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Browse files- core/__pycache__/agent.cpython-313.pyc +0 -0
- core/__pycache__/tools.cpython-313.pyc +0 -0
- core/agent.py +4 -4
- core/tools.py +4 -0
- data/medical_terms_cache.json +501 -501
- logs/app.log +63 -0
core/__pycache__/agent.cpython-313.pyc
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core/__pycache__/tools.cpython-313.pyc
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core/agent.py
CHANGED
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@@ -166,13 +166,13 @@ Your primary purpose is to provide evidence-based clinical guidance on lung canc
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**PART 1: INLINE CITATIONS** - Add a citation immediately after EACH section or statement in your answer:
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* After each clinical statement, recommendation, or data point, add an inline citation in parentheses
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-
* Format: (Source: [
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-
* Example: "Local authorities must use coordinated campaigns to raise awareness (Source: NICE, Page: 6, Provider: NICE)."
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* If a section uses multiple pages, cite each: "Structure measures include... (Page: 6). Process measures include... (Page: 15). Outcome measures include... (Page: 8)."
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| 173 |
**PART 2: COMPREHENSIVE CITATION LIST AT END** - After your complete answer, add a section titled "**References**" that lists ALL pages cited:
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-
* Format: (Source: [
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* Example: (Source: NICE, Pages: 6, 8, 15, Provider: NICE, Location: Quality Statement 1 - Structure, Process, and Outcome measures)
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- **PAGE CITATION RULE - EXTREMELY IMPORTANT**:
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* BEFORE writing your answer, review ALL retrieved pages (including context pages) and identify EVERY page that contains information you will use
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| 167 |
**PART 1: INLINE CITATIONS** - Add a citation immediately after EACH section or statement in your answer:
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* After each clinical statement, recommendation, or data point, add an inline citation in parentheses
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+
* Format: (Source: [Provider + full document title without file extension], Page: [page number], Provider: [provider])
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+
* Example: "Local authorities must use coordinated campaigns to raise awareness (Source: NICE Systemic anti-cancer therapy for advanced nonβsmallβcell lung cancer, Page: 6, Provider: NICE)."
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* If a section uses multiple pages, cite each: "Structure measures include... (Page: 6). Process measures include... (Page: 15). Outcome measures include... (Page: 8)."
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**PART 2: COMPREHENSIVE CITATION LIST AT END** - After your complete answer, add a section titled "**References**" that lists ALL pages cited:
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+
* Format: (Source: [Provider + full document title without file extension], Pages: [all page numbers in order], Provider: [provider name], Location: [specific sections/tables used])
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+
* Example: (Source: NICE Systemic anti-cancer therapy for advanced nonβsmallβcell lung cancer, Pages: 6, 8, 15, Provider: NICE, Location: Quality Statement 1 - Structure, Process, and Outcome measures)
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- **PAGE CITATION RULE - EXTREMELY IMPORTANT**:
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* BEFORE writing your answer, review ALL retrieved pages (including context pages) and identify EVERY page that contains information you will use
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core/tools.py
CHANGED
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@@ -184,6 +184,10 @@ def _build_citation(index: int, metadata: dict, content: str, include_provider:
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source = os.path.splitext(source)[0]
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page = metadata.get("page_number", "?")
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provider = metadata.get("provider", "unknown")
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disease = metadata.get("disease", "unknown")
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is_context = metadata.get("context_enrichment", False)
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source = os.path.splitext(source)[0]
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page = metadata.get("page_number", "?")
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provider = metadata.get("provider", "unknown")
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+
# Ensure source displays as "<PROVIDER> <file-stem>" unless it already starts with the provider
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+
if isinstance(source, str) and isinstance(provider, str) and provider and source:
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+
if not source.lower().startswith(provider.lower()):
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+
source = f"{provider} {source}"
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disease = metadata.get("disease", "unknown")
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is_context = metadata.get("context_enrichment", False)
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data/medical_terms_cache.json
CHANGED
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@@ -4,60 +4,60 @@
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| 4 |
"esmo"
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],
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"esmo": [
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"the european society for medical\noncology",
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"european society of medical oncology",
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-
"european society for medical oncology",
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"european society for\nmedical oncology",
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-
"the european society for medical oncology"
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-
"european\nsociety of medical oncology"
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],
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"american society of clinical\n\noncology": [
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"asco"
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| 16 |
],
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"asco": [
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"american society of clinical\n\noncology",
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-
"american society of clinical oncology",
|
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-
"american\nsociety of clinical oncology",
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"s note\n\nthis american society of clinical oncology",
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-
"md american society of clinical oncology",
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"journal of clinical oncology",
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-
"inc"
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],
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"italian association of medical oncology": [
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"aiom"
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],
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"aiom": [
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-
"italian association
|
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-
"italian association
|
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],
|
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"national comprehensive cancer network": [
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"nccn"
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],
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"nccn": [
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"national comprehensive cancer network",
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-
"
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-
"
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],
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"non-small cell lung cancer": [
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"nsclc"
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],
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"nsclc": [
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-
"e-mutant advanced non-small cell lung cancer",
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-
"advanced non-small cell lung cancer",
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-
"robotic lobectomy for non-small cell lung cancer",
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"non-small-cell lung cancer",
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"small cell lung cancer",
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-
"mutant advanced non-small cell lung cancer",
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-
"advanced non-small-cell lung cancer",
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"small-cell\nlung cancer",
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-
"small
|
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-
"iii non-small-cell lung cancer",
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-
"stage iii non small cell lung cancer",
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"lung cancer",
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"non-small cell lung cancer",
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"cancer",
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"small cell\nlung cancer",
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-
"
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],
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"american\nsociety of clinical oncology": [
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"asco"
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@@ -76,19 +76,19 @@
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],
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"glides": [
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"guidelines into decision support",
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-
"using the guidelines into decision
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-
"using the guidelines into decision
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],
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"for all the newly\neuropean medicines agency": [
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"ema"
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],
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"ema": [
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-
"european medicines agency",
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-
"and the european medicines agency",
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-
"and the european medicines\nagency",
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"for all the newly\neuropean medicines agency",
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"not european medicines agency",
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-
"for all the newly european medicines agency"
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],
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"evaluates treatments with curative intent": [
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"such\nas adjuvant chemotherapy",
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@@ -131,10 +131,10 @@
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"bsc"
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],
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"bsc": [
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-
"or best supportive\ncare",
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-
"leads to\nincreased dfs versus best supportive care",
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"or best supportive care",
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-
"
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],
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"author affiliations\nand support\n\ninformation": [
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"if\n\napplicable"
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@@ -152,17 +152,17 @@
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"rcts"
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],
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"rcts": [
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"clinical trials",
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-
"two randomized control trials"
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-
"controlled trials"
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],
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"the primary end point was disease-free\nsurvival": [
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"dfs"
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],
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"dfs": [
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-
"the primary end point was disease-free survival",
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"disease-free survival",
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-
"the primary end point was disease-free\nsurvival"
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],
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"joint cancer care ontario": [
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"cco"
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@@ -177,75 +177,75 @@
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"inst"
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],
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"inst": [
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"crispr\ntherapeutics",
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-
"
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-
"
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-
"anheart therapeutics",
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-
"inc",
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-
"regeneron",
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"bms",
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"bristol-myers squibb",
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"lilly",
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"oric pharmaceuticals",
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-
"elevation oncology",
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-
"amgen",
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-
"janssen oncology",
