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<!DOCTYPE html><html lang="en" class="ibm_plex_sans_b691eaa6-module__i_FSZa__variable jetbrains_mono_32dfc0ee-module__kJDCNG__variable source_serif_4_ae8a7e1e-module__s-G0YW__variable" data-lite="true" data-lite-theme="light"><head><meta charSet="utf-8"/><meta name="viewport" content="width=device-width, initial-scale=1"/><link rel="preload" href="/_next/static/media/03fc1b4a8d284b5e-s.p.09.f.n_ccld80.woff2" as="font" crossorigin="" type="font/woff2"/><link rel="preload" href="/_next/static/media/68d403cf9f2c68c5-s.p.0nhx~dwif.9~q.woff2" as="font" crossorigin="" type="font/woff2"/><link rel="preload" href="/_next/static/media/70bc3e132a0a741e-s.p.1409xf.ylxg8g.woff2" as="font" crossorigin="" type="font/woff2"/><link rel="stylesheet" href="/_next/static/chunks/0mcnwne7fbvrn.css" data-precedence="next"/><link rel="preload" as="script" fetchPriority="low" href="/_next/static/chunks/093v6frwfj2w2.js"/><script src="/_next/static/chunks/0mwkzwyfu_tq7.js" async=""></script><script src="/_next/static/chunks/0w6l7..-v13bf.js" async=""></script><script src="/_next/static/chunks/0xvgbbawvq~-c.js" async=""></script><script src="/_next/static/chunks/turbopack-0on-mbswozq4k.js" async=""></script><script src="/_next/static/chunks/0jtcn4hlq-quv.js" async=""></script><script src="/_next/static/chunks/0b53uqa6spsqk.js" async=""></script><script src="/_next/static/chunks/01t9uk2orgy74.js" async=""></script><script src="/_next/static/chunks/05-84t851vg~r.js" async=""></script><script src="/_next/static/chunks/0885gnxs1valw.js" async=""></script><meta name="next-size-adjust" content=""/><title>Hetionet Lite</title><meta name="description" content="Research dashboard for Hetionet-informed investigations: evidence, validation, and quantum–classical model inspection."/><script src="/_next/static/chunks/03~yq9q893hmn.js" noModule=""></script></head><body><div hidden=""><!--$--><!--/$--></div><!--$--><!--$?--><template id="B:0"></template><aside class="sidebar"><div class="sidebar-header-row"><button type="button" class="sidebar-toggle" title="Collapse sidebar" aria-expanded="true" aria-label="Toggle sidebar"></button></div><div class="brand"><div class="brand-icon" aria-hidden="true"></div><div class="brand-text"><div class="brand-name">Hetionet Lite</div><div class="brand-tagline">Graph-bridged evidence · quantum &amp; classical modeling</div><div class="brand-ver">v0.7.2</div></div></div><div class="section-label">Workflow</div><a class="nav-item" href="/initialize/"><span class="nav-num">01</span><div class="nav-text"><div class="nav-title">Initialize</div><div class="nav-sub">Protocol &amp; cohort definition</div></div></a><a class="nav-item" href="/experiment/"><span class="nav-num">02</span><div class="nav-text"><div class="nav-title">Experiment</div><div class="nav-sub">Evidence generation</div></div></a><a class="nav-item" href="/validate/"><span class="nav-num">03</span><div class="nav-text"><div class="nav-title">Validate</div><div class="nav-sub">Reproducibility &amp; trust</div></div></a><a class="nav-item active" href="/visualize/"><span class="nav-num">04</span><div class="nav-text"><div class="nav-title">Visualize</div><div class="nav-sub">Structures &amp; embeddings</div></div></a><div class="section-label">System</div><a class="nav-item" href="/operations/"><span class="nav-icon"></span><div class="nav-text"><div class="nav-title">Operations</div></div></a><a class="nav-item" href="/settings/"><span class="nav-icon"></span><div class="nav-text"><div class="nav-title">Settings</div></div></a><div style="margin-top:12px"><div class="section-label">Appearance</div><div class="theme-row lite-theme-toggle-row" style="display:flex;gap:4px;padding:4px;border-radius:6px;border:1px solid var(--border);background:var(--paper-alt)" role="group" aria-label="Theme"><button type="button" disabled="" aria-pressed="true" style="flex:1;display:flex;align-items:center;justify-content:center;gap:6px;padding:5px 10px;border:none;border-radius:4px;background:var(--card);color:var(--ink);font-size:11px;font-weight:600;letter-spacing:0.04em;cursor:default;opacity:0.6;font-family:var(--font-sans);transition:background 0.15s, color 0.15s"><span aria-hidden="true" style="font-size:12px"></span>Light</button><button type="button" disabled="" aria-pressed="false" style="flex:1;display:flex;align-items:center;justify-content:center;gap:6px;padding:5px 10px;border:none;border-radius:4px;background:transparent;color:var(--muted);font-size:11px;font-weight:500;letter-spacing:0.04em;cursor:default;opacity:0.6;font-family:var(--font-sans);transition:background 0.15s, color 0.15s"><span aria-hidden="true" style="font-size:12px"></span>Dark</button></div></div><div class="status-bar" style="border-top:1px solid var(--gold, #C8A45A)"><span style="display:inline-block;width:6px;height:6px;border-radius:50%;background:var(--gold, #C8A45A);margin-right:6px" aria-hidden="true"></span><span class="mono" style="color:var(--gold, #C8A45A);font-weight:600">Demo · HF Space</span><div style="color:var(--faint);font-size:10px;margin-top:4px;line-height:1.4">Static build · no backend · mock data only</div></div></aside><div class="sidebar-floating-tooltip" aria-hidden="true"></div><main class="main"><div class="page-hero"><div><div class="step">04 · VISUALIZE</div><h1 class="h1" aria-busy="true">Loading evidence layers…</h1><p class="lede" style="opacity:0.6">Resolving job, evidence matrix, model agreement, and quantum circuit.