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>cas__Q46896 Cas1 | cas | adaptation (universal) | Escherichia coli (strain K12)
MTWLPLNPIPLKDRVSMIFLQYGQIDVIDGAFVLIDKTGIRTHIPVGSVACIMLEPGTRVSHAAVRLAAQVGTLLVWVGE
AGVRVYASGQPGGARSDKLLYQAKLALDEDLRLKVVRKMFELRFGEPAPARRSVEQLRGIEGSRVRATYALLAKQYGVTW
NGRRYDPKDWEKGDTINQCISAATSCLYGVTEAAILAAGYAPAIGFVHTGKPLSFVYDIADIIKFDTVVPKAFEIARRNP
GEPDREVRLACRDIFRSSKTLAKLIPLIEDVLAAGEIQPPAPPEDAQPVAIPLPVSLGDAGHRSS
>cas__Q02ML7 Cas1 | cas | adaptation (universal) | Pseudomonas aeruginosa (strain UCBPP-PA14)
MDDISPSELKTILHSKRANLYYLQHCRVLVNGGRVEYVTDEGRHSHYWNIPIANTTSLLLGTGTSITQAAMRELARAGVL
VGFCGGGGTPLFSANEVDVEVSWLTPQSEYRPTEYLQRWVGFWFDEEKRLVAARHFQRARLERIRHSWLEDRVLRDAGFA
VDATALAVAVEDSARALEQAPNHEHLLTEEARLSKRLFKLAAQATRYGEFVRAKRGSGGDPANRFLDHGNYLAYGLAATA
TWVLGIPHGLAVLHGKTRRGGLVFDVADLIKDSLILPQAFLSAMRGDEEQDFRQACLDNLSRAQALDFMIDTLKDVAQRS
TVSA
>cas__G4RJY6 Cas1 | cas | adaptation (universal) | Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)
MDEVLLLTGGISITTRALRALLATGATVAVFSPRGEPLGIFMRPVGDATGAKRRCQYKAAEDGRGLQYAKSWVFKKILGQ
RDNIKAWRRRLRGYSQYAESLAKALPGAGLHGAMETPRRRRRGQDGGQAGVRGRPTHPPVPPGAGRRSPGGAPRGQEASL
RRDPQRGQSSGALHMYVIVVYDITENDVRAKVADILRAYGLARIQRSAYVGRLPPALVKELAERLARAVRGANADIAIFK
VDKRTIDTSLRIPPRPPAGHVALH
>cas__P9WPJ5 Cas1 | cas | adaptation (universal) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
MVQLYVSDSVSRISFADGRVIVWSEELGESQYPIETLDGITLFGRPTMTTPFIVEMLKRERDIQLFTTDGHYQGRISTPD
VSYAPRLRQQVHRTDDPAFCLSLSKRIVSRKILNQQALIRAHTSGQDVAESIRTMKHSLAWVDRSGSLAELNGFEGNAAK
AYFTALGHLVPQEFAFQGRSTRPPLDAFNSMVSLGYSLLYKNIIGAIERHSLNAYIGFLHQDSRGHATLASDLMEVWRAP
IIDDTVLRLIADGVVDTRAFSKNSDTGAVFATREATRSIARAFGNRIARTATYIKGDPHRYTFQYALDLQLQSLVRVIEA
GHPSRLVDIDITSEPSGA
>cas__O28401 Cas1 | cas | adaptation (universal) | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
MRLVVDGFGKYLGIENGLIVVKEKGKALRKVRPEDLKQVLIIGKAAISSDAIKLLLKNRVDVVFLDFNGEILGRLSHPLI
GTAKTRREQYLAYGDKRGVHLAKEFIKAKMANQMAILTNLAKARKDSNPEVAESLLKAKKEIDACLNELDGVEAEMIDKV
RERLLGIEGKASKHYWDAISLVIPEEYRFNGRRGIEIGSPRYAKDIVNAMLNYGYSILLAECVKAVELAGLDPYAGFLHV
DVSGRSSLAIDLMENFRQQVVDRVVLRLISYRQIKPEDCEKRNMVCQLSDNARRLLLASLLERLDSKTQYRGRNLAYSSI
ILLHARDVVAFLRGERRYEGFVQKW
>cas__Q74H36 Cas1 | cas | adaptation (universal) | Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
MAETDGSIPLIPVRMLNEHVYCPRLAYLMWVQGEFSHNEFTVDGVIRHRRVDAGGGVLPSETQEDSRIHARSVSLSSERL
GITAKIDLVEGEGAYVSPVDYKRGKRPHVAGGAYEPERVQLCAQGLLLREHGFASDGGALYFVASRERVPVAFDDELIGR
TLAAIDEMGRTALSGTMPPPLEDSPKCPRCSLVGICLPDEVRFLSHLSVEPRPIIPADGRGLPLYVQSPKAYVRKDGDCL
VIEEERVRVAEARLGETSQVALFGNATLTTAALHECLRREIPVTWLSYGGWFMGHTVSTGHRNVETRTYQYQRSFDPETC
LNLARRWIVAKIANCRTLLRRNWRGEGDEAKAPPGLLMSLQDDMRHAMRAPSLEVLLGIEGASAGRYFQHFSRMLRGGDG
EGMGFDFTTRNRRPPKDPVNALLSFAYAMLTREWTVALAAVGLDPYRGFYHQPRFGRPALALDMMEPFRPLIADSTVLMA
INNGEIRTGDFVRSAGGCNLTDSARKRFIAGFERRMEQEVTHPIFKYTISYRRLLEVQARLLTRYLSGEIPAYPNFVTR
>cas__Q97Y84 Cas1 | cas | adaptation (universal) | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
MISVRTLVISEYGAYVYVKKNMLVIKKGDKKVEISPSEVDEILITVSCSISTSALSLALTHGISVMFLNSRETPWGILLP
SIVTETVKTKKAQYEAIVVRKDNRYGEEIISSKIYNQSVHLKYWARVTGTKNDYKELLDKDEPAAARVYWQNISQLLPKD
IGFDGRDVDGTDQFNMALNYSYAILYNTIFKYLVIAGLDPYLGFIHKDRPGNESLVYDFSEMFKPYIDFLLVRALRSGFR
LKVKGGLIEENSRGDLAKLIRKGMEENVKEESDHNPKTLIQAIRAHAVKLASSIREGKEYRGFKLVM
>cas__Q1CW50 Cas1 | cas | adaptation (universal) | Myxococcus xanthus (strain DK1622)
MSVVVTRYRGGGPQYMNASSTSPKPVVGEPSIRTHALHALAYCERLFYLEEVEELRVADAAVFAGRRLHVQLQEEGEHVE
LELASEALGLHGRVDAVKTREGTLVVYEHKRGRHAPGGDAPEAWPSDRLQAGAYALLVEERFPGAPVECRVRYHQTDTTV
RFPLDAALRGAVVAAVARARLLRASRERPPVTQEERKCAKCSLAPVCLPEEERQVVGEERPRLFPEDDVRQVLHVATPGT
RVGRAAEELVVTPPEGEGAPSRQPGRMVSALIAHGAVQVSAQALAYCVENDIGVHWFTSGGRYLGGLGGGAGNVHRRLRQ
FEALRQASVCLGLARRLVAAKLEGQLRFLLRASRGDSESRQVLASAVRDLRALLPKCEEAPSLEVLLGLEGAGAARYFGA
LPYLQGEDVDTRLRFEGRNRRPPRDRFNAVLGFLFGLVHREVEAAIRAVGLDVAFGFYHQPRGTAGPLGLDVMELFRVPL
ADMPLVASVNRRAWDADADFEVTSEHVWLSKAGRAKAIELYERRKRETWKNNVLGYSLSYARLVELEVRLLEKEWTGKPG
LFATFRLR
>cas__Q8F1F5 Cas1 | cas | adaptation (universal) | Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601)
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHK
RGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKTIDRAKGLSTSTNRPP
VAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPI
QEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQ
LRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDP
FNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKV
WLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>cas__G3ECR2 Cas1 | cas | adaptation (universal) | Streptococcus thermophilus
MAGWRTVVVNIHSKLSYKNNHLIFRNSYKTEMIHLSEIDILLLETTDIVLTTMLVKRLVDENILVIFCDDKRLPTAFLTP
YYARHDSSLQIARQIAWKENVKCEVWTAIIAQKILNQSYYLGECSFFEKSQSIMELYHGLERFDPSNREGHSARIYFNTL
FGNDFTRESDNDINAALDYGYTLLLSMFAREVVVCGCMTQIGLKHANQFNQFNLASDIMEPFRPIIDRIVYQNRHNNFVK
IKKELFSIFSETYLYNGKEMYLSNIVSDYTKKVIKALNQLGEEIPEFRI
>cas__Q2FPW6 Cas1 | cas | adaptation (universal) | Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)
MGGFGAHIKSNRTEITIQHKGKITDIPIKDLSHFLLIGGHTIQTSTITSLVKEGVFISFCESDGEPVGYISPYDYSLFKE
IQNLQKTAAPYSYALACANESIKSRILAIEKYAEEIGPEILFSGELDILTGYAKELENMVLIEELRRIEQLVRDMYYEIL
GRLISPTYLFKRRTSRPYLDPVNAIFSFGYGMLSSACTRAVIGGHLDPGHGYLNRGNQALVQDLMNCWKPKMIDNHAIGF
LRSGRLHQNGYERTKDRCILHDEVIEELIHLFSKSIQEELINTQIDVLIQSLRGEAQFSIIKP
>cas__Q2RY11 Cas1 | cas | adaptation (universal) | Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)
MAPSDTPPSAEDLPSQGELALFAPPATAEDALVPASMVNAWIYCPRLAVLEWGRGEKARSVDLIAGLRAHQATESGPTPA
LPDPMVLREDQSLKTRRLSLSSERLGLTAELDLLDVEEGMVIPVEIKVGKRPSVDEGAYLPERAQVCAQALLLREAGYTC
LEGALWFAESRERVTVDLTEALVTATLVATSDLRLTVASGRLPPPLDHSAKCPRCSLLPICLPDEIAWFRKGSIARTPPP
PASPALPLYGQTPGARIGKKDYTLVIQVEGEADRSLALDEISEVVLAGPVSLTTPAIHELLRREIPVAWMSSGFWFLGST
GGQGPRSAAVRTAQYALAGDERRRQAFARDLVSAKIRNGRTLLRRNWRGAEAERQIALDRLARLAERATTAETTACLLGI
EGEAAAVYFRAFPQLFTQAVTTLPAFAFERRNRRPPADPVNACLSLCYAVLTRTLSSALSIAGLDPWKGFYHTERPGRPA
LALDLIESFRPVLADSTVLMVLNNGEIGTNDFLYAGGGCALKPNARRGLIAAYERRLDQETTHPVFGYQLSMRRLIQVQA
RLLARFVSGDIPRYPHYCPR
>cas__Q2RY21 Cas1 | cas | adaptation (universal) | Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)
MADPAFVPLRPIAIKDRSSIVFLQRGQLDVVDGAFVLIDQEGVRVQIPVGGLACLMLEPGTRITHAAIVLCARVGCLVIW
VGERGTRLYAAGQPGGARADRLLFQARNALDETARLNVVREMYRRRFDDDPPARRSVDQLRGMEGVRVREIYRLLAKKYA
VDWNARRYDHNDWDGADIPNRCLSAATACLYGLCEAAILAAGYAPAIGFLHRGKPQSFVYDVADLYKVETVVPTAFSIAA
KIAAGKGDDSPPERQVRIACRDQFRKSGLLEKIIPDIEEILRAGGLEPPLDAPEAVDPVIPPEEPSGDDGHRG
>cas__Q9X2B7 Cas1 | cas | adaptation (universal) | Thermotoga maritima (strain ATCC 43589 / DSM 3109 / JCM 10099 / NBRC 100826 / MSB8)
MESVYLFSSGTLKRKANTICLETESGRKYIPVENVMDIKVFGEVDLNKRFLEFLSQKRIPIHFFNREGYYVGTFYPREYL
NSGFLILKQAEHYINQEKRMLIAREIVSRSFQNMVDFLKKRKVRADSLTRYKKKAEEASNVSELMGIEGNAREEYYSMID
SLVSDERFRIEKRTRRPPKNFANTLISFGNSLLYTTVLSLIYQTHLDPRIGYLHETNFRRFSLNLDIAELFKPAVVDRLF
LNLVNTRQINEKHFDEISEGLMLNDEGKSLFVKNYEQALRETVFHKKLNRYVSMRSLIKMELHKLEKHLIGEQVFGSEE
>cas__A0Q5Y4 Cas1 | cas | adaptation (universal) | Francisella tularensis subsp. novicida (strain ATCC 15482 / CCUG 33449 / U112)
MKHLIISEYGIYLGLESGRLVVKNKDDKKYFPLNRLATLSIAKKGVSFSSDLVEQFSLRGIKLFFLDFRGVAHSMLVGAN
QHAVVQARINQYRYIDRNALTLSIKLIAAKIKNQRATLNYFNKHHKSINLLNAIEELKRVAQLIKNAKTLNDVLGYEGYA
ANIYFSSLAKDKFLSASFANREGRGSQEIANSMLNFGYAILSSYILNAITNAGLEPYLGFLHQKRPGKMSLVLDLMEEYR
AWVVDRVVIKLREQYKNKQYIDTKLKSILISEIQATIAKKYIYNGKKLKLEHIIQRQVYRLSGEFAGEHNYKPYIFKW
>cas__B5YJS2 Cas1 | cas | adaptation (universal) | Thermodesulfovibrio yellowstonii (strain ATCC 51303 / DSM 11347 / YP87)
MSTVFIDRKDIEIRVDGNSISFYAKGKKDGSLPLSPLKRVVIVGNVKIETSVLYKLVNHGITVLFLTGKLKYSGILNGPL
HNNGLLRVKQYQKSLSGFSLKFAKELIKRKIVSQRDFLSEIREIKKALAMQADRAIEILNKAISNIEVTPISIDSLRGIE
GAASSIYFITYSKIFPNSLKFVRRIKRPPKDPVNAMLSLCYTLLHYEIVREIQLIGLDPTIGFYHQFEYGRESLACDLVE
LFRVNVDRFVYELFKAKHLGNRDFMKDEESGGVYLKKTGRKKFYPLYEQWVQQQRTIWRGEVQGFARRILEEKDIISG
>cas__D4GQP0 Cas1 | cas | adaptation (universal) | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
MTKANHHIFADGELSRKEGTLRIDTLEGETKYLPVESIDALYLHGQISFNTRALGLLNKHGVPVHIFGWKDYYRGSYLPK
RSQLSGNTVVEQVRAYDNTERRLRIGHRIIEASIHNMRANLQYYSGRRGDFDSVVETLRELKTAVSDTQRIDELRAVEGD
ARKRYYDCFDSILEAPFRLAKREYNPPSNETNALISFLNGMVYTSCVSAIRKTALDPTVGFVHEPGERRFTLSLDIADIF
KPILADRLVFRLVNRKQITTDDFETELAGCLLTEQGRLTVLEEFERSLDQTVQHPRLKRKVSFKTLIQTDVYSLKKHLLT
GEPYHATEKWW
>cas__Q6D0X0 Cas1 | cas | adaptation (universal) | Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)
MDNAFSPSDLKTILHSKRANVYYLQHCRILVNGGRVEYVTEEGNQSLYWNIPIANTSVVMLGTGTSVTQAAMREFARAGV
MIGFCGGGGTPLFAANEAEVAVSWLSPQSEYRPTEYLQDWVSFWFDDEKRLAAAIAFQQVRITQIRQHWLGSRLSRESRF
TFKSEHLQALLDRYQKGLTDCRTSNDVLVQEAMMTKALYRLAANAVSYGDFTRAKRGGGTDLANRFLDHGNYLAYGLAAV
STWVLGLPHGLAVLHGKTRRGGLVFDVADLIKDALVLPQAFIAAMEGEDEQEFRQRCLTAFQQSEALDVMIGSLQDVASK
LSQVVR
>cas__Q74DC4 Cas1 | cas | adaptation (universal) | Geobacter sulfurreducens (strain ATCC 51573 / DSM 12127 / PCA)
MQPQLPPLKPIPIKDRISVLYVERGNLDVLDGAFVVVDKTGVRTHLPVGGVACLMLEPGTRVSHAAVTLASRIGCLLVWI
GEAGVRLYASGQPGGARADRLLYQAKLALDDSARLKVVRKMYALRFREEPPERRSVEQLRGIEGVRVRKMYELLARQHGV
AWKARNYDHTQWESGDVPNRCLSSATACLYGICEAAILAAGYAPAVGFIHTGKPQSFVYDIADIFKFETVVPVAFRIAAK
KPRDPEREVRLACRDAFRQSKILHRIIPTIEQVLAAGGMDVPTPPPESVEAVIPNKEGIGDAGHRG
>cas__B1L400 Cas1 | cas | adaptation (universal) | Korarchaeum cryptofilum (strain OPF8)
METTQYGHLLIDGFGVSLRKRRGRILILSKGEKKEIPMKSVKEVVIIGKAALSSELLKALAQSGTDLLIATPTGRPVARL
IPAKAGGTARNRYEQYKSLEDRRGIEIARAVIVGKIRNQASNLSYYSKARRMDEELSSELYDAAQQLKREMEELKNEEFP
DIDEARKRIMARESKCANIYWEKIASIMEEWKFRGREKRTDLEGNVIDPVNLCLNVCYNLLSAQIWKNVLRFGLDPFLGY
LHVERPGRISLVYDLMEPFRPMVDRFVFSYLRGMSPSLFSSNIVSGTIASLRSRFFSDFMNWRLDYKGRKLGMETIMFLY
VRDIVSFLRGGKEPTMPYIPW
>cas__P45956 Cas2 | cas | adaptation (universal) | Escherichia coli (strain K12)
MSMLVVVTENVPPRLRGRLAIWLLEVRAGVYVGDVSAKIREMIWEQIAGLAEEGNVVMAWATNTETGFEFQTFGLNRRTP
VDLDGLRLVSFLPV
>cas__Q9KFX8 Cas2 | cas | adaptation (universal) | Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)
MLVLITYDVQTSSMGGTKRLRKVAKACQNYGQRVQNSVFECIVDSTQLTSLKLELTSLIDEEKDSLRIYRLGNNYKTKVE
HIGAKPSIDLEDPLIF
>cas__Q97YC2 Cas2 | cas | adaptation (universal) | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
MAMLYLIFYDITDDNLRNRVAEFLKKKGLDRIQYSVFMGDLNSSRLKDVEAGLKIIGNRKKLQEDERFFILIVPITENQF
RERIVIGYSGSEREEKSNVVW
>cas__O05728 Cas2 | cas | adaptation (universal) | Helicobacter pylori (strain ATCC 700392 / 26695)
MYALAFDLKIEILKKEYGEPYNKAYDDLRQELELLGFEWTQGSVYVNYSKENTLAQVYKAINKLSQIEWFKKSVRDIRAF
KVEDFSDFTEIVKS
>cas__C9X1G7 Cas2 | cas | adaptation (universal) | Neisseria meningitidis serogroup C (strain 8013)
MSEAKFMRIIVFFDLPVITAAKRKAANQFRQFLLKDGYQMLQLSVYSRIVKGRDSLQKHHNRLCANLPQEGSIRCLEITE
KQYAAMKLLLGELKTQEKKVNSDQLLLF
>cas__O27155 Cas2 | cas | adaptation (universal) | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
MVVTVYLLIVYDVGVERVNRVKSYLRTELHWVQNSVFEGEVTESQFRRIETNLERIIDRERDSVIIYSFRSERAMNRNVL
GLEKSPLDVIL
>cas__O28403 Cas2 | cas | adaptation (universal) | Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)
MLHLVVYDISDDGSRARLAKLLEKFGLQRVQYSAFRGELNPNDREVLARQVGKFVRDDRDCIFIIPLCQRCSSTAIVISN
TGVELVKEKGVEFV
>cas__P9WPJ3 Cas2 | cas | adaptation (universal) | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
MPTRSREEYFNLPLKVDESSGTIGKMFVLVIYDISDNRRRASLAKILAGFGYRVQESAFEAMLTKGQLAKLVARIDRFAI
DCDNIRIYKIRGVAAVTFYGRGRLVSAEEFVFF
>cas__Q746F4 Cas2 | cas | adaptation (universal) | Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
MGKRLYAVAYDIPDDTRRVKLANLLKSYGERVQLSVFECYLDERLLEDLRRRARRLLDLGQDALRIYPVAGQVEVLGVGP
LPELREVQVL
>cas__Q82W51 Cas2 | cas | adaptation (universal) | Nitrosomonas europaea (strain ATCC 19718 / CIP 103999 / KCTC 2705 / NBRC 14298)
MLIIVTYDVSTETRAGRKRLRRVAKLCESIGQRVQKSVFECRINLMQYEELERRLLSEIDEQEDNLRLYRLTEPAELHVK
EYGNFKAIDFEGPLTI
>cas__Q97Y85 Cas2 | cas | adaptation (universal) | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
MKLLVVYDVSDDSKRNKLANNLKKLGLERIQRSAFEGDIDSQRVKDLVRVVKLIVDTNTDIVHIIPLGIRDWERRIVIGR
EGLEEWLV
>cas__D4GQP1 Cas2 | cas | adaptation (universal) | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
MQVIVVYDVPAKRTRIYRKLLRRRLEHLQYSVFFGELTAGQVTAMKNEIESELEPTDSIVVFEFDNPHAFDHTTFGDADE
PGSRFT
>cas__Q1CW51 Cas2 | cas | adaptation (universal) | Myxococcus xanthus (strain DK1622)
MAEPRRWYLITYDIRDPKRWRKVHALLKGYGEWLQLSVFRCSLTDRDREKLRWELSRRMDAVDTLLVIGLCGGCVERVRA
INAKEDWPEEPAPFKVL
>cas__A0Q5Y5 Cas2 | cas | adaptation (universal) | Francisella tularensis subsp. novicida (strain ATCC 15482 / CCUG 33449 / U112)
MQLRKEYLIAYDIEDNKTRTIIYKQLLAYGLKAVQKSVFWGYVSIAELNAIKRLFDSSLTISDKVFITRVNMHEQKLDYS
FGYDDKTFKDWDEYGHI
>cas__P38036 Cas3 | cas | Type I interference | Escherichia coli (strain K12)
MEPFKYICHYWGKSSKSLTKGNDIHLLIYHCLDVAAVADCWWDQSVVLQNTFCRNEMLSKQRVKAWLLFFIALHDIGKFD
IRFQYKSAESWLKLNPATPSLNGPSTQMCRKFNHGAAGLYWFNQDSLSEQSLGDFFSFFDAAPHPYESWFPWVEAVTGHH
GFILHSQDQDKSRWEMPASLASYAAQDKQAREEWISVLEALFLTPAGLSINDIPPDCSSLLAGFCSLADWLGSWTTTNTF
LFNEDAPSDINALRTYFQDRQQDASRVLELSGLVSNKRCYEGVHALLDNGYQPRQLQVLVDALPVAPGLTVIEAPTGSGK
TETALAYAWKLIDQQIADSVIFALPTQATANAMLTRMEASASHLFSSPNLILAHGNSRFNHLFQSIKSRAITEQGQEEAW
VQCCQWLSQSNKKVFLGQIGVCTIDQVLISVLPVKHRFIRGLGIGRSVLIVDEVHAYDTYMNGLLEAVLKAQADVGGSVI
LLSATLPMKQKQKLLDTYGLHTDPVENNSAYPLINWRGVNGAQRFDLLAHPEQLPPRFSIQPEPICLADMLPDLTMLERM
IAAANAGAQVCLICNLVDVAQVCYQRLKELNNTQVDIDLFHARFTLNDRREKENRVISNFGKNGKRNVGRILVATQVVEQ
SLDVDFDWLITQHCPADLLFQRLGRLHRHHRKYRPAGFEIPVATILLPDGEGYGRHEHIYSNVRVMWRTQQHIEELNGAS
LFFPDAYRQWLDSIYDDAEMDEPEWVGNGMDKFESAECEKRFKARKVLQWAEEYSLQDNDETILAVTRDGEMSLPLLPYV
QTSSGKQLLDGQVYEDLSHEQQYEALALNRVNVPFTWKRSFSEVVDEDGLLWLEGKQNLDGWVWQGNSIVITYTGDEGMT
RVIPANPK
>cas__F2XG53 Cas3 | cas | Type I interference | Streptococcus thermophilus
MKHINDYFWAKKTEENSRLLWLPLTQHLEDTKNIAGLLWEHWLSEGQKVLIENSINVKSNIENQGKRLAQFLGAVHDIGK
ATPAFQTQKGYANSVDLDIQLLEKLERAGFSGISSLQLASPKKSHHSIAGQYLLSHYGVDEDIATIIGGHHGRPVDDLDG
LNSQKSYPSNYYQDEKKDSLVYQKWKSNQEAFLNWALTETGFNSVSQLPKIKQPAQVILSGLLIMSDWIASNEHFFPLLS
LDETDVKNKSQRIETGFKKWKKSNLWQPETFVDLVTLYQERFGFSPRNFQLILSQTIEKTTNPGIVILEAPMGIGKTEAA
LAVSEQLSSKKGCSGLFFGLPTQATSNGIFKRIEQWTENIKGNNSDHFSIQLVHGKAALNTDFIELLKGNTINMDDSENG
SIFVNEWFSGRKTSALDDFVVGTVDQFLMVALKQKHLALRHLGFSKKVIVIDEVHAYDAYMSQYLLEAIRWMGAYGVPVI
ILSATLPAQQREKLIKSYMAGMGVKWRDIENIDQIKIDAYPLITYNDGPDIHQVKMFEKQEQKNIYIHRLPEEQLFDIVK
EGLDNGGVVGIIVNTVRKSQELARNFSDIFGDDMVDLLHSNFIATERIRKEKDLLQEIGKKAIRPPKKIIIGTQVLEQSL
DIDFDVLISDLAPMDLLIQRIGRLHRHKIKRPQKHEVARFYVLGTFEEFDFDEGTRLVYGDYLLARTQYFLPDKIRLPDD
ISPLVQKVYNSDLTITFPKPELHKKYLDAKIEHDDKIKNKETKAKSYRIANPVLKKSRVRTNSLIGWLKNLHPNDSEEKA
YAQVRDIEDTVEVIALKKISDGYGLFIENKDISQNITDPIIAKKVAQNTLRLPMSLSKAYNIDQTINELERYNNSHLSQW
QNSSWLKGSLGIIFDKNNEFILNGFKLLYDEKYGVTIERLDKNESV
>cas__Q53VY2 Cas3 | cas | Type I interference | Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
MSVEEAALALWAKSGNPFHPLLAHMLDTAAVALAVLRMEPPRTRALYAEDWGLPEEGALAWAAALVGLHDLGKASPVFQA
GWEEGKERVQRAGLPFGELLDWVAHGVFTELFLRRLLKEKGLPERAANDLAAALGAHHGFPANAEEKSRARRHLRTEDPL
WKEARRWLLEEVFRRLGAPLPPSQGNGEARPEAVLRVMALASFADWVASDPSLFPYGRDPRRGDYLKEALRLAQEALNRL
GWPAFAKAQRREFGELFPYIPKPNALQESVPALLEGACTPVLLLVEAPMGMGKTEAALYAHHLLQAGLGHRGLYVALPTQ
ATANGLFPRVRGFLERLGEGSRLELQLQHGTALLNPHYAGLLERAAPRQVGEEEEGGAVASAWFSARKRAMLAPYGVGTL
DQALLGVLRVKHHFVRLWGLMNRVVVLDEVHAYDVYTSGLLQALLRWLRALGSSAVVMTATLPPSRRRALLEAWAGEEVE
GQDLGPYPRVVLVGEGVKARSLPPAREVEVALEVLREVDVEPLAQRLKGALPGAVGAIVNTVDRAQDLYRALGEGTPLTL
EELARRLGGISGGQAWEEVRQALPERGGEVVGKVLTDGTLVFLLHARFPAEERALRGSVVLALFGKGGPRPPRAILVATQ
VAEQSLDLDFDLLYTDLAPIDLLFQRSGRLHRHERPRPEEHARPRLLLGVPEDLDFGKPLYWDKVYEDYVLLATWRALSG
RDRLRVPGDLEALLEEIYEGENPESFPEGLRERAKKSLKALQERRDREANTARRLSLSELDRLLAYWDEGALVAQERLED
DEEKAETQRLLTRLGDPSVAVVPLFRVGEGLFLDREGRRRAPLKGEVSREEAEALFRRAVRLSRFPLPQELLKEEPPPAW
RKSGLLRGLRPLEVGRVFRSGERAFQVELDPELGVVYLPV
>cas__Q57829 Cas3 | cas | Type I interference | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
MILGEIMEVLAFKNQSLIDHVNDMVKYWERIKYRYLKTIKRALEALNIKLDIEKVDEFMKILIKLHDIGKASKIYQRAII
NDQEKLMGFRHELVSAYYTYHILLKKFGDKNLAFIGALTVMLHHEPIIMGQIRNLKKKELTAEVVLDKLKKFDGMIEDFE
DLIKKLIGYSIGDIIKNDSNKDDIIRFVIEMSVRARHTPNSEKLRFIVGTLLLPLVMCDYKGAESREGKAPKFAEVLEVE
