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core/__pycache__/agent.cpython-313.pyc CHANGED
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core/__pycache__/tools.cpython-313.pyc CHANGED
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core/agent.py CHANGED
@@ -166,13 +166,13 @@ Your primary purpose is to provide evidence-based clinical guidance on lung canc
166
 
167
  **PART 1: INLINE CITATIONS** - Add a citation immediately after EACH section or statement in your answer:
168
  * After each clinical statement, recommendation, or data point, add an inline citation in parentheses
169
- * Format: (Source: [source name without file extension], Page: [page number], Provider: [provider])
170
- * Example: "Local authorities must use coordinated campaigns to raise awareness (Source: NICE, Page: 6, Provider: NICE)."
171
  * If a section uses multiple pages, cite each: "Structure measures include... (Page: 6). Process measures include... (Page: 15). Outcome measures include... (Page: 8)."
172
 
173
  **PART 2: COMPREHENSIVE CITATION LIST AT END** - After your complete answer, add a section titled "**References**" that lists ALL pages cited:
174
- * Format: (Source: [source name without file extension], Pages: [all page numbers in order], Provider: [provider name], Location: [specific sections/tables used])
175
- * Example: (Source: NICE, Pages: 6, 8, 15, Provider: NICE, Location: Quality Statement 1 - Structure, Process, and Outcome measures)
176
 
177
  - **PAGE CITATION RULE - EXTREMELY IMPORTANT**:
178
  * BEFORE writing your answer, review ALL retrieved pages (including context pages) and identify EVERY page that contains information you will use
 
166
 
167
  **PART 1: INLINE CITATIONS** - Add a citation immediately after EACH section or statement in your answer:
168
  * After each clinical statement, recommendation, or data point, add an inline citation in parentheses
169
+ * Format: (Source: [Provider + full document title without file extension], Page: [page number], Provider: [provider])
170
+ * Example: "Local authorities must use coordinated campaigns to raise awareness (Source: NICE Systemic anti-cancer therapy for advanced non‑small‑cell lung cancer, Page: 6, Provider: NICE)."
171
  * If a section uses multiple pages, cite each: "Structure measures include... (Page: 6). Process measures include... (Page: 15). Outcome measures include... (Page: 8)."
172
 
173
  **PART 2: COMPREHENSIVE CITATION LIST AT END** - After your complete answer, add a section titled "**References**" that lists ALL pages cited:
174
+ * Format: (Source: [Provider + full document title without file extension], Pages: [all page numbers in order], Provider: [provider name], Location: [specific sections/tables used])
175
+ * Example: (Source: NICE Systemic anti-cancer therapy for advanced non‑small‑cell lung cancer, Pages: 6, 8, 15, Provider: NICE, Location: Quality Statement 1 - Structure, Process, and Outcome measures)
176
 
177
  - **PAGE CITATION RULE - EXTREMELY IMPORTANT**:
178
  * BEFORE writing your answer, review ALL retrieved pages (including context pages) and identify EVERY page that contains information you will use
core/tools.py CHANGED
@@ -184,6 +184,10 @@ def _build_citation(index: int, metadata: dict, content: str, include_provider:
184
  source = os.path.splitext(source)[0]
185
  page = metadata.get("page_number", "?")
186
  provider = metadata.get("provider", "unknown")
 
 
 
 
187
  disease = metadata.get("disease", "unknown")
188
  is_context = metadata.get("context_enrichment", False)
189
 
 
184
  source = os.path.splitext(source)[0]
185
  page = metadata.get("page_number", "?")
186
  provider = metadata.get("provider", "unknown")
187
+ # Ensure source displays as "<PROVIDER> <file-stem>" unless it already starts with the provider
188
+ if isinstance(source, str) and isinstance(provider, str) and provider and source:
189
+ if not source.lower().startswith(provider.lower()):
190
+ source = f"{provider} {source}"
191
  disease = metadata.get("disease", "unknown")
192
  is_context = metadata.get("context_enrichment", False)
193
 
data/medical_terms_cache.json CHANGED
@@ -4,60 +4,60 @@
4
  "esmo"
5
  ],
6
  "esmo": [
 
7
  "the european society for medical\noncology",
 
8
  "european society of medical oncology",
9
- "european society for medical oncology",
10
  "european society for\nmedical oncology",
11
- "the european society for medical oncology",
12
- "european\nsociety of medical oncology"
13
  ],
14
  "american society of clinical\n\noncology": [
15
  "asco"
16
  ],
17
  "asco": [
18
  "american society of clinical\n\noncology",
19
- "american society of clinical oncology",
20
- "american\nsociety of clinical oncology",
21
  "s note\n\nthis american society of clinical oncology",
22
- "md american society of clinical oncology",
23
  "journal of clinical oncology",
24
- "inc"
 
 
 
25
  ],
26
  "italian association of medical oncology": [
27
  "aiom"
28
  ],
29
  "aiom": [
30
- "italian association\nof medical oncology",
31
- "italian association of medical oncology"
32
  ],
33
  "national comprehensive cancer network": [
34
  "nccn"
35
  ],
36
  "nccn": [
37
  "national comprehensive cancer network",
38
- "leading american cancer centers",
39
- "vs insurance-based"
40
  ],
41
  "non-small cell lung cancer": [
42
  "nsclc"
43
  ],
44
  "nsclc": [
45
- "e-mutant advanced non-small cell lung cancer",
46
- "advanced non-small cell lung cancer",
47
- "robotic lobectomy for non-small cell lung cancer",
48
  "non-small-cell lung cancer",
 
49
  "small cell lung cancer",
50
- "mutant advanced non-small cell lung cancer",
51
- "advanced non-small-cell lung cancer",
52
  "small-cell\nlung cancer",
53
- "small-cell lung cancer",
54
- "iii non-small-cell lung cancer",
55
- "stage iii non small cell lung cancer",
56
  "lung cancer",
57
  "non-small cell lung cancer",
 
58
  "cancer",
 
59
  "small cell\nlung cancer",
60
- "-rearranged advanced non-small-cell lung cancer"
 
 
 
 
61
  ],
62
  "american\nsociety of clinical oncology": [
63
  "asco"
@@ -76,19 +76,19 @@
76
  ],
77
  "glides": [
78
  "guidelines into decision support",
79
- "using the guidelines into decision support",
80
- "using the guidelines into decision\nsupport"
81
  ],
82
  "for all the newly\neuropean medicines agency": [
83
  "ema"
84
  ],
85
  "ema": [
86
- "european medicines agency",
87
- "and the european medicines agency",
88
- "and the european medicines\nagency",
89
  "for all the newly\neuropean medicines agency",
 
 
90
  "not european medicines agency",
91
- "for all the newly european medicines agency"
 
92
  ],
93
  "evaluates treatments with curative intent": [
94
  "such\nas adjuvant chemotherapy",
@@ -131,10 +131,10 @@
131
  "bsc"
132
  ],
133
  "bsc": [
134
- "or best supportive\ncare",
135
- "leads to\nincreased dfs versus best supportive care",
136
  "or best supportive care",
137
- "leads to increased dfs versus best supportive care"
 
 
138
  ],
139
  "author affiliations\nand support\n\ninformation": [
140
  "if\n\napplicable"
@@ -152,17 +152,17 @@
152
  "rcts"
153
  ],
154
  "rcts": [
 
155
  "clinical trials",
156
- "two randomized control trials",
157
- "controlled trials"
158
  ],
159
  "the primary end point was disease-free\nsurvival": [
160
  "dfs"
161
  ],
162
  "dfs": [
163
- "the primary end point was disease-free survival",
164
  "disease-free survival",
165
- "the primary end point was disease-free\nsurvival"
 
166
  ],
167
  "joint cancer care ontario": [
168
  "cco"
@@ -177,75 +177,75 @@
177
  "inst"
178
  ],
179
  "inst": [
 
 
 
 
180
  "crispr\ntherapeutics",
181
- "merck",
182
- "trizell",
183
- "anheart therapeutics",
184
- "inc",
185
- "regeneron",
186
- "bms",
187
- "bristol-myers squibb",
188
- "lilly",
189
- "oric pharmaceuticals",
190
- "elevation oncology",
191
- "amgen",
192
- "janssen oncology",
193
- "verastem",
194
- "medimmune",
195
  "black diamond therapeutics",
196
- "janssen",
197
  "msd",
 
 
 
 
 
 
 
 
198
  "guardant health",
199
- "palobiofarma",
200
- "constellation pharmaceuticals",
201
- "neogenomics",
202
- "blueprint medicines",
203
- "nuvation bio",
 
 
 
 
 
204
  "pfizer",
205
- "therapeutics",
206
- "gsk",
 
207
  "pharmamar",
208
- "mirati therapeutics",
209
- "glaxosmithkline",
210
- "revolution medicines",
211
- "dohme",
212
- "crispr therapeutics",
213
  "summit therapeutics",
214
- "harpoon therapeutics",
215
- "macrogenics",
216
- "jazz pharmaceuticals",
217
- "glaxosmithkline canada",
218
- "genentech",
219
  "takeda",
220
- "astra zeneca",
221
- "cullinan oncology",
222
  "abbvie",
223
- "bristol myers\nsquibb",
224
  "dizal\npharma",
 
 
 
 
225
  "puma biotechnology",
226
- "advaxis",
227
- "novartis",
 
228
  "vivace therapeutics",
229
- "turning point therapeutics",
230
- "astex pharmaceuticals",
231
- "merck serono",
232
- "oncomed",
233
- "astrazeneca",
234
- "exelixis",
235
  "bayer",
236
- "dizal pharma",
237
- "inhibrx",
238
- "calithera biosciences",
239
- "polaris",
240
- "arcus biosciences",
241
- "astrazeneca canada",
242
- "black diamond\ntherapeutics",
243
  "boehringer ingelheim",
244
- "sutro biopharma",
245
- "bristol myers squibb",
246
- "forward",
247
- "roche",
248
- "bristol myers squibb foundation"
 
 
 
 
249
  ],
250
  "pfizer": [
251
  "inst"
@@ -254,8 +254,8 @@
254
  "inst"
255
  ],
256
  "bristol-myers squibb": [
257
- "bms",
258
- "inst"
259
  ],
260
  "medimmune": [
261
  "inst"
@@ -304,18 +304,18 @@
304
  "continued"
305
  ],
306
  "continued": [
307
- "medical guideline document - esmo open references",
308
  "the bottom line",
309
- "all recommendations"
310
  ],
311
  "salvage stereotactic body radiation therapy": [
312
  "sbrt"
313
  ],
314
  "sbrt": [
 
315
  "salvage stereotactic body radiation therapy",
316
- "fdg-pet and stereotactic body radiotherapy",
317
  "sabr or stereotactic body radiotherapy",
318
- "stereotactic body radiotherapy"
319
  ],
320
  "oncomed": [
321
  "inst"
@@ -330,35 +330,35 @@
330
  "cap"
331
  ],
332
  "cap": [
333
- "the college of american pathologists",
334
- "thecollege of americanpathologists"
335
  ],
336
  "association\nfor molecular pathology": [
337
  "amp"
338
  ],
339
  "amp": [
340
- "association\nfor molecular pathology",
341
- "association for molecular pathology"
342
  ],
343
  "and anaplastic lymphoma kinase": [
344
  "alk"
345
  ],
346
  "alk": [
347
- "phoma kinase",
348
- "and anaplastic lymphoma kinase",
349
  "crizotinib-pretreated anaplastic lymphoma kinase",
350
- "positive anaplastic lymphoma kinase"
 
 
351
  ],
352
  "immunohistochemistry": [
353
  "ihc"
354
  ],
355
  "ihc": [
356
- "egfr fish or immunohistochemistry",
357
- "immunohistochemistry"
358
  ],
359
  "merck": [
360
- "german",
361
- "inst"
362
  ],
363
  "glaxosmithkline": [
364
  "gsk",
@@ -371,8 +371,8 @@
371
  "inst"
372
  ],
373
  "bristol myers\nsquibb": [
374
- "bms",
375
- "inst"
376
  ],
377
  "polaris": [
378
  "inst"
@@ -411,8 +411,8 @@
411
  "icis"
412
  ],
413
  "icis": [
414
- "immune checkpoint inhibitors",
415
- "neoadjuvant immune checkpoint inhibitors"
416
  ],
417
  "american society of clinical oncology": [
418
  "asco"
@@ -433,13 +433,13 @@
433
  "inst"
434
  ],
435
  "bms": [
436
- "bristol-myers squibb",
437
  "inst",
 
438
  "bristol myers\nsquibb",
 
439
  "celgene",
440
- "bristol\nmyers squibb",
441
- "bristol myers squibb",
442
- "bristol-myers\nsquibb"
443
  ],
444
  "trizell": [
445
  "inst"
@@ -457,27 +457,27 @@
457
  "rct"
458
  ],
459
  "rct": [
460
- "one randomized controlled trial",
461
  "phase iib randomised controlled trial",
462
- "phase iii randomised clinical trial",
463
  "a phase iii randomised clinical trial",
464
- "phase iib\nrandomised controlled trial"
 
465
  ],
466
  "the primary end point of progression-free survival": [
467
  "pfs"
468
  ],
469
  "pfs": [
470
- "the median progression-free\nsurvival",
471
- "progression-free survival",
472
- "and\nprogression-free survival",
473
- "the median progression-free survival",
474
  "and progression-free survival",
475
- "no\nimprovement in progression-free survival",
476
  "quality of life and progression-free survival",
477
- "the median\nprogression-free survival",
478
- "the primary end point of progression-free survival",
479
  "reported improved\nprogression-free survival",
480
- "reported improved progression-free survival"
 
 
 
 
 
481
  ],
482
  "adverse events": [
483
  "aes",
@@ -485,8 +485,8 @@
485
  ],
486
  "aes": [
487
  "mainly altered lipid levels",
488
- "adverse events",
489
- "adverse\nevents"
490
  ],
491
  "and consolidation": [
492
  "for unresectable stage iii nsclc"
@@ -498,13 +498,13 @@
498
  "osimertinib"
499
  ],
500
  "osimertinib": [
501
- "treatment is now an\negfr-targeted drug",
502
  "osi",
503
- "treatment is now an egfr-targeted drug"
504
  ],
505
  "inc": [
506
- "asco",
507
- "inst"
508
  ],
509
  "small cell\nlung cancer": [
510
  "nsclc"
@@ -519,8 +519,8 @@
519
  "vegf"
520
  ],
521
  "vegf": [
522
- "and vascular endothelial growth factor",
523
- "and vascular\nendothelial growth factor"
524
  ],
525
  "though rates of\nimmune-related aes": [
526
  "iraes"
@@ -530,15 +530,15 @@
530
  "though rates of immune-related aes"
531
  ],
532
  "bristol myers squibb": [
533
- "bms",
534
- "inst"
535
  ],
536
  "palobiofarma": [
537
  "inst"
538
  ],
539
  "dohme": [
540
- "msd",
541
- "inst"
542
  ],
543
  "mirati therapeutics": [
544
  "inst"
@@ -565,8 +565,8 @@
565
  "inst"
566
  ],
567
  "gsk": [
568
- "glaxosmithkline",
569
- "inst"
570
  ],
571
  "regeneron": [
572
  "inst"
@@ -624,26 +624,26 @@
624
  "health research methods"
625
  ],
626
  "health research methods": [
627
- "asco practice guidelines staff",
628
- "va asco practice guideline staff",
629
  "asco practice guideline staff",
630
- "va asco practice guidelines staff"
 