</p></div><span class="pill">○ loading</span></div><div class="panel" aria-hidden="true"><div style="height:14px;width:55%;background:var(--border-soft);border-radius:4px;margin-bottom:12px"></div><div style="height:10px;width:80%;background:var(--border-soft);border-radius:4px"></div></div></main><!--/$--><!--/$--><script>requestAnimationFrame(function(){$RT=performance.now()});</script><script src="/_next/static/chunks/093v6frwfj2w2.js" id="_R_" async=""></script><div hidden id="S:0"><aside class="sidebar"><div class="sidebar-header-row"><button type="button" class="sidebar-toggle" title="Collapse sidebar" aria-expanded="true" aria-label="Toggle sidebar"></button></div><div class="brand"><div class="brand-icon" aria-hidden="true"></div><div class="brand-text"><div class="brand-name">Hetionet Lite</div><div class="brand-tagline">Graph-bridged evidence · quantum &amp; classical modeling</div><div class="brand-ver">v0.7.2</div></div></div><div class="section-label">Workflow</div><a class="nav-item" href="/initialize/"><span class="nav-num">01</span><div class="nav-text"><div class="nav-title">Initialize</div><div class="nav-sub">Protocol &amp; cohort definition</div></div></a><a class="nav-item" href="/experiment/"><span class="nav-num">02</span><div class="nav-text"><div class="nav-title">Experiment</div><div class="nav-sub">Evidence generation</div></div></a><a class="nav-item" href="/validate/"><span class="nav-num">03</span><div class="nav-text"><div class="nav-title">Validate</div><div class="nav-sub">Reproducibility &amp; trust</div></div></a><a class="nav-item active" href="/visualize/"><span class="nav-num">04</span><div class="nav-text"><div class="nav-title">Visualize</div><div class="nav-sub">Structures &amp; embeddings</div></div></a><div class="section-label">System</div><a class="nav-item" href="/operations/"><span class="nav-icon"></span><div class="nav-text"><div class="nav-title">Operations</div></div></a><a class="nav-item" href="/settings/"><span class="nav-icon"></span><div class="nav-text"><div class="nav-title">Settings</div></div></a><div style="margin-top:12px"><div class="section-label">Appearance</div><div class="theme-row lite-theme-toggle-row" style="display:flex;gap:4px;padding:4px;border-radius:6px;border:1px solid var(--border);background:var(--paper-alt)" role="group" aria-label="Theme"><button type="button" disabled="" aria-pressed="true" style="flex:1;display:flex;align-items:center;justify-content:center;gap:6px;padding:5px 10px;border:none;border-radius:4px;background:var(--card);color:var(--ink);font-size:11px;font-weight:600;letter-spacing:0.04em;cursor:default;opacity:0.6;font-family:var(--font-sans);transition:background 0.15s, color 0.15s"><span aria-hidden="true" style="font-size:12px"></span>Light</button><button type="button" disabled="" aria-pressed="false" style="flex:1;display:flex;align-items:center;justify-content:center;gap:6px;padding:5px 10px;border:none;border-radius:4px;background:transparent;color:var(--muted);font-size:11px;font-weight:500;letter-spacing:0.04em;cursor:default;opacity:0.6;font-family:var(--font-sans);transition:background 0.15s, color 0.15s"><span aria-hidden="true" style="font-size:12px"></span>Dark</button></div></div><div class="status-bar" style="border-top:1px solid var(--gold, #C8A45A)"><span style="display:inline-block;width:6px;height:6px;border-radius:50%;background:var(--gold, #C8A45A);margin-right:6px" aria-hidden="true"></span><span class="mono" style="color:var(--gold, #C8A45A);font-weight:600">Demo · HF Space</span><div style="color:var(--faint);font-size:10px;margin-top:4px;line-height:1.4">Static build · no backend · mock data only</div></div></aside><div class="sidebar-floating-tooltip" aria-hidden="true"></div><main class="main"><div class="page-hero"><div><div class="step">04 · VISUALIZE</div><h1 class="h1">Molecule · Circuit · Path · Evidence</h1><p class="lede">Five focused views — a 2D molecular sketch, the Pauli feature-map quantum circuit, the compound → gene → disease evidence path, the six-layer evidence matrix, and per-family model agreement. All rendered as static SVG so the lite build stays small. The full version replaces these with interactive 3D / live-job-driven counterparts.</p></div><span class="pill" style="background:var(--paper-alt);color:var(--gold)">● demo</span></div><div style="display:grid;grid-template-columns:repeat(auto-fit, minmax(360px, 1fr));gap:16px"><section class="panel"><div class="panel-head"><div><div class="eyebrow">PREVIEW · MOLECULE</div><div class="panel-title" style="color:var(--ink)">Inaxaplin (illustrative)</div></div><span class="pill">DEMO · ChEMBL_INX-1</span></div><p class="panel-purpose" style="margin-bottom:6px">Stylised 2D structural sketch — fused aromatic system + amide side chain + CF₃ group + hydroxyl handle. The full version renders an interactive 3D conformation via WebGL; this lite view is a static SVG that ships zero extra JS.