# Multi-stage build for smaller image FROM python:3.10-slim-bookworm AS builder WORKDIR /app # Install build dependencies for Python wheels and ViennaRNA RUN apt-get update && apt-get install -y --no-install-recommends \ build-essential \ wget \ && rm -rf /var/lib/apt/lists/* # Build ViennaRNA from source ARG VIENNARNA_VERSION=2.6.4 RUN wget -q https://www.tbi.univie.ac.at/RNA/download/sourcecode/2_6_x/ViennaRNA-${VIENNARNA_VERSION}.tar.gz \ && tar -xzf ViennaRNA-${VIENNARNA_VERSION}.tar.gz \ && cd ViennaRNA-${VIENNARNA_VERSION} \ && ./configure --without-perl --without-python --without-doc --prefix=/opt/viennarna \ && make -j$(nproc) \ && make install \ && cd .. \ && rm -rf ViennaRNA-${VIENNARNA_VERSION} ViennaRNA-${VIENNARNA_VERSION}.tar.gz # Install Python dependencies to a virtual env for cleaner copy RUN python -m venv /opt/venv ENV PATH="/opt/venv/bin:$PATH" COPY webapp/requirements.txt . RUN pip install --no-cache-dir -r requirements.txt # Production image FROM python:3.10-slim-bookworm WORKDIR /app # Install runtime dependencies for matplotlib and ViennaRNA (libgomp for OpenMP) RUN apt-get update && apt-get install -y --no-install-recommends \ libfreetype6 \ libjpeg62-turbo \ libpng16-16 \ libxcb1 \ libgomp1 \ && rm -rf /var/lib/apt/lists/* # Copy ViennaRNA binaries from builder COPY --from=builder /opt/viennarna /opt/viennarna ENV PATH="/opt/viennarna/bin:${PATH}" # Copy Python virtual environment from builder COPY --from=builder /opt/venv /opt/venv ENV PATH="/opt/venv/bin:$PATH" # Copy application code COPY webapp/ ./webapp/ COPY figures/ ./figures/ COPY output/ ./output/ COPY data/ ./data/ # Create non-root user (HF Spaces requires user with uid 1000) RUN useradd -m -u 1000 user && chown -R user:user /app USER user # Expose port (HF Spaces requires 7860) EXPOSE 7860 # Health check HEALTHCHECK --interval=30s --timeout=10s --start-period=5s --retries=3 \ CMD python -c "import httpx; httpx.get('http://localhost:7860/api/health')" || exit 1 # Run with Uvicorn on port 7860 for HF Spaces CMD ["python", "-m", "uvicorn", "webapp.app.main:app", "--host", "0.0.0.0", "--port", "7860"]