631
  ],
632
  "in tyrosine kinase inhibitor": [
633
  "tki"
634
  ],
635
  "tki": [
636
- "in tyrosine kinase inhibitor",
637
- "tyrosine kinase inhibitor"
638
  ],
639
  "reuss et al\n\n\n\nrate": [
640
  "orr"
641
  ],
642
  "orr": [
 
643
  "which had an overall response rate",
644
- "reuss et al\n\n\n\nrate",
645
  "- objective response rate",
646
- "rate"
647
  ],
648
  "disease control rate": [
649
  "dcr"
@@ -661,11 +661,11 @@
661
  "dor"
662
  ],
663
  "dor": [
 
 
664
  "the median\nduration of response",
665
  "with a median duration of response",
666
- "with a median duration of\nresponse",
667
- "the median duration of response",
668
- "- duration of response"
669
  ],
670
  "the most common treatment-emergent adverse events": [
671
  "teaes"
@@ -692,8 +692,8 @@
692
  "inst"
693
  ],
694
  "msd": [
695
- "dohme",
696
- "inst"
697
  ],
698
  "lilly": [
699
  "inst"
@@ -717,8 +717,8 @@
717
  "cancer care ontario"
718
  ],
719
  "cancer care ontario": [
720
- "asco-ontario health",
721
- "was published by asco and ontario health"
722
  ],
723
  "the median progression-free\nsurvival": [
724
  "pfs"
@@ -734,8 +734,8 @@
734
  ],
735
  "durvalumab": [
736
  "if ps improves\n\nv\n\nconsolidation immunotherapy",
737
- "if ps improves\n- consolidation immunotherapy",
738
- "consolidation immunotherapy"
739
  ],
740
  "if ps improves\n\nv\n\nconsolidation immunotherapy": [
741
  "durvalumab"
@@ -750,16 +750,16 @@
750
  "bite"
751
  ],
752
  "bite": [
753
- "a bispecific t-cell\nengager",
754
- "a bispecific t-cell engager"
755
  ],
756
  "the most\ncommon ae was cytokine release syndrome": [
757
  "crs"
758
  ],
759
  "crs": [
 
760
  "the most\ncommon ae was cytokine release syndrome",
761
- "cytokine release syndrome",
762
- "the most common ae was cytokine release syndrome"
763
  ],
764
  "asco-ontario health": [
765
  "cancer care ontario"
@@ -784,13 +784,13 @@
784
  ],
785
  "fda": [
786
  "or food and drug administration",
787
- "the food and drug administration",
788
- "entrectinib received food and\ndrug administration",
789
  "entrectinib received food and drug administration",
790
- "and the food and drug administration",
791
- "and the united states food and drug administration",
792
  "food and drug administration",
793
- "the us food and drug administration"
 
 
 
794
  ],
795
  "cytokine release syndrome": [
796
  "crs"
@@ -813,8 +813,8 @@
813
  ],
814
  "nets": [
815
  "tumors",
816
- "has grouped lung and thymic neuroendocrine\ntumours",
817
- "has grouped lung and thymic neuroendocrine tumours"
818
  ],
819
  "small cell lung cancer": [
820
  "nsclc",
@@ -824,15 +824,15 @@
824
  "lcnec"
825
  ],
826
  "lcnec": [
827
- "and\nlarge cell neuroendocrine carcinoma",
828
- "and large cell neuroendocrine carcinoma"
829
  ],
830
  "and thymic\ncarcinoid": [
831
  "thc"
832
  ],
833
  "thc": [
834
- "and thymic carcinoid",
835
- "and thymic\ncarcinoid"
836
  ],
837
  "org": [
838
  "esmo guidelines committee"
@@ -888,8 +888,8 @@
888
  "ssas"
889
  ],
890
  "ssas": [
891
- "-labelled somatostatin analogues",
892
  "medical options",
 
893
  "what is the role of somatostatin analogues"
894
  ],
895
  "urinary-free cortisol": [
@@ -935,19 +935,19 @@
935
  "cht"
936
  ],
937
  "cht": [
938
- "chemotherapy",
939
  "the addition of the chemotherapy",
940
- "platinum-based chemotherapy",
941
- "platinum-based chemo\ntherapy",
942
  "over platinum-based doublet\nchemotherapy",
943
- "over platinum-based doublet chemotherapy",
 
 
944
  "with or without prior adjuvant chemotherapy",
945
- "the beneficial effects of adjuvant chemotherapy",
946
- "mainly cytotoxic chemotherapy"
 
947
  ],
948
  "or systemic therapies": [
949
- "with options discussed in these guidelines",
950
- "with options\ndiscussed in these guidelines"
951
  ],
952
  "with options\ndiscussed in these guidelines": [
953
  "or systemic therapies"
@@ -956,8 +956,8 @@
956
  "functioning syndrome"
957
  ],
958
  "functioning syndrome": [
959
- "in case of\nclinical",
960
- "in case of clinical"
961
  ],
962
  "and the united states food and drug administration": [
963
  "fda"
@@ -973,9 +973,9 @@
973
  "rfa"
974
  ],
975
  "rfa": [
 
976
  "palliative surgery\nor radiofrequency ablation",
977
- "palliative surgery or radiofrequency ablation",
978
- "for these patients radiofrequency ablation"
979
  ],
980
  "or cryoablation or endobronchial treatment": [
981
  "ebt"
@@ -987,8 +987,8 @@
987
  "prrt"
988
  ],
989
  "prrt": [
990
- "peptide\nreceptor radionuclide therapy",
991
- "peptide receptor radionuclide therapy"
992
  ],
993
  "and interferon- a": [
994
  "ifna"
@@ -1040,8 +1040,8 @@
1040
  "-fluorouracil"
1041
  ],
1042
  "as alternative second-line": [
1043
- "in case of\nuncontrolled cs",
1044
- "in case of uncontrolled cs"
1045
  ],
1046
  "in case of\nuncontrolled cs": [
1047
  "as alternative second-line"
@@ -1074,8 +1074,8 @@
1074
  "thymic net recurrences may be local"
1075
  ],
1076
  "regional": [
1077
- "intrathoracic especially\npleural",
1078
- "intrathoracic especially pleural"
1079
  ],
1080
  "intrathoracic especially\npleural": [
1081
  "regional"
@@ -1085,12 +1085,12 @@
1085
  ],
1086
  "esmo-mcbs": [
1087
  "esmo-magnitude of clinical\nbenefit",
1088
- "esmo-magnitude of clinical benefit scale",
1089
- "an esmo magnitude of clinical benefit scale",
1090
- "esmo-magnitude of\nclinical benefit",
1091
  "an esmo\nmagnitude of clinical benefit scale",
1092
  "esmo-magnitude of clinical benefit",
1093
- "esmomagnitude of clinical benefit scale"
 
 
 
1094
  ],
1095
  "advanced carcinoids of the lung and thymus": [
1096
  "luna"
@@ -1144,15 +1144,15 @@
1144
  "chuv"
1145
  ],
1146
  "chuv": [
1147
- "centre hospitalier universitaire vaudois",
1148
- "centre hospitalier universitaire\nvaudois"
1149
  ],
1150
  "comparing low-dose computed tomography": [
1151
  "ldct"
1152
  ],
1153
  "ldct": [
1154
- "comparing low-dose computed tomography",
1155
- "low-dose ct"
1156
  ],
1157
  "such as lepidic adenocarcinomas": [
1158
  "previously named bronchioloalveolar carcinoma"
@@ -1177,11 +1177,11 @@
1177
  "who"
1178
  ],
1179
  "who": [
 
1180
  "world health organization",
1181
- "global statistics",
1182
  "global",
1183
- "the recent world health organization",
1184
- "vs universal"
1185
  ],
1186
  "with its further sub-classification of": [
1187
  "surgically resected"
@@ -1196,8 +1196,8 @@
1196
  "ais"
1197
  ],
1198
  "ais": [
1199
- "the categories adenocarcinoma in situ",
1200
  "proposed that ais be classified as tis",
 
1201
  "proposed\nthat ais be classified as tis"
1202
  ],
1203
  "minimally invasive adenocarcinoma": [
@@ -1229,18 +1229,18 @@
1229
  "uicc"
1230
  ],
1231
  "uicc": [
1232
- "the union for international cancer control",
1233
- "the union for\ninternational cancer control",
1234
  "union for international\ncancer control",
1235
- "union for international cancer control"
 
1236
  ],
1237
  "node and metastasis": [
1238
  "tnm"
1239
  ],
1240
  "tnm": [
1241
- "tumourenodeemetastasis",
1242
  "tumour-node-metastasis",
1243
- "node and metastasis"
1244
  ],
1245
  "proposed\nthat ais be classified as tis": [
1246
  "ais"
@@ -1268,9 +1268,9 @@
1268
  "accp"
1269
  ],
1270
  "accp": [
1271
- "the american college of chest physicians",
1272
  "whereas the american college of chest physicians",
1273
- "the\namerican college of chest physicians"
1274
  ],
1275
  "adjuvant chemotherapy": [
1276
  "radiotherapy"
@@ -1282,8 +1282,8 @@
1282
  "vats"
1283
  ],
1284
  "vats": [
1285
- "or a video-assisted thoracoscopic surgery",
1286
- "video-assisted thoracic surgery"
1287
  ],
1288
  "based on the lung cancer study group": [
1289
  "lcsg"
@@ -1347,10 +1347,10 @@
1347
  "neo"
1348
  ],
1349
  "neo": [
1350
- "resection and after",
1351
  "- immunotherapy is being studied in early nsclc as",
1352
  "immunotherapy is being studied in early nsclc as",
1353
- "the\nimmune strategy in the",
1354
  "the immune strategy in the"
1355
  ],
1356
  "cl\n\ntreatment of locally advanced stage": [
@@ -1385,8 +1385,8 @@
1385
  ],
1386
  "ests": [
1387
  "and the european\nsociety of thoracic surgeons",
1388
- "and european society of thoracic surgeons",
1389
- "and the european society of thoracic surgeons"
1390
  ],
1391
  "gv scagliotti": [
1392
  "eds"
@@ -1408,8 +1408,8 @@
1408
  "pulmonology"
1409
  ],
1410
  "pulmonology": [
1411
- "respiratory oncology unit",
1412
- "respiratory oncology"
1413
  ],
1414
  "edegem": [
1415
  "antwerp"
@@ -1430,11 +1430,11 @@
1430
  "stage iii"
1431
  ],
1432
  "stage iii": [
1433
- "and unresectable locally advanced",
 
1434
  "unresectable nsclc",
1435
  "treatment of locally advanced stage",
1436
- "- locally advanced nsclc",
1437
- "locally advanced nsclc"
1438
  ],
1439
  "in paral\npractice guidelines": [
1440
  "cpgs"
@@ -1446,9 +1446,9 @@
1446
  "see panel members listed in the appendix"
1447
  ],
1448
  "see panel members listed in the appendix": [
1449
- "experts were involved in this\nconsensus process",
1450
  "experts were involved in this consensus process",
1451
- "and a general consen\nconsensus process"
 
1452
  ],
1453
  "experts were involved in this\nconsensus process": [
1454
  "see panel members listed in the appendix"
@@ -1466,8 +1466,8 @@
1466
  "as relative value depends on personal"
1467
  ],
1468
  "respiratory literature": [
1469
- "especially on exercise\ntesting",
1470
- "especially on exercise testing"
1471
  ],
1472
  "especially on exercise\ntesting": [
1473
  "respiratory literature"
@@ -1581,13 +1581,13 @@
1581
  "pbc"
1582
  ],
1583
  "pbc": [
 
1584
  "five cycles of tremelimumab",
1585
- "five cycles of\n\ntremelimumab",
1586
- "platinum-based doublet chemotherapy"
1587
  ],
1588
  "carboplatin": [
1589
- "arm b",
1590
- "arm a"
1591
  ],
1592
  "arm a": [
1593
  "carboplatin"
@@ -1606,23 +1606,23 @@
1606
  "primary endpoint"
1607
  ],
1608
  "primary endpoint": [
1609
- "pbc\nsignificantly improved pfs",
1610
- "significantly improved os",
1611
  "pbc significantly improved pfs",
1612
  "level",
1613
- "-year os"
 
1614
  ],
1615
  "besides immune checkpoint\n\ninhibitor": [
1616
  "ici"
1617
  ],
1618
  "ici": [
1619
- "besides immune checkpoint inhibitor",
1620
  "besides immune checkpoint\n\ninhibitor",
1621
- "and have no prior immune checkpoint inhibitor"
 
1622
  ],
1623
  "esmo-magnitude of clinical benefit scale": [
1624
- "mcbs",
1625
- "esmo-mcbs"
1626
  ],
1627
  "mcbs": [
1628
  "esmo-magnitude of clinical benefit scale"
@@ -1652,8 +1652,8 @@
1652
  "ttfields"
1653
  ],
1654
  "ttfields": [
1655
- "tumour treating fields",
1656
- "tumour treating\nfields"
1657
  ],
1658
  "significantly improved os": [
1659
  "primary endpoint"
@@ -1662,14 +1662,14 @@
1662
  "esmo guidelines staff"
1663
  ],
1664
  "esmo guidelines staff": [
 
1665
  "ioanna ntai and claire bramley",
1666
  "jennifer lamarre and guy atchison",
1667
- "jennifer\nlamarre and guy atchison",
1668
  "valerie laforest"
1669
  ],
1670
  "valerie laforest": [
1671
- "esmo guidelines staff",
1672
- "esmo\nguidelines staff"
1673
  ],
1674
  "esmo\nguidelines staff": [
1675
  "valerie laforest"
@@ -1678,11 +1678,11 @@
1678
  "esmo scientific affairs staff"
1679
  ],
1680
  "esmo scientific affairs staff": [
1681
- "nicola latino and francesca chiovaro",
1682
- "nicola latino and\nfrancesca chiovaro",
1683
- "nicola latino",
1684
  "nicola\nlatino and francesca chiovaro",
1685
- "nicola\nlatino"
 
 
1686
  ],
1687
  "bristol\nmyers squibb": [
1688
  "bms"
@@ -1700,8 +1700,8 @@
1700
  "ipsos"
1701
  ],
1702
  "ipsos": [
1703
- "with a platinum-containing\nregimen",
1704
- "roche and regimen"
1705
  ],
1706
  "esmo clinical practice guideline": [
1707
  "cpg"
@@ -1719,9 +1719,9 @@
1719
  "ngs"
1720
  ],
1721
  "ngs": [
1722
- "multiplex platforms",
1723
  "by next-generation sequencing",
1724
- "such as next-generation sequencing"
 
1725
  ],
1726
  "egfr fish or immunohistochemistry": [
1727
  "ihc"
@@ -1733,17 +1733,17 @@
1733
  "ntrk"
1734
  ],
1735
  "ntrk": [
1736
- "- the neurotrophic receptor tyrosine kinase",
1737
- "or neurotrophic tyrosine receptor kinase",
1738
  "or neurotrophic tyrosine\nreceptor kinase",
1739
- "and the neurotrophic receptor tyrosine\nkinase"
 
