🦠Viral Entry & Replication Systems
Batch Overview: This batch contains 8 fundamental SARS-CoV-2 processes responsible for viral entry and replication. These processes represent the core computational systems that enable this coronavirus to infect host cells, replicate its genome, and produce viral proteins.
Each process demonstrates sophisticated biological programming with viral entry, RNA replication, protein synthesis, and immune response mechanisms.
📋 Table of Contents - 8 Viral Processes
1. Viral Entry
Detailed analysis of SARS-CoV-2 Viral Entry using the Programming Framework, revealing computational logic and regulatory patterns for host cell infection.
graph TD
%% Entry Triggers
A[ACE2 Binding] --> B[S Protein Activation]
C[TMPRSS2 Cleavage] --> D[Fusion Activation]
E[Endocytosis] --> F[Endosomal Entry]
G[Host Cell Contact] --> H[Entry Machinery]
%% ACE2 Binding
B --> I[S Protein-ACE2]
I --> J[Conformational Change]
J --> K[Receptor Binding]
%% Proteolytic Cleavage
D --> L[S Protein Cleavage]
L --> M[Fusion Peptide Exposure]
M --> N[Membrane Fusion]
%% Endosomal Entry
F --> O[Endosome Formation]
O --> P[Acidification]
P --> Q[Cathepsin Activation]
%% Integration
K --> R[Entry Program]
N --> R
Q --> R
H --> R
R --> S[Intracellular Localization]
%% Styling - Programming Framework Colors
style A fill:#ff6b6b,color:#fff
style C fill:#ff6b6b,color:#fff
style E fill:#ff6b6b,color:#fff
style G fill:#ff6b6b,color:#fff
style B fill:#ffd43b,color:#000
style D fill:#ffd43b,color:#000
style F fill:#ffd43b,color:#000
style H fill:#ffd43b,color:#000
style I fill:#ffd43b,color:#000
style J fill:#51cf66,color:#fff
style K fill:#51cf66,color:#fff
style L fill:#ffd43b,color:#000
style M fill:#51cf66,color:#fff
style N fill:#51cf66,color:#fff
style O fill:#ffd43b,color:#000
style P fill:#51cf66,color:#fff
style Q fill:#51cf66,color:#fff
style R fill:#74c0fc,color:#fff
style S fill:#b197fc,color:#fff
Triggers & Conditions
Catalysts & Enzymes
Chemical Processing
Intermediates
Products
2. Genome Release
Detailed analysis of SARS-CoV-2 Genome Release using the Programming Framework, revealing computational logic and regulatory patterns for viral RNA release.
graph TD
%% Release Components
A[Viral Particle] --> B[Capsid Disassembly]
C[Endosomal Acidification] --> D[Protease Activation]
E[Host Factors] --> F[RNA Release]
G[Intracellular Environment] --> H[Genome Processing]
%% Capsid Disassembly
B --> I[N Protein Release]
I --> J[RNA Uncoating]
J --> K[Genome Exposure]
%% Protease Activation
D --> L[Cathepsin L]
L --> M[Proteolytic Cleavage]
M --> N[Particle Disruption]
%% RNA Release
F --> O[Genome Release]
O --> P[Cytoplasmic Localization]
P --> Q[Translation Initiation]
%% Integration
K --> R[Release Program]
N --> R
Q --> R
H --> R
R --> S[Viral RNA Available]
%% Styling - Programming Framework Colors
style A fill:#ff6b6b,color:#fff
style C fill:#ff6b6b,color:#fff
style E fill:#ff6b6b,color:#fff
style G fill:#ff6b6b,color:#fff
style B fill:#ffd43b,color:#000
style D fill:#ffd43b,color:#000
style F fill:#ffd43b,color:#000
style H fill:#ffd43b,color:#000
style I fill:#ffd43b,color:#000
style J fill:#51cf66,color:#fff
style K fill:#51cf66,color:#fff
style L fill:#ffd43b,color:#000
style M fill:#51cf66,color:#fff
style N fill:#51cf66,color:#fff
style O fill:#ffd43b,color:#000
style P fill:#51cf66,color:#fff
style Q fill:#51cf66,color:#fff
style R fill:#74c0fc,color:#fff
style S fill:#b197fc,color:#fff
Triggers & Conditions
Catalysts & Enzymes
Chemical Processing
Intermediates
Products
3. Translation & Processing
Detailed analysis of SARS-CoV-2 Translation & Processing using the Programming Framework, revealing computational logic and regulatory patterns for viral protein synthesis.