SYVI
>cas__Q02ML8 Cas3 | cas | Type I interference | Pseudomonas aeruginosa (strain UCBPP-PA14)
MNILLVSQCEKRALSETRRILDQFAERRGERTWQTPITQAGLDTLRRLLKKSARRNTAVACHWIRGRDHSELLWIVGDAS
RFNAQGAVPTNRTCRDILRKEDENDWHSAEDIRLLTVMAALFHDIGKASQAFQAKLRNRGKPMADAYRHEWVSLRLFEAF
VGPGSSDEDWLRRLADKRETGDAWLSQLARDDRQSAPPGPFQKSRLPPLAQAVGWLIVSHHRLPNGDHRGSASLARLPAP
IQSQWCGARDADAKEKAACWQFPHGLPFASAHWRARTALCAQSMLERPGLLARGPALLHDSYVMHVSRLILMLADHHYSS
LPADSRLGDPNFPLHANTDRDSGKLKQRLDEHLLGVALHSRKLAGTLPRLERQLPRLARHKGFTRRVEQPRFRWQDKAYD
CAMACREQAMEHGFFGLNLASTGCGKTLANGRILYALADPQRGARFSIALGLRSLTLQTGQAYRERLGLGDDDLAILVGG
SAARELFEKQQERLERSGSESAQELLAENSHVHFAGTLEDGPLREWLGRNSAGNRLLQAPILACTIDHLMPASESLRGGH
QIAPLLRLMTSDLVLDEVDDFDIDDLPALSRLVHWAGLFGSRVLLSSATLPPALVQGLFEAYRSGREIFQRHRGAPGRAT
EIRCAWFDEFSSQSSAHGAVTSFSEAHATFVAQRLAKLEQLPPRRQAQLCTVHAAGEARPALCRELAGQMNTWMADLHRC
HHTEHQGRRISFGLLRLANIEPLIELAQAILAQGAPEGLHVHLCVYHSRHPLLVRSAIERQLDELLKRSDDDAAALFARP
TLAKALQASTERDHLFVVLASPVAEVGRDHDYDWAIVEPSSMRSIIQLAGRIRRHRSGFSGEANLYLLSRNIRSLEGQNP
AFQRPGFETPDFPLDSHDLHDLLDPALLARIDASPRIVEPFPLFPRSRLVDLEHRRLRALMLADDPPSSLLGVPLWWQTP
ASLSGALQTSQPFRAGAKERCYALLPDEDDEERLHFSRYEEGTWSNQDNLLRNLDLTYGPRIQTWGTVNYREELVAMAGR
EDLDLRQCAMRYGEVRLRENTQGWSYHPYLGFKKYN
>cas__Q8U336 Cas3 | cas | Type I interference | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
MSCKAFQGQTLREHIEAMLAAWEIVKNKYIPSIIRVMKTVGVKFTEEDADKFMKTLIILHDVGKCSEVYQKHLSNNEPLR
GFRHELVSAYYAYNILKDMFKDETIAFIGALVVMMHHEPILMGQIRSLDKEELTPEVVLDKLRTFNGVMEGTESFIKSMI
KEKLGVIPKVPSPTQEDVLREVIRLSVLARHRPDSGKLRMVVGALLIPLVLCDYKGAKEREGESPKFAEVLRVEMMK
>cas__D4GQN8 Cas3 | cas | Type I interference | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
MTYPLISHPEANDGERTYPDEQLTDDGSLRLTAHNTVVSEYATRLFRGPETQRRFLCVAASLHDFGKATPQFQAYVRDEY
EGPEKEKNHARLGALATWFVLDQRDAPARDKLAATLAVARHHQALPDAAQYTAESLADAFETSNSVLTAQLEAISERWPQ
KATELLQRSGETDSTWDEFRTWVQSGTVVGELHEVSARRELTGPKATSDKLPRKLYDRTLHYWAAITLADKSHAMAVPES
HVFDVETLDRETLEEYISGLRAEPPDDELERALNDERERARRQAIDGVHEWLGGDAQTPPIATLTLPTGLGKTFTGLSAA
FEARGILESDGGPTRPIVYALPYTSIIEQTRSIFERPELWGADPTKSALTVHHYLSETVVYRNERESEDVASTDQEEHAS
FLGEAWRDGTVLTTFVQLFESLVGPSNRQGLKLSALDDGLVILDEPQALPKEWWDGITRLIELLTTEYQTRVIAMTATQP
TLLRDVETTSLLDVGREHDKTGCLRCEVGPDYPVRLEPARKETYFENAERVRYRIDESALSFHLSADERYLSHETAAARV
VAATAAGEGGSTLAICNTINSSATLTQELCGHDGVTHLGEAIDSVLGANDVDATKQENNVSAIVDAILRRSGLRGVDGEL
SVPAGTDIVVATLNSRYRPFDRRLLIEIADTLSGSEIPFVLISTQAIEAGVDLSFKRVFRDIAPLDSIVQAGGRCNRSYE
WGRNGGQVVVWTLADPDEENPGDPTKSPPAHWVYERGSSDAGIQTHLQLISSILAQFEDEEVPDAEISHHAVNEYFDALR
EKSLSSTKIRTLIDDAKAGKLARESLIGGYQTVDVLVATTQAERKRLNELTELFTSDDPTDRSTGYKKLEQAAGIRVSLP
LNSIEQLPDVSRVDGKERNEDGVQVFRYTGTESLEYDLQTGGLRGKEDTVAGRFTTF
>cas__O27158 Cas3 | cas | Type I interference | Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)
MAMMELIDIIRAKSNDQRNYLLKDHLKETVARIDDFHNFYQTNREKFSYKIGEKTFRALAMASIIHDLGKIDYNFQKKLM
GDDSEAWEVLEEFLSPLKPLKRSPRHEILSIIWSTFLLGNDDLDAMMRTAILLHHYNEYFLNDKDLMEIIFTYRDAFEIY
LNFIIEKKETLRIFIEDILNYIQNSLESDLVISAADEIRSNMDFEKPELLLEKIKEYDDDISEFAAFYEPEERSADILIL
SGILRRADYSASAGVDIELFSEEVFRDIDEKITSKIGGAPWQIRLMGELGGPKKMVLVAPTGSGKTEFSILWAAKHGRKF
IYTLPLRVALNDIFMRLRDSDGYFSEDEIDILHSTAFIEYLKEERLGRGTDLDSMMTSARLMASPALLTTPDQVLITSLN
YFGSDKVISVYPFASMILDEIQTYNEEMAAVIIKTLELVNEVDGNILVMTATLPPYFRSFLDAMNFEVMDVAAIPGAHDI
KNLNLKRHVPQLIEEPLFNDELEVSDKLGKILDENSEKNVLIVVNNVQKAIELYREYQDDPDVYLLHSRLLEKVKSQRIG
EVKKRSQDERGLTVISTQIIEASVDIDFDLMITEISTIDSQIQRWGRIHRNRDADYDSGDPNIIIFTDSDRRTSLIYDKK
VLDATRAILERYDGQILDYNLERSMIEEVFQEEIDGSTLKEIYENQIRETISDLDYFTVEKRTQAQRLFRNMAGYKVFIP
DAVLRYSESEIERTFAELIKGDYRLWKDILGEIERITGEKTTMWDLKKVLYEYSVNVPVFYEEKSDFWSRTTGEFKGFYV
WGSMEDDDVELLEELGLDSIFGETESSLIV
>cas__Q1CW46 Cas3 | cas | Type I interference | Myxococcus xanthus (strain DK1622)
MKRLLAKSTATPDRPEGEATLLGHTALVLSAARRLLEHRGRASLLAAGLDPALEPRLRRIVLLAAALHDLGKCSEHFQSM
LRRQREAPQLVRHEALSLWLCWPGQPLSAWLQRDVSELDLCLALVCVAAHHRKFQTEAFAPDGTGAGLSLELRVQHEDFA
RTLGRIAEELALSAPPLFTAPIVLRATRKEHPRDQLQSWQDDFERTVPAGSVDARLLAVCKALVLAADVAGSALPRSGEK
QDWVDRQLTAPHPAEALRAVVERRLAGHTPRPFQEEVARSAAPLTLVRAGCGSGKTAAAYLWAARQHPGRPLWLTYPTMG
TATEGFRDYLHGADVEARLQHSRAEVDFDIFGLRDGAAPGTSSRDQDRLDALRSWGADAMSCTADTVLGLVQSQRQGLYA
WPGLCAACVVFDEVHAYDDRLFGCLLRFLEALPGIPALLMTASLPATRLDVLRGMCERVHGRSLAEVEGPEDLETLPRYQ
RLDVAEPWALVAECLRDHGKVLWVSNTVDRCMRTAEAGTSHGARALLYHSRFRYEDRVRRHGDVIEAFATEGRAAFASTT
QVAEMSLDLSADLLVTDLAPIPALIQRLGRLNRRSTLERPAPVRPFVVLPFDGPPYAAPDLRDARAWMERLGTGPLSQRD
LVDAWGPPGMMDAPRRQSSTWLDGRFDTWPAPCRDGSPSLTVLLEEDARAVLDGAVSAHRVTLPMNLPPESFKWRAWPRA
GRLPYPIPPANALDYDGLRGARWRKP
>cas__A0A401FWW9 Cas3 | cas | Type I interference | Desulfonema ishimotonii
MEKELIFWGKSERKREAGELQWMSVWAHSLNVTAVAQAWLTERESLLTRWAALLGTDRNGITRQDALRVALHFTLLHDLG
KYHFRFQGKNAGLFEALNSVAIPASNGSFDHGAWGFQFYGRHLTGRPGVPEKTEWYHFMRAVASHHGTYADPGGRTPKKV
SGASVSADVLENARKRAVAGHIGRAARYFPLPEFGRFKNIRADAVVFLAGLCSVADWLGSDSDFFPCGPVRDTSEPEFIT
SAMTDAARAVLERNHLLGRYCGEPETRLSRIFPGIGRLRLRPLQQAACDLALNAAPRMIIIEAPMGEGKTEAAMILADRL
LSAGYAEKLYFALPTMATSNAMYGRMSAMMADSRFFDENSSLVLAHGKRHLKEEFQRHVRIPENRETISDAENPPAGMMC
SRFFSQSHKRSLLAQAGVGTVDQIMSAVLRKRHHWVKLFALSDAVVIIDEVHAYDAYMREILGRLASWLRAMGSHVILLS
ATLPHSVRQEISGAFGDLPDVRESREYPLMTHMVSGEKPRYIPCESVATSEKEVVFEATHDADAMADRVIRHARAGAQCC
VILNTVAKAQEFYGLLADSERCGGLDIMLFHSRFMFRDRNRIEETVLARFGKHGDRSRGRILVATQVAEQSLDVDFDVMV
SEIAPVDLLLQRAGRLHRFPENNRYRRGTPWERPRLTVFMPCETAARLLDDRIANPEARSVYDAAILFRTALLFENEDRA
LTVRIPDDIRPLVDRVYDGQEMEISPDDADRYEERWEEWKNLNYEQGVMGANAGRMMPDNRPGNLENKKSYQDDAAASEA
TDELQPDGTRLAPRSVRVVFADAAWLVREDLQDRAGAYRRFHMPLEEHSLSVIRGMLRGACSEAFNPHPDRMLPEEWHEI
RKRFEQELPRWETHLILPVPVTENERYAFGGSGVVLEYSASRGLKIEYPESEADSFFRLKPETLAKPAFENPEPAETELA
EPRKSRRPAAPAKDLIAKVRSNPLKSRISYLHVGHARLDVDDSGLVMTSADGDAFRQIPVASMTLILLEPGSVVTHEAVK
LCAKHKCLLIWVGEGGVRLYSAGYSDFARADKILNQARMYNEPKQRLAVVRRMFEIRFRKPCPRNKSIGQLRGMEGSRVK
KYYRELSGKYGVEWDGRLYDQSRWDRANTINRVISVGTSCLYGIAEAAILTAGYSPAIGFLHSGKDRSFVYDIADLYKEE
LVFPLCFELVRDNEPAAESLIRHHLRDVFKKTRFLERLIPDIEEILRPVE
>cas__A0A023D2M3 Cas3 | cas | Type I interference | Acidomonas methanolica NBRC 104435
MHDLSASSADPMSDTADSMNHCTYTDAGGCWAKLRRTCREQRGSACRNTCDCEVTGVLSLVGHSADVAAVLSALLEQSVI
AARLARLLGKASLSAEDRARICTLAALHDLGKISQGFQHAPFDRKYPQRGHIMPLVSLLKNGRDERDRKSAIQLRRLVTE
GGLGSLSALLGAGDQWEPFLATLAHHGDLPAPQPALALLWQATATHDPIAASRGLIEAIRLWFPAAFDGAGIDWTPRFGH
AFAGLLTLADWLGSDTTIFPMAGDGGAPDGTERYVWAKEKASELLARRLLAPETGRAACASFTWEIEPLTGFAAASAAQA
AVLALPSAPAEGRTCLIEDETGSGKTEAALIHFLRLFDEGAVDGLYFALPTRAAAVQIHQRIVKLLKKLLRDAAPAVILA
VPGYLDRASDAAAPLPGEAPLWPEEQEDAQWAAARPKRYLAACVAVGTIDQPLMGALRVRHAQLRSGAMLRLLLVVDEVH
ATDIYMTTILRHLLDQHRSAGGHALLMSATLGAFTRQSLLERRGRVSVADHQAAIETPYPAVWTDNAGFFANFAKPPEHE
PKSVRVTLNTVWDDPATVATFAAEAGRMGARVLVIRNTVGDVVATQLALEALEPGLSLAVHGRGGPVLAPHHARFAPEDR
RLLDGALEAVLGAHCERRGGSVTITSQTAEQSLDIDADLLITDLCPADVLLQRIGRLHRKRDRVPIAGFEEARVILLAPT
EDVFAACFNADGQMGRGQAPLALGLVYPDLLGVVATRRAIAASPDLVIPRDNRRLVEAASHPESLQSLAEELGGAWVKHW
WHILGTNAAQEGQAGIACLEWDKEIAAAIDLGEHIRVRLGLDDRLVSLPPATIGPFGHEISSLTVPGRWLSGVSAKEEPV
STPDEAGGLSIRFGDRLFVYDRLGLRRA
>cas__A0A059U354 Cas3 | cas | Type I interference | Salinispora pacifica
MEGVELGVDHDGVDAGIWGKSNHLPRPYPLLWHLIDTAAVAGALWDRYLAPNQRRVIAEGLATDDSHAKSLIMFWAGLHD
VGKATPGFQKKDGSAFDALRSAGSYEDVVGDGSLRHDTAGQLALPGLLAPLGYPQLVRRVSDRLAYRVAQIVGGHHGRFQ
QTSGPHGGQLQLGKGGWSKQRAALVRVVHEAVGSPKRPSAIGAAASVLVTGVVILADWLASQEHFLRQQSSRVPQYTGTE
AASTHLAALSAPAAALLDDAGLGSPSFRAVRFDDLFPHRPNALQRSIIEELLPVVDSPGLLVVTAATGDGKTEAALVAAK
RLAEVCGAHGFFFALPTMATSDEMYRRVRAFAARLAAGPAPVTLLHSMSWLNAEYEARAVVDPGGAAEVVSDDPSGDVVA
PEWLRGPKRGLLAPMAVGTVDQALLAVLTTKHNALRLLGLSGKVFVVDEAHAYDDFTTSLLCHLLNWLGAYGCPVVLLSA
TLPSSQAATLVGAYEEGAGVGPTNTSVPYPGWTFVPAIQGRATVSISPTMREALVSGRTVEFTLDVRPVRHLVGSERDPA
DRRAVVRQVLAPVAEQGGCAAVVCNTVSDAQQTYRVVRDWASEGVDVVLLHSRFPARRREEITTQITSRLGKEGNRPKSM
IVVATQVLEQSLDLDFDLLVTDLVPMAQLLQRAGRCHRHHRTRPPWAAQPRVVVLDPRGPDGVEHVRPAAWGDVYARYLL
RATHLRLMGVDTIAVPRAVQGHVEAVYVPQEIHNDPVLSAEHNECRAQAMAERGTAELGVIPEPVGLADLVALSQTETPE
WRASTRLGAESERVLCCYHDPDGMQWLDPQGRIPLPQRGSGPDGRFRSEEVRAILQETIPLRADILTGYDPPAALPASWG
NNAWLKRIRPLWLPILPTGPGPATWARRSVHLDPELGLVVATAGAE
>cas__A0A059U403 Cas3 | cas | Type I interference | Salinispora pacifica
MEGVGLGVDHDGVDAGIWGKSNHLLRPYPLLWHLIDTAAVAGALWDRYLAPNQRRVIAEGLATNDSHAKSLIMFWAGLHD
VGKATPGFQKKDGSAFDALRSAGSYEDVVGDGSLRHDTAGQLALPDLLAPLGYPQLVRRVSDRLAYRVAQIVGGHHGRFQ
QTSGPHGGRAQLGKGGWSKQRAALVRVVHEAVGSPERPPAIGAAASVLVTGVVILADWLASQEHFLRLQSSRVPQYTGAE
AVSTHLAALSAPAAALLDDAGLGSPSFRAVGFDDLFPHRPNALQRSIIEELLPVVDSPGLLVVTAATGDGKTEAALVAAK
RLAEVCGTHGFFFALPTMATSDEMYRRVRAFAARLAAGPAPVTLLHSMSWLNAEYEGRAVVDPGGAAEVVSDEPSGDVVA
PEWLRGPKRGLLAPMAVGTVDQALLAVLTTKHNALRLLGLSGKVFVVDEAHAYDDFTTSLLCRLLNWLGAYGCPVVLLSA
TLPSSQAATLVGAYEEGAGVGPTNTSVPYPGWTFVPAIQGRPTVSISPTMREALVSGRTVEFTLDVRPVRHLVGSESDPA
DRRAVVRQVLAPVVEQGGCAAVVCNTVNDAQQTYRVVRDWASEGVDVVLLHSRFPARCREEITTQIIGRLGKDGNRPRSM
IVVATQVLEQSLDLDFDLLVTDLAPMAQLLQRAGRSHRHRRTRPPWAAQPRVVVLDPRGPDGVEHVRPAAWGDVYARYLL
RATHLRLIGVDMIAVPHAVQGHVEAVYVPQEIHNDPVMSAEHNEYRAQAMAVRGMAELGVNPEPAGLADLVALSQTETPE
WRASTRLGAESERVLCCYHDSDGMQWLDPKGRIPLPQRGSGRDGRFRSEEVRAILQETIPLRADILTGYEPPAALPASWG
NNAWLKRIRPLWLPILPMGPGPAAWARRSVHLDPELGLVVGTAGAE
>cas__A0A059U442 Cas3 | cas | Type I interference | Salinispora pacifica
MSSFEAFFEQATGVPPYGYQARLARGGLPAVVQAPTGSGKTAVILAWLWRRLHGPVREGTPRRLVFALPQRTLVEQVAAE
VRRWLTSLGLSDEVALHVVMGGEGRTQRQWRLDMHHPAIVVGTVDSLVSKALNRGYGISRAVYPIDFALVTNGAQWIIDE
VQLCRESTTTLRQLAGFAAAAGSGWPTAEPLALTCMSATVSESLLDTVDNPLPGIDDVLRIGPEERVGELATRLNAKRTI
RRLPAEPGDHKAIAGAVRDRHRPGTLTLVVVNTVATARGVYTALRDSAAPRTLLHSRFRGVERERLVGQVVAEPGELGRI
VVSTQVVEAGVDISAAVLVTEAAPWPSVVQRAGRCNRTGRVADAELWWLPPAKHSPYERADIEAAVDELAGLEGVGVTGE
ELLARQVAVTEPEISVIRRGDLLSLFDTAPDLAGADLDVAPYVRDADDLDVQLAWGDWTPTDTTGRPPAEAKAPPAEWRC
RVPLGELKALRNRGAVVWRFDQAAGQWAQVTEGQPARPGEVLAVSAKYGGYDPQVGLDSSVKKPVADCPSLDARPNPAAG
TDPASGGEDAYQQDDASVAQREWLPLDQHSDDVRGQCEALLAALQPSLPAAVKRAVVTAGYAHDAGKCHDAWQEALCALA
PREERERVELGRPWAKSAVNGRLNFSRDGSFRHELVSLLLLDGPLRALLESTDAPDLVRYLVLAHHGKLRLQVRGPDDTD
AETLLGLKNGETVQFPDLLGQPAGELTVDLDQFSFGGDSSWTRTALGLRDRYGPFVLAYLETLVRVADWRASAGMGEAA
>cas__A0A059U4M5 Cas3 | cas | Type I interference | Salinispora arenicola
MLTVDHFADFFNEVHGGAASSGSRRDPFPWQTALLRRVVDDGWPDGIDVPTGLGKTSVLDMAVFAAALGVRDARRRVFYV
VDRRLIVDEAYEHARRIAAALDQPTGGATRTVARRLRGEDDEVALDVTRMRGGVTWERTWLERPDRYAIVTGTVDQIGSR
LLFRGYGVSDRARPIDAALVGTDSVIVIDEAHLAQAFVTTTQATFDLDSSPITRPPIVVTMSATTTVGRERNAGRSPVMH
RISDDDERHQIAGERLTAGKRLHLVEVKTTKKAEDTVLPAAMAALADRLAPGRVVGVVTNTVARARSVFELLRDQHDAVL
LTGRSRPVDRDCLLATYYPHISVDRDRSHQRPLIVVATQTVEVGANIDLDALITESAPLASLVQRLGRLNRVARSGHGHG
TAVVVHGSATGQEDPVYGPARLATWQWLSNKTDPASYTPRLDPTQLAPWLDASPAALRRLTARLTADEQAALRGPTPYIP
VVKRRHLDTWARTAPAPVPDQPIEPFLHGVTDDQPPIAVVWRHGLGPAHQWTDLVDEMPPVAEETLDLPVAAVRRWLLGI
GPDPTASDLDNTATTPPTTDVTTGQPPRIPRVLRYQGRGDAQLIAPWKVRPGDTIVVPADVGGCDEYGWHPTSTAPVLDA
ADLALRRGRPVLRIGPTLVDAARRWGEHLAALAQQLIDHATADTGASAASPAAEPYLLVLKAMREHAPEGPLREVLSALL
ATRPRVILRTSPHQGSQPHLGVIAAQHDRLADDDTSMGSSTAARRVGLQPHQAAVAARARQFAEALGLPPRVIDSVARAA
LWHDEGKRDPRFQIMLWGGSRAAADIAEQPLAKSGIAPSDRAAFVRARTAAGYPDRMRHESLSARIAAARLTGDHDIHSD
LVIHLVASHHGHARPLLPPVVDPRPTKVTVDDLGPFDTADTIDWQQPHRFSQLNDAYGRWGLALLETIVRLADIWCSARN
ETIEDKP
>cas__A3MTK6 Cas4 | cas | adaptation helper | Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)
MELLSPKPLCSVVNCEDLEKLDHVSALNELRREQEIFKLLPGIYAHRYDFRRVSPSIINDFEYCPRLLWVQHKLGLKLLS
EKSVVSIIRGRILHERYERLLSQYENVVAEYKVEIGDLVGVVDLVIKRGGEYIPVEIKTGFSKEAHKTQLQIYISMLKAR
FGYLVYRNHVEVVHRNDAALDVLKKIREILSAREAPPAKCNSCIFKPICKNLL
>cas__A0Q5Y6 Cas4 | cas | adaptation helper | Francisella tularensis subsp. novicida (strain ATCC 15482 / CCUG 33449 / U112)
MNMDIFDNDLSIPVNLIRQWCFCPRIVYYQELLAIKPNKPLWVAQGEEFHKKVEQLEKRRSFSRYGLENAIRHFNLSIKS
QKYKLHGIVDWVIETDTNVYVVEYKTNPNPNSLGHKLQIAAYALLVQEYFAKPCKTTFLTSDKKSYEIKITDELINKLIK
TISDILSTLDSGNKPDSSASDHQCIQCEYYNFCNDR
>cas__G4RJY5 Cas4 | cas | adaptation helper | Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)
MSLCINPSLIRQYLYCPMAAYYIAAGAPEPPTLRMQRGREIQQEAAQAAAKALGAERAEYSVHITAPPLCGTVDAVLWIN
GRPSPLEVKAAARPRRIPIHHKAQAAAYIAMVQRAYGRAVATAYIYYAESGQIAQIRMAKDLQELLNYAVSRLQQILQGK
PPVLNPNPAKCQNCWYRKWCSHLPTTVEKI
>cas__D4GQN9 Cas4 | cas | adaptation helper | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
MSSTDVVEEYVQDERDPSRSPNVPITGLMVQYYHVCKRELWFMANGIDIDRETTNIQRGTHVDETSYGTSRRSFMIDNRI
QLDILDSGDVMEVKVSSALEKPARMQLLFYLWYLREIHDIDKDGVLAYPTERKRESVVLDETTTAEVESTVRGVLDVVGR
DSPPQLEKKPYCGTCLYQDLCWM
>cas__Q2RRV2 Cas4 | cas | adaptation helper | Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1)
MAPSDTPPSAEDLPSQGELALFAPPATAEDALVPASMVNAWIYCPRLAVLEWGRGEKARSVDLIAGLRAHQATESGPTPA
LPDPMVLREDQSLKTRKLSLSSERLGLTAELDLLDVEEGVVIPVEIKVGKRPSVDEGAYLPERAQVCAQALLLREAGYTC
LEGALWFAESRERVTVDLTEALVTATLVATSDLRLTVASGRLPPPLDHSAKCPRCSLLPICLPDEIAWFRKGSIARTPPP
PASPALPLYGQTPGARIGKKDRGGSVCLDRMAAWLSSRPVPCYAAIGMLNTASGASHPSVARHADGGASARSFRLPTAFR
RPVRRSLPCYAAR
>cas__Q57822 Cas4 | cas | adaptation helper | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
MENYLEEELIIGGIEINYLYVCKTKLWYFVRGITMEQESDFVDLGKFLHEKSYFGEEKEVQIGSIKIDFIKKRDVIEIHE
VKRGKQMEKAHIMQVLYYIYYLNSLGIKSKAILHYPKLKEIKEIELKENNKEEIKRAIKEIEYIKSLKEPPEPIYQKICK
NCAYYELCFI
>cas__A0A0B7P1T1 Cas4 | cas | adaptation helper | Propionibacterium freudenreichii subsp. freudenreichii
MSGDDKLPISLVAHTVFCPRRAWLEAQGEQADSYAMTAGTLAHRRVDQPAESRPEVRRAVSVHSESLGITGRCDVVEVSS
DGLSVVEYKSTPVRRKAEITPAQAVQVGLQSMCLEEMGHHVTSGVVHFVNHHKDVPVPLGAEAREACRDWVTETRKVVEA
DSAPPPLLDDSRCNGCSHATICLPDEQVHNGGELKRRISVADPHGEILHAVTPGARLSMRDRQIRITRQGEQLAAVPLER
VQGLVLHGNVDVSGALIREILWRRLTIVWCSGRGRVVGWATGAAAPNGQARMHQQALSEVGCLPVARAIVRAKLINQATL
LRRNAAAATAPQEIRELSRVAMRVESLPELFAVEGRAAKAYFSEFPLILKSDSAQDFLDGWPGRHGRGAIDPLNAALNYA
YGMLLADCVRAIAACGLDPHGGFLHSPSRNKPALALDLMEEFRAPVADSAVITCINNQTLTADMFSHTLGDVRLTRAGIA
ALTSAYERRVTTDIKHPTFGYPATWRRTMEIQARLLLGFIDGTRSEYIGMTVR
>cas__A0A0F6HEC4 Cas4 | cas | adaptation helper | Leptospira interrogans str. UI 12621
MGIHSLLYCERLFYLEEVEGILVADDRVYAGRTLHEELEPNEDSSGRIESFHYTSEKLEVSGKVDRIQKRDGDWIPYEHK
RGRARIGTNGPEAWESDQCQVTVYALLLEEATGRNISEGKIRYHGSKDLVKIEIDEELRSKALKAIDRAKELSTSTNRPP
VAQNENLCKNCSLAPVCLPEETRVITENEYEPIRLFPEKREKTTLHVFGHDSRIKKSDNVLLVEKVTETGEKSKSEKIPI
QEIESVNIHGNCQISSQMIKFLVSEEIPVHWFSGGGNYIGGININPSGVQRRIRQFKALTKETIRLNLAKKLVSAKCESQ
LRYLLRATRGKDETRNETESYLATIRSGLKNIESADSPSQLLGIEGSSARAYFSGLPALLKNSDPFLVPNGRSKRPPKDP
FNATLSFLYSLLYKSVRQAIIAVGLDPSFGFYHTPRSSAEPLVLDLMELFRVSLCDMTLIGSINRKSWIDEDFEITKNKV
WLSESGRKKATQLYETRLDDTWKHPVVNYSLSYYRMIELEVRLLEKEWSGEANIFAQARLR
>cas__A0A0H4X8Q1 Cas4 | cas | adaptation helper | Pseudomyxococcus hansupus
MSPKPANTEPSIRTHALHALAYCERLFYLEEVEELRVADAAIYAGRRLHHQLQEEGERVELELASEALGLHGRVDAVRTR
EGTLVVHEHKRGRHAPAPEVPGAWPSDRLQVGAYALLVEERFPGVPVECRVRYHQTETTVRFPLDAALRGEVASAVARAR
LLRASRERPPVTQEERKCAKCSLAPVCLPEEERQVAGEDRPRLFPEDDVRQVLHVATPGTRVGRASEELVVTPPEGEGAP
SRQPGRMVSALVAHGAVQVSSQALAYCVENDIGVHWFTSGGRYLGGLGGGTGHVHRRMRQFEALRQESVSLGLARRLVAA
KLEGQLRFLLRASRGDADAREVLASAVRDLRALLPKCAEAPSRDVLLGLEGAGAARYFGALPYLQGEDVDPRLRFDGRNR
RPPRDRFNAVLGFLYGMVHREVDAAIRSVGLDVAFGFYHQPRGSAGPLGLDVMELFRVPLADMPLVASVNRRTWDVEADF
EVTSEHVWLSKAGRAKAIELYERRKRETWKHNVLGYSLSYARLVELEVRLLEKEWTGKPGLFATFRLR
>cas__A0A0H5BQ26 Cas4 | cas | adaptation helper | Blastochloris viridis
MSSSDTRSDPPAGSAPGQDALGQNLSDQGAAAPARPAARQGELALFAPPAAADEMLAPARMINEWVYCPRLAVLEWGRGE
WAGNADTAAGRRAHKATETGAAPALPEPDALPDDRALKTRRLLLASERLGLTAELDVIEADDGRVVPVDIKTGKRPHVAE
GAYLPERVQVCVQALLLREAGYTCEEAALWFADSRERVRVELTDELIATALGAASDLRLTVAAGRLPPPLDHSQKCVRCS
LLPICLPDEVNWFRKGAIARTPPPAATPALPLYVQTPGARVTKKDFTLVVQVEGEADRAVALDEVSELVLAGPVSLTTPA
VHELLRRDVPVAWMSSGFWYLGSTGGQGPRSATVRTAQYALAADEPRRLAFARELVAAKIRNSRTILRRNWRGEDGERGP
LLDRLALLADRTARAETAAALLGLEGEAAALYFRALPKLFTDAVAALPAFAFERRNRRPPADPVNACLSLIYAVLTRTFS
SAISVAGLDPWKGVYHAERPGRPALALDLIEPFRPVLADSAVLMALNNGELAPDDFVSAAGGCNLKPKARRALIAAYERR
LDQETTHPAFGYQVSMRRLIQIQARLFARFVCGEIPRYPHYVPR
>cas__A0A150Q5M5 Cas4 | cas | adaptation helper | Sorangium cellulosum
MSSESAEPSLRVMSLHALAYCERLFYLEEVEEIRVADEAVWAGRQLHAELDEPGDVVEMTLESATLGIRGRVDALRRRSG
ELFPVEHKRGRARRGAGGEPAAWESDAVQAAAYAMLLEEHAGRPVVEARIRYHRDNVTVRLPITEAERAAVVRTIARARE
LARSPDRPRVTEDERRCVRCSLAPVCLPEESRFAEAEALSLPPAADRGPPGVLAPGGATAASRAAVEALPSPVRLYPPDT
ERRSLHVVSHGARVGRSSDAFEVTEREGERTRIGAREVSDIVVHGHAQITTQALRLCAAEEIAVHFVGAGGAHVGVFSGG
