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Update sample_data/pubmed_sample.json

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  1. sample_data/pubmed_sample.json +8 -8
sample_data/pubmed_sample.json CHANGED
@@ -50,26 +50,26 @@
50
  "doi": "10.1200/medtech.cgm.20",
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  "source": "Diabetes Care",
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  "url": "https://diabetescare.example/12",
53
- "abstract": "A 12-week prospective study (n=150) assessed the impact of a new minimally invasive continuous glucose monitor (CGM) on $\mathrm{HbA1c}$ levels. Mean $\mathrm{HbA1c}$ reduction was $0.8\%$, significantly greater than the control group. Patient satisfaction was high. Methods: RCT, $\mathrm{HbA1c}$ measurement, Statistical analysis.",
54
  "text": "A 12-week prospective study (n=150) assessed the impact of a new minimally invasive continuous glucose monitor (CGM) on $\mathrm{HbA1c}$ levels. Mean $\mathrm{HbA1c}$ reduction was $0.8\%$, significantly greater than the control group. Patient satisfaction was high. Methods: RCT, $\mathrm{HbA1c}$ measurement, Statistical analysis."
55
  },
56
  {
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- "title": "Targeting the $\mathrm{P38}$ $\mathrm{MAPK}$ Pathway for Novel Anti-inflammatory Drug Development",
58
  "authors": ["Jones M", "Kumar R"],
59
  "doi": "10.1300/pharma.p38.25",
60
  "source": "Journal of Medicinal Chemistry",
61
  "url": "https://jmedchem.example/13",
62
- "abstract": "We designed and synthesized a series of novel small-molecule inhibitors targeting the $\mathrm{P38}$ $\mathrm{MAPK}$ pathway. Compound $\mathrm{JMK}-21$ demonstrated the highest potency ($\mathrm{IC}_{50} = 5\ \mathrm{nM}$) and selectivity in *in vitro* assays. Efficacy shown in a mouse arthritis model. Methods: $\mathrm{IC}_{50}$ assay, $\mathrm{HPLC}$, Animal model.",
63
  "text": "We designed and synthesized a series of novel small-molecule inhibitors targeting the $\mathrm{P38}$ $\mathrm{MAPK}$ pathway. Compound $\mathrm{JMK}-21$ demonstrated the highest potency ($\mathrm{IC}_{50} = 5\ \mathrm{nM}$) and selectivity in *in vitro* assays. Efficacy shown in a mouse arthritis model. Methods: $\mathrm{IC}_{50}$ assay, $\mathrm{HPLC}$, Animal model."
64
  },
65
  {
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- "title": "Cryo-EM Structure of the Human $\mathrm{GABA}_\mathrm{A}$ Receptor Bound to Diazepam",
67
  "authors": ["Sato T", "Gao L"],
68
  "doi": "10.1400/biotech.cryo.17",
69
  "source": "Cell",
70
  "url": "https://cell.example/14",
71
- "abstract": "The high-resolution ($2.5\ \mathrm{\AA}$) cryo-electron microscopy (Cryo-EM) structure of the $\mathrm{GABA}_\mathrm{A}$ receptor was determined in complex with the benzodiazepine, diazepam. The structure reveals the precise binding site and conformational changes induced upon ligand binding. Implications for drug design discussed. Methods: Cryo-EM, Single-particle analysis.",
72
- "text": "The high-resolution ($2.5\ \mathrm{\AA}$) cryo-electron microscopy (Cryo-EM) structure of the $\mathrm{GABA}_\mathrm{A}$ receptor was determined in complex with the benzodiazepine, diazepam. The structure reveals the precise binding site and conformational changes induced upon ligand binding. Implications for drug design discussed. Methods: Cryo-EM, Single-particle analysis."
73
  },
74
  {
75
  "title": "Effectiveness of a Robotic Surgical System for Minimally Invasive Prostatectomy",
@@ -81,12 +81,12 @@
81
  "text": "A retrospective cohort study comparing 500 robotic-assisted vs. 500 open prostatectomy procedures found significantly lower blood loss and shorter hospital stay in the robotic group. No difference in long-term oncological outcomes. Med device implications are clear. Methods: Retrospective Cohort, Propensity Score Matching."
82
  },
83
  {
84
- "title": "CRISPR-Mediated Gene Editing for Correction of the $\mathrm{CFTR}$ Mutation in Primary Airway Cells",
85
  "authors": ["Zhang Q", "Doudna J"],
86
  "doi": "10.1600/biotech.crispr.05",
87
  "source": "Science",
88
  "url": "https://science.example/16",
89
- "abstract": "We used an $\mathrm{AAV}$-delivered $\mathrm{CRISPR}$-$\mathrm{Cas9}$ system to correct the $\Delta\mathrm{F508}$ mutation in cystic fibrosis transmembrane conductance regulator ($\mathrm{CFTR}$) in primary human bronchial epithelial cells. Correction efficiency reached $40\%$ and restored chloride channel function. Methods: $\mathrm{CRISPR/Cas9}$, $\mathrm{AAV}$ delivery, Patch-clamp electrophysiology.",
90
  "text": "We used an $\mathrm{AAV}$-delivered $\mathrm{CRISPR}$-$\mathrm{Cas9}$ system to correct the $\Delta\mathrm{F508}$ mutation in cystic fibrosis transmembrane conductance regulator ($\mathrm{CFTR}$) in primary human bronchial epithelial cells. Correction efficiency reached $40\%$ and restored chloride channel function. Methods: $\mathrm{CRISPR/Cas9}$, $\mathrm{AAV}$ delivery, Patch-clamp electrophysiology."
91
  }
92
  ]
 
