Upload 29 files
Browse files- Yeast_Processes_as_Programs.html +208 -12
- yeast_top_10_processes.html +358 -27
Yeast_Processes_as_Programs.html
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<meta charset="UTF-8">
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<meta name="viewport" content="width=device-width, initial-scale=1.0">
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<title>Yeast Processes as Programs: Evidence for the Genome-as-Computer-Program Thesis</title>
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<script src="https://cdn.jsdelivr.net/npm/mermaid/dist/mermaid.min.js">
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h1, h2, h3, p, li, a {
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font-family:
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}
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</style></head>
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<body>
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<div class="container">
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<meta charset="UTF-8">
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<meta name="viewport" content="width=device-width, initial-scale=1.0">
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<title>Yeast Processes as Programs: Evidence for the Genome-as-Computer-Program Thesis</title>
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<script src="https://cdn.jsdelivr.net/npm/mermaid@10.6.1/dist/mermaid.min.js"></script>
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<style>
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body {
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font-family: 'Georgia', 'Times New Roman', serif;
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line-height: 1.8;
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padding: 0;
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h1, h2, h3, p, li, a {
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font-family: 'Segoe UI', Tahoma, Geneva, Verdana, 'Arial Unicode MS', sans-serif;
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margin: 0 auto;
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box-shadow: 0 0 20px rgba(0,0,0,0.1);
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.header {
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background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
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color: white;
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padding: 3rem 2rem;
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text-align: center;
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.header h1 {
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margin: 0;
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font-size: 3rem;
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font-weight: 300;
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margin-bottom: 1rem;
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.header p {
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margin: 0;
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font-size: 1.4rem;
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opacity: 0.9;
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max-width: 800px;
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margin: 0 auto;
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}
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.content {
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padding: 3rem 2rem;
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}
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.intro {
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background: #e8f4fd;
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padding: 2rem;
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margin-bottom: 3rem;
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font-size: 1.1rem;
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.section {
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margin-bottom: 4rem;
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}
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.section h2 {
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color: #2c3e50;
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border-bottom: 3px solid #007bff;
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padding-bottom: 0.5rem;
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margin-bottom: 2rem;
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font-size: 2rem;
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}
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.process-showcase {
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margin: 3rem 0;
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padding: 2rem;
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border: 1px solid #dee2e6;
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border-radius: 12px;
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background: #fff;
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box-shadow: 0 4px 12px rgba(0,0,0,0.1);
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}
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.process-showcase.featured {
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border: 3px solid #28a745;
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background: linear-gradient(135deg, #f8fff9 0%, #e8f5e8 100%);
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}
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.process-showcase h3 {
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color: #495057;
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margin-top: 0;
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margin-bottom: 1rem;
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font-size: 1.5rem;
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}
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.process-showcase.featured h3 {
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color: #28a745;
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font-size: 1.7rem;
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}
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.process-description {
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background: #f8f9fa;
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padding: 1.5rem;
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border-radius: 8px;
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margin-bottom: 1.5rem;
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border-left: 4px solid #007bff;
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}
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.process-description h4 {
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color: #007bff;
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margin-top: 0;
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margin-bottom: 1rem;
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}
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.mermaid-container {
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background: white;
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padding: 1rem;
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border-radius: 8px;
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margin: 1rem 0;
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box-shadow: 0 2px 4px rgba(0,0,0,0.1);
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overflow-x: auto;
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}
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.mermaid {
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font-family: Arial, sans-serif !important;
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font-size: 14px !important;
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margin-top: 0;
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color: #495057;
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list-style: none;
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padding: 0;
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display: grid;
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grid-template-columns: repeat(auto-fit, minmax(250px, 1fr));
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gap: 0.5rem;
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padding: 0.5rem;
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background: #e8f5e8;
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padding: 2rem;
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border-radius: 8px;
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margin-top: 3rem;
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border-left: 5px solid #28a745;
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color: #28a745;
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margin-top: 0;
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background: #343a40;
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color: white;
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text-align: center;
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padding: 2rem;
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margin-top: 3rem;
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blockquote {
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border-left: 4px solid #007bff;
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padding-left: 1rem;
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margin: 2rem 0;
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font-style: italic;
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background: #f8f9fa;
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padding: 1rem;
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border-radius: 4px;
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font-size: 1.1rem;
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background: linear-gradient(135deg, #fff3cd 0%, #ffeaa7 100%);
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padding: 1.5rem;
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border-radius: 8px;
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border-left: 5px solid #ffc107;
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margin: 2rem 0;
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}
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.key-insight {
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background: #d1ecf1;
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padding: 1rem;
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border-radius: 6px;
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margin: 1rem 0;
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border-left: 4px solid #0dcaf0;
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.key-insight strong {
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color: #0c63e4;
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}
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</style></head>
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<body>
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<div class="container">
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yeast_top_10_processes.html
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<meta charset="UTF-8">
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<meta name="viewport" content="width=device-width, initial-scale=1.0">
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<title>Yeast Cellular Processes: Top 10 Foundational Processes</title>
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<script src="https://cdn.jsdelivr.net/npm/mermaid@10.6.1/dist/mermaid.min.js">
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}
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h1, h2, h3, p, li, a {
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font-family:
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</style></head>
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<body>
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<div class="container">
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@@ -96,19 +273,118 @@
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1. Glycolysis
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</h><div class="process-description">
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The central metabolic pathway that converts glucose to pyruvate, producing ATP and NADH. This process is essential for energy production and serves as the foundation for both aerobic and anaerobic metabolism.