</p><svg viewBox="0 0 320 220" width="100%" height="240" role="img" aria-label="2D structure sketch of Inaxaplin (illustrative)" style="display:block;color:var(--ink)"><g><line x1="60" y1="110" x2="80" y2="96" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="61.491002095344655" y1="112.1300029933495" x2="81.49100209534465" y2="98.1300029933495" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="80" y1="96" x2="100" y2="110" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="78.50899790465535" y1="98.1300029933495" x2="98.50899790465535" y2="112.1300029933495" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="100" y1="110" x2="100" y2="134" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="97.4" y1="110" x2="97.4" y2="134" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="100" y1="134" x2="80" y2="148" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="98.50899790465535" y1="131.8699970066505" x2="78.50899790465535" y2="145.8699970066505" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="80" y1="148" x2="60" y2="134" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="81.49100209534465" y1="145.8699970066505" x2="61.491002095344655" y2="131.8699970066505" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="60" y1="134" x2="60" y2="110" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="62.6" y1="134" x2="62.6" y2="110" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="100" y1="110" x2="120" y2="96" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="101.49100209534465" y1="112.1300029933495" x2="121.49100209534465" y2="98.1300029933495" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="120" y1="96" x2="140" y2="110" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="118.50899790465535" y1="98.1300029933495" x2="138.50899790465536" y2="112.1300029933495" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="140" y1="110" x2="140" y2="134" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="137.4" y1="110" x2="137.4" y2="134" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="140" y1="134" x2="120" y2="148" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="138.50899790465536" y1="131.8699970066505" x2="118.50899790465535" y2="145.8699970066505" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><g><line x1="120" y1="148" x2="100" y2="134" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="121.49100209534465" y1="145.8699970066505" x2="101.49100209534465" y2="131.8699970066505" stroke-width="1.2" style="stroke:var(--ink);opacity:0.5" stroke-dasharray="3 2"></line></g><line x1="80" y1="96" x2="80" y2="72" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="140" y1="110" x2="162" y2="110" stroke-width="1.6" style="stroke:var(--ink)"></line><g><line x1="162" y1="110" x2="180" y2="96" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="163.96460996324774" y1="112.52592709560425" x2="181.96460996324774" y2="98.52592709560425" stroke-width="1.2" style="stroke:var(--ink);opacity:0.85"></line></g><line x1="180" y1="96" x2="200" y2="110" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="200" y1="110" x2="218" y2="96" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="140" y1="134" x2="162" y2="156" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="162" y1="156" x2="174" y2="174" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="162" y1="156" x2="156" y2="178" stroke-width="1.6" style="stroke:var(--ink)"></line><line x1="162" y1="156" x2="144" y2="168" stroke-width="1.6" style="stroke:var(--ink)"></line><g><circle cx="100" cy="110" r="9" style="fill:var(--card);stroke:#3a4d8a" stroke-width="1.6"></circle><text x="100" y="113.8" font-size="11" font-weight="700" text-anchor="middle" style="fill:#3a4d8a">N</text></g><g><circle cx="180" cy="96" r="9" style="fill:var(--card);stroke:#3a4d8a" stroke-width="1.6"></circle><text x="180" y="99.8" font-size="11" font-weight="700" text-anchor="middle" style="fill:#3a4d8a">N</text></g><g><circle cx="218" cy="96" r="9" style="fill:var(--card);stroke:#b04a3a" stroke-width="1.6"></circle><text x="218" y="99.8" font-size="11" font-weight="700" text-anchor="middle" style="fill:#b04a3a">O</text></g><g><circle cx="174" cy="174" r="9" style="fill:var(--card);stroke:#6b7d5f" stroke-width="1.6"></circle><text x="174" y="177.8" font-size="11" font-weight="700" text-anchor="middle" style="fill:#6b7d5f">F</text></g><g><circle cx="156" cy="178" r="9" style="fill:var(--card);stroke:#6b7d5f" stroke-width="1.6"></circle><text x="156" y="181.8" font-size="11" font-weight="700" text-anchor="middle" style="fill:#6b7d5f">F</text></g><g><circle cx="144" cy="168" r="9" style="fill:var(--card);stroke:#6b7d5f" stroke-width="1.6"></circle><text x="144" y="171.8" font-size="11" font-weight="700" text-anchor="middle" style="fill:#6b7d5f">F</text></g><g><circle cx="80" cy="72" r="9" style="fill:var(--card);stroke:#3a4d8a" stroke-width="1.6"></circle><text x="80" y="75.8" font-size="11" font-weight="700" text-anchor="middle" style="fill:#3a4d8a">N</text></g><text x="162" y="195" font-size="10" font-weight="600" text-anchor="middle" style="fill:var(--muted)">CF₃</text><text x="80" y="62" font-size="10" font-weight="600" text-anchor="middle" style="fill:var(--muted)">NH</text></svg><div style="display:flex;flex-wrap:wrap;gap:14px;margin-top:8px;font-size:11px;color:var(--muted)"><span><strong style="color:var(--ink);font-weight:600">MW</strong> <!