SSGVQRRIRQFRGLTDDAFAIGLARRLVMAKIEMQLRHVLRASRKDDALRAGIEEPIEMLRGSLRRAARAMDRQSLMGQE
GNAARAYFSALAALVHPDAGDALRPRGRSRRPPEDRFNALLSFGYTLLYRDVLSAILRVGLEPGFGVLHQPRSAAFPLAL
DLTELFRVPVVDMAVLGAVNRRTFDAGRDFAVTGRQVWLSDVGRRAFIDVYERRKHEEYRHDVLGFSLSYARMMELEARL
LEKEWSGEPGLFARFRIR
>cas__Q46898 Cas5 | cas | Type I Cascade (RAMP) | Escherichia coli (strain K12)
MRSYLILRLAGPMQAWGQPTFEGTRPTGRFPTRSGLLGLLGACLGIQRDDTSSLQALSESVQFAVRCDELILDDRRVSVT
GLRDYHTVLGAREDYRGLKSHETIQTWREYLCDASFTVALWLTPHATMVISELEKAVLKPRYTPYLGRRSCPLTHPLFLG
TCQASDPQKALLNYEPVGGDIYSEESVTGHHLKFTARDEPMITLPRQFASREWYVIKGGMDVSQ
>cas__Q746C2 Cas5 | cas | Type I Cascade (RAMP) | Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)
MARLKVKVWGEYACFSRPEFKVERVSYPVPTPSAARGLLEAIFWKPEFRYEVRRIGVLRLGTPFALLRNEVGNRMGAKPF
FVEDARQQRTSLVLKDVAYLVEADMVLRPHATDPLPKYLEQFERRLKKGQYHHTPYLGTREFPAYFSPPDGEVPDGGLNL
DLGPMLFDLAFVEDPGRPELTFKRPGRGEVQGYALPLFFHARIREGWLEVPAEKYQELYRLEEGHAKGA
>cas__D4GQN7 Cas5 | cas | Type I Cascade (RAMP) | Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)
MSPHIDANGVPIDCLSFTVRSTWGHFKRVGRSVTKQTYRIPPRTTVAGMLAAIVGADRDSYYDVFGADNSAIAITPLSDL
RTVNIPTTGLGTDPKQDVTETAGSWRTYKLTYQNTTGDRQLHSYEVLADPAYRIDVALENEEFYDSLREHLVNGTSIYPP
SLGKSEYLAVIEDVEVDREPEVQDIDETLDIDSVVPISLSEAVPQGKVTYGVERSPAVMVRESGGRRTTRFDDYVYAQQA
SNPVRIGEQTDVAPVQVGDRTVVFR
>cas__G4RJZ2 Cas5 | cas | Type I Cascade (RAMP) | Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)
MHYYLIEARAPLYSVKVVDVYQVASAYPLPTPHAVVGALGAAMAHAGMCRGLQCMKEAEGLVVAARPAAVGELAKFPAVL
WRTRGVLEDKSLPAGLEDYAGARDAMVREYVYAHAVKILLVTRKRVPQHVIRLMARLGDSESYVSVVDVLEGKPRECGGL
VNVAVRAAKARRGSYTLYRALDERGNRELFAYPVVEEGGVYRRGGVEVGSKVLCLGEAVFPEGDGW
>cas__Q65TW5 Cas5 | cas | Type I Cascade (RAMP) | Mannheimia succiniciproducens (strain KCTC 0769BP / MBEL55E)
MANRIRLHIWGDYACFTRPEMKVERVSYDVITPSAARGILSAIHWKPAINWVIDKIYVLKPIRFESVRRNELGAKISESK
VSGAMKRKSVADLYTVIEDDRQQRAATVLKDVAYVIEAHAVMTSKAGVDENTTKHIEMFKRRALKGQCFQQPCMGVREFP
AHFALIDDNDPLPLSQLSESEFNRDLGWMLHDIDFEHGNTPHFFRAELKNGVIDVPPFYAEEVKR
>cas__Q57827 Cas5 | cas | Type I Cascade (RAMP) | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
MIMEALVALLRFPFYSFGKQSYQVRQSLLLPSPSALKGALAKGIILLGGKKGKSLDEIAKKTVEELENKLIYVGAKPYKS
SIIKTPILLKRLRNLEDQKNPEKSDAMRREYVFAREILAIYVFRRKLSEEEKDLMLKAVYLIDQLGDTECVGNVIKTEWV
EVKEEKAPLKTYVKFKKVSKMSINGGIIENMLETPNFGNKVKEEPYLLPLIEKRYRRSSYYVESDRIFDGNYKIIAFDEV
IGLWI
>cas__A0A060NQQ0 Cas5 | cas | Type I Cascade (RAMP) | Serpentinimonas raichei
MKPFCLEVRGDYACFTRPEMKVERVSYDLITPSAARAVFEAILWKPVIRWRITRIEVLQPVRWTSVRRNEVGAVASSRNA
LAAMNQGHGELALYIEDERQQRASLLLRDVAYRLHAEMEMVGEEALANPNKYIAMFTRRAEAGQCVNQPYLGCREFAAAF
RPVELVGDGRGGWRVGPDEPSALDDWSPDLGWMLYDMDFAAGPTPQPLFFRAQVQRGVLDLSRVEVRG
>cas__A0A069ST70 Cas5 | cas | Type I Cascade (RAMP) | Phocaeicola vulgatus str. 3975 RP4
MEYTDKEYCLEVWGDWACFTRPELKVERVSYDVITPSAARAIFEAILFKRYAMRWQITKIEVFRPIKWATIRRNEVGAVV
NSSMKPIYIDDGKTRQQKNTLLLLDVRYRIYAKLVFIPVKDRPKEAFAKHQPSADENPMKYYQMFERRASQGQCFTQPYL
GCREFSANWKYIESTDNLDYPLAEDRDFGIMLYDMDFEENPQKPNAMFYRAQMKKGVIVVPDKDSEEVLR
>cas__A0A072NSM0 Cas5 | cas | Type I Cascade (RAMP) | Schinkia azotoformans MEV2011
MGQIFQLKVWGEYALFTRVEAKVERVSYPVMTPSAARGILEGILWKPEFKWRIKSIHVLKPIQYYSILRNEVASIVPSNI
AASRRDYFTDDDRQLRHSIMLRDVAYIIMAEMQLMNPTMENQMKYASMFLRRVNKGQCFHRPYLGTRECSLHFSLPEDED
QAIPVTMDIGPMLFDLKYPADPGQKNAHAIPYFFDAKLDRGVLHVPEYLYKEVDG
>cas__A0A089HIB7 Cas5 | cas | Type I Cascade (RAMP) | Paenibacillus durus
MRNQIEFEVYGKYGLFTDPLTKIGGEKFSYQIPTYQALKGIVESIYWKPTLIWIIDEVRVMNPIQTESKGIRPIEYGGGN
TLSYYTYLKEPRYQVRAHFEFNPHREDLIQDRNEHKHHNIAKRAVQAGGRRDIFLGARECQGYVEPCEYGKGTGFYDEIA
EIDFGIMVHGINYPDETGRKERETRLWRPKIEHGIIRYIRPEECTLLRKTGEGHIKSFGLADIQSVDELYADYFQGEERG
>cas__A0A090J4C4 Cas5 | cas | Type I Cascade (RAMP) | Caldibacillus thermoamylovorans
MRNSVEFKVYGDYALFTDPLTKMGGEKLSYQIPTYQAIKGILESVYWKPTILYVIDEVRVMNPIRMESKGIRPIEYGGGN
TLANYTYLKDVCYQVRAHFIFNPHRPDLAFDRNEHKHHNILKRSLKAGGRRDIFLGTRECQGYVEPCVFGEGESAYDGIE
EIHFGTMVHGINYPDETGKDQMEIRLWNPVMKNGVISFIRPDQCTQVRPIADMKAKHFDEKNMESVERLYEELEGGRE
>cas__A0A098R0A4 Cas5 | cas | Type I Cascade (RAMP) | Spirochaeta lutea
MEHFYQTFCLEVEGEFACFTRPEMKVERVSYDVITPSAARGIFESILWKPSLSWQIKKIEVLNPIRWTSIRRNEVGSYMS
HRSDGVYIEDSRQQRAGLLLRDVRYRIHAELRFNPDKGESRQDENPGKYNAMFERRAKKGQCFNQPYLGCREFSCRFTLI
ETTNKDEPQPIPEDKDLGFMLYDMQFPKPDDKDQEIHPAFYRPRMKQGVIEVPDWTSEEVYR
>cas__A0A0A3AD54 Cas5 | cas | Type I Cascade (RAMP) | Gallibacterium anatis
MKNNVRLHIWGDYACFTRPEMKAERVSYDVITPSAARGILSSIHWKPAINWVIDKIYVLKPIRFETIRRNELGHKISQSN
IKTAMKRNSLEKLYTIIEEDRQQRAATVLKDVAYVIEAHIVLTDQAGESDNLNKHLEMFQRRAAKGQCFRHPCMGVREFP
ANFCLIEENEALPQTALSGAELDQDLGWMLHDIDFNHNNTPHFFRAKMQNSVITVPPFYSEEVKL
>cas__A0A0A7I491 Cas5 | cas | Type I Cascade (RAMP) | Bifidobacterium catenulatum PV20-2
MQRHRNSIEYEVSGRYALFSEAATRVGGEKFSYQVPTYQALKGITESIYWKPTFMWVIDAVRVMNRVQTEGKGIRPIKMS
GGNDLSYYTYLKDVRYQVLAHFEWNDQREDLVADRDENKHHNIALRSVQKGGRRDIFLGTRECQGYVEPCEFGSGEGFYD
GYGEWNMGYMFHGFTYPDENEDHDFIARFWSPVMSDGIIEFERPESTKLDGRIIRKNQSVKEFALGSNLQPVGEE
>cas__A0A0C6FCF8 Cas5 | cas | Type I Cascade (RAMP) | Methylobacterium aquaticum
MGYGIKLHVWGDRACFTRPEMKVERVSYDVMTPSAARGILEAVLWKPQMRWVVDRIHVLRPIRFQSLRRNEVEDKVSSAL
AERAMQAGSTAGLGLVVEEKRQQRAATLLTDVAYVIEARFALTDKAGRDDTPAKYLSMFNRRAAAGQCFHRPCLGTREFP
ADFALLAEADPLPESTLPADQRERDLGWMLHDIVGPERASRFFRARLADGVLDVRACLAEGTTT
>cas__Q97WV8 Cas6 | cas | Type I/III crRNA processing | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
MPLIFKIGYNVIPLQDVILPTPSSKVLKYLIQSGKLIPSLKDLITSRDKYKPIFISHLGFNQRRIFQTNGNLKTITKGSR
LSSIIAFSTQANVLSEVADEGIFETVYGKFHIMIESIEIVEVEKLKEEVEKHMNDNIRVRFVSPTLLSSKVLLPPSLSER
YKKIHAGYSTLPSVGLIVAYAYNVYCNLIGKKEVEVRAFKFGILSNALSRIIGYDLHPVTVAIGEDSKGNLRKARGVMGW
IEFDIPDERLKRRALNYLLTSSYLGIGRSRGIGFGEIRLEFRKIEEKEG
>cas__A0A0A7HF73 Cas6 | cas | Type I/III crRNA processing | Streptococcus thermophilus
MKKLVFTFKRIDHPAQDLAVKFHGFLMEQLDSDYVDYLHQQQTNPYATKVIQGKENTQWVVHLLTDDHEDKVFMTLLQIK
EVSLNDLPKLSVEKVEIQELGADKLLEIFNSEENQTYFSIIFETPTGFKSQGSYVIFPSMRLIFQSLMQKYGRLVENQPE
IEEDTLDYLSEHSTITNYRLETSYFRVHRQRIPAFRGKLTFKVQGAKTLKAYVKMLLTFGEYSGLGMKTSLGMGGIKLEE
RKD
>cas__P9WPJ1 Cas6 | cas | Type I/III crRNA processing | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVGFSHRGDRRMTEHLSRLTLTLEVDAPLERARVATLGP
HLHGVLMESIPADYVQTLHTVPVNPYSQYALARSTTSLEWKISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRS
LEQNPLSQFARIFYARPETRKFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAIVDGEEPDPGLIAEFGQSVRLSA
FRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYIAALLWFGEFSGCGIKASMGMGAIRVQPLAPREKCVPKP
>cas__Q97Y96 Cas6 | cas | Type I/III crRNA processing | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
MPLIFKIGYNVIPLQDVILPTPSSKVLKYLIQSGKLLPSLNNLITSRDKYKPIFISHLGLNQRRIFQTNGNLKTISRGSK
LSSTIAFSTQVNVLPELDEGVFETIYGKFHITIESVEIVEVEKLKEEVEKHMNDNIRVRFISPTLLSSKVLLPPSLSERY
KRVNAGYSTLPSVGLIVAYAYNVYCNLIGKKEVEVRAFKFGVISNALSRIIGYDLHPVTIVIGEDSKGNLRKARGVMGWI
EFDIPDEKLKRRALRYLLASSYLGIGRSRGIGFGEIKLEFIKREENH
>cas__P9WPJ0 Cas6 | cas | Type I/III crRNA processing | Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)
MAARRGGIRRTDLLRRSGQPRGRHRASAAESGLTWISPTLILVGFSHRGDRRMTEHLSRLTLTLEVDAPLERARVATLGP
HLHGVLMESIPADYVQTLHTVPVNPYSQYALARSTTSLEWKISTLTNEARQQIVGPINDAAFAGFRLRASGIATQVTSRS
LEQNPLSQFARIFYARPETRKFRVEFLTPTAFKQSGEYVFWPDPRLVFQSLAQKYGAIVDGEEPDPGLIAEFGQSVRLSA
FRVASAPFAVGAARVPGFTGSATFTVRGVDTFASYIAALLWFGEFSGCGIKASMGMGAIRVQPLAPREKCVPKP
>cas__A0A7V3N5B2 Cas6 | cas | Type I/III crRNA processing | candidate division CPR3 bacterium
MSASLAKEVQKGLRQSQDLFSLQWHRLRCTFINTRSVPGKTLHTFIVFQAIVKLITSLMQENSPNEVQPDVIFHIVDKGF
AFKAREGDSFSVDFLFFRAPQEWVEEWCATLADYFASSRPGINYQIIDISAPEERTLSQLITESPIMKQEGELCLKFLTP
IPFKRQKGWNRTYLSTETFIKILEQRFSRLFHKEITYKGKRDAFSILPYYWKYTEIRRSSMSQPGTIQYINGCFGPLYLK
GAFTEFLPFLILGSEIHAGTKLSYSQGYYKLLEDSPPYFAKFFPNKKSLLSVIAFVKERDDSLLTSLEEAEDLITNEEDF
ADRLVAELQNDTYVPSSSTAFSIPKREGGERVIERLTLKDLIVSQYLLKTISEAFDRFFEESSIGYRKGISRQKAVELIE
QAIQDGFQFVVEADISDFFPSIDHDLLFALLDAYIPESDHLLNTLLRKCIKRNYLFNGRLHERIRGLCQGDPLSPILANL
YLDSFDEQIEQENVRLIRYADDFIILTRTREEAQRIFSKAQSFLAGLGLTLHREKTHISAISEGFQFLGITFRGSEAQVA
PEEEIKRFKKPLYIAEPYLFLSLNGEAIDVLRKGKPVETIPLRRVSEIIIMEKASFSTGLLTKCVQENIPITITLGSGYF
ITTIKPDSKFYYTLASEHARKYSELTPTEILTIAKEFAGIKIQNAITLFRQKYKNGMHQLIAELEEMASRIYQAPSIEEV
RGMEGASARKIYKALNLLIDDSRFHLKKRERARPDRINSLLNFGYYLLYSRINATLRAVGLNPYLGFLHAPQDTYESLVA
DIQELFRARIDRFVIRLVNLGIISAEEFIETEKGAYLVPDAKKKFLAQFERELIKPSASPKDRLCLLDWIYYQIVVFKKW
VCEEGSLIFYRWER
>cas__A0AAU8GZK4 Cas6 | cas | Type I/III crRNA processing | Thermodesulfovibrio autotrophicus
MQNLFSDIHWFRVKAGFEAKNTLSTSVYSIIEAVTKEVNNAIAFNNEKIIFHINEKPLKYRLSKNKKFHVTFLLLTTPQQ
ATIFYNAIQVYFQDPWNSRNIRLLEISPPEFRNYSLLYEELYEKLAKQQELCIDFLTPLAFKPSHPKKRAHISLSEFLSL
LSSRLKRLFHIESSITFNEEKTVFLPYWSYEELAVESLSQRGNTRYINGCTGKIYLRGEVDTVLPYLILCSELHAGSHLS
YGRGYYIIYQDNSPSYINSIPIIETLQFYVDKNKEKFNGLNSQEITKQLYNSFITADYEPNASEAFIADNILTEKLYWKD
QILHSFIYKILKNPVDNILPLTVLSFRPHISGKDIKARIDELITSGYDKILTFSIDGFYTQIDHTKLLNQLKRIIPLSDH
FIIKLIEKLLKAGYIHEGKLLTRKKGLPMGSPLSPLLANIYLIDLDRALNDSETVALRHADTYLIFSLSEEALNEKLNQA
KQLLQNLNLRINERSIKYDSQESITFAGIDIQTPQHQQRLRKPLYIATPDTHLSISSDTVKITNAQGENQTVPLNRISEI
IINTDTVITTPMLRKCIKNNIPLIIASNFMSPVIIVKSDHKSHYESIVRHTTKYYSLTDEMINLYAKQIVSLKLKSYEIF
LTYKRNLFASPIKDKLKHLRQKIIEATTLETIRGYEAIAAKEIYAALNLLIKNRDFHIKTRKRKTPDPINSLMNLCSHLT
FNRIRTVVCSNGLNPYLGFLHSPDNNYESLVADLQELLRAKMDNFIVNLINLKVIEKKDFKEIDGAFVLKSSMLDTLIVH
YEEYLNKFYSIGSSTLNDFIYAQVEKIKNWITKDEELIFEIPW
>cas__D2R8Z2 Cas6 | cas | Type I/III crRNA processing | Pirellula staleyi (strain ATCC 27377 / DSM 6068 / ICPB 4128)
MQIFRVRVLLRIKTATRMHAHHAAILYALLCEAHAAAHQIDPCIPDGLLLDAPEQARLMLAAGSKYAFGFTLLAPTERQA
CTVVDHLVRGLRKVGRAKTKPKPALGGNFEVELVEDLVAKQTHRTGHPLQPIAIEAITQEIAALEGLVQLTLQFHSPLRA
HRPKKARRDGHQFFDDHYFHPQALLHRLQSRIESLGICPAPFQPHLRPQAAAPLDGWPEPASPLPEDAAEPISHSPIPAV
VSNELVWLDVSYGPRHSRKTLGGAVGSVKLDGLQPATIATLVWGQYVRIGEGTRFGFGAYRIAELASDPYVCERSTRLLD
LATEHPALDQAASKWDLGGGEVQSAARDLVKGTYQPQPCFRLDIPKSNGDRRQLAIPSRLDRVLQRSILDVIAPALELFF
EESSFAYRRGLGRHTAARHLSQAFTDGYRWALHADFFDFFDTIDHKLLRRRLAAYLADPSLVEVIMRWVETGAPHPDHGI
PTGAPLSPILANLFLDQFDEAMHSVGRRLVRYADDFVVLFRDQSEAQAVISEVRQAAESLRLELNRDKTHTLHLATSFDF
LGLHFEPREIWEVTTIDEPQLIEQLGWKERSRKPSGGVLHPLPGESQLATPLPGTLIAGPGIEEILVHGDVLQFKHQDQR
GIESIPLHTLREVVVLGAVSLSHRVLSAIQQNAISLLLLDESANRTAYIDCQNAEPDSAGIEAQVDLIRNPESSLAIARQ
LISAKLHNYATLADAYPPKSHSGNAHRSLMRLAKDAQQASSLPELLGIEGSGAALWYGEIGMRLSPGFHWERRVAPNAHD
PVNILLNLAQTVLYRMTQHAIAQAKLVDTLGFLHQPRAGHAALASDMQEPFRHLMDRAVLETVRRIRPEEFEPDERGPFP
VRMKPRALRESLAWIHRILALPCNGAGQSSPTAYRLQIFKQVRSFRRFLMDPGGRFEPFRHP
>cas__A0AAU8LQX1 Cas6 | cas | Type I/III crRNA processing | Candidatus Electrothrix aestuarii
MQEILPCFRPLLDLSWQTLRLELRNTRNTFARQHPLAVFAAICKEAAKRAGIAHHEYFYHPLEGPPDERIRKNTLYPLEL
VFPGSDNTIGPRFLSGLSEHLNNPRNNFALHSHAPARPRSLNDLLQENPLLNAQEICLDFITPLPFTPKERSQRHLIDRD
IFFRKLEARIKRTFNLHLPGIEATWAGLRLLSCYWEYYERRRDSGSNQGKQYLNGTVGPLYLRGDISPVYPLLLLCSEIS
SGRRSSFGLGHYRLIHNRVFFESQLTDRTLFLGLRRDFLEQSDHETDIAGELLAPEQAEEEFHQALLDQRLNLGPAHHAG
IPKKDGSLRSIAILPAEGHFIHFLLNTLLSPVLDKLFTDAVIGYRPHRSRNMAKKRIIEAFHEGFSYVLKADIASFFDQI
CWQNLEDKLDAVLPLADTRMRQLLRQCIRTQVAGPEGIIPRDKGLLQGSPLSPLLSNLYLDDFDEQLAAMGYRVVRYGDD
FVIMLRSPTEGEVALADIRILLEPLGLSLQEEKTILQPLDMGFTFLGLEFGAMIDEEFVERTTLKKTLFVQEQYAFLGID
SQSIVIRKGKEVLARLPVHCISGIVLFGANTLSTRLLQRCSQEHIPVSFCSPAGLYVNTLKPDSRNFFHLLAEHSNQHAA
LSATEQVKIATELVTAKIENYLVWLQGRREPEARELLPKLEQTLIALSHCADLNEVLGHEGRATKLLFRAVNSLVQEEEG
QTFFQARTRICHCRADPYNSLLDFASFLLFCKLNVLVRTRGLNPYLGILHSRQDSYESLVADLQELFRCRMDRMVLRLLN
LRIIQARDFEEDTRGGVRLNRQASGRFLDYFERELSLRLTGEPGTLKQLLVAQVGVIAAWARDKKRLLWYNARSYEKE
>cas__A0A1H6FI77 Cas6 | cas | Type I/III crRNA processing | Candidatus Venteria ishoeyi
MSTIAPAPNAALLPLKAVTITLEFTSNAQLPFFHQPIVNAWLRHLGKLADYENYLSIDTPESGCIQYHKQDLYRFSLLCI
RGGENQLQTLLEKLQALPGSVTHNEAGQALRDNLKFHSAHDLFQGQAINHSSELTPYTEQSLAAEMQLWQHAPTVLLRCL
SPLRLLLPKAQRKDYTGEARFCRQTTELDFKLLQQSLYNSLNALLRKHRQPVMAMPETPGHFLEQHLFWMDNRYGADNKQ
KPMGGFLGLLQLDTRHFTPENWSNWVLGQYLGIGRFRVFGWGRYQLEGQAGETSLPRCQQATTLLKRSIEPDNFSSAYQV
VADNQQHKKLSARSNQSGVDVSEPDIDEAETQDGVPLERLQRIATQLKTETYAIPPLRGVILPQAGRDPRPLSIPPFMDR
VAQRAVAQTLTPALETLMYRGSFGYRRGRSRHNAAKMIQQAYTAGYRWVYESDIDDFFDNVLWSHVHTRLRALFGTDPLI
DLIMSWISAPLTFEKQVITRHNGLPQGSPLSPLLANLLLDDFDSDLETAGYKLIRFADDFVILGTSREEVEQAGQLAAAS
VSELGLQLNSHKTFISDFNQGFRFLGYLFVNSLALDVGGEKDLTHAPSTPPNSWLAKVEPQTSAKTSEALPNPKPETIDK
KTAIKLGERESLGIMLFISGDSALLTTREERLHIEQKNQPQNPAKICDFAWNNLQAVVLFGFHHITTPALKAAFKHQVAI
HYASNRGLYQGMSSSVKTYHDNSALWLAQHLCFQHEVQALSAAKSIVKSRLRHQSEILRRRNPDKQLNTPIQQLQGLTGK
IDHAPGRDNLNGYEGQGAKIYFQALQSLIPEAFGFSGRNRRPPRDPFNVLLSLGYTVLYSHVETLCHVSGLQPWVGLYHE
PHGRHAVLASDLMEPFRHIVERVALSAVRRKQITPDDFSTQADGSCYMAGEARKKYLALLSEAFETPFQARNDEQAYKLH
EHLHRQNLQLIQWIRGKIPQFQAWRMH
>cas__A0A7G1H193 Cas6 | cas | Type I/III crRNA processing | Dissulfurispira thermophila
MVTDFLNNLSWYRLQTELINIRLIKSAIAHPVSVFEAIVKGTSLSVNHNQPVIFHIKNRGHTFRLKNQEKILLDILFFLS
SEDDVLKWKEGFIDYLKDEETGKNFDVLFISAPQLRTLNNLYDEIGEIPEKGEVCLDFLMPLHFNREKDKSRTFLSKNTF
VNAFLSRIKRLFGVDIKYSFSKNFDILPYYWRYTEIKHASYSQKGHIQYINGCVGKLYIKGNLSEVSPFLVLGSEIHAGV
KLSNSFGYYILQIDPQSYFDRRILNRGAVISVIQDVLERYDVSDMVSKECKPTGKSNIDTLLNEDKLADQIVSDLIAGTY
TPEPNTAFRIKKKDGTFRLIEQLSLKDLIVSQLLLKFLSEPFDRILEESSIGFRKGISRERAIELFEIAVKEGYHYVIES
DIEDFFPSVSLEILNILIDHYIPSKDIITKTTIKKLLTNGYYESNTYHPRTKGLAQGNPLSPLFANLYLDTFDEQIAGMN
LRLIRYADDFVILTKSKAEAEEALLKTESFLSDLGMRLKKEKTAIKSVFDGFEFLGLQFKKGEVIAISGETVRRFKKPLY
ITEPYVFISLNGDTISIKKNGQTIESLPIRRLSEIMAMGNVALSSSLIKKCTEWNIPLTLTLGSGYFVTTIKPETKAHFD
ISYQQANKYYNLSDAMRHEIAKDIVLSKLENYKTLFRSKRLSSDAPIFHAIDRALDSVNLSTDLNELRGIEGITSKMFFG
ALNTLIDNPAFHIKHRRRESPDRINSLLNLAHYVIFSRINATIRSVGLNPYLGFLHAPENRYESLAADIQEPFRAQTEGI
IIKILNMNMIKEDDFTETEKGFYLRKNAIKTFLNIFEAELDRKSKKNTVSIKDEIYSQIIRVKQYMIMDEALIFYRWKGQ
>cas__Q7MTH7 Cas6 | cas | Type I/III crRNA processing | Porphyromonas gingivalis (strain ATCC BAA-308 / W83)
MPLSTDSLPIFLSDFTAYHFSVRFRAERAIAFERKWYFMPRFALGNALKNSEQYAYLYGQIFKPQEEDTDESKGPGNTSR
LIIRADKPSRKSLEAGEAMDLYITVVTRDPLLVGDFLSFLPEWQAYNFFRENDLTYDSYRLYNPTTQKYESGLRVEDAAL
TVDFFSRQAIRWGEILSVRFLSPASIKVDQILSAEIPYSRLMNRLSRRLYELYTQYLSRGETSVERYIFPDHDGLIYSQI
SMPRKATIKENRQYDMSGILGQLFYRVPYDPVAALMLSMAHWVHIGNHTIVGNGQIESTPGNDTLYRKWLSSLAADRDLP
MAEAERQDLLEALRICSYIPQPYHSVNIPKGDGSYRQLHIPSAVDLHLQRSLAGILYPITESLSIAQSYAYRKGKGAVAA
VRRVQHLLDSLDENHTVVRCDIDNFFDSIPVPSLLQKVQRTTEDPFLTRMLSLWMKSGVVDRKQQYARASSGIPQGSPLA
PLLSNLYLEDTDRYIAGHITTEFIRYADDLLLFLPEKVDPLNALQDLSEHLKYRKGLKLNRDFVVSSIKSSFSFLGITFC
ADGSRSMSRDKKEGLKRKITLALHRDTENFSALSETIHGMEQYYRKLLEKVDIEAIDEVAATVYATHIASLPTSEARKSA
KDNLLRLGFLSSETAKQTLREAMRQTVVSSADNFPIKKESEILREQQKRQLQERGEIFDLVVTEPGAFIGISRNHVLVRK
YGKTICKQPAAQIEQISIISDGVSLSSNVTKYCRKKNIRVIFYNATGQAYASLNGMNTILPSVMEAQMRLSEEKKREFIL
TLIKNKVRNQGKLLRYYHKYYRHDKELKEPLSNAIAELKQLEGIPIAEGSSLADFRQHAMLHEARCAQVYWRAFALLVHR
SGHEFEGREHKGAEGLVNQMLNYGYAILRSYVMKTIVLWQLNPNIGILHSTQDNKPALCFDLMEQYRAFVVDRSILALLA
KGEDVGQNSKGLLDMPTRSRIISKINERWFATEYYRSGEKLFSDIMKLQTKDVSAFCCGKVKRIKFYTPKW
>cas__A0A7C3UWE5 Cas6 | cas | Type I/III crRNA processing | candidate division WOR-3 bacterium
MRSFSPSPLSEFSWYRLSVTLVNIRSIPRVSAHPLSIIDAIIKGVNSLAFPNDRAEHFIFFHIKNRKHTFKIYQSVPVLL
EIFFIRKTGAEVNHWLATFKTYLEDPETGKNFAILSISGPEERNLSRVWEELGELATEGEICLEFLTPFPFKPEKEKERT
FIGKEGFIRSFERRFTRLFGKEVLYRSETDQFSLLPYYWHYTEIRHQPKSQPGLKYINGCVGKLYLKGTYKDFLPFLVLG
SELHTGPKLAHGQGYYLLHKESPPHFAPHFPDEKAILSVIREVVENYDSALEYLSATKDHPFDEVRYAEEIYREIKEGTY
QPTPNTAFSIKKKGSGQRIVERVSFKDLVVQEYLRKTITPVFERIFEPESIGFRKGVSREKAISLIQEAIASGYQYVIEA
DIEDFFPSVDPNILMKLIEFYLPKNDTLLKNLLCQSIRNGYQLEGKLYERNKGLAQGSPLSPILANLYLDAFDEKIRDWN
VRLVRYADDFVILTKTKKDAEVILAKSQSFLSALGLRLKREKTLIRPIKDGFRFLGIRFERSEVVVEPEEEFKRLKKPLY
ITEPYLYLSVNGDALIISRNRVVLETIPLYRISEIMVMEKSLFSTALVKKCAEFNIPLTITLNTGYYITTIKPDSKRYYE
IASRHCQRYYSLSETELLCFAKEIAVGKMKGYISLFRQRYQPGHNLIIDELLGTISRINQAGSLEEIRGLEGSMAKRIYQ
QLNPMIANPAFHIQKREREKPDPINSLLNFGYYLLFARINATLRAVGLNPYLGFLHSPSDEYESLAYDIQELFRPFIDRF
IIRILNLKVISREDFRETKDGAYLKREAVKKFIDQFEAEMVRKSEKRELSLEERIYFQVLVIKKWVLEDASLTFYGWEL
>cas__A0A2U1FKP3 Cas6 | cas | Type I/III crRNA processing | Porphyromonas loveana
MTSIVKESLPTFLSEFSAFHFRVRFEAQKAVNFNSKWYFLPRFALGNALKKSPHYAYLYSEIFKPQEDAEGGARKALLST
SRLIIRADKPFRRGFAAGEPLDLYITIVARDVSLVDDFLKFLPEWQDYNFFRESSLAYRSYQLFNPETDKYENSLRTESS
