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Update sample_data/pubmed_sample.json
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sample_data/pubmed_sample.json
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@@ -50,26 +50,26 @@
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"doi": "10.1200/medtech.cgm.20",
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"source": "Diabetes Care",
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"url": "https://diabetescare.example/12",
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| 53 |
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"abstract": "A 12-week prospective study (n=150) assessed the impact of a new minimally invasive continuous glucose monitor (CGM) on
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"text": "A 12-week prospective study (n=150) assessed the impact of a new minimally invasive continuous glucose monitor (CGM) on $\mathrm{HbA1c}$ levels. Mean $\mathrm{HbA1c}$ reduction was $0.8\%$, significantly greater than the control group. Patient satisfaction was high. Methods: RCT, $\mathrm{HbA1c}$ measurement, Statistical analysis."
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},
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{
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"title": "Targeting the
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"authors": ["Jones M", "Kumar R"],
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"doi": "10.1300/pharma.p38.25",
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"source": "Journal of Medicinal Chemistry",
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"url": "https://jmedchem.example/13",
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"abstract": "We designed and synthesized a series of novel small-molecule inhibitors targeting the
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"text": "We designed and synthesized a series of novel small-molecule inhibitors targeting the $\mathrm{P38}$ $\mathrm{MAPK}$ pathway. Compound $\mathrm{JMK}-21$ demonstrated the highest potency ($\mathrm{IC}_{50} = 5\ \mathrm{nM}$) and selectivity in *in vitro* assays. Efficacy shown in a mouse arthritis model. Methods: $\mathrm{IC}_{50}$ assay, $\mathrm{HPLC}$, Animal model."
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},
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{
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"title": "Cryo-EM Structure of the Human
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"authors": ["Sato T", "Gao L"],
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"doi": "10.1400/biotech.cryo.17",
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"source": "Cell",
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"url": "https://cell.example/14",
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"abstract": "The high-resolution ($2.5\ \mathrm{\AA}$) cryo-electron microscopy (Cryo-EM) structure of the $\mathrm{GABA}_\mathrm{A}$ receptor was determined in complex with the benzodiazepine, diazepam. The structure reveals the precise binding site and conformational changes induced upon ligand binding. Implications for drug design discussed. Methods: Cryo-EM, Single-particle analysis.",
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"text": "The high-resolution ($2.5\ \mathrm{\AA}$) cryo-electron microscopy (Cryo-EM) structure of the $\mathrm{GABA}_\mathrm{A}$ receptor was determined in complex with the benzodiazepine, diazepam. The structure reveals the precise binding site and conformational changes induced upon ligand binding. Implications for drug design discussed. Methods: Cryo-EM, Single-particle analysis."
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},
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{
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"title": "Effectiveness of a Robotic Surgical System for Minimally Invasive Prostatectomy",
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@@ -81,12 +81,12 @@
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"text": "A retrospective cohort study comparing 500 robotic-assisted vs. 500 open prostatectomy procedures found significantly lower blood loss and shorter hospital stay in the robotic group. No difference in long-term oncological outcomes. Med device implications are clear. Methods: Retrospective Cohort, Propensity Score Matching."
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| 82 |
},
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{
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"title": "CRISPR-Mediated Gene Editing for Correction of the
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"authors": ["Zhang Q", "Doudna J"],
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"doi": "10.1600/biotech.crispr.05",
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"source": "Science",
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"url": "https://science.example/16",
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"abstract": "We used an
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"text": "We used an $\mathrm{AAV}$-delivered $\mathrm{CRISPR}$-$\mathrm{Cas9}$ system to correct the $\Delta\mathrm{F508}$ mutation in cystic fibrosis transmembrane conductance regulator ($\mathrm{CFTR}$) in primary human bronchial epithelial cells. Correction efficiency reached $40\%$ and restored chloride channel function. Methods: $\mathrm{CRISPR/Cas9}$, $\mathrm{AAV}$ delivery, Patch-clamp electrophysiology."
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}
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]
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"doi": "10.1200/medtech.cgm.20",
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"source": "Diabetes Care",
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"url": "https://diabetescare.example/12",
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| 53 |
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"abstract": "A 12-week prospective study (n=150) assessed the impact of a new minimally invasive continuous glucose monitor (CGM) on HbA1c levels. Mean HbA1c reduction was $0.8\%$, significantly greater than the control group. Patient satisfaction was high. Methods: RCT, HbA1c measurement, Statistical analysis.",
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"text": "A 12-week prospective study (n=150) assessed the impact of a new minimally invasive continuous glucose monitor (CGM) on $\mathrm{HbA1c}$ levels. Mean $\mathrm{HbA1c}$ reduction was $0.8\%$, significantly greater than the control group. Patient satisfaction was high. Methods: RCT, $\mathrm{HbA1c}$ measurement, Statistical analysis."