-- -->410.4</span><span><strong style="color:var(--ink);font-weight:600">logP</strong> <!-- -->2.7</span><span><strong style="color:var(--ink);font-weight:600">HBD/HBA</strong> <!-- -->1 / 6</span><span><strong style="color:var(--ink);font-weight:600">TPSA</strong> <!-- -->84.3</span><span><strong style="color:var(--ink);font-weight:600">Lipinski</strong> <!-- -->✓ pass</span></div></section><section class="panel"><div class="panel-head"><div><div class="eyebrow">PREVIEW · QUANTUM CIRCUIT</div><div class="panel-title" style="color:var(--ink)">Pauli feature map (reps=<!-- -->2<!-- -->)</div></div><span class="pill">4<!-- --> qubits · <!-- -->16384<!-- --> shots</span></div><p class="panel-purpose" style="margin-bottom:6px">The headline encoding circuit. Hadamards prepare uniform superposition, single-qubit RZ rotations encode one data feature each, then pairwise CNOTs entangle adjacent qubits and a second RZ layer encodes pair-wise feature products. Two repetitions deepen the Hilbert-space embedding before measurement.</p><svg viewBox="0 0 430 196" width="100%" height="200" role="img" aria-label="Pauli feature map quantum circuit, 4 qubits, reps=2" style="display:block"><g><line x1="52" y1="28" x2="418" y2="28" stroke-width="1" style="stroke:var(--border)"></line><text x="46" y="32" font-size="11" font-weight="600" text-anchor="end" style="fill:var(--muted);font-family:var(--font-mono), monospace">q<!-- -->0</text></g><g><line x1="52" y1="64" x2="418" y2="64" stroke-width="1" style="stroke:var(--border)"></line><text x="46" y="68" font-size="11" font-weight="600" text-anchor="end" style="fill:var(--muted);font-family:var(--font-mono), monospace">q<!-- -->1</text></g><g><line x1="52" y1="100" x2="418" y2="100" stroke-width="1" style="stroke:var(--border)"></line><text x="46" y="104" font-size="11" font-weight="600" text-anchor="end" style="fill:var(--muted);font-family:var(--font-mono), monospace">q<!-- -->2</text></g><g><line x1="52" y1="136" x2="418" y2="136" stroke-width="1" style="stroke:var(--border)"></line><text x="46" y="140" font-size="11" font-weight="600" text-anchor="end" style="fill:var(--muted);font-family:var(--font-mono), monospace">q<!-- -->3</text></g><g><rect x="70" y="17" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--gold)" stroke-width="1.4"></rect><text x="83" y="31.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--gold);font-family:var(--font-mono), monospace">H</text></g><g><rect x="70" y="53" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--gold)" stroke-width="1.4"></rect><text x="83" y="67.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--gold);font-family:var(--font-mono), monospace">H</text></g><g><rect x="70" y="89" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--gold)" stroke-width="1.4"></rect><text x="83" y="103.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--gold);font-family:var(--font-mono), monospace">H</text></g><g><rect x="70" y="125" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--gold)" stroke-width="1.4"></rect><text x="83" y="139.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--gold);font-family:var(--font-mono), monospace">H</text></g><g><rect x="108" y="17" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--purple)" stroke-width="1.4"></rect><text x="121" y="31.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--purple);font-family:var(--font-mono), monospace">RZ</text><text x="121" y="50" font-size="9" text-anchor="middle" style="fill:var(--muted);font-family:var(--font-mono), monospace">φ(x₀)</text></g><g><rect x="108" y="53" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--purple)" stroke-width="1.4"></rect><text x="121" y="67.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--purple);font-family:var(--font-mono), monospace">RZ</text><text x="121" y="86" font-size="9" text-anchor="middle" style="fill:var(--muted);font-family:var(--font-mono), monospace">φ(x₁)</text></g><g><rect x="108" y="89" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--purple)" stroke-width="1.4"></rect><text x="121" y="103.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--purple);font-family:var(--font-mono), monospace">RZ</text><text x="121" y="122" font-size="9" text-anchor="middle" style="fill:var(--muted);font-family:var(--font-mono), monospace">φ(x₂)</text></g><g><rect x="108" y="125" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--purple)" stroke-width="1.4"></rect><text x="121" y="139.