[
    {"drug": "fluoxetine", "brand_names": ["Prozac"], "class": "SSRI", "typical_dose": "20-80mg daily", "common_side_effects": ["nausea", "insomnia", "sexual dysfunction", "headache"], "serious_side_effects": ["serotonin syndrome", "suicidality in <25"], "notes": "Long half-life. FDA approved for adolescents."},
    {"drug": "sertraline", "brand_names": ["Zoloft"], "class": "SSRI", "typical_dose": "50-200mg daily", "common_side_effects": ["nausea", "diarrhea", "insomnia", "sexual dysfunction"], "serious_side_effects": ["serotonin syndrome", "suicidality in <25"], "notes": "Most safety data in pregnancy. Common first-line choice."},
    {"drug": "escitalopram", "brand_names": ["Lexapro"], "class": "SSRI", "typical_dose": "10-20mg daily", "common_side_effects": ["nausea", "insomnia", "sexual dysfunction"], "serious_side_effects": ["QT prolongation", "serotonin syndrome"], "notes": "Most selective SSRI. Well-tolerated."},
    {"drug": "paroxetine", "brand_names": ["Paxil"], "class": "SSRI", "typical_dose": "20-50mg daily", "common_side_effects": ["weight gain", "sedation", "sexual dysfunction", "dry mouth"], "serious_side_effects": ["severe discontinuation syndrome", "teratogenic"], "notes": "Avoid in pregnancy. Short half-life."},
    {"drug": "citalopram", "brand_names": ["Celexa"], "class": "SSRI", "typical_dose": "20-40mg daily", "common_side_effects": ["nausea", "drowsiness", "dry mouth"], "serious_side_effects": ["dose-dependent QT prolongation"], "notes": "Max 40mg. Max 20mg in >60 or hepatic impairment."},
    {"drug": "venlafaxine", "brand_names": ["Effexor XR"], "class": "SNRI", "typical_dose": "75-375mg daily", "common_side_effects": ["nausea", "headache", "insomnia", "sweating", "elevated BP"], "serious_side_effects": ["hypertension", "serotonin syndrome", "severe discontinuation"], "notes": "Monitor BP. Norepinephrine effect >150mg."},
    {"drug": "duloxetine", "brand_names": ["Cymbalta"], "class": "SNRI", "typical_dose": "60-120mg daily", "common_side_effects": ["nausea", "dry mouth", "constipation", "fatigue"], "serious_side_effects": ["hepatotoxicity", "serotonin syndrome"], "notes": "Dual indication: depression + chronic pain."},
    {"drug": "bupropion", "brand_names": ["Wellbutrin XL", "Wellbutrin SR"], "class": "NDRI", "typical_dose": "150-450mg daily", "common_side_effects": ["insomnia", "dry mouth", "headache", "agitation"], "serious_side_effects": ["seizure risk (dose-dependent)"], "notes": "No sexual side effects. Weight-neutral. Contraindicated in seizure disorders, bulimia/anorexia."},
    {"drug": "mirtazapine", "brand_names": ["Remeron"], "class": "NaSSA", "typical_dose": "15-45mg daily", "common_side_effects": ["sedation", "weight gain", "increased appetite"], "serious_side_effects": ["agranulocytosis (rare)"], "notes": "Sedating at lower doses. Good for insomnia and poor appetite."},
    {"drug": "esketamine", "brand_names": ["Spravato"], "class": "NMDA antagonist", "typical_dose": "56-84mg intranasal", "common_side_effects": ["dissociation", "dizziness", "nausea", "sedation", "increased BP"], "serious_side_effects": ["abuse potential (Schedule III)", "dissociative symptoms"], "notes": "FDA approved for TRD (2019) and as monotherapy (2025). Certified settings only. 2-hour observation required."}
]