1740
  ],
1741
  "detection is reliable by\nin situ hybridisation": [
1742
  "ish"
1743
  ],
1744
  "ish": [
1745
- "detection is reliable by in situ hybridisation",
1746
- "detection is reliable by\nin situ hybridisation"
1747
  ],
1748
  "mesenchymal-epithelial transition": [
1749
  "met"
@@ -1781,8 +1781,8 @@
1781
  "fdg"
1782
  ],
1783
  "fdg": [
1784
- "e\ndeoxy-d-glucose",
1785
- "-deoxy-d-glucose"
1786
  ],
1787
  "union for international\ncancer control": [
1788
  "uicc"
@@ -1811,10 +1811,10 @@
1811
  "mos"
1812
  ],
1813
  "mos": [
1814
- "and median os",
1815
  "malaysian oncological society",
1816
  "malaysia",
1817
- "the malaysian oncological society"
 
1818
  ],
1819
  "systemic progression\n\nlocal treatment": [
1820
  "surgery or ft"
@@ -1848,15 +1848,15 @@
1848
  "japan"
1849
  ],
1850
  "japan": [
1851
- "jsmo",
1852
- "j-alex"
1853
  ],
1854
  "and\nalesia": [
1855
  "asia"
1856
  ],
1857
  "asia": [
1858
- "and\nalesia",
1859
- "and alesia"
1860
  ],
1861
  "and continue targeted": [
1862
  "not mandatory for decision"
@@ -1889,8 +1889,8 @@
1889
  "mdor"
1890
  ],
1891
  "mdor": [
1892
- "the\nmedian duration of response",
1893
- "the median duration of response"
1894
  ],
1895
  "tropomyosin receptor tyrosine kinase": [
1896
  "trk"
@@ -1902,9 +1902,9 @@
1902
  "surgery or rt"
1903
  ],
1904
  "surgery or rt": [
 
1905
  "oligoprogression\n\nlocal treatment",
1906
  "local treatment",
1907
- "- local treatment",
1908
  "disease progression\n\nlocal treatment"
1909
  ],
1910
  "or combination therapy with a mek inhibitor": [
@@ -1932,8 +1932,8 @@
1932
  "kras"
1933
  ],
1934
  "kras": [
1935
- "the kirsten rat sarcoma virus",
1936
- "the\nkirsten rat sarcoma virus"
1937
  ],
1938
  "data regarding the role of local ablative therapy": [
1939
  "lat"
@@ -1972,8 +1972,8 @@
1972
  "esmo scientific affairs staff"
1973
  ],
1974
  "and dr svetlana jezdic": [
1975
- "esmo\nmedical affairs advisor",
1976
  "esmo medical affairs advisor",
 
1977
  "esmo medical affairs staff"
1978
  ],
1979
  "esmo\nmedical affairs advisor": [
@@ -1986,8 +1986,8 @@
1986
  "atorg"
1987
  ],
1988
  "atorg": [
1989
- "asian\nthoracic oncology research group",
1990
- "asian thoracic oncology research group"
1991
  ],
1992
  "chinese lung\ncancer research foundation limited": [
1993
  "clcrf"
@@ -2062,8 +2062,8 @@
2062
  "asmac"
2063
  ],
2064
  "asmac": [
2065
- "s\nde clinique",
2066
- "s de clinique"
2067
  ],
2068
  "rzte": [
2069
  "vsao"
@@ -2084,12 +2084,12 @@
2084
  "cancers"
2085
  ],
2086
  "relay": [
2087
- "advanced non-small-cell lung cancer",
2088
- "cancer"
2089
  ],
2090
  "non-small-cell lung cancer": [
2091
- "alesia",
2092
- "nsclc"
2093
  ],
2094
  "alesia": [
2095
  "non-small-cell lung cancer"
@@ -2111,9 +2111,9 @@
2111
  "chmp"
2112
  ],
2113
  "chmp": [
2114
- "tabrecta - summary of opinion",
2115
  "products for human use",
2116
- "retsevmo - summary of opinion"
 
2117
  ],
2118
  "tabrecta - summary of opinion": [
2119
  "chmp"
@@ -2150,8 +2150,8 @@
2150
  ],
2151
  "jsmo": [
2152
  "the\njapanese society of medical oncology",
2153
- "the japanese society of medical oncology",
2154
- "japan"
2155
  ],
2156
  "korea": [
2157
  "ksmo"
@@ -2166,10 +2166,10 @@
2166
  "psmo"
2167
  ],
2168
  "psmo": [
2169
- "the philippine society of medical oncology",
2170
  "and philippine society of medical oncology",
2171
- "the philippines",
2172
  "and philippine society of medical\noncology",
 
 
2173
  "the philippine society of\nmedical oncology"
2174
  ],
2175
  "singapore": [
@@ -2184,15 +2184,15 @@
2184
  "tos"
2185
  ],
2186
  "tos": [
2187
- "the taiwan oncology society",
2188
- "taiwan"
2189
  ],
2190
  "and thailand": [
2191
  "tsco"
2192
  ],
2193
  "tsco": [
2194
- "and thailand",
2195
  "and the\nthai society of clinical oncology",
 
2196
  "and the thai society of clinical oncology"
2197
  ],
2198
  "and the neurotrophic receptor tyrosine\nkinase": [
@@ -2229,8 +2229,8 @@
2229
  "tmk and hrk"
2230
  ],
2231
  "tmk and hrk": [
2232
- "only two of the six expert members from the ksmo",
2233
- "only two of the six\nexpert members from the ksmo"
2234
  ],
2235
  "performance status": [
2236
  "ecog ps"
@@ -2266,8 +2266,8 @@
2266
  "such as osimertinib"
2267
  ],
2268
  "such as osimertinib": [
2269
- "third-generation egfr tkis",
2270
- "generation tki"
2271
  ],
2272
  "generation tki": [
2273
  "such as osimertinib"
@@ -2306,9 +2306,9 @@
2306
  "traes"
2307
  ],
2308
  "traes": [
2309
- "treatment-related aes",
2310
  "what are the treatment-related adverse events",
2311
- "treatment-related adverse events"
2312
  ],
2313
  "and have no prior immune checkpoint inhibitor": [
2314
  "ici"
@@ -2326,8 +2326,8 @@
2326
  "jkn"
2327
  ],
2328
  "jkn": [
2329
- "ishmo\n\nthe jaminan kesehatan nasional",
2330
- "ishmo\n\n\nthe jaminan kesehatan nasional"
2331
  ],
2332
  "there is no regulation of partial coverage": [
2333
  "co-payment"
@@ -2339,8 +2339,8 @@
2339
  "pap"
2340
  ],
2341
  "pap": [
2342
- "program",
2343
- "esmo open\n\n\n\nprogram"
2344
  ],
2345
  "mandatory national health insurance": [
2346
  "nhi"
@@ -2368,8 +2368,8 @@
2368
  "alk inhibitors"
2369
  ],
2370
  "and atezolizumab": [
2371
- "in the second-line setting",
2372
- "in the\nsecond-line setting"
2373
  ],
2374
  "in the\nsecond-line setting": [
2375
  "and atezolizumab"
@@ -2385,8 +2385,8 @@
2385
  "first-line"
2386
  ],
2387
  "first-line": [
2388
- "and the alk inhibitors ceritinib and\nbrigatinib",
2389
- "and the alk inhibitors ceritinib and brigatinib"
2390
  ],
2391
  "german": [
2392
  "merck"
@@ -2395,8 +2395,8 @@
2395
  "torg"
2396
  ],
2397
  "torg": [
2398
- "thoracic oncology research group",
2399
- "thoracic oncology research\ngroup"
2400
  ],
2401
  "and west japan oncology group": [
2402
  "wjog"
@@ -2405,8 +2405,8 @@
2405
  "and west japan oncology group"
2406
  ],
2407
  "product samples": [
2408
- "non-renumerated",
2409
- "nonrenumerated"
2410
  ],
2411
  "nonrenumerated": [
2412
  "product samples"
@@ -2479,21 +2479,21 @@
2479
  "mnsclc"
2480
  ],
2481
  "mnsclc": [
2482
- "stage iv metastatic non-small-cell lung cancer",
2483
- "e-mutant metastatic nsclc"
2484
  ],
2485
  "binimetinib in patients": [
2486
  "pts"
2487
  ],
2488
  "pts": [
2489
- "versus docetaxel in patients",
2490
  "patients",
2491
- "therapy in patients",
2492
- "mo encorafenib plus\n\nbinimetinib in patients",
2493
- "p repotrectinib in patients",
2494
  "mo encorafenib plus binimetinib in patients",
2495
  "binimetinib in patients",
2496
- "osimertinib as adjuvant therapy in patients"
 
 
 
 
2497
  ],
2498
  "mutant advanced non-small cell lung cancer": [
2499
  "nsclc"
@@ -2509,8 +2509,8 @@
2509
  ],
2510
  "treatment of early stages": [
2511
  "stages i-ii",
2512
- "stages i and ii",
2513
- "stages i-iiia"
2514
  ],
2515
  "stages i-iiia": [
2516
  "treatment of early stages"
@@ -2523,8 +2523,8 @@
2523
  ],
2524
  "chemotherapy": [
2525
  "- everolimus\n - cht",
2526
- "adaura",
2527
- "cht"
2528
  ],
2529
  "the median\nwas not reached": [
2530
  "ne-ne"
@@ -2543,8 +2543,8 @@
2543
  "neo"
2544
  ],
2545
  "or docetaxel or pemetrexed": [
2546
- "only in\nadenocarcinoma tumours",
2547
- "only in adenocarcinoma tumours"
2548
  ],
2549
  "only in\nadenocarcinoma tumours": [
2550
  "or docetaxel or pemetrexed"
@@ -2553,9 +2553,9 @@
2553
  "port"
2554
  ],
2555
  "port": [
2556
- "comparing post-operative conformal radiotherapy",
2557
  "post-operative radiotherapy",
2558
- "postoperative radiotherapy"
2559
  ],
2560
  "treatment of locally advanced stage": [
2561
  "stage iii"
@@ -2594,9 +2594,9 @@
2594
  "pacific"
2595
  ],
2596
  "pacific": [
2597
- "small-cell lung cancer",
2598
  "concurrent chemoradiation therapy",
2599
- "unresectable non-small-cell lung cancer"
 
2600
  ],
2601
  "adaura": [
2602
  "chemotherapy"
@@ -2605,8 +2605,8 @@
2605
  "including stage ib"
2606
  ],
2607
  "including stage ib": [
2608
- "approval was based on all patient data",
2609
- "d approval was based on all patient data"
2610
  ],
2611
  "on tumour cells": [
2612
  "as per the\nema-approved indication",
@@ -2649,8 +2649,8 @@
2649
  "egfrm"
2650
  ],
2651
  "nivolumab": [
2652
- "bristol myers squibb statement on opdivo",
2653
- "nivo"
2654
  ],
2655
  "nivo": [
2656
  "nivolumab"
@@ -2659,16 +2659,16 @@
2659
  "chemo"
2660
  ],
2661
  "chemo": [
 
2662
  "platinum-doublet chemotherapy",
2663
- "platinum-doublet\nchemotherapy",
2664
- "platinum-based chemotherapy"
2665
  ],
2666
  "for\nresectable": [
2667
  "ib-iiia"
2668
  ],
2669
  "ib-iiia": [
2670
- "for\nresectable",
2671
- "for resectable"
2672
  ],
2673
  "lung cancer": [
2674
  "nsclc"
@@ -2692,8 +2692,8 @@
2692
  "diques august pi i sunyer"
2693
  ],
2694
  "department of radiation oncology": [
2695
- "maastro",
2696
- "maastro clinic"
2697
  ],
2698
  "maastro clinic": [
2699
  "department of radiation oncology"
@@ -3215,8 +3215,8 @@
3215
  "rfa"
3216
  ],
3217
  "peptide receptor radionuclide therapy": [
3218
- "prrt",
3219
- "- prrt"
3220
  ],
3221
  "what is the role of somatostatin analogues": [
3222
  "ssas"
@@ -3423,8 +3423,8 @@
3423
  "fda"
3424
  ],
3425
  "the median duration of response": [
3426
- "dor",
3427
- "mdor"
3428
  ],
3429
  "deruxtecan": [
3430
  "fda approved"
@@ -3535,13 +3535,13 @@
3535
  "author"
3536
  ],
3537
  "author": [
 
 
3538
  "jchy",
 
3539
  "msi",
3540
  "tmk",
3541
- "ddwl",
3542
- "cew",
3543
- "sak",
3544
- "hrk"
3545
  ],
3546
  "hrk": [
3547
  "author"
@@ -3661,158 +3661,158 @@
3661
  },
3662
  "abbreviations": {
3663
  "esmo": [
 
 
 
3664
  "european\nsociety of medical oncology",
3665
  "the following european society for medical oncology",
3666
- "european society of medical oncology",
3667
- "european society for medical oncology",
3668
  "living guideline\n\nthe following european society for medical oncology",
3669
- "european society for medical\noncology",
3670
  "european society for\nmedical oncology",
3671
- "the european society for medical oncology",
3672
- "the most recent european society for medical oncology"
3673
  ],
3674
  "asco": [
3675
- "american society of clinical\noncology",
3676
  "american society of clinical\n\noncology",
3677
- "american society of clinical oncology",
3678
- "american\nsociety of clinical oncology",
3679
- "this american society of clinical oncology",
3680
  "journal of clinical oncology",
3681
- "the clinical practice guidelines published herein are provided by the american society of clinical oncology inc"
 
 
 
 
3682
  ],
3683
  "aiom": [
3684
- "italian association\nof medical oncology",
3685
  "italian association of medical oncology",
3686
- "the italian association of medical oncology"
3687
  ],
3688
  "nccn": [
3689
- "american cancer centers",
3690
- "national comprehensive cancer network"
3691
  ],
3692
  "glides": [
 
3693
  "guidelines into decision\nsupport",
3694
- "guidelines into decision support",
3695
- "ecision support"
3696
  ],
3697
  "glc": [
3698
  "guidelines committee"
3699
  ],
3700
  "mcbs": [
3701
- "magnitude of clinical benefit score",
3702
  "magnitude\nof clinical benefit score",
3703
- "magnitude of clinical benefit scale"
3704
  ],
3705
  "ema": [
3706
  "european medicines\nagency",
3707
  "european medicines agency"
3708
  ],
3709
  "sclc": [
3710
- "clinical practice guidelines on small cell lung cancer",
3711
- "small cell lung cancer",
3712
  "what is the treatment algorithm for patients with small cell lung cancer",
 
3713
  "clinical practice guidelines on small cell lung\ncancer",
 
3714
  "what are the recommended treatment options for patients with relapsed small cell lung cancer"
3715
  ],
3716
  "cco": [
3717
  "cancer care ontario"
3718
  ],
3719
  "astro": [
3720
- "executive summary of an american society for radiation oncology",
3721
- "executive summary of an american society for\nradiation oncology"
3722
  ],
3723
  "inst": [
3724
- "merck",
3725
- "trizell",
3726
- "regeneron",
3727
- "lilly",
3728
- "heart therapeutics",
3729
- "elevation oncology",
3730
- "amgen",
3731
- "janssen oncology",
3732
- "verastem",
3733
- "myers squibb",
3734
- "black diamond therapeutics",
3735
- "zeneca",
3736
- "janssen",
3737
- "guardant health",
3738
- "palobiofarma",
3739
- "constellation pharmaceuticals",
3740
- "immune",
3741
  "blueprint medicines",
3742
- "nuvation bio",
3743
- "pfizer",
3744
- "therapeutics",
3745
- "mirati therapeutics",
3746
  "revolution medicines",
 