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--purple);font-family:var(--font-mono), monospace">RZ</text><text x="121" y="158" font-size="9" text-anchor="middle" style="fill:var(--muted);font-family:var(--font-mono), monospace">φ(x₃)</text></g><g><line x1="159" y1="28" x2="159" y2="64" stroke-width="1.4" style="stroke:var(--ink)"></line><circle cx="159" cy="28" r="4" style="fill:var(--ink)"></circle><circle cx="159" cy="64" r="9" style="fill:var(--card);stroke:var(--ink)" stroke-width="1.4"></circle><line x1="152" y1="64" x2="166" y2="64" stroke-width="1.2" style="stroke:var(--ink)"></line><line x1="159" y1="57" x2="159" y2="71" stroke-width="1.2" style="stroke:var(--ink)"></line></g><g><line x1="197" y1="64" x2="197" y2="100" stroke-width="1.4" style="stroke:var(--ink)"></line><circle cx="197" cy="64" r="4" style="fill:var(--ink)"></circle><circle cx="197" cy="100" r="9" style="fill:var(--card);stroke:var(--ink)" stroke-width="1.4"></circle><line x1="190" y1="100" x2="204" y2="100" stroke-width="1.2" style="stroke:var(--ink)"></line><line x1="197" y1="93" x2="197" y2="107" stroke-width="1.2" style="stroke:var(--ink)"></line></g><g><line x1="235" y1="100" x2="235" y2="136" stroke-width="1.4" style="stroke:var(--ink)"></line><circle cx="235" cy="100" r="4" style="fill:var(--ink)"></circle><circle cx="235" cy="136" r="9" style="fill:var(--card);stroke:var(--ink)" stroke-width="1.4"></circle><line x1="228" y1="136" x2="242" y2="136" stroke-width="1.2" style="stroke:var(--ink)"></line><line x1="235" y1="129" x2="235" y2="143" stroke-width="1.2" style="stroke:var(--ink)"></line></g><g><rect x="260" y="17" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--purple)" stroke-width="1.4"></rect><text x="273" y="31.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--purple);font-family:var(--font-mono), monospace">RZ</text><text x="273" y="50" font-size="9" text-anchor="middle" style="fill:var(--muted);font-family:var(--font-mono), monospace">φ(x₀,x₁)</text></g><g><rect x="260" y="89" width="26" height="22" rx="3" ry="3" style="fill:var(--card);stroke:var(--purple)" stroke-width="1.4"></rect><text x="273" y="103.6" font-size="10.5" font-weight="700" text-anchor="middle" style="fill:var(--purple);font-family:var(--font-mono), monospace">RZ</text><text x="273" y="122" font-size="9" text-anchor="middle" style="fill:var(--muted);font-family:var(--font-mono), monospace">φ(x₂,x₃)</text></g><g><line x1="311" y1="28" x2="311" y2="64" stroke-width="1.4" style="stroke:var(--ink)"></line><circle cx="311" cy="28" r="4" style="fill:var(--ink)"></circle><circle cx="311" cy="64" r="9" style="fill:var(--card);stroke:var(--ink)" stroke-width="1.4"></circle><line x1="304" y1="64" x2="318" y2="64" stroke-width="1.2" style="stroke:var(--ink)"></line><line x1="311" y1="57" x2="311" y2="71" stroke-width="1.2" style="stroke:var(--ink)"></line></g><g><line x1="349" y1="100" x2="349" y2="136" stroke-width="1.4" style="stroke:var(--ink)"></line><circle cx="349" cy="100" r="4" style="fill:var(--ink)"></circle><circle cx="349" cy="136" r="9" style="fill:var(--card);stroke:var(--ink)" stroke-width="1.4"></circle><line x1="342" y1="136" x2="356" y2="136" stroke-width="1.2" style="stroke:var(--ink)"></line><line x1="349" y1="129" x2="349" y2="143" stroke-width="1.2" style="stroke:var(--ink)"></line></g><line x1="387" y1="20" x2="387" y2="144" stroke-width="1" stroke-dasharray="3 3" style="stroke:var(--faint);opacity:0.7"></line><text x="401" y="100" font-size="10" font-weight="700" text-anchor="start" style="fill:var(--gold);font-family:var(--font-mono), monospace">× <!-- -->2<!-- --> reps</text></svg><div style="display:flex;flex-wrap:wrap;gap:14px;margin-top:4px;font-size:11px;color:var(--muted)"><span><strong style="color:var(--ink);font-weight:600">backend</strong> <!-- -->ibm_torino · cuStateVec sim</span><span><strong style="color:var(--ink);font-weight:600">depth</strong> <!-- -->10</span><span><strong style="color:var(--ink);font-weight:600">entangler</strong> <!-- -->linear chain</span><span><strong style="color:var(--ink);font-weight:600">ZNE</strong> <!-- -->1× / 3× / 5× (Pauli Path)</span></div></section></div><section class="panel"><div class="panel-head"><div><div class="eyebrow">TOOL · PATH DIAGRAM</div><div class="panel-title">How the model reaches the candidate</div></div><span class="pill" style="background:var(--green-bg);color:var(--green)">● path clears threshold</span></div><p class="panel-purpose">A walk through Hetionet — compound, target, pathway, disease — with weights from the trained model. The path must aggregate to at least the threshold (<!-- -->0.55<!-- -->) to count as mechanistic support.</p><div style="display:flex;align-items:stretch;gap:6px;flex-wrap:wrap;padding:12px 0 8px;overflow-x:auto"><div style="display:flex;align-items:center;gap:6px;flex:0 0 auto"><div title="Inaxaplin" style="padding:10px 14px;min-width:110px;max-width:180px;background:var(--card);border:1px solid var(--teal);border-radius:6px;text-align:center;box-shadow:0 0 14px rgba(107,181,181,0.18)" data-kind="entity"><div style="font-size:9.5px;color:var(--faint);letter-spacing:0.08em;text-transform:uppercase">node</div><div style="font-size:12.5px;font-weight:600;color:var(--ink);overflow:hidden;text-overflow:ellipsis;white-space:nowrap">Inaxaplin</div></div><div style="display:flex;flex-direction:column;align-items:center;min-width:80px;gap:2px" title="Sources: DrugBank, ChEMBL"><div style="font-family:var(--font-mono), monospace;font-size:10.5px;color:var(--gold);letter-spacing:0.04em">CbG</div><div style="width:64px;height:2px;background:var(--gold);border-radius:2px;position:relative"><span style="position:absolute;right:-6px;top:-4px;font-size:10px;color:var(--gold)"></span></div><div style="font-size:10px;color:var(--muted);font-family:var(--font-mono), monospace">w=<!