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</div><div class="mermaid">
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2. TORC1 Nutrient Sensing
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</h><div class="process-description">
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The Target of Rapamycin Complex 1 (TORC1) pathway that integrates nutrient availability with cellular growth and metabolism. This pathway is central to cellular decision-making about growth versus survival.
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</div><div class="mermaid">
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</div>
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</div><!-- Stress Response
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-->
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@@ -123,11 +399,66 @@
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3. Heat Shock Response
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</h><div class="process-description">
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The cellular response to elevated temperatures, involving the activation of heat shock transcription factors and the synthesis of molecular chaperones to protect proteins from denaturation.
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</div><div class="mermaid">
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4. Autophagy Initiation
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</h><div class="process-description">
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The process of cellular self-digestion that is activated during nutrient limitation or stress conditions, allowing the cell to recycle cellular components for survival.
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| 4 |
<meta charset="UTF-8">
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| 5 |
<meta name="viewport" content="width=device-width, initial-scale=1.0">
|
| 6 |
<title>Yeast Cellular Processes: Top 10 Foundational Processes</title>
|
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+
<script src="https://cdn.jsdelivr.net/npm/mermaid@10.6.1/dist/mermaid.min.js"></script>
|
| 8 |
+
<style>
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| 9 |
+
body {
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| 10 |
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font-family: 'Segoe UI', Tahoma, Geneva, Verdana, sans-serif;
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| 11 |
+
line-height: 1.6;
|
| 12 |
+
margin: 0;
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| 13 |
+
padding: 20px;
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| 14 |
+
background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
|
| 15 |
+
color: #333;
|
| 16 |
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}
|
| 17 |
+
|
| 18 |
h1, h2, h3, p, li, a {
|
| 19 |
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font-family: 'Segoe UI', Tahoma, Geneva, Verdana, 'Arial Unicode MS', sans-serif;
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| 20 |
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}
|
| 21 |
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| 22 |
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.container {
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| 23 |
+
max-width: 1400px;
|
| 24 |
+
margin: 0 auto;
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| 25 |
+
background: white;
|
| 26 |
+
border-radius: 15px;
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| 27 |
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box-shadow: 0 20px 40px rgba(0,0,0,0.1);
|
| 28 |
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overflow: hidden;
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| 29 |
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}
|
| 30 |
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| 31 |
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.header {
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| 32 |
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background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
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| 33 |
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color: white;
|
| 34 |
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padding: 40px;
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| 35 |
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text-align: center;
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| 36 |
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}
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.header h1 {
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font-size: 2.5em;
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margin: 0;
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text-shadow: 2px 2px 4px rgba(0,0,0,0.3);
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}
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| 43 |
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.header p {
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font-size: 1.2em;
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margin: 10px 0 0 0;
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| 47 |
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opacity: 0.9;
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| 48 |
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}
|
| 49 |
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| 50 |
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.stats {
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| 51 |
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display: flex;
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| 52 |
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justify-content: space-around;
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| 53 |
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background: rgba(255,255,255,0.1);
|
| 54 |
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padding: 20px;