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-
"verastem",
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-
"medimmune",
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"black diamond therapeutics",
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-
"
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"msd",
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"guardant health",
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-
"
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-
"
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-
"
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-
"
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-
"
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"pfizer",
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-
"
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-
"
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"pharmamar",
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-
"
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-
"
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-
"
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-
"dohme",
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-
"crispr therapeutics",
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"summit therapeutics",
|
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-
"
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-
"
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-
"
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-
"
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-
"
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"takeda",
|
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-
"
|
| 221 |
-
"cullinan oncology",
|
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"abbvie",
|
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-
"bristol myers\nsquibb",
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"dizal\npharma",
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"puma biotechnology",
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-
"
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-
"
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"vivace therapeutics",
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-
"
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-
"
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-
"merck serono",
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-
"oncomed",
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-
"astrazeneca",
|
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-
"exelixis",
|
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"bayer",
|
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-
"dizal pharma",
|
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-
"inhibrx",
|
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-
"calithera biosciences",
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"polaris",
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-
"arcus biosciences",
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-
"astrazeneca canada",
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| 242 |
-
"black diamond\ntherapeutics",
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"boehringer ingelheim",
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-
"
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-
"
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-
"
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-
"
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-
"
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],
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"pfizer": [
|
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"inst"
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@@ -254,8 +254,8 @@
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"inst"
|
| 255 |
],
|
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"bristol-myers squibb": [
|
| 257 |
-
"
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| 258 |
-
"
|
| 259 |
],
|
| 260 |
"medimmune": [
|
| 261 |
"inst"
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@@ -304,18 +304,18 @@
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| 304 |
"continued"
|
| 305 |
],
|
| 306 |
"continued": [
|
| 307 |
-
"
|
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"the bottom line",
|
| 309 |
-
"
|
| 310 |
],
|
| 311 |
"salvage stereotactic body radiation therapy": [
|
| 312 |
"sbrt"
|
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],
|
| 314 |
"sbrt": [
|
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"salvage stereotactic body radiation therapy",
|
| 316 |
-
"fdg-pet and stereotactic body radiotherapy",
|
| 317 |
"sabr or stereotactic body radiotherapy",
|
| 318 |
-
"stereotactic body radiotherapy"
|
| 319 |
],
|
| 320 |
"oncomed": [
|
| 321 |
"inst"
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@@ -330,35 +330,35 @@
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"cap"
|
| 331 |
],
|
| 332 |
"cap": [
|
| 333 |
-
"
|
| 334 |
-
"
|
| 335 |
],
|
| 336 |
"association\nfor molecular pathology": [
|
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"amp"
|
| 338 |
],
|
| 339 |
"amp": [
|
| 340 |
-
"association
|
| 341 |
-
"association
|
| 342 |
],
|
| 343 |
"and anaplastic lymphoma kinase": [
|
| 344 |
"alk"
|
| 345 |
],
|
| 346 |
"alk": [
|
| 347 |
-
"phoma kinase",
|
| 348 |
-
"and anaplastic lymphoma kinase",
|
| 349 |
"crizotinib-pretreated anaplastic lymphoma kinase",
|
| 350 |
-
"positive anaplastic lymphoma kinase"
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| 351 |
],
|
| 352 |
"immunohistochemistry": [
|
| 353 |
"ihc"
|
| 354 |
],
|
| 355 |
"ihc": [
|
| 356 |
-
"
|
| 357 |
-
"immunohistochemistry"
|
| 358 |
],
|
| 359 |
"merck": [
|
| 360 |
-
"
|
| 361 |
-
"
|
| 362 |
],
|
| 363 |
"glaxosmithkline": [
|
| 364 |
"gsk",
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|
@@ -371,8 +371,8 @@
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| 371 |
"inst"
|
| 372 |
],
|
| 373 |
"bristol myers\nsquibb": [
|
| 374 |
-
"
|
| 375 |
-
"
|
| 376 |
],
|
| 377 |
"polaris": [
|
| 378 |
"inst"
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@@ -411,8 +411,8 @@
|
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| 411 |
"icis"
|
| 412 |
],
|
| 413 |
"icis": [
|
| 414 |
-
"immune checkpoint inhibitors",
|
| 415 |
-
"
|
| 416 |
],
|
| 417 |
"american society of clinical oncology": [
|
| 418 |
"asco"
|
|
@@ -433,13 +433,13 @@
|
|
| 433 |
"inst"
|
| 434 |
],
|
| 435 |
"bms": [
|
| 436 |
-
"bristol
|
| 437 |
"inst",
|
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|
| 438 |
"bristol myers\nsquibb",
|
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|
| 439 |
"celgene",
|
| 440 |
-
"bristol\nmyers squibb"
|
| 441 |
-
"bristol myers squibb",
|
| 442 |
-
"bristol-myers\nsquibb"
|
| 443 |
],
|
| 444 |
"trizell": [
|
| 445 |
"inst"
|
|
@@ -457,27 +457,27 @@
|
|
| 457 |
"rct"
|
| 458 |
],
|
| 459 |
"rct": [
|
| 460 |
-
"
|
| 461 |
"phase iib randomised controlled trial",
|
| 462 |
-
"phase iii randomised clinical trial",
|
| 463 |
"a phase iii randomised clinical trial",
|
| 464 |
-
"phase
|
|
|
|
| 465 |
],
|
| 466 |
"the primary end point of progression-free survival": [
|
| 467 |
"pfs"
|
| 468 |
],
|
| 469 |
"pfs": [
|
| 470 |
-
"the median progression-free\nsurvival",
|
| 471 |
-
"progression-free survival",
|
| 472 |
-
"and\nprogression-free survival",
|
| 473 |
-
"the median progression-free survival",
|
| 474 |
"and progression-free survival",
|
| 475 |
-
"
|
| 476 |
"quality of life and progression-free survival",
|
| 477 |
-
"
|
| 478 |
-
"the primary end point of progression-free survival",
|
| 479 |
"reported improved\nprogression-free survival",
|
| 480 |
-
"
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| 481 |
],
|
| 482 |
"adverse events": [
|
| 483 |
"aes",
|
|
@@ -485,8 +485,8 @@
|
|
| 485 |
],
|
| 486 |
"aes": [
|
| 487 |
"mainly altered lipid levels",
|
| 488 |
-
"adverse
|
| 489 |
-
"adverse
|
| 490 |
],
|
| 491 |
"and consolidation": [
|
| 492 |
"for unresectable stage iii nsclc"
|
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@@ -498,13 +498,13 @@
|
|
| 498 |
"osimertinib"
|
| 499 |
],
|
| 500 |
"osimertinib": [
|
| 501 |
-
"treatment is now an
|
| 502 |
"osi",
|
| 503 |
-
"treatment is now an
|
| 504 |
],
|
| 505 |
"inc": [
|
| 506 |
-
"
|
| 507 |
-
"
|
| 508 |
],
|
| 509 |
"small cell\nlung cancer": [
|
| 510 |
"nsclc"
|
|
@@ -519,8 +519,8 @@
|
|
| 519 |
"vegf"
|
| 520 |
],
|
| 521 |
"vegf": [
|
| 522 |
-
"and vascular
|
| 523 |
-
"and vascular
|
| 524 |
],
|
| 525 |
"though rates of\nimmune-related aes": [
|
| 526 |
"iraes"
|
|
@@ -530,15 +530,15 @@
|
|
| 530 |
"though rates of immune-related aes"
|
| 531 |
],
|
| 532 |
"bristol myers squibb": [
|
| 533 |
-
"
|
| 534 |
-
"
|
| 535 |
],
|
| 536 |
"palobiofarma": [
|
| 537 |
"inst"
|
| 538 |
],
|
| 539 |
"dohme": [
|
| 540 |
-
"
|
| 541 |
-
"
|
| 542 |
],
|
| 543 |
"mirati therapeutics": [
|
| 544 |
"inst"
|
|
@@ -565,8 +565,8 @@
|
|
| 565 |
"inst"
|
| 566 |
],
|
| 567 |
"gsk": [
|
| 568 |
-
"
|
| 569 |
-
"
|
| 570 |
],
|
| 571 |
"regeneron": [
|
| 572 |
"inst"
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@@ -624,26 +624,26 @@
|
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"health research methods"
|
| 625 |
],
|
| 626 |
"health research methods": [
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| 627 |
-
"asco practice guidelines staff",
|
| 628 |
-
"va asco practice guideline staff",
|
| 629 |
"asco practice guideline staff",
|
| 630 |
-
"
|
|
|
|
| 631 |
],
|
| 632 |
"in tyrosine kinase inhibitor": [
|
| 633 |
"tki"
|
| 634 |
],
|
| 635 |
"tki": [
|
| 636 |
-
"
|
| 637 |
-
"tyrosine kinase inhibitor"
|
| 638 |
],
|
| 639 |
"reuss et al\n\n\n\nrate": [
|
| 640 |
"orr"
|
| 641 |
],
|
| 642 |
"orr": [
|
|
|
|
| 643 |
"which had an overall response rate",
|
| 644 |
-
"reuss et al\n\n\n\nrate",
|
| 645 |
"- objective response rate",
|
| 646 |
-
"
|
| 647 |
],
|
| 648 |
"disease control rate": [
|
| 649 |
"dcr"
|
|
@@ -661,11 +661,11 @@
|
|
| 661 |
"dor"
|
| 662 |
],
|
| 663 |
"dor": [
|
|
|
|
|
|
|
| 664 |
"the median\nduration of response",
|
| 665 |
"with a median duration of response",
|
| 666 |
-
"with a median duration of\nresponse"
|
| 667 |
-
"the median duration of response",
|
| 668 |
-
"- duration of response"
|
| 669 |
],
|
| 670 |
"the most common treatment-emergent adverse events": [
|
| 671 |
"teaes"
|
|
@@ -692,8 +692,8 @@
|
|
| 692 |
"inst"
|
| 693 |
],
|
| 694 |
"msd": [
|
| 695 |
-
"
|
| 696 |
-
"
|
| 697 |
],
|
| 698 |
"lilly": [
|
| 699 |
"inst"
|
|
@@ -717,8 +717,8 @@
|
|
| 717 |
"cancer care ontario"
|
| 718 |
],
|
| 719 |
"cancer care ontario": [
|
| 720 |
-
"asco
|
| 721 |
-
"
|
| 722 |
],
|
| 723 |
"the median progression-free\nsurvival": [
|
| 724 |
"pfs"
|
|
@@ -734,8 +734,8 @@
|
|
| 734 |
],
|
| 735 |
"durvalumab": [
|
| 736 |
"if ps improves\n\nv\n\nconsolidation immunotherapy",
|
| 737 |
-
"
|
| 738 |
-
"consolidation immunotherapy"
|
| 739 |
],
|
| 740 |
"if ps improves\n\nv\n\nconsolidation immunotherapy": [
|
| 741 |
"durvalumab"
|
|
@@ -750,16 +750,16 @@
|
|
| 750 |
"bite"
|
| 751 |
],
|
| 752 |
"bite": [
|
| 753 |
-
"a bispecific t-cell
|
| 754 |
-
"a bispecific t-cell
|
| 755 |
],
|
| 756 |
"the most\ncommon ae was cytokine release syndrome": [
|
| 757 |
"crs"
|
| 758 |
],
|
| 759 |
"crs": [
|
|
|
|
| 760 |
"the most\ncommon ae was cytokine release syndrome",
|
| 761 |
-
"cytokine release syndrome"
|
| 762 |
-
"the most common ae was cytokine release syndrome"
|
| 763 |
],
|
| 764 |
"asco-ontario health": [
|
| 765 |
"cancer care ontario"
|
|
@@ -784,13 +784,13 @@
|
|
| 784 |
],
|
| 785 |
"fda": [
|
| 786 |
"or food and drug administration",
|
| 787 |
-
"the food and drug administration",
|
| 788 |
-
"entrectinib received food and\ndrug administration",
|
| 789 |
"entrectinib received food and drug administration",
|
| 790 |
-
"
|
| 791 |
-
"and the united states food and drug administration",
|
| 792 |
"food and drug administration",
|
| 793 |
-
"the
|
|
|
|
|
|
|
|
|
|
| 794 |
],
|
| 795 |
"cytokine release syndrome": [
|
| 796 |
"crs"
|
|
@@ -813,8 +813,8 @@
|
|
| 813 |
],
|
| 814 |
"nets": [
|
| 815 |
"tumors",
|
| 816 |
-
"has grouped lung and thymic neuroendocrine
|
| 817 |
-
"has grouped lung and thymic neuroendocrine
|
| 818 |
],
|
| 819 |
"small cell lung cancer": [
|
| 820 |
"nsclc",
|
|
@@ -824,15 +824,15 @@
|
|
| 824 |
"lcnec"
|
| 825 |
],
|
| 826 |
"lcnec": [
|
| 827 |
-
"and
|
| 828 |
-
"and
|
| 829 |
],
|
| 830 |
"and thymic\ncarcinoid": [
|
| 831 |
"thc"
|
| 832 |
],
|
| 833 |
"thc": [
|
| 834 |
-
"and thymic
|
| 835 |
-
"and thymic
|
| 836 |
],
|
| 837 |
"org": [
|
| 838 |
"esmo guidelines committee"
|
|
@@ -888,8 +888,8 @@
|
|
| 888 |
"ssas"
|
| 889 |
],
|
| 890 |
"ssas": [
|
| 891 |
-
"-labelled somatostatin analogues",
|
| 892 |
"medical options",
|
|
|
|
| 893 |
"what is the role of somatostatin analogues"
|
| 894 |
],
|
| 895 |
"urinary-free cortisol": [
|
|
@@ -935,19 +935,19 @@
|
|
| 935 |
"cht"
|
| 936 |
],
|
| 937 |
"cht": [
|
| 938 |
-
"chemotherapy",
|
| 939 |
"the addition of the chemotherapy",
|
| 940 |
-
"platinum-based chemotherapy",
|
| 941 |
-
"platinum-based chemo\ntherapy",
|
| 942 |
"over platinum-based doublet\nchemotherapy",
|
| 943 |
-
"
|
|
|
|
|
|
|
| 944 |
"with or without prior adjuvant chemotherapy",
|
| 945 |
-
"
|
| 946 |
-
"
|
|
|
|
| 947 |
],
|
| 948 |
"or systemic therapies": [
|
| 949 |
-
"with options
|
| 950 |
-
"with options
|
| 951 |
],
|
| 952 |
"with options\ndiscussed in these guidelines": [
|
| 953 |
"or systemic therapies"
|
|
@@ -956,8 +956,8 @@
|
|
| 956 |
"functioning syndrome"
|
| 957 |
],
|
| 958 |
"functioning syndrome": [
|
| 959 |
-
"in case of
|
| 960 |
-
"in case of
|
| 961 |
],
|
| 962 |
"and the united states food and drug administration": [
|
| 963 |
"fda"
|
|
@@ -973,9 +973,9 @@
|
|
| 973 |
"rfa"
|
| 974 |
],
|
| 975 |
"rfa": [
|
|
|
|
| 976 |
"palliative surgery\nor radiofrequency ablation",
|
| 977 |
-
"palliative surgery or radiofrequency ablation"
|
| 978 |
-
"for these patients radiofrequency ablation"
|
| 979 |
],
|
| 980 |
"or cryoablation or endobronchial treatment": [
|
| 981 |
"ebt"
|
|
@@ -987,8 +987,8 @@
|
|
| 987 |
"prrt"
|
| 988 |
],
|
| 989 |
"prrt": [
|
| 990 |
-
"peptide
|
| 991 |
-
"peptide
|
| 992 |
],
|
| 993 |
"and interferon- a": [
|
| 994 |
"ifna"
|
|
@@ -1040,8 +1040,8 @@
|
|
| 1040 |
"-fluorouracil"
|
| 1041 |
],
|
| 1042 |
"as alternative second-line": [
|
| 1043 |
-
"in case of
|
| 1044 |
-
"in case of
|
| 1045 |
],
|
| 1046 |
"in case of\nuncontrolled cs": [
|
| 1047 |
"as alternative second-line"
|
|
@@ -1074,8 +1074,8 @@
|
|
| 1074 |
"thymic net recurrences may be local"
|
| 1075 |
],
|
| 1076 |
"regional": [
|
| 1077 |
-
"intrathoracic especially
|
| 1078 |
-
"intrathoracic especially
|
| 1079 |
],
|
| 1080 |
"intrathoracic especially\npleural": [
|
| 1081 |
"regional"
|
|
@@ -1085,12 +1085,12 @@
|
|
| 1085 |
],
|
| 1086 |
"esmo-mcbs": [
|
| 1087 |
"esmo-magnitude of clinical\nbenefit",
|
| 1088 |
-
"esmo-magnitude of clinical benefit scale",
|
| 1089 |
-
"an esmo magnitude of clinical benefit scale",
|
| 1090 |
-
"esmo-magnitude of\nclinical benefit",
|
| 1091 |
"an esmo\nmagnitude of clinical benefit scale",
|
| 1092 |
"esmo-magnitude of clinical benefit",
|
| 1093 |
-
"esmomagnitude of clinical benefit scale"
|
|
|
|
|
|
|
|
|
|
| 1094 |
],
|
| 1095 |
"advanced carcinoids of the lung and thymus": [