-- -->0.91</div></div><div title="APOL1" style="padding:10px 14px;min-width:110px;max-width:180px;background:var(--card);border:1px solid var(--teal);border-radius:6px;text-align:center;box-shadow:0 0 14px rgba(107,181,181,0.18)" data-kind="entity"><div style="font-size:9.5px;color:var(--faint);letter-spacing:0.08em;text-transform:uppercase">node</div><div style="font-size:12.5px;font-weight:600;color:var(--ink);overflow:hidden;text-overflow:ellipsis;white-space:nowrap">APOL1</div></div></div><div style="display:flex;align-items:center;gap:6px;flex:0 0 auto"><div style="display:flex;flex-direction:column;align-items:center;min-width:80px;gap:2px" title="Sources: Reactome"><div style="font-family:var(--font-mono), monospace;font-size:10.5px;color:var(--gold);letter-spacing:0.04em">GpPW</div><div style="width:64px;height:2px;background:var(--gold);border-radius:2px;position:relative"><span style="position:absolute;right:-6px;top:-4px;font-size:10px;color:var(--gold)"></span></div><div style="font-size:10px;color:var(--muted);font-family:var(--font-mono), monospace">w=<!-- -->0.74</div></div><div title="Lipid metabolism" style="padding:10px 14px;min-width:110px;max-width:180px;background:var(--card);border:1px solid var(--teal);border-radius:6px;text-align:center;box-shadow:0 0 14px rgba(107,181,181,0.18)" data-kind="entity"><div style="font-size:9.5px;color:var(--faint);letter-spacing:0.08em;text-transform:uppercase">node</div><div style="font-size:12.5px;font-weight:600;color:var(--ink);overflow:hidden;text-overflow:ellipsis;white-space:nowrap">Lipid metabolism</div></div></div><div style="display:flex;align-items:center;gap:6px;flex:0 0 auto"><div style="display:flex;flex-direction:column;align-items:center;min-width:80px;gap:2px" title="Sources: DisGeNET, OpenTargets"><div style="font-family:var(--font-mono), monospace;font-size:10.5px;color:var(--gold);letter-spacing:0.04em">PWaD</div><div style="width:64px;height:2px;background:var(--gold);border-radius:2px;position:relative"><span style="position:absolute;right:-6px;top:-4px;font-size:10px;color:var(--gold)"></span></div><div style="font-size:10px;color:var(--muted);font-family:var(--font-mono), monospace">w=<!-- -->0.78</div></div><div title="APOL1-mediated kidney disease" style="padding:10px 14px;min-width:110px;max-width:180px;background:var(--card);border:1px solid var(--teal);border-radius:6px;text-align:center;box-shadow:0 0 14px rgba(107,181,181,0.18)" data-kind="entity"><div style="font-size:9.5px;color:var(--faint);letter-spacing:0.08em;text-transform:uppercase">node</div><div style="font-size:12.5px;font-weight:600;color:var(--ink);overflow:hidden;text-overflow:ellipsis;white-space:nowrap">APOL1-mediated kidney disease</div></div></div></div><div style="display:flex;align-items:center;justify-content:space-between;margin-top:10px;padding:10px 12px;background:var(--paper-alt);border:1px solid var(--border-soft);border-radius:4px"><div style="font-size:12px;color:var(--muted)"><span style="font-weight:600;color:var(--ink)">3<!-- -->-hop path</span> <!-- -->· plausibility <!-- -->0.810<!-- --> vs threshold<!-- --> <!-- -->0.550</div><div style="min-width:140px;height:8px;background:var(--border-soft);border-radius:4px;overflow:hidden" aria-label="147% of threshold"><div style="width:100%;height:100%;background:var(--green)"></div></div></div><div class="panel-footer" style="margin-top:14px"><span>hetionet-v1.0/edges.tsv · path-aggregated weights</span><span><em>supports the candidate</em></span></div></section><section class="panel"><div class="panel-head"><div><div class="eyebrow">TOOL · EVIDENCE STRENGTH MATRIX</div><div class="panel-title">Six layers, who&#x27;s vouching</div></div><span class="badge">Cross-source</span></div><p class="panel-purpose">Each row is an evidence layer; each cell is a finding from that layer with a state — <strong>live</strong> (real source returned data),<!-- --> <strong>supports</strong> / <strong>weakens</strong> (the score moves the right way), <strong>fallback</strong> (synthetic stand-in), or<!-- --> <strong>missing</strong> (no signal at all).</p><div style="display:grid;grid-template-columns:minmax(160px, 200px) 1fr;row-gap:8px;column-gap:14px;align-items:start;margin-top:4px"><div style="display:contents" data-layer="molecule"><div style="padding-top:6px;border-right:1px solid var(--border-soft)"><div style="font-weight:600;font-size:13px">Molecule</div><div style="color:var(--faint);font-size:11px">structure · ADMET</div></div><div style="display:flex;flex-wrap:wrap;gap:8px;padding-bottom:8px;border-bottom:1px solid var(--border-soft)"><span title="Small-molecule inhibitor profile + ADMET in a known-tolerable window." style="display:inline-flex;align-items:center;gap:6px;padding:4px 9px 4px 8px;background:var(--green-bg);border:1px solid var(--green);border-radius:4px;font-size:11.5px;color:var(--ink);max-width:360px"><span style="color:var(--green);font-size:12px"></span><span style="font-weight:600;color:var(--green);text-transform:uppercase;font-size:10px;letter-spacing:0.06em">supports</span><span style="color:var(--muted);font-size:11px;overflow:hidden;text-overflow:ellipsis;white-space:nowrap;max-width:260px">Small-molecule inhibitor profile + ADMET in a known-tolerable window.