 
 
 
 
 
 
 
 
 
 
 
 
 
3747
  "dohme",
3748
- "summit therapeutics",
3749
  "harpoon therapeutics",
3750
- "macrogenics",
 
3751
  "kline canada",
3752
- "jazz pharmaceuticals",
3753
- "kline",
3754
- "genentech",
 
 
 
 
 
 
 
 
3755
  "takeda",
3756
- "astra zeneca",
3757
- "genomics",
3758
- "cullinan oncology",
3759
- "zeneca canada",
3760
- "bristol myers\nsquibb",
3761
  "dizal\npharma",
 
 
 
 
3762
  "puma biotechnology",
3763
- "advaxis",
3764
- "novartis",
3765
  "vivace therapeutics",
3766
- "turning point therapeutics",
3767
- "astex pharmaceuticals",
3768
- "merck serono",
3769
- "exelixis",
3770
  "bayer",
3771
- "dizal pharma",
3772
- "inhibrx",
3773
- "calithera biosciences",
3774
- "polaris",
3775
- "arcus biosciences",
3776
- "black diamond\ntherapeutics",
3777
- "boehringer ingelheim",
3778
- "sutro biopharma",
3779
- "bristol myers squibb",
3780
- "forward",
3781
- "roche",
3782
  "pharmaceuticals",
3783
- "bristol myers squibb foundation"
 
 
 
 
 
 
 
 
3784
  ],
3785
  "ct": [
3786
- "the use of computed tomography",
3787
- "computed tomography",
3788
  "the use of\ncomputed tomography",
3789
- "clinicians should use a diagnostic chest computed tomography"
 
 
3790
  ],
3791
  "mri": [
3792
  "what is the role of brain magnetic resonance imaging"
3793
  ],
3794
  "sbrt": [
3795
- "salvage stereotactic body radiation therapy",
3796
- "stereotactic body radiotherapy"
3797
  ],
3798
  "cap": [
3799
  "pathologists",
3800
  "college of american pathologists"
3801
  ],
3802
  "iaslc": [
 
 
 
 
3803
  "pathology committee chair for international association for the study of lung cancer",
3804
  "study of lung cancer",
3805
- "the\ninternational association for the study of lung cancer",
3806
  "pathology committee chair\nfor international association for the study of lung cancer",
3807
- "international association for the\nstudy of lung cancer",
3808
  "international association for the study of lung cancer",
3809
- "international association for the\n\nstudy of lung cancer",
3810
- "the international association for the study of lung cancer",
3811
- "international association for\nthe study of lung cancer"
3812
  ],
3813
  "amp": [
3814
- "association\nfor molecular pathology",
3815
- "association for molecular pathology"
3816
  ],
3817
  "ihc": [
3818
  "immunohistochemistry"
@@ -3824,11 +3824,11 @@
3824
  "although the results from the mesothelioma and radical surgery"
3825
  ],
3826
  "os": [
3827
- "the median\noverall survival",
3828
- "median overall survival",
3829
  "overall survival",
3830
  "the median overall survival",
3831
- "the only data published thus far pertain to the dual primary end points of overall survival"
 
 
3832
  ],
3833
  "elsevier": [
3834
  "clinical lung cancer"
@@ -3837,27 +3837,27 @@
3837
  "one randomized controlled trial"
3838
  ],
3839
  "ps": [
3840
- "eastern cooperative oncology group performance\nstatus",
3841
- "eastern cooperative oncology group performance status"
3842
  ],
3843
  "orr": [
3844
  "is result in a lower overall response\nrate",
3845
- "objective response rate",
3846
  "is result in a lower overall response rate",
 
3847
  "reuss et al\n\n\n\nrate"
3848
  ],
3849
  "pci": [
3850
- "prophylactic cranial irradiation",
3851
- "what is the role of prophylactic cranial irradiation"
3852
  ],
3853
  "fda": [
3854
- "entrectinib received food and\ndrug administration",
3855
  "entrectinib received food and drug administration",
3856
- "osimertinib is approved by both the united states food and drug administration",
3857
- "food and drug administration",
3858
  "osimertinib is approved by both the united states food and\ndrug administration",
3859
- "united states food and drug administration",
3860
- "these results led to the food\n\nand drug administration"
 
 
3861
  ],
3862
  "crs": [
3863
  "cytokine release syndrome"
@@ -3866,44 +3866,44 @@
3866
  "department of surgical sciences"
3867
  ],
3868
  "who": [
3869
- "the latest world health organization",
3870
  "world health organization",
3871
- "global statistics",
3872
  "global",
3873
- "the recent world health organization"
 
3874
  ],
3875
  "lc": [
3876
- "these guidelines are restricted to lung carcinoid",
3877
- "these\nguidelines are restricted to lung carcinoid"
3878
  ],
3879
  "seer": [
3880
- "epidemiology and end results",
3881
- "end results"
3882
  ],
3883
  "uicc": [
 
3884
  "edition of the union for\ninternational cancer control",
 
3885
  "union for international cancer control",
3886
- "union for international\ncancer control",
3887
- "edition of the union for international cancer control",
3888
- "union for\ninternational cancer control"
3889
  ],
3890
  "gep": [
3891
- "based on\napproval and recommendations in gastroenteropancreatic",
3892
- "based on approval and recommendations in gastroenteropancreatic"
3893
  ],
3894
  "pth": [
3895
  "annals of oncology\n\n\n\nparathyroid hormone"
3896
  ],
3897
  "rfa": [
 
3898
  "palliative surgery\nor radiofrequency ablation",
3899
- "palliative surgery or radiofrequency ablation",
3900
- "for these patients radiofrequency ablation"
3901
  ],
3902
  "recist": [
3903
  "cs with response evaluation criteria in solid tumours",
3904
- "measurements and response assessment should follow\nresponse evaluation criteria in solid tumours",
3905
  "measurements and response assessment should follow response evaluation criteria in solid tumours",
3906
- "cs with response evaluation criteria\nin solid tumours"
3907
  ],
3908
  "gemox": [
3909
  "oxaliplatin combined with gemcitabine"
@@ -3912,8 +3912,8 @@
3912
  "lanreotide autogel"
3913
  ],
3914
  "chuv": [
3915
- "centre hospitalier universitaire vaudois",
3916
- "centre hospitalier universitaire\nvaudois"
3917
  ],
3918
  "nlst": [
3919
  "the much larger national lung cancer screening trial",
@@ -3964,12 +3964,12 @@
3964
  "the thoracic surgery scoring\nsystem"
3965
  ],
3966
  "pulmonology": [
3967
- "respiratory oncology unit",
3968
- "respiratory oncology"
3969
  ],
3970
  "acs": [
3971
- "lung cancer screening guidelines published by the american cancer society",
3972
- "lung cancer screening guidelines published by the\namerican cancer society"
3973
  ],
3974
  "ialt": [
3975
  "some trials"
@@ -3978,11 +3978,11 @@
3978
  "adjuvant navelbine international trialist association"
3979
  ],
3980
  "sabr": [
 
3981
  "what are the indications and recommendations for salvage surgery after stereotactic ablative radiotherapy",
3982
- "radiographic changes after lung stereotactic ablative radiotherapy",
3983
  "what are the outcomes comparing stereotactic ablative radiotherapy",
3984
- "radiographic changes after lung stereotactic\nablative radiotherapy",
3985
- "consolidative stereotactic ablative radiotherapy"
3986
  ],
3987
  "vumc": [
3988
  "vrije\nuniversity medical centre",
@@ -3993,36 +3993,36 @@
3993
  "bemeneed"
3994
  ],
3995
  "bms": [
 
3996
  "myers\nsquibb",
 
3997
  "bristol myers\nsquibb",
3998
- "bristol\nmyers squibb",
3999
- "bristol myers squibb",
4000
- "myers squibb"
4001
  ],
4002
  "msd": [
4003
  "dohme"
4004
  ],
4005
  "eortc": [
4006
- "chair of the european organisation for research and treatment of cancer",
4007
  "chair of the european\norganisation for research and treatment of cancer",
4008
- "european organisation for research and treatment of cancer",
4009
  "treatment of cancer",
4010
- "european\norganisation for research and treatment of cancer"
 
4011
  ],
4012
  "cpg": [
4013
  "clinical practice guideline"
4014
  ],
4015
  "escat": [
4016
  "scale for clinical actionability of\nmolecular targets",
4017
- "scale for clinical actionability of molecular targets",
4018
- "targets"
4019
  ],
4020
  "alk": [
4021
  "positive anaplastic lymphoma kinase"
4022
  ],
4023
  "ish": [
4024
- "detection is reliable by in situ hybridisation",
4025
- "detection is reliable by\nin situ hybridisation"
4026
  ],
4027
  "cns": [
4028
  "imaging of the central nervous system"
@@ -4041,8 +4041,8 @@
4041
  "interstitial lung disease"
4042
  ],
4043
  "kras": [
4044
- "the kirsten rat sarcoma virus",
4045
- "the\nkirsten rat sarcoma virus"
4046
  ],
4047
  "lat": [
4048
  "data regarding the role of local ablative therapy"
@@ -4058,17 +4058,17 @@
4058
  "lung cancer group and past secretary and current\nchair of the nederlandse vereniging van artsen voor longziekten en tuberculose"
4059
  ],
4060
  "atorg": [
4061
- "asian\nthoracic oncology research group",
4062
- "asian thoracic oncology research group"
4063
  ],
4064
  "clcrf": [
4065
  "chinese lung\ncancer research foundation limited",
4066
  "chinese lung cancer research foundation limited"
4067
  ],
4068
  "csco": [
4069
- "chinese\nsociety of clinical oncology",
4070
  "chinese society of clinical oncology",
4071
- "china"
 
4072
  ],
4073
  "hkcf": [
4074
  "hong kong cancer fund"
@@ -4087,13 +4087,13 @@
4087
  "research to practice"
4088
  ],
4089
  "samo": [
4090
- "president of swiss\nacademy of multidisciplinary oncology",
4091
- "president of swiss academy of multidisciplinary oncology"
4092
  ],
4093
  "sakk": [
4094
  "research",
4095
- "president of lung group for swiss group for clinical cancer\nresearch",
4096
- "president of lung group for swiss group for clinical cancer research"
4097
  ],
4098
  "etop": [
4099
  "european thoracic oncology platform"
@@ -4102,8 +4102,8 @@
4102
  "international breast cancer study group"
4103
  ],
4104
  "aacr": [
4105
- "partners member of american association of cancer research",
4106
- "partners member\nof american association of cancer research"
4107
  ],
4108
  "asmac": [
4109
  "clinique"
@@ -4113,20 +4113,20 @@
4113
  ],
4114
  "chmp": [
4115
  "summary of opinion",
4116
- "committee for medicinal products for human use",
4117
- "products for human use"
4118
  ],
4119
  "paga": [
4120
  "asian adapted"
4121
  ],
4122
  "ishmo": [
4123
- "indonesia",
4124
  "indonesian society\nof hematology and medical oncology",
4125
- "indonesian society of hematology and medical oncology"
 
4126
  ],
4127
  "jsmo": [
4128
- "japanese society of medical oncology",
4129
- "japan"
4130
  ],
4131
  "ksmo": [
4132
  "korea",
@@ -4137,9 +4137,9 @@
4137
  "malaysia"
4138
  ],
4139
  "psmo": [
4140
- "philippine society of\nmedical oncology",
4141
- "philippine society of medical\noncology",
4142
  "philippines",
 
 
4143
  "philippine society of medical oncology"
4144
  ],
4145
  "sso": [
@@ -4148,8 +4148,8 @@
4148
  "singapore"
4149
  ],
4150
  "tos": [
4151
- "taiwan oncology society",
4152
- "taiwan"
4153
  ],
4154
  "tsco": [
4155
  "thai society of clinical oncology",
@@ -4163,31 +4163,31 @@
4163
  "national medical products\nadministration"
4164
  ],
4165
  "nmpa": [
4166
- "chinese national medical products administration",
4167
- "chinese national\nmedical products administration"
4168
  ],
4169
  "jkn": [
4170
  "the jaminan kesehatan nasional"
4171
  ],
4172
  "fornas": [
4173
- "na\ntional drug formulary",
4174
  "national standard of medication list",
4175
  "national standard of\nmedication list",
4176
- "national drug formulary"
 
4177
  ],
4178
  "pap": [
4179
  "open\n\n\n\nprogram"
4180
  ],
4181
  "pdma": [
4182
- "it may take\nfrom several months to years for the pharmaceuticals and\nmedical devices agency",
4183
- "it may take from several months to years for the pharmaceuticals and medical devices agency"
4184
  ],
4185
  "nhi": [
4186
  "national health insurance"
4187
  ],
4188
  "torg": [
4189
- "thoracic oncology research group",
4190
- "thoracic oncology research\ngroup"
4191
  ],
4192
  "wjog": [
4193
  "west japan oncology group"
@@ -4196,8 +4196,8 @@
4196
  "trial steering committee"
4197
  ],
4198
  "idmc": [
4199
- "committee",
4200
- "independent data monitoring committee"
4201
  ],
4202
  "ukiog": [
4203
  "ireland oesophagogastric group"
@@ -4295,10 +4295,10 @@
4295
  "diffuse idiopathic pulmonary neuroendocrine cell hyperplasia"
4296
  ],
4297
  "port": [
4298
- "postoperative radiotherapy",
4299
- "radiotherapy",
4300
  "what is the current evidence and recommendation for postoperative radiotherapy",
4301
- "what are the outcomes and recommendations for postoperative radiotherapy"
 
 
4302
  ],
4303
  "i-v": [
4304
  "classification system showing five levels of evidence"
 
4
  "esmo"
5
  ],
6
  "esmo": [
7
+ "european society for medical oncology",
8
  "the european society for medical\noncology",
9
+ "european\nsociety of medical oncology",
10
  "european society of medical oncology",
 
11
  "european society for\nmedical oncology",
12
+ "the european society for medical oncology"
 
13
  ],
14
  "american society of clinical\n\noncology": [
15
  "asco"
16
  ],
17
  "asco": [
18
  "american society of clinical\n\noncology",
 
 
19
  "s note\n\nthis american society of clinical oncology",
 
20
  "journal of clinical oncology",
21
+ "inc",
22
+ "american\nsociety of clinical oncology",
23
+ "md american society of clinical oncology",
24
+ "american society of clinical oncology"
25
  ],
26
  "italian association of medical oncology": [
27
  "aiom"
28
  ],
29
  "aiom": [
30
+ "italian association of medical oncology",
31
+ "italian association\nof medical oncology"
32
  ],
33
  "national comprehensive cancer network": [
34
  "nccn"
35
  ],
36
  "nccn": [
37
  "national comprehensive cancer network",
38
+ "vs insurance-based",
39
+ "leading american cancer centers"
40
  ],
41
  "non-small cell lung cancer": [
42
  "nsclc"
43
  ],
44
  "nsclc": [
 
