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title: Nirschl Lab for Computational Neuropathology
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# Computational Neuropathology Lab

**University of Wisconsin–Madison**

We develop artificial intelligence and machine-learning methods for computational neuropathology. Our research integrates digital histopathology, whole-slide imaging, spatial transcriptomics, and multimodal data to improve disease quantification, biomarker discovery, and understanding of Alzheimer’s disease and related neurodegenerative disorders.

## Research areas

* Computational and digital neuropathology
* Deep learning for whole-slide image analysis
* Spatial transcriptomics and multimodal data integration
* Interpretable AI and quantitative tissue phenotyping
* Alzheimer’s disease, Lewy body disease, and related dementias

## Open science

We share models, datasets, and open-source tools that support transparent, reproducible biomedical research. Please consult each repository for documentation, licensing, intended use, and limitations.

## Principal investigator

**Jeffrey Nirschl, MD, PhD**
Physician-scientist and neuropathologist
Assistant Professor of Pathology, University of Wisconsin–Madison

* [Lab website](https://nirschl-lab.github.io/nirschl-lab-website/)
* [Jeffrey Nirschl’s ORCID](https://orcid.org/0000-0001-6857-341X)