RLTIDFFLRHAPYWEDLLCIRFLSPTSVKIDQVLTDEIPYSRLMNRLSRRLYELHSAYLHAGGESKPYVYAESDNLLLAQ
VSMPRKPTIKDNRHYDMAGMLGQLFYRVPYDPVAAIMLAIAHWVHVGNHTISGNGQISASGGSTRLYDMWLSLLEKDRAI
PLEEAERDGLIASLCAQNYVPAPYRSLHIPKSDGGFRELNIPSKLDLYLQKSLAQVLYPVVDALLIPQNYAYRKGKGAVA
AIKQVEHLRRTLDDSYTIVRCDIDDFFDTIPLAALMEQLQDLTGDPLLARMVDLWMRSGTVDKKLQYRPNSLGIPQGSPL
APMLSNLYLTETDRYIARNITTEFVRYADDLLLFLPEKVHPLTCLQSLNDHLSVRKKLRLNKDFVVSDIRASFSFLGITF
RSDGGREMSREKTDAVERKIATALYRDTESFSALAETIRGMSNYYQKLVSKVDLEIVDRIATEVYASYIVSHEGTQERKR
IVEQLVRIGFLNQQAAATRLQTAVRKKATSIADLPKPKKVEDMLQEQRRGQLQKKEEVFDLVVDEPGAFVGISRNHVVVK
KFGRIISKQPAAQIEQISIVSEGVSFSSNVTKYCRKKSIRVVFYNAVGEAYATLNGMDTILPSVMESQMELDERRSRLFI
DLLVRNKIRNQGKLLRYYYKYYRKEEALERALAQAIDELKQLEAEEWGGKTLRDYRQNAMLHEARCSRIYWQVYALLVNR
AGYPFDSREHQGATDLVNQMLNYGYAILQSYVMKTIDIWQLNPNIGILHSTQDNRPALCFDLMEQYRSFVVDRSILALLS
KGEEVGQNDKGLLDMQTRTRIISKINERWFASEYYRSGEKVFSEIMKLQTRDVRDFCLGKIAHLKFYTPKW
>cas__A0A088E4A1 Cas6 | cas | Type I/III crRNA processing | Metallosphaera sedula
MHRNLALHAPPKCSYYPRLTCQFMQLMKMTFNVTPLHDVVLPPLSSKVLKYLVLSQQVLPFLEELVRSKDKQKPLFISNL
ALDGKRLYSRGEPITVKAKTRLTGSVTFPFSKEAFNVGGGRVKTVYGEYEISLKEVSVLDETPSTSTRGNLRVSFLTPAL
LCSKIYLPPFLREKYRRKKIGFSLIPTPGLVVAYGYRQYLALLGKTDSYENDIKTFKLLVMANALSRVVGYRLYPETVVI
GEDEKGRLRLTRGVKGWIEFDIVGKLKESAAKYLEVASFLGIGRSRGIGLGEVHFKMVERGENSH
>cas__Q46899 Cas7 | cas | Type I Cascade backbone | Escherichia coli (strain K12)
MSNFINIHVLISHSPSCLNRDDMNMQKDAIFGGKRRVRISSQSLKRAMRKSGYYAQNIGESSLRTIHLAQLRDVLRQKLG
ERFDQKIIDKTLALLSGKSVDEAEKISADAVTPWVVGEIAWFCEQVAKAEADNLDDKKLLKVLKEDIAAIRVNLQQGVDI
ALSGRMATSGMMTELGKVDGAMSIAHAITTHQVDSDIDWFTAVDDLQEQGSAHLGTQEFSSGVFYRYANINLAQLQENLG
GASREQALEIATHVVHMLATEVPGAKQRTYAAFNPADMVMVNFSDMPLSMANAFEKAVKAKDGFLQPSIQAFNQYWDRVA
NGYGLNGAAAQFSLSDVDPITAQVKQMPTLEQLKSWVRNNGEA
>cas__Q8U1S6 Cas7 | cas | Type I Cascade backbone | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
MVNIKEKLFVYLHDPPDKALKIENHEERSKKILSSGNIQYSRTDKVKQADALSSKTQRFIIRTKENKEPVIDFLGRSSGK
YFHVGYPVFIHPISTEIKRYETLEKYIDLGRSNRGERFVNEFLERVSKLEGDVLKEVFEDASNKFKGEESKQWAYIWQFY
PVKLKEGVKEFAKSELKLKEEEAEKFAEEFVNLPADTRFPDHAIWTHLDLTSALSVKDPTLLRIKIVPVQPFIANSRKQL
DLWASSHLLSMLMYKALEVIVDKFGPEHVIYPSLRDQPFFLKFYLGENIGDEILVANLPNKALAIVSGKEAEKIEEEIKK
RIRDFLLQLYREAVDWAVENGVVKVDRSEKDSMLKEAYLKIVREYFTVSITWVSLSEKEDIYQVTENAGLSDEDVKKWLK
FAEKKENSRVLERIAIYPLLVKILDSLGERKVTEERFEKSEQLKGWKCHVCGENLAIFGDMYDHDNLKSLWLDEEPLCPM
CLIKRYYPVWIRSKTGQKIRFESVVDVALLYKNWRKIFDEKYGKDLVSKAREVSEDFVKDNMLVDSDLYYSSTWESGLSK
KLKNKKEIDEEKVKEVVDFLNAAYKEIGNPPKYYAILVMDGDDMGKVISGEVLGEISTRIHPNIRDYVEIPEAKYYSTPQ
VHVAISQALANFSIREVRSVVKDEGLLIYAGGDDVLAILPVDKALEVAYKIRKEFGKSFENGSLLPGWKLSAGILIVHYK
HPLYDALEKARDLLNNKAKNVPGKDTLAIGLLKRSGSYYISLVGWELIRVFYNSELRKKLLEEKGGVGKRFIYHVLREVD
TWPKVGIDEMLKFEVIRHIRGRNKEETKELREKIYGEIKDLLEHVRGNNEVEKVRGLFTFLKIITDAEVFP
>cas__Q97WX0 Cas7 | cas | Type I Cascade backbone | Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)
MSTDDNSREEFLNYKIMALLHDPPNKAWVITSRAHNLTVQLRSVRARKSHERVAKYIINQLFGDINSKTVDNADKLASSI
DRYLGSIVYKEYSLFRNRSIFLKNILLSNIQRDVGNLFPKDKSKLDNLISEYKKLLNVTNTTNLNILKYQLFYLIYELIW
IDSRYENTPAETRNPTHTIFDHLYATAAMMNWIFSLEKEAKGYLLGIDTIGVADFISKGKKTRDLWISSYLVSALLWYVI
TWFIEEYGPDVILFPSLRFNQFYAFYLLEKLRKEKISEDVIDEIKELITKYIFNGDDLFEKLEIPPYPIIPGRITLILPG
LIREGEEYTQVPDDNYFISKVKERYNEGWRKLIEGLKCYSELKREDGFWNLVCRVLKLTEDLLQTTPLNIRVKQVSVTKD
EIFNNSKLRSDSWKIYDNKYRQLVSEFKKSKLVKVTPESRLKLFELTKFDKLPQIGEKSKRGYEFCTSCGVLPAVIIMPK
EDEFEKKLIELGIARDEKDVRSIKNMISPGERLCPWCLVKRALGAEPRLMRILLLGDLCSVEKIVNEIVSKDVKIEIPST
SDIASIKTFEEMIEKKNEICEDLKEEEVCEKPNESMLSMWQRFNKNYYTGINLTIDPEEYWFSEKRRRYYFSLFRRHRIT
FPSPYYALVRADSDYLGDLLEGKLTPYLAGIIDSGDYANISEKKEEVNKLLEEYLVNAGSGPIVDYVKTVLECIRGNLNK
CSCAVKIYSNEVAEVMFRANRLLRKKLEKIDVEREVENSLKYFRTILKEGRIIVTPAWHVSISSALNRGLLVELELINKH
KGFVIYAGGDDLLAMLPVDEVLDFVKESRRAFAGVSTGRLGNMCLENGFARINNAYYPSLPIVGRSYSVIIAHYADPLFF
VINDSYNLLEEGKEMIRYRVMYNGEYKDAKKDVAIFRYQGLTSVIPLSLKRPIVNSVSDFNEIASIIDLILELKKRIDEG
HISVSLLYDYEEYKHLIVASDEKYLTEFLVKDWIKRNSLRKHVEFTIDEKLYGVRLTIENYPIKIPNDLISNIVYTLRII
YGGEK
>cas__A0A080M6L2 Cas7 | cas | Type I Cascade backbone | Candidatus Accumulibacter cognatus
MIEYVLILSLGPVQGFIAAARRSRDLWSGSWLLSEISKAAARALHEGGASLIFPAPDSDLRPGSEFSVGNKVQAVVALAD
ESEVRQLAETAKEAARRRFRNIAETARDGLKAEEALRPGVWSAQIDDYVETFAAWARINQAGYGEAAERAADALAARKAT
RDFRPSAASAEDEAGFGLPKSSLDGARETVLREGRIGDRVRRKLGLSGSEQLDCAGIAKRLGGTIDQFTPFSRIAAQPWV
ATLPPEVLQALGAAYEPLVALDLATRVRGNAGCYSSLPYDGQLVYRFRLDAALRDAIGDREATAVLESLRDCLKPVWKKY
GEPCPYGAILLADGDRMGKLLGEANDKEHHIRITTTLSAFAGSVRERVREFHGHAIYAGGDDVLAFLPLERAFACAKALQ
IAFAEALQEVAGDLGVSQEAMPTLSVGLAIGHLMEPLGTLRTLATQAEKKAKGDELAECRKRNALGIALRVRSGSETSVR
LRWDDAAALADFACWQEAYRYQPGGGRKLPSRLAYDARQVHRRTAFALTGDSPERGIPAAEFARLLDRARREDGGRLDPE
IVARLEGRLEALYRDDLDLATLADELIVARWLAARTAGDLGGD
>cas__A0A096BER3 Cas7 | cas | Type I Cascade backbone | Caloranaerobacter azorensis H53214
MKEYLLLFAINPAQRYIAQARKVQDLKMGSFILSYIINKTIEELYKSVSETNVQILFPHKSIQKKPNRFVAKVKVDNPKE
LGKELEQFAKSKFKEIASYVLKEVTNNCIVKKSNPDTLEKQINTYFYVNWVFHELDNDYYSTYCEIEKLVSSVKVLNMFE
PLSEVGRKCKLCGERNIVFYRRTDSEESKGTDYIPKKLYIDELSILDSNSPQRYRFEKGEGLCAVCTVKRFGELYFQKES
CFEKENLSTAAIAVMNWLDKISIKEQEEYKSLFDSFDEQLYYEENLSEKYAEKYEYIKSENKDNLEKARNMLRNYYKKHG
RPPKYYALLVSDGDDMGHWLSGDFLIDKSQLKTFHENMSQELGRYADDIEKMINKPKGKVIYAGGDDVLAFVNLDYLLDT
MPSLRTEFPQFDKLAQVKDDIKSSVSCGVVIAHYKEPLEEVLNWARRMEKEAKQQDGKAAFSIVVLKRSGEIQKITMKWE
EDDIKPIEILKELVKELKNDKEGFSDTFIRRLEEEGRKFNQIEEYILKSELTRLLNRSCFETCKSKKRGKVEKWAKNLTN
VFRYFANYNKYGFEGFISFLKIANFLAKKVTM
>cas__A0A098TKG2 Cas7 | cas | Type I Cascade backbone | Neosynechococcus sphagnicola sy1
MSTSAANEFWQAKIWGLLHDPALKALHDDTGRGGNSFWRDLTVMQDWKSRGWNPEERDPDKQIEALRHILLSDHIASASD
RGAIGSLSHPVDYDENGLEVSHLLSEAKLPLKLTPKAHQGLLQSGRVGFLKAHEKTLFPEAIKGETDPRKVFWWLWRCLP
KAASNKFANDESLLLMPAETRLPDSSIWSHVSITSALAGSLAGYNLQISDVEDWSKDKASRPYLATFTFTPVQELIKASR
KMRDFWAGSWILHYLSAKVCWALAWKYGPDSLMYPSLFQQPLIDHWLLNGSGQFKGWKDDFGRWVTQPSNQQLLTAGFPN
VLVLVLPEGKVKAAMQMAEQTLRQEWENLSSCVFEYLKDEKHWLPKVFQAESSTWDGWLDTIWQTYWTALPIGTRDEELT
ARLVKPDASNRDQQDRDLVNWLKKQNFTCSLIQRLEDPLYGAPKTQYKSKNWLLKPNEGSFLRAAVEQSRYPHFSINVGS
WWPHVFDQARLSLTAIKNARSWELPTAFSARSSISGIGPIVHPEKCSESKDWISEGESKRFWKRHAGLFDGKEQLNATET
VKRVLPKVLQKILNLEHDVSTHYPDLTAGVAGYLKVSDRSHLDYFHKTCADIQTKLEESQLDDGDIQNSYWGIPWLGNPE
NSDFQGYHSRYLKPDWLVETSDQDEKSEIVREKIQSIKAFVNSRYGDNDPASWYVLAVGDGDGMSEWLKGILLKNYRDYI
PKKLKDYCDFESEEFKKASLEEQDLRIKFEKILDEPKRMGPSTHAALSRALLDFSNQLVPYLTEQRYAGRLIYSGGDDVL
AYTNLWEWDQWLWDVRQCFKGDQDPHNQFDDTGDYWRWKTGEPPDNVSSRPLFTMGGNASISFGIVIAHHSVPLAIALEN
LWEAEKEGAKKHKSPDGAKKDAVQVRVLYGNGNILNSTTKFDVFNQWKALLNFKQTHSHVDFDPALFEQAAEIWRQHPVP
FLQDSTDPFAAIAPWTQAFCERRELFKGEEKEQAKQDFQKALAAYLEALCLTTEAEDRDRQIQNWLKLAAFTLRKRDIKI
GGAS
>cas__A0A0A2EQH2 Cas7 | cas | Type I Cascade backbone | Porphyromonas cangingivalis
MNTNTYTAVTIGPIFKTIGKARSVKAFWTASYMFSWIMKRLIEELRGCSILSPHLPEEEPSFDTIKTKVGLFPDRLFIEG
DAKAHVERAKENIIKELTEKFNKIFDSEIGIGDIQGYISISTILVDVPDAEEGPLKILNEYLDTQELFCKSSPQGKDYME
EFMENAENGFLQGFKGKDKRPFESTSEIAVSGWLSPDMIKENLSDKSEIDYTKLTKEDGYRNCYKYLAIIEADGDNFGKY
IRKLSSSDDMRNFAKSFFNFSVDVANKLRNETKAVPVYIGGDDLKLFAPILGGDVEKDIFRIIEIIDGCFQDFLKELSAD
EKPSMSYGVSIFYHKSPMSEAMDVAIGTLDKVKKTETKDAVAISIRKHSGKKIEFQLPRKHSDATSDIRNHTLYAKSVEL
IRAFKGDVSMINSLIYWIEEMYEAIFTDSVTGNRNRIKAVFANFFDEDVHKNHRGEGGFFERLEEFIYLMHENKDAPQTQ
EGKKALLHGILRYCQFVTAKDEK
>cas__A0A0A2WNG2 Cas7 | cas | Type I Cascade backbone | Thermus filiformis
MDHLMAIALGPVQEFIATARRFRDFYAGSRLLSEAAARAARHLAQAVGPENLIFPAPKDLGELEELGQAGIPNVLLLRVP
EGKDPASLGEEALGAARGYLREMAEKTLGPHRAHLRYPEALAQVEDLLEGYYAYLPLGDYAQTRGRLMALLSARKNTRDF
APVFWGGPLYKSSLDGARESVLDFRQDEARLRRRLGIKEGEYLSGPDLLKRLWQAPPFPSSTHMAALPFWEGVRARKAEG
VLEEALEELAHLAGEEARTGNPHPALRDTPFARLDVRLLYESRLEEFPALAEDEGRLEAARSRLASLWKELRKRGVKAPP
GSYYALLLADGDRMGEAIDRQTSLQAHRELSRRLALEFAQKVRALVEGHRGGLVYSGGDDVLALLPLHTALRAAWDLAQR
FQEVMAPYGQDGVRPSLSVGLAVVHHLEPLQDALDLVRRAEKLAKSGYKGEAPRNALAVAYSPRSGSELVVRGRWDEEPR
LTQRLLRYADLLRTETVPGRAAYELVELLRMEKDLPDHEKPLLREALVAEARRILGRKQMEAGYREELSPSDWVGVKRLA
EGLLLARPFAEALEQAAVPAESLEVWRAH
>cas__A0A0E3PWZ6 Cas7 | cas | Type I Cascade backbone | Methanosarcina mazei WWM610
MNELIEKIKHYGDEFCLLRVSIGPVQEFISEARKTRDLYIGSRLLSLATFRTMKPIFDTYGLEAIIYPHIKYSKERLSSL
PNIYMAVIPKSEFHETISQMEIGLQNFWNDMQKEVNRKLPPDCKGYYNQKIKSPFYMNWVAVPIVIEELNSEYKPKVKEI
IHFFNERKVTRTFDSWEGSYIQKCNQCGRREYPQEIYSSVQEKFKARIRENEILCSICLLKRLLNPDDIDVSPQKFDSVM
DVSAAIAKKLIEQNKNEKHEIKEFTDNVKRIGNVIDNTYKNGECYYEDYLNYDFFKKEYGIPDNPDFRKLCEDTKKSLSA
AYESLGIKEPSKYYSILMMDGDNMGKLMSGEVKLTSGDILKDADFTLNYQKKLSEILADTGSNTSELIKSQEEGNGNGLC
VYSGGDDLLAFLPLETSLSTANKARSCFISEFRKSNIKQTSSAGIVILHHKDPLRRGLEEARKNVEEAKKSFKDKDAFCI
TLRLFSGSVVTWGYKWEIRTPTLQNLDSVKVLDVLRYFVSFMLESPEKKLSPSFVRDFMEELPSFYEYNERKSTWKLSEE
MFKSEFWRLLKRHMPSESNLWKVEFKKGILTLDLLAESFIYMADPEKNNQVKNTKENFENFLQIALFLVREQIGGDLK
>cas__A0A0E3S104 Cas7 | cas | Type I Cascade backbone | Methanosarcina mazei C16
MSQFLFLFTVGPVQSFIAQARKSQDLYSGSFLLSHLSDIAIYKLKTLVSSCDLIFPNKEIASKPNRFIAKIECEDPEKIG
SELHNFVQNEYRKICEDIVTKLNLNAPEGFNQQIDYLLDLHWIALDFEEGEYASKFSELESYLGAVKNIRRFHQFQEAGR
KCSLCGERNVLFYGGARKRAHVHDAERINNVSNKFISDGEGLCAVCLSKRFAGRHFKKKYHSDYPSTAEIALMDTLSKLD
SSLLNDYKSFFGKDFDEQLYFKDNLTKKYFEKNGIKADPEISLKELAKITNIAEQTGLKFSTYYALLCLDGDNMGKWLSG
KFLEDKDKSNLMDFHFDLTKKLGTYAIKVKDIVQNPKGIVVYSGGDDVLAFINLDYLLPVMKELREHFPAFEEFSYTKQG
EKSSASCGVCIAHYKTPLQEVLTWARKMEHEAKSIDDNAKKDAFAIAVLKRSGEIHKTVFNWKYETLDTIEVLAELISLL
KSPNNSETPPFSDSFVNKLNEEFNLLMNDEGNYSEFPLFETEIKRLINRSCMMVKNTGESETEYRSRKDQTIADITEKLC
ALARESRSLENFLSLLNTAVFIERGSN
>cas__A0A0F8DUJ5 Cas7 | cas | Type I Cascade backbone | Methanosarcina mazei
MSQFLFLFTVGPVQSFIAQARKSQDLYSGSFLLSHLSDIAIYKLKTLVSSCDLIFPNKEIASKPNRFIAKIECEDPEKIG
SELHNFVQNEYRKICEDIVTKLNLNAPEGFNQQIDYLLDLHWIALDFEEGEYASKFSELESYLGAVKNIRRFHQFQEAGR
KCSLCGERNVLFYGGARKRAHVHDAERINNVSNKFISDGEGLCAVCLSKRFAGRHFKKKYHSDYPSTAEIALMDTLSKLD
SSLLNDYKSFFGKDFDEQLYFKDNLTKKYFEKNGIKADPEISLKELAKITNIAEQTGLKFSTYYALLCLDGDNMGKWLSG
KFLEDKDKSNLMDFHFDLTKKLGTYAIKVKDIVQNPKGIVVYSGGDDVLAFINLDYLLPVMKELREHFPAFEEFSYTKQG
EKSSASCGVCIAHYKTPLQEVLTWARKMEHEAKSIDDNAKKDAFAIAVLKRSGEIHKTVFNWKYETLDTIEVLAELISLL
KSPNNSETPPFSDSFVNKLNEEFNLLMNDEGNYSEFPLFETEIKRLINRSCMMVKNTGESETEYRSRKDQTIADITEKLC
ALARESRSLENFLSLLNTAVFIERGSN
>cas__A0A0F8HGG4 Cas7 | cas | Type I Cascade backbone | Methanosarcina mazei
MSQFLFLFTVGPVQSFIAQARKSQDLYSGSFLLSHLSDIAIYKLKTLVSSCDLIFPNKEIASKPNRFIAKIECEDPEKIG
SELHNFVQNEYRKICEDIVTKLNLNAPEGFNQQIDYLLDLHWIALDFEEGEYASKFSELESYLGAVKNIRRFHQFQEAGR
KCSLCGERNVLFYGGARKRAHVHEAERINNVSNKFISDGEGLCAVCLSKRFAGRHFKKKYHSDYPSTAEIALMDTLSKLD
SSLLNDYKSFFGKDFDEQLYFKDNLTKKYFEKNGIKADPEISLKELAKITNIAEQTGLKFSTYYALLCLDGDNMGKWLSG
KFLEDKDKSNLMDFHFDLTKKLGTYAIKVKDIVQNPKGIVVYSGGDDVLAFINLDYLLPVMKELREHFPAFEEFSYTKQG
EKSSASCGVCIAHYKTPLQEVLTWARKMEHEAKSIDDNAKKDAFAIAVLKRSGEIHKTVFNWKYETLDTIEVLAELISLL
KSPNNSETPPFSDSFVNKLNEEFNLLMNDEGNYSEFPLFETEIKRLINRSCMMVKNTGESETEYRSRKDQTIADITEKLC
ALARESRSLENFLSLLNTAVFIERGSN
>cas__A0A0M2UWI2 Cas7 | cas | Type I Cascade backbone | Candidatus Brocadia fulgida
MKNYLLICEIGPIYDFVRQSRKTVDFWGASFLFSYVMSEVARDITNNGGTLFLPYLDNNPMYRRNGTIACGSVPDQIYVT
FTDSRRSAIENGLKTIIEEIVKTIALKVGKLAEQKGKAGVFDHGELKDFFHFFYTIHEIKDAQPTFEEFLEAERKIRIRS
ALRPFRQITGNNSIAKWEKCSLCGDRKRIYSKVVDKDAGLYNEEHICSVCLLKRFLPEAVKSIFSGTRAELKKPRYQSTS
DIAFSPIKACIDTADDEMKQAYKALIRECEQISEEKDSEGRFFYDPNLRKKFTAWKKSLTEKYQDKIKLPWLDRPFYSII
SMDGDNMGNILKENRDKFPGYIQDVSRIISDFSNAVNATVSRNQGQLIFAGGEDINFVIHPEYLLDCIGELNNLYNGYFL
KNDLTKPMAEKFTLSAGVVVCYHKYPLSQAILSACGMLRKAKKFRGKNATAISLIKGHTETFNFAFSNKLIGDLKRLKEL
LLSADISRTTPYRIKESEEVLKAITDARHKENYLYTIIAGTRGVDKANAEIMEIVGLLMKFEGIDAMINALLYARFLAGD
K
>cas__A0A0M8K4X0 Cas7 | cas | Type I Cascade backbone | Ardenticatena maritima
MSTKYLFICSIGPVQDFIAAARSSRDLTYGSHLLSELAKTAARTIADKESFDALIFPAPKSKKDLDENSALSVANKVVAV
VSGEPQGLADTIEEALRAFILNAWHPIEDKLQNDVDKALARWQLKDLLEFYWVAAPLEGKYEEVRATCEAALSARKATRD
FRRYTGKPRFKSSIDGWREHVLEQLPNTASSPTDKQMKRYKMRNGELLSGVDLLKRWGGLELSATYKSTGHMAALPFAEG
LAQNGVNVHELYQALEDLITDNDGNLFAKDDYSVFFPAEVRAAFDDKEKAKTVLEKHERLLSQYAGTRRPSPYYALLLAD
GDSMGKAIDAQTSPAAHRALSQKLSEFAQEVPKIVRQYRGVPVYAGGDDILAYLPLHTALECVRELAETFQEMMSAFTFD
ENGQQKSPTLSAGLVITHHLEPLRDALALVRAAEKSAKTVAGKNALAITLNKRSGADRTVKGNLFALIERLQTMRGWWLN
ETLSKGTAYELERLARDMEGVLPAEALAAEAVRILKRKRESGGKEKVKQEVIDQIENWLKKEQIKLHELAQEMIVANELA
RASKQAQGKEA
>cas__A0A0P6XJ69 Cas7 | cas | Type I Cascade backbone | Herpetosiphon geysericola
MSNLFLIAIGPVQDFIASARRTRDLWFGSWLLSELAKAVAKSIYEKEGKEALIFPYPTDLPQDLEPNSTFNVPNKILAKI
KDDPTGQAVLAREALIARLNEIREAAFAKVNGKIERERAIEQIDALVEFNWVALPLASDDTYRATRQQLENMMAARKNTR
NFGAVTWGTNDPKSSIDGERESVIAEKYYPPPQLSNTSPEYAKIVVDLYRNYGINVGERLSGVDMLKRHGQKGKDSRFPS
TSHMAAVPVFNYLLGMNTKEQSKNKVAESWDTYIANLNTILAMREYIRNEVTPKSQDIFEDYDGSLLFAERFNDALVGED
IQKAQQFLHTFLQPFLGTKVPIPYYAILHADGDAMGSVINKQEELIDHQDISKQLTVFAGEVKSIVEANQGALVYSGGDD
VLAFLPLHTVLECADALAKRFQTLLSNFKDKTDRSPTLSVGIAIVHHLEPLSDALELARAAEKKAKGVAGKNALAINLSK
RGGTDRIIVGSWIESTYSFYNRLKKLIEWHQNDKIPLSFAFELHDLSIRLKDLPANIFHAEAKRIIERKHTSNGIKVDGD
IAQKLLSMIHDLVPETLTEAHTLIQQFADEVIIAGFIAQAQNLSNGK
>cas__G4RJZ5 Cas8 | cas | Type I large subunit | Thermoproteus tenax (strain ATCC 35583 / DSM 2078 / JCM 9277 / NBRC 100435 / Kra 1)
MTQCPQEMITPGHGIIADALIMHGLIKILHIEGKMEGWAERRGERFVVCAERPDLNWIDQWEPMELLEIAAEFKAKGKDR
ASEEEEQRPYFGLVHDLSRSTVDPGNFSSWISDVREALYALKADFDLSEEHKEKRGEGRARSKKRGYYTLYLPLSGVYGK
YVVENYGIRQSQYAVCATCFALSTLGYIYGTVKARVERRSSSGGGHDVFNLTFIPRERTSLRSLMALQRMAGLVEMRPGD
LNELGAVVYMLSVGETIYAVREGVDILVWVTQRAGNFQRTVGVNIFRGDRLLEAIAEIKYRAPSWPKIARQLGSSLNVLG
EYLAFGGDVYHVIRSVMADLGRKGGKLAGLEGLAEALKKIG
>cas__Q57830 Cas8 | cas | Type I large subunit | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
MIIKGLRVEKEKLQSLQKFWRLRVMLFETPGYNEILDLYIAYGVVECLVREGVENLRFFPIGNKYCIVVEEPTNVNIKNR
IEKGMLNALEDMLSLHKAIGKYISTKEDIKIISDVDFSAGANINNVYWDGIPKTLEKIKENIKKGKLSTKSKNTVPLTLM
PAAGKYMPKIYGVKGGNPIKIDDSNYALAWIGFHYYAPYINISDNRATYIHIYAIKPLEELGLIEILALKDLKKKINNYQ
LGKYKFFVNKKLALLYHLTHTESISALEIVTKKNFSVVSYTLENVDNNQAIRSFGEYDLSKLMDFLWYLKATDFYNTIQF
VDNILRGDLEVSLTFIDGILYDDLDAVYSAIRKLKSVRISPLIIQSILEWFGNFY
>cas__A0A520KJ89 Cas8 | cas | Type I large subunit | Candidatus Methanodesulfokora washburnensis
MRNTTMGGYSNRGIDSMQLELHTPGHSIYTDTLMMYALAGAAGNQLEKVLGRENSYTLILNISIDELADKLYNEFNENEN
QLKSRFTRARLLSEKDIEEAKKFIENKDSLVEYLRKLHNPGHAREEGRQGGEHILKLPLMPIAGKYLRTDLTTSERYKVR
EYRVCAYCSSIAMLGLNIGLLDVSMRGTSILMTLSLEGEVERDTLVDLIDSIKQLYIELDTEGEGFLTELRNCIDNLPTR
LFGYLVLTGLDDKVILSLDESNARWRALVVRFETARAVQVRGFHSIELDSTLSSLADLIRLERKAQTNYRGPLNDLRDNL
LKNGAADAVEKLFDFLSSRDIEKLYHLARSSYTTLKRGFGSQLIEGLACLSLPQS
>cas__A0A5C0XQ46 Cas8 | cas | Type I large subunit | Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
MKFNEFKTPQIDPIFDLYVAYGYVESLIRGGAKEATLIPHGASYLIQTDVSNEEFRHGLVDALSEMLSLHIALARHSPRE
GGKLVSDADFSAGANINNVYWDSVPRNLEKVMKDLEKKRSVKGTATIPITLMPSAGKYMLKHFGVQGGNPIKVDLLNYAL
AWVGFHYYTPYIKYAKGDTTWIHIYQIAPVEEVDMISILSLKDLKMHLPHYYESNLDFLINRRLALLYHLLHSESLGALE
LFTEKEFVIHSYTLERSGNNQAIRSFEEEEIGKLMDFLWKLKRRDFYHAIKFIDDLLKKATEGALALIDAIMNERLEGFY
TALKLGKKAGVVSSREIVAALEDIICER
>cas__A0A7J3YU21 Cas8 | cas | Type I large subunit | Ignisphaera aggregans
MKLYTPGHGFFMDSLIMYGIISCLPSNVKYHVSGSAGLFEIEIEDEDIYDISNLLASYIDQHREYMIGLLIGQSKLVQKS
SQKRLETFLMKYSDPNIVAQDLEQAYTSRGHAQNEGRFHKGQHVWLPLYPHIGKYFTGEYRYPASNYGVCPLCITLAVVG
FSKAAISIPYNPRKNVSRTLVVMFSFEGEVSGETLRRMLTYIKSEYFRQVTSKLRPIINDIPSNIVICILLAGWTAETIL
YLNESRA
>cas__Q8ZZL4 Cas8 | cas | Type I large subunit | Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)
MLKEIYTPGHDVFADTLIMHGVVRHLAASGIVEGYVERLGERYKISFEGEPRALADIESVELLLFEIERYVVDGEEPVGR
LRKIFDANINISATRSWLAQLSEALVNAELSVFTLDHKAKFREGRTASRRLSTVYLTLSPIYGKYFIENRVAKENKAFGV
CHTCFAYLNIGFLYGATTIVIITRDGRRVVQLTPAPRGRISIADLALLQRLTEGYLVRSQEMPTLAYPLYWLSTGETLYA
TEESLDILVWVTEKRGNFQRVTDAMALDLSRIMEFIAEVKNKTRGWPKFVECLALEGPEILAQLTEVVLFGGDEYTVVRA
LSTSGKCAEDWRQVDILAEILFTWKLK
>cas__A0A0Q2MSL7 Cas8 | cas | Type I large subunit | Thermococcus thioreducens
MKAYPTPGIDEVFDLYVAYGYVEALVRGGAEEVTLIPEGTARGGYYTVEGNGDFEEGLASALEEMLSLHYALGNYSSREG
GKVISDADFSAGANINNAYWDSVPSRLSTVLEKIVANKKTSRRYPVPITLMPSAGKFLPKHMGIQGGNPLKIDSLSYALA
WVGFHYYAPYVRYGKGNRTWVHIYQVAPQESLGLVELLALKDLKEHFPHYYEGSMDYLSNRRLALLYHLLHTESLGAIET
VTRKSLIMRSYTLERDGNNQAIRSYGEEDIGKLMDFLWELKRRSTYYTVRFFDALLRKESEAVIAIIDAVLNDRPEGLYQ
GLRIAKRAGITPTQSVVEGMEAFMDET
>cas__A0A127B8U2 Cas8 | cas | Type I large subunit | Pyrococcus kukulkanii