|
| 55 |
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margin: 20px 0;
|
| 56 |
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border-radius: 10px;
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| 57 |
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}
|
| 58 |
+
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| 59 |
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.stat {
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| 60 |
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text-align: center;
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}
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| 62 |
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| 63 |
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.stat-number {
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| 64 |
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font-size: 2em;
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| 65 |
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font-weight: bold;
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| 66 |
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display: block;
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| 67 |
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}
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| 68 |
+
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| 69 |
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.stat-label {
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| 70 |
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font-size: 0.9em;
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| 71 |
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opacity: 0.8;
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| 72 |
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}
|
| 73 |
+
|
| 74 |
+
.intro {
|
| 75 |
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background: #f8f9fa;
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| 76 |
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padding: 30px;
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| 77 |
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border-bottom: 1px solid #e9ecef;
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| 78 |
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}
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| 79 |
+
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| 80 |
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.intro h2 {
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| 81 |
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color: #495057;
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| 82 |
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margin-bottom: 20px;
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| 83 |
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font-size: 1.8em;
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| 84 |
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}
|
| 85 |
+
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| 86 |
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.intro p {
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color: #666;
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line-height: 1.6;
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| 89 |
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margin-bottom: 15px;
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| 90 |
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}
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| 91 |
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.content {
|
| 93 |
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padding: 40px;
|
| 94 |
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}
|
| 95 |
+
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| 96 |
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.process-section {
|
| 97 |
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margin-bottom: 60px;
|
| 98 |
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background: white;
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| 99 |
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border-radius: 15px;
|
| 100 |
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box-shadow: 0 10px 30px rgba(0,0,0,0.1);
|
| 101 |
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overflow: hidden;
|
| 102 |
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}
|
| 103 |
+
|
| 104 |
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.process-header {
|
| 105 |
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background: linear-gradient(135deg, #667eea 0%, #764ba2 100%);
|
| 106 |
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color: white;
|
| 107 |
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padding: 30px;
|
| 108 |
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text-align: center;
|
| 109 |
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}
|
| 110 |
+
|
| 111 |
+
.process-header h2 {
|
| 112 |
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margin: 0;
|
| 113 |
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font-size: 2em;
|
| 114 |
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text-shadow: 2px 2px 4px rgba(0,0,0,0.3);
|
| 115 |
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}
|
| 116 |
+
|
| 117 |
+
.process-header p {
|
| 118 |
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margin: 10px 0 0 0;
|
| 119 |
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opacity: 0.9;
|
| 120 |
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font-size: 1.1em;
|
| 121 |
+
}
|
| 122 |
+
|
| 123 |
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.process-content {
|
| 124 |
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padding: 30px;
|
| 125 |
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}
|
| 126 |
+
|
| 127 |
+
.process-description {
|
| 128 |