 
 
45
  "non-small-cell lung cancer",
46
+ "iii non-small-cell lung cancer",
47
  "small cell lung cancer",
 
 
48
  "small-cell\nlung cancer",
49
+ "advanced non-small cell lung cancer",
 
 
50
  "lung cancer",
51
  "non-small cell lung cancer",
52
+ "small-cell lung cancer",
53
  "cancer",
54
+ "e-mutant advanced non-small cell lung cancer",
55
  "small cell\nlung cancer",
56
+ "advanced non-small-cell lung cancer",
57
+ "-rearranged advanced non-small-cell lung cancer",
58
+ "robotic lobectomy for non-small cell lung cancer",
59
+ "mutant advanced non-small cell lung cancer",
60
+ "stage iii non small cell lung cancer"
61
  ],
62
  "american\nsociety of clinical oncology": [
63
  "asco"
 
76
  ],
77
  "glides": [
78
  "guidelines into decision support",
79
+ "using the guidelines into decision\nsupport",
80
+ "using the guidelines into decision support"
81
  ],
82
  "for all the newly\neuropean medicines agency": [
83
  "ema"
84
  ],
85
  "ema": [
 
 
 
86
  "for all the newly\neuropean medicines agency",
87
+ "and the european medicines\nagency",
88
+ "european medicines agency",
89
  "not european medicines agency",
90
+ "for all the newly european medicines agency",
91
+ "and the european medicines agency"
92
  ],
93
  "evaluates treatments with curative intent": [
94
  "such\nas adjuvant chemotherapy",
 
131
  "bsc"
132
  ],
133
  "bsc": [
 
 
134
  "or best supportive care",
135
+ "or best supportive\ncare",
136
+ "leads to increased dfs versus best supportive care",
137
+ "leads to\nincreased dfs versus best supportive care"
138
  ],
139
  "author affiliations\nand support\n\ninformation": [
140
  "if\n\napplicable"
 
152
  "rcts"
153
  ],
154
  "rcts": [
155
+ "controlled trials",
156
  "clinical trials",
157
+ "two randomized control trials"
 
158
  ],
159
  "the primary end point was disease-free\nsurvival": [
160
  "dfs"
161
  ],
162
  "dfs": [
 
163
  "disease-free survival",
164
+ "the primary end point was disease-free\nsurvival",
165
+ "the primary end point was disease-free survival"
166
  ],
167
  "joint cancer care ontario": [
168
  "cco"
 
177
  "inst"
178
  ],
179
  "inst": [
180
+ "advaxis",
181
+ "bristol myers squibb",
182
+ "blueprint medicines",
183
+ "dizal pharma",
184
  "crispr\ntherapeutics",
185
+ "astex pharmaceuticals",
186
+ "revolution medicines",
 
 
 
 
 
 
 
 
 
 
 
 
187
  "black diamond therapeutics",
188
+ "verastem",
189
  "msd",
190
+ "sutro biopharma",
191
+ "novartis",
192
+ "bristol myers\nsquibb",
193
+ "merck",
194
+ "oncomed",
195
+ "gsk",
196
+ "black diamond\ntherapeutics",
197
+ "therapeutics",
198
  "guardant health",
199
+ "crispr therapeutics",
200
+ "jazz pharmaceuticals",
201
+ "amgen",
202
+ "calithera biosciences",
203
+ "oric pharmaceuticals",
204
+ "inc",
205
+ "dohme",
206
+ "bristol-myers squibb",
207
+ "astra zeneca",
208
+ "harpoon therapeutics",
209
  "pfizer",
210
+ "bms",
211
+ "nuvation bio",
212
+ "turning point therapeutics",
213
  "pharmamar",
214
+ "trizell",
215
+ "roche",
216
+ "arcus biosciences",
 
 
217
  "summit therapeutics",
218
+ "astrazeneca",
219
+ "astrazeneca canada",
220
+ "lilly",
221
+ "forward",
222
+ "neogenomics",
223
  "takeda",
224
+ "medimmune",
 
225
  "abbvie",
 
226
  "dizal\npharma",
227
+ "janssen oncology",
228
+ "glaxosmithkline canada",
229
+ "polaris",
230
+ "mirati therapeutics",
231
  "puma biotechnology",
232
+ "cullinan oncology",
233
+ "glaxosmithkline",
234
+ "constellation pharmaceuticals",
235
  "vivace therapeutics",
236
+ "palobiofarma",
237
+ "bristol myers squibb foundation",
 
 
 
 
238
  "bayer",
 
 
 
 
 
 
 
239
  "boehringer ingelheim",
240
+ "regeneron",
241
+ "inhibrx",
242
+ "exelixis",
243
+ "merck serono",
244
+ "janssen",
245
+ "macrogenics",
246
+ "elevation oncology",
247
+ "genentech",
248
+ "anheart therapeutics"
249
  ],
250
  "pfizer": [
251
  "inst"
 
254
  "inst"
255
  ],
256
  "bristol-myers squibb": [
257
+ "inst",
258
+ "bms"
259
  ],
260
  "medimmune": [
261
  "inst"
 
304
  "continued"
305
  ],
306
  "continued": [
307
+ "all recommendations",
308
  "the bottom line",
309
+ "medical guideline document - esmo open references"
310
  ],
311
  "salvage stereotactic body radiation therapy": [
312
  "sbrt"
313
  ],
314
  "sbrt": [
315
+ "stereotactic body radiotherapy",
316
  "salvage stereotactic body radiation therapy",
 
317
  "sabr or stereotactic body radiotherapy",
318
+ "fdg-pet and stereotactic body radiotherapy"
319
  ],
320
  "oncomed": [
321
  "inst"
 
330
  "cap"
331
  ],
332
  "cap": [
333
+ "thecollege of americanpathologists",
334
+ "the college of american pathologists"
335
  ],
336
  "association\nfor molecular pathology": [
337
  "amp"
338
  ],
339
  "amp": [
340
+ "association for molecular pathology",
341
+ "association\nfor molecular pathology"
342
  ],
343
  "and anaplastic lymphoma kinase": [
344
  "alk"
345
  ],
346
  "alk": [
 
 
347
  "crizotinib-pretreated anaplastic lymphoma kinase",
348
+ "positive anaplastic lymphoma kinase",
349
+ "and anaplastic lymphoma kinase",
350
+ "phoma kinase"
351
  ],
352
  "immunohistochemistry": [
353
  "ihc"
354
  ],
355
  "ihc": [
356
+ "immunohistochemistry",
357
+ "egfr fish or immunohistochemistry"
358
  ],
359
  "merck": [
360
+ "inst",
361
+ "german"
362
  ],
363
  "glaxosmithkline": [
364
  "gsk",
 
371
  "inst"
372
  ],
373
  "bristol myers\nsquibb": [
374
+ "inst",
375
+ "bms"
376
  ],
377
  "polaris": [
378
  "inst"
 
411
  "icis"
412
  ],
413
  "icis": [
414
+ "neoadjuvant immune checkpoint inhibitors",
415
+ "immune checkpoint inhibitors"
416
  ],
417
  "american society of clinical oncology": [
418
  "asco"
 
433
  "inst"
434
  ],
435
  "bms": [
436
+ "bristol myers squibb",
437
  "inst",
438
+ "bristol-myers squibb",
439
  "bristol myers\nsquibb",
440
+ "bristol-myers\nsquibb",
441
  "celgene",
442
+ "bristol\nmyers squibb"
 
 
443
  ],
444
  "trizell": [
445
  "inst"
 
457
  "rct"
458
  ],
459
  "rct": [
460
+ "phase iib\nrandomised controlled trial",
461
  "phase iib randomised controlled trial",
 
462
  "a phase iii randomised clinical trial",
463
+ "phase iii randomised clinical trial",
464
+ "one randomized controlled trial"
465
  ],
466
  "the primary end point of progression-free survival": [
467
  "pfs"
468
  ],
469
  "pfs": [
 
 
 
 
470
  "and progression-free survival",
471
+ "the median progression-free survival",
472
  "quality of life and progression-free survival",
473
+ "reported improved progression-free survival",
 
474
  "reported improved\nprogression-free survival",
475
+ "the primary end point of progression-free survival",
476
+ "the median\nprogression-free survival",
477
+ "progression-free survival",
478
+ "the median progression-free\nsurvival",
479
+ "no\nimprovement in progression-free survival",
480
+ "and\nprogression-free survival"
481
  ],
482
  "adverse events": [
483
  "aes",
 
485
  ],
486
  "aes": [
487
  "mainly altered lipid levels",
488
+ "adverse\nevents",
489
+ "adverse events"
490
  ],
491
  "and consolidation": [
492
  "for unresectable stage iii nsclc"
 
498
  "osimertinib"
499
  ],
500
  "osimertinib": [
501
+ "treatment is now an egfr-targeted drug",
502
  "osi",
503
+ "treatment is now an\negfr-targeted drug"
504
  ],
505
  "inc": [
506
+ "inst",
507
+ "asco"
508
  ],
509
  "small cell\nlung cancer": [
510
  "nsclc"
 
519
  "vegf"
520
  ],
521
  "vegf": [
522
+ "and vascular\nendothelial growth factor",
523
+ "and vascular endothelial growth factor"
524
  ],
525
  "though rates of\nimmune-related aes": [
526
  "iraes"
 
530
  "though rates of immune-related aes"
531
  ],
532
  "bristol myers squibb": [
533
+ "inst",
534
+ "bms"
535
  ],
536
  "palobiofarma": [
537
  "inst"
538
  ],
539
  "dohme": [
540
+ "inst",
541
+ "msd"
542
  ],
543
  "mirati therapeutics": [
544
  "inst"
 
565
  "inst"
566
  ],
567
  "gsk": [
568
+ "inst",
569
+ "glaxosmithkline"
570
  ],
571
  "regeneron": [
572
  "inst"
 
624
  "health research methods"
625
  ],
626
  "health research methods": [
627
+ "va asco practice guidelines staff",
 
628
  "asco practice guideline staff",
629
+ "asco practice guidelines staff",
630
+ "va asco practice guideline staff"
631
  ],
632
  "in tyrosine kinase inhibitor": [
633
  "tki"
634
  ],
635
  "tki": [
636
+ "tyrosine kinase inhibitor",
637
+ "in tyrosine kinase inhibitor"
638
  ],
639
  "reuss et al\n\n\n\nrate": [
640
  "orr"
641
  ],
642
  "orr": [
643
+ "rate",
644
  "which had an overall response rate",
 
645
  "- objective response rate",
646
+ "reuss et al\n\n\n\nrate"
647
  ],
648
  "disease control rate": [
649
  "dcr"
 
661
  "dor"
662
  ],
663
  "dor": [
664
+ "- duration of response",
665
+ "the median duration of response",
666
  "the median\nduration of response",
667
  "with a median duration of response",
668
+ "with a median duration of\nresponse"
 
 
669
  ],
670
  "the most common treatment-emergent adverse events": [
671
  "teaes"
 
692
  "inst"
693
  ],
694
  "msd": [
695
+ "inst",
696
+ "dohme"
697
  ],
698
  "lilly": [
699
  "inst"
 
717
  "cancer care ontario"
718
  ],
719
  "cancer care ontario": [
720
+ "was published by asco and ontario health",
721
+ "asco-ontario health"
722
  ],
723
  "the median progression-free\nsurvival": [
724
  "pfs"
 
734
  ],
735
  "durvalumab": [
736
  "if ps improves\n\nv\n\nconsolidation immunotherapy",
737
+ "consolidation immunotherapy",
738
+ "if ps improves\n- consolidation immunotherapy"
739
  ],
740
  "if ps improves\n\nv\n\nconsolidation immunotherapy": [
741
  "durvalumab"
 
750
  "bite"
751
  ],
752
  "bite": [
753
+ "a bispecific t-cell engager",
754
+ "a bispecific t-cell\nengager"
755
  ],
756
  "the most\ncommon ae was cytokine release syndrome": [
757
  "crs"
758
  ],
759
  "crs": [
760
+ "the most common ae was cytokine release syndrome",
761
  "the most\ncommon ae was cytokine release syndrome",
762
+ "cytokine release syndrome"
 
763
  ],
764
  "asco-ontario health": [
765
  "cancer care ontario"
 
784
  ],
785
  "fda": [
786
  "or food and drug administration",
 
 
787
  "entrectinib received food and drug administration",
788
+ "entrectinib received food and\ndrug administration",
 
789
  "food and drug administration",
790
+ "the food and drug administration",
791
+ "and the united states food and drug administration",
792
+ "the us food and drug administration",
793
+ "and the food and drug administration"
794
  ],
795
  "cytokine release syndrome": [
796
  "crs"
 
813
  ],
814
  "nets": [
815
  "tumors",
816
+ "has grouped lung and thymic neuroendocrine tumours",
817
+ "has grouped lung and thymic neuroendocrine\ntumours"
818
  ],
819
  "small cell lung cancer": [
820
  "nsclc",
 
824
  "lcnec"
825
  ],
826
  "lcnec": [
827
+ "and large cell neuroendocrine carcinoma",
828
+ "and\nlarge cell neuroendocrine carcinoma"
829
  ],
830
  "and thymic\ncarcinoid": [
831
  "thc"
832
  ],
833
  "thc": [
834
+ "and thymic\ncarcinoid",
835
+ "and thymic carcinoid"
836
  ],
837
  "org": [
838
  "esmo guidelines committee"
 
888
  "ssas"
889
  ],
890
  "ssas": [
 
891
  "medical options",
892
+ "-labelled somatostatin analogues",
893
  "what is the role of somatostatin analogues"
894
  ],
895
  "urinary-free cortisol": [
 
935
  "cht"
936
  ],
937
  "cht": [
 
938
  "the addition of the chemotherapy",
 
 
939
  "over platinum-based doublet\nchemotherapy",
940
+ "mainly cytotoxic chemotherapy",
941
+ "chemotherapy",
942
+ "platinum-based chemo\ntherapy",
943
  "with or without prior adjuvant chemotherapy",
944
+ "over platinum-based doublet chemotherapy",
945
+ "platinum-based chemotherapy",
946
+ "the beneficial effects of adjuvant chemotherapy"
947
  ],
948
  "or systemic therapies": [
949
+ "with options\ndiscussed in these guidelines",
950
+ "with options discussed in these guidelines"
951
  ],
952
  "with options\ndiscussed in these guidelines": [
953
  "or systemic therapies"
 
956
  "functioning syndrome"
957
  ],
958
  "functioning syndrome": [
959
+ "in case of clinical",
960
+ "in case of\nclinical"
961
  ],
962
  "and the united states food and drug administration": [
963
  "fda"
 
973
  "rfa"
974
  ],
975
  "rfa": [
976
+ "for these patients radiofrequency ablation",
977
  "palliative surgery\nor radiofrequency ablation",
978
+ "palliative surgery or radiofrequency ablation"
 
979
  ],
980
  "or cryoablation or endobronchial treatment": [
981
  "ebt"
 
987
  "prrt"
988
  ],
989
  "prrt": [
990
+ "peptide receptor radionuclide therapy",
991
+ "peptide\nreceptor radionuclide therapy"
992
  ],
993
  "and interferon- a": [
994
  "ifna"
 