MKIFKTPGIDEIFDLYVAYGYVESLIRSGASEVELVPAGGTYEVHGDADFREGLIDALREMLSMHIALARYSPKEGGKLI
SDVDFSAGANVNPSSWDSIPNHLQKIQERIKLNKPLKGIGGNRGITIPLALMPSAGKFLLKHFGVEGQNPVRAKTEEEIL
AYALAWVGFHHYTPYIRYNKGNTTWVHIYQIAPVEPIETFELLALKDLKKHLPHYYEERMGFLANRRLALLYHLLHTESL
GALEVLTSKEFVIRSYTLEKAGNNQAIRSFGEENIGKLMDFLWKLKAKSTYHTVRFLDSLLRKDSDAALTLVDAVLNDRP
EGLYMALRVARRSGVVSSRSVIEGMEAFIDET
>cas__A0A830EIY0 Cas8 | cas | Type I large subunit | Vulcanisaeta souniana JCM 11219
MPLELYTPGHNLVTDSLIMHGMVRYLVWAGARRGSVERIGERFRIIVNEDVDENKAVKELVRLQGQCRSTIEKIEAIGLF
LRKVWASNVNEPAFPAWVRSLSQSITAFKSIKTYTDINHAANSNEGRRSSRVNPTAYLPLGPIYGKYLSRDYVVKENVQY
TICPTCFLMANMGLAYGSFVLRVNKGNRISSIMVTLIPSVKADLIDIVLVQRAFEHRYNEFNLDIPILAAPLIVLSFGET
LYAFENMDALIWIYEKSGNFMRIPNYIQINIEGLLKAISDIKYHIPQWPRILNDCFLKNEDGPIILAELSEAIINNTIKD
NIYNITREIVEFLKKKETCIAHLDAIKKLVDVLAEL
>cas__A0A832Z594 Cas8 | cas | Type I large subunit | Thermococcus paralvinellae
MGFKTPSYGEILDTYIAYGFVESLLRAGIEELTLIPQGGEYIIEVNASKNTLLTG
>cas__Q9YCM8 Cas8 | cas | Type I large subunit | Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)
MVCILYTPGHNLYTDTLILYGIARLLAWSGKVSGEVERVGERYVVKVDADNCHPVSQLPESIRLALRLLQEEQQQVFLGD
EGTFYSDLYRLARGSKVGESILNNLRIRVAAKILSNDANILEKYVSPGHKKLQGEFRGRKKGLVTLVLPLGPLYGKFYTW
SLKPRRLTEKPYVVCPYCYFLSVLGFHYGSYTYQKDGESKVVTLSPHHASLEDVLALSQSFEAASIWMPAILRYRNSLTG
PGLSLYVLSLGETLLSSSSHFEVLYGEFSVDNNTFRVVDVGRLPGVLLTSIAIIKYHMASWPRLIDFIARRDPGLLHRIA
LTLSFEVGNEYALYGILREILSLLNDDKSQEARYLAKQLDRLAEGLAMVWESGG
>cas__A0A7C1T5I7 Cas8 | cas | Type I large subunit | Thermofilum pendens
METRLVTPGHSPPLDTLIALGLANGVLQACPTASLLVRKRGVCYEIRIKGQVNWEEVHAKLSDAIMFEARRLRFGMGDLL
RAFGPQRGIKFEELEGRFLDLTKKAYNHMLEVEKEYSQEAQHAASEGRVKGRRGRTAYLPIAPWAGKFFAGTYKYQKRQY
TLCPLCSFLAWAGILTSSSLIKYRKRDKRGTIYVVPDPIHMEGYDLALLSLLFREKRTYIPEDLPLLAIPLLVLSTGETI
WPVEGEYGLYVWKYEQVGNFPGIRGYSQQPLRPLLEFVAKAKSRGGRLARLVRVLSQRDPAALAQIVECLSYGEPDPYTV
VRSVWTSLNQEERRTELLKLLERSFAEALYEVWRSYWGS
>cas__A0A7C4D013 Cas8 | cas | Type I large subunit | Ignisphaera aggregans
MLRGAREMVKLYTPGHNIITDSLIMHGVLRILGVLGYHSGVVQRVGERFIIDIEGLDQHSVRDLGSKFRNTDVYHSLQLT
LNLYINKGYMPRDQKVSKIFESNPNEPANRSWATNLSESLLNLDLSNYLSSDHITSVNEGRRKGVRTLYISLSSIYGKYQ
ELDYNTIDKPYSVCDTCFGLASLGLIYGALATVLRRENSKYSLFMTIIPEDRIEIRDLLIIQRLLEGYMTMGRFSASAPS
DIPLLALPLYSLSVGETLAAIESEADVLTWKVAKVGNFIRSLDTALIRLNKLMDFITEVKMLIPEWPRIVSQCFETEDGF
TILSELTEVIVFSREISHIYSTVRSIISYIEDMKDTTCKNLLKRMHRVSEKLVETITKVVAI
>cas__A0A832SR83 Cas8 | cas | Type I large subunit | Pyrobaculum aerophilum
MLKEIYTPGHDVFADTLIMHGVVRHLAASGIVEGYVERLGERYKISFEGEPRALADIESVELLLFEIERYVVDGEEPVGR
LRKIFDANINISATRSWLAQLSEALVNAELSVFTLDHKAKFREGRTASRRLSTVYLTLSPIYGKYFIENRVAKENKAFGV
CHTCFAYLNIGFLYGATTIVIITRDGRRVVQLTPAPRGRISIADLALLQRLTEGYLVRSQEMPTLAYPLYWLSTGETLYA
TEESLDILVWVTEKRGNFQRVTDAMALDLSRIMEFIAEVKNKTRGWPKFVECLALEGPEILAQLTEVVLFGGDEYTVVRA
LSTSGKCAEDWRQVDILAEILFTWKLK
>cas__A0A832ZED8 Cas8 | cas | Type I large subunit | Thermococcus paralvinellae
MGFKTPSYGEILDTYIAYGFVESLLRAGIEELILIPQGEEYTIEVNASKDTLLTGIADALREMLSLHYALGRYSPKEGGK
VVSDADFSAGANINNVYWNGVPSKLKEILDKIESRKRLSTRQNITAPLTLIPTAGKFLPKTYGVKGGNPIKMRELDYALA
WIGFHYYAPYINISDSDSTYIHIYLPKPLEPVELIEVLSLKDLKAQKSHYHLASNKPLTNSRVALLYHLTHTETLGALET
ITKKQFTLITYTLERVGNNQAARSFGELDIAKLMDFLWNFKSANPYYALRFVDALKDDLELTLEFVDGILNEDADAVYLA
IRGLQRKNPKVVRPELMEAIARWLDKDQAFSHF
>cas__Q99ZW2 Cas9 | cas | Type II effector | Streptococcus pyogenes serotype M1
MDKKYSIGLDIGTNSVGWAVITDEYKVPSKKFKVLGNTDRHSIKKNLIGALLFDSGETAEATRLKRTARRRYTRRKNRIC
YLQEIFSNEMAKVDDSFFHRLEESFLVEEDKKHERHPIFGNIVDEVAYHEKYPTIYHLRKKLVDSTDKADLRLIYLALAH
MIKFRGHFLIEGDLNPDNSDVDKLFIQLVQTYNQLFEENPINASGVDAKAILSARLSKSRRLENLIAQLPGEKKNGLFGN
LIALSLGLTPNFKSNFDLAEDAKLQLSKDTYDDDLDNLLAQIGDQYADLFLAAKNLSDAILLSDILRVNTEITKAPLSAS
MIKRYDEHHQDLTLLKALVRQQLPEKYKEIFFDQSKNGYAGYIDGGASQEEFYKFIKPILEKMDGTEELLVKLNREDLLR
KQRTFDNGSIPHQIHLGELHAILRRQEDFYPFLKDNREKIEKILTFRIPYYVGPLARGNSRFAWMTRKSEETITPWNFEE
VVDKGASAQSFIERMTNFDKNLPNEKVLPKHSLLYEYFTVYNELTKVKYVTEGMRKPAFLSGEQKKAIVDLLFKTNRKVT
VKQLKEDYFKKIECFDSVEISGVEDRFNASLGTYHDLLKIIKDKDFLDNEENEDILEDIVLTLTLFEDREMIEERLKTYA
HLFDDKVMKQLKRRRYTGWGRLSRKLINGIRDKQSGKTILDFLKSDGFANRNFMQLIHDDSLTFKEDIQKAQVSGQGDSL
HEHIANLAGSPAIKKGILQTVKVVDELVKVMGRHKPENIVIEMARENQTTQKGQKNSRERMKRIEEGIKELGSQILKEHP
VENTQLQNEKLYLYYLQNGRDMYVDQELDINRLSDYDVDHIVPQSFLKDDSIDNKVLTRSDKNRGKSDNVPSEEVVKKMK
NYWRQLLNAKLITQRKFDNLTKAERGGLSELDKAGFIKRQLVETRQITKHVAQILDSRMNTKYDENDKLIREVKVITLKS
KLVSDFRKDFQFYKVREINNYHHAHDAYLNAVVGTALIKKYPKLESEFVYGDYKVYDVRKMIAKSEQEIGKATAKYFFYS
NIMNFFKTEITLANGEIRKRPLIETNGETGEIVWDKGRDFATVRKVLSMPQVNIVKKTEVQTGGFSKESILPKRNSDKLI
ARKKDWDPKKYGGFDSPTVAYSVLVVAKVEKGKSKKLKSVKELLGITIMERSSFEKNPIDFLEAKGYKEVKKDLIIKLPK
YSLFELENGRKRMLASAGELQKGNELALPSKYVNFLYLASHYEKLKGSPEDNEQKQLFVEQHKHYLDEIIEQISEFSKRV
ILADANLDKVLSAYNKHRDKPIREQAENIIHLFTLTNLGAPAAFKYFDTTIDRKRYTSTKEVLDATLIHQSITGLYETRI
DLSQLGGD
>cas__Q927P4 Cas9 | cas | Type II effector | Listeria innocua serovar 6a (strain ATCC BAA-680 / CLIP 11262)
MKKPYTIGLDIGTNSVGWAVLTDQYDLVKRKMKIAGDSEKKQIKKNFWGVRLFDEGQTAADRRMARTARRRIERRRNRIS
YLQGIFAEEMSKTDANFFCRLSDSFYVDNEKRNSRHPFFATIEEEVEYHKNYPTIYHLREELVNSSEKADLRLVYLALAH
IIKYRGNFLIEGALDTQNTSVDGIYKQFIQTYNQVFASGIEDGSLKKLEDNKDVAKILVEKVTRKEKLERILKLYPGEKS
AGMFAQFISLIVGSKGNFQKPFDLIEKSDIECAKDSYEEDLESLLALIGDEYAELFVAAKNAYSAVVLSSIITVAETETN
AKLSASMIERFDTHEEDLGELKAFIKLHLPKHYEEIFSNTEKHGYAGYIDGKTKQADFYKYMKMTLENIEGADYFIAKIE
KENFLRKQRTFDNGAIPHQLHLEELEAILHQQAKYYPFLKENYDKIKSLVTFRIPYFVGPLANGQSEFAWLTRKADGEIR
PWNIEEKVDFGKSAVDFIEKMTNKDTYLPKENVLPKHSLCYQKYLVYNELTKVRYINDQGKTSYFSGQEKEQIFNDLFKQ
KRKVKKKDLELFLRNMSHVESPTIEGLEDSFNSSYSTYHDLLKVGIKQEILDNPVNTEMLENIVKILTVFEDKRMIKEQL
QQFSDVLDGVVLKKLERRHYTGWGRLSAKLLMGIRDKQSHLTILDYLMNDDGLNRNLMQLINDSNLSFKSIIEKEQVTTA
DKDIQSIVADLAGSPAIKKGILQSLKIVDELVSVMGYPPQTIVVEMARENQTTGKGKNNSRPRYKSLEKAIKEFGSQILK
EHPTDNQELRNNRLYLYYLQNGKDMYTGQDLDIHNLSNYDIDHIVPQSFITDNSIDNLVLTSSAGNREKGDDVPPLEIVR
KRKVFWEKLYQGNLMSKRKFDYLTKAERGGLTEADKARFIHRQLVETRQITKNVANILHQRFNYEKDDHGNTMKQVRIVT
LKSALVSQFRKQFQLYKVRDVNDYHHAHDAYLNGVVANTLLKVYPQLEPEFVYGDYHQFDWFKANKATAKKQFYTNIMLF
FAQKDRIIDENGEILWDKKYLDTVKKVMSYRQMNIVKKTEIQKGEFSKATIKPKGNSSKLIPRKTNWDPMKYGGLDSPNM
AYAVVIEYAKGKNKLVFEKKIIRVTIMERKAFEKDEKAFLEEQGYRQPKVLAKLPKYTLYECEEGRRRMLASANEAQKGN
QQVLPNHLVTLLHHAANCEVSDGKSLDYIESNREMFAELLAHVSEFAKRYTLAEANLNKINQLFEQNKEGDIKAIAQSFV
DLMAFNAMGAPASFKFFETTIERKRYNNLKELLNSTIIYQSITGLYESRKRLDD
>cas__J3F2B0 Cas9 | cas | Type II effector | Actinomyces naeslundii (strain ATCC 12104 / DSM 43013 / CCUG 2238 / JCM 8349 / NCTC 10301 / Howell 279)
MWYASLMSAHHLRVGIDVGTHSVGLATLRVDDHGTPIELLSALSHIHDSGVGKEGKKDHDTRKKLSGIARRARRLLHHRR
TQLQQLDEVLRDLGFPIPTPGEFLDLNEQTDPYRVWRVRARLVEEKLPEELRGPAISMAVRHIARHRGWRNPYSKVESLL
SPAEESPFMKALRERILATTGEVLDDGITPGQAMAQVALTHNISMRGPEGILGKLHQSDNANEIRKICARQGVSPDVCKQ
LLRAVFKADSPRGSAVSRVAPDPLPGQGSFRRAPKCDPEFQRFRIISIVANLRISETKGENRPLTADERRHVVTFLTEDS
QADLTWVDVAEKLGVHRRDLRGTAVHTDDGERSAARPPIDATDRIMRQTKISSLKTWWEEADSEQRGAMIRYLYEDPTDS
ECAEIIAELPEEDQAKLDSLHLPAGRAAYSRESLTALSDHMLATTDDLHEARKRLFGVDDSWAPPAEAINAPVGNPSVDR
TLKIVGRYLSAVESMWGTPEVIHVEHVRDGFTSERMADERDKANRRRYNDNQEAMKKIQRDYGKEGYISRGDIVRLDALE
LQGCACLYCGTTIGYHTCQLDHIVPQAGPGSNNRRGNLVAVCERCNRSKSNTPFAVWAQKCGIPHVGVKEAIGRVRGWRK
QTPNTSSEDLTRLKKEVIARLRRTQEDPEIDERSMESVAWMANELHHRIAAAYPETTVMVYRGSITAAARKAAGIDSRIN
LIGEKGRKDRIDRRHHAVDASVVALMEASVAKTLAERSSLRGEQRLTGKEQTWKQYTGSTVGAREHFEMWRGHMLHLTEL
FNERLAEDKVYVTQNIRLRLSDGNAHTVNPSKLVSHRLGDGLTVQQIDRACTPALWCALTREKDFDEKNGLPAREDRAIR
VHGHEIKSSDYIQVFSKRKKTDSDRDETPFGAIAVRGGFVEIGPSIHHARIYRVEGKKPVYAMLRVFTHDLLSQRHGDLF
SAVIPPQSISMRCAEPKLRKAITTGNATYLGWVVVGDELEINVDSFTKYAIGRFLEDFPNTTRWRICGYDTNSKLTLKPI
VLAAEGLENPSSAVNEIVELKGWRVAINVLTKVHPTVVRRDALGRPRYSSRSNLPTSWTIE
>cas__Q03LF7 Cas9 | cas | Type II effector | Streptococcus thermophilus (strain ATCC BAA-491 / LMD-9)
MSDLVLGLDIGIGSVGVGILNKVTGEIIHKNSRIFPAAQAENNLVRRTNRQGRRLARRKKHRRVRLNRLFEESGLITDFT
KISINLNPYQLRVKGLTDELSNEELFIALKNMVKHRGISYLDDASDDGNSSVGDYAQIVKENSKQLETKTPGQIQLERYQ
TYGQLRGDFTVEKDGKKHRLINVFPTSAYRSEALRILQTQQEFNPQITDEFINRYLEILTGKRKYYHGPGNEKSRTDYGR
YRTSGETLDNIFGILIGKCTFYPDEFRAAKASYTAQEFNLLNDLNNLTVPTETKKLSKEQKNQIINYVKNEKAMGPAKLF
KYIAKLLSCDVADIKGYRIDKSGKAEIHTFEAYRKMKTLETLDIEQMDRETLDKLAYVLTLNTEREGIQEALEHEFADGS
FSQKQVDELVQFRKANSSIFGKGWHNFSVKLMMELIPELYETSEEQMTILTRLGKQKTTSSSNKTKYIDEKLLTEEIYNP
VVAKSVRQAIKIVNAAIKEYGDFDNIVIEMARETNEDDEKKAIQKIQKANKDEKDAAMLKAANQYNGKAELPHSVFHGHK
QLATKIRLWHQQGERCLYTGKTISIHDLINNSNQFEVDHILPLSITFDDSLANKVLVYATANQEKGQRTPYQALDSMDDA
WSFRELKAFVRESKTLSNKKKEYLLTEEDISKFDVRKKFIERNLVDTRYASRVVLNALQEHFRAHKIDTKVSVVRGQFTS
QLRRHWGIEKTRDTYHHHAVDALIIAASSQLNLWKKQKNTLVSYSEDQLLDIETGELISDDEYKESVFKAPYQHFVDTLK
SKEFEDSILFSYQVDSKFNRKISDATIYATRQAKVGKDKADETYVLGKIKDIYTQDGYDAFMKIYKKDKSKFLMYRHDPQ
TFEKVIEPILENYPNKQINEKGKEVPCNPFLKYKEEHGYIRKYSKKGNGPEIKSLKYYDSKLGNHIDITPKDSNNKVVLQ
SVSPWRADVYFNKTTGKYEILGLKYADLQFEKGTGTYKISQEKYNDIKKKEGVDSDSEFKFTLYKNDLLLVKDTETKEQQ
LFRFLSRTMPKQKHYVELKPYDKQKFEGGEALIKVLGNVANSGQCKKGLGKSNISIYKVRTDVLGNQHIIKNEGDKPKLD
F
>cas__C9X1G5 Cas9 | cas | Type II effector | Neisseria meningitidis serogroup C (strain 8013)
MAAFKPNSINYILGLDIGIASVGWAMVEIDEEENPIRLIDLGVRVFERAEVPKTGDSLAMARRLARSVRRLTRRRAHRLL
RTRRLLKREGVLQAANFDENGLIKSLPNTPWQLRAAALDRKLTPLEWSAVLLHLIKHRGYLSQRKNEGETADKELGALLK
GVAGNAHALQTGDFRTPAELALNKFEKESGHIRNQRSDYSHTFSRKDLQAELILLFEKQKEFGNPHVSGGLKEGIETLLM
TQRPALSGDAVQKMLGHCTFEPAEPKAAKNTYTAERFIWLTKLNNLRILEQGSERPLTDTERATLMDEPYRKSKLTYAQA
RKLLGLEDTAFFKGLRYGKDNAEASTLMEMKAYHAISRALEKEGLKDKKSPLNLSPELQDEIGTAFSLFKTDEDITGRLK
DRIQPEILEALLKHISFDKFVQISLKALRRIVPLMEQGKRYDEACAEIYGDHYGKKNTEEKIYLPPIPADEIRNPVVLRA
LSQARKVINGVVRRYGSPARIHIETAREVGKSFKDRKEIEKRQEENRKDREKAAAKFREYFPNFVGEPKSKDILKLRLYE
QQHGKCLYSGKEINLGRLNEKGYVEIDHALPFSRTWDDSFNNKVLVLGSENQNKGNQTPYEYFNGKDNSREWQEFKARVE
TSRFPRSKKQRILLQKFDEDGFKERNLNDTRYVNRFLCQFVADRMRLTGKGKKRVFASNGQITNLLRGFWGLRKVRAEND
RHHALDAVVVACSTVAMQQKITRFVRYKEMNAFDGKTIDKETGEVLHQKTHFPQPWEFFAQEVMIRVFGKPDGKPEFEEA
DTLEKLRTLLAEKLSSRPEAVHEYVTPLFVSRAPNRKMSGQGHMETVKSAKRLDEGVSVLRVPLTQLKLKDLEKMVNRER
EPKLYEALKARLEAHKDDPAKAFAEPFYKYDKAGNRTQQVKAVRVEQVQKTGVWVRNHNGIADNATMVRVDVFEKGDKYY
LVPIYSWQVAKGILPDRAVVQGKDEEDWQLIDDSFNFKFSLHPNDLVEVITKKARMFGYFASCHRGTGNINIRIHDLDHK
IGKNGILEGIGVKTALSFQKYQIDELGKEIRPCRLKKRPPVR
>cas__Q8DTE3 Cas9 | cas | Type II effector | Streptococcus mutans serotype c (strain ATCC 700610 / UA159)
MKKPYSIGLDIGTNSVGWAVVTDDYKVPAKKMKVLGNTDKSHIEKNLLGALLFDSGNTAEDRRLKRTARRRYTRRRNRIL
YLQEIFSEEMGKVDDSFFHRLEDSFLVTEDKRGERHPIFGNLEEEVKYHENFPTIYHLRQYLADNPEKVDLRLVYLALAH
IIKFRGHFLIEGKFDTRNNDVQRLFQEFLAVYDNTFENSSLQEQNVQVEEILTDKISKSAKKDRVLKLFPNEKSNGRFAE
FLKLIVGNQADFKKHFELEEKAPLQFSKDTYEEELEVLLAQIGDNYAELFLSAKKLYDSILLSGILTVTDVGTKAPLSAS
MIQRYNEHQMDLAQLKQFIRQKLSDKYNEVFSDVSKDGYAGYIDGKTNQEAFYKYLKGLLNKIEGSGYFLDKIEREDFLR
KQRTFDNGSIPHQIHLQEMRAIIRRQAEFYPFLADNQDRIEKLLTFRIPYYVGPLARGKSDFAWLSRKSADKITPWNFDE
IVDKESSAEAFINRMTNYDLYLPNQKVLPKHSLLYEKFTVYNELTKVKYKTEQGKTAFFDANMKQEIFDGVFKVYRKVTK
DKLMDFLEKEFDEFRIVDLTGLDKENKVFNASYGTYHDLCKILDKDFLDNSKNEKILEDIVLTLTLFEDREMIRKRLENY
SDLLTKEQVKKLERRHYTGWGRLSAELIHGIRNKESRKTILDYLIDDGNSNRNFMQLINDDALSFKEEIAKAQVIGETDN
LNQVVSDIAGSPAIKKGILQSLKIVDELVKIMGHQPENIVVEMARENQFTNQGRRNSQQRLKGLTDSIKEFGSQILKEHP
VENSQLQNDRLFLYYLQNGRDMYTGEELDIDYLSQYDIDHIIPQAFIKDNSIDNRVLTSSKENRGKSDDVPSKDVVRKMK
SYWSKLLSAKLITQRKFDNLTKAERGGLTDDDKAGFIKRQLVETRQITKHVARILDERFNTETDENNKKIRQVKIVTLKS
NLVSNFRKEFELYKVREINDYHHAHDAYLNAVIGKALLGVYPQLEPEFVYGDYPHFHGHKENKATAKKFFYSNIMNFFKK
DDVRTDKNGEIIWKKDEHISNIKKVLSYPQVNIVKKVEEQTGGFSKESILPKGNSDKLIPRKTKKFYWDTKKYGGFDSPI
VAYSILVIADIEKGKSKKLKTVKALVGVTIMEKMTFERDPVAFLERKGYRNVQEENIIKLPKYSLFKLENGRKRLLASAR
ELQKGNEIVLPNHLGTLLYHAKNIHKVDEPKHLDYVDKHKDEFKELLDVVSNFSKKYTLAEGNLEKIKELYAQNNGEDLK
ELASSFINLLTFTAIGAPATFKFFDKNIDRKRYTSTTEILNATLIHQSITGLYETRIDLNKLGGD
>cas__Q9CLT2 Cas9 | cas | Type II effector | Pasteurella multocida (strain Pm70)
MQTTNLSYILGLDLGIASVGWAVVEINENEDPIGLIDVGVRIFERAEVPKTGESLALSRRLARSTRRLIRRRAHRLLLAK
RFLKREGILSTIDLEKGLPNQAWELRVAGLERRLSAIEWGAVLLHLIKHRGYLSKRKNESQTNNKELGALLSGVAQNHQL
LQSDDYRTPAELALKKFAKEEGHIRNQRGAYTHTFNRLDLLAELNLLFAQQHQFGNPHCKEHIQQYMTELLMWQKPALSG
EAILKMLGKCTHEKNEFKAAKHTYSAERFVWLTKLNNLRILEDGAERALNEEERQLLINHPYEKSKLTYAQVRKLLGLSE
QAIFKHLRYSKENAESATFMELKAWHAIRKALENQGLKDTWQDLAKKPDLLDEIGTAFSLYKTDEDIQQYLTNKVPNSVI
NALLVSLNFDKFIELSLKSLRKILPLMEQGKRYDQACREIYGHHYGEANQKTSQLLPAIPAQEIRNPVVLRTLSQARKVI
NAIIRQYGSPARVHIETGRELGKSFKERREIQKQQEDNRTKRESAVQKFKELFSDFSSEPKSKDILKFRLYEQQHGKCLY
SGKEINIHRLNEKGYVEIDHALPFSRTWDDSFNNKVLVLASENQNKGNQTPYEWLQGKINSERWKNFVALVLGSQCSAAK
KQRLLTQVIDDNKFIDRNLNDTRYIARFLSNYIQENLLLVGKNKKNVFTPNGQITALLRSRWGLIKARENNNRHHALDAI
VVACATPSMQQKITRFIRFKEVHPYKIENRYEMVDQESGEIISPHFPEPWAYFRQEVNIRVFDNHPDTVLKEMLPDRPQA
NHQFVQPLFVSRAPTRKMSGQGHMETIKSAKRLAEGISVLRIPLTQLKPNLLENMVNKEREPALYAGLKARLAEFNQDPA
KAFATPFYKQGGQQVKAIRVEQVQKSGVLVRENNGVADNASIVRTDVFIKNNKFFLVPIYTWQVAKGILPNKAIVAHKNE
DEWEEMDEGAKFKFSLFPNDLVELKTKKEYFFGYYIGLDRATGNISLKEHDGEISKGKDGVYRVGVKLALSFEKYQVDEL
GKNRQICRPQQRQPVR
>cas__Q0P897 Cas9 | cas | Type II effector | Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
MARILAFDIGISSIGWAFSENDELKDCGVRIFTKVENPKTGESLALPRRLARSARKRLARRKARLNHLKHLIANEFKLNY
EDYQSFDESLAKAYKGSLISPYELRFRALNELLSKQDFARVILHIAKRRGYDDIKNSDDKEKGAILKAIKQNEEKLANYQ
SVGEYLYKEYFQKFKENSKEFTNVRNKKESYERCIAQSFLKDELKLIFKKQREFGFSFSKKFEEEVLSVAFYKRALKDFS
HLVGNCSFFTDEKRAPKNSPLAFMFVALTRIINLLNNLKNTEGILYTKDDLNALLNEVLKNGTLTYKQTKKLLGLSDDYE
FKGEKGTYFIEFKKYKEFIKALGEHNLSQDDLNEIAKDITLIKDEIKLKKALAKYDLNQNQIDSLSKLEFKDHLNISFKA
LKLVTPLMLEGKKYDEACNELNLKVAINEDKKDFLPAFNETYYKDEVTNPVVLRAIKEYRKVLNALLKKYGKVHKINIEL
AREVGKNHSQRAKIEKEQNENYKAKKDAELECEKLGLKINSKNILKLRLFKEQKEFCAYSGEKIKISDLQDEKMLEIDHI
YPYSRSFDDSYMNKVLVFTKQNQEKLNQTPFEAFGNDSAKWQKIEVLAKNLPTKKQKRILDKNYKDKEQKNFKDRNLNDT
RYIARLVLNYTKDYLDFLPLSDDENTKLNDTQKGSKVHVEAKSGMLTSALRHTWGFSAKDRNNHLHHAIDAVIIAYANNS
IVKAFSDFKKEQESNSAELYAKKISELDYKNKRKFFEPFSGFRQKVLDKIDEIFVSKPERKKPSGALHEETFRKEEEFYQ
SYGGKEGVLKALELGKIRKVNGKIVKNGDMFRVDIFKHKKTNKFYAVPIYTMDFALKVLPNKAVARSKKGEIKDWILMDE
NYEFCFSLYKDSLILIQTKDMQEPEFVYYNAFTSSTVSLIVSKHDNKFETLSKNQKILFKNANEKEVIAKSIGIQNLKVF
EKYIVSALGEVTKAEFRQREDFKK
>cas__A1IQ68 Cas9 | cas | Type II effector | Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491)
MAAFKPNPINYILGLDIGIASVGWAMVEIDEDENPICLIDLGVRVFERAEVPKTGDSLAMARRLARSVRRLTRRRAHRLL
RARRLLKREGVLQAADFDENGLIKSLPNTPWQLRAAALDRKLTPLEWSAVLLHLIKHRGYLSQRKNEGETADKELGALLK
GVADNAHALQTGDFRTPAELALNKFEKESGHIRNQRGDYSHTFSRKDLQAELILLFEKQKEFGNPHVSGGLKEGIETLLM
TQRPALSGDAVQKMLGHCTFEPAEPKAAKNTYTAERFIWLTKLNNLRILEQGSERPLTDTERATLMDEPYRKSKLTYAQA
RKLLGLEDTAFFKGLRYGKDNAEASTLMEMKAYHAISRALEKEGLKDKKSPLNLSPELQDEIGTAFSLFKTDEDITGRLK
DRIQPEILEALLKHISFDKFVQISLKALRRIVPLMEQGKRYDEACAEIYGDHYGKKNTEEKIYLPPIPADEIRNPVVLRA
LSQARKVINGVVRRYGSPARIHIETAREVGKSFKDRKEIEKRQEENRKDREKAAAKFREYFPNFVGEPKSKDILKLRLYE
QQHGKCLYSGKEINLGRLNEKGYVEIDHALPFSRTWDDSFNNKVLVLGSENQNKGNQTPYEYFNGKDNSREWQEFKARVE
TSRFPRSKKQRILLQKFDEDGFKERNLNDTRYVNRFLCQFVADRMRLTGKGKKRVFASNGQITNLLRGFWGLRKVRAEND
RHHALDAVVVACSTVAMQQKITRFVRYKEMNAFDGKTIDKETGEVLHQKTHFPQPWEFFAQEVMIRVFGKPDGKPEFEEA
DTPEKLRTLLAEKLSSRPEAVHEYVTPLFVSRAPNRKMSGQGHMETVKSAKRLDEGVSVLRVPLTQLKLKDLEKMVNRER
EPKLYEALKARLEAHKDDPAKAFAEPFYKYDKAGNRTQQVKAVRVEQVQKTGVWVRNHNGIADNATMVRVDVFEKGDKYY
LVPIYSWQVAKGILPDRAVVQGKDEEDWQLIDDSFNFKFSLHPNDLVEVITKKARMFGYFASCHRGTGNINIRIHDLDHK
IGKNGILEGIGVKTALSFQKYQIDELGKEIRPCRLKKRPPVR
>cas__Q6NKI3 Cas9 | cas | Type II effector | Corynebacterium diphtheriae (strain ATCC 700971 / NCTC 13129 / Biotype gravis)
MKYHVGIDVGTFSVGLAAIEVDDAGMPIKTLSLVSHIHDSGLDPDEIKSAVTRLASSGIARRTRRLYRRKRRRLQQLDKF
IQRQGWPVIELEDYSDPLYPWKVRAELAASYIADEKERGEKLSVALRHIARHRGWRNPYAKVSSLYLPDGPSDAFKAIRE
EIKRASGQPVPETATVGQMVTLCELGTLKLRGEGGVLSARLQQSDYAREIQEICRMQEIGQELYRKIIDVVFAAESPKGS
ASSRVGKDPLQPGKNRALKASDAFQRYRIAALIGNLRVRVDGEKRILSVEEKNLVFDHLVNLTPKKEPEWVTIAEILGID
RGQLIGTATMTDDGERAGARPPTHDTNRSIVNSRIAPLVDWWKTASALEQHAMVKALSNAEVDDFDSPEGAKVQAFFADL
DDDVHAKLDSLHLPVGRAAYSEDTLVRLTRRMLSDGVDLYTARLQEFGIEPSWTPPTPRIGEPVGNPAVDRVLKTVSRWL
ESATKTWGAPERVIIEHVREGFVTEKRAREMDGDMRRRAARNAKLFQEMQEKLNVQGKPSRADLWRYQSVQRQNCQCAYC
GSPITFSNSEMDHIVPRAGQGSTNTRENLVAVCHRCNQSKGNTPFAIWAKNTSIEGVSVKEAVERTRHWVTDTGMRSTDF
KKFTKAVVERFQRATMDEEIDARSMESVAWMANELRSRVAQHFASHGTTVRVYRGSLTAEARRASGISGKLKFFDGVGKS
