: var(--brand-dark);
  color: #ffffff;
}

.eyebrow,
.sectionEyebrow {
  margin: 0 0 5px;
  color: var(--brand-dark);
  font-size: 0.76rem;
  font-weight: 800;
  letter-spacing: 0;
  text-transform: uppercase;
}

.brandLine .eyebrow {
  margin-bottom: 0;
}

.subtitle {
  margin: 14px 0 0;
  color: #31423e;
  font-size: 1.25rem;
  font-weight: 700;
  line-height: 1.45;
}

.heroDescription {
  max-width: 680px;
  margin: 8px 0 0;
  color: var(--muted);
  font-size: 1rem;
  line-height: 1.6;
}

.statusPanel {
  display: flex;
  align-items: flex-start;
  gap: 11px;
  margin-bottom: 18px;
  border: 1px solid var(--border);
  border-radius: 8px;
  padding: 12px 14px;
  background: rgba(255, 255, 255, 0.7);
  color: var(--brand-dark);
}

.statusPanel div {
  display: grid;
  gap: 2px;
}

.statusPanel strong {
  font-size: 0.92rem;
}

.statusPanel span {
  color: var(--muted);
  font-size: 0.84rem;
  font-weight: 650;
}

.statusWarning {
  color: var(--red) !important;
}

.workspace {
  display: grid;
  grid-template-columns: minmax(0, 1fr) 320px;
  gap: 20px;
  align-items: start;
}

.mainColumn {
  display: grid;
  gap: 20px;
}

.toolPanel,
.resultPanel,
.historyPanel {
  border: 1px solid var(--border);
  border-radius: 8px;
  background: var(--surface);
  box-shadow: var(--shadow);
}

.toolPanel,
.resultPanel {
  padding: 24px;
}

.historyPanel {
  position: sticky;
  top: 20px;
  padding: 18px;
}

.panelHeader {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 14px;
  margin-bottom: 20px;
}

.buildPill,
.resultStatus {
  display: inline-flex;
  min-height: 28px;
  align-items: center;
  gap: 6px;
  border: 1px solid #9fc9c5;
  border-radius: 999px;
  padding: 4px 10px;
  background: var(--brand-soft);
  color: var(--brand-dark);
  font-size: 0.76rem;
  font-weight: 800;
  white-space: nowrap;
}

.formGrid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 14px;
}

label {
  display: grid;
  gap: 7px;
  color: #465652;
  font-size: 0.86rem;
  font-weight: 750;
}

input,
textarea {
  width: 100%;
  border: 1px solid var(--border-strong);
  border-radius: 8px;
  background: #ffffff;
  color: var(--ink);
  outline: none;
  transition:
    border-color 140ms ease,
    box-shadow 140ms ease;
}

input {
  min-height: 44px;
  padding: 0 12px;
}

textarea {
  min-height: 118px;
  resize: vertical;
  padding: 12px;
  font-family: "SFMono-Regular", Consolas, "Liberation Mono", monospace;
  line-height: 1.5;
}

input::placeholder,
textarea::placeholder {
  color: #899591;
}

input:focus,
textarea:focus {
  border-color: var(--focus);
  box-shadow: 0 0 0 3px rgba(22, 131, 124, 0.14);
}

.sequenceField {
  margin-top: 16px;
}

.notesField {
  margin-top: 14px;
}

.fieldHelp {
  display: flex;
  justify-content: space-between;
  gap: 12px;
  margin-top: 8px;
  color: var(--muted);
  font-size: 0.82rem;
  font-weight: 650;
}

.buttonRow {
  display: flex;
  flex-wrap: wrap;
  gap: 10px;
  margin-top: 20px;
}

.primaryButton,
.secondaryButton,
.iconButton {
  display: inline-flex;
  align-items: center;
  justify-content: center;
  border-radius: 8px;
  font-weight: 800;
  transition:
    background 140ms ease,
    border-color 140ms ease,
    color 140ms ease;
}

.primaryButton,
.secondaryButton {
  min-height: 44px;
  gap: 8px;
  padding: 0 17px;
}

.primaryButton {
  border: 1px solid var(--brand-dark);
  background: var(--brand);
  color: #ffffff;
}

.primaryButton:hover:not(:disabled) {
  background: var(--brand-dark);
}

.secondaryButton,
.iconButton {
  border: 1px solid var(--border);
  background: var(--surface-subtle);
  color: var(--ink);
}