1040
  "-fluorouracil"
1041
  ],
1042
  "as alternative second-line": [
1043
+ "in case of uncontrolled cs",
1044
+ "in case of\nuncontrolled cs"
1045
  ],
1046
  "in case of\nuncontrolled cs": [
1047
  "as alternative second-line"
 
1074
  "thymic net recurrences may be local"
1075
  ],
1076
  "regional": [
1077
+ "intrathoracic especially pleural",
1078
+ "intrathoracic especially\npleural"
1079
  ],
1080
  "intrathoracic especially\npleural": [
1081
  "regional"
 
1085
  ],
1086
  "esmo-mcbs": [
1087
  "esmo-magnitude of clinical\nbenefit",
 
 
 
1088
  "an esmo\nmagnitude of clinical benefit scale",
1089
  "esmo-magnitude of clinical benefit",
1090
+ "esmomagnitude of clinical benefit scale",
1091
+ "an esmo magnitude of clinical benefit scale",
1092
+ "esmo-magnitude of clinical benefit scale",
1093
+ "esmo-magnitude of\nclinical benefit"
1094
  ],
1095
  "advanced carcinoids of the lung and thymus": [
1096
  "luna"
 
1144
  "chuv"
1145
  ],
1146
  "chuv": [
1147
+ "centre hospitalier universitaire\nvaudois",
1148
+ "centre hospitalier universitaire vaudois"
1149
  ],
1150
  "comparing low-dose computed tomography": [
1151
  "ldct"
1152
  ],
1153
  "ldct": [
1154
+ "low-dose ct",
1155
+ "comparing low-dose computed tomography"
1156
  ],
1157
  "such as lepidic adenocarcinomas": [
1158
  "previously named bronchioloalveolar carcinoma"
 
1177
  "who"
1178
  ],
1179
  "who": [
1180
+ "the recent world health organization",
1181
  "world health organization",
 
1182
  "global",
1183
+ "vs universal",
1184
+ "global statistics"
1185
  ],
1186
  "with its further sub-classification of": [
1187
  "surgically resected"
 
1196
  "ais"
1197
  ],
1198
  "ais": [
 
1199
  "proposed that ais be classified as tis",
1200
+ "the categories adenocarcinoma in situ",
1201
  "proposed\nthat ais be classified as tis"
1202
  ],
1203
  "minimally invasive adenocarcinoma": [
 
1229
  "uicc"
1230
  ],
1231
  "uicc": [
1232
+ "union for international cancer control",
 
1233
  "union for international\ncancer control",
1234
+ "the union for international cancer control",
1235
+ "the union for\ninternational cancer control"
1236
  ],
1237
  "node and metastasis": [
1238
  "tnm"
1239
  ],
1240
  "tnm": [
1241
+ "node and metastasis",
1242
  "tumour-node-metastasis",
1243
+ "tumourenodeemetastasis"
1244
  ],
1245
  "proposed\nthat ais be classified as tis": [
1246
  "ais"
 
1268
  "accp"
1269
  ],
1270
  "accp": [
1271
+ "the\namerican college of chest physicians",
1272
  "whereas the american college of chest physicians",
1273
+ "the american college of chest physicians"
1274
  ],
1275
  "adjuvant chemotherapy": [
1276
  "radiotherapy"
 
1282
  "vats"
1283
  ],
1284
  "vats": [
1285
+ "video-assisted thoracic surgery",
1286
+ "or a video-assisted thoracoscopic surgery"
1287
  ],
1288
  "based on the lung cancer study group": [
1289
  "lcsg"
 
1347
  "neo"
1348
  ],
1349
  "neo": [
1350
+ "the\nimmune strategy in the",
1351
  "- immunotherapy is being studied in early nsclc as",
1352
  "immunotherapy is being studied in early nsclc as",
1353
+ "resection and after",
1354
  "the immune strategy in the"
1355
  ],
1356
  "cl\n\ntreatment of locally advanced stage": [
 
1385
  ],
1386
  "ests": [
1387
  "and the european\nsociety of thoracic surgeons",
1388
+ "and the european society of thoracic surgeons",
1389
+ "and european society of thoracic surgeons"
1390
  ],
1391
  "gv scagliotti": [
1392
  "eds"
 
1408
  "pulmonology"
1409
  ],
1410
  "pulmonology": [
1411
+ "respiratory oncology",
1412
+ "respiratory oncology unit"
1413
  ],
1414
  "edegem": [
1415
  "antwerp"
 
1430
  "stage iii"
1431
  ],
1432
  "stage iii": [
1433
+ "locally advanced nsclc",
1434
+ "- locally advanced nsclc",
1435
  "unresectable nsclc",
1436
  "treatment of locally advanced stage",
1437
+ "and unresectable locally advanced"
 
1438
  ],
1439
  "in paral\npractice guidelines": [
1440
  "cpgs"
 
1446
  "see panel members listed in the appendix"
1447
  ],
1448
  "see panel members listed in the appendix": [
 
1449
  "experts were involved in this consensus process",
1450
+ "and a general consen\nconsensus process",
1451
+ "experts were involved in this\nconsensus process"
1452
  ],
1453
  "experts were involved in this\nconsensus process": [
1454
  "see panel members listed in the appendix"
 
1466
  "as relative value depends on personal"
1467
  ],
1468
  "respiratory literature": [
1469
+ "especially on exercise testing",
1470
+ "especially on exercise\ntesting"
1471
  ],
1472
  "especially on exercise\ntesting": [
1473
  "respiratory literature"
 
1581
  "pbc"
1582
  ],
1583
  "pbc": [
1584
+ "platinum-based doublet chemotherapy",
1585
  "five cycles of tremelimumab",
1586
+ "five cycles of\n\ntremelimumab"
 
1587
  ],
1588
  "carboplatin": [
1589
+ "arm a",
1590
+ "arm b"
1591
  ],
1592
  "arm a": [
1593
  "carboplatin"
 
1606
  "primary endpoint"
1607
  ],
1608
  "primary endpoint": [
1609
+ "-year os",
 
1610
  "pbc significantly improved pfs",
1611
  "level",
1612
+ "significantly improved os",
1613
+ "pbc\nsignificantly improved pfs"
1614
  ],
1615
  "besides immune checkpoint\n\ninhibitor": [
1616
  "ici"
1617
  ],
1618
  "ici": [
 
1619
  "besides immune checkpoint\n\ninhibitor",
1620
+ "and have no prior immune checkpoint inhibitor",
1621
+ "besides immune checkpoint inhibitor"
1622
  ],
1623
  "esmo-magnitude of clinical benefit scale": [
1624
+ "esmo-mcbs",
1625
+ "mcbs"
1626
  ],
1627
  "mcbs": [
1628
  "esmo-magnitude of clinical benefit scale"
 
1652
  "ttfields"
1653
  ],
1654
  "ttfields": [
1655
+ "tumour treating\nfields",
1656
+ "tumour treating fields"
1657
  ],
1658
  "significantly improved os": [
1659
  "primary endpoint"
 
1662
  "esmo guidelines staff"
1663
  ],
1664
  "esmo guidelines staff": [
1665
+ "jennifer\nlamarre and guy atchison",
1666
  "ioanna ntai and claire bramley",
1667
  "jennifer lamarre and guy atchison",
 
1668
  "valerie laforest"
1669
  ],
1670
  "valerie laforest": [
1671
+ "esmo\nguidelines staff",
1672
+ "esmo guidelines staff"
1673
  ],
1674
  "esmo\nguidelines staff": [
1675
  "valerie laforest"
 
1678
  "esmo scientific affairs staff"
1679
  ],
1680
  "esmo scientific affairs staff": [
1681
+ "nicola\nlatino",
 
 
1682
  "nicola\nlatino and francesca chiovaro",
1683
+ "nicola latino and\nfrancesca chiovaro",
1684
+ "nicola latino and francesca chiovaro",
1685
+ "nicola latino"
1686
  ],
1687
  "bristol\nmyers squibb": [
1688
  "bms"
 
1700
  "ipsos"
1701
  ],
1702
  "ipsos": [
1703
+ "roche and regimen",
1704
+ "with a platinum-containing\nregimen"
1705
  ],
1706
  "esmo clinical practice guideline": [
1707
  "cpg"
 
1719
  "ngs"
1720
  ],
1721
  "ngs": [
 
1722
  "by next-generation sequencing",
1723
+ "such as next-generation sequencing",
1724
+ "multiplex platforms"
1725
  ],
1726
  "egfr fish or immunohistochemistry": [
1727
  "ihc"
 
1733
  "ntrk"
1734
  ],
1735
  "ntrk": [
1736
+ "and the neurotrophic receptor tyrosine\nkinase",
 
1737
  "or neurotrophic tyrosine\nreceptor kinase",
1738
+ "- the neurotrophic receptor tyrosine kinase",
1739
+ "or neurotrophic tyrosine receptor kinase"
1740
  ],
1741
  "detection is reliable by\nin situ hybridisation": [
1742
  "ish"
1743
  ],
1744
  "ish": [
1745
+ "detection is reliable by\nin situ hybridisation",
1746
+ "detection is reliable by in situ hybridisation"
1747
  ],
1748
  "mesenchymal-epithelial transition": [
1749
  "met"
 
1781
  "fdg"
1782
  ],
1783
  "fdg": [
1784
+ "-deoxy-d-glucose",
1785
+ "e\ndeoxy-d-glucose"
1786
  ],
1787
  "union for international\ncancer control": [
1788
  "uicc"
 
1811
  "mos"
1812
  ],
1813
  "mos": [
 
1814
  "malaysian oncological society",
1815
  "malaysia",
1816
+ "the malaysian oncological society",
1817
+ "and median os"
1818
  ],
1819
  "systemic progression\n\nlocal treatment": [
1820
  "surgery or ft"
 
1848
  "japan"
1849
  ],
1850
  "japan": [
1851
+ "j-alex",
1852
+ "jsmo"
1853
  ],
1854
  "and\nalesia": [
1855
  "asia"
1856
  ],
1857
  "asia": [
1858
+ "and alesia",
1859
+ "and\nalesia"
1860
  ],
1861
  "and continue targeted": [
1862
  "not mandatory for decision"
 
1889
  "mdor"
1890
  ],
1891
  "mdor": [
1892
+ "the median duration of response",
1893
+ "the\nmedian duration of response"
1894
  ],
1895
  "tropomyosin receptor tyrosine kinase": [
1896
  "trk"
 
1902
  "surgery or rt"
1903
  ],
1904
  "surgery or rt": [
1905
+ "- local treatment",
1906
  "oligoprogression\n\nlocal treatment",
1907
  "local treatment",
 
1908
  "disease progression\n\nlocal treatment"
1909
  ],
1910
  "or combination therapy with a mek inhibitor": [
 
1932
  "kras"
1933
  ],
1934
  "kras": [
1935
+ "the\nkirsten rat sarcoma virus",
1936
+ "the kirsten rat sarcoma virus"
1937
  ],
1938
  "data regarding the role of local ablative therapy": [
1939
  "lat"
 
1972
  "esmo scientific affairs staff"
1973
  ],
1974
  "and dr svetlana jezdic": [
 
1975
  "esmo medical affairs advisor",
1976
+ "esmo\nmedical affairs advisor",
1977
  "esmo medical affairs staff"
1978
  ],
1979
  "esmo\nmedical affairs advisor": [
 
1986
  "atorg"
1987
  ],
1988
  "atorg": [
1989
+ "asian thoracic oncology research group",
1990
+ "asian\nthoracic oncology research group"
1991
  ],
1992
  "chinese lung\ncancer research foundation limited": [
1993
  "clcrf"
 
2062
  "asmac"
2063
  ],
2064
  "asmac": [
2065
+ "s de clinique",
2066
+ "s\nde clinique"
2067
  ],
2068
  "rzte": [
2069
  "vsao"
 
2084
  "cancers"
2085
  ],
2086
  "relay": [
2087
+ "cancer",
2088
+ "advanced non-small-cell lung cancer"
2089
  ],
2090
  "non-small-cell lung cancer": [
2091
+ "nsclc",
2092
+ "alesia"
2093
  ],
2094
  "alesia": [
2095
  "non-small-cell lung cancer"
 
2111
  "chmp"
2112
  ],
2113
  "chmp": [
 
2114
  "products for human use",
2115
+ "retsevmo - summary of opinion",
2116
+ "tabrecta - summary of opinion"
2117
  ],
2118
  "tabrecta - summary of opinion": [
2119
  "chmp"
 
2150
  ],
2151
  "jsmo": [
2152
  "the\njapanese society of medical oncology",
2153
+ "japan",
2154
+ "the japanese society of medical oncology"
2155
  ],
2156
  "korea": [
2157
  "ksmo"
 
2166
  "psmo"
2167
  ],
2168
  "psmo": [
 
2169
  "and philippine society of medical oncology",
 
2170
  "and philippine society of medical\noncology",
2171
+ "the philippine society of medical oncology",
2172
+ "the philippines",
2173
  "the philippine society of\nmedical oncology"
2174
  ],
2175
  "singapore": [
 
2184
  "tos"
2185
  ],
2186
  "tos": [
2187
+ "taiwan",
2188
+ "the taiwan oncology society"
2189
  ],
2190
  "and thailand": [
2191
  "tsco"
2192
  ],
2193
  "tsco": [
 
2194
  "and the\nthai society of clinical oncology",
2195
+ "and thailand",
2196
  "and the thai society of clinical oncology"
2197
  ],
2198
  "and the neurotrophic receptor tyrosine\nkinase": [
 
2229
  "tmk and hrk"
2230
  ],
2231
  "tmk and hrk": [
2232
+ "only two of the six\nexpert members from the ksmo",
2233
+ "only two of the six expert members from the ksmo"
2234
  ],
2235
  "performance status": [
2236
  "ecog ps"
 
2266
  "such as osimertinib"
2267
  ],
2268
  "such as osimertinib": [
2269
+ "generation tki",
2270
+ "third-generation egfr tkis"
2271
  ],
2272
  "generation tki": [
2273
  "such as osimertinib"
 
2306
  "traes"
2307
  ],
2308
  "traes": [
2309
+ "treatment-related adverse events",
2310
  "what are the treatment-related adverse events",
2311
+ "treatment-related aes"
2312
  ],
2313
  "and have no prior immune checkpoint inhibitor": [
2314
  "ici"
 
2326
  "jkn"
2327
  ],
2328
  "jkn": [
2329
+ "ishmo\n\n\nthe jaminan kesehatan nasional",
2330
+ "ishmo\n\nthe jaminan kesehatan nasional"
2331
  ],
2332
  "there is no regulation of partial coverage": [
2333
  "co-payment"
 
2339
  "pap"
2340
  ],
2341
  "pap": [
2342
+ "esmo open\n\n\n\nprogram",
2343
+ "program"
2344
  ],
2345
  "mandatory national health insurance": [
2346
  "nhi"
 
2368
  "alk inhibitors"
2369
  ],
2370
  "and atezolizumab": [
2371
+ "in the\nsecond-line setting",
2372
+ "in the second-line setting"
2373
  ],
2374
  "in the\nsecond-line setting": [
2375
  "and atezolizumab"
 