RLDRRHHAIDAAVIAFTSDYVAETLAVRSNLKQSQAHRQEAPQWREFTGKDAEHRAAWRVWCQKMEKLSALLTEDLRDDR
VVVMSNVRLRLGNGSAHKETIGKLSKVKLSSQLSVSDIDKASSEALWCALTREPGFDPKEGLPANPERHIRVNGTHVYAG
DNIGLFPVSAGSIALRGGYAELGSSFHHARVYKITSGKKPAFAMLRVYTIDLLPYRNQDLFSVELKPQTMSMRQAEKKLR
DALATGNAEYLGWLVVDDELVVDTSKIATDQVKAVEAELGTIRRWRVDGFFSPSKLRLRPLQMSKEGIKKESAPELSKII
DRPGWLPAVNKLFSDGNVTVVRRDSLGRVRLESTAHLPVTWKVQ
>cas__A0A096CIC5 Cas9 | cas | Type II effector | Prevotella bivia DNF00320
MKNILGLDLGTNSIGWAKISIDDNGKYIKDSIKLGSRIIPMSQDVLSNFSKGVTLSQTSERTSFRGARRLRERTLLRRER
LHRILHLLGFLPKHYEKAIGWDRNDNKTYGKFINHAEPKLAWCKDNNGKMRFLFMDSFHDMLSEFSEKHPELLANGKKIP
LDWTIYYLRKKALYKAITKEELAWILLNFNQKRGYYQLRGEEDRDSEANKKEYLELKVIGVEATGEKKGNDIWYNIHLEN
GWIYRRSSKNPLNDWLGKVKSFIVTTDLDADGNPKKDKDGNIKRSFRAPSEGDWTLIKKRTESLLENSGQTVGQFIYNHI
LEEPSAKIRGNFIRTIERKYYKDELKAILEKQKEFHHELSSESLLTECAKELYKRNIAHQEVLLKKGMIHLLLNDILFYQ
RPLKIKKSLIDNCPYENYKYVDKKSGDIKVKSIKCIAKSNPFFQEFRLWQFVSNLRLYRKSDDKDVTSEHLVTTDDYANL
FTYLNNRKDIKQSVLLKEYFKIKKVKTINGAEYPVRWNYIDDDNKTYPCNETRYDILHALSKTELKSEWLTPERTYRLWH
LLYSIESKEETKKALNKLNLSDDFTEAFLTIKPFKKEYGSYSEKAIKKLLSLMRMGYLWSEDEAIKQVGAEIEKTIEGEL
PDYVLQRLEKSQHNYNKISDFSGLPLWLASYIIYGRHSEAKEIIHWDNPESMMAYIKDFRQHSMRNPIVEQCVLETLRTV
HDIWKEIGHIDEIHIELGREMKSTSEQRKAITQNVLHNQNTNIRIKLLLQELKNDNNITGVRPYSPMQQEILRIYEEGAL
QGLTKEDKDYNDILKISQTAQPTSNELTRYKLWLEQKYRSPYTGKAISLSKLFTSAYQIEHVIPQSRYFDDSLSNKVICE
SEVNTLKKAMLGMEFIKTCGGQKVHCTLLGDVEIYNEEDYKAFVNEHYSNNRTKRNKLLMEDIPQEFINRQLNDSRYISK
MVKQLLSAIVRGQEEVEATSKFVIPCTGGITDRLKKDWGLNDIWNNLVSPRFQRMNALTGSEYFGHWENKEGKRVFQTTM
PIQLQQGFSKKRIDHRHHAMDALVIACASRNIISYLNNETAQDTERRRDLRQKLCDKGGSVRKPWDSFTQDTQYALKDII
VTFKNYVRIINKATNYYEHYKTDGKKGMISQKGDELWAIRKPMHKETVFGKVNLRRPKRVSLSKAIDSVDVICNRKLKKY
IKARLNEGLQKKQILNIFKEVNNVWEGIDVNKIDIWEMSNDKEPMVATRKQLDTSFDEKKIRSISDTGIQKILLNYLITK
NNNPELAFTPEGIQEMNSNISEYNDHKKHQPIYKVRVTEPLGAKYPIGTMGNNPKKFVEAQAGTNLYFAIYEDKEGNRNY
DTIPLNIAAERLNQQLSPVPETNENNTPLKFYLSPNDLVYVPSEEERHSGNNIQLDKNRIYKMVSSTSKQCFFIHHRVAI
SLVDKKEFSAQNKMERSIDNEQVMIKSVCWKLITDRLGNIIKVIK
>cas__A0A134B2X0 Cas9 | cas | Type II effector | Prevotella amnii
MKNVLGLDLGSNSVGWALVKTEDNGNPIGSIKMGSRIIPMSQDILGSFEKGDTVSQTAQRTLYRGKRRLTERHVLRRERL
CRVLHIMNFLPDHFDKLLGWDKTDNKTYGKFIDDSEPKLAWRQNKNEKEKMEFVFMDSFHEMLSDFAKHQPQLIANGKKV
PLDWTIYYLRKKALTQLISKEELAWILLNFNKKRGYYQLRGEEEEEQPTKKEEYKVLKVISVDADEGQKGNGIWYNIHLE
DGGIYKRKSDIPLYDWVGKTLQLIVVTIYEKDGKTPKIFDSGKQNPSYRLPKEDDWGLIKKRTESQIQSSGKTVGAFIYD
NILSKPADKIRGNLVRTIERKYYKKELIEILQQQAKYHDELHNQHLLESCAKELYAHNDVRYNEVVKSNMIHLLVDDIIF
YQRPLKSKKSLIDNCKYESYEYVDKETGEVKEMPIKCIAKSNPYYQEFRLWQFIHNLRLSDVVTREDVTAQYLSTPQDYC
NLFTYLNDRKEIKQDILLKDFFQIKKVQIDKEKVFPIEWNYIKDATKTYPCNETKYELLSALKRAGMDKQWLDDTPNMQY
RLWHLLYSVEEKEESAKALRKLYDDDNFVSSFLKIKPFEKCYGAYSEKAIKRLLTLMRMGKAWDEQAIDAKTLKCIQQII
TGNIDSKLKEKIDDSRYVLHHVSDFQGLPTYLASYVIYGRHSEVTDIRCWDTPKDLLKFICGFPQHSLRNPIVEQVILET
LRVVYDIWKAEKHIDEIHVEVAREMKLTAQQRNEANLRNLNNEATNLRIKYLLEELKNDTFIKDVRPLSPMHQEKMRIYE
QAVLGNLNKQDKDYDDIIKISKKERPTSAELIRYKLWLEQKYCSPYTGKAISLSKLFTTAYQIEHVIPQSRYFDNSFNNK
VICESEVNKEKDKMLGYEFIKGRGGDRIYCTAHGKEVTILKEEEYKQFVNEHYAHNKRKRDNLLAENIPESFSSRQLNDT
RYITKTIMSLLSNVVRQQGEEEATAKNLLPSSGAVTDKLKNDWGLKDVWNTIVTPRFERLNKLSGTNDFGEMKEENGNRY
FQTNVPSEYEKGFKKKRIDHRHHAMDALVIACTTRNMVNYISNVNANSPKQREDLRQLLCDKNRIINKPWNTFTQDALKA
LNDIVVSFKNNVRIINRATNRYQRYDKNGKKMICSQKGNDMWAIRKSMHKETVFGRVNLIRKEALPIAKALDNISAICNA
QLRAYVNDLVDKHFNKKQLVAHFKSLDYKWNRQDVSKVEVWISSDDKTPMVAVRKPLDTSFDKKKIASITDTGIQAILLN
YLESKGGDALVAFAPEGIQEMNSNIELYNNGKAHKPIKNVRLSETLGAKYQVGERGAKTKKYVVADKGTNLFFAIYEDEE
GKRYYYSVPLREAIERQKQKLSPVPEYNEKGVALKFYLSPNDLVYVPTEEERTMGTCHIDKTRIYKMVSSSENRCCFVPS
TIAKVIADKVELLSHNKIEKAITGESIKEVCWKLKVDRLGNILNVIK
>cas__A0A1B8ZVU5 Cas9 | cas | Type II effector | Chryseobacterium arthrosphaerae
MKTILGLDLGTNSIGWALIKQNFENKYGEILGMGSRIIPMSQDILGEFGKGNSVSQTAARTDYRATRRLRERFLLRRERL
HRVLNVLNFLPEHYASQIDFDKRFGKFKVETEPKLAWKNIDGKFSFLFQTSFNEMLEDFKAHGQDLKVPYDWTIYYLRKK
ALSQKIEKEELVWILLNFNQKRGYYQLRGEEEEENPNKLIEFYSLKIIDVLADEPQKGKSDIWYSLVLENGWIYRRSSKT
SLLDWKDKIRDFIVTTDLNDDGSVKTDKEGNEKRSFRAPGENDWTLVKTKTEQEIDRSRKTVGNYIYETLLQNPKQKIKG
KLVRTIERKFYKEELKRILEKQKEFHRELESNDLYNDCIRELYRNNEAHQLTLSKKDFVHLFMEDIIFYQRPLKSQKSSI
SNCTLEFRKYKDENGIEHTQFLKAIPKSNPYYQEFRIWQWIFNLNIYKKDNDDNVTKEFLNTTRDFENLFEFLNNRKEIE
QKPLLKFLLEQKEFKGKLLNAETEKFRWNYVEDKKYPCNETRTMISERLKKVENISDDFLTREMEQKIWHIIYSVNDKTE
YEKALKSFAEKNNLDENSLFEAFKKLPPFKSEYGSFSEKAIKKLLPLMRLGKYWSYAKIDLYSKNRIQKIITGEFDENIK
DRVREKAIRLTAENDFQGLQLWLAQYIVYGRHSEASMIGKWNSADDLEEFLKEFKQHSLRNPIVEQVITETLRIVKDIWL
KYGNGAKDFFNEIHIELGREMKQTKDERANATKTITENENTNLRIKALLAEMMNDHSVENVRPYSPMQQEILKIYEDGIL
KSDIEIDDDILKISKTAQPSSSDLKRYKLWLEQKYKSPYTGQIIPLNKLFTPEYEIEHIIPQSRYFDDSFSNKIICESAV
NKLKDNYIGLGFIKQFGGTIIECGFGKRVKVFEVGEYEEFVKKHYANNRGKRNKLLLEEIPEKMIERQMNDTRHISKYIS
GILSHIVRVEDGTDEGVNSKNVIPGNGKITTQLRQDWGLNDVWNELILPRFERMNQLTNSTDFTSWNENHQKYLPTVPVE
FSKGFSKKRIDHRHHALDALVIACATKDHVNLLNNQSAKSATKRYDLKKKLMKFEKTVYKDPQTEKRIEREVPKHFLKPW
ETFTVDAKNRLETIIVSFKQNLRVINKATNYYEKYVEKDGVMMKERVEQTGTNWAIRKPMHKETVSGKIDLPWVKVPKGK
ILTATRKSLDTSFDLKAIASITDTGIQKILKNYLEFKESPELAFSPEGIEDMNKNIEKYNGGRPHQPISKVRVFELGSKF
QVGQTGNKKDKYVEAAKGTNLFFAIYEDKKGKRSYETIPLNEVIERQKQGLSVVDLKNVNDFFLCPNDLVYIPSGDEFEN
RGSIEIENITKEKSERFYKVVSFSGSQIFFVRHDIAVSIVNKGEFSTLNKMERAIDGSMVKEICIKLKIDRLGDVLKA
>cas__A0A1G6UQK2 Cas9 | cas | Type II effector | Mucilaginibacter pineti
MKTILGLDLGTNSIGWALIKQDFENKEGSILGLGSRIIPMSQDILGDFDKGNSISQTAERTRLRSMRRLRERHLLRRERL
HRVLNVLGFLPQHYAAKIDFDKRLGKFLPETETKFVYDSNGEFLFKRSFEEMLAEFKQHQPELLNRKNKKGESAKIQYDW
TVYYLRKKALTKEIEKEELAWLLLHFNQKRGYYQLRGEETEEKPNKLEEFYSLRIAQVTADEPQRGSNKIWYNIILENGW
VYRRESNQALFDWKDKVRDFIVTTDLNEDGSIKKDKEGNEKRSFRSPKEDDWKLLKKKTESEIDRSKKTVGEFIYDTLLQ
KPDQKIKGKLIRTIERKFYKEELIRILKKQIELNSNLKDTYLYKQCVEELYPHNLQHQSTLLSKDFLHLFIEDILYYQRP
LRSQKSTISNCPLERRTFILDGIKKIEPLKCISKSHPLYQEFRLWQWISNLRIINKDNDWDETAKNLELTGGVETLFDFL
TQRKEIDQKALLKYFKLKETTYRWNYVEDKSYPCNETHTMIAGRLAKVKGIPQEFLTKEKEEELWHVIYSVTDKLEYEKA
LKSFAVKKGLDIESFFDAFRKFPPFPANYGSYSAKAIKKLLPLMRMGEYWDWDKIDKQTKERIGKFIDGEFDEQIKEKVR
EKIGKQALVSESDYQGLPEWLAKYVVYDRHSEHSEAGKWNTVTNLEEYLRLFRQHSLKNPIVEQVMMETLRTVKDIWNYY
GNGVENFFDEIHIELGREMKNTKSDRERISKQNVINENTNLRVKALLIELLNDNDIENVRPYSPMQQDILKIYEDAVLND
SIEIPEDIEKISKLAQPTSSQLQRYKLWLEQKYRSPYTGAIIPLNKLFTPAYEIEHIIPQSRYYDDSFNNKVICEAAVNK
LKDNQTGLEFIQNHHGQIVELGMRETTKIFTEDEYTDFIKQHYAKSRAKKNNLMALDIPEKMIERQLNDTRYISKFIMQT
LSNIVRTEKDDDGGNSKNVLASNGKITSDLKRDWGMDAIWNDLILPRFERLNNISNSTNFTTYNDRYQKYLPVVPFELQK
GFQKKRIDHRHHAMDALIIACATRSHINFMNNKNALDKKKSSAQKQNERFDLKKILCDKKYNSSSSENYEWVFKQPWGTF
VPDAKEKLEQVIISFKQNLRVINKTVNQHDILKDGKKESFKQHKGQNWAVRKPLHKDTVSGLISLRKKKMASISIALDTP
ENIVDKLLKHRIQKFIAEGNDKKMIIKHFKENDHQFNGQDINKIEVYHWENDNVASRTSLDISFNKAKIESITDTGIQKI
LFKHLNHYNDSPEIAFTPEGIEQMNKNIVDLNNGKLHQPILKVRTYEARGNKFAVGQTGNKKSKYVEAAKGTNLFFAIYV
DVNGKRSYETVPLNIVIERQKEGLSSVPETNEAGQKLLMHLCPNDLVYLPTEEEGEFGIPLNFDKLDKEAVNRVYKTVSF
STYQCFFIKHDVATSIVNKIEFSALNKMEKSVEGKMIKDCCVKLKIDRLGNISPA
>cas__A0A1M6NSB0 Cas9 | cas | Type II effector | Aequorivita viscosa
MKRVLGLDLGTNSIGWALIKHNFGTKEGEINDMGVRIIPMSADILGKFDAGQSHSKTAERTGYRGVRRLYQRDNLRRERL
HRVLNILGFLPEHYAEHIDFKKRLGQFKDGKEINLNYKPNANGKYEFIFKSSYHEMLVEFKNSQPDLFYIKSNGKETKIP
YDWTLYYLRKKALSQPLTKQELAWIILNFNQKRGYYQLRGEEIDDDKTKQFVQLKVREVIDSGEFVKGKPLFDVIFENGW
KYDKQVVKTEDWIDRTKEFIVTTKTLKNGDIKRTYKAVDSEKDWAAIKAKTEQDIERSNKTVGEFIYEALIDNPTQKIRG
KLVKTIERKFYKEELEKILTKQIELQPQLFTTNLYEACIKELYPRNEAHQNAIKNRDFLYLLMDDIIFYQRPLKSQKSNI
SGCQFEHQIYLKTNKETGKKEKVNQAVKAIPKSHPLFQEFRTWQWLQNLKVYNKVDTDKGELTDATKQLLPNEESWVDLY
DFLQHKKELDQSQFIKYFIEKKLINKTEKDYYRWNYVEDKKYPFAETKAQFISRLTKVEGIDDINTFLDKKTQLGNKDNS
PFVSRIEQLWHIIYSVSDINEYKSALEKFALKHNINKESFVDNFIKFPPFKSEYGSYSKKALNKLLPLMRRGKYWNENDI
SDIVKKRVSEIMERVNAINLKEGYSAKELAEALVDVSDDDVKKQLIKSFIPFKYKNPLKGLNTYQATYLVYGRHSEVGDI
QNWKSPEDIDTYLKNFKQHSLRNPIVEQVVTETLRVVRDIWKHHGKSKPNFFNEIHVELGREMKNPAGKREQISKRNTEN
ENTNHRIREVLKELMNDASIQGDVRDYSPSQQDLLKIYEEGVYQNPKVDYSKVSEDEIAKIRRSNSPTQKEIQRYRLWLE
QGYISPYTGKPIPLSKLFTHEYQIEHIIPQSRYFDNSLSNKIICESAVNEDKDNKTAFEYLKDKSGSVINGHKLLSLAEY
EAHVAQYFKNNRQKLKNLLSEDIPEGFINRQLNDSRYISKLIKGLLSNIVRDEGEQEATSKNLIPVTGSVSSKLKNDWGL
NDKWNELILPRFERLNQLTQTNDFTTTNTNGNTIPTVPDDLLKGFSKKRIDHRHHVLDALVVACCTRNHGHYLSALNAEK
ENYSLRNKLLIVNEQGDYTKAFQMPWQGFTTEAKNQLEKTVVSFKQNLRVINKANNKFWSYKDENGKLNLDKSGKPVKKL
RKQTKGDNWAIRKAMHKETVSGKYNIETPKGKIATAVRGSLADIKNEKHLAKITDPQIREVILPNHLKKYVDEKGKINFD
IAFSDEGIEDLNKNIVALNYGKNHQPIRKIKFFEVGSKFSISENENSAKNKKYVEAAKGTNLFFAVYWDGKKQKRNYETI
PLNEVIAHQKQVAHLPKSERLPIQPNNKKGEFLFTLTPNDLVYVPTDEELTNINAIDFNNLNQEQVNRIYKVVSFTNTRL
YVVPFYSAKPIYNKVEFTQLNKVEFTDEKIFMFKLQVDRLGNISKA
>cas__A0A0A7HFE1 Cas10 | cas | Type III large subunit | Streptococcus thermophilus
MKKEKIDLFYGALLHDIGKVIQRATGERKKHALVGADWFDEIADNQVISDQIRYHMANYQSDKLGNDHLAYITYIADNIA
SGVDRRQSNEESDEDASAKIWDTYTNQADIFNVFGAQTDKRYFKPTVLNLKSKPNFASATYEPFSKGDYAAIATRIKNEL
AEFEFNQAQIDSLLNLFEAILSFVPSSTNSKEIADISLAEHSRLTAAFALAIYDYLEDKGRHNYKEDLFTKASAFYEEEA
FLLASFDLSGIQDFIYNIATSGAAKQLKARSLYLDFMSEYIADSLLDKLGLNRANLLYVGGGHAYFVLANTEKTVETLVQ
FEKDFNQFLLANFQTRLYVAFGWGSFAAKDIMSELNSPESYRQIYQKASRMISEKKISRYDYRTLMLLNRGGKSSERECE
ICHSVENLVSYHDQKVCDICRGLYQFSKEIAHDHFIITENEGLPIGPNACLKGVAFEKLSQESFSRVYVKNDYKAGTIKA
THVFVGDYQCDEIHKYAALSKNEDGLGIKRLAVVRLDVDDLGAAFMAGFSRQGNGQYSTLSRSATFSRSMSLFFKVYINQ
FASDKKLSIIYAGGDDVFAIGSWQDIIAFTVELRQNFIKWTNGKLTLSAGIGLFADKTPISLMAHQTGELEEAAKGNEKD
SISLFSSDYTFKFDRFITNVYDDKLEQIRYFFNHQDERGKNFIYKLIELLRNYESEEKMNVARLAYYLTRLEELTDKDER
DKFKQFKKLFFKWYTNNESDRKEAELALLLYVYEIRKD
>cas__P71629 Cas10 | cas | Type III large subunit | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
MNPQLIEAIIGCLLHDIGKPVQRAALGYPGRHSAIGRAFMKKVWLRDSRNPSQFTDEVDEADIGVSDRRILDAISYHHSS
ALRTAAENGRLAADAPAYIAYNIAAGTDRRKADSDDGHGASTWDPDTPLYSMFNRFGSGTANLAFAPEMLDDRKPINIPS
PRRIEFDKDRYAAIVNKLKAILVDLERSDTYLASLLNVLEATLSFVPSSTDASEVVDVSLFDHLKLTGALGACIWHYLQA
TGQSDFKSALFDKQDTFYNEKAFLLTTFDVSGIQDFIYTIHSSGAAKMLRARSFYLEMLTEHLIDELLARVGLSRANLNY
SGGGHAYLLLPNTESARKSVEQFEREANDWLLENFATRLFIATGSVPLAANDLMRRPNESASQASNRALRYSGLYRELSE
QLSAKKLARYSADQLRELNSRDHDGQKGDRECSVCHTVNRTVSADDEPKCSLCQALTAASSQIQSESRRFLLISDGATKG
LPLPFGATLTFCSRADADKALQQPQTRRRYAKNKFFAGECLGTGLWVGDYVAQMEFGDYVKRASGIARLGVLRLDVDNLG
QAFTHGFMEQGNGKFNTISRTAAFSRMLSLFFRQHINYVLARPKLRPITGDDPARPREATIIYSGGDDVFVVGAWDDVIE
FGIELRERFHEFTQGKLTVSAGIGMFPDKYPISVMAREVGDLEDAAKSLPGKNGVALFDREFTFGWDELLSKVIEEKYRH
IADYFSGNEERGMAFIYKLLELLAERDDRITKARWVYFLTRMRNPTGDTAPFQQFANRLHQWFQDPTDAKQLKTALHLYI
YRTRKEESE
>cas__E6LHV7 Cas10 | cas | Type III large subunit | Enterococcus italicus (strain DSM 15952 / CCUG 50447 / LMG 22039 / TP 1.5)
MNKKLELMYGSLLHDIGKIVYRSNSVDFAKGTHSKIGSQFLNKFKPFQLSGIVDSVSYHHYKELASSSLLDDSVAYITYI
ADNIASGTDRRASEGDYEGEGNRQRFDKRAPLASIFNVVNSETKGLANYTYSFEKEQVYRYPTDAKKEYTSSQYAALVNK
MTDDLSNKLKVGPDSFSSLLQWTESLWSYIPSSTDTNQVMDVSLYDHSKITCAIASCIYDYLTEMNCVNYRKELFSPYEK
TKQFYQEDVFLLVSLDMSGIQDFIYNISGSKALKSLRSRSFYLETMLESLVDDLLSDLELSRANLLYTGGGHAYLLLPNT
ERARDVLASFEGEMKEWFIKIFKTDLSVAIAYKACTGEDLMNSNGTYSDLWQTVSRKLSDKKAHKYSLNEIKLFNSTIHA
GTQECKECLRSDIDISEDSLCKICEGIIAISNDLRDYSFFVVSPEGKVPLPRNRYLSVENQDGAERKIKMNKETRIYSKN
QPFVGKQLVTNLWMCDYDFSTLNPETKKQGIASYVNREVGIPRLGVLRADIDNLGTTFIKGIPEQYRSISRTATLSRQLS
MFFKFELSNILKGARISVIYSGGDDLFLIGAWDDVISKALVLRKAFTRFSAGKLTFSAGIGMYPVKYPISKMASETGVLE
DLAKRGEKNQVALWNDSKVFGWSQLEEQILKEKMIPLQEALTNSQEHGKSFLYKMLELLRNEDQINIARLAYLLARSSLS
EELTQSIFAWSQNKQQKVELITAIEYLVYQIREAD
>cas__B6YWB8 Cas10 | cas | Type III large subunit | Thermococcus onnurineus (strain NA1)
MEIDELTALGGLLHDIGKPVQRAGLYSGDHSTQGARFLRDLAENTGRAEYELLSLFSEFHHKGHMKNDELMIRRIKELSP
ERFGLTMEDVLNALWIVYEADNLASGEREEGQPQASRPLYSVFNPGKAYPWAELDFEKELPVPGDVFSIRSQDYRELVKR
LWEELSKAKLRSDRLLPVLEKYLTFVSSVTSEGNIISLYDHMRMTSAIALAMLRAGCTAEDVRSGRCRKEKRFLLIEGDF
SGIQDFIYRVSGKGTLKYLRARSAYLELIGWDVVLEILSRLGLTRANVVFNAGGHFMIIAQNTPDAVKELEEIRAKAVEW
LYREFESDLYLAIEWEPVSGREFGREGGKNLFAEARKRLKHKLTVRKLKRFGEIKGLFEHGHTERLAECPVCGRELPEGK
LEPSASDPETKVCPTCNRLVSLGGNLPKLLGFGRTAKNDAGVLVEGPFSGFVPYLQGGRPVGEQILVKNTLNPGEIPESA
QFVPYFVADYFKKDPKGGVATFEELSMASTGTRRLGVMKGDVDRLGEFFSSMDSPSKLATASRFMDYFFKGYIGAIIEGK
FGYIIGDVPSLRDWPEEPDIVVVYAGGDDFFIVGAWDQIFELAFRVRRAFNAYTGGKLTLSVGLGYFDERTPIYRMADVV
SERLDTAKDEGRNRVFVVGRSRPLDGKHKLSYEWNHYEELWRTYAPRIYAGNGRLKGKLESKKGLLWKLLEIRELYVRDP
NDVRWAYLTAYLLGRHGLSDLFPELVGIDTKAVERKEPQPVYWVDGVLKIVLMAVRR
>cas__Q53W19 Cas10 | cas | Type III large subunit | Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)
MLGDGLSVALAGLLHDVGKLYSRARWGERDDQVPDRTHTAYTAHFVREHAGLFRGAGLDPDWLARTASRHHEGWRDRPQY
RPETPEEWCVALADTYASKEREEGEGGGSPPEVPLSPPFRRLLLGGEEGREGGYSPVGAGGRVGLEAGGLYPEERPNVSK
DVYKRLLERLEGRLEEMARFSLGKEALVLNLALALQETLSLVPSDTQSEPDVSLYDHLRLTAAIAHALWLFHGGSPSAQN
LRQDGEKFLLVVGDMGGIQGHIYRIAGAEAGVGGIAKRLRARSLEVSLAAEAMALGLLWRLGLTSLNRILGAGGKFYLLL
PNTEEARAALEGTREAWGRWALKRGGSLVPHLAWVAFRGQDFRDFAALLKRLHEALAREKLRPFAFLASTGGVLGAPLRP
CAACGLEPARRDEPGSLCPDCEREAALGARLPRSDRVGFFLEEAPRPYLDFPGLKVGLGGPLEGAFHLFRARLDFAPWPD
PSEAKPLLGHLPRVEHALKAKGWSLEAYRAWAEEEGLLEDEEPHPEKVLTFAELAALSEGAPYLGALMLDADRMGEAFAT
GFRREGRDLATPSRLAALSRTLEVFFTTEVLTLLEEPRRYRERLGWDDLEAQRKEARYPLLYSVYSGGDDLFLLGPWDAL
LDFALDLERLYRLFTRHPRLTLSGGFLLVPPSLPVPELARLLGEAEKRAKAEGRERLFLFGQAVPWETLRGLRAWAEGLR
QDLRAERVSRAQVYRWLLLWRRFSPLEDPGERMRYKPLLAYALRRVRERDEEAWKRYLKLLDHQDPAWAYLPVWVQWALY
RERRV
>cas__Q59066 Cas10 | cas | Type III large subunit | Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)
MGNCNEYTALKIGALLHDIGKFIQRASDKPKSKGHDKFGYEFLKEKFKNGFLNHLDEKTKDKILEIVKEHHNQKIKDDLI
GIVRLADWLSSGERREPKGDPENVEVLNTEEQKLLSIFETVCIGELTENLYKNGFKYSLKPLNVSDAIFTDKPYPNENYK
ELFSKFEDEIKDFKGDVSFEELYQLMQKYTWCIPSVTMWKKAGSLKGGLPDVSLFDHSKTTCAIACCLYQMYVKENKKKN
KYAKEYIDDKTLEKLFNNDNGWNKEIFSLIHGDLSGIQDFVFTITTKYATKSLKGRSFYLDFLTEYFAKYICKELNLPIT
NILFYGGGHFYILSYKVDENLINKLEKEINEVLFNMFRTKIYITIAEVGVTPNDFKKSEDKESKEKTWGFAKKWKEVSEK
TVEKKLRRFEYKLEGLFEPYNRGSENRCVICRNEFDKNEKGYAIRENESKSERICDYCASFVALTDILKNFQMEKTIKFN
KAYPIIHLTKNKDNLSLQREEFSFLTVKAIEKLESKFRVLSDENYFLKEYKLPHDSGELIIPYKIWAIAFPIIENETEKR
ILDFDGLAEKAFERTGTRKIGILKMDVDNLGEIFTTGLGNDATISRMSTLSSMLTLFFTGYIPHLIKNEEFEVNGKKYKF
KDNIYLVYAGGDDTLIVGAWDAVWELAKRIRGDFKKFVCYNPYITLSAGIVFVNPKFEFKKAVNMAEEELENGKNYIIYE
DEETEKKVDKNALTVFNCPMNWDLEVEYNEYCWTKLKSYLEGINKEMVELESLVKKFNEDDLEKNLKKQLKRQIRKESYI
>cas__A0A089QBM9 Cas10 | cas | Type III large subunit | Ligilactobacillus salivarius
MDNKMNSLFYGSALHDVGKIVQRSTNERITHSRIGVNYLKKFTDNIDILHQVNYHHVKEINGAKLENDDLAFITYIADNI
ASGTDRRKIETDTKRQWDSKTNLEDIFDRFGENSTRRYIVPSMLSEDTSKIFPVKDKVEFNSSEYTKIVTRITNTLSVIN
FAPDYQQSVLNLIEATASFIPSSTNVQESVDVSLYDHMRLTAGIACAIYLYLEEKQEYNYKNTLYNNSQNFYRQNAFKLV
SFDISGIQKFLYTITTSGAHKQLRSRSFYLDMISETIVDSLLSKLDLSRANVIYSGGGRAYLVLPNTKSADKAIKEVEKE
FNQFFIDKFNIQLYVSFGSSIFTANDLMDKKDNEKIYNSIFREVSHQISERKLSRYDVSTIKQLNMGGKKVGRECIICHS
VDNLVEGENKCQLCFSLENFSSDLQKEKYFVVDDEVSGLQIGPNMYIHKVSEEDIKSGKVNGKIYTKNEFVTGADQSIRL
MMGDYSYLHNNEFGKYSDRDWTKVDSSSSPVGIKRIAALRCDVDDLGYGFIGGFKEQDSGKYNTFSRIATFSRRMSIFFK
TYINSFAKDKRLTIVYSGGDDVFILGAWDEVIEFAIDLRQKFISWTDGKLTLSAGIGMFDSKTPINVIARETGTLEDAAK
DNDKNSIALFDIKYTFNFDYFIDNVYNSKLSYIKEFFENQPEQGKTFIYRLLDLIYNRDTKDRISFARIAYTLAKAEESI
PKEKRKEFIDFKSKMLNWFEDEKEILSTELALMLYIYQIRKDR
>cas__A0A097ASV1 Cas10 | cas | Type III large subunit | Thermoanaerobacter kivui
MIFYNIYSSEEEKIFDHRLFLGALLHDTENTILKDFQITSLIPSYYKPSEYEELLTSIAAKISAATDGEGYDEIEEESQK
VKQMISIFSNIKLEEEKEQKSNQDLYYKLLSKKYEIEFPYNSPKENSSKDYEELWKEFFLKMNQLRQNFKESIDIEDYAT
AVYNLMQQYTYNIPSAFYHSKLDISLWAHSKSTAAIAFCLDRELKYRFKGDTVRIRKELETILTKLKNKGSIQKGDGELF
CLVKGDVSGIQDFVFDTKMNGALKALKGKSFYIAFLLDTIARFILKEENMPICNLIYNGGGHFYLLMPKSFEERLPNYQS
IMNSIMFRYHKGALSVLLGSCSIDLLSFMSNIGEKFDEVAKKIQIRKSKKFDDIIKNEKLKFFEPFDDFENKCPHCGNLT
YTNENVCTFCDSFVELGQKLMKSLFIIDNWGRPEVSEKPGDIYKILAEFGRRIKFSSHYESISNTIIIDMVKIQELEKEN
SLSKKDIFEVEYYEALDISTYVPMDKDGDIKLLDDIVKESKGLKTWGIVRGDVDNLGRIFKDGLKDKNSLSRVMTLSQEF
SLFFGYYFNKLTKEQGPNSVIIYAGGDDFCVLGPWSDMPHLASTIYKKFRDYVCQNEDITLSMGFEIAPDKKYPIYRVAT
VCGEHLDGAKKFERKNGKKKDCFAFGGNFVGWEDFEDLKNIKEKIVHLVKDKNVSKALINVIYSVDKLEKMANESSEMFK
SWRFVYYIAKLKDRYKRLKDELDEILNAIIKKETNSLYEYAYLAARWAELEIRS
>cas__A0A098S2D5 Cas10 | cas | Type III large subunit | Phaeodactylibacter xiamenensis
MNESYSEQLDMLFEDIKLPEKDYSTFLKIDISGIQDYIFHVQSDKAARTLKGRSFLVQALGWLAEENIKQAVNDDCYTIY
NGGGNVYMLVNEEEALLDGMEGRLNDVLTPYSLYICISTVSYAAKDFRNCKRALEQQSAKDKQRKYQGQHEAFHSFELPR