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color: #666;
|
| 129 |
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margin-bottom: 30px;
|
| 130 |
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line-height: 1.6;
|
| 131 |
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font-size: 1.1em;
|
| 132 |
+
}
|
| 133 |
+
|
| 134 |
+
.mermaid {
|
| 135 |
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background: white;
|
| 136 |
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border-radius: 8px;
|
| 137 |
+
padding: 20px;
|
| 138 |
+
margin: 20px 0;
|
| 139 |
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box-shadow: 0 3px 10px rgba(0,0,0,0.1);
|
| 140 |
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font-family: Arial, sans-serif !important;
|
| 141 |
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font-size: 14px !important;
|
| 142 |
+
}
|
| 143 |
+
|
| 144 |
+
.mermaid .node rect, .mermaid .node circle, .mermaid .node ellipse, .mermaid .node polygon {
|
| 145 |
+
stroke-width: 2px !important;
|
| 146 |
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}
|
| 147 |
+
|
| 148 |
+
.mermaid .label {
|
| 149 |
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font-family: Arial, sans-serif !important;
|
| 150 |
+
font-size: 14px !important;
|
| 151 |
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}
|
| 152 |
+
|
| 153 |
+
.color-legend {
|
| 154 |
+
background: #f8f9fa;
|
| 155 |
+
border-radius: 8px;
|
| 156 |
+
padding: 20px;
|
| 157 |
+
margin: 20px 0;
|
| 158 |
+
border-left: 4px solid #667eea;
|
| 159 |
+
}
|
| 160 |
+
|
| 161 |
+
.color-legend h4 {
|
| 162 |
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margin: 0 0 15px 0;
|
| 163 |
+
color: #495057;
|
| 164 |
+
}
|
| 165 |
+
|
| 166 |
+
.color-item {
|
| 167 |
+
display: flex;
|
| 168 |
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align-items: center;
|
| 169 |
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margin: 8px 0;
|
| 170 |
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}
|
| 171 |
+
|
| 172 |
+
.color-box {
|
| 173 |
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width: 20px;
|
| 174 |
+
height: 20px;
|
| 175 |
+
border-radius: 3px;
|
| 176 |
+
margin-right: 10px;
|
| 177 |
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}
|
| 178 |
+
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| 179 |
+
.footer {
|
| 180 |
+
background: #495057;
|
| 181 |
+
color: white;
|
| 182 |
+
text-align: center;
|
| 183 |
+
padding: 30px;
|
| 184 |
+
margin-top: 40px;
|
| 185 |
+
}
|
| 186 |
+
|
| 187 |
+
.footer p {
|
| 188 |
+
margin: 0;
|
| 189 |
+
opacity: 0.8;
|
| 190 |
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}
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| 191 |
+
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| 192 |
+
@media (max-width: 768px) {
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| 193 |
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.header h1 {
|
| 194 |
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font-size: 2em;
|
| 195 |
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}
|
| 196 |
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}
|
| 197 |
</style></head>
|
| 198 |
<body>
|
| 199 |
<div class="container">
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|
| 273 |
1. Glycolysis
|
| 274 |
</h><div class="process-description">
|
| 275 |
The central metabolic pathway that converts glucose to pyruvate, producing ATP and NADH. This process is essential for energy production and serves as the foundation for both aerobic and anaerobic metabolism.
|
| 276 |
+
</div> <div class="mermaid">
|
| 277 |
+
graph TD
|
| 278 |
+
%% Glycolysis Process
|
| 279 |
+
A[Glucose Input] --> B[Hexokinase]
|
| 280 |
+
B --> C[Glucose-6-Phosphate]
|
| 281 |
+
C --> D[Phosphoglucose Isomerase]
|
| 282 |
+
D --> E[Fructose-6-Phosphate]
|
| 283 |
+
E --> F[Phosphofructokinase]
|
| 284 |
+
F --> G[Fructose-1,6-Bisphosphate]
|
| 285 |
+
G --> H[Aldolase]
|
| 286 |
+
H --> I[Glyceraldehyde-3-Phosphate]
|
| 287 |
+
H --> J[Dihydroxyacetone Phosphate]
|
| 288 |
+
J --> K[Triose Phosphate Isomerase]
|
| 289 |
+
K --> I
|
| 290 |
+
I --> L[Glyceraldehyde-3-Phosphate Dehydrogenase]
|
| 291 |
+
L --> M[1,3-Bisphosphoglycerate]
|
| 292 |
+
M --> N[Phosphoglycerate Kinase]
|
| 293 |
+
N --> O[3-Phosphoglycerate]
|
| 294 |
+
O --> P[Phosphoglycerate Mutase]
|
| 295 |
+
P --> Q[2-Phosphoglycerate]
|
| 296 |
+
Q --> R[Enolase]
|
| 297 |
+
R --> S[Phosphoenolpyruvate]
|
| 298 |
+
S --> T[Pyruvate Kinase]
|
| 299 |
+
T --> U[Pyruvate Output]
|
| 300 |
+
|
| 301 |
+
%% Energy Production
|
| 302 |
+
N --> V[ATP Production]
|
| 303 |
+
L --> W[NADH Production]
|
| 304 |
+
|
| 305 |
+
%% Styling
|
| 306 |
+
style A fill:#ff6b6b,color:#fff
|
| 307 |
+
style U fill:#b197fc,color:#fff
|
| 308 |
+
style V fill:#b197fc,color:#fff
|
| 309 |
+
style W fill:#b197fc,color:#fff
|
| 310 |
+
|
| 311 |
+
style B fill:#ffd43b,color:#000
|
| 312 |
+
style D fill:#ffd43b,color:#000
|
| 313 |
+
style F fill:#ffd43b,color:#000
|
| 314 |
+
style H fill:#ffd43b,color:#000
|
| 315 |
+
style K fill:#ffd43b,color:#000
|
| 316 |
+
style L fill:#ffd43b,color:#000
|
| 317 |
+
style N fill:#ffd43b,color:#000
|
| 318 |
+
style P fill:#ffd43b,color:#000
|
| 319 |
+
style R fill:#ffd43b,color:#000
|
| 320 |
+
style T fill:#ffd43b,color:#000
|
| 321 |
+
|
| 322 |
+
style C fill:#74c0fc,color:#fff
|
| 323 |
+
style E fill:#74c0fc,color:#fff
|
| 324 |
+
style G fill:#74c0fc,color:#fff
|
| 325 |
+
style I fill:#74c0fc,color:#fff
|
| 326 |
+
style J fill:#74c0fc,color:#fff
|
| 327 |
+
style M fill:#74c0fc,color:#fff
|
| 328 |
+
style O fill:#74c0fc,color:#fff
|
| 329 |
+
style Q fill:#74c0fc,color:#fff
|
| 330 |
+
style S fill:#74c0fc,color:#fff<h3>
|
| 331 |
2. TORC1 Nutrient Sensing
|
| 332 |
</h><div class="process-description">
|
| 333 |
The Target of Rapamycin Complex 1 (TORC1) pathway that integrates nutrient availability with cellular growth and metabolism. This pathway is central to cellular decision-making about growth versus survival.
