---
title: Splice Variant Effect
emoji: 🧬
colorFrom: purple
colorTo: pink
sdk: gradio
sdk_version: 6.14.0
python_version: "3.13"
app_file: app.py
pinned: false
license: agpl-3.0
suggested_hardware: t4-small
models:
  - multimolecule/mmsplice
  - multimolecule/mtsplice
  - multimolecule/hal
  - multimolecule/maxentscan-score5
  - multimolecule/maxentscan-score3
  - multimolecule/pangolin
  - multimolecule/sptransformer
tags:
  - biology
  - dna
  - splicing
  - variant-effect
  - multimolecule
---

Interactive splice variant-effect scoring with MultiMolecule.

Enter same-length reference and alternative DNA sequence windows, or upload a two-record FASTA file with the reference first and the alternative second. The app runs the Transformers `splice-variant-effect` pipeline registered by MultiMolecule and reports delta scores, optional reference and alternative scores, run metadata, and downloadable CSV/JSON outputs.

This Space intentionally works on supplied sequence windows only. It does not perform genome-coordinate lookup, transcript annotation, or reference sequence reconstruction.