DLPDREEKNQEDKWHVLTKQLVKHKGYTIETADGSQQDLLGADGVIRLGDFQLKIVRNPTEDKKLDKSILVNLPTWDNDL
LDDGRLKERINKEYKRQAKRDGTPERTVEAGQILEFSVLAALAGKRTGTPKLGILKMDVDNLGMVFGDLPDAQAMTYLSK
AFKWFFEERFCEIWNEAFEYNCHARGSDGKYQTKGNPQKKPYSQNLYVVFAGGDDCFVLGGWDTILAFADRIESEFQQFV
LELKQHKRTEFLSDRKVTLSAGVELVGPKHPTILFARAANEAIDTAKDYEKERKDEAGKLSNGKHRICLFNEALSWEDYR
NCQTWRDRLAGLISSKRCNRSLFYRIQHSSAGFQEMPHPSALQYKQDKFPEEWHLYHFLGRMRNTSSGTFKTVDELVKAY
APALLKVYKNNGGNTHMTYPLAARLAEFSTRTIKLSSDE
>cas__A0A0F7PYD9 Cas10 | cas | Type III large subunit | Ligilactobacillus salivarius str. Ren
MDDKMNSLFYGSVLHDIGKIVQRSTNERITHSRIGVNYLRKFTDNIDILHQVNYHHVKEINGAKLENNDLAFITYIADNI
ASGTDRRKIETDTKRQWDSKTNLEDIFDRFGENSTRRYIVPSMLSEDTSKIFPVKDKVEFNSSEYTKIVTRITNTLSVIN
FAPDYQQSVLNLIEATASFIPSSTNVQESVDVSLYDHMRLTAGIACAIYLFLEEKQEYNYKNTLYNNSQNFYRQNAFKLV
SFDISGIQKFLYTITTSGAHKQLRSRSFYLDMISETIVDSLLSKLGLSRANVIYSGGGRAYLVLPNTKSADKAIKEVEKE
FNQFFIDKFNIQLYVSFGSSIFTANDLMDKKDNDEDNEKIYNSIFREVSHQISERKLSRYDVSTIKQLNMGGKKVGRECI
ICHSVDNLVEGENKCQLCFSLENFSSDLQKEKYFVVDDEVSGLQIGPNMYIHKVSEEDIKSGKVNGKIYTKNEFVTGADQ
SIRLMMGDYSYLHNNEFGKYSDRDWTKVDSSSSPVGIKRIAALRCDVDDLGYGFIGGFKEQNSGKYNTFSRIATFSRRMS
IFFKTYINSFAKDKRLTIVYSGGDDVFVLGAWDEVIEFAIDLRQKFISWTDGKLTLSAGIGMFDSKTPINVIARETGTLE
DAAKDNDKNSIALFDTKYTFNFDYFIDNVYNSKLSYIKEFFENQPEQGKTFIYRLLDLIYNRDTKDKISFARIAYTLAKA
EESISKDKLENFTDFKSKMLNWFEDEEEILSTELALMLYIYQIRKDR
>cas__A0A0M9AEE5 Cas10 | cas | Type III large subunit | Thermus aquaticus
MVRDGLDLALAGLLHDVGKLYGRALWGERDERLPDRTHTAYTAHFVQKEAELFRKAGLDPDWLAKTASRHHEGWRDRPQY
QPQSPEEWCVALADTYASQEREEGGQGGSPPEVPLQPPFSQLRLQGKEGRDGGYLPVGGGGRVGLAPGALYPEASVPMGK
ATYGRLVERLEARLSEMARLSLTKEALLLNLALAFQEALSLVPADTQSEPDVSLYDHLRLTAAIAHALWLYHGGQPSVEE
LRRDGEKFLLVVGDLGGIQGHIYRISGAETGVGGIAKRLRARSLEVSLAAETMALGILRSLGLTPLNRILGAGGKFYLLL
PNTKEAQEALEEAREAWGRWALRRGGSLIPNLASLAFEGKEFRDFAGVLKALHKELAQAKLKPFPFLKKTEETRGEALRP
CAACGLRPALKDEPGSLCPDCEREREVGGLLPKRDRVGFFPDGAPRPFFAFPSLKVALEDGPGAVHVFRAELDFRPSAVP
TEAKPLLGHLPRVAHALKAQGVSLADYTAWAREEGLLEEEEGGEDRVLTFGELAALSEGAPYLGALMLDADRMGEAFATG
FKREERDLATPSRLAALSRTLEVFFATEVLELIRNPALYAGRLGWDALKARRKGERYPLIYSVYSGGDDLFLLGPWDVLL
DFALDLERLYALFTGHEALTLSGGFVLAGPSLPIPELARLLTRAEKAAKEAGRGRLFLFGQAVPWAHLRNLRQEVEALRS
DLRAERVSRAQVYRWLSLWRRFWGQDMNEGERMRYKPLLAYALRRVRERDKGAWKRYMGLLDHQGPAWRYLPVWVQWGLY
LSRKTREEPLEVKA
>cas__A0A0X8XBW3 Cas10 | cas | Type III large subunit | Halorhodospira halochloris
MSTEQIKTSWRTQDHVVLGALIHDIGKLFERGDLLDSYRNDEDMLQAYCPFQIRGRYFSHKHAVHTLAWAERLAERIPAL
DPEHLGIGTDHWLNLAARHHKPSSALEALIKRADDLASQERDPLGIDARFISRKVRLEPILERVTLEADPGRARTTETRV
PLTPMEPGSPYFPEHAHKMDPPMNWDREKCAWVSQQDLGDAYARLGQDLLGQLEQLPTAEAPPSAIIGTLLTLLERYTAQ
VPSATNTAHPDISLFDHLRVTAAIAEGLYTYHQDQGDGLENVEKRDQTAKWALVCGDLSGIQRFIYRITSRGAARALRGR
SLYLQLLTDGLASRMRRELDLHAPAQIYASGGKFFLLIPSTRVDQARQVAATINDELLAPFQGQLRLGLGTAHLAPNHFR
AGHMGERWQATIDDLHRDRTRPWAGRMAHPPEKEDQDFFAPESPSEDGHCHACGRDDPPGDICDRGEGRRLCQQCNDLEQ
LGLAIRHASAITWHEPGTQRRGWELPGTGRVIRLPSREDPESLPLAAGDVLERLEGWPELAEARPGIAYSARFIGRWQES
CGESELEELAASSQGIKRLGILRMDVDNLGQIFARGLRFGSTTETESSADMGSLSRTATLSRQLHWFFSTHLTRLLEQAE
APAQIMYAGGDDLFIVGAWHAMPELAVRIQHDLQRFASHNPVFSLSGGIELVGGRYPIGHAAELAGIQEEHAKGHRRSDK
EGQTRDKCALAFLHTPVGWEQMEHVEGVREQLERFLEATGNRAVLGYLRRAVADMEGLQRRYAQGRWSDTELHALVEAQR
WRWQLLSRLRRLRRRHQHHTEAVGAIDRLQEVFIEQQQPHKPPDPHLLGLPGRWVELKYRQSGNYLPDRGEEVHAP
>cas__A0A150IUS0 Cas10 | cas | Type III large subunit | Candidatus Methanofastidiosum methylothiophilum
MNQVRENSINQPSLEEITLGALLHDIGKFAQRAGEEDFKKEEMRPLIQKKDKKTERYTHDHALYTFGIVESIRDALPLKI
RYEIVASLAACHHEPSTIFDKMIQLGDIISAGLERKEYADTETSDEKKQFYEIPLSCILDQVDLIGKKSPKRFYNLAPLS
PDSIFPTSTTMVGKKEYANLWKLFYNDLLKLRVQEFENYLDALIAIYEHYLWCIPSSTIQEPDISLYDHSITTTAFSACL
YKYYMETNGQNIGSFDFNLKEPTFLFISGDVSGIQSYIFDLKTTESNAKLLRARSFEIELLTTQAANLIIKTLNLPKVCI
LTNAGGQFLILVHNTEEVKTKIRKLRETIERYFLNHFLGELSLNISEPVESSISDLKQEEFPHLLQKIKDSAIASKYKKF
NSLLKTKSDHILDKEYNRIQEKDAVCPVCDQRAGEEKKEGILICRTCNRLIKIGEKLPKALAVEAQKDARLGVEDVYLLT
ESQLKQTKFAYSINKYRIGLGIYHMPYHIPLKDTGEPLTFEELAEQGEGTKKIAMFKADVDNLGAVFSIGMKGHISISRY
AALSRTLHYFFSTYLNHFIEKNYPKYIYTVFSGGDDVCIIGPWNKVIDFALSLQQEFQRLVGENPSITLSAGVILAHPNI
PVRTIASEAEEALKKSKEADPEMKEKNKITLFETTVTWKEFKKLMDEANKLFYLLDRKKISQAFLYRLLQYHNMNKLITK
DHKNISRNILWISHLYYDIARNLKDENNIDYEKNKNYLKEFVHNYIQTLRIPVSYVLYRVRKD
>cas__A0A173V795 Cas10 | cas | Type III large subunit | Faecalibacterium prausnitzii
MNVLTLQSTYGGLLHDTGKAVYRAGGQRGSHSEQGCQFLHGVLSGADWTPVLDCVRYHHAAALRGAAKTLPADSPAYLVY
LANLLSGAADRRETEGESDAYRRELPLDAVFTHLNGSHPGWAMPAQPQDGSLKLPQKSQPLSAAVYAEAVRTLEEQLPQL
QPQPEQLGKLLGLLETQLGCFPSSIYPGDGADISLFDHAKTTAAIAACLSEYVQANHITDLRKALFEQKNDFCRKGVFLL
YTADFSRIQKFLYTVRTENALRSLRSRSFFLELFMEHYLDELLAGCGVSRANLIYSGGGHCYVLLPNTAAVADTLTRWNR
QFNRWLQQQFGTQLFLANAWTPCSGNDLTNTPAQSSPYKELFRRVNRLLEQHKFHRYTAEDLRLLNDAAAYPGGRECKVC
GTSAALADELCPWCRLFVDFSDKIQHRSVLVVSRQPSAADDCTLPTLDGGSVYLTTTDRASAQKRLSSGEPILRAYTKNT
PYSGLPSTTNLYVGDYAASNSMDELAQQAAGVRRIAVCRMDVDNLGHAFISGFEQESEKDPVRRMRYVNLSRTSAFSRQM
SLFFKGYINGILDGLQVSIVYAGGDDVFLVGAWNDVLEAAQRIQRNLTAFSCGALTLSAGIGIFDPHYPIRLSAEETAAL
EEAAKHLPGKNAVALFTPERKAVRDAKGNLLVQPEQGHAYAWDTFRTKVLEEKVGCLQRFFQAYDRSCADKGETPRGNSM
LYNLLALLREAENDRINLARYAYLLARLSPKKNAPDYPLYEQFSHSMMAWALDAVQRHQLITAIYIYVYQNRKGGDTDGR
ME
>cas__A0A179D2K0 Cas10 | cas | Type III large subunit | Thermosulfurimonas dismutans
MKGFVNACFLHDIGKIILRSKEGHSGKNHSEEGAKWLSKRLSEIGRDSLNKIIYLVELHHNLKEAEEIPLLALLQKADHL
AAGERETSKGKCTGPYKWDWYAPLATPFSRISLKNPRPQDPYPAFWPLEEVSPDLPSAAKCPSRTTPEKYAELLENFEKN
FLEIAKNGDLSPNKLLVILEKYFSFVPSETCVPKEGYKDWPDISLFDHLKLTAAIGSVYYLWLEEKYGPDFIKHQFVIEE
LSNRNQQPFILVGGDLSGVQNFIYTISSKGALLSLKGRSFFLELLMEHTINRILSEAGLYRCNVIFSGGGHFYLLLPNTK
SAEGILETTKRKINDWLWRKFEALLELHIVWEPFGEEVFISQKKGIRAGDIFAKVSEKLEKSKKKPFSEQLSSMFEPISI
HPSCLEAEGAPGACEVCFRDEVNISNRSDDVNLILCDACYDEYRLGKNIQQQSGKNKNLFSSYLNINNHGVITIENKGYE
FDSKPQDDTYFAVNHFSPGAEAFLPCGYYQGIWEFEKIKEEGFGLPRLSALRMDVDNLGRIFKEGLLPEDQTFSRISAIS
RSLNLFFKYYLNTLLCGRNHLPGYKPPERFNWAKRDIDQDGRKVAIIYSGGDDLFIMGAWLDVCEAAIDIVKAFSSYTGN
PELTLSGGIALGPIKMPVYQFARLAGAGEDKAKDLRPKKNALFILGEVIPNESLINLKEMLNFWQKYLEPDTQKASLILK
EPFSKAFLYRILNIAQELTREDDKKDKAIFLPRIAYLLSRLDREKLKKDYLTLQNWLLSLDFEKNWKLMHVAMQWIIMSM
RREDNE
>cas__P39620 Cas11 | cas | Type I/III small subunit | Bacillus subtilis (strain 168)
MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQPMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPT
PSGPGQSVPGMLPVEESYIENILRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY
ITFDEEIAYTYPYSMASYSPR
>cas__A0A6M3ZHV6 Cas11 | cas | Type I/III small subunit | Bacillus subtilis (strain 168)
MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQPMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPT
PSGPGQSVPGMLPVEESYIENILRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY
ITFDEEIAYTYPYSMASYSPR
>cas__A0A6H0WNM2 Cas11 | cas | Type I/III small subunit | Bacillus tequilensis
MKPKKNQYQQMQGFDNMQGFQPQYGPNPYPQQGQGGQMQMMGMQPMMPTMQQGQQQGQQGFGFPSQQQGGGFQIPSGPTP
SAPGQSVPGMLPVEESYIENILRLNRGKTATIYMTFENSKEWPSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDYI
TFDEEIAYTYPYSMSSYSPR
>cas__A0A6I7U6N4 Cas11 | cas | Type I/III small subunit | Bacillus paralicheniformis
MKFKKNQIQPLQELEMPDFRQQMGPNPYPQMGQMGQMYQQHGQQPFTQTGGQQSYQQPGPQLFQPQPAGVQVPPMPSAQQ
TSPSIPGMLPLEQSYIENILRLNRGKVATVYMTFENNPEWNAKVFRGEIEAAGRDHIILSDRKTGTRYLLLMVYLDYITF
DEPITYDYPYSMASYTPR
>cas__A0AAE2SMR1 Cas11 | cas | Type I/III small subunit | Bacillus subtilis subsp. subtilis
MKPKKNQYQQMQAFDNMQGYQPQFGANPYPQQGQGSQMQTMGMQPMMPMQQGQQGQQGQQGFGFPGQQQGGGFQIPSGPT
PSGPGQSVPGMLPVEESYIENILRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKSGTRYLLLTIYLDY
ITFDEEIAYTYPYSMASYSPR
>cas__A0AAI8HKF8 Cas11 | cas | Type I/III small subunit | Bacillus siamensis
MKPKKNQYQQMQGMGMGMDMQGYQPQLGPNPYPQPQGQGSQMMPMQQQMPMPMQQSQQGFGGGFSGQPQQQGGGFQIPSG
PSSSQSVPGMLPIEESYIENILRLNRGKTATIYMTFENSKEWNSKIFRGVIEAAGRDHIIISDPKTGTRYLLLTIYLDYI
TFDEEIAYTYPFSMSSYSPR
>cas__A0AAP3CLG6 Cas11 | cas | Type I/III small subunit | Bacillus vallismortis
MKPKKNQYQQMQGFDNMQGYQPQYGANPYPQQGQGGQMQTMGMQPMMPMQQGQQGQQGFGFPGQQGGGFQIPSGPTPSAP
GQSIPGMLPVEESYIENILRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIILSDPKSGTRYLLLTIYLDYITFD
EEIAYTYPYSMASYSPR
>cas__A0AAP3FVX8 Cas11 | cas | Type I/III small subunit | Bacillus mojavensis
MKPKKNQYQQMQGYDMQGYSPQFGANPYPQPQGQGPQMQGPMQGPQMQTMGQMQQMPMQQGQQGFGFPTQQQGQGGGFQI
PSGQTPSGGQNIPGMLPVEESYIENILRLNRGKTATIYMTFENSKEWGSKIFRGVIEAAGRDHIIISDPKTGTRYLLLTI
YLDYVTFDEEIAYTYPYSMSSYSPR
>cas__A0ABF7SXI7 Cas11 | cas | Type I/III small subunit | Bacillus amyloliquefaciens
MKPKKNQYQQMQGMGMGMDMQGFQPQLGPNPYPQPQGQGSQMMPMQQQMTMPMQQGQQGFGGGFPGQPQQQGGGSFQIPS
GPSSSQNVPGMLPIEESYIENILRLNRGKTATIYMTFENSKEWNSKIFRGVIEAAGRDHIIISDPKTGTRYLLLTIYLDY
ITFDEEIAYTYPYSMSSYSPR
>cas__A8FIM2 Cas11 | cas | Type I/III small subunit | Bacillus pumilus (strain SAFR-032)
MKLKNQFGQGSGFEGQDFRQQQYGANPYPAQQMGYSVPPQTQGQMQGQMQQGFSPMPSTGSSQGGQGMQSSGQPYQIPSG
PIYQQNVTGQLPIEQSYIENILRLNRGKVATIYMTFEASKEWNSKIFRGVIEAAGRDHIIISDNKTGTRYLLLTIYLDYI
TFDGEIQYDYPYSMSTYSPR
>cas__A0A0C6FPH4 Cas12 | cas | Type V effector | Methylobacterium aquaticum
MTQSTPPGPPTIAAADAAQDGAPRGAVPALPPSVQEHLGERLRAHYAAVEVEAAPAAFADLLGRLELALAALGAPKKDGF
RDDLLAATPSLRRFALTLTANPARADDLVQDTMLKAWQNRDRFEAGTNLSAWLFTIMRNAFYSEHRKRSREVEDSEGAYS
ARLTSAPNQGDRLDVQDLQAALNKLVAEQREALMLVAVGDLSYEDAAALMQCKVGTVKSRVCRARDKLAELLGYSGGELG
ADRLTRSVMGHAGTVSLDG
>cas__A0A6L3SXY2 Cas12 | cas | Type V effector | Methylobacterium soli
MRSDEIQTAPDRRLDQDSDARPNLSPSIRTHLGDHLRTAYESIGQADLPSRFADLIEKLEAALKARGEAIEPEFRNGLLA
AVPSLRAFALSLTSNPARSDDLVQDTLLKGWQHRARFQPGTNLNAWLFTILRNIFYSDHRKRVREVEDQDGSYAARLATA
PHQGDRLDVEDLQSALAKLPPDQREALVLVGAEGVSYEEAATIMGCKVGTVKSRVSRARGRLAELLGYDEEDLGSDRFIQ
SAMPKDA
>cas__A0A4Z0NW97 Cas12 | cas | Type V effector | Methylobacterium nonmethylotrophicum
MTQSTPPGPTKAAPSKAAPTTAPTKTAPALPLSVQEHLGERLRAHYAAVEEVEAPAAFAELLARLEQALAIMGAPKKDGF
RDELLAAAPALRRFALTLTANPARADDLVQDTMLKAWQNRDRFESGTNLSAWLFTIMRNAFYSEHRKRAREVEDGEGVYS
ARLTTAPNQGDRLDVQDLQAALNKLVAEQREALMLVAVGDLSYEDAAVLMQCKVGTVKSRVCRARDKLAELLGYTGGELG
ADRLTRSAMEHAGAMVLDG
>cas__A0A2U8W2A0 Cas12 | cas | Type V effector | Methylobacterium durans
MRSDEIQTIPDHPDRDADARPNLSASIRTHLGDHLRTAYEAIGQAEMPNRFVELIDKLEAALRAQGEAVEPDFRDGLLAA
VPSLRAFALSLTSNPARSDDLVQDTLLKGWQHRARFQPGTNLNAWLFTILRNIFYSDHRKRVREVEDQDGSYAARLATAP
HQGDRLDVEDLQSALAKLPPDQREALVLVGAEGVSYEEAATIMGCKVGTVKSRVSRARGRLAELLGYDEEDLGSDRFIQS
AMPKEA
>cas__A0A6N6MTU7 Cas12 | cas | Type V effector | Methylobacterium planeticum
MRSDEIQTAPDRRLDQDSDARPNLSPSIRTHLGDHLRTAYESIGQADLPSRFADLIEKLEAALKARGEAIEPEFRNGLLA
AVPSLRAFALSLTSNPARSDDLVQDTLLKGWQHRARFQPGTNLNAWLFTILRNIFYSDHRKRVREVEDQDGSYAARLATA
PHQGDRLDVEDLQSALAKLPPDQREALVLVGAEGVSYEEAATIMGCKVGTVKSRVSRARGRLAELLGYDEEDLGSDRFIQ
SAMPKDA
>cas__A0AAE8L4T9 Cas12 | cas | Type V effector | Methylobacterium phyllosphaerae
MSETESGPGSVTDADYRNLAETLPQLAWIAEADGTIIWYNQRWYDFTGTSLEDMRGWGWRTVHHPDHVEAVTERYRAAIT
LGRSWEDTFPLRGRDGTYRWFLSKALPHRDESGRILRWYGTNTDITGRRAIEERLRHSEQRFRALVDASAAVIWNTNAAG
ELMPPQVRWSIYTGQTEEAYQGWGWLDAVHPEDRGHAADAWAASVEARALYEVEYRLRRHDGAWRTMEVRGVPVLAEDGS
LREWVGTCVDVTDRKEAEEAVERARQAAEAANRAKSQFIANMSHELRTPLSAVIGYSEMLGEELEDIGQAALLPDLRKIE
AAARHLLSLINDVLDISKIEAGRMTASAETFAVADLLRDVGDSTGSLMEKKGNRFVLDAGEGAGADLGSMHQDQTKIRQC
LVNLLGNAAKFTEKGTITLTVRRHREEGADWLSFAVADTGIGMTETQIGRLFERFVQADDSTTRQFGGTGLGLAITRAFC
EAMGGDIGVTSVPGAGATFTVRLPAILSPEDAPTAEAEALTPVEPHEEHETVLLVDDDPAARELLQRFLEREGFHVRSAN
DGRAGLTLARALRPRAILLDVEMPRMDGWAVLHAVRNDPELAGTPVIMTSVVAEQGLGQALGATDYFVKPIDWDRLKGLM
ERYRPEAPNEARVLVVDDDADARERLRRSLGREGWTVDEAENGRIALERFSQARPSLILLDLMMPEMDGFGFLRALRSRP
DGDVPVVVLTAKEITTAEKESLNRQADRVIAKGSMSLAEIGRQLRVLYARSANEPVPGQLQGLLAQLAEQEGGERP
>cas__A0A0J6T803 Cas12 | cas | Type V effector | Methylobacterium tarhaniae
MTQSTPPGPPETAAETASKPAVPALPLSVQEHLGERLRAHYATVAEEAAPAAFADLLSRLDLALAALGAPKKDRFREDLL
AAAPALRRFALTLTANPARADDLVQDTMLKAWQSRDRFESGTNLSAWLFTIMRNAFYSEHRKRAREVEDCEGVYSARLTS
APNQGDRLDVQDLQAALNKLVAEQREALMLVAVGDLSYEDAAALMQCKVGTVKSRVCRARDKLAELLGYTGGELGADRLT
RSVMGHAGAVALDG
>cas__A0AA37WQU0 Cas12 | cas | Type V effector | Methylobacterium tardum
MSETEGGAQAVTDTDYRNLADALPQLAWIAEADGTIIWYNQRWYDYTGTTLEEMRGWGWRTVHHPDHVAAVTERYQAAIA
LGRSWEDTFPLRGRDGSYHWFLSKALPHHDASGRILRWYGTNTDITGRRTVEERLRHSEQRFRALVDASAAVIWNTNAAG
ELMPPQVRWSTYTGQTEEAYQGWGWLDAVHPDDQGHAADAWAACVEARQTYEVEYRLRRHDGAWRAMEVRGVPVLAEDGS
LREWVGTCVDVTERKEAEEAVERARQAAEAANRAKSQFIANMSHELRTPLSAVIGYSEMLGEELEDIGQAALLPDLRKIE
AAARHLLSLINDVLDISKIEAGRMTASAETFTVADLLRDVSDSTGSLVEKKGNRFVLDAGAGAGAALGSMHQDQTKIRQC
LLNLIGNAAKFTETGTITLAVRRHREEAADWLSFAVTDTGIGMSEEQIGRLFERFVQADDSTTRQFGGTGLGLAITRAFC
QTMGGDISVTSTPGAGATFTIRLPAMLRPEDAAPTEAEPHTPVEPHEQHETVLLVDDDPAARELLQRFLEREGFHVRSAN
DGRAGLTLARALRPRAILLDVEMPRMDGWAVLHAVRNDPDLAGTPVIMTSVVAEQGLGQALGATDYFVKPIDWDRLKGLM
ERYRPEAPGEARILVVDDDADARERLRRSLGREGWTVDEAENGRIALERVSQARPSLILLDLMMPEMDGFGFLRALRSRP
DGDVPVVVLTAKEITRAEKESLNVQADRVIAKGSMSLAEIGRQLRVLYARSASEPVPGRLQGLIDQLAEQDAGDRP
>cas__A0A089NSE2 Cas12 | cas | Type V effector | Methylobacterium oryzae CBMB20
MSETESGPGSVTDADYRNLAETLPQLAWIAEADGTIIWYNQRWYDFTGTSLEDMRGWGWRTVHHPDHVEAVTERYRAAIT
LGRSWEDTFPLRGRDGTYRWFLSKALPHRDESGRILRWYGTNTDITGRRAIEERLRHSEQRFRALVDASAAVIWNTNAAG
ELMPPQVRWSIYTGQTEEAYQGWGWLDAVHPEDRGHAADAWAASVEARALYEVEYRLRRHDGAWRTMEVRGVPVLAEDGS
LREWVGTCVDVTDRKEAEEAVERARQAAEAANRAKSQFIANMSHELRTPLSAVIGYSEMLGEELEDIGQAALLPDLRKIE
AAARHLLSLINDVLDISKIEAGRMTASAETFAVADLLRDVGDSTGSLMEKKGNRFVLDAGEGAGADLGSMHQDQTKIRQC
LVNLLGNAAKFTEKGTITLTVRRHREEGADWLSFAVADTGIGMTETQIGRLFERFVQADDSTTRQFGGTGLGLAITRAFC
EAMGGDIGVTSVPGAGATFTVRLPAILSPEDAPTAEAEALTPVEPHEEHETVLLVDDDPAARELLQRFLEREGFHVRSAN
DGRAGLTLARALRPRAILLDVEMPRMDGWAVLHAVRNDPELAGTPVIMTSVVAEQGLGQALGATDYFVKPIDWDRLKGLM
ERYRPEAPNEARVLVVDDDADARERLRRSLGREGWTVDEAENGRIALERFSQARPSLILLDLMMPEMDGFGFLRALRSRP
DGDVPVVVLTAKEITTAEKESLNRQADRVIAKGSMSLAEIGRQLRVLYARSANEPVPGQLQGLLAQLAEQEGGERP
>cas__A0A512IZ40 Cas12 | cas | Type V effector | Methylobacterium oxalidis
MRSDEIQTIPDRPDRDADARPNLPANIRTHLGDHLRTAYEAIGQAEMPNRFAELIEKLEAALRAQGEAVEPDFRDGLLAA
VPSLRAFALSLTSNPARSDDLVQDTLLKGWQHRARFQPGTNLNAWLFTILRNIFYSDHRKRVREVEDQDGSYAARLATAP
HQGDRLDVEDLQSALAKLPPDQREALVLVGAEGVSYEEAATIMGCKVGTVKSRVSRARGRLAELLGYDEEDLGSDRFIQS
AMPKEA
>cas__A0A5C4LD42 Cas12 | cas | Type V effector | Methylobacterium terricola
MTQSTPPGPPDAASAETVASGTVSSQSGPSGRTALPLSPPALPQSVQEHLGERLRAHYAAVAEEPAPSAFADLLARLEQA
LAIMGAPKKDRFREDLLAAAPALRRFALTLTANPVRADDLVQDTMLKAWQNRDRFEAGTNLSAWLFTIMRNAFYSEHRKR
AREVEDTEGVYSARLTSAPNQGDRLDVQDLQAALNKLVAEQREALMLVAVGDLSYEDAAALMQCKVGTVKSRVCRARDKL
AELLGYSGGELGADRLTRSVMGHSGALALDS
>cas__A0A7D5M640 Cas12 | cas | Type V effector | Nitrosopumilus oxyclinae
MVNCILIDDDPDIVDVFSELLHTINVDILATGNNGKDAVELYKKHKPDLVLTDLQMPRYDGYYAVENIKDVDSMAKFIMI
TGDLDVRNSNLLNLLNIPILHKPFDTQQIKQTIDDVLLRENEFPTSFQIQYKFKEDVNYYTCTVNYQQYRNFKLLPVIEE
CEITNQKNTKLFYEKMQNALNLATENDIAPIRKLSEVVSND
>cas__A0A7D5R9U4 Cas12 | cas | Type V effector | Nitrosopumilus ureiphilus
MVRCMVIDDDQNIVNVFCEILNIVGVDVVATGNDGNDAAIMYKMFHPDISFIDLNMPRYDGFYAIEEIRDMDLNTKIIAM
TGYSEYVKSNIFDSLNISIINKPFDIRSIKQIIVDSFLIESDLSKTSLFKIRYKFKEDNENYLCKVTYEQYRNLKKIPMI
EECEIVDNFQKNIDSYQNKMQKALDLASKDDFSYIKMISEIVPQLQ
>cas__A0A2S2KQN2 Cas12 | cas | Type V effector | Nitrosopumilus zosterae
MVSCIVIDDDQNTVDLFCELLSMIKVDVLARGYDGRDAVKLYEKHVPDIVFTDLQMPAYDGLYAVENIKDKYPDAKIIMV
TGDINATESELLESLNVHVIDKPFDIHTIKQTVTDVLLDEDSKSSIKIQYMFKEDDSVYSCVVTYEQYKNLKILPIIQEC
KIIGPGQNSLESYTASMQKALDLACKNNTTNIRKLSEIVG
>cas__F9CX58 Cas12 | cas | Type V effector | Nitrosarchaeum koreense MY1
MPFKIQYKFNDDPQIYHCVVSYAQYRNFCGLPIIQECKIIKGNETTTKKSLDEIQRALDLAYQKDTSHIRKLAENT
>acr__local__AcrIB2 AcrIB | acr | I-B | Clostridium dificile
MNKQKARRFLRVIDMNIDKIEEEAIKAFKESCLIKETNNIKIYIDIQGKVEAIAVQTWAKLLGDDKEINIFTLNQAPTHL
NDMLGEICYVNDYEEFENWCENEWENLDWDSYKKFNKENFEEIAERNIDDSTSVFLEELQKGIESCKQELQNVIEN
>acr__local__AcrIB3 AcrIB | acr | I-B | Listeria seeligeri
MKAIKLNVYLETANFRNPMSFQSKESYPLPPFSTVIGMVHVACGFKSYHAMDVSVAGNSFSTVHDLASRYEFNPTTKYES
ARHQMKVYSPQKDKMIGITQGISHIHLITDLHLQLHIIPEDQSEVYFIESKLKNPSQFLSLGRHEDVMMIKDVKVIDVQE
ETLPSNRELTKATYVPVSYKIGGAFFRLNKNYELVEQKKKWYRKFSKQEVLYAGEGTIIPKDSLIWVDEDGEVLFPV
>acr__local__AcrIB4 AcrIB | acr | I-B | Listeria seeligeri
MESVEKQAYEAGVTYRKKQLVSEGNYQTLVYKLTSIIKKGSKEAFVETLLDYSKVKRKQIPSVFQEDVMNEEKTFKSSAY