50
  "doi": "10.1200/medtech.cgm.20",
51
  "source": "Diabetes Care",
52
  "url": "https://diabetescare.example/12",
53
+ "abstract": "A 12-week prospective study (n=150) assessed the impact of a new minimally invasive continuous glucose monitor (CGM) on HbA1c levels. Mean HbA1c reduction was $0.8\%$, significantly greater than the control group. Patient satisfaction was high. Methods: RCT, HbA1c measurement, Statistical analysis.",
54
  "text": "A 12-week prospective study (n=150) assessed the impact of a new minimally invasive continuous glucose monitor (CGM) on $\mathrm{HbA1c}$ levels. Mean $\mathrm{HbA1c}$ reduction was $0.8\%$, significantly greater than the control group. Patient satisfaction was high. Methods: RCT, $\mathrm{HbA1c}$ measurement, Statistical analysis."
55
  },
56
  {
57
+ "title": "Targeting the P38 MAPK Pathway for Novel Anti-inflammatory Drug Development",
58
  "authors": ["Jones M", "Kumar R"],
59
  "doi": "10.1300/pharma.p38.25",
60
  "source": "Journal of Medicinal Chemistry",
61
  "url": "https://jmedchem.example/13",
62
+ "abstract": "We designed and synthesized a series of novel small-molecule inhibitors targeting the P38 MAPK pathway. Compound JMK-21 demonstrated the highest potency ($\mathrm{IC}_{50} = 5\ \mathrm{nM}$) and selectivity in *in vitro* assays. Efficacy shown in a mouse arthritis model. Methods: $\mathrm{IC}_{50}$ assay, $\mathrm{HPLC}$, Animal model.",
63
  "text": "We designed and synthesized a series of novel small-molecule inhibitors targeting the $\mathrm{P38}$ $\mathrm{MAPK}$ pathway. Compound $\mathrm{JMK}-21$ demonstrated the highest potency ($\mathrm{IC}_{50} = 5\ \mathrm{nM}$) and selectivity in *in vitro* assays. Efficacy shown in a mouse arthritis model. Methods: $\mathrm{IC}_{50}$ assay, $\mathrm{HPLC}$, Animal model."
64
  },
65
  {
66
+ "title": "Cryo-EM Structure of the Human GABAA Receptor Bound to Diazepam",
67
  "authors": ["Sato T", "Gao L"],
68
  "doi": "10.1400/biotech.cryo.17",
69
  "source": "Cell",
70
  "url": "https://cell.example/14",
71
+ "abstract": "The high-resolution ($2.5\ \mathrm{\AA}$) cryo-electron microscopy ($\mathrm{Cryo}$-$\mathrm{EM}$) structure of the $\mathrm{GABA}_{\mathrm{A}}$ receptor was determined in complex with the benzodiazepine, diazepam. The structure reveals the precise binding site and conformational changes induced upon ligand binding. Implications for drug design discussed. Methods: $\mathrm{Cryo}$-$\mathrm{EM}$, Single-particle analysis.",
72
+ "text": "The high-resolution ($2.5\ \mathrm{\AA}$) cryo-electron microscopy ($\mathrm{Cryo}$-$\mathrm{EM}$) structure of the $\mathrm{GABA}_{\mathrm{A}}$ receptor was determined in complex with the benzodiazepine, diazepam. The structure reveals the precise binding site and conformational changes induced upon ligand binding. Implications for drug design discussed. Methods: $\mathrm{Cryo}$-$\mathrm{EM}$, Single-particle analysis."
73
  },
74
  {
75
  "title": "Effectiveness of a Robotic Surgical System for Minimally Invasive Prostatectomy",
 
81
  "text": "A retrospective cohort study comparing 500 robotic-assisted vs. 500 open prostatectomy procedures found significantly lower blood loss and shorter hospital stay in the robotic group. No difference in long-term oncological outcomes. Med device implications are clear. Methods: Retrospective Cohort, Propensity Score Matching."
82
  },
83
  {
84
+ "title": "CRISPR-Mediated Gene Editing for Correction of the CFTR Mutation in Primary Airway Cells",
85
  "authors": ["Zhang Q", "Doudna J"],
86
  "doi": "10.1600/biotech.crispr.05",
87
  "source": "Science",
88
  "url": "https://science.example/16",
89
+ "abstract": "We used an AAV-delivered CRISPR-Cas9 system to correct the $\Delta\mathrm{F508}$ mutation in cystic fibrosis transmembrane conductance regulator ($\mathrm{CFTR}$) in primary human bronchial epithelial cells. Correction efficiency reached $40\%$ and restored chloride channel function. Methods: $\mathrm{CRISPR/Cas9}$, $\mathrm{AAV}$ delivery, Patch-clamp electrophysiology.",
90
  "text": "We used an $\mathrm{AAV}$-delivered $\mathrm{CRISPR}$-$\mathrm{Cas9}$ system to correct the $\Delta\mathrm{F508}$ mutation in cystic fibrosis transmembrane conductance regulator ($\mathrm{CFTR}$) in primary human bronchial epithelial cells. Correction efficiency reached $40\%$ and restored chloride channel function. Methods: $\mathrm{CRISPR/Cas9}$, $\mathrm{AAV}$ delivery, Patch-clamp electrophysiology."
91
  }
92
  ]