---
title: Regulatory Variant Effect
emoji: 🧬
colorFrom: pink
colorTo: red
sdk: gradio
sdk_version: 6.14.0
python_version: "3.13"
app_file: app.py
pinned: false
license: agpl-3.0
suggested_hardware: t4-small
models:
  - multimolecule/a2zchromatin
  - multimolecule/basset
  - multimolecule/deepmel
  - multimolecule/deepsea
  - multimolecule/deepstarr
  - multimolecule/malinois
  - multimolecule/mpradragonn
  - multimolecule/scbasset
  - multimolecule/xpresso
tags:
  - biology
  - dna
  - regulatory-genomics
  - variant-effect
  - multimolecule
---

Interactive regulatory variant-effect scoring with MultiMolecule.

Enter matched reference and alternative DNA sequences, choose a regulatory variant-effect checkpoint, and inspect the alternative-minus-reference delta table. Sequence-level reference and alternative scores are included when the pipeline returns them. Results can be downloaded as CSV or JSON.

This Space intentionally scores only user-provided sequence windows. It does not perform genome-coordinate lookup, reference-genome retrieval, transcript mapping, or variant normalization.