AFVIGLTQ
>acr__local__AcrIB5 AcrIB | acr | I-B | Listeria seeligeri
MAGFIKKYLDSRGWTIYQLGNATGLAHQTIRSADSKTVDQLSAKNVRLIAEVFHFTAGEILDEFYEIEEEITNDEILKEL
TTVFEKHGHNTDEISSELLDGETIKLDMTDDNITKLADAVNATEHFTAYLDSSTDYMIVEATQ
>acr__local__AcrIB6 AcrIB | acr | I-B | Listeria seeligeri
MGKTYWYNEGTDTLLTEKEYKELMEREAKALYEEVQEEEKDFESSEKTSFEEFLKTCYENESDFVLSDNEGNKLEEW
>acr__local__AcrIB7 AcrIB | acr | I-B | Listeria seeligeri
MRTFKMLLKKYNVEIKDVIQKGGIDKSSIYTLANKEKSKPDSSRITGAMLQSVALTVGIDPGTVINDLLYLEQEVGILAE
EMQNTLVNVIQTEGKEAALKFLPGFIFKVVEQEEFKEEFERYYSEFILAYKG
>acr__local__AcrIB8 AcrIB | acr | I-B | Listeria seeligeri
MKTIDRDEIAKDINACIKGLGRDIRTNWELGFEEGQIITLERYESWTTGGDFTVCNDCPVEYHFEIENEVPCHVVDYNNK
EEVIALGAEDCEDENEVLLPAGTKLEVVYGEHEDDNEEMGFYTVIFKYLEEEK
>acr__local__AcrIB9 AcrIB | acr | I-B | Listeria seeligeri
MNKFAFENDKYLERNIKAVVEKIARDFNLHLKSKYSKDCEFTVVADNSFDNIENSTIFLEIKRNDGKACQDHHIYAEYEC
DEDDNEYIALTVKFYGSSASNQINTVQGIKSSKYASCIVSDTDNQLSKSIHELNLKKEKEQQEAWNKKEAEYARKKQAYV
SQSQREKYEDIFDLPFDFYDYIDKKEQGLI
>acr__anti_CRISPR0494__AKG19229.1 AcrIC | acr | I-C | Moraxella bovoculi
MNNLKKTAITHDGVFAYKNTETVIGSVGRNDIVMAIDATHGEFNDKNFIIYADTNGNPIYLGYAYLDDNNDAHIDLAVGA
CNEDDDFDEKEIHEMIAEQMELAKRYQELGDTVHGTTRLAFDDDGYMTVRLDQQAYPDYRPENDDKHIMWRALALTATGK
ELEVFWLVEDYEDEEVNSWDFDIADDWREL
>acr__anti_CRISPR3668__WP_058130594.1 AcrIC | acr | I-C | Pseudomonas aeruginosa
MSIQVTSTNGRTVNLEIELGSVVASSGQVKFMADKTDRGLESRFLVPEAGNRRIEVALTGRDLEAANALFSELAASVEAT
NEMYRELDAERAQINKALEG
>acr__anti_CRISPR3670__WP_153575361.1 AcrIC | acr | I-C | Pseudomonas aeruginosa
MDNKITPADEEKIREWLNCEEASVDNDGDVWVAVPMTGHWLSDEQKAKYIEWRGDET
>acr__anti_CRISPR3672__SDK41378.1 AcrIC | acr | I-C | Pseudomonas delhiensis
MSKVTLNGQQIDFDAAVNLMDAELREELHSAQEWTNDQEFLDAYVQAHAAKFDGEEFQVA
>acr__anti_CRISPR3674__WP_080050315.1 AcrIC | acr | I-C | Pseudomonas sp. S-6-2
MTESLIHLRVPAATKGRWVRASRAVGLRLTDYITQAVEAYMQQQLTRVAIPDDIEFSDLKLARDPDGAVSFDWAVIERIC
HASGLPLEMMRDAPEDNVASLIIGWYQAHRADGGAADPVADDLIAEAMAEDAAGQQFSHQPGRA
>acr__anti_CRISPR3675__WP_003294373.1 AcrIC | acr | I-C | Pseudomonas stutzeri
MATVTKITLNGQNHYNFGSECSEADAEGYREWIAQELAENFPGAEIEINEADSTYSVVVEIDDESYYDEARGLKDDVNVF
CIDAWDRCPWDWVS
>acr__anti_CRISPR3677__WP_074202337.1 AcrIC | acr | I-C | Pseudomonas aeruginosa
MYAIRKIQFFYGPTDKKSYVGEEAGGRRELFKTRAEAQARIEDLEEGVYYLAHNESGRPDYKIVWVRGEAQFEHARWMRG
>acr__anti_CRISPR3679__ETD02882.1 AcrIC | acr | I-C | Rhodobacter capsulatus DE442
METKMTSFYKITAYNSQALYFWGTDADVDRYVDWLNRDREINVYAAEAIPEAEWAQYEGRDDVLSGEECGWDDFMSAEA
>acr__anti_CRISPR0434__YP_009272954.1 AcrID | acr | I-D | Sulfolobus islandicus rudivirus 3
MNYKELEKMLDVIFENSEIKEIDLFFDPEVEISKQEFEDLVKNADPLQKVVGDNYITETFEWWEFENQYLEFELDYYVKD
EKIFVLEMHFWRKIRK
>acr__anti_CRISPR0435__NP_666537.1 AcrID | acr | I-D | Sulfolobus islandicus rod-shaped virus 2
MKKMKFETLKNMINPVFENSEIWEVDLIFSEEIELTEDEYKDLTKNADPLQEIINDTTGVNIYTDTYEWWEFNNQYLELE
IDYYRQNDKIYLLELHFWRKVKK
>acr__anti_CRISPR0436__YP_009035089.1 AcrID | acr | I-D | Lactococcus phage P092
MIKAITMDSEELRNLLYIEYPESDINEIEVLDTVPEEEAETVVRELLVNYTEHGINYNDTVDIIVDDEPYYNDIPMKILF
DYMKDYGKTCFSIILKLTEEYYSDFLPLDTAQSANDITKTLIK
>acr__anti_CRISPR0437__YP_009036853.1 AcrID | acr | I-D | Lactococcus phage P078
MIKAITMDSEQLRNLLYIEYPESNIDEIEVLDTVPEEEAETVVRELLVNYTEHGINYNDTVDIIVDDEPYYNDIPMKVLF
DYMKDYGKTCFSIILKLTEEYYSDFLPLDTAQSANDITKTLIK
>acr__anti_CRISPR0438__YP_009035844.1 AcrID | acr | I-D | Lactococcus phage P118
MIKAITMDSEELRNLLYIEYPESNINEIEVLDTVPEEEAETVVRELLVNYTEHGINYNDTVDIIVDDEPYYNDIPMKVLF
DYMKDYGKTCFSIILKLTEEYYSDFLPLDTARSANDITKTMIK
>acr__anti_CRISPR0439__CAG28265.1 AcrID | acr | I-D | Sulfolobus islandicus rod-shaped virus 1
MNTQIKVESYVQEEVKVIFSEFEKFLRNKSSETKNIKYNSGFPVTSEELEDFLHEFWMIIGKELYENEVGNVYHAQFIVK
YKKIIVSVSFYFVKEDNIYKLVQVTFDKIFFGKLYELKRQLSQKKQ
>acr__anti_CRISPR0440__NP_666590.1 AcrID | acr | I-D | Sulfolobus islandicus rod-shaped virus 1
MQVEEMQEKVINLAQKYTNQKRFFRLIRKSNIAEKIIKEISEFYGIREDNIELFDNEIEFMFKKESVKLILKKQGNKLKI
ENIEMTKSIS
>acr__anti_CRISPR0441__NP_666586.1 AcrID | acr | I-D | Sulfolobus islandicus rod-shaped virus 2
MIDEKAQEKVINLSQKYVNSRKILAKVRRNRLERKIIKELAEFYGIRKDNIELFNNEIEFEFKRQYEIEDLKQEINVIVN
LKIRKENNKLKLLEVKLEKSITSNS
>acr__anti_CRISPR0407__YP_007392738.1 AcrIE | acr | I-E | Pseudomonas phage JBD5
MEKKLSDAQVALVAAWRKYPDLRESLEEAASILSLIVFQAETLSDQANELANYIRRQGLEEAEGACRNIDIMRAKWVEVC
GEVNQHGIRVYGDAIDRDVD
>acr__anti_CRISPR0409__YP_007392439.1 AcrIE | acr | I-E | Pseudomonas phage JBD88a
MNTYLIDPRKNNDNSGERFTVDAVDITAAAKSAAQQILGEEFEGLVYRETGESNGSGMFQAYHHLHGTNRTETTVGYPFH
VMEL
>acr__anti_CRISPR0408__YP_950454.1 AcrIE | acr | I-E | Pseudomonas phage DMS3
MKITNDTTTYEVAELMGSEADELDGRIMMGLLSRECVVDTDDLSEDQWLALIDESQKVRREQFESDEA
>acr__anti_CRISPR0410__NP_938238.1 AcrIE | acr | I-E | Pseudomonas phage D3112
MSTQYTYEQIAEDFRLWGEYMDPNAEMTEEEFQALSTEEKVAMQVEAFGAEA
>acr__anti_CRISPR0486__WP_064584002.1 AcrIE | acr | I-E | Pseudomonas citronellolis
MSTQYTYQQIAEDFRLWSEYVDTAGEMSKDEFNSLSTEDKVRLQVEAFGEEKSPKFSTKVTTKPDFDGFQFYIEAGRDFD
GDAYTEAYGVAVPTNIAARIQAQAAELNAGEWLLVEHEA
>acr__anti_CRISPR0487__WP_074973300.1 AcrIE | acr | I-E | Pseudomonas otitidis
MSNDRNGIINQIIDYTGTDRDHAERIYEELRADDRIYFDDSVGLDRQGLLIREDVDLMAVAAEIE
>acr__anti_CRISPR0488__WP_087937214.1 AcrIE | acr | I-E | Pseudomonas aeruginosa
MNNDTEVLEQQIKAFELLADELKDRLPTLEILSPMYTAVMVTYDLIGKQLASRRAELIEILEEQYPGHAADLSIKNLCP
>acr__anti_CRISPR0489__WP_087937215.1 AcrIE | acr | I-E | Pseudomonas aeruginosa
MIGSEKQVNWAKSIIEKEVEAWEAIGVDVREVAAFLRSISDARVIIDNRNLIHFQSSGISYSLESSPLNSPIFLRRFSAC
SVGFEEIPTALQRIRSVYTAKLLEDE
>acr__anti_CRISPR0001__YP_007392342.1 AcrIF | acr | I-F | Pseudomonas phage JBD30
MKFIKYLSTAHLNYMNIAVYENGSKIKARVENVVNGKSVGARDFDSTEQLESWFYGLPGSGLGRIENAMNEISRRENP
>acr__anti_CRISPR0006__NP_938237.1 AcrIF | acr | I-F | Pseudomonas phage D3112
MIAQQHKDTVAACEAAEAIAIAKDQVWDGEGYTKYTFDDNSVLIQSGTTQYAMDADDADSIKGYADWLDDEARSAEASEI
ERLLESVEEE
>acr__anti_CRISPR0003__YP_007392440.1 AcrIF | acr | I-F | Pseudomonas phage JBD88a
MSSTISDRIISRSVIEAARFIQSWEDADPDNLTESQVLAASSFAARLHEGLQATVLQRLVDESNRDEYREFQAWEEALLN
ADGRVTSNPFADWGWWYRIANVMLATASQNVGVAWGSHVHGRLMAIFQDRFQQHYEDEEC
>acr__anti_CRISPR0002__YP_007392799.1 AcrIF | acr | I-F | Pseudomonas phage JBD24
MMTISKTDIDCYLQTYVVIDPVSNGWQWGIDENGVGGALHHGRVEMVEGENGYFGLRGATHPTEKEAMAAALGYLWKCRQ
DLVAIARNDAIEAEKYRAKA
>acr__anti_CRISPR0005__YP_007392740.1 AcrIF | acr | I-F | Pseudomonas phage JBD5
MSRPTVVTVTETPRNPGSYEVNVERDGKMVVGRARAGSDPGAAAAKAMQMAMEWGSPNYVILGSNKVLAFIPEQLRVKM
>acr__anti_CRISPR0008__WP_043884810.1 AcrIF | acr | I-F | Pseudomonas aeruginosa
MKVPAFFAANILTIEQIIEAINNDGSAMTSAPEIAGYYAWDAATDALESENDLEQLTEDDFVAHLEVLEERGAKIDRDAA
IAVALQFQAAAVNDLHSGDE
>acr__anti_CRISPR0021__CCD58443.1 AcrIF | acr | I-F | Pseudomonas phage LPB1
MCLIWRHASHNGEAPTRIEAMTTFTSIVTTNPDFGGFEFYVEAGQQFDDSAYEEAYGVSVPTAVVEEMNAKAAQLKDGEW
LNVSHEA
>acr__anti_CRISPR0034__AFC22483.1 AcrIF | acr | I-F | Pectobacterium phage ZF40
MARIAPNEDSTMSTAYIIFNSSVAAVVDTEIANGANVTFSTVTVKEEINANRDFNLVNAQNGKISRAKRWGNEASKCEYF
GREINPTEFFIK
>acr__anti_CRISPR0133__EFG02164.1 AcrIIA | acr | II-A | Listeria monocytogenes FSL J1-194
MSIKLLDEFLKKHNKTRYQLSKLTGISQNTLNDYNKKELNKYSVSFLRALSMCTGISTFDVFIELAELEKNYDDLAGFKH
LLDKYKLSFPAQEFELYCLIKEFECANIEVLPFTFNRFENETHVDIEKDVRKALENAITVLKEKKNELI
>acr__anti_CRISPR0245__EFG02165.1 AcrIIA | acr | II-A | Listeria monocytogenes FSL J1-194
MTITTAQKRYYDAMNEFEAIISKELEQTPAFSQDLLNDSDYLAVTKNEAYAVALCLLDDDKLYLDETLVHSTRLDIEDET
YYINFVVTNEDDFKLATDEDKEKHDKQEVIIKSGLN
>acr__anti_CRISPR0331__EFG02166.1 AcrIIA | acr | II-A | Listeria monocytogenes FSL J1-194
MYNKAEIMKQAWNWFNDSNIWLSDIEWVSYTDKEKSFSVCLKAAWSKAKEEVEESKKESKHIAKSEELKAWNWAERKLGL
HFNISDDEKFTSVKDETKINFGLSLWACAMKAVKLHNDLFPQTAA
>acr__anti_CRISPR0384__AEO04689.1 AcrIIA | acr | II-A | Listeria monocytogenes J0161
MNINDLIREIKNKDYTVKLSGTDSNSITQLIIRVNNDGNEYVISESENESIVEKFISAFKNGWNQEYEDEEEFYNDMQTI
TLKSELN
>acr__anti_CRISPR0433__ASD50988.1 AcrIIA | acr | II-A | Streptococcus phage D4276
MAYGKSRYNSYRKRSFNRSNKQRREYAQEMDRLEKAFENLDGWYLSSMKDSAYKDFGKYEIRLSNHSADNKYHDLENGRL
IVNIKASKLNFVDIIENKLDKIIEKIDKLDLDKYRFINATNLEHDIKCYYKGFKTKKEVI
>acr__anti_CRISPR1284__AVO22749.1 AcrIIA | acr | II-A | Streptococcus phage D1811
MKINDDIKELILEYMSRYFKFENDFYKLPGIKFTDANWQKFKNGGTDIEKMGAARVNAMLDCLFDDFELAMIGKAQTNYY
NDNSLKMNMPFYTYYDMFKKQQLLKWLKNNRDDVIGGTGRMYTASGNYIANAYLEVALESSSLGSGSYMLQMRFKDYSKG
QEPIPSGRQNRLEWIENNLENIR
>acr__anti_CRISPR0558__VDB32354.1 AcrIIA | acr | II-A | metagenome
MTFGQALESLKRGHLVARKGWNGKGMFIFMRPEDSLPTNMIVNQVKSLPESFKRWVANNHGDSETDRIKFTAYLCMKAAD
GTIVNGWLASQTDMLANDWVIVE
>acr__anti_CRISPR0559__VDB32352.1 AcrIIA | acr | II-A | metagenome
MSIFTDMIPAELLINEYKKGQSGAKHDNYVSVGRIMVAIYKNNSFKNTGTVKYQDSTHSGITMSKVFIDGKEYRIDIDTQ
HYEVQDFDTSGRQTTLILKRIDLYG
>acr__anti_CRISPR0052__WP_028357638.1 AcrIIC | acr | II-C | Brackiella oedipodis
MKEVFKLKPELVTYKGCGWALACIKDGEIIDLTYVRDLGIEEYDENFDGLEPEIIYYDVVASQACKEVAYRYEEMGEFTF
GLCSCWEFNVM
>acr__anti_CRISPR0053__ADV02121.1 AcrIIC | acr | II-C | Alicycliphilus denitrificans BC
MNVYPVPDSFAGNYGVGYALAAIAGGQVLSLKYIAEHVDEKTQDELAEGGAPARNAAFKWIGSQSAGPVVRELQALGRVC
AGMCSGWEFVEL
>acr__anti_CRISPR0063__WP_042743678.1 AcrIIC | acr | II-C | Neisseria meningitidis
MSKNNIFNKYPTIIHGEARGENDEFVVHTRYPRFLARKSFDDNFTGEMPAKPVNGELGQIGEPRRLAYDSRLGLWLSDFI
MLDNNKPKNMEDWLGQLKAACDRIAADDLMLNEDAADLEGWDD
>acr__anti_CRISPR0064__CWP55982.1 AcrIIC | acr | II-C | Neisseria meningitidis
MAAFLKGFKMSKNNIFNKYPTIIHGEARGENDEFVVHTRYPRFLARKSFDDNFTGGIPAKPVNGELGQIGEPRRLAYDSR
LGLWLSDFIMLDNNKPESMEDWLGQLKAACDRIAADDLMLNEDAAALEGWDD
>acr__anti_CRISPR0119__WP_042743676.1 AcrIIC | acr | II-C | Neisseria meningitidis
MFKRAIIFTSFNGFEKVSRTEKRRLAKIINARVSIIDEYLRAKDTNASLDGQYRAFLFNDESPAMTEFLAKLKAFAESCT
GISIDAWEIEESEYVRLPVERRDFLAAANGKEIFKI
>acr__anti_CRISPR0120__WP_002231708.1 AcrIIC | acr | II-C | Neisseria meningitidis
MFKRAIIFTSFNGFEKVSRTEKRQLAKIINSEVSIINEHLEAKATNASLDGQYRAFLFNDESPAMTELLAKLKAFAESCT
GISIDAWEIEESEYVRLPVERRDFLAAANGKEIFKI
>acr__anti_CRISPR0553__WP_049372635.1 AcrIIC | acr | II-C | Haemophilus parainfluenzae
MKITSSNFATIATSENFAKLSVLPKNHREPIKGLFKSAVEQFSSARDFFKNENYSKELAEKFNKEAVNEAVEKLQKAIDL
AEKQGIQF
>acr__anti_CRISPR0554__WP_002642161.1 AcrIIC | acr | II-C | Simonsiella muelleri
MNNSIKFHVSYDGTARALFNTKEQAEKYCLVEEINDEMNGYKRKSWEEKLREENCASVQDWVEKNYTSSYSDLFNICEIE
VSSAGQLVKIDNTEVDDFVENCYGFTLEDDLEEFNKAKQYLQKFYAECEN
>acr__anti_CRISPR0495__AKG19227.1 AcrVA | acr | V-A | Moraxella bovoculi
MYEAKERYAKKKMQENTKIDTLTDEQHDALAQLCAFRHKFHSNKDSLFLSESAFSGEFSFEMQSDENSKLREVGLPTIEW
SFYDNSHIPDDSFREWFNFANYSELSETIQEQGLELDLDDDETYELVYDELYTEAMGEYEELNQDIEKYLRRIDEEHGTQ
YCPTGFARLR
>acr__anti_CRISPR3606__AKG07173.1 AcrVA | acr | V-A | Moraxella bovoculi
MSETIQEQGLELDLDDDATYELVYDELYTEAMAEYEKLNQDIEKYLRRIDEEYGTQYCPTGFARLR
>acr__anti_CRISPR3610__EGE16485.1 AcrVA | acr | V-A | Moraxella catarrhalis BC1
MIEYNSKPQKAINFIIDTDSDDDIYLPLTLILDDDMTVEQSLSYADNNIGDGGSNELIKILLPYLLWLCVAEPEIMHKGE
PVSRANLDKPKYQTNKKTGVFIPPSEPFIYEVGSRLGGEIRHYQEQIEQGKHRQTSKKRPHIRRGHWHGHWHGTGQAKEF
KIKWQPAIFVNAGV
>acr__anti_CRISPR3611__EGE16486.1 AcrVA | acr | V-A | Moraxella catarrhalis BC1
MHRTIARMHKFNKEFTNAKECYKKMQQAYLASKNKFAFFPMQHASLLDMSTAIAYEQTRSDPFSEKGVNALKTLNQLYLF
GTWRYTLGIYCLDSEIIKDSKAIPNDTPTSIF
>acr__anti_CRISPR0497__AKG19230.1 AcrVA | acr | V-A | Moraxella bovoculi
MVGKSKIDWQSIDWTKTNAQIAQECGRAYNTVCKMRGKLGKSHQGAKSPRKDKGISRPQPHLNRLEYQALATAKAKASPK
AGRFETNTKAKTWTLKSPDNKTYTFTNLMHFVRTNPHLFDPDDVVWRTKSNGVEWCRASSGLALLAKRKKAPLSWKGWRL
ISLTKDNK
>acr__anti_CRISPR0501__OOR90252.1 AcrVA | acr | V-A | Moraxella caviae
MIAHQKNRRADWESVDWTKHNDEIAQLLSRHPDSVAKMRTKFGAQGMAKRKPRRKYKVTRKAVPPPHTQELATAAAKISP
KSGRYETNVNAKRWLIISPSGQRFEFSNLQHFVRNHPELFAKADTVWKRQGGKRGTGGEYCNASNGLAQAARLNIGWKGW
QAKIIKG
>acr__anti_CRISPR0556__WP_046699156.1 AcrVA | acr | V-A | Moraxella bovoculi
MYEIKLNDTLIHQTDDRVNAFVAYRYLLRRGDLPKCENIARMYYDGKVIKTDVIDHDSVHSDEQAKVSNNDIIKMAISEL
GVNNFKSLIKKQGYPFSNGHINSWFTDDPVKSKTMHNDEMYLVVQALIRACIIKEIDLYTEQLYNIIKSLPYDKRPNVVY
SDQPLDPNNLDLSEPELWAEQVGECMRYAHNDQPCFYIGSTKRELRVNYIVPVIGVRDEIERVMTLEEVRNLHK
>acr__anti_CRISPR0557__WP_046699157.1 AcrVA | acr | V-A | Moraxella bovoculi
MKIELSGGYICYSIEEDEVTIDMVEVTTKRQGIGSQLIDMVKDVAREVGLPIGLYAYPQDDSISQEDLIEFYFSNDFEYD
PDDVDGRLMRWS
>acr__anti_CRISPR3657__ERK51680.1 AcrVIA | acr | VI-A | Leptotrichia wadei F0279
MEKIKLICLRINNDELITTDKDEWLKFIKRHRGKVSSIEQFNWKIPGNKLQKALEYSFDELYKFKQKENRRETD
>acr__anti_CRISPR3658__ERK51681.1 AcrVIA | acr | VI-A | Leptotrichia wadei F0279
MWKCKKCGCDRFYQDITGGISEVLEMDKDGEVLDEIDDVEYGDFSCAKCDNSSSKIQEIAYWDEINGKNKTYLSKDK
>acr__anti_CRISPR3659__ERK48335.1 AcrVIA | acr | VI-A | Leptotrichia wadei F0279
MFKEFLEKCLRYGNLYILEETGDRKKVKRISKRHGKVTEASVLLFDSGTKRTTINEIYLNSQGYFIIRDQKRLKLEKFK
>acr__anti_CRISPR3660__ERK48333.1 AcrVIA | acr | VI-A | Leptotrichia wadei F0279
MDKANRCLKAKDKILNILEKEEITLDEFNNISKDIAKEYVEKAVLKPKDIAERIINMVKNAKSISFDELASEISEE
>acr__anti_CRISPR3661__ERK48092.1 AcrVIA | acr | VI-A | Leptotrichia wadei F0279
MERNFKKVTENTGRKEVFKVMHDKVEIINDFNTNEKREARIIFHDQKIYVILYQNLNFEELKWLNFYILIYGNQSYGKNT
FFEFKLNKNNLIYHLQVWNIIENKKFKSKSISLLVKALSSKAGV
>acr__anti_CRISPR3662__ETD74580.1 AcrVIA | acr | VI-A | Rhodobacter capsulat R121
MADKVKSIQPGPIFYDVFLVYLRVIGTNLKDWCAPHGVTATNAKSAATGGWNGTKARALRQKMIDEVGEETFLRLYTERL
RREAA
>acr__anti_CRISPR3663__ACV38861.1 AcrVIA | acr | VI-A | Leptotrichia buccalis C-1013-b
MRIIKLYERIIPKTSSTSYISRWEALNIPDENRNTAAWHPRTYLFSYDKDKAINLYNTTNVLGNSGIKKRIIDYPSKREV
YIANFPRAIADLVLTMKDYQLSSLHNCCNDFFNEDETEQLYQYLRSIKDNRRVDEFLKYEFTVRYFNDKKF
>acr__anti_CRISPR0411__WP_013997274.1 AcrVIB | acr | VI-B | Capnocytophaga canimorsus
MDRLSIYELLSFVVPGVIMIELINFSAEYVFGKDRLITAGNLSDGLLFFAIALFIGCLIHIITFRLIKRKWYKKLAYKPI
NEIENNAYIKQIFTTLKEEYSKIHNINSIDEISKLNIFEAVITT
>acr__anti_CRISPR0412__WP_044218241.1 AcrVIB | acr | VI-B | Phaeodactylibacter xiamenensis
MDEGTLLINILTGPAKDKPLWFEFIGIGVTISLAAWGYLRAFGAWEKQKKRELELQHKQRKLEIKLQFEKQRYEHELKAA
EGVWPLLAYFSLWENDKSVFVKRGDHWYFRQEQGREYILALSENFFNKGYGVFMPGPAKENLYHFRGMIYKLLQDSKSNG
NDNNEVLLKNQSMVQKKDKQAAPNKKSVEQLKDEINASLRNMLQKSEIDLD
>acr__anti_CRISPR0413__WP_021665476.1 AcrVIB | acr | VI-B | Porphyromonas gingivalis
MEKFSLYDFLAIILPGIAFIVVFRIIFSSLHLSLPVDIPLGLESTIVYALICGAVLYVLSFSLVKLFPRLFGLYRHVADL
YQKMKALHPIMNDTLNRQAERWGLGKIYLSEEEFCQSEEKEKIRMLQSDFYDRMWYRLDFRGKLGSAKSFQCYYFFFRHS
FWGLVLISLILLSYKLLAYIPACDMEDIGRREYSDIAVPIMILSALFVFLAQWFRIKMVEKMYWTFYISLIEQENSNL
>acr__anti_CRISPR0414__WP_012458152.1 AcrVIB | acr | VI-B | Porphyromonas gingivalis
MEKFSLYDFLAIILPGIAFIVVFRIIFSSLHLSLPVDIPLGLESTIVYALICGAVLYVLSFSLVKLFPRLFGLYRHVADL
YQKMKALHPIMNDTLNRQAEQWGLGKIYLSEEEFCQSEEKEKIRMLQSDFYDRMWYRLDFRGKLGNAKSFQCYYFFFRHS
FWGLVLISLILLSYKLLAYIPACDMEDIGWREYSDIAVPIMILSALFVFLAQWFRIKMVEKMYWTFYISLIEQENSNL
>acr__anti_CRISPR0415__ERJ81988.1 AcrVIB | acr | VI-B | Porphyromonas gingivalis F0185
MEKFSLYDFLAIILPGIAFIVVFRIIFSSLHLSLPVDIPLGLESTIVYALICGAVLYVLSFSLVKLFPRLFGLYRHVADL
YQKMKALHPIMNDTLNRQAERWGLGKIYLSEEEFCQSEEKEKIRMLQSDFYDRMWYRLDFRGKLGNAKSFQCYYFFFRHS
FWGLVLISLILLSYKLLAYIPACDMEDIGWREYSDIAVPIMILSALFVFLAQWFRIKMVEKMYWTFYISLIEQENSNL
>acr__anti_CRISPR0417__ERJ65638.1 AcrVIB | acr | VI-B | Porphyromonas gingivalis F0568
MEKFSLYDFLAIILPGIAFIVVFRIIFSSLHLSLPVDIPLGLESTIVYALICGAVLYVLSFSLVKLFPRLFGLYRHVADL
YQKMKALHPIMNDTLNRQAEQWGLGKIYLSEEEFCQSEEKEKIRMLQSDFYDRMWYRLDFRGKLGSAKSFQCYYFFFRHS
FWGLVLISLILLSYKLLAYIPACDMEDIGWREYSDIAVPIMILSALFVFLAQWFRIKMVEKMYWTFYISLIEQENSNL
>acr__anti_CRISPR0418__ERJ87336.1 AcrVIB | acr | VI-B | Porphyromonas gingivalis W4087
MEKFSLYDFLAIILPGIAFIVVFRIIFSSLHLSLPVDIPLGLESTIVYALICGAVLYVLSFSLVKLFPRLFGLYRHVADL
YQKMKALHPIMNDTLNRQAERWGLGKIYLSEEEFCQSEEKEKIRMLQSDFYDRMWYRLDFRGKLGSAKSFQCYYFFFRHS
FWGLVLISLILLSYKLLAYIPACDMEDIGWREYSDIAVPIMILSALFVFLAQWFRIKMVEKMYWTFYISLIEQENSNL
>acr__anti_CRISPR0421__WP_039445052.1 AcrVIB | acr | VI-B | Porphyromonas gulae
MEKFSLYDFLAIILPGIAFIVVFRVVFSSLHLSLPVDIPLDLEFTIVYALICGAVLYVLSFSLVKLFPRLFGLYRHVADL
YQRMKALHPIMNDTLNRQAEQWGLGRIYLSEEEYCRSEEKEKIRMLQSDFYNRMWYRLDFRGKLGNAKSFQCYYFFFRHS
FLGLVLISLILLSYKLLAYIPACELEDIGWKEYSDIAVPIIILSVLFVFLAQWFRIKMVEKMYWTFYISLIEQENSNL