2385
  "first-line"
2386
  ],
2387
  "first-line": [
2388
+ "and the alk inhibitors ceritinib and brigatinib",
2389
+ "and the alk inhibitors ceritinib and\nbrigatinib"
2390
  ],
2391
  "german": [
2392
  "merck"
 
2395
  "torg"
2396
  ],
2397
  "torg": [
2398
+ "thoracic oncology research\ngroup",
2399
+ "thoracic oncology research group"
2400
  ],
2401
  "and west japan oncology group": [
2402
  "wjog"
 
2405
  "and west japan oncology group"
2406
  ],
2407
  "product samples": [
2408
+ "nonrenumerated",
2409
+ "non-renumerated"
2410
  ],
2411
  "nonrenumerated": [
2412
  "product samples"
 
2479
  "mnsclc"
2480
  ],
2481
  "mnsclc": [
2482
+ "e-mutant metastatic nsclc",
2483
+ "stage iv metastatic non-small-cell lung cancer"
2484
  ],
2485
  "binimetinib in patients": [
2486
  "pts"
2487
  ],
2488
  "pts": [
 
2489
  "patients",
 
 
 
2490
  "mo encorafenib plus binimetinib in patients",
2491
  "binimetinib in patients",
2492
+ "therapy in patients",
2493
+ "p repotrectinib in patients",
2494
+ "osimertinib as adjuvant therapy in patients",
2495
+ "versus docetaxel in patients",
2496
+ "mo encorafenib plus\n\nbinimetinib in patients"
2497
  ],
2498
  "mutant advanced non-small cell lung cancer": [
2499
  "nsclc"
 
2509
  ],
2510
  "treatment of early stages": [
2511
  "stages i-ii",
2512
+ "stages i-iiia",
2513
+ "stages i and ii"
2514
  ],
2515
  "stages i-iiia": [
2516
  "treatment of early stages"
 
2523
  ],
2524
  "chemotherapy": [
2525
  "- everolimus\n - cht",
2526
+ "cht",
2527
+ "adaura"
2528
  ],
2529
  "the median\nwas not reached": [
2530
  "ne-ne"
 
2543
  "neo"
2544
  ],
2545
  "or docetaxel or pemetrexed": [
2546
+ "only in adenocarcinoma tumours",
2547
+ "only in\nadenocarcinoma tumours"
2548
  ],
2549
  "only in\nadenocarcinoma tumours": [
2550
  "or docetaxel or pemetrexed"
 
2553
  "port"
2554
  ],
2555
  "port": [
2556
+ "postoperative radiotherapy",
2557
  "post-operative radiotherapy",
2558
+ "comparing post-operative conformal radiotherapy"
2559
  ],
2560
  "treatment of locally advanced stage": [
2561
  "stage iii"
 
2594
  "pacific"
2595
  ],
2596
  "pacific": [
 
2597
  "concurrent chemoradiation therapy",
2598
+ "unresectable non-small-cell lung cancer",
2599
+ "small-cell lung cancer"
2600
  ],
2601
  "adaura": [
2602
  "chemotherapy"
 
2605
  "including stage ib"
2606
  ],
2607
  "including stage ib": [
2608
+ "d approval was based on all patient data",
2609
+ "approval was based on all patient data"
2610
  ],
2611
  "on tumour cells": [
2612
  "as per the\nema-approved indication",
 
2649
  "egfrm"
2650
  ],
2651
  "nivolumab": [
2652
+ "nivo",
2653
+ "bristol myers squibb statement on opdivo"
2654
  ],
2655
  "nivo": [
2656
  "nivolumab"
 
2659
  "chemo"
2660
  ],
2661
  "chemo": [
2662
+ "platinum-based chemotherapy",
2663
  "platinum-doublet chemotherapy",
2664
+ "platinum-doublet\nchemotherapy"
 
2665
  ],
2666
  "for\nresectable": [
2667
  "ib-iiia"
2668
  ],
2669
  "ib-iiia": [
2670
+ "for resectable",
2671
+ "for\nresectable"
2672
  ],
2673
  "lung cancer": [
2674
  "nsclc"
 
2692
  "diques august pi i sunyer"
2693
  ],
2694
  "department of radiation oncology": [
2695
+ "maastro clinic",
2696
+ "maastro"
2697
  ],
2698
  "maastro clinic": [
2699
  "department of radiation oncology"
 
3215
  "rfa"
3216
  ],
3217
  "peptide receptor radionuclide therapy": [
3218
+ "- prrt",
3219
+ "prrt"
3220
  ],
3221
  "what is the role of somatostatin analogues": [
3222
  "ssas"
 
3423
  "fda"
3424
  ],
3425
  "the median duration of response": [
3426
+ "mdor",
3427
+ "dor"
3428
  ],
3429
  "deruxtecan": [
3430
  "fda approved"
 
3535
  "author"
3536
  ],
3537
  "author": [
3538
+ "hrk",
3539
+ "cew",
3540
  "jchy",
3541
+ "sak",
3542
  "msi",
3543
  "tmk",
3544
+ "ddwl"
 
 
 
3545
  ],
3546
  "hrk": [
3547
  "author"
 
3661
  },
3662
  "abbreviations": {
3663
  "esmo": [
3664
+ "european society for medical oncology",
3665
+ "european society for medical\noncology",
3666
+ "the european society for medical oncology",
3667
  "european\nsociety of medical oncology",
3668
  "the following european society for medical oncology",
3669
+ "the most recent european society for medical oncology",
 
3670
  "living guideline\n\nthe following european society for medical oncology",
 
3671
  "european society for\nmedical oncology",
3672
+ "european society of medical oncology"
 
3673
  ],
3674
  "asco": [
 
3675
  "american society of clinical\n\noncology",
 
 
 
3676
  "journal of clinical oncology",
3677
+ "american society of clinical\noncology",
3678
+ "american\nsociety of clinical oncology",
3679
+ "the clinical practice guidelines published herein are provided by the american society of clinical oncology inc",
3680
+ "american society of clinical oncology",
3681
+ "this american society of clinical oncology"
3682
  ],
3683
  "aiom": [
3684
+ "the italian association of medical oncology",
3685
  "italian association of medical oncology",
3686
+ "italian association\nof medical oncology"
3687
  ],
3688
  "nccn": [
3689
+ "national comprehensive cancer network",
3690
+ "american cancer centers"
3691
  ],
3692
  "glides": [
3693
+ "ecision support",
3694
  "guidelines into decision\nsupport",
3695
+ "guidelines into decision support"
 
3696
  ],
3697
  "glc": [
3698
  "guidelines committee"
3699
  ],
3700
  "mcbs": [
3701
+ "magnitude of clinical benefit scale",
3702
  "magnitude\nof clinical benefit score",
3703
+ "magnitude of clinical benefit score"
3704
  ],
3705
  "ema": [
3706
  "european medicines\nagency",
3707
  "european medicines agency"
3708
  ],
3709
  "sclc": [
 
 
3710
  "what is the treatment algorithm for patients with small cell lung cancer",
3711
+ "small cell lung cancer",
3712
  "clinical practice guidelines on small cell lung\ncancer",
3713
+ "clinical practice guidelines on small cell lung cancer",
3714
  "what are the recommended treatment options for patients with relapsed small cell lung cancer"
3715
  ],
3716
  "cco": [
3717
  "cancer care ontario"
3718
  ],
3719
  "astro": [
3720
+ "executive summary of an american society for\nradiation oncology",
3721
+ "executive summary of an american society for radiation oncology"
3722
  ],
3723
  "inst": [
3724
+ "advaxis",
3725
+ "bristol myers squibb",
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
3726
  "blueprint medicines",
3727
+ "dizal pharma",
3728
+ "astex pharmaceuticals",
 
 
3729
  "revolution medicines",
3730
+ "black diamond therapeutics",
3731
+ "verastem",
3732
+ "heart therapeutics",
3733
+ "sutro biopharma",
3734
+ "novartis",
3735
+ "bristol myers\nsquibb",
3736
+ "merck",
3737
+ "black diamond\ntherapeutics",
3738
+ "therapeutics",
3739
+ "guardant health",
3740
+ "jazz pharmaceuticals",
3741
+ "amgen",
3742
+ "calithera biosciences",
3743
+ "genomics",
3744
  "dohme",
3745
+ "astra zeneca",
3746
  "harpoon therapeutics",
3747
+ "pfizer",
3748
+ "zeneca canada",
3749
  "kline canada",
3750
+ "nuvation bio",
3751
+ "turning point therapeutics",
3752
+ "trizell",
3753
+ "immune",
3754
+ "roche",
3755
+ "arcus biosciences",
3756
+ "summit therapeutics",
3757
+ "myers squibb",
3758
+ "lilly",
3759
+ "forward",
3760
+ "regeneron",
3761
  "takeda",
 
 
 
 
 
3762
  "dizal\npharma",
3763
+ "kline",
3764
+ "janssen oncology",
3765
+ "polaris",
3766
+ "mirati therapeutics",
3767
  "puma biotechnology",
3768
+ "cullinan oncology",
3769
+ "constellation pharmaceuticals",
3770
  "vivace therapeutics",
3771
+ "palobiofarma",
3772
+ "bristol myers squibb foundation",
 
 
3773
  "bayer",
 
 
 
 
 
 
 
 
 
 
 
3774
  "pharmaceuticals",
3775
+ "boehringer ingelheim",
3776
+ "inhibrx",
3777
+ "exelixis",
3778
+ "merck serono",
3779
+ "janssen",
3780
+ "macrogenics",
3781
+ "zeneca",
3782
+ "elevation oncology",
3783
+ "genentech"
3784
  ],
3785
  "ct": [
 
 
3786
  "the use of\ncomputed tomography",
3787
+ "clinicians should use a diagnostic chest computed tomography",
3788
+ "the use of computed tomography",
3789
+ "computed tomography"
3790
  ],
3791
  "mri": [
3792
  "what is the role of brain magnetic resonance imaging"
3793
  ],
3794
  "sbrt": [
3795
+ "stereotactic body radiotherapy",
3796
+ "salvage stereotactic body radiation therapy"
3797
  ],
3798
  "cap": [
3799
  "pathologists",
3800
  "college of american pathologists"
3801
  ],
3802
  "iaslc": [
3803
+ "international association for the\n\nstudy of lung cancer",
3804
+ "international association for\nthe study of lung cancer",
3805
+ "the international association for the study of lung cancer",
3806
+ "the\ninternational association for the study of lung cancer",
3807
  "pathology committee chair for international association for the study of lung cancer",
3808
  "study of lung cancer",
 
3809
  "pathology committee chair\nfor international association for the study of lung cancer",
 
3810
  "international association for the study of lung cancer",
3811
+ "international association for the\nstudy of lung cancer"
 
 
3812
  ],
3813
  "amp": [
3814
+ "association for molecular pathology",
3815
+ "association\nfor molecular pathology"
3816
  ],
3817
  "ihc": [
3818
  "immunohistochemistry"
 
3824
  "although the results from the mesothelioma and radical surgery"
3825
  ],
3826
  "os": [
 
 
3827
  "overall survival",
3828
  "the median overall survival",
3829
+ "the only data published thus far pertain to the dual primary end points of overall survival",
3830
+ "the median\noverall survival",
3831
+ "median overall survival"
3832
  ],
3833
  "elsevier": [
3834
  "clinical lung cancer"
 
3837
  "one randomized controlled trial"
3838
  ],
3839
  "ps": [
3840
+ "eastern cooperative oncology group performance status",
3841
+ "eastern cooperative oncology group performance\nstatus"
3842
  ],
3843
  "orr": [
3844
  "is result in a lower overall response\nrate",
 
3845
  "is result in a lower overall response rate",
3846
+ "objective response rate",
3847
  "reuss et al\n\n\n\nrate"
3848
  ],
3849
  "pci": [
3850
+ "what is the role of prophylactic cranial irradiation",
3851
+ "prophylactic cranial irradiation"
3852
  ],
3853
  "fda": [
 
3854
  "entrectinib received food and drug administration",
3855
+ "entrectinib received food and\ndrug administration",
 
3856
  "osimertinib is approved by both the united states food and\ndrug administration",
3857
+ "these results led to the food\n\nand drug administration",
3858
+ "food and drug administration",
3859
+ "osimertinib is approved by both the united states food and drug administration",
3860
+ "united states food and drug administration"
3861
  ],
3862
  "crs": [
3863
  "cytokine release syndrome"
 
3866
  "department of surgical sciences"
3867
  ],
3868
  "who": [
3869
+ "the recent world health organization",
3870
  "world health organization",
 
3871
  "global",
3872
+ "the latest world health organization",
3873
+ "global statistics"
3874
  ],
3875
  "lc": [
3876
+ "these\nguidelines are restricted to lung carcinoid",
3877
+ "these guidelines are restricted to lung carcinoid"
3878
  ],
3879
  "seer": [
3880
+ "end results",
3881
+ "epidemiology and end results"
3882
  ],
3883
  "uicc": [
3884
+ "edition of the union for international cancer control",
3885
  "edition of the union for\ninternational cancer control",
3886
+ "union for\ninternational cancer control",
3887
  "union for international cancer control",
3888
+ "union for international\ncancer control"
 
 
3889
  ],
3890
  "gep": [
3891
+ "based on approval and recommendations in gastroenteropancreatic",
3892
+ "based on\napproval and recommendations in gastroenteropancreatic"
3893
  ],
3894
  "pth": [
3895
  "annals of oncology\n\n\n\nparathyroid hormone"
3896
  ],
3897
  "rfa": [
3898
+ "for these patients radiofrequency ablation",
3899
  "palliative surgery\nor radiofrequency ablation",
3900
+ "palliative surgery or radiofrequency ablation"
 
3901
  ],
3902
  "recist": [
3903
  "cs with response evaluation criteria in solid tumours",
3904
+ "cs with response evaluation criteria\nin solid tumours",
3905
  "measurements and response assessment should follow response evaluation criteria in solid tumours",
3906
+ "measurements and response assessment should follow\nresponse evaluation criteria in solid tumours"
3907
  ],
3908
  "gemox": [
3909
  "oxaliplatin combined with gemcitabine"
 
3912
  "lanreotide autogel"
3913
  ],
3914
  "chuv": [
3915
+ "centre hospitalier universitaire\nvaudois",
3916
+ "centre hospitalier universitaire vaudois"
3917
  ],
3918
  "nlst": [
3919
  "the much larger national lung cancer screening trial",
 
3964
  "the thoracic surgery scoring\nsystem"
3965
  ],
3966
  "pulmonology": [
3967
+ "respiratory oncology",
3968
+ "respiratory oncology unit"
3969
  ],
3970
  "acs": [
3971
+ "lung cancer screening guidelines published by the\namerican cancer society",
3972
+ "lung cancer screening guidelines published by the american cancer society"
3973
  ],
3974
  "ialt": [
3975
  "some trials"
 
3978
  "adjuvant navelbine international trialist association"
3979
  ],
3980
  "sabr": [
3981
+ "consolidative stereotactic ablative radiotherapy",
3982
  "what are the indications and recommendations for salvage surgery after stereotactic ablative radiotherapy",
 
3983
  "what are the outcomes comparing stereotactic ablative radiotherapy",
3984
+ "radiographic changes after lung stereotactic ablative radiotherapy",
3985
+ "radiographic changes after lung stereotactic\nablative radiotherapy"
3986
  ],
3987
  "vumc": [
3988
  "vrije\nuniversity medical centre",
 
