antibiotic,model_breakpoint_used_for_S_NS,app_endpoint_tier,internal_n,internal_EA,internal_CA,public_n,public_EA,public_CA,local_n,local_EA,local_CA,app_interpretation
IPM,S <= 4 mg/L,Usable for MIC/high-resistance screening,12,0.6667,0.8333,5,0.4,0.4,82,0.9634146341463414,0.9634146341463414,"Strong local MIC-only performance and high agreement for high-MIC/non-susceptible isolates, but public external support is underpowered and susceptible isolates are scarce."
MEM,S <= 2 mg/L,Exploratory/supportive only,530,0.6547,0.9264,640,0.529690625,0.7906484375,70,0.7428571428571429,0.9428571428571428,High S/NS agreement in internal/local settings but weaker MIC agreement in public external validation; supportive only.
CAZ,S <= 8 mg/L,Exploratory/supportive only,530,0.8113,0.9075,566,0.7102512367491166,0.816286925795053,112,0.2142857142857142,0.2142857142857142,"Good internal and moderate public external performance, but poor local transferability; best treated as an exploratory endpoint."
FEP,S <= 8 mg/L,Supportive only,8,0.25,1.0,6,0.3333,0.3333,110,0.6090909090909091,0.8363636363636363,"Local S/NS performance is moderate, but internal/public sample sizes are too small; supportive only."
TZP,S <= 16 mg/L,Not recommended for standalone use,9,1.0,1.0,5,0.6,0.6,79,0.5569620253164557,0.569620253164557,Weak/unstable evidence across validations; not suitable for standalone use.
LVX,S <= 1 mg/L,Not recommended for standalone use,3,0.3333,1.0,353,0.2832509915014164,0.5807762039660057,103,0.4174757281553398,0.6116504854368932,Consistently weak MIC and S/NS performance; not suitable for standalone use.
AMK,S <= 8 mg/L,Recommended endpoint,530,0.866,0.9396,640,0.75623125,0.8593765624999999,113,0.8672566371681416,0.9026548672566372,"Most consistent endpoint across internal, public external and local MIC-only validation; suitable as the primary proof-of-concept endpoint."
TOB,S <= 4 mg/L,"Public-supported, local-calibration warning",530,0.8962,0.9642,521,0.8694898272552782,0.9289932821497122,113,0.0884955752212389,0.9203539823008848,"Strong internal and public external performance, but marked local MIC calibration failure; useful to illustrate domain shift and should be flagged in the app."