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},
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| 56 |
{
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"title": "Targeting the P38 MAPK Pathway for Novel Anti-inflammatory Drug Development",
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"authors": ["Jones M", "Kumar R"],
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"doi": "10.1300/pharma.p38.25",
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"source": "Journal of Medicinal Chemistry",
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"url": "https://jmedchem.example/13",
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| 62 |
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"abstract": "We designed and synthesized a series of novel small-molecule inhibitors targeting the P38 MAPK pathway. Compound JMK-21 demonstrated the highest potency ($\mathrm{IC}_{50} = 5\ \mathrm{nM}$) and selectivity in *in vitro* assays. Efficacy shown in a mouse arthritis model. Methods: $\mathrm{IC}_{50}$ assay, $\mathrm{HPLC}$, Animal model.",
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"text": "We designed and synthesized a series of novel small-molecule inhibitors targeting the $\mathrm{P38}$ $\mathrm{MAPK}$ pathway. Compound $\mathrm{JMK}-21$ demonstrated the highest potency ($\mathrm{IC}_{50} = 5\ \mathrm{nM}$) and selectivity in *in vitro* assays. Efficacy shown in a mouse arthritis model. Methods: $\mathrm{IC}_{50}$ assay, $\mathrm{HPLC}$, Animal model."
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},
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{
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"title": "Cryo-EM Structure of the Human GABAA Receptor Bound to Diazepam",
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"authors": ["Sato T", "Gao L"],
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"doi": "10.1400/biotech.cryo.17",
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"source": "Cell",
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"url": "https://cell.example/14",
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"abstract": "The high-resolution ($2.5\ \mathrm{\AA}$) cryo-electron microscopy ($\mathrm{Cryo}$-$\mathrm{EM}$) structure of the $\mathrm{GABA}_{\mathrm{A}}$ receptor was determined in complex with the benzodiazepine, diazepam. The structure reveals the precise binding site and conformational changes induced upon ligand binding. Implications for drug design discussed. Methods: $\mathrm{Cryo}$-$\mathrm{EM}$, Single-particle analysis.",
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| 72 |
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"text": "The high-resolution ($2.5\ \mathrm{\AA}$) cryo-electron microscopy ($\mathrm{Cryo}$-$\mathrm{EM}$) structure of the $\mathrm{GABA}_{\mathrm{A}}$ receptor was determined in complex with the benzodiazepine, diazepam. The structure reveals the precise binding site and conformational changes induced upon ligand binding. Implications for drug design discussed. Methods: $\mathrm{Cryo}$-$\mathrm{EM}$, Single-particle analysis."
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},
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{
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"title": "Effectiveness of a Robotic Surgical System for Minimally Invasive Prostatectomy",
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"text": "A retrospective cohort study comparing 500 robotic-assisted vs. 500 open prostatectomy procedures found significantly lower blood loss and shorter hospital stay in the robotic group. No difference in long-term oncological outcomes. Med device implications are clear. Methods: Retrospective Cohort, Propensity Score Matching."
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| 82 |
},
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| 83 |
{
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| 84 |
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"title": "CRISPR-Mediated Gene Editing for Correction of the CFTR Mutation in Primary Airway Cells",
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"authors": ["Zhang Q", "Doudna J"],
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| 86 |
"doi": "10.1600/biotech.crispr.05",
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"source": "Science",
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| 88 |
"url": "https://science.example/16",
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| 89 |
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"abstract": "We used an AAV-delivered CRISPR-Cas9 system to correct the $\Delta\mathrm{F508}$ mutation in cystic fibrosis transmembrane conductance regulator ($\mathrm{CFTR}$) in primary human bronchial epithelial cells. Correction efficiency reached $40\%$ and restored chloride channel function. Methods: $\mathrm{CRISPR/Cas9}$, $\mathrm{AAV}$ delivery, Patch-clamp electrophysiology.",
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| 90 |
"text": "We used an $\mathrm{AAV}$-delivered $\mathrm{CRISPR}$-$\mathrm{Cas9}$ system to correct the $\Delta\mathrm{F508}$ mutation in cystic fibrosis transmembrane conductance regulator ($\mathrm{CFTR}$) in primary human bronchial epithelial cells. Correction efficiency reached $40\%$ and restored chloride channel function. Methods: $\mathrm{CRISPR/Cas9}$, $\mathrm{AAV}$ delivery, Patch-clamp electrophysiology."
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| 91 |
}
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| 92 |
]
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