graph TD
%% Translation Components
A[Viral RNA] --> B[Ribosome Binding]
C[Host Translation] --> D[Protein Synthesis]
E[Proteolytic Processing] --> F[Polyprotein Cleavage]
G[Host Proteases] --> H[Protein Processing]
%% Initial Translation
B --> I[ORF1a Translation]
I --> J[Polyprotein Synthesis]
J --> K[Proteolytic Processing]
%% Polyprotein Processing
D --> L[Main Protease]
L --> M[Nonstructural Proteins]
M --> N[Replication Complex]
%% Protein Processing
F --> O[Accessory Proteins]
O --> P[Structural Proteins]
P --> Q[Functional Proteins]
%% Integration
K --> R[Translation Program]
N --> R
Q --> R
H --> R
R --> S[Viral Proteins]
%% Styling - Programming Framework Colors
style A fill:#ff6b6b,color:#fff
style C fill:#ff6b6b,color:#fff
style E fill:#ff6b6b,color:#fff
style G fill:#ff6b6b,color:#fff
style B fill:#ffd43b,color:#000
style D fill:#ffd43b,color:#000
style F fill:#ffd43b,color:#000
style H fill:#ffd43b,color:#000
style I fill:#ffd43b,color:#000
style J fill:#51cf66,color:#fff
style K fill:#51cf66,color:#fff
style L fill:#ffd43b,color:#000
style M fill:#51cf66,color:#fff
style N fill:#51cf66,color:#fff
style O fill:#ffd43b,color:#000
style P fill:#51cf66,color:#fff
style Q fill:#51cf66,color:#fff
style R fill:#74c0fc,color:#fff
style S fill:#b197fc,color:#fff
Triggers & Conditions
Catalysts & Enzymes
Chemical Processing
Intermediates
Products
4. RNA Replication
Detailed analysis of SARS-CoV-2 RNA Replication using the Programming Framework, revealing computational logic and regulatory patterns for viral genome replication.
graph TD
%% Replication Components
A[Viral RNA] --> B[RdRp Complex]
C[Host Factors] --> D[Replication Machinery]
E[NTPs] --> F[RNA Synthesis]
G[Double-Membrane Vesicles] --> H[Replication Sites]
%% RdRp Assembly
B --> I[RdRp-Nsp12]
I --> J[Accessory Proteins]
J --> K[Replication Complex]
%% RNA Synthesis
D --> L[Minus Strand]
L --> M[Plus Strand]
M --> N[Genome Replication]
%% Replication Sites
F --> O[DMV Formation]
O --> P[Replication Compartments]
P --> Q[RNA Production]
%% Integration
K --> R[Replication Program]
N --> R
Q --> R
H --> R
R --> S[Viral Genomes]
%% Styling - Programming Framework Colors
style A fill:#ff6b6b,color:#fff
style C fill:#ff6b6b,color:#fff
style E fill:#ff6b6b,color:#fff
style G fill:#ff6b6b,color:#fff
style B fill:#ffd43b,color:#000
style D fill:#ffd43b,color:#000
style F fill:#ffd43b,color:#000
style H fill:#ffd43b,color:#000
style I fill:#ffd43b,color:#000
style J fill:#51cf66,color:#fff
style K fill:#51cf66,color:#fff
style L fill:#ffd43b,color:#000
style M fill:#51cf66,color:#fff
style N fill:#51cf66,color:#fff
style O fill:#ffd43b,color:#000
style P fill:#51cf66,color:#fff
style Q fill:#51cf66,color:#fff
style R fill:#74c0fc,color:#fff
style S fill:#b197fc,color:#fff
Triggers & Conditions
Catalysts & Enzymes
Chemical Processing
Intermediates
Products
5. Subgenomic Transcription
Detailed analysis of SARS-CoV-2 Subgenomic Transcription using the Programming Framework, revealing computational logic and regulatory patterns for viral gene expression.