|
| 1096 |
"luna"
|
|
@@ -1144,15 +1144,15 @@
|
|
| 1144 |
"chuv"
|
| 1145 |
],
|
| 1146 |
"chuv": [
|
| 1147 |
-
"centre hospitalier universitaire
|
| 1148 |
-
"centre hospitalier universitaire
|
| 1149 |
],
|
| 1150 |
"comparing low-dose computed tomography": [
|
| 1151 |
"ldct"
|
| 1152 |
],
|
| 1153 |
"ldct": [
|
| 1154 |
-
"
|
| 1155 |
-
"low-dose
|
| 1156 |
],
|
| 1157 |
"such as lepidic adenocarcinomas": [
|
| 1158 |
"previously named bronchioloalveolar carcinoma"
|
|
@@ -1177,11 +1177,11 @@
|
|
| 1177 |
"who"
|
| 1178 |
],
|
| 1179 |
"who": [
|
|
|
|
| 1180 |
"world health organization",
|
| 1181 |
-
"global statistics",
|
| 1182 |
"global",
|
| 1183 |
-
"
|
| 1184 |
-
"
|
| 1185 |
],
|
| 1186 |
"with its further sub-classification of": [
|
| 1187 |
"surgically resected"
|
|
@@ -1196,8 +1196,8 @@
|
|
| 1196 |
"ais"
|
| 1197 |
],
|
| 1198 |
"ais": [
|
| 1199 |
-
"the categories adenocarcinoma in situ",
|
| 1200 |
"proposed that ais be classified as tis",
|
|
|
|
| 1201 |
"proposed\nthat ais be classified as tis"
|
| 1202 |
],
|
| 1203 |
"minimally invasive adenocarcinoma": [
|
|
@@ -1229,18 +1229,18 @@
|
|
| 1229 |
"uicc"
|
| 1230 |
],
|
| 1231 |
"uicc": [
|
| 1232 |
-
"
|
| 1233 |
-
"the union for\ninternational cancer control",
|
| 1234 |
"union for international\ncancer control",
|
| 1235 |
-
"union for international cancer control"
|
|
|
|
| 1236 |
],
|
| 1237 |
"node and metastasis": [
|
| 1238 |
"tnm"
|
| 1239 |
],
|
| 1240 |
"tnm": [
|
| 1241 |
-
"
|
| 1242 |
"tumour-node-metastasis",
|
| 1243 |
-
"
|
| 1244 |
],
|
| 1245 |
"proposed\nthat ais be classified as tis": [
|
| 1246 |
"ais"
|
|
@@ -1268,9 +1268,9 @@
|
|
| 1268 |
"accp"
|
| 1269 |
],
|
| 1270 |
"accp": [
|
| 1271 |
-
"the
|
| 1272 |
"whereas the american college of chest physicians",
|
| 1273 |
-
"the
|
| 1274 |
],
|
| 1275 |
"adjuvant chemotherapy": [
|
| 1276 |
"radiotherapy"
|
|
@@ -1282,8 +1282,8 @@
|
|
| 1282 |
"vats"
|
| 1283 |
],
|
| 1284 |
"vats": [
|
| 1285 |
-
"
|
| 1286 |
-
"video-assisted
|
| 1287 |
],
|
| 1288 |
"based on the lung cancer study group": [
|
| 1289 |
"lcsg"
|
|
@@ -1347,10 +1347,10 @@
|
|
| 1347 |
"neo"
|
| 1348 |
],
|
| 1349 |
"neo": [
|
| 1350 |
-
"
|
| 1351 |
"- immunotherapy is being studied in early nsclc as",
|
| 1352 |
"immunotherapy is being studied in early nsclc as",
|
| 1353 |
-
"
|
| 1354 |
"the immune strategy in the"
|
| 1355 |
],
|
| 1356 |
"cl\n\ntreatment of locally advanced stage": [
|
|
@@ -1385,8 +1385,8 @@
|
|
| 1385 |
],
|
| 1386 |
"ests": [
|
| 1387 |
"and the european\nsociety of thoracic surgeons",
|
| 1388 |
-
"and european society of thoracic surgeons",
|
| 1389 |
-
"and
|
| 1390 |
],
|
| 1391 |
"gv scagliotti": [
|
| 1392 |
"eds"
|
|
@@ -1408,8 +1408,8 @@
|
|
| 1408 |
"pulmonology"
|
| 1409 |
],
|
| 1410 |
"pulmonology": [
|
| 1411 |
-
"respiratory oncology
|
| 1412 |
-
"respiratory oncology"
|
| 1413 |
],
|
| 1414 |
"edegem": [
|
| 1415 |
"antwerp"
|
|
@@ -1430,11 +1430,11 @@
|
|
| 1430 |
"stage iii"
|
| 1431 |
],
|
| 1432 |
"stage iii": [
|
| 1433 |
-
"
|
|
|
|
| 1434 |
"unresectable nsclc",
|
| 1435 |
"treatment of locally advanced stage",
|
| 1436 |
-
"
|
| 1437 |
-
"locally advanced nsclc"
|
| 1438 |
],
|
| 1439 |
"in paral\npractice guidelines": [
|
| 1440 |
"cpgs"
|
|
@@ -1446,9 +1446,9 @@
|
|
| 1446 |
"see panel members listed in the appendix"
|
| 1447 |
],
|
| 1448 |
"see panel members listed in the appendix": [
|
| 1449 |
-
"experts were involved in this\nconsensus process",
|
| 1450 |
"experts were involved in this consensus process",
|
| 1451 |
-
"and a general consen\nconsensus process"
|
|
|
|
| 1452 |
],
|
| 1453 |
"experts were involved in this\nconsensus process": [
|
| 1454 |
"see panel members listed in the appendix"
|
|
@@ -1466,8 +1466,8 @@
|
|
| 1466 |
"as relative value depends on personal"
|
| 1467 |
],
|
| 1468 |
"respiratory literature": [
|
| 1469 |
-
"especially on exercise
|
| 1470 |
-
"especially on exercise
|
| 1471 |
],
|
| 1472 |
"especially on exercise\ntesting": [
|
| 1473 |
"respiratory literature"
|
|
@@ -1581,13 +1581,13 @@
|
|
| 1581 |
"pbc"
|
| 1582 |
],
|
| 1583 |
"pbc": [
|
|
|
|
| 1584 |
"five cycles of tremelimumab",
|
| 1585 |
-
"five cycles of\n\ntremelimumab"
|
| 1586 |
-
"platinum-based doublet chemotherapy"
|
| 1587 |
],
|
| 1588 |
"carboplatin": [
|
| 1589 |
-
"arm
|
| 1590 |
-
"arm
|
| 1591 |
],
|
| 1592 |
"arm a": [
|
| 1593 |
"carboplatin"
|
|
@@ -1606,23 +1606,23 @@
|
|
| 1606 |
"primary endpoint"
|
| 1607 |
],
|
| 1608 |
"primary endpoint": [
|
| 1609 |
-
"
|
| 1610 |
-
"significantly improved os",
|
| 1611 |
"pbc significantly improved pfs",
|
| 1612 |
"level",
|
| 1613 |
-
"
|
|
|
|
| 1614 |
],
|
| 1615 |
"besides immune checkpoint\n\ninhibitor": [
|
| 1616 |
"ici"
|
| 1617 |
],
|
| 1618 |
"ici": [
|
| 1619 |
-
"besides immune checkpoint inhibitor",
|
| 1620 |
"besides immune checkpoint\n\ninhibitor",
|
| 1621 |
-
"and have no prior immune checkpoint inhibitor"
|
|
|
|
| 1622 |
],
|
| 1623 |
"esmo-magnitude of clinical benefit scale": [
|
| 1624 |
-
"mcbs",
|
| 1625 |
-
"
|
| 1626 |
],
|
| 1627 |
"mcbs": [
|
| 1628 |
"esmo-magnitude of clinical benefit scale"
|
|
@@ -1652,8 +1652,8 @@
|
|
| 1652 |
"ttfields"
|
| 1653 |
],
|
| 1654 |
"ttfields": [
|
| 1655 |
-
"tumour treating
|
| 1656 |
-
"tumour treating
|
| 1657 |
],
|
| 1658 |
"significantly improved os": [
|
| 1659 |
"primary endpoint"
|
|
@@ -1662,14 +1662,14 @@
|
|
| 1662 |
"esmo guidelines staff"
|
| 1663 |
],
|
| 1664 |
"esmo guidelines staff": [
|
|
|
|
| 1665 |
"ioanna ntai and claire bramley",
|
| 1666 |
"jennifer lamarre and guy atchison",
|
| 1667 |
-
"jennifer\nlamarre and guy atchison",
|
| 1668 |
"valerie laforest"
|
| 1669 |
],
|
| 1670 |
"valerie laforest": [
|
| 1671 |
-
"esmo
|
| 1672 |
-
"esmo
|
| 1673 |
],
|
| 1674 |
"esmo\nguidelines staff": [
|
| 1675 |
"valerie laforest"
|
|
@@ -1678,11 +1678,11 @@
|
|
| 1678 |
"esmo scientific affairs staff"
|
| 1679 |
],
|
| 1680 |
"esmo scientific affairs staff": [
|
| 1681 |
-
"nicola
|
| 1682 |
-
"nicola latino and\nfrancesca chiovaro",
|
| 1683 |
-
"nicola latino",
|
| 1684 |
"nicola\nlatino and francesca chiovaro",
|
| 1685 |
-
"nicola\
|
|
|
|
|
|
|
| 1686 |
],
|
| 1687 |
"bristol\nmyers squibb": [
|
| 1688 |
"bms"
|
|
@@ -1700,8 +1700,8 @@
|
|
| 1700 |
"ipsos"
|
| 1701 |
],
|
| 1702 |
"ipsos": [
|
| 1703 |
-
"
|
| 1704 |
-
"
|
| 1705 |
],
|
| 1706 |
"esmo clinical practice guideline": [
|
| 1707 |
"cpg"
|
|
@@ -1719,9 +1719,9 @@
|
|
| 1719 |
"ngs"
|
| 1720 |
],
|
| 1721 |
"ngs": [
|
| 1722 |
-
"multiplex platforms",
|
| 1723 |
"by next-generation sequencing",
|
| 1724 |
-
"such as next-generation sequencing"
|
|
|
|
| 1725 |
],
|
| 1726 |
"egfr fish or immunohistochemistry": [
|
| 1727 |
"ihc"
|
|
@@ -1733,17 +1733,17 @@
|
|
| 1733 |
"ntrk"
|
| 1734 |
],
|
| 1735 |
"ntrk": [
|
| 1736 |
-
"
|
| 1737 |
-
"or neurotrophic tyrosine receptor kinase",
|
| 1738 |
"or neurotrophic tyrosine\nreceptor kinase",
|
| 1739 |
-
"
|
|
|
|
| 1740 |
],
|
| 1741 |
"detection is reliable by\nin situ hybridisation": [
|
| 1742 |
"ish"
|
| 1743 |
],
|
| 1744 |
"ish": [
|
| 1745 |
-
"detection is reliable by
|
| 1746 |
-
"detection is reliable by
|
| 1747 |
],
|
| 1748 |
"mesenchymal-epithelial transition": [
|
| 1749 |
"met"
|
|
@@ -1781,8 +1781,8 @@
|
|
| 1781 |
"fdg"
|
| 1782 |
],
|
| 1783 |
"fdg": [
|
| 1784 |
-
"
|
| 1785 |
-
"-
|
| 1786 |
],
|
| 1787 |
"union for international\ncancer control": [
|
| 1788 |
"uicc"
|
|
@@ -1811,10 +1811,10 @@
|
|
| 1811 |
"mos"
|
| 1812 |
],
|
| 1813 |
"mos": [
|
| 1814 |
-
"and median os",
|
| 1815 |
"malaysian oncological society",
|
| 1816 |
"malaysia",
|
| 1817 |
-
"the malaysian oncological society"
|
|
|
|
| 1818 |
],
|
| 1819 |
"systemic progression\n\nlocal treatment": [
|
| 1820 |
"surgery or ft"
|
|
@@ -1848,15 +1848,15 @@
|
|
| 1848 |
"japan"
|
| 1849 |
],
|
| 1850 |
"japan": [
|
| 1851 |
-
"
|
| 1852 |
-
"
|
| 1853 |
],
|
| 1854 |
"and\nalesia": [
|
| 1855 |
"asia"
|
| 1856 |
],
|
| 1857 |
"asia": [
|
| 1858 |
-
"and
|
| 1859 |
-
"and
|
| 1860 |
],
|
| 1861 |
"and continue targeted": [
|
| 1862 |
"not mandatory for decision"
|
|
@@ -1889,8 +1889,8 @@
|
|
| 1889 |
"mdor"
|
| 1890 |
],
|
| 1891 |
"mdor": [
|
| 1892 |
-
"the
|
| 1893 |
-
"the
|
| 1894 |
],
|
| 1895 |
"tropomyosin receptor tyrosine kinase": [
|
| 1896 |
"trk"
|
|
@@ -1902,9 +1902,9 @@
|
|
| 1902 |
"surgery or rt"
|
| 1903 |
],
|
| 1904 |
"surgery or rt": [
|
|
|
|
| 1905 |
"oligoprogression\n\nlocal treatment",
|
| 1906 |
"local treatment",
|
| 1907 |
-
"- local treatment",
|
| 1908 |
"disease progression\n\nlocal treatment"
|
| 1909 |
],
|
| 1910 |
"or combination therapy with a mek inhibitor": [
|
|
@@ -1932,8 +1932,8 @@
|
|
| 1932 |
"kras"
|
| 1933 |
],
|
| 1934 |
"kras": [
|
| 1935 |
-
"the
|
| 1936 |
-
"the
|
| 1937 |
],
|
| 1938 |
"data regarding the role of local ablative therapy": [
|
| 1939 |
"lat"
|
|
@@ -1972,8 +1972,8 @@
|
|
| 1972 |
"esmo scientific affairs staff"
|
| 1973 |
],
|
| 1974 |
"and dr svetlana jezdic": [
|
| 1975 |
-
"esmo\nmedical affairs advisor",
|
| 1976 |
"esmo medical affairs advisor",
|
|
|
|
| 1977 |
"esmo medical affairs staff"
|
| 1978 |
],
|
| 1979 |
"esmo\nmedical affairs advisor": [
|
|
@@ -1986,8 +1986,8 @@
|
|
| 1986 |
"atorg"
|
| 1987 |
],
|
| 1988 |
"atorg": [
|
| 1989 |
-
"asian
|
| 1990 |
-
"asian
|
| 1991 |
],
|
| 1992 |
"chinese lung\ncancer research foundation limited": [
|
| 1993 |
"clcrf"
|
|
@@ -2062,8 +2062,8 @@
|
|
| 2062 |
"asmac"
|
| 2063 |
],
|
| 2064 |
"asmac": [
|
| 2065 |
-
"s
|
| 2066 |
-
"s
|
| 2067 |
],
|
| 2068 |
"rzte": [
|
| 2069 |
"vsao"
|
|
@@ -2084,12 +2084,12 @@
|
|
| 2084 |
"cancers"
|
| 2085 |
],
|
| 2086 |
"relay": [
|
| 2087 |
-
"
|
| 2088 |
-
"cancer"
|
| 2089 |
],
|
| 2090 |
"non-small-cell lung cancer": [
|
| 2091 |
-
"
|
| 2092 |
-
"
|
| 2093 |
],
|
| 2094 |
"alesia": [
|
| 2095 |
"non-small-cell lung cancer"
|
|
@@ -2111,9 +2111,9 @@
|
|
| 2111 |
"chmp"
|
| 2112 |
],
|
| 2113 |
"chmp": [
|
| 2114 |
-
"tabrecta - summary of opinion",
|
| 2115 |
"products for human use",
|
| 2116 |
-
"retsevmo - summary of opinion"
|
|
|
|
| 2117 |
],
|
| 2118 |
"tabrecta - summary of opinion": [
|
| 2119 |
"chmp"
|
|
@@ -2150,8 +2150,8 @@
|
|
| 2150 |
],
|
| 2151 |
"jsmo": [
|
| 2152 |
"the\njapanese society of medical oncology",
|
| 2153 |
-
"
|
| 2154 |
-
"
|
| 2155 |
],
|
| 2156 |
"korea": [
|
| 2157 |
"ksmo"
|
|
@@ -2166,10 +2166,10 @@
|
|
| 2166 |
"psmo"
|
| 2167 |
],
|
| 2168 |
"psmo": [
|
| 2169 |
-
"the philippine society of medical oncology",
|
| 2170 |
"and philippine society of medical oncology",
|
| 2171 |
-
"the philippines",
|
| 2172 |
"and philippine society of medical\noncology",
|
|
|
|
|
|
|
| 2173 |
"the philippine society of\nmedical oncology"
|
| 2174 |
],
|
| 2175 |
"singapore": [
|
|
@@ -2184,15 +2184,15 @@
|
|
| 2184 |
"tos"
|
| 2185 |
],
|
| 2186 |
"tos": [
|
| 2187 |
-
"
|
| 2188 |
-
"taiwan"
|
| 2189 |
],
|
| 2190 |
"and thailand": [
|
| 2191 |
"tsco"
|
| 2192 |
],
|
| 2193 |
"tsco": [
|
| 2194 |
-
"and thailand",
|
| 2195 |
"and the\nthai society of clinical oncology",
|
|
|
|
| 2196 |
"and the thai society of clinical oncology"
|
| 2197 |
],
|
| 2198 |
"and the neurotrophic receptor tyrosine\nkinase": [
|
|
@@ -2229,8 +2229,8 @@
|
|
| 2229 |
"tmk and hrk"
|
| 2230 |
],
|
| 2231 |
"tmk and hrk": [
|
| 2232 |
-
"only two of the six
|
| 2233 |
-
"only two of the six
|
| 2234 |
],
|
| 2235 |
"performance status": [
|
| 2236 |
"ecog ps"
|
|
@@ -2266,8 +2266,8 @@
|
|
| 2266 |
"such as osimertinib"
|
| 2267 |
],
|
| 2268 |
"such as osimertinib": [
|
| 2269 |
-
"
|
| 2270 |
-
"generation
|
| 2271 |
],
|
| 2272 |
"generation tki": [
|
| 2273 |
"such as osimertinib"
|
|
@@ -2306,9 +2306,9 @@
|
|
| 2306 |
"traes"
|
| 2307 |
],
|
| 2308 |
"traes": [
|
| 2309 |
-
"treatment-related
|
| 2310 |
"what are the treatment-related adverse events",
|
| 2311 |
-
"treatment-related
|
| 2312 |
],
|
| 2313 |
"and have no prior immune checkpoint inhibitor": [
|
| 2314 |
"ici"
|
|
@@ -2326,8 +2326,8 @@
|
|
| 2326 |
"jkn"
|
| 2327 |
],
|
| 2328 |
"jkn": [
|
| 2329 |
-
"ishmo\n\nthe jaminan kesehatan nasional",
|
| 2330 |
-
"ishmo\n\
|
| 2331 |
],
|
| 2332 |
"there is no regulation of partial coverage": [
|
| 2333 |
"co-payment"
|
|
@@ -2339,8 +2339,8 @@
|
|
| 2339 |
"pap"
|
| 2340 |
],
|
| 2341 |
"pap": [
|
| 2342 |
-
"
|
| 2343 |
-
"
|
| 2344 |
],
|
| 2345 |
"mandatory national health insurance": [
|
| 2346 |
"nhi"
|
|
@@ -2368,8 +2368,8 @@
|
|
| 2368 |
"alk inhibitors"
|
| 2369 |
],
|
| 2370 |
"and atezolizumab": [
|
| 2371 |
-
"in the
|
| 2372 |
-
"in the
|
| 2373 |
],
|
| 2374 |
"in the\nsecond-line setting": [
|
| 2375 |
"and atezolizumab"
|
|
@@ -2385,8 +2385,8 @@
|
|
| 2385 |
"first-line"
|
| 2386 |
],
|
| 2387 |
"first-line": [
|
| 2388 |
-
"and the alk inhibitors ceritinib and
|
| 2389 |
-
"and the alk inhibitors ceritinib and
|
| 2390 |
],
|
| 2391 |
"german": [
|
| 2392 |
"merck"
|
|
@@ -2395,8 +2395,8 @@
|
|
| 2395 |
"torg"
|
| 2396 |
],
|
| 2397 |
"torg": [
|
| 2398 |
-
"thoracic oncology research
|
| 2399 |
-
"thoracic oncology research
|
| 2400 |
],
|
| 2401 |
"and west japan oncology group": [
|
| 2402 |
"wjog"
|
|
@@ -2405,8 +2405,8 @@
|
|
| 2405 |
"and west japan oncology group"
|
| 2406 |
],
|
| 2407 |
"product samples": [
|
| 2408 |
-
"
|
| 2409 |
-
"
|
| 2410 |
],
|
| 2411 |
"nonrenumerated": [
|
| 2412 |
"product samples"
|
|
@@ -2479,21 +2479,21 @@
|
|
| 2479 |
"mnsclc"
|
| 2480 |
],
|
| 2481 |
"mnsclc": [
|
| 2482 |
-
"
|
| 2483 |
-
"
|
| 2484 |
],
|
| 2485 |
"binimetinib in patients": [
|
| 2486 |
"pts"
|
| 2487 |
],
|
| 2488 |
"pts": [
|
| 2489 |
-
"versus docetaxel in patients",
|
| 2490 |
"patients",
|
| 2491 |
-
"therapy in patients",
|
| 2492 |
-
"mo encorafenib plus\n\nbinimetinib in patients",
|
| 2493 |
-
"p repotrectinib in patients",
|
| 2494 |
"mo encorafenib plus binimetinib in patients",
|
| 2495 |
"binimetinib in patients",
|
| 2496 |
-
"
|
|
|
|
|
|
|
|
|
|
|
|
|
| 2497 |
],
|
| 2498 |
"mutant advanced non-small cell lung cancer": [
|
| 2499 |
"nsclc"
|
|
@@ -2509,8 +2509,8 @@
|
|
| 2509 |
],
|
| 2510 |
"treatment of early stages": [
|
| 2511 |
"stages i-ii",
|
| 2512 |
-
"stages i
|
| 2513 |
-
"stages i
|
| 2514 |
],
|
| 2515 |
"stages i-iiia": [
|
| 2516 |
"treatment of early stages"
|
|
@@ -2523,8 +2523,8 @@
|
|
| 2523 |
],
|
| 2524 |
"chemotherapy": [
|
| 2525 |
"- everolimus\n - cht",
|
| 2526 |
-
"
|
| 2527 |
-
"
|
| 2528 |
],
|
| 2529 |
"the median\nwas not reached": [
|
| 2530 |
"ne-ne"
|
|
@@ -2543,8 +2543,8 @@
|
|
| 2543 |
"neo"
|
| 2544 |
],
|
| 2545 |
"or docetaxel or pemetrexed": [
|
| 2546 |
-
"only in
|
| 2547 |
-
"only in
|
| 2548 |
],
|
| 2549 |
"only in\nadenocarcinoma tumours": [
|
| 2550 |
"or docetaxel or pemetrexed"
|
|
@@ -2553,9 +2553,9 @@
|
|
| 2553 |
"port"
|
| 2554 |
],
|
| 2555 |
"port": [
|
| 2556 |
-
"
|
| 2557 |
"post-operative radiotherapy",
|
| 2558 |
-
"
|
| 2559 |
],
|
| 2560 |
"treatment of locally advanced stage": [
|
| 2561 |
"stage iii"
|
|
@@ -2594,9 +2594,9 @@
|
|
| 2594 |
"pacific"
|
| 2595 |
],
|
| 2596 |
"pacific": [
|
| 2597 |
-
"small-cell lung cancer",
|
| 2598 |
"concurrent chemoradiation therapy",
|
| 2599 |
-
"unresectable non-small-cell lung cancer"
|
|
|
|
| 2600 |
],
|
| 2601 |
"adaura": [
|
| 2602 |
"chemotherapy"
|
|
@@ -2605,8 +2605,8 @@
|
|
| 2605 |
"including stage ib"
|
| 2606 |
],
|
| 2607 |
"including stage ib": [
|
| 2608 |
-
"approval was based on all patient data",
|
| 2609 |
-
"
|
| 2610 |
],
|
| 2611 |
"on tumour cells": [
|
| 2612 |
"as per the\nema-approved indication",
