sample_data/patents_sample.json

[
  {
    "title": "Method for producing neutralizing antibodies",
    "authors": ["Inventor A"],
    "source": "Patent",
    "url": "https://patents.example/US123456",
    "abstract": "A process that provides methods to generate monoclonal neutralizing antibodies using engineered cell lines.",
    "text": "A method for producing neutralizing antibodies using engineered cell lines. The method includes screening steps and optimization of Fc variants."
  },
  {
    "title": "Targeting CD19 with Chimeric Antigen Receptor T Cells for B-cell Malignancies",
    "authors": ["Chen B", "Wang D"],
    "source": "Patent",
    "url": "https://patents.example/EP300100",
    "abstract": "The invention relates to genetically modified T cells expressing a Chimeric Antigen Receptor (CAR) specific for the CD19 antigen, and their use in treating leukemia and lymphoma.",
    "text": "Compositions and methods for adoptive T cell therapy using CAR-T cells directed against CD19. Includes a specific scFv sequence and co-stimulatory domains (4-1BB and CD3$\zeta$). The final drug product composition is also claimed."
  },
  {
    "title": "Hydrogel-based Drug Delivery System for Sustained Release of Insulin",
    "authors": ["Patel S", "Smith J"],
    "source": "Patent",
    "url": "https://patents.example/WO20230500",
    "abstract": "A biocompatible, injectable hydrogel composition for the subcutaneous delivery of therapeutic agents, specifically insulin, over a period of at least seven days.",
    "text": "A cross-linked poly(ethylene glycol) (PEG) based hydrogel matrix containing encapsulated insulin microparticles. The invention covers the specific polymer ratio and $\mathrm{pH}$-sensitive degradation profile allowing zero-order release kinetics for sustained diabetes management."
  },
  {
    "title": "Non-Invasive Sensor and Algorithm for Continuous Blood Pressure Monitoring",
    "authors": ["Lee H", "Kim Y"],
    "source": "Patent",
    "url": "https://patents.example/US11223344",
    "abstract": "A wearable medical device and accompanying algorithm for cuffless, continuous measurement of arterial blood pressure using Photoplethysmography (PPG) and Electrocardiography (ECG) sensors.",
    "text": "A wrist-worn medical device incorporating PPG and ECG sensors to calculate Pulse Wave Velocity (PWV). The claim details a machine learning model trained on over 1,000 patient datasets to calibrate and provide accurate blood pressure readings within $5\ \mathrm{mmHg}$ of invasive measurements."
  },
  {
    "title": "Novel Small Molecule Inhibitor of FGFR1 for Cancer Treatment",
    "authors": ["Garcia R"],
    "source": "Patent",
    "url": "https://patents.example/JP6000100",
    "abstract": "Compounds, compositions, and methods for treating solid tumors characterized by overexpression or mutation of Fibroblast Growth Factor Receptor 1 (FGFR1) kinase.",
    "text": "Compound G-25, a selective FGFR1 inhibitor with a specific chemical structure (detailed in Claim 1), and its pharmaceutically acceptable salts. The patent claims include its use in treating bladder cancer and lung cancer, and its synthesis pathway."
  },
  {
    "title": "Automated System for High-Throughput DNA Sequencing Using Nanopores",
    "authors": ["Miller A", "Singh P"],
    "source": "Patent",
    "url": "https://patents.example/GB2550999",
    "abstract": "An apparatus and method for rapidly and accurately determining the base sequence of a nucleic acid molecule by passing it through an engineered protein nanopore and detecting characteristic current changes.",
    "text": "A nanopore sequencing device architecture that includes an array of $1,024$ individually addressable nanopore channels. The patent claims an improved method of signal processing (a Hidden Markov Model) for base calling with Q scores greater than Q30 for $90\%$ of reads."
  },
  {
    "title": "RNA Vaccine Encoding Stabilized Spike Protein and Delivery System",
    "authors": ["Dubois G", "Kaur M"],
    "source": "Patent",
    "url": "https://patents.example/CA3100000",
    "abstract": "A lipid nanoparticle ($\mathrm{LNP}$) composition encapsulating a messenger RNA ($\mathrm{mRNA}$) that encodes a prefusion-stabilized viral Spike ($\mathrm{S}$) protein for use as a vaccine.",
    "text": "An mRNA vaccine composition comprising a sequence that includes two proline substitutions at positions K986 and V987 to stabilize the S protein. The LNP formulation includes specific cationic lipids (ALC-0315) and is optimized for storage at $-20^\circ\mathrm{C}$."
  },
  {
    "title": "Smart Surgical Stapler with Tissue Thickness Sensing",
    "authors": ["Nguyen T", "White C"],
    "source": "Patent",
    "url": "https://patents.example/US10500000",
    "abstract": "A surgical stapling device with integrated sensors to measure tissue thickness and automatically adjust staple height and forming force prior to and during the firing sequence.",
    "text": "A motorized surgical stapler head equipped with capacitance sensors at the anvil and cartridge jaws. The system calculates Tissue Compression Ratio (TCR) and selects the optimal staple cartridge (e.g., green, gold, blue) from an internal lookup table, reducing the risk of anastomotic leaks."
  },
  {
    "title": "Use of Extracellular Vesicles for Neuroregenerative Therapy",
    "authors": ["Takahashi Y", "Choi S"],
    "source": "Patent",
    "url": "https://patents.example/AU202410100",
    "abstract": "The application claims methods of treating neurodegenerative diseases, such as Parkinson's disease, by administering Exosomes derived from mesenchymal stem cells (MSCs).",
    "text": "A therapeutic composition comprising Exosomes isolated from induced pluripotent stem cell-derived MSCs (iPSC-MSCs) that are modified to overexpress BDNF (Brain-Derived Neurotrophic Factor). The patent claims methods of intravenous delivery to target the Dopaminergic neurons."
  },
  {
    "title": "Bio-Resorbable Coronary Stent Made of Magnesium Alloy",
    "authors": ["Wong L", "Martinez P"],
    "source": "Patent",
    "url": "https://patents.example/EP4550000",
    "abstract": "A fully bio-resorbable vascular scaffold (BVS) for the treatment of coronary artery disease, fabricated from a proprietary magnesium-neodymium alloy with adjustable degradation kinetics.",
    "text": "A stent design featuring a specific open-cell geometry to maintain vessel support for six months while ensuring complete resorption within 18 months, thereby eliminating long-term foreign body presence. The alloy composition includes $94\%\ \mathrm{Mg}$ and $6\%\ \mathrm{Nd}$ for optimal mechanical properties and bio-compatibility."
  }
]