graph TD
%% Transcription Components
A[Genome Template] --> B[Transcription Complex]
C[TRS Elements] --> D[Transcription Regulation]
E[Host Factors] --> F[RNA Polymerase]
G[Accessory Proteins] --> H[Transcription Control]
%% TRS Recognition
B --> I[TRS-Binding]
I --> J[Template Switching]
J --> K[Subgenomic RNA]
%% Transcription Regulation
D --> L[Nsp1 Inhibition]
L --> M[Host Translation Block]
M --> N[Viral RNA Synthesis]
%% RNA Processing
F --> O[5' Cap Addition]
O --> P[3' Polyadenylation]
P --> Q[Mature sgRNA]
%% Integration
K --> R[Transcription Program]
N --> R
Q --> R
H --> R
R --> S[Viral mRNAs]
%% Styling - Programming Framework Colors
style A fill:#ff6b6b,color:#fff
style C fill:#ff6b6b,color:#fff
style E fill:#ff6b6b,color:#fff
style G fill:#ff6b6b,color:#fff
style B fill:#ffd43b,color:#000
style D fill:#ffd43b,color:#000
style F fill:#ffd43b,color:#000
style H fill:#ffd43b,color:#000
style I fill:#ffd43b,color:#000
style J fill:#51cf66,color:#fff
style K fill:#51cf66,color:#fff
style L fill:#ffd43b,color:#000
style M fill:#51cf66,color:#fff
style N fill:#51cf66,color:#fff
style O fill:#ffd43b,color:#000
style P fill:#51cf66,color:#fff
style Q fill:#51cf66,color:#fff
style R fill:#74c0fc,color:#fff
style S fill:#b197fc,color:#fff
Triggers & Conditions
Catalysts & Enzymes
Chemical Processing
Intermediates
Products
6. Assembly & Budding
Detailed analysis of SARS-CoV-2 Assembly & Budding using the Programming Framework, revealing computational logic and regulatory patterns for viral particle formation.
graph TD
%% Assembly Components
A[Structural Proteins] --> B[Viral Assembly]
C[Viral RNA] --> D[Genome Packaging]
E[Host Factors] --> F[Assembly Machinery]
G[ER-Golgi] --> H[Assembly Sites]
%% Protein Assembly
B --> I[N Protein-RNA]
I --> J[Nucleocapsid Formation]
J --> K[Genome Encapsidation]
%% Structural Assembly
D --> L[M Protein Assembly]
L --> M[E Protein Integration]
M --> N[Viral Envelope]
%% Budding Process
F --> O[ER Budding]
O --> P[Golgi Processing]
P --> Q[Particle Release]
%% Integration
K --> R[Assembly Program]
N --> R
Q --> R
H --> R
R --> S[Mature Virion]
%% Styling - Programming Framework Colors
style A fill:#ff6b6b,color:#fff
style C fill:#ff6b6b,color:#fff
style E fill:#ff6b6b,color:#fff
style G fill:#ff6b6b,color:#fff
style B fill:#ffd43b,color:#000
style D fill:#ffd43b,color:#000
style F fill:#ffd43b,color:#000
style H fill:#ffd43b,color:#000
style I fill:#ffd43b,color:#000
style J fill:#51cf66,color:#fff
style K fill:#51cf66,color:#fff
style L fill:#ffd43b,color:#000
style M fill:#51cf66,color:#fff
style N fill:#51cf66,color:#fff
style O fill:#ffd43b,color:#000
style P fill:#51cf66,color:#fff
style Q fill:#51cf66,color:#fff
style R fill:#74c0fc,color:#fff
style S fill:#b197fc,color:#fff
Triggers & Conditions
Catalysts & Enzymes
Chemical Processing
Intermediates
Products
7. Immune Evasion
Detailed analysis of SARS-CoV-2 Immune Evasion using the Programming Framework, revealing computational logic and regulatory patterns for host immune system avoidance.