.secondaryButton:hover:not(:disabled),
.iconButton:hover:not(:disabled) {
  border-color: var(--border-strong);
  background: #edf2f0;
}

.iconButton {
  width: 38px;
  height: 38px;
  padding: 0;
}

.resultPanel {
  min-height: 180px;
}

.statePanel,
.errorPanel {
  display: flex;
  align-items: center;
  gap: 14px;
}

.statePanel {
  color: var(--muted);
}

.statePanel h2,
.errorPanel h2 {
  margin-bottom: 4px;
}

.statePanel p,
.errorPanel p {
  margin-bottom: 0;
  line-height: 1.5;
}

.stateIcon {
  display: inline-flex;
  width: 46px;
  height: 46px;
  flex: 0 0 auto;
  align-items: center;
  justify-content: center;
  border-radius: 8px;
  background: var(--brand-soft);
  color: var(--brand-dark);
}

.loadingState .stateIcon {
  background: #eef3f2;
}

.errorPanel {
  border-color: rgba(181, 70, 62, 0.34);
  background: #fffafa;
  color: var(--red);
}

.errorPanel p {
  color: #75453f;
}

.resultComplete {
  border-top: 3px solid var(--brand);
}

.resultComplete.pathogenic {
  border-top-color: var(--red);
}

.resultComplete.benign {
  border-top-color: var(--green);
}

.resultHeader {
  margin-bottom: 16px;
}

.assessmentSummary {
  display: flex;
  align-items: flex-start;
  justify-content: space-between;
  gap: 20px;
  border-top: 1px solid var(--border);
  border-bottom: 1px solid var(--border);
  padding: 22px 0;
}

.assessmentLabel {
  display: block;
  margin-bottom: 7px;
  color: var(--muted);
  font-size: 0.78rem;
  font-weight: 800;
  text-transform: uppercase;
}

.assessmentSummary h3 {
  margin-bottom: 0;
  font-size: 1.35rem;
}

.assessmentContext {
  margin: 7px 0 0;
  color: var(--muted);
  font-size: 0.9rem;
  font-weight: 650;
}

.riskBadge {
  display: inline-flex;
  min-height: 34px;
  align-items: center;
  border-radius: 999px;
  padding: 7px 12px;
  font-size: 0.84rem;
  font-weight: 850;
  white-space: nowrap;
}

.riskBadge.pathogenic {
  background: var(--red-soft);
  color: var(--red);
}

.riskBadge.benign {
  background: var(--green-soft);
  color: var(--green);
}

.probabilityGrid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 22px;
  padding: 22px 0 4px;
}

.probabilityHeading {
  display: flex;
  align-items: baseline;
  justify-content: space-between;
  gap: 12px;
  margin-bottom: 9px;
  color: #455550;
  font-size: 0.88rem;
  font-weight: 750;
}

.probabilityHeading strong {
  color: var(--ink);
  font-size: 1.08rem;
}

.probabilityTrack {
  width: 100%;
  height: 9px;
  overflow: hidden;
  border-radius: 999px;
  background: #e6ecea;
}

.probabilityFill {
  height: 100%;
  border-radius: inherit;
}

.probabilityFill.pathogenic {
  background: var(--red);
}

.probabilityFill.benign {
  background: var(--green);
}

.confidenceSummary {
  display: flex;
  align-items: center;
  gap: 11px;
  margin-top: 20px;
  border-left: 3px solid var(--brand);
  padding: 8px 0 8px 13px;
  color: var(--brand-dark);
}

.confidenceSummary div {
  display: grid;
  gap: 2px;
}

.confidenceSummary span {
  color: var(--muted);
  font-size: 0.78rem;
  font-weight: 700;
}

.confidenceSummary strong {
  font-size: 0.94rem;
}

.interpretationSection {
  margin-top: 24px;
  border-top: 1px solid var(--border);
  padding-top: 22px;
}

.interpretationSection p,
.recommendationBlock p {
  margin-bottom: 0;
  color: #40504c;
  line-height: 1.65;
}

.recommendationBlock {
  display: flex;
  align-items: flex-start;
  gap: 12px;
  margin-top: 20px;
  border-left: 3px solid var(--amber);
  padding: 12px 0 12px 14px;
  color: var(--amber);
}

.recommendationBlock svg {
  flex: 0 0 auto;
  margin-top: 1px;
}

.recommendationBlock h3 {
  color: var(--ink);
}

.technicalDetails,
.noticeDetails {
  margin-top: 22px;
  border-top: 1px solid var(--border);
  padding-top: 14px;
}