|
| 334 |
+
</div> <div class="mermaid">
|
| 335 |
+
graph TD
|
| 336 |
+
%% TORC1 Nutrient Sensing
|
| 337 |
+
A[Nutrient Availability] --> B[TORC1 Complex]
|
| 338 |
+
C[Amino Acids] --> B
|
| 339 |
+
D[Glucose] --> B
|
| 340 |
+
E[Oxygen] --> B
|
| 341 |
+
|
| 342 |
+
B --> F{High Nutrients?}
|
| 343 |
+
F -->|Yes| G[Activate TORC1]
|
| 344 |
+
F -->|No| H[Inhibit TORC1]
|
| 345 |
+
|
| 346 |
+
G --> I[Phosphorylate S6K]
|
| 347 |
+
G --> J[Phosphorylate 4E-BP]
|
| 348 |
+
I --> K[Activate Protein Synthesis]
|
| 349 |
+
J --> L[Release eIF4E]
|
| 350 |
+
L --> K
|
| 351 |
+
|
| 352 |
+
H --> M[Activate Autophagy]
|
| 353 |
+
H --> N[Inhibit Protein Synthesis]
|
| 354 |
+
|
| 355 |
+
%% Feedback loops
|
| 356 |
+
K --> O[Protein Levels]
|
| 357 |
+
O --> P{Protein Sufficient?}
|
| 358 |
+
P -->|Yes| Q[Reduce Synthesis]
|
| 359 |
+
P -->|No| R[Continue Synthesis]
|
| 360 |
+
|
| 361 |
+
M --> S[Autophagy Products]
|
| 362 |
+
S --> T[Nutrient Recycling]
|
| 363 |
+
T --> B
|
| 364 |
+
|
| 365 |
+
%% Styling
|
| 366 |
+
style A fill:#ff6b6b,color:#fff
|
| 367 |
+
style C fill:#ff6b6b,color:#fff
|
| 368 |
+
style D fill:#ff6b6b,color:#fff
|
| 369 |
+
style E fill:#ff6b6b,color:#fff
|
| 370 |
+
|
| 371 |
+
style B fill:#ffd43b,color:#000
|
| 372 |
+
style I fill:#ffd43b,color:#000
|
| 373 |
+
style J fill:#ffd43b,color:#000
|
| 374 |
+
style L fill:#ffd43b,color:#000
|
| 375 |
+
|
| 376 |
+
style F fill:#74c0fc,color:#fff
|
| 377 |
+
style G fill:#51cf66,color:#fff
|
| 378 |
+
style H fill:#51cf66,color:#fff
|
| 379 |
+
style K fill:#51cf66,color:#fff
|
| 380 |
+
style M fill:#51cf66,color:#fff
|
| 381 |
+
style N fill:#51cf66,color:#fff
|
| 382 |
+
style P fill:#74c0fc,color:#fff
|
| 383 |
+
style Q fill:#51cf66,color:#fff
|
| 384 |
+
style R fill:#51cf66,color:#fff
|
| 385 |
+
style S fill:#74c0fc,color:#fff
|
| 386 |
+
style T fill:#74c0fc,color:#fff
|
| 387 |
+
style O fill:#b197fc,color:#fff
|
| 388 |
</div>
|
| 389 |
</div><!-- Stress Response
|
| 390 |
-->
|
|
|
|
| 399 |
3. Heat Shock Response
|
| 400 |
</h><div class="process-description">
|
| 401 |
The cellular response to elevated temperatures, involving the activation of heat shock transcription factors and the synthesis of molecular chaperones to protect proteins from denaturation.