|
|
@@ -2649,8 +2649,8 @@
|
|
| 2649 |
"egfrm"
|
| 2650 |
],
|
| 2651 |
"nivolumab": [
|
| 2652 |
-
"
|
| 2653 |
-
"
|
| 2654 |
],
|
| 2655 |
"nivo": [
|
| 2656 |
"nivolumab"
|
|
@@ -2659,16 +2659,16 @@
|
|
| 2659 |
"chemo"
|
| 2660 |
],
|
| 2661 |
"chemo": [
|
|
|
|
| 2662 |
"platinum-doublet chemotherapy",
|
| 2663 |
-
"platinum-doublet\nchemotherapy"
|
| 2664 |
-
"platinum-based chemotherapy"
|
| 2665 |
],
|
| 2666 |
"for\nresectable": [
|
| 2667 |
"ib-iiia"
|
| 2668 |
],
|
| 2669 |
"ib-iiia": [
|
| 2670 |
-
"for
|
| 2671 |
-
"for
|
| 2672 |
],
|
| 2673 |
"lung cancer": [
|
| 2674 |
"nsclc"
|
|
@@ -2692,8 +2692,8 @@
|
|
| 2692 |
"diques august pi i sunyer"
|
| 2693 |
],
|
| 2694 |
"department of radiation oncology": [
|
| 2695 |
-
"maastro",
|
| 2696 |
-
"maastro
|
| 2697 |
],
|
| 2698 |
"maastro clinic": [
|
| 2699 |
"department of radiation oncology"
|
|
@@ -3215,8 +3215,8 @@
|
|
| 3215 |
"rfa"
|
| 3216 |
],
|
| 3217 |
"peptide receptor radionuclide therapy": [
|
| 3218 |
-
"prrt",
|
| 3219 |
-
"
|
| 3220 |
],
|
| 3221 |
"what is the role of somatostatin analogues": [
|
| 3222 |
"ssas"
|
|
@@ -3423,8 +3423,8 @@
|
|
| 3423 |
"fda"
|
| 3424 |
],
|
| 3425 |
"the median duration of response": [
|
| 3426 |
-
"
|
| 3427 |
-
"
|
| 3428 |
],
|
| 3429 |
"deruxtecan": [
|
| 3430 |
"fda approved"
|
|
@@ -3535,13 +3535,13 @@
|
|
| 3535 |
"author"
|
| 3536 |
],
|
| 3537 |
"author": [
|
|
|
|
|
|
|
| 3538 |
"jchy",
|
|
|
|
| 3539 |
"msi",
|
| 3540 |
"tmk",
|
| 3541 |
-
"ddwl"
|
| 3542 |
-
"cew",
|
| 3543 |
-
"sak",
|
| 3544 |
-
"hrk"
|
| 3545 |
],
|
| 3546 |
"hrk": [
|
| 3547 |
"author"
|
|
@@ -3661,158 +3661,158 @@
|
|
| 3661 |
},
|
| 3662 |
"abbreviations": {
|
| 3663 |
"esmo": [
|
|
|
|
|
|
|
|
|
|
| 3664 |
"european\nsociety of medical oncology",
|
| 3665 |
"the following european society for medical oncology",
|
| 3666 |
-
"european society
|
| 3667 |
-
"european society for medical oncology",
|
| 3668 |
"living guideline\n\nthe following european society for medical oncology",
|
| 3669 |
-
"european society for medical\noncology",
|
| 3670 |
"european society for\nmedical oncology",
|
| 3671 |
-
"
|
| 3672 |
-
"the most recent european society for medical oncology"
|
| 3673 |
],
|
| 3674 |
"asco": [
|
| 3675 |
-
"american society of clinical\noncology",
|
| 3676 |
"american society of clinical\n\noncology",
|
| 3677 |
-
"american society of clinical oncology",
|
| 3678 |
-
"american\nsociety of clinical oncology",
|
| 3679 |
-
"this american society of clinical oncology",
|
| 3680 |
"journal of clinical oncology",
|
| 3681 |
-
"
|
|
|
|
|
|
|
|
|
|
|
|
|
| 3682 |
],
|
| 3683 |
"aiom": [
|
| 3684 |
-
"italian association
|
| 3685 |
"italian association of medical oncology",
|
| 3686 |
-
"
|
| 3687 |
],
|
| 3688 |
"nccn": [
|
| 3689 |
-
"
|
| 3690 |
-
"
|
| 3691 |
],
|
| 3692 |
"glides": [
|
|
|
|
| 3693 |
"guidelines into decision\nsupport",
|
| 3694 |
-
"guidelines into decision support"
|
| 3695 |
-
"ecision support"
|
| 3696 |
],
|
| 3697 |
"glc": [
|
| 3698 |
"guidelines committee"
|
| 3699 |
],
|
| 3700 |
"mcbs": [
|
| 3701 |
-
"magnitude of clinical benefit
|
| 3702 |
"magnitude\nof clinical benefit score",
|
| 3703 |
-
"magnitude of clinical benefit
|
| 3704 |
],
|
| 3705 |
"ema": [
|
| 3706 |
"european medicines\nagency",
|
| 3707 |
"european medicines agency"
|
| 3708 |
],
|
| 3709 |
"sclc": [
|
| 3710 |
-
"clinical practice guidelines on small cell lung cancer",
|
| 3711 |
-
"small cell lung cancer",
|
| 3712 |
"what is the treatment algorithm for patients with small cell lung cancer",
|
|
|
|
| 3713 |
"clinical practice guidelines on small cell lung\ncancer",
|
|
|
|
| 3714 |
"what are the recommended treatment options for patients with relapsed small cell lung cancer"
|
| 3715 |
],
|
| 3716 |
"cco": [
|
| 3717 |
"cancer care ontario"
|
| 3718 |
],
|
| 3719 |
"astro": [
|
| 3720 |
-
"executive summary of an american society for
|
| 3721 |
-
"executive summary of an american society for
|
| 3722 |
],
|
| 3723 |
"inst": [
|
| 3724 |
-
"
|
| 3725 |
-
"
|
| 3726 |
-
"regeneron",
|
| 3727 |
-
"lilly",
|
| 3728 |
-
"heart therapeutics",
|
| 3729 |
-
"elevation oncology",
|
| 3730 |
-
"amgen",
|
| 3731 |
-
"janssen oncology",
|
| 3732 |
-
"verastem",
|
| 3733 |
-
"myers squibb",
|
| 3734 |
-
"black diamond therapeutics",
|
| 3735 |
-
"zeneca",
|
| 3736 |
-
"janssen",
|
| 3737 |
-
"guardant health",
|
| 3738 |
-
"palobiofarma",
|
| 3739 |
-
"constellation pharmaceuticals",
|
| 3740 |
-
"immune",
|
| 3741 |
"blueprint medicines",
|
| 3742 |
-
"
|
| 3743 |
-
"
|
| 3744 |
-
"therapeutics",
|
| 3745 |
-
"mirati therapeutics",
|
| 3746 |
"revolution medicines",
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 3747 |
"dohme",
|
| 3748 |
-
"
|
| 3749 |
"harpoon therapeutics",
|
| 3750 |
-
"
|
|
|
|
| 3751 |
"kline canada",
|
| 3752 |
-
"
|
| 3753 |
-
"
|
| 3754 |
-
"
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 3755 |
"takeda",
|
| 3756 |
-
"astra zeneca",
|
| 3757 |
-
"genomics",
|
| 3758 |
-
"cullinan oncology",
|
| 3759 |
-
"zeneca canada",
|
| 3760 |
-
"bristol myers\nsquibb",
|
| 3761 |
"dizal\npharma",
|
|
|
|
|
|
|
|
|
|
|
|
|
| 3762 |
"puma biotechnology",
|
| 3763 |
-
"
|
| 3764 |
-
"
|
| 3765 |
"vivace therapeutics",
|
| 3766 |
-
"
|
| 3767 |
-
"
|
| 3768 |
-
"merck serono",
|
| 3769 |
-
"exelixis",
|
| 3770 |
"bayer",
|
| 3771 |
-
"dizal pharma",
|
| 3772 |
-
"inhibrx",
|
| 3773 |
-
"calithera biosciences",
|
| 3774 |
-
"polaris",
|
| 3775 |
-
"arcus biosciences",
|
| 3776 |
-
"black diamond\ntherapeutics",
|
| 3777 |
-
"boehringer ingelheim",
|
| 3778 |
-
"sutro biopharma",
|
| 3779 |
-
"bristol myers squibb",
|
| 3780 |
-
"forward",
|
| 3781 |
-
"roche",
|
| 3782 |
"pharmaceuticals",
|
| 3783 |
-
"
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 3784 |
],
|
| 3785 |
"ct": [
|
| 3786 |
-
"the use of computed tomography",
|
| 3787 |
-
"computed tomography",
|
| 3788 |
"the use of\ncomputed tomography",
|
| 3789 |
-
"clinicians should use a diagnostic chest computed tomography"
|
|
|
|
|
|
|
| 3790 |
],
|
| 3791 |
"mri": [
|
| 3792 |
"what is the role of brain magnetic resonance imaging"
|
| 3793 |
],
|
| 3794 |
"sbrt": [
|
| 3795 |
-
"
|
| 3796 |
-
"stereotactic body
|
| 3797 |
],
|
| 3798 |
"cap": [
|
| 3799 |
"pathologists",
|
| 3800 |
"college of american pathologists"
|
| 3801 |
],
|
| 3802 |
"iaslc": [
|
|
|
|
|
|
|
|
|
|
|
|
|
| 3803 |
"pathology committee chair for international association for the study of lung cancer",
|
| 3804 |
"study of lung cancer",
|
| 3805 |
-
"the\ninternational association for the study of lung cancer",
|
| 3806 |
"pathology committee chair\nfor international association for the study of lung cancer",
|
| 3807 |
-
"international association for the\nstudy of lung cancer",
|
| 3808 |
"international association for the study of lung cancer",
|
| 3809 |
-
"international association for the\
|
| 3810 |
-
"the international association for the study of lung cancer",
|
| 3811 |
-
"international association for\nthe study of lung cancer"
|
| 3812 |
],
|
| 3813 |
"amp": [
|
| 3814 |
-
"association
|
| 3815 |
-
"association
|
| 3816 |
],
|
| 3817 |
"ihc": [
|
| 3818 |
"immunohistochemistry"
|
|
@@ -3824,11 +3824,11 @@
|
|
| 3824 |
"although the results from the mesothelioma and radical surgery"
|
| 3825 |
],
|
| 3826 |
"os": [
|
| 3827 |
-
"the median\noverall survival",
|
| 3828 |
-
"median overall survival",
|
| 3829 |
"overall survival",
|
| 3830 |
"the median overall survival",
|
| 3831 |
-
"the only data published thus far pertain to the dual primary end points of overall survival"
|
|
|
|
|
|
|
| 3832 |
],
|
| 3833 |
"elsevier": [
|
| 3834 |
"clinical lung cancer"
|
|
@@ -3837,27 +3837,27 @@
|
|
| 3837 |
"one randomized controlled trial"
|
| 3838 |
],
|
| 3839 |
"ps": [
|
| 3840 |
-
"eastern cooperative oncology group performance
|
| 3841 |
-
"eastern cooperative oncology group performance
|
| 3842 |
],
|
| 3843 |
"orr": [
|
| 3844 |
"is result in a lower overall response\nrate",
|
| 3845 |
-
"objective response rate",
|
| 3846 |
"is result in a lower overall response rate",
|
|
|
|
| 3847 |
"reuss et al\n\n\n\nrate"
|
| 3848 |
],
|
| 3849 |
"pci": [
|
| 3850 |
-
"prophylactic cranial irradiation",
|
| 3851 |
-
"
|
| 3852 |
],
|
| 3853 |
"fda": [
|
| 3854 |
-
"entrectinib received food and\ndrug administration",
|
| 3855 |
"entrectinib received food and drug administration",
|
| 3856 |
-
"
|
| 3857 |
-
"food and drug administration",
|
| 3858 |
"osimertinib is approved by both the united states food and\ndrug administration",
|
| 3859 |
-
"
|
| 3860 |
-
"
|
|
|
|
|
|
|
| 3861 |
],
|
| 3862 |
"crs": [
|
| 3863 |
"cytokine release syndrome"
|
|
@@ -3866,44 +3866,44 @@
|
|
| 3866 |
"department of surgical sciences"
|
| 3867 |
],
|
| 3868 |
"who": [
|
| 3869 |
-
"the
|
| 3870 |
"world health organization",
|
| 3871 |
-
"global statistics",
|
| 3872 |
"global",
|
| 3873 |
-
"the
|
|
|
|
| 3874 |
],
|
| 3875 |
"lc": [
|
| 3876 |
-
"these
|
| 3877 |
-
"these
|
| 3878 |
],
|
| 3879 |
"seer": [
|
| 3880 |
-
"
|
| 3881 |
-
"end results"
|
| 3882 |
],
|
| 3883 |
"uicc": [
|
|
|
|
| 3884 |
"edition of the union for\ninternational cancer control",
|
|
|
|
| 3885 |
"union for international cancer control",
|
| 3886 |
-
"union for international\ncancer control"
|
| 3887 |
-
"edition of the union for international cancer control",
|
| 3888 |
-
"union for\ninternational cancer control"
|
| 3889 |
],
|
| 3890 |
"gep": [
|
| 3891 |
-
"based on
|
| 3892 |
-
"based on
|
| 3893 |
],
|
| 3894 |
"pth": [
|
| 3895 |
"annals of oncology\n\n\n\nparathyroid hormone"
|
| 3896 |
],
|
| 3897 |
"rfa": [
|
|
|
|
| 3898 |
"palliative surgery\nor radiofrequency ablation",
|
| 3899 |
-
"palliative surgery or radiofrequency ablation"
|
| 3900 |
-
"for these patients radiofrequency ablation"
|
| 3901 |
],
|
| 3902 |
"recist": [
|
| 3903 |
"cs with response evaluation criteria in solid tumours",
|
| 3904 |
-
"
|
| 3905 |
"measurements and response assessment should follow response evaluation criteria in solid tumours",
|
| 3906 |
-
"
|
| 3907 |
],
|
| 3908 |
"gemox": [
|
| 3909 |
"oxaliplatin combined with gemcitabine"
|
|
@@ -3912,8 +3912,8 @@
|
|
| 3912 |
"lanreotide autogel"
|
| 3913 |
],
|
| 3914 |
"chuv": [
|
| 3915 |
-
"centre hospitalier universitaire
|
| 3916 |
-
"centre hospitalier universitaire
|
| 3917 |
],
|
| 3918 |
"nlst": [
|
| 3919 |
"the much larger national lung cancer screening trial",
|
|
@@ -3964,12 +3964,12 @@
|
|
| 3964 |
"the thoracic surgery scoring\nsystem"
|
| 3965 |
],
|
| 3966 |
"pulmonology": [
|
| 3967 |
-
"respiratory oncology
|
| 3968 |
-
"respiratory oncology"
|
| 3969 |
],
|
| 3970 |
"acs": [
|
| 3971 |
-
"lung cancer screening guidelines published by the
|
| 3972 |
-
"lung cancer screening guidelines published by the
|
| 3973 |
],
|
| 3974 |
"ialt": [
|
| 3975 |
"some trials"
|
|
@@ -3978,11 +3978,11 @@
|
|
| 3978 |
"adjuvant navelbine international trialist association"
|
| 3979 |
],
|
| 3980 |
"sabr": [
|
|
|
|
| 3981 |
"what are the indications and recommendations for salvage surgery after stereotactic ablative radiotherapy",
|
| 3982 |
-
"radiographic changes after lung stereotactic ablative radiotherapy",
|
| 3983 |
"what are the outcomes comparing stereotactic ablative radiotherapy",
|
| 3984 |
-
"radiographic changes after lung stereotactic
|
| 3985 |
-
"
|
| 3986 |
],
|
| 3987 |
"vumc": [
|
| 3988 |
"vrije\nuniversity medical centre",
|
|
@@ -3993,36 +3993,36 @@
|
|
| 3993 |
"bemeneed"
|
| 3994 |
],
|
| 3995 |
"bms": [
|
|
|
|
| 3996 |
"myers\nsquibb",
|
|
|
|
| 3997 |
"bristol myers\nsquibb",
|
| 3998 |
-
"bristol\nmyers squibb"
|
| 3999 |
-
"bristol myers squibb",
|
| 4000 |
-
"myers squibb"
|
| 4001 |
],
|
| 4002 |
"msd": [
|
| 4003 |
"dohme"
|
| 4004 |
],
|
| 4005 |
"eortc": [
|
| 4006 |
-
"chair of the european organisation for research and treatment of cancer",
|
| 4007 |
"chair of the european\norganisation for research and treatment of cancer",
|
| 4008 |
-
"european
|
| 4009 |
"treatment of cancer",
|
| 4010 |
-
"european
|
|
|
|
| 4011 |
],
|
| 4012 |
"cpg": [
|
| 4013 |
"clinical practice guideline"
|
| 4014 |
],
|
| 4015 |
"escat": [
|
| 4016 |
"scale for clinical actionability of\nmolecular targets",
|
| 4017 |
-
"
|
| 4018 |
-
"targets"
|
| 4019 |
],
|
| 4020 |
"alk": [
|
| 4021 |
"positive anaplastic lymphoma kinase"
|
| 4022 |
],
|
| 4023 |
"ish": [
|
| 4024 |
-
"detection is reliable by
|
| 4025 |
-
"detection is reliable by
|
| 4026 |
],
|
| 4027 |
"cns": [
|
| 4028 |
"imaging of the central nervous system"
|
|
@@ -4041,8 +4041,8 @@
|
|
| 4041 |
"interstitial lung disease"
|
| 4042 |
],
|
| 4043 |
"kras": [
|
| 4044 |
-
"the
|
| 4045 |
-
"the
|
| 4046 |
],
|
| 4047 |
"lat": [
|
| 4048 |
"data regarding the role of local ablative therapy"
|
|
@@ -4058,17 +4058,17 @@
|
|
| 4058 |
"lung cancer group and past secretary and current\nchair of the nederlandse vereniging van artsen voor longziekten en tuberculose"
|
| 4059 |
],
|
| 4060 |
"atorg": [
|
| 4061 |
-
"asian
|
| 4062 |
-
"asian
|
| 4063 |
],
|
| 4064 |
"clcrf": [
|
| 4065 |
"chinese lung\ncancer research foundation limited",
|
| 4066 |
"chinese lung cancer research foundation limited"
|
| 4067 |
],
|
| 4068 |
"csco": [
|
| 4069 |
-
"chinese\nsociety of clinical oncology",
|
| 4070 |
"chinese society of clinical oncology",
|
| 4071 |
-
"china"
|
|
|
|
| 4072 |
],
|
| 4073 |
"hkcf": [
|
| 4074 |
"hong kong cancer fund"
|
|
@@ -4087,13 +4087,13 @@
|
|
| 4087 |
"research to practice"
|
| 4088 |
],
|
| 4089 |
"samo": [
|
| 4090 |
-
"president of swiss
|
| 4091 |
-
"president of swiss
|
| 4092 |
],
|
| 4093 |
"sakk": [
|
| 4094 |
"research",
|
| 4095 |
-
"president of lung group for swiss group for clinical cancer
|
| 4096 |
-
"president of lung group for swiss group for clinical cancer
|
| 4097 |
],
|
| 4098 |
"etop": [
|
| 4099 |
"european thoracic oncology platform"
|
|
@@ -4102,8 +4102,8 @@
|
|
| 4102 |
"international breast cancer study group"
|
| 4103 |
],
|
| 4104 |
"aacr": [
|
| 4105 |
-
"partners member
|
| 4106 |
-
"partners member
|
| 4107 |
],
|
| 4108 |
"asmac": [
|
| 4109 |
"clinique"
|
|
@@ -4113,20 +4113,20 @@
|
|
| 4113 |
],
|
| 4114 |
"chmp": [
|
| 4115 |
"summary of opinion",
|
| 4116 |
-
"
|
| 4117 |
-
"products for human use"
|
| 4118 |
],
|
| 4119 |
"paga": [
|
| 4120 |
"asian adapted"
|
| 4121 |
],
|
| 4122 |
"ishmo": [
|
| 4123 |
-
"indonesia",
|
| 4124 |
"indonesian society\nof hematology and medical oncology",
|
| 4125 |
-
"indonesian society of hematology and medical oncology"
|
|
|
|
| 4126 |
],
|
| 4127 |
"jsmo": [
|
| 4128 |
-
"
|
| 4129 |
-
"
|
| 4130 |
],
|
| 4131 |
"ksmo": [
|
| 4132 |
"korea",
|
|
@@ -4137,9 +4137,9 @@
|
|
| 4137 |
"malaysia"
|
| 4138 |
],
|
| 4139 |
"psmo": [
|
| 4140 |
-
"philippine society of\nmedical oncology",
|
| 4141 |
-
"philippine society of medical\noncology",
|
| 4142 |
"philippines",
|
|
|
|
|
|
|
| 4143 |
"philippine society of medical oncology"
|
| 4144 |
],
|
| 4145 |
"sso": [
|
|
@@ -4148,8 +4148,8 @@
|
|
| 4148 |
"singapore"
|
| 4149 |
],
|
| 4150 |
"tos": [
|
| 4151 |
-
"taiwan
|
| 4152 |
-
"taiwan"
|
| 4153 |
],
|
| 4154 |
"tsco": [
|
| 4155 |
"thai society of clinical oncology",
|
|
@@ -4163,31 +4163,31 @@
|
|
| 4163 |
"national medical products\nadministration"
|
| 4164 |
],
|
| 4165 |
"nmpa": [
|
| 4166 |
-
"chinese national
|
| 4167 |
-
"chinese national
|
| 4168 |
],
|
| 4169 |
"jkn": [
|
| 4170 |
"the jaminan kesehatan nasional"
|
| 4171 |
],
|
| 4172 |
"fornas": [
|
| 4173 |
-
"na\ntional drug formulary",
|
| 4174 |