.technicalDetails summary,
.noticeDetails summary {
  display: flex;
  align-items: center;
  justify-content: space-between;
  gap: 12px;
  cursor: pointer;
  color: #41514d;
  font-size: 0.9rem;
  font-weight: 800;
  list-style: none;
}

.technicalDetails summary::-webkit-details-marker,
.noticeDetails summary::-webkit-details-marker {
  display: none;
}

.technicalDetails summary span {
  display: inline-flex;
  align-items: center;
  gap: 8px;
}

.detailsChevron {
  transition: transform 160ms ease;
}

.technicalDetails[open] .detailsChevron {
  transform: rotate(180deg);
}

.technicalGrid {
  display: grid;
  grid-template-columns: repeat(2, minmax(0, 1fr));
  gap: 0 24px;
  margin: 16px 0 0;
  border-top: 1px solid var(--border);
}

.technicalGrid div {
  display: grid;
  grid-template-columns: minmax(120px, 0.8fr) minmax(0, 1.2fr);
  gap: 12px;
  border-bottom: 1px solid var(--border);
  padding: 11px 0;
}

dt {
  color: var(--muted);
  font-size: 0.76rem;
  font-weight: 800;
  text-transform: uppercase;
}

dd {
  margin: 0;
  overflow-wrap: anywhere;
  color: var(--ink);
  font-size: 0.86rem;
  font-weight: 750;
  text-align: right;
}

.emptyHistory {
  margin-bottom: 0;
  color: var(--muted);
  font-size: 0.9rem;
  line-height: 1.5;
}

.historyList {
  display: grid;
  gap: 9px;
}

.historyItem {
  display: grid;
  gap: 5px;
  width: 100%;
  min-height: 72px;
  border: 1px solid var(--border);
  border-radius: 8px;
  padding: 12px;
  background: #ffffff;
  color: var(--ink);
  text-align: left;
}

.historyItem:hover {
  border-color: #8ab7b2;
  background: var(--surface-subtle);
}

.historyItem.selected {
  border-color: var(--brand);
  box-shadow: 0 0 0 2px rgba(18, 111, 105, 0.12);
}

.historyVariant {
  overflow-wrap: anywhere;
  font-weight: 850;
}

.historyMeta {
  color: var(--muted);
  font-size: 0.81rem;
  font-weight: 700;
  text-transform: capitalize;
}

.historySequence {
  color: #74817d;
  font-family: "SFMono-Regular", Consolas, "Liberation Mono", monospace;
  font-size: 0.74rem;
  overflow-wrap: anywhere;
}

.appFooter {
  margin-top: 28px;
  border-top: 1px solid var(--border);
  padding: 20px 2px 0;
  color: var(--muted);
  font-size: 0.84rem;
  line-height: 1.55;
}

.appFooter > p {
  max-width: 920px;
  margin: 7px 0 0;
}

.noticeHeading {
  display: flex;
  align-items: center;
  gap: 8px;
  color: #465652;
}

.noticeDetails {
  max-width: 920px;
  margin-top: 12px;
  padding-top: 10px;
}

.noticeDetails ul {
  margin: 12px 0 0;
  padding-left: 20px;
}

.noticeDetails li + li {
  margin-top: 5px;
}

.spin {
  animation: spin 0.8s linear infinite;
}

@keyframes spin {
  from {
    transform: rotate(0deg);
  }
  to {
    transform: rotate(360deg);
  }
}

@media (max-width: 980px) {
  .workspace {
    grid-template-columns: 1fr;
  }

  .historyPanel {
    position: static;
  }
}

@media (max-width: 680px) {
  h1 {
    font-size: 2.3rem;
  }

  .subtitle {
    font-size: 1.08rem;
  }

  .appShell {
    width: min(100% - 20px, 1180px);
    padding: 18px 0 28px;
  }

  .toolPanel,
  .resultPanel,
  .historyPanel {
    padding: 17px;
  }

  .formGrid,
  .probabilityGrid,
  .technicalGrid {
    grid-template-columns: 1fr;
  }

  .assessmentSummary {
    align-items: flex-start;
    flex-direction: column;
    gap: 14px;
  }

  .technicalGrid div {
    grid-template-columns: 1fr;
    gap: 4px;
  }

  .technicalGrid dd {
    text-align: left;
  }

  .fieldHelp {
    display: grid;
  }

  .buttonRow {
    display: grid;
  }

  .primaryButton,
  .secondaryButton {
    width: 100%;
  }
}