</span></span></div></div><div style="display:contents" data-layer="kg"><div style="padding-top:6px;border-right:1px solid var(--border-soft)"><div style="font-weight:600;font-size:13px">Knowledge graph</div><div style="color:var(--faint);font-size:11px">Hetionet edges</div></div><div style="display:flex;flex-wrap:wrap;gap:8px;padding-bottom:8px;border-bottom:1px solid var(--border-soft)"><span title="Two-hop CbG → GpPW → PWaD chain backed by multiple curated sources." style="display:inline-flex;align-items:center;gap:6px;padding:4px 9px 4px 8px;background:var(--green-bg);border:1px solid var(--green);border-radius:4px;font-size:11.5px;color:var(--ink);max-width:360px"><span style="color:var(--green);font-size:12px"></span><span style="font-weight:600;color:var(--green);text-transform:uppercase;font-size:10px;letter-spacing:0.06em">supports</span><span style="color:var(--muted);font-size:11px;overflow:hidden;text-overflow:ellipsis;white-space:nowrap;max-width:260px">Two-hop CbG → GpPW → PWaD chain backed by multiple curated sources.</span></span></div></div><div style="display:contents" data-layer="mechanism"><div style="padding-top:6px;border-right:1px solid var(--border-soft)"><div style="font-weight:600;font-size:13px">Mechanism</div><div style="color:var(--faint);font-size:11px">pathway · target</div></div><div style="display:flex;flex-wrap:wrap;gap:8px;padding-bottom:8px;border-bottom:1px solid var(--border-soft)"><span title="APOL1 → kidney disease pathway implicated in trial readouts." style="display:inline-flex;align-items:center;gap:6px;padding:4px 9px 4px 8px;background:var(--green-bg);border:1px solid var(--green);border-radius:4px;font-size:11.5px;color:var(--ink);max-width:360px"><span style="color:var(--green);font-size:12px"></span><span style="font-weight:600;color:var(--green);text-transform:uppercase;font-size:10px;letter-spacing:0.06em">supports</span><span style="color:var(--muted);font-size:11px;overflow:hidden;text-overflow:ellipsis;white-space:nowrap;max-width:260px">APOL1 → kidney disease pathway implicated in trial readouts.</span></span></div></div><div style="display:contents" data-layer="clinical"><div style="padding-top:6px;border-right:1px solid var(--border-soft)"><div style="font-weight:600;font-size:13px">Clinical</div><div style="color:var(--faint);font-size:11px">trials · outcomes</div></div><div style="display:flex;flex-wrap:wrap;gap:8px;padding-bottom:8px;border-bottom:1px solid var(--border-soft)"><span title="Phase 2/3 readouts on AMKD endpoints — directional consistency only in the demo." style="display:inline-flex;align-items:center;gap:6px;padding:4px 9px 4px 8px;background:var(--green-bg);border:1px solid var(--green);border-radius:4px;font-size:11.5px;color:var(--ink);max-width:360px"><span style="color:var(--green);font-size:12px"></span><span style="font-weight:600;color:var(--green);text-transform:uppercase;font-size:10px;letter-spacing:0.06em">live</span><span style="color:var(--muted);font-size:11px;overflow:hidden;text-overflow:ellipsis;white-space:nowrap;max-width:260px">Phase 2/3 readouts on AMKD endpoints — directional consistency only in the demo.</span></span></div></div><div style="display:contents" data-layer="classical"><div style="padding-top:6px;border-right:1px solid var(--border-soft)"><div style="font-weight:600;font-size:13px">Classical model</div><div style="color:var(--faint);font-size:11px">GBM · LR · MLP</div></div><div style="display:flex;flex-wrap:wrap;gap:8px;padding-bottom:8px;border-bottom:1px solid var(--border-soft)"><span title="RandomForest + ExtraTrees baseline both rank the pair in the top decile." style="display:inline-flex;align-items:center;gap:6px;padding:4px 9px 4px 8px;background:var(--green-bg);border:1px solid var(--green);border-radius:4px;font-size:11.5px;color:var(--ink);max-width:360px"><span style="color:var(--green);font-size:12px"></span><span style="font-weight:600;color:var(--green);text-transform:uppercase;font-size:10px;letter-spacing:0.06em">supports</span><span style="color:var(--muted);font-size:11px;overflow:hidden;text-overflow:ellipsis;white-space:nowrap;max-width:260px">RandomForest + ExtraTrees baseline both rank the pair in the top decile.