|
| 402 |
+
</div> <div class="mermaid">
|
| 403 |
+
graph TD
|
| 404 |
+
%% Heat Shock Response
|
| 405 |
+
A[Heat Stress] --> B[HSF1 Activation]
|
| 406 |
+
C[Protein Misfolding] --> A
|
| 407 |
+
|
| 408 |
+
B --> D[HSF1 Trimerization]
|
| 409 |
+
D --> E[HSF1 Phosphorylation]
|
| 410 |
+
E --> F[HSF1 Nuclear Localization]
|
| 411 |
+
F --> G[HSF1 Binding to HSE]
|
| 412 |
+
G --> H[HSP Gene Transcription]
|
| 413 |
+
H --> I[HSP Protein Synthesis]
|
| 414 |
+
I --> J[Protein Refolding]
|
| 415 |
+
J --> K[Cell Survival]
|
| 416 |
+
|
| 417 |
+
%% Additional regulatory mechanisms
|
| 418 |
+
L[HSF1 Inhibitors] --> B
|
| 419 |
+
M[HSP90] --> E
|
| 420 |
+
N[HSP70] --> J
|
| 421 |
+
O[HSP60] --> J
|
| 422 |
+
|
| 423 |
+
%% Feedback regulation
|
| 424 |
+
J --> P[Protein Quality]
|
| 425 |
+
P --> Q{Proteins Refolded?}
|
| 426 |
+
Q -->|Yes| R[Reduce HSP Synthesis]
|
| 427 |
+
Q -->|No| S[Continue HSP Synthesis]
|
| 428 |
+
|
| 429 |
+
%% Stress resolution
|
| 430 |
+
K --> T[Temperature Normalization]
|
| 431 |
+
T --> U[HSF1 Deactivation]
|
| 432 |
+
U --> V[Return to Normal State]
|
| 433 |
+
|
| 434 |
+
%% Styling
|
| 435 |
+
style A fill:#ff6b6b,color:#fff
|
| 436 |
+
style C fill:#ff6b6b,color:#fff
|
| 437 |
+
|
| 438 |
+
style B fill:#ffd43b,color:#000
|
| 439 |
+
style D fill:#ffd43b,color:#000
|
| 440 |
+
style E fill:#ffd43b,color:#000
|
| 441 |
+
style F fill:#ffd43b,color:#000
|
| 442 |
+
style G fill:#ffd43b,color:#000
|
| 443 |
+
style H fill:#ffd43b,color:#000
|
| 444 |
+
style I fill:#ffd43b,color:#000
|
| 445 |
+
style L fill:#ffd43b,color:#000
|
| 446 |
+
style M fill:#ffd43b,color:#000
|
| 447 |
+
style N fill:#ffd43b,color:#000
|
| 448 |
+
style O fill:#ffd43b,color:#000
|
| 449 |
+
|
| 450 |
+
style J fill:#51cf66,color:#fff
|
| 451 |
+
style K fill:#51cf66,color:#fff
|
| 452 |
+
style R fill:#51cf66,color:#fff
|
| 453 |
+
style S fill:#51cf66,color:#fff
|
| 454 |
+
style U fill:#51cf66,color:#fff
|
| 455 |
+
|
| 456 |
+
style P fill:#74c0fc,color:#fff
|
| 457 |
+
style Q fill:#74c0fc,color:#fff
|
| 458 |
+
style T fill:#74c0fc,color:#fff
|
| 459 |
+
style V fill:#74c0fc,color:#fff
|
| 460 |
+
|
| 461 |
+
style K fill:#b197fc,color:#fff<h3>
|
| 462 |
4. Autophagy Initiation
|
| 463 |
</h><div class="process-description">
|
| 464 |
The process of cellular self-digestion that is activated during nutrient limitation or stress conditions, allowing the cell to recycle cellular components for survival.
|