graph TD
%% Immune Detection
A[Host Immune Response] --> B[Interferon Inhibition]
C[Innate Immunity] --> D[Pattern Recognition]
E[Adaptive Immunity] --> F[Antigen Presentation]
G[Inflammatory Response] --> H[Immune Modulation]
%% Interferon Block
B --> I[Nsp1 Inhibition]
I --> J[Translation Block]
J --> K[Interferon Suppression]
%% Pattern Recognition
D --> L[TLR Inhibition]
L --> M[RIG-I Block]
M --> N[Innate Evasion]
%% Antigen Processing
F --> O[MHC Inhibition]
O --> P[Antigen Presentation Block]
P --> Q[Adaptive Evasion]
%% Integration
K --> R[Immune Evasion Program]
N --> R
Q --> R
H --> R
R --> S[Immune Escape]
%% Styling - Programming Framework Colors
style A fill:#ff6b6b,color:#fff
style C fill:#ff6b6b,color:#fff
style E fill:#ff6b6b,color:#fff
style G fill:#ff6b6b,color:#fff
style B fill:#ffd43b,color:#000
style D fill:#ffd43b,color:#000
style F fill:#ffd43b,color:#000
style H fill:#ffd43b,color:#000
style I fill:#ffd43b,color:#000
style J fill:#51cf66,color:#fff
style K fill:#51cf66,color:#fff
style L fill:#ffd43b,color:#000
style M fill:#51cf66,color:#fff
style N fill:#51cf66,color:#fff
style O fill:#ffd43b,color:#000
style P fill:#51cf66,color:#fff
style Q fill:#51cf66,color:#fff
style R fill:#74c0fc,color:#fff
style S fill:#b197fc,color:#fff
Triggers & Conditions
Catalysts & Enzymes
Chemical Processing
Intermediates
Products
8. Pathogenesis & Spread
Detailed analysis of SARS-CoV-2 Pathogenesis & Spread using the Programming Framework, revealing computational logic and regulatory patterns for disease development.
graph TD
%% Pathogenesis Components
A[Viral Replication] --> B[Cell Damage]
C[Inflammatory Response] --> D[Cytokine Storm]
E[Immune Dysregulation] --> F[Organ Damage]
G[Viral Spread] --> H[Transmission]
%% Cell Damage
B --> I[Apoptosis Induction]
I --> J[Cell Death]
J --> K[Tissue Damage]
%% Cytokine Storm
D --> L[Pro-inflammatory Cytokines]
L --> M[Immune Hyperactivation]
M --> N[Systemic Inflammation]
%% Organ Damage
F --> O[Lung Damage]
O --> P[Multi-organ Failure]
P --> Q[Severe Disease]
%% Integration
K --> R[Pathogenesis Program]
N --> R
Q --> R
H --> R
R --> S[Disease Progression]
%% Styling - Programming Framework Colors
style A fill:#ff6b6b,color:#fff
style C fill:#ff6b6b,color:#fff
style E fill:#ff6b6b,color:#fff
style G fill:#ff6b6b,color:#fff
style B fill:#ffd43b,color:#000
style D fill:#ffd43b,color:#000
style F fill:#ffd43b,color:#000
style H fill:#ffd43b,color:#000
style I fill:#ffd43b,color:#000
style J fill:#51cf66,color:#fff
style K fill:#51cf66,color:#fff
style L fill:#ffd43b,color:#000
style M fill:#51cf66,color:#fff
style N fill:#51cf66,color:#fff
style O fill:#ffd43b,color:#000
style P fill:#51cf66,color:#fff
style Q fill:#51cf66,color:#fff
style R fill:#74c0fc,color:#fff
style S fill:#b197fc,color:#fff
Triggers & Conditions
Catalysts & Enzymes
Chemical Processing
Intermediates
Products