</span></span></div></div><div style="display:contents" data-layer="quantum"><div style="padding-top:6px;border-right:1px solid var(--border-soft)"><div style="font-weight:600;font-size:13px">Quantum model</div><div style="color:var(--faint);font-size:11px">kernel · VQC</div></div><div style="display:flex;flex-wrap:wrap;gap:8px;padding-bottom:8px;border-bottom:1px solid var(--border-soft)"><span title="Simulator score (no IBM hardware in this lite demo). Headline run reports the QSVC + Stacking PR-AUC." style="display:inline-flex;align-items:center;gap:6px;padding:4px 9px 4px 8px;background:var(--amber-bg);border:1px solid var(--amber);border-radius:4px;font-size:11.5px;color:var(--ink);max-width:360px"><span style="color:var(--amber);font-size:12px"></span><span style="font-weight:600;color:var(--amber);text-transform:uppercase;font-size:10px;letter-spacing:0.06em">fallback</span><span style="color:var(--muted);font-size:11px;overflow:hidden;text-overflow:ellipsis;white-space:nowrap;max-width:260px">Simulator score (no IBM hardware in this lite demo). Headline run reports the QSVC + Stacking PR-AUC.</span></span></div></div></div><div class="panel-footer" style="margin-top:14px"><span>6<!-- --> cells across 6 layers</span><span><em>Five of six layers support the candidate; the quantum layer is showing the simulator fallback in this demo build.</em></span></div></section><section class="panel"><div class="panel-head"><div><div class="eyebrow">TOOL · MODEL AGREEMENT</div><div class="panel-title">Do families converge?</div></div><span class="pill" style="background:var(--amber-bg);color:var(--amber);border-color:var(--amber);border:1px solid var(--amber)">partial divergence</span></div><p class="panel-purpose">Top score per family vs the cross-family mean. Spread is the signal: small spread means classical/hybrid/quantum agree, large spread means you should probably not bet the run on a single family.</p><div style="display:flex;flex-direction:column;gap:10px;margin-top:6px"><div><div style="display:flex;align-items:baseline;justify-content:space-between;margin-bottom:4px"><div style="font-size:12px;font-weight:600;color:var(--ink);text-transform:capitalize">classical</div><div style="font-size:11px;font-family:var(--font-mono), monospace;color:var(--muted)">0.784<!-- --> <span style="color:var(--muted)">(<!-- -->+<!-- -->0.000<!-- -->)</span></div></div><div style="height:10px;background:var(--border-soft);border-radius:4px;overflow:hidden;position:relative" role="meter" aria-valuemin="0" aria-valuemax="1" aria-valuenow="0.7838"><div style="width:78.38000000000001%;height:100%;background:var(--gold);box-shadow:0 0 10px var(--gold)55"></div><div style="position:absolute;top:-2px;bottom:-2px;left:76.8%;width:1.5px;background:var(--ink);opacity:0.6" aria-hidden="true"></div></div></div><div><div style="display:flex;align-items:baseline;justify-content:space-between;margin-bottom:4px"><div style="font-size:12px;font-weight:600;color:var(--ink);text-transform:capitalize">hybrid</div><div style="font-size:11px;font-family:var(--font-mono), monospace;color:var(--muted)">0.799<!-- --> <span style="color:var(--green)">(<!-- -->+<!-- -->0.015<!-- -->)</span></div></div><div style="height:10px;background:var(--border-soft);border-radius:4px;overflow:hidden;position:relative" role="meter" aria-valuemin="0" aria-valuemax="1" aria-valuenow="0.7987"><div style="width:79.86999999999999%;height:100%;background:var(--teal);box-shadow:0 0 10px var(--teal)55"></div><div style="position:absolute;top:-2px;bottom:-2px;left:76.8%;width:1.5px;background:var(--ink);opacity:0.6" aria-hidden="true"></div></div></div><div><div style="display:flex;align-items:baseline;justify-content:space-between;margin-bottom:4px"><div style="font-size:12px;font-weight:600;color:var(--ink);text-transform:capitalize">quantum</div><div style="font-size:11px;font-family:var(--font-mono), monospace;color:var(--muted)">0.722<!-- --> <span style="color:var(--sienna)">(<!-- -->-0.062<!-- -->)</span></div></div><div style="height:10px;background:var(--border-soft);border-radius:4px;overflow:hidden;position:relative" role="meter" aria-valuemin="0" aria-valuemax="1" aria-valuenow="0.7216"><div style="width:72.16%;height:100%;background:var(--purple);box-shadow:0 0 10px var(--purple)55"></div><div style="position:absolute;top:-2px;bottom:-2px;left:76.8%;width:1.5px;background:var(--ink);opacity:0.6" aria-hidden="true"></div></div></div></div><div style="display:grid;grid-template-columns:repeat(2, 1fr);gap:10px;margin-top:16px"><div style="padding:8px 10px;background:var(--paper-alt);border:1px solid var(--border-soft);border-radius:4px"><div style="font-size:10px;color:var(--faint);text-transform:uppercase;letter-spacing:0.06em">mean</div><div style="font-size:14px;font-weight:600;color:var(--ink);margin-top:2px;font-family:var(--font-mono), monospace">0.768</div></div><div style="padding:8px 10px;background:var(--paper-alt);border:1px solid var(--border-soft);border-radius:4px"><div style="font-size:10px;color:var(--faint);text-transform:uppercase;letter-spacing:0.06em">spread (max−min)</div><div style="font-size:14px;font-weight:600;color:var(--ink);margin-top:2px;font-family:var(--font-mono), monospace">0.077</div></div></div><div style="margin-top:12px;padding:10px 12px;background:var(--amber-bg);border:1px solid var(--amber);border-radius:4px;font-size:12px;color:var(--amber);font-weight:500">Partial divergence — one family disagrees materially. 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