"national standard of medication list",
|
| 4175 |
"national standard of\nmedication list",
|
| 4176 |
-
"national drug formulary"
|
|
|
|
| 4177 |
],
|
| 4178 |
"pap": [
|
| 4179 |
"open\n\n\n\nprogram"
|
| 4180 |
],
|
| 4181 |
"pdma": [
|
| 4182 |
-
"it may take
|
| 4183 |
-
"it may take
|
| 4184 |
],
|
| 4185 |
"nhi": [
|
| 4186 |
"national health insurance"
|
| 4187 |
],
|
| 4188 |
"torg": [
|
| 4189 |
-
"thoracic oncology research
|
| 4190 |
-
"thoracic oncology research
|
| 4191 |
],
|
| 4192 |
"wjog": [
|
| 4193 |
"west japan oncology group"
|
|
@@ -4196,8 +4196,8 @@
|
|
| 4196 |
"trial steering committee"
|
| 4197 |
],
|
| 4198 |
"idmc": [
|
| 4199 |
-
"committee",
|
| 4200 |
-
"
|
| 4201 |
],
|
| 4202 |
"ukiog": [
|
| 4203 |
"ireland oesophagogastric group"
|
|
@@ -4295,10 +4295,10 @@
|
|
| 4295 |
"diffuse idiopathic pulmonary neuroendocrine cell hyperplasia"
|
| 4296 |
],
|
| 4297 |
"port": [
|
| 4298 |
-
"postoperative radiotherapy",
|
| 4299 |
-
"radiotherapy",
|
| 4300 |
"what is the current evidence and recommendation for postoperative radiotherapy",
|
| 4301 |
-
"
|
|
|
|
|
|
|
| 4302 |
],
|
| 4303 |
"i-v": [
|
| 4304 |
"classification system showing five levels of evidence"
|
|
|
|
| 4 |
"esmo"
|
| 5 |
],
|
| 6 |
"esmo": [
|
| 7 |
+
"european society for medical oncology",
|
| 8 |
"the european society for medical\noncology",
|
| 9 |
+
"european\nsociety of medical oncology",
|
| 10 |
"european society of medical oncology",
|
|
|
|
| 11 |
"european society for\nmedical oncology",
|
| 12 |
+
"the european society for medical oncology"
|
|
|
|
| 13 |
],
|
| 14 |
"american society of clinical\n\noncology": [
|
| 15 |
"asco"
|
| 16 |
],
|
| 17 |
"asco": [
|
| 18 |
"american society of clinical\n\noncology",
|
|
|
|
|
|
|
| 19 |
"s note\n\nthis american society of clinical oncology",
|
|
|
|
| 20 |
"journal of clinical oncology",
|
| 21 |
+
"inc",
|
| 22 |
+
"american\nsociety of clinical oncology",
|
| 23 |
+
"md american society of clinical oncology",
|
| 24 |
+
"american society of clinical oncology"
|
| 25 |
],
|
| 26 |
"italian association of medical oncology": [
|
| 27 |
"aiom"
|
| 28 |
],
|
| 29 |
"aiom": [
|
| 30 |
+
"italian association of medical oncology",
|
| 31 |
+
"italian association\nof medical oncology"
|
| 32 |
],
|
| 33 |
"national comprehensive cancer network": [
|
| 34 |
"nccn"
|
| 35 |
],
|
| 36 |
"nccn": [
|
| 37 |
"national comprehensive cancer network",
|
| 38 |
+
"vs insurance-based",
|
| 39 |
+
"leading american cancer centers"
|
| 40 |
],
|
| 41 |
"non-small cell lung cancer": [
|
| 42 |
"nsclc"
|
| 43 |
],
|
| 44 |
"nsclc": [
|
|
|
|
|
|
|
|
|
|
| 45 |
"non-small-cell lung cancer",
|
| 46 |
+
"iii non-small-cell lung cancer",
|
| 47 |
"small cell lung cancer",
|
|
|
|
|
|
|
| 48 |
"small-cell\nlung cancer",
|
| 49 |
+
"advanced non-small cell lung cancer",
|
|
|
|
|
|
|
| 50 |
"lung cancer",
|
| 51 |
"non-small cell lung cancer",
|
| 52 |
+
"small-cell lung cancer",
|
| 53 |
"cancer",
|
| 54 |
+
"e-mutant advanced non-small cell lung cancer",
|
| 55 |
"small cell\nlung cancer",
|
| 56 |
+
"advanced non-small-cell lung cancer",
|
| 57 |
+
"-rearranged advanced non-small-cell lung cancer",
|
| 58 |
+
"robotic lobectomy for non-small cell lung cancer",
|
| 59 |
+
"mutant advanced non-small cell lung cancer",
|
| 60 |
+
"stage iii non small cell lung cancer"
|
| 61 |
],
|
| 62 |
"american\nsociety of clinical oncology": [
|
| 63 |
"asco"
|
|
|
|
| 76 |
],
|
| 77 |
"glides": [
|
| 78 |
"guidelines into decision support",
|
| 79 |
+
"using the guidelines into decision\nsupport",
|
| 80 |
+
"using the guidelines into decision support"
|
| 81 |
],
|
| 82 |
"for all the newly\neuropean medicines agency": [
|
| 83 |
"ema"
|
| 84 |
],
|
| 85 |
"ema": [
|
|
|
|
|
|
|
|
|
|
| 86 |
"for all the newly\neuropean medicines agency",
|
| 87 |
+
"and the european medicines\nagency",
|
| 88 |
+
"european medicines agency",
|
| 89 |
"not european medicines agency",
|
| 90 |
+
"for all the newly european medicines agency",
|
| 91 |
+
"and the european medicines agency"
|
| 92 |
],
|
| 93 |
"evaluates treatments with curative intent": [
|
| 94 |
"such\nas adjuvant chemotherapy",
|
|
|
|
| 131 |
"bsc"
|
| 132 |
],
|
| 133 |
"bsc": [
|
|
|
|
|
|
|
| 134 |
"or best supportive care",
|
| 135 |
+
"or best supportive\ncare",
|
| 136 |
+
"leads to increased dfs versus best supportive care",
|
| 137 |
+
"leads to\nincreased dfs versus best supportive care"
|
| 138 |
],
|
| 139 |
"author affiliations\nand support\n\ninformation": [
|
| 140 |
"if\n\napplicable"
|
|
|
|
| 152 |
"rcts"
|
| 153 |
],
|
| 154 |
"rcts": [
|
| 155 |
+
"controlled trials",
|
| 156 |
"clinical trials",
|
| 157 |
+
"two randomized control trials"
|
|
|
|
| 158 |
],
|
| 159 |
"the primary end point was disease-free\nsurvival": [
|
| 160 |
"dfs"
|
| 161 |
],
|
| 162 |
"dfs": [
|
|
|
|
| 163 |
"disease-free survival",
|
| 164 |
+
"the primary end point was disease-free\nsurvival",
|
| 165 |
+
"the primary end point was disease-free survival"
|
| 166 |
],
|
| 167 |
"joint cancer care ontario": [
|
| 168 |
"cco"
|
|
|
|
| 177 |
"inst"
|
| 178 |
],
|
| 179 |
"inst": [
|
| 180 |
+
"advaxis",
|
| 181 |
+
"bristol myers squibb",
|
| 182 |
+
"blueprint medicines",
|
| 183 |
+
"dizal pharma",
|
| 184 |
"crispr\ntherapeutics",
|
| 185 |
+
"astex pharmaceuticals",
|
| 186 |
+
"revolution medicines",
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 187 |
"black diamond therapeutics",
|
| 188 |
+
"verastem",
|
| 189 |
"msd",
|
| 190 |
+
"sutro biopharma",
|
| 191 |
+
"novartis",
|
| 192 |
+
"bristol myers\nsquibb",
|
| 193 |
+
"merck",
|
| 194 |
+
"oncomed",
|
| 195 |
+
"gsk",
|
| 196 |
+
"black diamond\ntherapeutics",
|
| 197 |
+
"therapeutics",
|
| 198 |
"guardant health",
|
| 199 |
+
"crispr therapeutics",
|
| 200 |
+
"jazz pharmaceuticals",
|
| 201 |
+
"amgen",
|
| 202 |
+
"calithera biosciences",
|
| 203 |
+
"oric pharmaceuticals",
|
| 204 |
+
"inc",
|
| 205 |
+
"dohme",
|
| 206 |
+
"bristol-myers squibb",
|
| 207 |
+
"astra zeneca",
|
| 208 |
+
"harpoon therapeutics",
|
| 209 |
"pfizer",
|
| 210 |
+
"bms",
|
| 211 |
+
"nuvation bio",
|
| 212 |
+
"turning point therapeutics",
|
| 213 |
"pharmamar",
|
| 214 |
+
"trizell",
|
| 215 |
+
"roche",
|
| 216 |
+
"arcus biosciences",
|
|
|
|
|
|
|
| 217 |
"summit therapeutics",
|
| 218 |
+
"astrazeneca",
|
| 219 |
+
"astrazeneca canada",
|
| 220 |
+
"lilly",
|
| 221 |
+
"forward",
|
| 222 |
+
"neogenomics",
|
| 223 |
"takeda",
|
| 224 |
+
"medimmune",
|
|
|
|
| 225 |
"abbvie",
|
|
|
|
| 226 |
"dizal\npharma",
|
| 227 |
+
"janssen oncology",
|
| 228 |
+
"glaxosmithkline canada",
|
| 229 |
+
"polaris",
|
| 230 |
+
"mirati therapeutics",
|
| 231 |
"puma biotechnology",
|
| 232 |
+
"cullinan oncology",
|
| 233 |
+
"glaxosmithkline",
|
| 234 |
+
"constellation pharmaceuticals",
|
| 235 |
"vivace therapeutics",
|
| 236 |
+
"palobiofarma",
|
| 237 |
+
"bristol myers squibb foundation",
|
|
|
|
|
|
|
|
|
|
|
|
|
| 238 |
"bayer",
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 239 |
"boehringer ingelheim",
|
| 240 |
+
"regeneron",
|
| 241 |
+
"inhibrx",
|
| 242 |
+
"exelixis",
|
| 243 |
+
"merck serono",
|
| 244 |
+
"janssen",
|
| 245 |
+
"macrogenics",
|
| 246 |
+
"elevation oncology",
|
| 247 |
+
"genentech",
|
| 248 |
+
"anheart therapeutics"
|
| 249 |
],
|
| 250 |
"pfizer": [
|
| 251 |
"inst"
|
|
|
|
| 254 |
"inst"
|
| 255 |
],
|
| 256 |
"bristol-myers squibb": [
|
| 257 |
+
"inst",
|
| 258 |
+
"bms"
|
| 259 |
],
|
| 260 |
"medimmune": [
|
| 261 |
"inst"
|
|
|
|
| 304 |
"continued"
|
| 305 |
],
|
| 306 |
"continued": [
|
| 307 |
+
"all recommendations",
|
| 308 |
"the bottom line",
|
| 309 |
+
"medical guideline document - esmo open references"
|
| 310 |
],
|
| 311 |
"salvage stereotactic body radiation therapy": [
|
| 312 |
"sbrt"
|
| 313 |
],
|
| 314 |
"sbrt": [
|
| 315 |
+
"stereotactic body radiotherapy",
|
| 316 |
"salvage stereotactic body radiation therapy",
|
|
|
|
| 317 |
"sabr or stereotactic body radiotherapy",
|
| 318 |
+
"fdg-pet and stereotactic body radiotherapy"
|
| 319 |
],
|
| 320 |
"oncomed": [
|
| 321 |
"inst"
|
|
|
|
| 330 |
"cap"
|
| 331 |
],
|
| 332 |
"cap": [
|
| 333 |
+
"thecollege of americanpathologists",
|
| 334 |
+
"the college of american pathologists"
|
| 335 |
],
|
| 336 |
"association\nfor molecular pathology": [
|
| 337 |
"amp"
|
| 338 |
],
|
| 339 |
"amp": [
|
| 340 |
+
"association for molecular pathology",
|
| 341 |
+
"association\nfor molecular pathology"
|
| 342 |
],
|
| 343 |
"and anaplastic lymphoma kinase": [
|
| 344 |
"alk"
|
| 345 |
],
|
| 346 |
"alk": [
|
|
|
|
|
|
|
| 347 |
"crizotinib-pretreated anaplastic lymphoma kinase",
|
| 348 |
+
"positive anaplastic lymphoma kinase",
|
| 349 |
+
"and anaplastic lymphoma kinase",
|
| 350 |
+
"phoma kinase"
|
| 351 |
],
|
| 352 |
"immunohistochemistry": [
|
| 353 |
"ihc"
|
| 354 |
],
|
| 355 |
"ihc": [
|
| 356 |
+
"immunohistochemistry",
|
| 357 |
+
"egfr fish or immunohistochemistry"
|
| 358 |
],
|
| 359 |
"merck": [
|
| 360 |
+
"inst",
|
| 361 |
+
"german"
|
| 362 |
],
|
| 363 |
"glaxosmithkline": [
|
| 364 |
"gsk",
|
|
|
|
| 371 |
"inst"
|
| 372 |
],
|
| 373 |
"bristol myers\nsquibb": [
|
| 374 |
+
"inst",
|
| 375 |
+
"bms"
|
| 376 |
],
|
| 377 |
"polaris": [
|
| 378 |
"inst"
|
|
|
|
| 411 |
"icis"
|
| 412 |
],
|
| 413 |
"icis": [
|
| 414 |
+
"neoadjuvant immune checkpoint inhibitors",
|
| 415 |
+
"immune checkpoint inhibitors"
|
| 416 |
],
|
| 417 |
"american society of clinical oncology": [
|
| 418 |
"asco"
|
|
|
|
| 433 |
"inst"
|
| 434 |
],
|
| 435 |
"bms": [
|
| 436 |
+
"bristol myers squibb",
|
| 437 |
"inst",
|
| 438 |
+
"bristol-myers squibb",
|
| 439 |
"bristol myers\nsquibb",
|
| 440 |
+
"bristol-myers\nsquibb",
|
| 441 |
"celgene",
|
| 442 |
+
"bristol\nmyers squibb"
|
|
|
|
|
|
|
| 443 |
],
|
| 444 |
"trizell": [
|
| 445 |
"inst"
|
|
|
|
| 457 |
"rct"
|
| 458 |
],
|
| 459 |
"rct": [
|
| 460 |
+
"phase iib\nrandomised controlled trial",
|
| 461 |
"phase iib randomised controlled trial",
|
|
|
|
| 462 |
"a phase iii randomised clinical trial",
|
| 463 |
+
"phase iii randomised clinical trial",
|
| 464 |
+
"one randomized controlled trial"
|
| 465 |
],
|
| 466 |
"the primary end point of progression-free survival": [
|
| 467 |
"pfs"
|
| 468 |
],
|
| 469 |
"pfs": [
|
|
|
|
|
|
|
|
|
|
|
|
|
| 470 |
"and progression-free survival",
|
| 471 |
+
"the median progression-free survival",
|
| 472 |
"quality of life and progression-free survival",
|
| 473 |
+
"reported improved progression-free survival",
|
|
|
|
| 474 |
"reported improved\nprogression-free survival",
|
| 475 |
+
"the primary end point of progression-free survival",
|
| 476 |
+
"the median\nprogression-free survival",
|
| 477 |
+
"progression-free survival",
|
| 478 |
+
"the median progression-free\nsurvival",
|
| 479 |
+
"no\nimprovement in progression-free survival",
|
| 480 |
+
"and\nprogression-free survival"
|
| 481 |
],
|
| 482 |
"adverse events": [
|
| 483 |
"aes",
|
|
|
|
| 485 |
],
|
| 486 |
"aes": [
|
| 487 |
"mainly altered lipid levels",
|
| 488 |
+
"adverse\nevents",
|
| 489 |
+
"adverse events"
|
| 490 |
],
|
| 491 |
"and consolidation": [
|
| 492 |
"for unresectable stage iii nsclc"
|
|
|
|
| 498 |
"osimertinib"
|
| 499 |
],
|
| 500 |
"osimertinib": [
|
| 501 |
+
"treatment is now an egfr-targeted drug",
|
| 502 |
"osi",
|
| 503 |
+
"treatment is now an\negfr-targeted drug"
|
| 504 |
],
|
| 505 |
"inc": [
|
| 506 |
+
"inst",
|
| 507 |
+
"asco"
|
| 508 |
],
|
| 509 |
"small cell\nlung cancer": [
|
| 510 |
"nsclc"
|
|
|
|
| 519 |
"vegf"
|
| 520 |
],
|
| 521 |
"vegf": [
|
| 522 |
+
"and vascular\nendothelial growth factor",
|
| 523 |
+
"and vascular endothelial growth factor"
|
| 524 |
],
|
| 525 |
"though rates of\nimmune-related aes": [
|
| 526 |
"iraes"
|
|
|
|
| 530 |
"though rates of immune-related aes"
|
| 531 |
],
|
| 532 |
"bristol myers squibb": [
|
| 533 |
+
"inst",
|
| 534 |
+
"bms"
|
| 535 |
],
|
| 536 |
"palobiofarma": [
|
| 537 |
"inst"
|
| 538 |
],
|
| 539 |
"dohme": [
|
| 540 |
+
"inst",
|
| 541 |
+
"msd"
|
| 542 |
],
|
| 543 |
"mirati therapeutics": [
|
| 544 |
"inst"
|
|
|
|
| 565 |
"inst"
|
| 566 |
],
|
| 567 |
"gsk": [
|
| 568 |
+
"inst",
|
| 569 |
+
"glaxosmithkline"
|
| 570 |
],
|
| 571 |
"regeneron": [
|
| 572 |
"inst"
|
|
|
|
| 624 |
"health research methods"
|
| 625 |
],
|
| 626 |
"health research methods": [
|
| 627 |
+
"va asco practice guidelines staff",
|
|
|
|
| 628 |
"asco practice guideline staff",
|
| 629 |
+
"asco practice guidelines staff",
|
| 630 |
+
"va asco practice guideline staff"
|
| 631 |
],
|
| 632 |
"in tyrosine kinase inhibitor": [
|
| 633 |
"tki"
|
| 634 |
],
|
| 635 |
"tki": [
|
| 636 |
+
"tyrosine kinase inhibitor",
|
| 637 |
+
"in tyrosine kinase inhibitor"
|
| 638 |
],
|
| 639 |
"reuss et al\n\n\n\nrate": [
|
| 640 |
"orr"
|
| 641 |
],
|
| 642 |
"orr": [
|
| 643 |
+
"rate",
|
| 644 |
"which had an overall response rate",
|
|
|
|
| 645 |
"- objective response rate",
|
| 646 |
+
"reuss et al\n\n\n\nrate"
|
| 647 |
],
|
| 648 |
"disease control rate": [
|
| 649 |
"dcr"
|
|
|
|
| 661 |
"dor"
|
| 662 |
],
|
| 663 |
"dor": [
|
| 664 |
+
"- duration of response",
|
| 665 |
+
"the median duration of response",
|
| 666 |
"the median\nduration of response",
|
| 667 |
"with a median duration of response",
|
| 668 |
+
"with a median duration of\nresponse"
|
|
|
|
|
|
|
| 669 |
],
|
| 670 |
"the most common treatment-emergent adverse events": [
|
| 671 |
"teaes"
|
|
|
|
| 692 |
"inst"
|
| 693 |
],
|
| 694 |
"msd": [
|
| 695 |
+
"inst",
|
| 696 |
+
"dohme"
|
| 697 |
],
|
| 698 |
"lilly": [
|
| 699 |
"inst"
|
|
|
|
| 717 |
"cancer care ontario"
|
| 718 |
],
|
| 719 |
"cancer care ontario": [
|
| 720 |
+
"was published by asco and ontario health",
|
| 721 |
+
"asco-ontario health"
|
| 722 |
],
|
| 723 |
"the median progression-free\nsurvival": [
|
| 724 |
"pfs"
|
|
|
|
| 734 |
],
|
| 735 |
"durvalumab": [
|
| 736 |
"if ps improves\n\nv\n\nconsolidation immunotherapy",
|
| 737 |
+
"consolidation immunotherapy",
|
| 738 |
+
"if ps improves\n- consolidation immunotherapy"
|
| 739 |
],
|
| 740 |
"if ps improves\n\nv\n\nconsolidation immunotherapy": [
|
| 741 |
"durvalumab"
|
|
|
|
| 750 |
"bite"
|
| 751 |
],
|
| 752 |
"bite": [
|
| 753 |
+
"a bispecific t-cell engager",
|
| 754 |
+
"a bispecific t-cell\nengager"
|
| 755 |
],
|
| 756 |
"the most\ncommon ae was cytokine release syndrome": [
|
| 757 |
"crs"
|
| 758 |
],
|
| 759 |
"crs": [
|
| 760 |
+
"the most common ae was cytokine release syndrome",
|
| 761 |
"the most\ncommon ae was cytokine release syndrome",
|
| 762 |
+
"cytokine release syndrome"
|
|
|
|
| 763 |
],
|
| 764 |
"asco-ontario health": [
|
| 765 |
"cancer care ontario"
|
|
|
|
| 784 |
],
|
| 785 |
"fda": [
|
| 786 |
"or food and drug administration",
|
|
|
|
|
|
|
| 787 |
"entrectinib received food and drug administration",
|
| 788 |
+
"entrectinib received food and\ndrug administration",
|
|
|
|
| 789 |
"food and drug administration",
|
| 790 |
+
"the food and drug administration",
|
| 791 |
+
"and the united states food and drug administration",
|
| 792 |
+
"the us food and drug administration",
|
| 793 |
+
"and the food and drug administration"
|
| 794 |
],
|
| 795 |
"cytokine release syndrome": [
|
| 796 |
"crs"
|
|
|
|
| 813 |
],
|
| 814 |
"nets": [
|
| 815 |
"tumors",
|
| 816 |
+
"has grouped lung and thymic neuroendocrine tumours",
|
| 817 |
+
"has grouped lung and thymic neuroendocrine\ntumours"
|
| 818 |
],
|
| 819 |
"small cell lung cancer": [
|
| 820 |
"nsclc",
|
|
|
|
| 824 |
"lcnec"
|
| 825 |