3993
  "bemeneed"
3994
  ],
3995
  "bms": [
3996
+ "bristol myers squibb",
3997
  "myers\nsquibb",
3998
+ "myers squibb",
3999
  "bristol myers\nsquibb",
4000
+ "bristol\nmyers squibb"
 
 
4001
  ],
4002
  "msd": [
4003
  "dohme"
4004
  ],
4005
  "eortc": [
 
4006
  "chair of the european\norganisation for research and treatment of cancer",
4007
+ "european\norganisation for research and treatment of cancer",
4008
  "treatment of cancer",
4009
+ "european organisation for research and treatment of cancer",
4010
+ "chair of the european organisation for research and treatment of cancer"
4011
  ],
4012
  "cpg": [
4013
  "clinical practice guideline"
4014
  ],
4015
  "escat": [
4016
  "scale for clinical actionability of\nmolecular targets",
4017
+ "targets",
4018
+ "scale for clinical actionability of molecular targets"
4019
  ],
4020
  "alk": [
4021
  "positive anaplastic lymphoma kinase"
4022
  ],
4023
  "ish": [
4024
+ "detection is reliable by\nin situ hybridisation",
4025
+ "detection is reliable by in situ hybridisation"
4026
  ],
4027
  "cns": [
4028
  "imaging of the central nervous system"
 
4041
  "interstitial lung disease"
4042
  ],
4043
  "kras": [
4044
+ "the\nkirsten rat sarcoma virus",
4045
+ "the kirsten rat sarcoma virus"
4046
  ],
4047
  "lat": [
4048
  "data regarding the role of local ablative therapy"
 
4058
  "lung cancer group and past secretary and current\nchair of the nederlandse vereniging van artsen voor longziekten en tuberculose"
4059
  ],
4060
  "atorg": [
4061
+ "asian thoracic oncology research group",
4062
+ "asian\nthoracic oncology research group"
4063
  ],
4064
  "clcrf": [
4065
  "chinese lung\ncancer research foundation limited",
4066
  "chinese lung cancer research foundation limited"
4067
  ],
4068
  "csco": [
 
4069
  "chinese society of clinical oncology",
4070
+ "china",
4071
+ "chinese\nsociety of clinical oncology"
4072
  ],
4073
  "hkcf": [
4074
  "hong kong cancer fund"
 
4087
  "research to practice"
4088
  ],
4089
  "samo": [
4090
+ "president of swiss academy of multidisciplinary oncology",
4091
+ "president of swiss\nacademy of multidisciplinary oncology"
4092
  ],
4093
  "sakk": [
4094
  "research",
4095
+ "president of lung group for swiss group for clinical cancer research",
4096
+ "president of lung group for swiss group for clinical cancer\nresearch"
4097
  ],
4098
  "etop": [
4099
  "european thoracic oncology platform"
 
4102
  "international breast cancer study group"
4103
  ],
4104
  "aacr": [
4105
+ "partners member\nof american association of cancer research",
4106
+ "partners member of american association of cancer research"
4107
  ],
4108
  "asmac": [
4109
  "clinique"
 
4113
  ],
4114
  "chmp": [
4115
  "summary of opinion",
4116
+ "products for human use",
4117
+ "committee for medicinal products for human use"
4118
  ],
4119
  "paga": [
4120
  "asian adapted"
4121
  ],
4122
  "ishmo": [
 
4123
  "indonesian society\nof hematology and medical oncology",
4124
+ "indonesian society of hematology and medical oncology",
4125
+ "indonesia"
4126
  ],
4127
  "jsmo": [
4128
+ "japan",
4129
+ "japanese society of medical oncology"
4130
  ],
4131
  "ksmo": [
4132
  "korea",
 
4137
  "malaysia"
4138
  ],
4139
  "psmo": [
 
 
4140
  "philippines",
4141
+ "philippine society of medical\noncology",
4142
+ "philippine society of\nmedical oncology",
4143
  "philippine society of medical oncology"
4144
  ],
4145
  "sso": [
 
4148
  "singapore"
4149
  ],
4150
  "tos": [
4151
+ "taiwan",
4152
+ "taiwan oncology society"
4153
  ],
4154
  "tsco": [
4155
  "thai society of clinical oncology",
 
4163
  "national medical products\nadministration"
4164
  ],
4165
  "nmpa": [
4166
+ "chinese national\nmedical products administration",
4167
+ "chinese national medical products administration"
4168
  ],
4169
  "jkn": [
4170
  "the jaminan kesehatan nasional"
4171
  ],
4172
  "fornas": [
 
4173
  "national standard of medication list",
4174
  "national standard of\nmedication list",
4175
+ "national drug formulary",
4176
+ "na\ntional drug formulary"
4177
  ],
4178
  "pap": [
4179
  "open\n\n\n\nprogram"
4180
  ],
4181
  "pdma": [
4182
+ "it may take from several months to years for the pharmaceuticals and medical devices agency",
4183
+ "it may take\nfrom several months to years for the pharmaceuticals and\nmedical devices agency"
4184
  ],
4185
  "nhi": [
4186
  "national health insurance"
4187
  ],
4188
  "torg": [
4189
+ "thoracic oncology research\ngroup",
4190
+ "thoracic oncology research group"
4191
  ],
4192
  "wjog": [
4193
  "west japan oncology group"
 
4196
  "trial steering committee"
4197
  ],
4198
  "idmc": [
4199
+ "independent data monitoring committee",
4200
+ "committee"
4201
  ],
4202
  "ukiog": [
4203
  "ireland oesophagogastric group"
 
4295
  "diffuse idiopathic pulmonary neuroendocrine cell hyperplasia"
4296
  ],
4297
  "port": [
 
 
4298
  "what is the current evidence and recommendation for postoperative radiotherapy",
4299
+ "postoperative radiotherapy",
4300
+ "what are the outcomes and recommendations for postoperative radiotherapy",
4301
+ "radiotherapy"
4302
  ],
4303
  "i-v": [
4304
  "classification system showing five levels of evidence"
logs/app.log CHANGED
@@ -9262,3 +9262,66 @@ ImportError: cannot import name 'store_user_question' from 'core.tools' (d:\Work
9262
  2025-11-16 14:31:54,318 - AgenticMedicalRAG - INFO - LLM initialized successfully
9263
  2025-11-16 14:31:54,319 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: All components initialized successfully (100%)
9264
  2025-11-16 14:31:54,319 - AgenticMedicalRAG - INFO - βœ… Background initialization completed successfully
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
9262
  2025-11-16 14:31:54,318 - AgenticMedicalRAG - INFO - LLM initialized successfully
9263
  2025-11-16 14:31:54,319 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: All components initialized successfully (100%)
9264
  2025-11-16 14:31:54,319 - AgenticMedicalRAG - INFO - βœ… Background initialization completed successfully
9265
+ 2025-11-17 18:58:17,162 - AgenticMedicalRAG - INFO - Configuration validation completed
9266
+ 2025-11-17 18:58:18,680 - AgenticMedicalRAG - INFO - Loaded 1085 learned synonyms from cache
9267
+ 2025-11-17 18:58:19,132 - AgenticMedicalRAG - INFO - πŸš€ Starting background initialization...
9268
+ 2025-11-17 18:58:19,133 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: Starting background initialization... (0%)
9269
+ 2025-11-17 18:58:19,134 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: Loading embedding model... (10%)
9270
+ 2025-11-17 18:58:19,134 - AgenticMedicalRAG - INFO - Loading embedding model (first time)...
9271
+ 2025-11-17 18:58:26,904 - AgenticMedicalRAG - INFO - Embedding model loaded successfully
9272
+ 2025-11-17 18:58:26,905 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: Embedding model loaded successfully (40%)
9273
+ 2025-11-17 18:58:26,905 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: Initializing retrievers and loading chunks... (50%)
9274
+ 2025-11-17 18:58:26,905 - AgenticMedicalRAG - INFO - πŸ”„ Initializing retrievers (first time use)...
9275
+ 2025-11-17 18:58:26,905 - AgenticMedicalRAG - INFO - πŸ”„ Processing new data and updating vector store if needed...
9276
+ 2025-11-17 18:58:27,057 - AgenticMedicalRAG - INFO - πŸ“¦ Loading chunks cache for BM25 retriever...
9277
+ 2025-11-17 18:58:27,094 - AgenticMedicalRAG - INFO - πŸ” Creating vector retriever...
9278
+ 2025-11-17 18:58:27,095 - AgenticMedicalRAG - INFO - πŸ“ Creating BM25 retriever...
9279
+ 2025-11-17 18:58:27,964 - AgenticMedicalRAG - INFO - πŸ”„ Creating hybrid retriever...
9280
+ 2025-11-17 18:58:27,964 - AgenticMedicalRAG - INFO - βœ… Retrievers initialized successfully.
9281
+ 2025-11-17 18:58:27,964 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: Retrievers initialized successfully (90%)
9282
+ 2025-11-17 18:58:27,965 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: Learning medical terminology from corpus... (92%)
9283
+ 2025-11-17 18:58:31,275 - AgenticMedicalRAG - INFO - Saved learned terms to cache
9284
+ 2025-11-17 18:58:31,276 - AgenticMedicalRAG - INFO - Learned medical terminology from 1000 documents
9285
+ 2025-11-17 18:58:31,276 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: Warming up LLM... (97%)
9286
+ 2025-11-17 18:58:31,276 - AgenticMedicalRAG - INFO - Initializing LLM (first time)...
9287
+ 2025-11-17 18:58:32,024 - AgenticMedicalRAG - INFO - LLM initialized successfully
9288
+ 2025-11-17 18:58:32,025 - AgenticMedicalRAG - INFO - πŸ”„ Background Init: All components initialized successfully (100%)
9289
+ 2025-11-17 18:58:32,025 - AgenticMedicalRAG - INFO - βœ… Background initialization completed successfully
9290
+ 2025-11-17 18:59:13,558 - AgenticMedicalRAG - INFO - Processing user input (attempt 1): Give me the options for first line treatment for N...
9291
+ 2025-11-17 18:59:15,953 - AgenticMedicalRAG - INFO - No specific provider - querying each provider separately for balanced results
9292
+ 2025-11-17 18:59:15,953 - AgenticMedicalRAG - INFO - Querying provider: ASCO
9293
+ 2025-11-17 18:59:16,579 - AgenticMedicalRAG - INFO - Hybrid search returned 1 unique documents (query expansion: False)
9294
+ 2025-11-17 18:59:16,618 - AgenticMedicalRAG - INFO - Enriched 1 documents with surrounding context pages
9295
+ 2025-11-17 18:59:16,619 - AgenticMedicalRAG - INFO - Retrieved 1 documents from ASCO
9296
+ 2025-11-17 18:59:16,619 - AgenticMedicalRAG - INFO - Querying provider: ESMO
9297
+ 2025-11-17 18:59:16,693 - AgenticMedicalRAG - INFO - Hybrid search returned 6 unique documents (query expansion: False)
9298
+ 2025-11-17 18:59:16,696 - AgenticMedicalRAG - INFO - Enriched 1 documents with surrounding context pages
9299
+ 2025-11-17 18:59:16,697 - AgenticMedicalRAG - INFO - Retrieved 6 documents from ESMO
9300
+ 2025-11-17 18:59:16,697 - AgenticMedicalRAG - INFO - Querying provider: IASLC
9301
+ 2025-11-17 18:59:16,769 - AgenticMedicalRAG - INFO - Hybrid search returned 0 unique documents (query expansion: False)
9302
+ 2025-11-17 18:59:16,769 - AgenticMedicalRAG - INFO - Querying provider: NCCN
9303
+ 2025-11-17 18:59:16,842 - AgenticMedicalRAG - INFO - Hybrid search returned 0 unique documents (query expansion: False)
9304
+ 2025-11-17 18:59:16,842 - AgenticMedicalRAG - INFO - Querying provider: NICE
9305
+ 2025-11-17 18:59:16,912 - AgenticMedicalRAG - INFO - Hybrid search returned 5 unique documents (query expansion: False)
9306
+ 2025-11-17 18:59:16,915 - AgenticMedicalRAG - INFO - Enriched 1 documents with surrounding context pages
9307
+ 2025-11-17 18:59:16,916 - AgenticMedicalRAG - INFO - Retrieved 5 documents from NICE
9308
+ 2025-11-17 18:59:38,154 - AgenticMedicalRAG - INFO - Successfully processed user input: Give me the options for first line treatment for N...
9309
+ 2025-11-17 18:59:38,154 - AgenticMedicalRAG - INFO - Performing background validation...
9310
+ 2025-11-17 18:59:39,069 - AgenticMedicalRAG - INFO - Medical answer validator initialized successfully
9311
+ 2025-11-17 18:59:39,069 - AgenticMedicalRAG - INFO - GitHub token configured: ghp_KWH...dnCc
9312
+ 2025-11-17 18:59:39,069 - AgenticMedicalRAG - INFO - GitHub storage initialized for MoazEldsouky/cloud-data-store
9313
+ 2025-11-17 18:59:40,033 - AgenticMedicalRAG - INFO - Found 23 existing evaluations in GitHub
9314
+ 2025-11-17 18:59:40,033 - AgenticMedicalRAG - INFO - Next interaction ID will be: 24
9315
+ 2025-11-17 18:59:40,034 - AgenticMedicalRAG - INFO - Starting validation for interaction 24
9316
+ 2025-11-17 19:00:00,170 - AgenticMedicalRAG - INFO - Attempting to save evaluation with ID: 24
9317
+ 2025-11-17 19:00:00,170 - AgenticMedicalRAG - INFO - GitHub storage instance obtained, calling save_validation_results...
9318
+ 2025-11-17 19:00:00,171 - AgenticMedicalRAG - INFO - Attempt 1/3: Loading existing evaluations from GitHub...
9319
+ 2025-11-17 19:00:02,914 - AgenticMedicalRAG - INFO - Successfully loaded 23 existing evaluations
9320
+ 2025-11-17 19:00:02,915 - AgenticMedicalRAG - INFO - Adding new evaluation with ID: 24
9321
+ 2025-11-17 19:00:02,915 - AgenticMedicalRAG - INFO - Appended new evaluation. Total count: 24
9322
+ 2025-11-17 19:00:03,938 - AgenticMedicalRAG - INFO - Uploading to GitHub: medical_data/evaluation_results.json (size: 879332 bytes)
9323
+ 2025-11-17 19:00:08,498 - AgenticMedicalRAG - INFO - βœ“ Successfully uploaded medical_data/evaluation_results.json to GitHub
9324
+ 2025-11-17 19:00:08,500 - AgenticMedicalRAG - INFO - βœ“ Successfully saved evaluation 24. Total evaluations now: 24
9325
+ 2025-11-17 19:00:08,501 - AgenticMedicalRAG - INFO - βœ“ Evaluation saved to GitHub successfully with ID: 24
9326
+ 2025-11-17 19:00:08,502 - AgenticMedicalRAG - INFO - Background validation completed - Interaction ID: 24
9327
+ 2025-11-17 19:00:08,502 - AgenticMedicalRAG - INFO - Validation scores - Overall: 90/100, Accuracy: 95/100, Coherence: 90/100, Relevance: 88/100