],
|
| 826 |
"lcnec": [
|
| 827 |
+
"and large cell neuroendocrine carcinoma",
|
| 828 |
+
"and\nlarge cell neuroendocrine carcinoma"
|
| 829 |
],
|
| 830 |
"and thymic\ncarcinoid": [
|
| 831 |
"thc"
|
| 832 |
],
|
| 833 |
"thc": [
|
| 834 |
+
"and thymic\ncarcinoid",
|
| 835 |
+
"and thymic carcinoid"
|
| 836 |
],
|
| 837 |
"org": [
|
| 838 |
"esmo guidelines committee"
|
|
|
|
| 888 |
"ssas"
|
| 889 |
],
|
| 890 |
"ssas": [
|
|
|
|
| 891 |
"medical options",
|
| 892 |
+
"-labelled somatostatin analogues",
|
| 893 |
"what is the role of somatostatin analogues"
|
| 894 |
],
|
| 895 |
"urinary-free cortisol": [
|
|
|
|
| 935 |
"cht"
|
| 936 |
],
|
| 937 |
"cht": [
|
|
|
|
| 938 |
"the addition of the chemotherapy",
|
|
|
|
|
|
|
| 939 |
"over platinum-based doublet\nchemotherapy",
|
| 940 |
+
"mainly cytotoxic chemotherapy",
|
| 941 |
+
"chemotherapy",
|
| 942 |
+
"platinum-based chemo\ntherapy",
|
| 943 |
"with or without prior adjuvant chemotherapy",
|
| 944 |
+
"over platinum-based doublet chemotherapy",
|
| 945 |
+
"platinum-based chemotherapy",
|
| 946 |
+
"the beneficial effects of adjuvant chemotherapy"
|
| 947 |
],
|
| 948 |
"or systemic therapies": [
|
| 949 |
+
"with options\ndiscussed in these guidelines",
|
| 950 |
+
"with options discussed in these guidelines"
|
| 951 |
],
|
| 952 |
"with options\ndiscussed in these guidelines": [
|
| 953 |
"or systemic therapies"
|
|
|
|
| 956 |
"functioning syndrome"
|
| 957 |
],
|
| 958 |
"functioning syndrome": [
|
| 959 |
+
"in case of clinical",
|
| 960 |
+
"in case of\nclinical"
|
| 961 |
],
|
| 962 |
"and the united states food and drug administration": [
|
| 963 |
"fda"
|
|
|
|
| 973 |
"rfa"
|
| 974 |
],
|
| 975 |
"rfa": [
|
| 976 |
+
"for these patients radiofrequency ablation",
|
| 977 |
"palliative surgery\nor radiofrequency ablation",
|
| 978 |
+
"palliative surgery or radiofrequency ablation"
|
|
|
|
| 979 |
],
|
| 980 |
"or cryoablation or endobronchial treatment": [
|
| 981 |
"ebt"
|
|
|
|
| 987 |
"prrt"
|
| 988 |
],
|
| 989 |
"prrt": [
|
| 990 |
+
"peptide receptor radionuclide therapy",
|
| 991 |
+
"peptide\nreceptor radionuclide therapy"
|
| 992 |
],
|
| 993 |
"and interferon- a": [
|
| 994 |
"ifna"
|
|
|
|
| 1040 |
"-fluorouracil"
|
| 1041 |
],
|
| 1042 |
"as alternative second-line": [
|
| 1043 |
+
"in case of uncontrolled cs",
|
| 1044 |
+
"in case of\nuncontrolled cs"
|
| 1045 |
],
|
| 1046 |
"in case of\nuncontrolled cs": [
|
| 1047 |
"as alternative second-line"
|
|
|
|
| 1074 |
"thymic net recurrences may be local"
|
| 1075 |
],
|
| 1076 |
"regional": [
|
| 1077 |
+
"intrathoracic especially pleural",
|
| 1078 |
+
"intrathoracic especially\npleural"
|
| 1079 |
],
|
| 1080 |
"intrathoracic especially\npleural": [
|
| 1081 |
"regional"
|
|
|
|
| 1085 |
],
|
| 1086 |
"esmo-mcbs": [
|
| 1087 |
"esmo-magnitude of clinical\nbenefit",
|
|
|
|
|
|
|
|
|
|
| 1088 |
"an esmo\nmagnitude of clinical benefit scale",
|
| 1089 |
"esmo-magnitude of clinical benefit",
|
| 1090 |
+
"esmomagnitude of clinical benefit scale",
|
| 1091 |
+
"an esmo magnitude of clinical benefit scale",
|
| 1092 |
+
"esmo-magnitude of clinical benefit scale",
|
| 1093 |
+
"esmo-magnitude of\nclinical benefit"
|
| 1094 |
],
|
| 1095 |
"advanced carcinoids of the lung and thymus": [
|
| 1096 |
"luna"
|
|
|
|
| 1144 |
"chuv"
|
| 1145 |
],
|
| 1146 |
"chuv": [
|
| 1147 |
+
"centre hospitalier universitaire\nvaudois",
|
| 1148 |
+
"centre hospitalier universitaire vaudois"
|
| 1149 |
],
|
| 1150 |
"comparing low-dose computed tomography": [
|
| 1151 |
"ldct"
|
| 1152 |
],
|
| 1153 |
"ldct": [
|
| 1154 |
+
"low-dose ct",
|
| 1155 |
+
"comparing low-dose computed tomography"
|
| 1156 |
],
|
| 1157 |
"such as lepidic adenocarcinomas": [
|
| 1158 |
"previously named bronchioloalveolar carcinoma"
|
|
|
|
| 1177 |
"who"
|
| 1178 |
],
|
| 1179 |
"who": [
|
| 1180 |
+
"the recent world health organization",
|
| 1181 |
"world health organization",
|
|
|
|
| 1182 |
"global",
|
| 1183 |
+
"vs universal",
|
| 1184 |
+
"global statistics"
|
| 1185 |
],
|
| 1186 |
"with its further sub-classification of": [
|
| 1187 |
"surgically resected"
|
|
|
|
| 1196 |
"ais"
|
| 1197 |
],
|
| 1198 |
"ais": [
|
|
|
|
| 1199 |
"proposed that ais be classified as tis",
|
| 1200 |
+
"the categories adenocarcinoma in situ",
|
| 1201 |
"proposed\nthat ais be classified as tis"
|
| 1202 |
],
|
| 1203 |
"minimally invasive adenocarcinoma": [
|
|
|
|
| 1229 |
"uicc"
|
| 1230 |
],
|
| 1231 |
"uicc": [
|
| 1232 |
+
"union for international cancer control",
|
|
|
|
| 1233 |
"union for international\ncancer control",
|
| 1234 |
+
"the union for international cancer control",
|
| 1235 |
+
"the union for\ninternational cancer control"
|
| 1236 |
],
|
| 1237 |
"node and metastasis": [
|
| 1238 |
"tnm"
|
| 1239 |
],
|
| 1240 |
"tnm": [
|
| 1241 |
+
"node and metastasis",
|
| 1242 |
"tumour-node-metastasis",
|
| 1243 |
+
"tumourenodeemetastasis"
|
| 1244 |
],
|
| 1245 |
"proposed\nthat ais be classified as tis": [
|
| 1246 |
"ais"
|
|
|
|
| 1268 |
"accp"
|
| 1269 |
],
|
| 1270 |
"accp": [
|
| 1271 |
+
"the\namerican college of chest physicians",
|
| 1272 |
"whereas the american college of chest physicians",
|
| 1273 |
+
"the american college of chest physicians"
|
| 1274 |
],
|
| 1275 |
"adjuvant chemotherapy": [
|
| 1276 |
"radiotherapy"
|
|
|
|
| 1282 |
"vats"
|
| 1283 |
],
|
| 1284 |
"vats": [
|
| 1285 |
+
"video-assisted thoracic surgery",
|
| 1286 |
+
"or a video-assisted thoracoscopic surgery"
|
| 1287 |
],
|
| 1288 |
"based on the lung cancer study group": [
|
| 1289 |
"lcsg"
|
|
|
|
| 1347 |
"neo"
|
| 1348 |
],
|
| 1349 |
"neo": [
|
| 1350 |
+
"the\nimmune strategy in the",
|
| 1351 |
"- immunotherapy is being studied in early nsclc as",
|
| 1352 |
"immunotherapy is being studied in early nsclc as",
|
| 1353 |
+
"resection and after",
|
| 1354 |
"the immune strategy in the"
|
| 1355 |
],
|
| 1356 |
"cl\n\ntreatment of locally advanced stage": [
|
|
|
|
| 1385 |
],
|
| 1386 |
"ests": [
|
| 1387 |
"and the european\nsociety of thoracic surgeons",
|
| 1388 |
+
"and the european society of thoracic surgeons",
|
| 1389 |
+
"and european society of thoracic surgeons"
|
| 1390 |
],
|
| 1391 |
"gv scagliotti": [
|
| 1392 |
"eds"
|
|
|
|
| 1408 |
"pulmonology"
|
| 1409 |
],
|
| 1410 |
"pulmonology": [
|
| 1411 |
+
"respiratory oncology",
|
| 1412 |
+
"respiratory oncology unit"
|
| 1413 |
],
|
| 1414 |
"edegem": [
|
| 1415 |
"antwerp"
|
|
|
|
| 1430 |
"stage iii"
|
| 1431 |
],
|
| 1432 |
"stage iii": [
|
| 1433 |
+
"locally advanced nsclc",
|
| 1434 |
+
"- locally advanced nsclc",
|
| 1435 |
"unresectable nsclc",
|
| 1436 |
"treatment of locally advanced stage",
|
| 1437 |
+
"and unresectable locally advanced"
|
|
|
|
| 1438 |
],
|
| 1439 |
"in paral\npractice guidelines": [
|
| 1440 |
"cpgs"
|
|
|
|
| 1446 |
"see panel members listed in the appendix"
|
| 1447 |
],
|
| 1448 |
"see panel members listed in the appendix": [
|
|
|
|
| 1449 |
"experts were involved in this consensus process",
|
| 1450 |
+
"and a general consen\nconsensus process",
|
| 1451 |
+
"experts were involved in this\nconsensus process"
|
| 1452 |
],
|
| 1453 |
"experts were involved in this\nconsensus process": [
|
| 1454 |
"see panel members listed in the appendix"
|
|
|
|
| 1466 |
"as relative value depends on personal"
|
| 1467 |
],
|
| 1468 |
"respiratory literature": [
|
| 1469 |
+
"especially on exercise testing",
|
| 1470 |
+
"especially on exercise\ntesting"
|
| 1471 |
],
|
| 1472 |
"especially on exercise\ntesting": [
|
| 1473 |
"respiratory literature"
|
|
|
|
| 1581 |
"pbc"
|
| 1582 |
],
|
| 1583 |
"pbc": [
|
| 1584 |
+
"platinum-based doublet chemotherapy",
|
| 1585 |
"five cycles of tremelimumab",
|
| 1586 |
+
"five cycles of\n\ntremelimumab"
|
|
|
|
| 1587 |
],
|
| 1588 |
"carboplatin": [
|
| 1589 |
+
"arm a",
|
| 1590 |
+
"arm b"
|
| 1591 |
],
|
| 1592 |
"arm a": [
|
| 1593 |
"carboplatin"
|
|
|
|
| 1606 |
"primary endpoint"
|
| 1607 |
],
|
| 1608 |
"primary endpoint": [
|
| 1609 |
+
"-year os",
|
|
|
|
| 1610 |
"pbc significantly improved pfs",
|
| 1611 |
"level",
|
| 1612 |
+
"significantly improved os",
|
| 1613 |
+
"pbc\nsignificantly improved pfs"
|
| 1614 |
],
|
| 1615 |
"besides immune checkpoint\n\ninhibitor": [
|
| 1616 |
"ici"
|
| 1617 |
],
|
| 1618 |
"ici": [
|
|
|
|
| 1619 |
"besides immune checkpoint\n\ninhibitor",
|
| 1620 |
+
"and have no prior immune checkpoint inhibitor",
|
| 1621 |
+
"besides immune checkpoint inhibitor"
|
| 1622 |
],
|
| 1623 |
"esmo-magnitude of clinical benefit scale": [
|
| 1624 |
+
"esmo-mcbs",
|
| 1625 |
+
"mcbs"
|
| 1626 |
],
|
| 1627 |
"mcbs": [
|
| 1628 |
"esmo-magnitude of clinical benefit scale"
|
|
|
|
| 1652 |
"ttfields"
|
| 1653 |
],
|
| 1654 |
"ttfields": [
|
| 1655 |
+
"tumour treating\nfields",
|
| 1656 |
+
"tumour treating fields"
|
| 1657 |
],
|
| 1658 |
"significantly improved os": [
|
| 1659 |
"primary endpoint"
|
|
|
|
| 1662 |
"esmo guidelines staff"
|
| 1663 |
],
|
| 1664 |
"esmo guidelines staff": [
|
| 1665 |
+
"jennifer\nlamarre and guy atchison",
|
| 1666 |
"ioanna ntai and claire bramley",
|
| 1667 |
"jennifer lamarre and guy atchison",
|
|
|
|
| 1668 |
"valerie laforest"
|
| 1669 |
],
|
| 1670 |
"valerie laforest": [
|
| 1671 |
+
"esmo\nguidelines staff",
|
| 1672 |
+
"esmo guidelines staff"
|
| 1673 |
],
|
| 1674 |
"esmo\nguidelines staff": [
|
| 1675 |
"valerie laforest"
|
|
|
|
| 1678 |
"esmo scientific affairs staff"
|
| 1679 |
],
|
| 1680 |
"esmo scientific affairs staff": [
|
| 1681 |
+
"nicola\nlatino",
|
|
|
|
|
|
|
| 1682 |
"nicola\nlatino and francesca chiovaro",
|
| 1683 |
+
"nicola latino and\nfrancesca chiovaro",
|
| 1684 |
+
"nicola latino and francesca chiovaro",
|
| 1685 |
+
"nicola latino"
|
| 1686 |
],
|
| 1687 |
"bristol\nmyers squibb": [
|
| 1688 |
"bms"
|
|
|
|
| 1700 |
"ipsos"
|
| 1701 |
],
|
| 1702 |
"ipsos": [
|
| 1703 |
+
"roche and regimen",
|
| 1704 |
+
"with a platinum-containing\nregimen"
|
| 1705 |
],
|
| 1706 |
"esmo clinical practice guideline": [
|
| 1707 |
"cpg"
|
|
|
|
| 1719 |
"ngs"
|
| 1720 |
],
|
| 1721 |
"ngs": [
|
|
|
|
| 1722 |
"by next-generation sequencing",
|
| 1723 |
+
"such as next-generation sequencing",
|
| 1724 |
+
"multiplex platforms"
|
| 1725 |
],
|
| 1726 |
"egfr fish or immunohistochemistry": [
|
| 1727 |
"ihc"
|
|
|
|
| 1733 |
"ntrk"
|
| 1734 |
],
|
| 1735 |
"ntrk": [
|
| 1736 |
+
"and the neurotrophic receptor tyrosine\nkinase",
|
|
|
|
| 1737 |
"or neurotrophic tyrosine\nreceptor kinase",
|
| 1738 |
+
"- the neurotrophic receptor tyrosine kinase",
|
| 1739 |
+
"or neurotrophic tyrosine receptor kinase"
|
| 1740 |
],
|
| 1741 |
"detection is reliable by\nin situ hybridisation": [
|
| 1742 |
"ish"
|
| 1743 |
],
|
| 1744 |
"ish": [
|
| 1745 |
+
"detection is reliable by\nin situ hybridisation",
|
| 1746 |
+
"detection is reliable by in situ hybridisation"
|
| 1747 |
],
|
| 1748 |
"mesenchymal-epithelial transition": [
|
| 1749 |
"met"
|
|
|
|
| 1781 |
"fdg"
|
| 1782 |
],
|
| 1783 |
"fdg": [
|
| 1784 |
+
"-deoxy-d-glucose",
|
| 1785 |
+
"e\ndeoxy-d-glucose"
|
| 1786 |
],
|
| 1787 |
"union for international\ncancer control": [
|
| 1788 |
"uicc"
|
|
|
|
| 1811 |
"mos"
|
| 1812 |
],
|
| 1813 |
"mos": [
|
|
|
|
| 1814 |
"malaysian oncological society",
|
| 1815 |
"malaysia",
|
| 1816 |
+
"the malaysian oncological society",
|
| 1817 |
+
"and median os"
|
| 1818 |
],
|
| 1819 |
"systemic progression\n\nlocal treatment": [
|
| 1820 |
"surgery or ft"
|
|
|
|
| 1848 |
"japan"
|
| 1849 |
],
|
| 1850 |
"japan": [
|
| 1851 |
+
"j-alex",
|
| 1852 |
+
"jsmo"
|
| 1853 |
],
|
| 1854 |
"and\nalesia": [
|
| 1855 |
"asia"
|
| 1856 |
],
|
| 1857 |
"asia": [
|
| 1858 |
+
"and alesia",
|
| 1859 |
+
"and\nalesia"
|
| 1860 |
],
|
| 1861 |
"and continue targeted": [
|
| 1862 |
"not mandatory for decision"
|
|
|
|
| 1889 |
"mdor"
|
| 1890 |
],
|
| 1891 |
"mdor": [
|
| 1892 |
+
"the median duration of response",
|
| 1893 |
+
"the\nmedian duration of response"
|
| 1894 |
],
|
| 1895 |
"tropomyosin receptor tyrosine kinase": [
|
| 1896 |
"trk"
|
|
|
|
| 1902 |
"surgery or rt"
|
| 1903 |
],
|
| 1904 |
"surgery or rt": [
|
| 1905 |
+
"- local treatment",
|
| 1906 |
"oligoprogression\n\nlocal treatment",
|
| 1907 |
"local treatment",
|
|
|
|
| 1908 |
"disease progression\n\nlocal treatment"
|
| 1909 |
],
|
| 1910 |
"or combination therapy with a mek inhibitor": [
|
|
|
|
| 1932 |
"kras"
|
| 1933 |
],
|
| 1934 |
"kras": [
|
| 1935 |
+
"the\nkirsten rat sarcoma virus",
|
| 1936 |
+
"the kirsten rat sarcoma virus"
|
| 1937 |
],
|
| 1938 |
"data regarding the role of local ablative therapy": [
|
| 1939 |
"lat"
|
|
|
|
| 1972 |
"esmo scientific affairs staff"
|
| 1973 |
],
|
| 1974 |
"and dr svetlana jezdic": [
|
|
|
|
| 1975 |
"esmo medical affairs advisor",
|
| 1976 |
+
"esmo\nmedical affairs advisor",
|
| 1977 |
"esmo medical affairs staff"
|
| 1978 |
],
|
| 1979 |
"esmo\nmedical affairs advisor": [
|
|
|
|
| 1986 |
"atorg"
|
| 1987 |
],
|
| 1988 |
"atorg": [
|
| 1989 |
+
"asian thoracic oncology research group",
|
| 1990 |
+
"asian\nthoracic oncology research group"
|
| 1991 |
],
|
| 1992 |
"chinese lung\ncancer research foundation limited": [
|
| 1993 |
"clcrf"
|
|
|
|
| 2062 |
"asmac"
|
| 2063 |
],
|
| 2064 |
"asmac": [
|
| 2065 |
+
"s de clinique",
|
| 2066 |
+
"s\nde clinique"
|
| 2067 |
],
|
| 2068 |
"rzte": [
|
| 2069 |
"vsao"
|
|
|
|
| 2084 |
"cancers"
|
| 2085 |
],
|
| 2086 |
"relay": [
|
| 2087 |
+
"cancer",
|
| 2088 |
+
"advanced non-small-cell lung cancer"
|
| 2089 |
],
|
| 2090 |
"non-small-cell lung cancer": [
|
| 2091 |
+
"nsclc",
|
| 2092 |
+
"alesia"
|
| 2093 |
],
|
| 2094 |
"alesia": [
|
| 2095 |
"non-small-cell lung cancer"
|
|
|
|
| 2111 |
"chmp"
|
| 2112 |
],
|
| 2113 |
"chmp": [
|
|
|
|
| 2114 |
"products for human use",
|
| 2115 |
+
"retsevmo - summary of opinion",
|
| 2116 |
+
"tabrecta - summary of opinion"
|
| 2117 |
],
|
| 2118 |
"tabrecta - summary of opinion": [
|
| 2119 |
"chmp"
|
|
|
|
| 2150 |
],
|
| 2151 |
"jsmo": [
|
| 2152 |
"the\njapanese society of medical oncology",
|
| 2153 |
+
"japan",
|
| 2154 |
+
"the japanese society of medical oncology"
|
| 2155 |
],
|
| 2156 |
"korea": [
|
| 2157 |
"ksmo"
|
|
|
|
| 2166 |
"psmo"
|
| 2167 |
],
|
| 2168 |
"psmo": [
|
|
|
|
| 2169 |
"and philippine society of medical oncology",
|
|
|
|
| 2170 |
"and philippine society of medical\noncology",
|
| 2171 |
+
"the philippine society of medical oncology",
|
| 2172 |
+
"the philippines",
|
| 2173 |
"the philippine society of\nmedical oncology"
|
| 2174 |
],
|
| 2175 |
"singapore": [
|
|
|
|
| 2184 |
"tos"
|
| 2185 |
],
|
| 2186 |
"tos": [
|
| 2187 |
+
"taiwan",
|
| 2188 |
+
"the taiwan oncology society"
|
| 2189 |
],
|
| 2190 |
"and thailand": [
|
| 2191 |
"tsco"
|
| 2192 |
],
|
| 2193 |
"tsco": [
|
|
|
|
| 2194 |
"and the\nthai society of clinical oncology",
|
| 2195 |
+
"and thailand",
|
| 2196 |
"and the thai society of clinical oncology"
|
| 2197 |
],
|
| 2198 |
"and the neurotrophic receptor tyrosine\nkinase": [
|
|
|
|
| 2229 |
"tmk and hrk"
|
| 2230 |
],
|
| 2231 |
"tmk and hrk": [
|
| 2232 |
+
"only two of the six\nexpert members from the ksmo",
|
| 2233 |
+
"only two of the six expert members from the ksmo"
|
| 2234 |
],
|
| 2235 |
"performance status": [
|
| 2236 |
"ecog ps"
|
|
|
|
| 2266 |
"such as osimertinib"
|
| 2267 |
],
|
| 2268 |
"such as osimertinib": [
|
| 2269 |
+
"generation tki",
|
| 2270 |
+
"third-generation egfr tkis"
|
| 2271 |
],
|
| 2272 |
"generation tki": [
|
| 2273 |
"such as osimertinib"
|
|
|
|
| 2306 |
"traes"
|
| 2307 |
],
|
| 2308 |
"traes": [
|
| 2309 |
+
"treatment-related adverse events",
|
| 2310 |
"what are the treatment-related adverse events",
|
| 2311 |
+
"treatment-related aes"
|
| 2312 |
],
|
| 2313 |
"and have no prior immune checkpoint inhibitor": [
|
| 2314 |
"ici"
|
|
|
|
| 2326 |
"jkn"
|
| 2327 |
],
|
| 2328 |
"jkn": [
|
| 2329 |
+
"ishmo\n\n\nthe jaminan kesehatan nasional",
|
| 2330 |
+
"ishmo\n\nthe jaminan kesehatan nasional"
|
| 2331 |
],
|
| 2332 |
"there is no regulation of partial coverage": [
|
| 2333 |
"co-payment"
|
|
|
|
| 2339 |
"pap"
|
| 2340 |
],
|
| 2341 |
"pap": [
|
| 2342 |
+
"esmo open\n\n\n\nprogram",
|
| 2343 |
+
"program"
|
| 2344 |
],
|
| 2345 |
"mandatory national health insurance": [
|
| 2346 |
"nhi"
|
|
|
|
| 2368 |
"alk inhibitors"
|
| 2369 |
],
|
| 2370 |
"and atezolizumab": [
|
| 2371 |
+
"in the\nsecond-line setting",
|
| 2372 |
+
"in the second-line setting"
|
| 2373 |
],
|
| 2374 |
"in the\nsecond-line setting": [
|
| 2375 |
"and atezolizumab"
|
|
|
|
| 2385 |
"first-line"
|
| 2386 |
],
|
| 2387 |
"first-line": [
|
| 2388 |
+
"and the alk inhibitors ceritinib and brigatinib",
|
| 2389 |
+
"and the alk inhibitors ceritinib and\nbrigatinib"
|
| 2390 |
],
|
| 2391 |
"german": [
|
| 2392 |
"merck"
|
|
|
|
| 2395 |
"torg"
|
| 2396 |
],
|
| 2397 |
"torg": [
|
| 2398 |
+
"thoracic oncology research\ngroup",
|
| 2399 |
+
"thoracic oncology research group"
|
| 2400 |
],
|
| 2401 |
"and west japan oncology group": [
|
| 2402 |
"wjog"
|
|
|
|
| 2405 |
"and west japan oncology group"
|
| 2406 |
],
|
| 2407 |
"product samples": [
|
| 2408 |
+
"nonrenumerated",
|
| 2409 |
+
"non-renumerated"
|
| 2410 |
],
|
| 2411 |
"nonrenumerated": [
|
| 2412 |
"product samples"
|
|
|
|
| 2479 |
"mnsclc"
|
| 2480 |
],
|
| 2481 |
"mnsclc": [
|
| 2482 |
+
"e-mutant metastatic nsclc",
|
| 2483 |
+
"stage iv metastatic non-small-cell lung cancer"
|
| 2484 |
],
|
| 2485 |
"binimetinib in patients": [
|
| 2486 |
"pts"
|
| 2487 |
],
|
| 2488 |
"pts": [
|
|
|
|
| 2489 |
"patients",
|
|
|
|
|
|
|
|
|
|
| 2490 |
"mo encorafenib plus binimetinib in patients",
|
| 2491 |
"binimetinib in patients",
|
| 2492 |
+
"therapy in patients",
|
| 2493 |
+
"p repotrectinib in patients",
|
| 2494 |
+
"osimertinib as adjuvant therapy in patients",
|
| 2495 |
+
"versus docetaxel in patients",
|
| 2496 |
+
"mo encorafenib plus\n\nbinimetinib in patients"
|
| 2497 |
],
|
| 2498 |
"mutant advanced non-small cell lung cancer": [
|
| 2499 |
"nsclc"
|
|
|
|
| 2509 |
],
|
| 2510 |
"treatment of early stages": [
|
| 2511 |
"stages i-ii",
|
| 2512 |
+
"stages i-iiia",
|
| 2513 |
+
"stages i and ii"
|
| 2514 |
],
|
| 2515 |
"stages i-iiia": [
|
| 2516 |
"treatment of early stages"
|
|
|
|
| 2523 |
],
|
| 2524 |
"chemotherapy": [
|
| 2525 |
"- everolimus\n - cht",
|
| 2526 |
+
"cht",
|
| 2527 |
+
"adaura"
|
| 2528 |
],
|
| 2529 |
"the median\nwas not reached": [
|
| 2530 |
"ne-ne"
|
|
|
|
| 2543 |
"neo"
|
| 2544 |
],
|
| 2545 |
"or docetaxel or pemetrexed": [
|
| 2546 |
+
"only in adenocarcinoma tumours",
|
| 2547 |
+
"only in\nadenocarcinoma tumours"
|
| 2548 |
],
|
| 2549 |
"only in\nadenocarcinoma tumours": [
|
| 2550 |
"or docetaxel or pemetrexed"
|
|
|
|
| 2553 |
"port"
|
| 2554 |
],
|
| 2555 |
"port": [
|
| 2556 |
+
"postoperative radiotherapy",
|
| 2557 |
"post-operative radiotherapy",
|
| 2558 |
+
"comparing post-operative conformal radiotherapy"
|
| 2559 |
],
|
| 2560 |
"treatment of locally advanced stage": [
|
| 2561 |
"stage iii"
|
|
|
|
| 2594 |
"pacific"
|
| 2595 |
],
|
| 2596 |
"pacific": [
|
|
|
|
| 2597 |
"concurrent chemoradiation therapy",
|
| 2598 |
+
"unresectable non-small-cell lung cancer",
|
| 2599 |
+
"small-cell lung cancer"
|
| 2600 |
],
|
| 2601 |
"adaura": [
|
| 2602 |
"chemotherapy"
|
|
|
|
| 2605 |
"including stage ib"
|
| 2606 |
],
|
| 2607 |
"including stage ib": [
|
| 2608 |
+
"d approval was based on all patient data",
|
| 2609 |
+
"approval was based on all patient data"
|
| 2610 |
],
|
| 2611 |
"on tumour cells": [
|
| 2612 |
"as per the\nema-approved indication",
|
|
|
|
| 2649 |
"egfrm"
|
| 2650 |
],
|
| 2651 |
"nivolumab": [
|
| 2652 |
+
"nivo",
|
| 2653 |
+
"bristol myers squibb statement on opdivo"
|
| 2654 |
],
|
| 2655 |
"nivo": [
|
| 2656 |
"nivolumab"
|
|
|
|
| 2659 |
"chemo"
|
| 2660 |
],
|
| 2661 |
"chemo": [
|
| 2662 |
+
"platinum-based chemotherapy",
|
| 2663 |
"platinum-doublet chemotherapy",
|
| 2664 |
+
"platinum-doublet\nchemotherapy"
|
|
|
|
| 2665 |
],
|
| 2666 |
"for\nresectable": [
|
| 2667 |
"ib-iiia"
|
| 2668 |
],
|
| 2669 |
"ib-iiia": [
|
| 2670 |
+
"for resectable",
|
| 2671 |
+
"for\nresectable"
|
| 2672 |
],
|
| 2673 |
"lung cancer": [
|
| 2674 |
"nsclc"
|
|
|
|
| 2692 |
"diques august pi i sunyer"
|
| 2693 |
],
|
| 2694 |
"department of radiation oncology": [
|
| 2695 |
+
"maastro clinic",
|
| 2696 |
+
"maastro"
|
| 2697 |
],
|
| 2698 |
"maastro clinic": [
|
| 2699 |
"department of radiation oncology"
|
|
|
|
| 3215 |
"rfa"
|
| 3216 |
],
|
| 3217 |
"peptide receptor radionuclide therapy": [
|
| 3218 |
+
"- prrt",
|
| 3219 |
+
"prrt"
|
| 3220 |
],
|
| 3221 |
"what is the role of somatostatin analogues": [
|
| 3222 |
"ssas"
|
|
|
|
| 3423 |
"fda"
|
| 3424 |
],
|
| 3425 |
"the median duration of response": [
|
| 3426 |
+
"mdor",
|
| 3427 |
+
"dor"
|
| 3428 |
],
|
| 3429 |
"deruxtecan": [
|
| 3430 |
"fda approved"
|
|
|
|
| 3535 |
"author"
|
| 3536 |
],
|
| 3537 |
"author": [
|
| 3538 |
+
"hrk",
|
| 3539 |
+
"cew",
|
| 3540 |
"jchy",
|
| 3541 |
+
"sak",
|
| 3542 |
"msi",
|
| 3543 |
"tmk",
|
| 3544 |
+
"ddwl"
|
|
|
|
|
|
|
|
|
|
| 3545 |
],
|
| 3546 |
"hrk": [
|
| 3547 |
"author"
|
|
|
|
| 3661 |
},
|
| 3662 |
"abbreviations": {
|
| 3663 |
"esmo": [
|
| 3664 |
+
"european society for medical oncology",
|
| 3665 |
+
"european society for medical\noncology",
|
| 3666 |
+
"the european society for medical oncology",
|
| 3667 |
"european\nsociety of medical oncology",
|
| 3668 |
"the following european society for medical oncology",
|
| 3669 |
+
"the most recent european society for medical oncology",
|
|
|
|
| 3670 |
"living guideline\n\nthe following european society for medical oncology",
|
|
|
|
| 3671 |
"european society for\nmedical oncology",
|
| 3672 |
+
"european society of medical oncology"
|
|
|
|
| 3673 |
],
|
| 3674 |
"asco": [
|
|
|
|
| 3675 |
"american society of clinical\n\noncology",
|
|
|
|
|
|
|
|
|
|
| 3676 |
"journal of clinical oncology",
|
| 3677 |
+
"american society of clinical\noncology",
|
| 3678 |
+
"american\nsociety of clinical oncology",
|
| 3679 |
+
"the clinical practice guidelines published herein are provided by the american society of clinical oncology inc",
|
| 3680 |
+
"american society of clinical oncology",
|
| 3681 |
+
"this american society of clinical oncology"
|
| 3682 |
],
|
| 3683 |
"aiom": [
|
| 3684 |
+
"the italian association of medical oncology",
|
| 3685 |
"italian association of medical oncology",
|
| 3686 |
+
"italian association\nof medical oncology"
|
| 3687 |
],
|
| 3688 |
"nccn": [
|
| 3689 |
+
"national comprehensive cancer network",
|
| 3690 |
+
"american cancer centers"
|
| 3691 |
],
|
| 3692 |
"glides": [
|
| 3693 |
+
"ecision support",
|
| 3694 |
"guidelines into decision\nsupport",
|
| 3695 |
+
"guidelines into decision support"
|
|
|
|
| 3696 |
],
|
| 3697 |
"glc": [
|
| 3698 |
"guidelines committee"
|
| 3699 |
],
|
| 3700 |
"mcbs": [
|
| 3701 |
+
"magnitude of clinical benefit scale",
|
| 3702 |
"magnitude\nof clinical benefit score",
|
| 3703 |
+
"magnitude of clinical benefit score"
|
| 3704 |
],
|
| 3705 |
"ema": [
|
| 3706 |
"european medicines\nagency",
|
| 3707 |
"european medicines agency"
|
| 3708 |
],
|
| 3709 |
"sclc": [
|
|
|
|
|
|
|
| 3710 |
"what is the treatment algorithm for patients with small cell lung cancer",
|
| 3711 |
+
"small cell lung cancer",
|
| 3712 |
"clinical practice guidelines on small cell lung\ncancer",
|
| 3713 |
+
"clinical practice guidelines on small cell lung cancer",
|
| 3714 |
"what are the recommended treatment options for patients with relapsed small cell lung cancer"
|
| 3715 |
],
|
| 3716 |
"cco": [
|
| 3717 |
"cancer care ontario"
|
| 3718 |
],
|
| 3719 |
"astro": [
|
| 3720 |
+
"executive summary of an american society for\nradiation oncology",
|
| 3721 |
+
"executive summary of an american society for radiation oncology"
|
| 3722 |
],
|
| 3723 |
"inst": [
|
| 3724 |
+
"advaxis",
|
| 3725 |
+
"bristol myers squibb",
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 3726 |
"blueprint medicines",
|
| 3727 |
+
"dizal pharma",
|
| 3728 |
+
"astex pharmaceuticals",
|
|
|
|
|
|
|
| 3729 |
"revolution medicines",
|
| 3730 |
+
"black diamond therapeutics",
|
| 3731 |
+
"verastem",
|
| 3732 |
+
"heart therapeutics",
|
| 3733 |
+
"sutro biopharma",
|
| 3734 |
+
"novartis",
|
| 3735 |
+
"bristol myers\nsquibb",
|
| 3736 |
+
"merck",
|
| 3737 |
+
"black diamond\ntherapeutics",
|
| 3738 |
+
"therapeutics",
|
| 3739 |
+
"guardant health",
|
| 3740 |
+
"jazz pharmaceuticals",
|
| 3741 |
+
"amgen",
|
| 3742 |
+
"calithera biosciences",
|
| 3743 |
+
"genomics",
|
| 3744 |
"dohme",
|
| 3745 |
+
"astra zeneca",
|
| 3746 |
"harpoon therapeutics",
|
| 3747 |
+
"pfizer",
|
| 3748 |
+
"zeneca canada",
|
| 3749 |
"kline canada",
|
| 3750 |
+
"nuvation bio",
|
| 3751 |
+
"turning point therapeutics",
|
| 3752 |
+
"trizell",
|
| 3753 |
+
"immune",
|
| 3754 |
+
"roche",
|
| 3755 |
+
"arcus biosciences",
|
| 3756 |
+
"summit therapeutics",
|
| 3757 |
+
"myers squibb",
|
| 3758 |
+
"lilly",
|
| 3759 |
+
"forward",
|
| 3760 |
+
"regeneron",
|
| 3761 |
"takeda",
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 3762 |
"dizal\npharma",
|
| 3763 |
+
"kline",
|
| 3764 |
+
"janssen oncology",
|
| 3765 |
+
"polaris",
|
| 3766 |
+
"mirati therapeutics",
|
| 3767 |
"puma biotechnology",
|
| 3768 |
+
"cullinan oncology",
|
| 3769 |
+
"constellation pharmaceuticals",
|
| 3770 |
"vivace therapeutics",
|
| 3771 |
+
"palobiofarma",
|
| 3772 |
+
"bristol myers squibb foundation",
|
|
|
|
|
|
|
| 3773 |
"bayer",
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 3774 |
"pharmaceuticals",
|
| 3775 |
+
"boehringer ingelheim",
|
| 3776 |
+
"inhibrx",
|
| 3777 |
+
"exelixis",
|
| 3778 |
+
"merck serono",
|
| 3779 |
+
"janssen",
|
| 3780 |
+
"macrogenics",
|
| 3781 |
+
"zeneca",
|
| 3782 |
+
"elevation oncology",
|
| 3783 |
+
"genentech"
|
| 3784 |
],
|
| 3785 |
"ct": [
|
|
|
|
|
|
|
| 3786 |
"the use of\ncomputed tomography",
|
| 3787 |
+
"clinicians should use a diagnostic chest computed tomography",
|
| 3788 |
+
"the use of computed tomography",
|
| 3789 |
+
"computed tomography"
|
| 3790 |
],
|
| 3791 |
"mri": [
|
| 3792 |
"what is the role of brain magnetic resonance imaging"
|
| 3793 |
],
|
| 3794 |
"sbrt": [
|
| 3795 |
+
"stereotactic body radiotherapy",
|
| 3796 |
+
"salvage stereotactic body radiation therapy"
|
| 3797 |
],
|
| 3798 |
"cap": [
|
| 3799 |
"pathologists",
|
| 3800 |
"college of american pathologists"
|
| 3801 |
],
|
| 3802 |
"iaslc": [
|
| 3803 |
+
"international association for the\n\nstudy of lung cancer",
|
| 3804 |
+
"international association for\nthe study of lung cancer",
|
| 3805 |
+
"the international association for the study of lung cancer",
|
| 3806 |
+
"the\ninternational association for the study of lung cancer",
|
| 3807 |
"pathology committee chair for international association for the study of lung cancer",
|
| 3808 |
"study of lung cancer",
|
|
|
|
| 3809 |
"pathology committee chair\nfor international association for the study of lung cancer",
|
|
|
|
| 3810 |
"international association for the study of lung cancer",
|
| 3811 |
+
"international association for the\nstudy of lung cancer"
|
|
|
|
|
|
|
| 3812 |
],
|
| 3813 |
"amp": [
|
| 3814 |
+
"association for molecular pathology",
|
| 3815 |
+
"association\nfor molecular pathology"
|
| 3816 |
],
|
| 3817 |
"ihc": [
|
| 3818 |
"immunohistochemistry"
|
|
|
|
| 3824 |
"although the results from the mesothelioma and radical surgery"
|
| 3825 |
],
|
| 3826 |
"os": [
|
|
|
|
|
|
|
| 3827 |
"overall survival",
|
| 3828 |
"the median overall survival",
|
| 3829 |
+
"the only data published thus far pertain to the dual primary end points of overall survival",
|
| 3830 |
+
"the median\noverall survival",
|
| 3831 |
+
"median overall survival"
|
| 3832 |
],
|
| 3833 |
"elsevier": [
|
| 3834 |
"clinical lung cancer"
|
|
|
|
| 3837 |
"one randomized controlled trial"
|
| 3838 |
],
|
| 3839 |
"ps": [
|
| 3840 |
+
"eastern cooperative oncology group performance status",
|
| 3841 |
+
"eastern cooperative oncology group performance\nstatus"
|
| 3842 |
],
|
| 3843 |
"orr": [
|
| 3844 |
"is result in a lower overall response\nrate",
|
|
|
|
| 3845 |
"is result in a lower overall response rate",
|
| 3846 |
+
"objective response rate",
|
| 3847 |
"reuss et al\n\n\n\nrate"
|
| 3848 |
],
|
| 3849 |
"pci": [
|
| 3850 |
+
"what is the role of prophylactic cranial irradiation",
|
| 3851 |
+
"prophylactic cranial irradiation"
|
| 3852 |
],
|
| 3853 |
"fda": [
|
|
|
|
| 3854 |
"entrectinib received food and drug administration",
|
| 3855 |
+
"entrectinib received food and\ndrug administration",
|
|
|
|
| 3856 |
"osimertinib is approved by both the united states food and\ndrug administration",
|
| 3857 |
+
"these results led to the food\n\nand drug administration",
|
| 3858 |
+
"food and drug administration",
|
| 3859 |
+
"osimertinib is approved by both the united states food and drug administration",
|
| 3860 |
+
"united states food and drug administration"
|
| 3861 |
],
|
| 3862 |
"crs": [
|
| 3863 |
"cytokine release syndrome"
|
|
|
|
| 3866 |
"department of surgical sciences"
|
| 3867 |
],
|
| 3868 |
"who": [
|
| 3869 |
+
"the recent world health organization",
|
| 3870 |
"world health organization",
|
|
|
|
| 3871 |
"global",
|
| 3872 |
+
"the latest world health organization",
|
| 3873 |
+
"global statistics"
|
| 3874 |
],
|
| 3875 |
"lc": [
|
| 3876 |
+
"these\nguidelines are restricted to lung carcinoid",
|
| 3877 |
+
"these guidelines are restricted to lung carcinoid"
|
| 3878 |
],
|
| 3879 |
"seer": [
|
| 3880 |
+
"end results",
|
| 3881 |
+
"epidemiology and end results"
|
| 3882 |
],
|
| 3883 |
"uicc": [
|
| 3884 |
+
"edition of the union for international cancer control",
|
| 3885 |
"edition of the union for\ninternational cancer control",
|
| 3886 |
+
"union for\ninternational cancer control",
|
| 3887 |
"union for international cancer control",
|
| 3888 |
+
"union for international\ncancer control"
|
|
|
|
|
|
|
| 3889 |
],
|
| 3890 |
"gep": [
|
| 3891 |
+
"based on approval and recommendations in gastroenteropancreatic",
|
| 3892 |
+
"based on\napproval and recommendations in gastroenteropancreatic"
|
| 3893 |
],
|
| 3894 |
"pth": [
|
| 3895 |
"annals of oncology\n\n\n\nparathyroid hormone"
|
| 3896 |
],
|
| 3897 |
"rfa": [
|
| 3898 |
+
"for these patients radiofrequency ablation",
|
| 3899 |
"palliative surgery\nor radiofrequency ablation",
|
| 3900 |
+
"palliative surgery or radiofrequency ablation"
|
|
|
|
| 3901 |
],
|
| 3902 |
"recist": [
|
| 3903 |
"cs with response evaluation criteria in solid tumours",
|
| 3904 |
+
"cs with response evaluation criteria\nin solid tumours",
|
| 3905 |
"measurements and response assessment should follow response evaluation criteria in solid tumours",
|
| 3906 |
+
"measurements and response assessment should follow\nresponse evaluation criteria in solid tumours"
|
| 3907 |
],
|
| 3908 |
"gemox": [
|
| 3909 |
"oxaliplatin combined with gemcitabine"
|
|
|
|
| 3912 |
"lanreotide autogel"
|
| 3913 |
],
|
| 3914 |
"chuv": [
|
| 3915 |
+
"centre hospitalier universitaire\nvaudois",
|
| 3916 |
+
"centre hospitalier universitaire vaudois"
|
| 3917 |
],
|
| 3918 |
"nlst": [
|
| 3919 |
"the much larger national lung cancer screening trial",
|
|
|
|
| 3964 |
"the thoracic surgery scoring\nsystem"
|
| 3965 |
],
|
| 3966 |
"pulmonology": [
|
| 3967 |
+
"respiratory oncology",
|
| 3968 |
+
"respiratory oncology unit"
|
| 3969 |
],
|
| 3970 |
"acs": [
|
| 3971 |
+
"lung cancer screening guidelines published by the\namerican cancer society",
|
| 3972 |
+
"lung cancer screening guidelines published by the american cancer society"
|
| 3973 |
],
|
| 3974 |
"ialt": [
|
| 3975 |
"some trials"
|
|
|
|
| 3978 |
"adjuvant navelbine international trialist association"
|
| 3979 |
],
|
| 3980 |
"sabr": [
|
| 3981 |
+
"consolidative stereotactic ablative radiotherapy",
|
| 3982 |
"what are the indications and recommendations for salvage surgery after stereotactic ablative radiotherapy",
|
|
|
|
| 3983 |
"what are the outcomes comparing stereotactic ablative radiotherapy",
|
| 3984 |
+
"radiographic changes after lung stereotactic ablative radiotherapy",
|
| 3985 |
+
"radiographic changes after lung stereotactic\nablative radiotherapy"
|
| 3986 |
],
|
| 3987 |
"vumc": [
|
| 3988 |
"vrije\nuniversity medical centre",
|
|
|
|
| 3993 |
"bemeneed"
|
| 3994 |
],
|
| 3995 |
"bms": [
|
| 3996 |
+
"bristol myers squibb",
|
| 3997 |
"myers\nsquibb",
|
| 3998 |
+
"myers squibb",
|
| 3999 |
"bristol myers\nsquibb",
|
| 4000 |
+
"bristol\nmyers squibb"
|
|
|
|
|
|
|
| 4001 |
],
|
| 4002 |
"msd": [
|
| 4003 |
"dohme"
|
| 4004 |
],
|
| 4005 |
"eortc": [
|
|
|
|
| 4006 |
"chair of the european\norganisation for research and treatment of cancer",
|
| 4007 |
+
"european\norganisation for research and treatment of cancer",
|
| 4008 |
"treatment of cancer",
|
| 4009 |
+
"european organisation for research and treatment of cancer",
|
| 4010 |
+
"chair of the european organisation for research and treatment of cancer"
|
| 4011 |
],
|
| 4012 |
"cpg": [
|
| 4013 |
"clinical practice guideline"
|
| 4014 |
],
|
| 4015 |
"escat": [
|
| 4016 |
"scale for clinical actionability of\nmolecular targets",
|
| 4017 |
+
"targets",
|
| 4018 |
+
"scale for clinical actionability of molecular targets"
|
| 4019 |
],
|
| 4020 |
"alk": [
|
| 4021 |
"positive anaplastic lymphoma kinase"
|
| 4022 |
],
|
| 4023 |
"ish": [
|
| 4024 |
+
"detection is reliable by\nin situ hybridisation",
|
| 4025 |
+
"detection is reliable by in situ hybridisation"
|
| 4026 |
],
|
| 4027 |
"cns": [
|
| 4028 |
"imaging of the central nervous system"
|
|
|
|
| 4041 |
"interstitial lung disease"
|
| 4042 |
],
|
| 4043 |
"kras": [
|
| 4044 |
+
"the\nkirsten rat sarcoma virus",
|
| 4045 |
+
"the kirsten rat sarcoma virus"
|
| 4046 |
],
|
| 4047 |
"lat": [
|
| 4048 |
"data regarding the role of local ablative therapy"
|
|
|
|
| 4058 |
"lung cancer group and past secretary and current\nchair of the nederlandse vereniging van artsen voor longziekten en tuberculose"
|
| 4059 |
],
|
| 4060 |
"atorg": [
|
| 4061 |
+
"asian thoracic oncology research group",
|
| 4062 |
+
"asian\nthoracic oncology research group"
|
| 4063 |
],
|
| 4064 |
"clcrf": [
|
| 4065 |
"chinese lung\ncancer research foundation limited",
|
| 4066 |
"chinese lung cancer research foundation limited"
|
| 4067 |
],
|
| 4068 |
"csco": [
|
|
|
|
| 4069 |
"chinese society of clinical oncology",
|
| 4070 |
+
"china",
|
| 4071 |
+
"chinese\nsociety of clinical oncology"
|
| 4072 |
],
|
| 4073 |
"hkcf": [
|
| 4074 |
"hong kong cancer fund"
|
|
|
|
| 4087 |
"research to practice"
|
| 4088 |
],
|
| 4089 |
"samo": [
|
| 4090 |
+
"president of swiss academy of multidisciplinary oncology",
|
| 4091 |
+
"president of swiss\nacademy of multidisciplinary oncology"
|
| 4092 |
],
|
| 4093 |
"sakk": [
|
| 4094 |
"research",
|
| 4095 |
+
"president of lung group for swiss group for clinical cancer research",
|
| 4096 |
+
"president of lung group for swiss group for clinical cancer\nresearch"
|
| 4097 |
],
|
| 4098 |
"etop": [
|
| 4099 |
"european thoracic oncology platform"
|
|
|
|
| 4102 |
"international breast cancer study group"
|
| 4103 |
],
|
| 4104 |
"aacr": [
|
| 4105 |
+
"partners member\nof american association of cancer research",
|
| 4106 |
+
"partners member of american association of cancer research"
|
| 4107 |
],
|
| 4108 |
"asmac": [
|
| 4109 |
"clinique"
|
|
|
|
| 4113 |
],
|
| 4114 |
"chmp": [
|
| 4115 |
"summary of opinion",
|
| 4116 |
+
"products for human use",
|
| 4117 |
+
"committee for medicinal products for human use"
|
| 4118 |
],
|
| 4119 |
"paga": [
|
| 4120 |
"asian adapted"
|
| 4121 |
],
|
| 4122 |
"ishmo": [
|
|
|
|
| 4123 |
"indonesian society\nof hematology and medical oncology",
|
| 4124 |
+
"indonesian society of hematology and medical oncology",
|
| 4125 |
+
"indonesia"
|
| 4126 |
],
|
| 4127 |
"jsmo": [
|
| 4128 |
+
"japan",
|
| 4129 |
+
"japanese society of medical oncology"
|
| 4130 |
],
|
| 4131 |
"ksmo": [
|
| 4132 |
"korea",
|
|
|
|
| 4137 |
"malaysia"
|
| 4138 |
],
|
| 4139 |
"psmo": [
|
|
|
|
|
|
|
| 4140 |
"philippines",
|
| 4141 |
+
"philippine society of medical\noncology",
|
| 4142 |
+
"philippine society of\nmedical oncology",
|
| 4143 |
"philippine society of medical oncology"
|
| 4144 |
],
|
| 4145 |
"sso": [
|
|
|
|
| 4148 |
"singapore"
|
| 4149 |
],
|
| 4150 |
"tos": [
|
| 4151 |
+
"taiwan",
|
| 4152 |
+
"taiwan oncology society"
|
| 4153 |
],
|
| 4154 |
"tsco": [
|
| 4155 |
"thai society of clinical oncology",
|
|
|
|
| 4163 |
"national medical products\nadministration"
|
| 4164 |
],
|
| 4165 |
"nmpa": [
|
| 4166 |
+
"chinese national\nmedical products administration",
|
| 4167 |
+
"chinese national medical products administration"
|
| 4168 |
],
|
| 4169 |
"jkn": [
|
| 4170 |
"the jaminan kesehatan nasional"
|
| 4171 |
],
|
| 4172 |
"fornas": [
|
|
|
|
| 4173 |
"national standard of medication list",
|
| 4174 |
"national standard of\nmedication list",
|
| 4175 |
+
"national drug formulary",
|
| 4176 |
+
"na\ntional drug formulary"
|
| 4177 |
],
|
| 4178 |
"pap": [
|
| 4179 |
"open\n\n\n\nprogram"
|
| 4180 |
],
|
| 4181 |
"pdma": [
|
| 4182 |
+
"it may take from several months to years for the pharmaceuticals and medical devices agency",
|
| 4183 |
+
"it may take\nfrom several months to years for the pharmaceuticals and\nmedical devices agency"
|
| 4184 |
],
|
| 4185 |
"nhi": [
|
| 4186 |
"national health insurance"
|
| 4187 |
],
|
| 4188 |
"torg": [
|
| 4189 |
+
"thoracic oncology research\ngroup",
|
| 4190 |
+
"thoracic oncology research group"
|
| 4191 |
],
|
| 4192 |
"wjog": [
|
| 4193 |
"west japan oncology group"
|
|
|
|
| 4196 |
"trial steering committee"
|
| 4197 |
],
|
| 4198 |
"idmc": [
|
| 4199 |
+
"independent data monitoring committee",
|
| 4200 |
+
"committee"
|
| 4201 |
],
|
| 4202 |
"ukiog": [
|
| 4203 |
"ireland oesophagogastric group"
|
|
|
|
| 4295 |
"diffuse idiopathic pulmonary neuroendocrine cell hyperplasia"
|
| 4296 |
],
|
| 4297 |
"port": [
|
|
|
|
|
|
|
| 4298 |
"what is the current evidence and recommendation for postoperative radiotherapy",
|
| 4299 |
+
"postoperative radiotherapy",
|
| 4300 |
+
"what are the outcomes and recommendations for postoperative radiotherapy",
|
| 4301 |
+
"radiotherapy"
|
| 4302 |
],
|
| 4303 |
"i-v": [
|
| 4304 |
"classification system showing five levels of evidence"
|
logs/app.log
CHANGED
|
@@ -9262,3 +9262,66 @@ ImportError: cannot import name 'store_user_question' from 'core.tools' (d:\Work
|
|
| 9262 |
2025-11-16 14:31:54,318 - AgenticMedicalRAG - INFO - LLM initialized successfully
|
| 9263 |
2025-11-16 14:31:54,319 - AgenticMedicalRAG - INFO - π Background Init: All components initialized successfully (100%)
|
| 9264 |
2025-11-16 14:31:54,319 - AgenticMedicalRAG - INFO - β
Background initialization completed successfully
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| 9262 |
2025-11-16 14:31:54,318 - AgenticMedicalRAG - INFO - LLM initialized successfully
|
| 9263 |
2025-11-16 14:31:54,319 - AgenticMedicalRAG - INFO - π Background Init: All components initialized successfully (100%)
|
| 9264 |
2025-11-16 14:31:54,319 - AgenticMedicalRAG - INFO - β
Background initialization completed successfully
|
| 9265 |
+
2025-11-17 18:58:17,162 - AgenticMedicalRAG - INFO - Configuration validation completed
|
| 9266 |
+
2025-11-17 18:58:18,680 - AgenticMedicalRAG - INFO - Loaded 1085 learned synonyms from cache
|
| 9267 |
+
2025-11-17 18:58:19,132 - AgenticMedicalRAG - INFO - π Starting background initialization...
|
| 9268 |
+
2025-11-17 18:58:19,133 - AgenticMedicalRAG - INFO - π Background Init: Starting background initialization... (0%)
|
| 9269 |
+
2025-11-17 18:58:19,134 - AgenticMedicalRAG - INFO - π Background Init: Loading embedding model... (10%)
|
| 9270 |
+
2025-11-17 18:58:19,134 - AgenticMedicalRAG - INFO - Loading embedding model (first time)...
|
| 9271 |
+
2025-11-17 18:58:26,904 - AgenticMedicalRAG - INFO - Embedding model loaded successfully
|
| 9272 |
+
2025-11-17 18:58:26,905 - AgenticMedicalRAG - INFO - π Background Init: Embedding model loaded successfully (40%)
|
| 9273 |
+
2025-11-17 18:58:26,905 - AgenticMedicalRAG - INFO - π Background Init: Initializing retrievers and loading chunks... (50%)
|
| 9274 |
+
2025-11-17 18:58:26,905 - AgenticMedicalRAG - INFO - π Initializing retrievers (first time use)...
|
| 9275 |
+
2025-11-17 18:58:26,905 - AgenticMedicalRAG - INFO - π Processing new data and updating vector store if needed...
|
| 9276 |
+
2025-11-17 18:58:27,057 - AgenticMedicalRAG - INFO - π¦ Loading chunks cache for BM25 retriever...
|
| 9277 |
+
2025-11-17 18:58:27,094 - AgenticMedicalRAG - INFO - π Creating vector retriever...
|
| 9278 |
+
2025-11-17 18:58:27,095 - AgenticMedicalRAG - INFO - π Creating BM25 retriever...
|
| 9279 |
+
2025-11-17 18:58:27,964 - AgenticMedicalRAG - INFO - π Creating hybrid retriever...
|
| 9280 |
+
2025-11-17 18:58:27,964 - AgenticMedicalRAG - INFO - β
Retrievers initialized successfully.
|
| 9281 |
+
2025-11-17 18:58:27,964 - AgenticMedicalRAG - INFO - π Background Init: Retrievers initialized successfully (90%)
|
| 9282 |
+
2025-11-17 18:58:27,965 - AgenticMedicalRAG - INFO - π Background Init: Learning medical terminology from corpus... (92%)
|
| 9283 |
+
2025-11-17 18:58:31,275 - AgenticMedicalRAG - INFO - Saved learned terms to cache
|
| 9284 |
+
2025-11-17 18:58:31,276 - AgenticMedicalRAG - INFO - Learned medical terminology from 1000 documents
|
| 9285 |
+
2025-11-17 18:58:31,276 - AgenticMedicalRAG - INFO - π Background Init: Warming up LLM... (97%)
|
| 9286 |
+
2025-11-17 18:58:31,276 - AgenticMedicalRAG - INFO - Initializing LLM (first time)...
|
| 9287 |
+
2025-11-17 18:58:32,024 - AgenticMedicalRAG - INFO - LLM initialized successfully
|
| 9288 |
+
2025-11-17 18:58:32,025 - AgenticMedicalRAG - INFO - π Background Init: All components initialized successfully (100%)
|
| 9289 |
+
2025-11-17 18:58:32,025 - AgenticMedicalRAG - INFO - β
Background initialization completed successfully
|
| 9290 |
+
2025-11-17 18:59:13,558 - AgenticMedicalRAG - INFO - Processing user input (attempt 1): Give me the options for first line treatment for N...
|
| 9291 |
+
2025-11-17 18:59:15,953 - AgenticMedicalRAG - INFO - No specific provider - querying each provider separately for balanced results
|
| 9292 |
+
2025-11-17 18:59:15,953 - AgenticMedicalRAG - INFO - Querying provider: ASCO
|
| 9293 |
+
2025-11-17 18:59:16,579 - AgenticMedicalRAG - INFO - Hybrid search returned 1 unique documents (query expansion: False)
|
| 9294 |
+
2025-11-17 18:59:16,618 - AgenticMedicalRAG - INFO - Enriched 1 documents with surrounding context pages
|
| 9295 |
+
2025-11-17 18:59:16,619 - AgenticMedicalRAG - INFO - Retrieved 1 documents from ASCO
|
| 9296 |
+
2025-11-17 18:59:16,619 - AgenticMedicalRAG - INFO - Querying provider: ESMO
|
| 9297 |
+
2025-11-17 18:59:16,693 - AgenticMedicalRAG - INFO - Hybrid search returned 6 unique documents (query expansion: False)
|
| 9298 |
+
2025-11-17 18:59:16,696 - AgenticMedicalRAG - INFO - Enriched 1 documents with surrounding context pages
|
| 9299 |
+
2025-11-17 18:59:16,697 - AgenticMedicalRAG - INFO - Retrieved 6 documents from ESMO
|
| 9300 |
+
2025-11-17 18:59:16,697 - AgenticMedicalRAG - INFO - Querying provider: IASLC
|
| 9301 |
+
2025-11-17 18:59:16,769 - AgenticMedicalRAG - INFO - Hybrid search returned 0 unique documents (query expansion: False)
|
| 9302 |
+
2025-11-17 18:59:16,769 - AgenticMedicalRAG - INFO - Querying provider: NCCN
|
| 9303 |
+
2025-11-17 18:59:16,842 - AgenticMedicalRAG - INFO - Hybrid search returned 0 unique documents (query expansion: False)
|
| 9304 |
+
2025-11-17 18:59:16,842 - AgenticMedicalRAG - INFO - Querying provider: NICE
|
| 9305 |
+
2025-11-17 18:59:16,912 - AgenticMedicalRAG - INFO - Hybrid search returned 5 unique documents (query expansion: False)
|
| 9306 |
+
2025-11-17 18:59:16,915 - AgenticMedicalRAG - INFO - Enriched 1 documents with surrounding context pages
|
| 9307 |
+
2025-11-17 18:59:16,916 - AgenticMedicalRAG - INFO - Retrieved 5 documents from NICE
|
| 9308 |
+
2025-11-17 18:59:38,154 - AgenticMedicalRAG - INFO - Successfully processed user input: Give me the options for first line treatment for N...
|
| 9309 |
+
2025-11-17 18:59:38,154 - AgenticMedicalRAG - INFO - Performing background validation...
|
| 9310 |
+
2025-11-17 18:59:39,069 - AgenticMedicalRAG - INFO - Medical answer validator initialized successfully
|
| 9311 |
+
2025-11-17 18:59:39,069 - AgenticMedicalRAG - INFO - GitHub token configured: ghp_KWH...dnCc
|
| 9312 |
+
2025-11-17 18:59:39,069 - AgenticMedicalRAG - INFO - GitHub storage initialized for MoazEldsouky/cloud-data-store
|
| 9313 |
+
2025-11-17 18:59:40,033 - AgenticMedicalRAG - INFO - Found 23 existing evaluations in GitHub
|
| 9314 |
+
2025-11-17 18:59:40,033 - AgenticMedicalRAG - INFO - Next interaction ID will be: 24
|
| 9315 |
+
2025-11-17 18:59:40,034 - AgenticMedicalRAG - INFO - Starting validation for interaction 24
|
| 9316 |
+
2025-11-17 19:00:00,170 - AgenticMedicalRAG - INFO - Attempting to save evaluation with ID: 24
|
| 9317 |
+
2025-11-17 19:00:00,170 - AgenticMedicalRAG - INFO - GitHub storage instance obtained, calling save_validation_results...
|
| 9318 |
+
2025-11-17 19:00:00,171 - AgenticMedicalRAG - INFO - Attempt 1/3: Loading existing evaluations from GitHub...
|
| 9319 |
+
2025-11-17 19:00:02,914 - AgenticMedicalRAG - INFO - Successfully loaded 23 existing evaluations
|
| 9320 |
+
2025-11-17 19:00:02,915 - AgenticMedicalRAG - INFO - Adding new evaluation with ID: 24
|
| 9321 |
+
2025-11-17 19:00:02,915 - AgenticMedicalRAG - INFO - Appended new evaluation. Total count: 24
|
| 9322 |
+
2025-11-17 19:00:03,938 - AgenticMedicalRAG - INFO - Uploading to GitHub: medical_data/evaluation_results.json (size: 879332 bytes)
|
| 9323 |
+
2025-11-17 19:00:08,498 - AgenticMedicalRAG - INFO - β Successfully uploaded medical_data/evaluation_results.json to GitHub
|
| 9324 |
+
2025-11-17 19:00:08,500 - AgenticMedicalRAG - INFO - β Successfully saved evaluation 24. Total evaluations now: 24
|
| 9325 |
+
2025-11-17 19:00:08,501 - AgenticMedicalRAG - INFO - β Evaluation saved to GitHub successfully with ID: 24
|
| 9326 |
+
2025-11-17 19:00:08,502 - AgenticMedicalRAG - INFO - Background validation completed - Interaction ID: 24
|
| 9327 |
+
2025-11-17 19:00:08,502 - AgenticMedicalRAG - INFO - Validation scores - Overall: 90/100, Accuracy: 95/100, Coherence: 90/100, Relevance: 88/100
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